0001171843-19-006387.txt : 20191007 0001171843-19-006387.hdr.sgml : 20191007 20191007125615 ACCESSION NUMBER: 0001171843-19-006387 CONFORMED SUBMISSION TYPE: 10-Q PUBLIC DOCUMENT COUNT: 84 CONFORMED PERIOD OF REPORT: 20190331 FILED AS OF DATE: 20191007 DATE AS OF CHANGE: 20191007 FILER: COMPANY DATA: COMPANY CONFORMED NAME: AMYRIS, INC. CENTRAL INDEX KEY: 0001365916 STANDARD INDUSTRIAL CLASSIFICATION: INDUSTRIAL ORGANIC CHEMICALS [2860] IRS NUMBER: 550856151 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 10-Q SEC ACT: 1934 Act SEC FILE NUMBER: 001-34885 FILM NUMBER: 191140405 BUSINESS ADDRESS: STREET 1: 5885 HOLLIS STREET, SUITE 100 CITY: EMERYVILLE STATE: CA ZIP: 94608 BUSINESS PHONE: 510-450-0761 MAIL ADDRESS: STREET 1: 5885 HOLLIS STREET, SUITE 100 CITY: EMERYVILLE STATE: CA ZIP: 94608 FORMER COMPANY: FORMER CONFORMED NAME: AMYRIS BIOTECHNOLOGIES INC DATE OF NAME CHANGE: 20060613 10-Q 1 f10q_100319p.htm FORM 10-Q

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-Q

(Mark One)

 

x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

 

For the quarterly period ended March 31, 2019

OR

 

o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

 

For the Transition Period from              to

Commission File Number: 001-34885

AMYRIS, INC.

(Exact name of registrant as specified in its charter)

 

Delaware   55-0856151

(State or other jurisdiction of

incorporation or organization)

 

 

(I.R.S. Employer

Identification No.)

 

Amyris, Inc.

5885 Hollis Street, Suite 100

Emeryville, CA 94608

(510) 450-0761

(Address and telephone number of principal executive offices)

 

Securities registered pursuant to Section 12(b) of the Act:

 

Title of each class Trading Symbol(s) Name of each exchange on which registered
Common Stock, $0.0001 par value per share AMRS The Nasdaq Stock Market, LLC

 

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.    Yes  o    No  x

 

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).    Yes  o    No  x

 

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and "emerging growth company" in Rule 12b-2 of the Exchange Act.

 

Large accelerated filer o Accelerated filer x
Non-accelerated filer o Smaller reporting company x
Emerging growth company o    

 

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. o

 

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).    Yes  o    No  x

 

Shares outstanding of the Registrant's common stock:

 

Class Outstanding as of September 26, 2019
Common Stock, $0.0001 par value per share 103,400,207

 

EXPLANATORY NOTE

 

As described in additional detail in the Explanatory Note to our Annual Report on Form 10-K filed on October 1, 2019 for the fiscal year ended December 31, 2018 (the 2018 Form 10-K), on April 5, 2019 and May 14, 2019, the Audit Committee (the Audit Committee) of the Board of Directors of the Company (the Board) and the Board, respectively, determined that the Company would restate its interim condensed consolidated financial statements for the quarterly and year-to-date periods ended March 31, 2018, June 30, 2018 and September 30, 2018 (collectively, the 2018 Non-Reliance Periods). The Company also disclosed that investors should no longer rely upon (i) the Company’s previously released condensed consolidated financial statements for the 2018 Non-Reliance Periods, (ii) earnings releases for the 2018 Non-Reliance Periods and (iv) other communications relating to the Company’s previously released condensed consolidated financial statements for the 2018 Non-Reliance Periods. The restated financial statements for such periods are included in Part II, Item 8 of the 2018 Form 10-K/A filed on October 4, 2019.

 

This Quarterly Report on Form 10-Q for the three months ended March 31, 2019 reflects the comparative restated quarterly financial data for the three months ended March 31, 2018 contained in the 2018 Form 10-K/A filed on October 4, 2019.

 

Due to the restatement of our historical financial statements, we were unable to file the 2018 Form 10-K and 10-K/A until October 1, 2019 and October 4, 2019, respectively. We were unable to file this Quarterly Report on Form 10-Q until the 2018 Form 10-K was filed, which was after the prescribed May 10, 2019 due date and the five day extension period provided by Rule 12b-25 promulgated under the Securities Exchange Act of 1934.

 

 

 

 

 

 

AMYRIS, INC.

TABLE OF CONTENTS

 

 

    Page
  PART I  
Item 1. Financial Statements (unaudited) 5
  Condensed Consolidated Balance Sheets as of March 31, 2019 and December 31, 2018 5
  Condensed Consolidated Statements of Operations for the Three Months Ended March 31, 2019 and 2018 6
  Condensed Consolidated Statements of Comprehensive Loss for the Three Months Ended March 31, 2019 and 2018 7
  Condensed Consolidated Statements of Stockholders' Deficit and Mezzanine Equity for the Three Months Ended March 31, 2019 and 2018 8
  Condensed Consolidated Statements of Cash Flows for the Three Months Ended March 31, 2019 and 2018 9
  Notes to Condensed Consolidated Financial Statements 11
Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations 35
Item 4. Controls and Procedures 43
     
  PART II  
Item 1. Legal Proceedings 44
Item 1A. Risk Factors 44
Item 2. Unregistered Sales of Equity Securities and Use of Proceeds 44
Item 3. Defaults Upon Senior Securities 44
Item 5. Other Information 44
Item 6. Exhibits 44
SIGNATURES    

 

 

4

 

PART I

ITEM 1. FINANCIAL STATEMENTS

AMYRIS, INC.

CONDENSED CONSOLIDATED BALANCE SHEETS

(Unaudited)

 

(In thousands, except shares and per share amounts)  March 31,
2019
  December 31,
2018
Assets          
Current assets:          
Cash and cash equivalents  $5,153   $45,353 
Restricted cash   623    741 
Accounts receivable, net of allowance of $126 and $642, respectively   10,968    16,003 
Accounts receivable - related party, net of allowance of $12 and $0, respectively   1,334    1,349 
Accounts receivable, unbilled - related party       8,021 
Inventories   8,486    9,693 
Deferred cost of products sold - related party   1,489    489 
Prepaid expenses and other current assets   8,215    10,566 
Total current assets   36,268    92,215 
Property, plant and equipment, net   21,558    19,756 
Accounts receivable, unbilled, noncurrent - related party   1,203    1,203 
Deferred cost of products sold, noncurrent - related party   9,001    2,828 
Restricted cash, noncurrent   960    960 
Recoverable taxes from Brazilian government entities   2,964    3,005 
Right-of-use assets under operating leases (Note 2)   27,645     
Other assets   5,548    7,958 
Total assets  $105,147   $127,925 
Liabilities, Mezzanine Equity and Stockholders' Deficit          
Current liabilities:          
Accounts payable  $28,604   $26,844 
Accrued and other current liabilities   33,591    28,979 
Lease liabilities (Note 2)   11,424     
Contract liabilities   8,333    8,236 
Debt, current portion (instrument measured at fair value $60,048 and $57,918, respectively)   129,393    124,010 
Related party debt, current portion   24,359    23,667 
Total current liabilities   235,704    211,736 
Long-term debt, net of current portion   42,928    43,331 
Related party debt, net of current portion   19,147    18,689 
Lease liabilities, net of current portion (Note 2)   18,850     
Derivative liabilities   3,798    42,796 
Other noncurrent liabilities   16,920    23,192 
Total liabilities   337,347    339,744 
Commitments and contingencies (Note 8)          
Mezzanine equity:          
Contingently redeemable common stock (Note 5)   5,000    5,000 
Stockholders’ deficit:          
Preferred stock - $0.0001 par value, 5,000,000 shares authorized as of March 31, 2019 and December 31, 2018, and 14,656 shares issued and outstanding as of March 31, 2019 and December 31, 2018, respectively        
Common stock - $0.0001 par value, 250,000,000 shares authorized as of March 31, 2019 and December 31, 2018; 77,210,681 and 76,564,829 shares issued and outstanding as of March 31, 2019 and December 31, 2018, respectively   8    8 
Additional paid-in capital   1,383,363    1,346,996 
Accumulated other comprehensive loss   (42,379)   (43,343)
Accumulated deficit   (1,579,129)   (1,521,417)
Total Amyris, Inc. stockholders’ deficit   (238,137)   (217,756)
Noncontrolling interest   937    937 
Total stockholders' deficit   (237,200)   (216,819)
Total liabilities, mezzanine equity and stockholders' deficit  $105,147   $127,925 

 

See the accompanying notes to the unaudited condensed consolidated financial statements.

5

 

AMYRIS, INC.

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

(Unaudited)

 

 

 

   Three Months Ended March 31,
(In thousands, except shares and per share amounts)  2019  2018
Revenue:      
Renewable products (includes related party revenue of $2 and $151, respectively)  $11,884   $5,195 
Licenses and royalties (includes related party revenue of ($380) and $7,918, respectively)   118    7,955 
Grants and collaborations (includes related party revenue of $396 and $734, respectively)   2,372    4,709 
Total revenue (includes related party revenue of $18 and $8,803, respectively)   14,374    17,859 
Cost and operating expenses:          
Cost of products sold   17,707    5,315 
Research and development   17,839    17,825 
Sales, general and administrative   28,253    18,100 
Total cost and operating expenses   63,799    41,240 
Loss from operations   (49,425)   (23,381)
Other income (expense):          
Loss on divestiture       (1,778)
Interest expense   (12,534)   (9,978)
Loss from change in fair value of derivative instruments   (2,039)   (58,357)
Loss from change in fair value of debt   (2,130)    
Other income (expense), net   (115)   692 
Total other income (expense), net   (16,818)   (69,421)
Loss before income taxes   (66,243)   (92,802)
Provision for income taxes        
Net loss attributable to Amyris, Inc.  (66,243)  (92,802)
Less: losses allocated to participating securities   2,430    7,504 
Net loss attributable to Amyris, Inc. common stockholders  $(63,813)  $(85,298)
           
Loss per share attributable to common stockholders, basic and diluted  $(0.82)  $(1.67)
Weighted-average shares of common stock outstanding used in computing loss per share of common stock, basic and diluted   77,512,059    51,200,922 

 

See the accompanying notes to the unaudited condensed consolidated financial statements.

 

6

AMYRIS, INC.

CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS

(Unaudited)

 

 

 

   Three Months Ended March 31,
(In thousands)  2019  2018
Comprehensive loss:          
Net loss attributable to Amyris, Inc.  $(66,243)  $(92,802)
Foreign currency translation adjustment   964    (137)
Comprehensive loss attributable to Amyris, Inc.  $(65,279)  $(92,939)

 

See the accompanying notes to the unaudited condensed consolidated financial statements.

 

 

 

 

 

 

7

 

AMYRIS, INC.

CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' DEFICIT AND MEZZANINE EQUITY

(Unaudited)

 

 

(In thousands, except number of shares)  Preferred Stock  Common Stock                  
   Shares  Amount  Shares  Amount  Additional Paid-in Capital  Accumulated Other Comprehensive Loss  Accumulated Deficit  Noncontrolling Interest  Total Stockholders' Deficit  Mezzanine Equity - Common Stock
Balances at December 31, 2018   14,656   $    76,564,829   $8   $1,346,996   $(43,343)  $(1,521,417)  $937   $(216,819)  $5,000 
Cumulative effect of change in accounting principle for ASU 2017-11 (see "Recently Adopted Accounting Pronouncements" in Note 1)                   32,512        8,531        41,043     
Issuance of common stock upon exercise of warrants           450,568        1                1     
Issuance of common stock upon exercise of stock options           3,612        13                13     
Issuance of common stock and payment of minimum employee taxes withheld upon net share settlement of restricted stock           191,672        (9)               (9)    
Stock-based compensation                   3,452                3,452     
Fair value of bifurcated embedded conversion feature in connection with debt modification                   398                398     
Foreign currency translation adjustment                       964            964     
Net loss                           (66,243)       (66,243)    
Balances at March 31, 2019   14,656   $    77,210,681   $8   $1,383,363   $(42,379)  $(1,579,129)  $937   $(237,200)  $5,000 
                                                   
    Preferred Stock    Common Stock                               
    Shares    Amount    Shares    Amount    Additional Paid-in Capital    Accumulated Other Comprehensive Loss    Accumulated Deficit    Noncontrolling Interest    Total Stockholders' Deficit    Mezzanine Equity - Common Stock 
Balances at December 31, 2017   22,171   $    45,637,433   $5   $1,114,546   $(42,156)  $(1,290,420)  $937   $(217,088)  $5,000 
Cumulative effect of change in accounting principle for ASC 606                           (803)       (803)    
Issuance of common stock upon exercise of warrants           162,392        835                835     
Issuance of common stock in private placement, net of issuance costs           13,529        92                92     
Issuance of common stock upon exercise of stock options           7,004        81                81     
Issuance of common stock and payment of minimum employee taxes withheld upon net share settlement of restricted stock           30,489        (66)               (66)    
Stock-based compensation                   1,278                1,278     
Other                   93                93     
Foreign currency translation adjustment                       (137)           (137)    
Net loss                           (92,802)       (92,802)    
Balances at March 31, 2018   22,171   $    45,850,847   $5   $1,116,859   $(42,293)  $(1,384,025)  $937   $(308,517)  $5,000 

 

See the accompanying notes to the unaudited condensed consolidated financial statements.

 

8

 

AMYRIS, INC.

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(Unaudited)

 

   Three Months Ended March 31,
(In thousands)  2019  2018
Operating activities      
Net loss   (66,243)   (92,802)
Adjustments to reconcile net loss to net cash used in operating activities:          
Amortization of debt discount   4,628    4,789 
Stock-based compensation   3,452    1,278 
Loss from change in fair value of debt   2,130     
Loss from change in fair value of derivative liabilities   2,039    58,357 
Amortization of right-of-use assets under operating leases   2,826     
Depreciation and amortization   848    1,561 
Write-down of property, plant and equipment   438     
Loss on disposal of property, plant and equipment   1    1,035 
(Gain) loss on foreign currency exchange rates   (108)   243 
Changes in assets and liabilities:          
Accounts receivable   5,048    74 
Accounts receivable, unbilled - related party   8,021    93 
Inventories   1,196    420 
Deferred cost of products sold   (7,173)    
Prepaid expenses and other assets   1,766    6,747 
Accounts payable   1,834    (108)
Accrued and other liabilities   6,245    (11,120)
Lease liabilities   (4,036)    
Contract liabilities   108    4,264 
Net cash used in operating activities   (36,980)   (25,169)
Investing activities          
Purchases of property, plant and equipment   (3,046)   (1,584)
Net cash used in investing activities   (3,046)   (1,584)
Financing activities          
Proceeds from issuance of debt, net of issuance costs   484     
Proceeds from exercises of common stock options   13    81 
Proceeds from exercises of warrants   1    133 
Payment of minimum employee taxes withheld upon net share settlement of restricted stock units   (9)   (66)
Principal payments on financing leases   (134)   (400)
Principal payments on debt   (577)   (6,534)
Proceeds from issuance of common stock in private placements, net of issuance costs       92 
Net cash used in financing activities   (222)   (6,694)
Effect of exchange rate changes on cash, cash equivalents and restricted cash   (70)   (68)
Net decrease in cash, cash equivalents and restricted cash   (40,318)   (33,515)
Cash, cash equivalents and restricted cash at beginning of period   47,054    61,012 
Cash, cash equivalents and restricted cash at end of the period  $6,736   $27,497 
           
Reconciliation of cash, cash equivalents and restricted cash to the condensed consolidated balance sheets          
Cash and cash equivalents  $5,153   $24,084 
Restricted cash, current   623    2,454 
Restricted cash, noncurrent   960    959 
Total cash, cash equivalents and restricted cash  $6,736   $27,497 

 

See the accompanying notes to the unaudited condensed consolidated financial statements.

9

 

AMYRIS, INC.

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS, Continued

(Unaudited)

 

 

   Three Months Ended March 31,
(In thousands)  2019  2018
Supplemental disclosures of cash flow information:      
Cash paid for interest  $3,099   $1,815 
Supplemental disclosures of non-cash investing and financing activities:          
Right-of-use assets under operating leases recorded upon adoption of ASC 842 (Note 2)  $29,713   $ 
Lease liabilities recorded upon adoption of ASC 842 (Note 2)  $33,552   $ 
Cumulative effect of change in accounting principle for ASU 2017-11 (Note 2)  $

41,043

   $ 
Acquisition of property, plant and equipment under accounts payable, accrued liabilities and notes payable  $605   $264 
Acquisition of right-of-use assets under operating leases  $

758

   $ 
Right-of-use assets amortization capitalized into inventory  $

1,800

   $ 
Accrued interest added to debt principal  $448   $1,211 
Fair value of warrants recorded as debt discount in connection with debt modification  $398   $ 
Financing of equipment  $   $91 

 

See the accompanying notes to the unaudited condensed consolidated financial statements.

 

 

 

10

 

AMYRIS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

(Unaudited)

 

1. Basis of Presentation and Summary of Significant Accounting Policies

 

Amyris, Inc. (Amyris or the Company) is a leading industrial biotechnology company that applies its technology platform to engineer, manufacture and sell high performance, natural, sustainably-sourced products into the Health & Wellness, Clean Beauty, and Flavor & Fragrance markets. The Company's proven technology platform enables the Company to rapidly engineer microbes and use them as catalysts to metabolize renewable, plant-sourced sugars into large volume, high-value ingredients. The Company's biotechnology platform and industrial fermentation process replace existing complex and expensive manufacturing processes. The Company has successfully used its technology to develop and produce several distinct molecules at commercial volumes.

 

The accompanying unaudited condensed consolidated financial statements of Amyris, Inc. should be read in conjunction with the audited consolidated financial statements and notes thereto included in the Company's Annual Report on Form 10-K/A for the year ended December 31, 2018 (the 2018 Form 10-K/A), from which the condensed consolidated balance sheet as of December 31, 2018 is derived. The accompanying condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (U.S. GAAP) for interim financial information and with the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, since they are interim statements, the accompanying condensed consolidated financial statements do not include all of the information and notes required by U.S. GAAP for complete financial statements. The accompanying condensed consolidated financial statements reflect all adjustments, consisting of normal recurring adjustments, that are, in the opinion of management, necessary to a fair statement of the results for the interim periods presented. Interim results are not necessarily indicative of results for a full year.

 

Going Concern

 

The Company has incurred significant operating losses since its inception and expects to continue to incur losses and negative cash flows from operations for at least the next 12 months following the issuance of these condensed consolidated financial statements. As of March 31, 2019, the Company had negative working capital of $199.4 million (compared to negative working capital of $119.5 million as of December 31, 2018), and an accumulated deficit of $1.6 billion.

 

As of March 31, 2019, the Company's debt (including related party debt), net of debt discount of $13.5 million, totaled $215.8 million, of which $153.8 million is classified as current. Subsequent to March 31, 2019, the Company entered into arrangements with lenders to extend maturities and convert certain debt obligations into common stock; see Note 12, "Subsequent Events" for more information. The Company's debt service obligations through March 31, 2020 are $179.8 million, including $23.5 million of anticipated cash interest payments. The Company's debt agreements contain various covenants, including certain restrictions on the Company's business that could cause the Company to be at risk of defaults, such as restrictions on additional indebtedness and cross-default clauses. A failure to comply with, or cure non-compliance events or obtain waivers for covenant violations, and other provisions of the Company’s debt instruments, including any failure to make a payment when required, would generally result in events of default under such instruments, which could permit acceleration of such indebtedness. If such indebtedness is accelerated, it would generally also constitute an event of default under the Company’s other outstanding indebtedness, permitting acceleration of a substantial portion of the Company's outstanding indebtedness.

 

Cash and cash equivalents of $5.2 million as of March 31, 2019 are not sufficient to fund expected future negative cash flows from operations and cash debt service obligations through March 31, 2020. These factors raise substantial doubt about the Company’s ability to continue as a going concern within one year after the date that these condensed consolidated financial statements are issued. The condensed consolidated financial statements do not include any adjustments that might result from the outcome of this uncertainty. The Company's ability to continue as a going concern will depend, in large part, on its ability to extend existing debt maturities by restructuring a majority of its convertible debt, which is uncertain and outside the control of the Company. Further, the Company's operating plan for the twelve months ending March 31, 2020 contemplates a significant reduction in its net operating cash outflows as compared to the year ended December 31, 2018, resulting from (i) revenue growth from sales of existing and new products with positive gross margins, (ii) significantly increased cash inflows from grants and collaborations, and (iii) reduced production costs as a result of manufacturing and technical developments. If the Company is unable to complete these actions, it expects to be unable to meet its operating cash flow needs and its obligations under its existing debt facilities. This could result in an acceleration of its obligation to repay all amounts outstanding under those facilities, and it may be required to obtain additional equity or debt financing, which may not occur timely or on reasonable terms, if at all, and/or liquidate its assets. In such a scenario, the value the Company receives for its assets in liquidation or dissolution could be significantly lower than the value reflected in these condensed consolidated financial statements.

 

11

On September 16, 2019, the Company failed to pay an aggregate of $63.6 million of outstanding principal and accrued interest on the Second Exchange Note when due. The failure resulted in an event of default under the Second Exchange Note and also triggered cross-defaults under other debt instruments of the Company which permitted the holders of such indebtedness to accelerate the amounts owing under such instruments. The Company subsequently received waivers from substantially all holders of such other debt instruments to waive the right to accelerate. As a result, the indebtedness with respect to which the Company has obtained such waivers continues to be classified as long-term on the Company’s balance sheet.  The indebtedness reflected by the Second Exchange Note continues to be classified as a current liability on the Company’s balance sheet. In addition, as a result of the payment default, the conversion price of the Second Exchange Note is subject to adjustment in accordance with the terms of the Second Exchange Note.

 

The Company does not currently have sufficient funds to repay the amounts outstanding under the Second Exchange Note. To date, negotiations with the holder of the Second Exchange Note have not been successful, and there can be no assurance that a favorable outcome for the Company will be reached. The Company has executed a term sheet with an existing investor for a term loan, the proceeds of which would be used to repay a portion of the Second Exchange Note. However, there can be no assurance that the Company will be able to obtain such financing on its expected timeline, or on acceptable terms, if at all. Even if the Company does obtain such financing, it will not have sufficient funds to repay the Second Exchange Note in full without obtaining additional financing, which the Company is attempting to source. The condensed consolidated financial statements do not include any adjustments that might result from the outcome of this uncertainty.

 

Significant Accounting Policies

 

Note 1, "Basis of Presentation and Summary of Significant Accounting Policies", to the audited consolidated financial statements in the 2018 Form 10-K/A includes a discussion of the significant accounting policies and estimates used in the preparation of the Company’s consolidated financial statements. There have been no material changes to the Company's significant accounting policies and estimates during the three months ended March 31, 2019, except for the Company's adoption of these accounting standards on January 1, 2019:

     Accounting Standards Codification (ASC) Topic 842 (ASC 842), Leases; and

     Accounting Standards Update (ASU) 2017-11, Earnings Per Share (Topic 260); Distinguishing Liabilities from Equity (Topic 480); Derivatives and Hedging (Topic 815): Accounting for Certain Financial Instruments with Down Round Features

 

Revenue Recognition

 

The Company recognizes revenue from the sale of renewable products, licenses of and royalties from intellectual property, and grants and collaborative research and development services. Revenue is measured based on the consideration specified in a contract with a customer and recognized when, or as, the Company satisfies a performance obligation by transferring control over a product or service to a customer. The Company generally does not incur costs to obtain new contracts. The costs to fulfill a contract are expensed as incurred.

 

The Company accounts for a contract when it has approval and commitment to perform from both parties, the rights of the parties are identified, payment terms are established, the contract has commercial substance and collectability of the consideration is probable. Changes to contracts are assessed for whether they represent a modification or should be accounted for as a new contract. The Company considers the following indicators among others when determining whether it is acting as a principal in the transaction and recording revenue on a gross basis: (i) the Company is primarily responsible for fulfilling the promise to provide the specified goods or service, (ii) the Company has inventory risk before the specified good or service has been transferred to a customer or after transfer of control to the customer and (iii) the Company has discretion in establishing the price for the specified good or service. If a transaction does not meet the Company's indicators of being a principal in the transaction, then the Company is acting as an agent in the transaction and the associated revenues are recognized on a net basis.

 

The Company’s significant contracts and contractual terms with its customers are presented in Note 10, "Revenue Recognition" in Part II, Item 8 of the 2018 Form 10-K/A.

 

The Company recognizes revenue when control has passed to the customer. The following indicators are evaluated in determining when control has passed to the customer: (i) the Company has a right to payment for the product or service, (ii) the customer has legal title to the product, (iii) the Company has transferred physical possession of the product to the customer, (iv) the customer has the significant risk and rewards of ownership of the product and (v) the customer has accepted the product. The Company’s renewable products are delivered to customers from the Company’s facilities with shipping terms typically specifying F.O.B. shipping point.

 

12

Performance Obligations

 

A performance obligation is a promise in a contract to transfer a distinct good or service to the customer. A contract’s transaction price is allocated to each distinct performance obligation and recognized as revenue when, or as, the performance obligation is satisfied. The Company's contracts may contain multiple performance obligations if a promise to transfer the individual goods or services is separately identifiable from other promises in the contracts and, therefore, is considered distinct. For contracts with multiple performance obligations, the Company determines the standalone selling price of each performance obligation and allocates the total transaction price using the relative selling price basis.

 

The following is a description of the principal goods and services from which the Company generates revenue.

 

Renewable Product Sales

 

Revenues from renewable product sales are recognized as a distinct performance obligation on a gross basis as the Company is acting as a principal in these transactions, with the selling price to the customer recorded net of discounts and allowances. Revenues are recognized at a point in time when control has passed to the customer, which typically is upon the renewable products leaving the Company’s facilities with the first transportation carrier. The Company, on occasion, may recognize revenue under a bill and hold arrangement, whereby the customer requests and agrees to purchase product but requests delivery at a later date. Under these arrangements, control transfers to the customer when the product is ready for delivery, which occurs when the product is identified separately as belonging to the customer, the product is ready for shipment to the customer in its current form, and the Company does not have the ability to direct the product to a different customer. It is at this point that the Company has the right to payment, the customer obtains legal title, and the customer has the significant risks and rewards of ownership. The Company’s renewable product sales do not include rights of return. Returns are accepted only if the product does not meet product specifications and such nonconformity is communicated to the Company within a set number of days of delivery. The Company offers a two-year assurance-type warranty to replace squalane products that do not meet Company-established criteria as set forth in the Company’s trade terms. An estimate of the cost to replace the squalane products sold is made based on a historical rate of experience and recognized as a liability and related expense when the renewable product sale is consummated.

 

Licenses and Royalties

 

Licensing of Intellectual Property: When the Company’s intellectual property licenses are determined to be distinct from the other performance obligations identified in the arrangement, revenue is recognized from non-refundable, up-front fees allocated to the license at a point in time when the license is transferred to the licensee and the licensee is able to use and benefit from the license. For intellectual property licenses that are combined with other promises, the Company utilizes judgment to assess the nature of the combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purposes of recognizing revenue from non-refundable, up-front-fees. The Company evaluates the measure of progress each reporting period and, if necessary, adjusts the measure of performance and related revenue recognized.

 

Royalties from Licensing of Intellectual Property: The Company earns royalties from the licensing of its intellectual property whereby the licensee uses the intellectual property to produce and sell its products to its customers and the Company shares in the profits.

 

When the Company’s intellectual property license is the only performance obligation, or it is the predominant performance obligation in arrangements with multiple performance obligations, the Company applies the sales-based royalty exception and revenue is estimated and recognized at a point in time when the licensee’s product sales occur. Estimates of sales-based royalty revenues are made using the most likely amount method, which is the single amount in a range of possible amounts derived from the licensee’s historical sales volumes and sales prices of its products and recent commodity market pricing data and trends.

 

When the Company’s intellectual property license is not the predominant performance obligation in arrangements with multiple performance obligations, the royalty represents variable consideration and is allocated to the transaction price of the predominant performance obligation which generally is the supply of renewable products to the Company's customers. Revenue is estimated and recognized at a point in time when the renewable products are delivered to the customer. Estimates of the amount of variable consideration to include in the transaction price are made using the expected value method, which is the sum of probability-weighted amounts in a range of possible amounts determined based on the cost to produce the renewable product plus a reasonable margin for the profit share. The Company only includes an amount of variable consideration in the transaction price to the extent it is probable that a significant reversal in the cumulative revenue recognized will not occur when the uncertainty associated with the variable consideration is subsequently resolved. Also, the transaction price is reduced for estimates of customer incentive payments payable by the Company for certain customer contracts.

 

13

Grants and Collaborative Research and Development Services

 

Collaborative Research and Development Services: The Company earns revenues from collaboration agreements with customers to perform research and development services to develop new molecules using the Company’s technology and to scale production of the molecules for commercialization and use in the collaborator’s products. The collaboration agreements generally include providing the Company's collaborators with research and development services and with licenses to the Company’s intellectual property to use the technology underlying the development of the molecules and to sell its products that incorporate the technology. The terms of the Company's collaboration agreements typically include one or more of the following: advance payments for the research and development services that will be performed, nonrefundable upfront license payments, milestone payments to be received upon the achievement of the milestone events defined in the agreements, and royalty payments upon the commercialization of the molecules in which the Company shares in the customer’s profits.

 

Collaboration agreements are evaluated at inception to determine whether the intellectual property licenses represent distinct performance obligations separate from the research and development services. If the licenses are determined to be distinct, the non-refundable upfront license fee is recognized as revenue at a point in time when the license is transferred to the licensee and the licensee is able to use and benefit from the license while the research and development service fees are recognized over time as the performance obligations are satisfied. The research and development service fees represent variable consideration. Estimates of the amount of variable consideration to include in the transaction price are made using the expected value method, which is the sum of probability-weighted amounts in a range of possible amounts. The Company only includes an amount of variable consideration in the transaction price to the extent it is probable that a significant reversal in the cumulative revenue recognized will not occur when the uncertainty associated with the variable consideration is subsequently resolved. Revenue is recognized over time using either an input-based measure of labor hours expended or a time-based measure of progress towards the satisfaction of the performance obligations. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized.

 

Collaboration agreements that include milestone payments are evaluated at inception to determine whether the milestone events are considered probable of achievement and estimates are made of the amount of the milestone payments to include in the transaction price using the most likely amount method which is the single amount in a range of possible amounts. If it is probable that a significant revenue reversal will not occur, the estimated milestone payment amount is included in the transaction price. Each reporting period, the Company re-evaluates the probability of achievement of the milestone events and any related constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative basis, which would affect collaboration revenues in the period of adjustment. Generally, revenue is recognized using an input-based measure of progress towards the satisfaction of the performance obligations which can be labor hours expended or time-based in proportion to the estimated total project effort or total projected time to complete. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized. Certain performance obligations are associated with milestones agreed between the Company and its customer. Revenue generated from the performance of services in accordance with the milestones in these agreements is recognized upon confirmation from the customer that the milestone has been achieved. In these cases, amounts recognized are constrained to the amount of consideration received upon achievement of the milestone.

 

The Company generally invoices its collaborators on a monthly or quarterly basis, or upon the completion of the effort or achievement of a milestone, based on the terms of each agreement. Contract liability arises from amounts received in advance of performing the research and development activities and is recognized as revenue in future periods as the performance obligations are satisfied.

 

Grants: The Company earns revenues from grants with government agencies to, among other things, provide research and development services to develop molecules using the Company’s technology, and create research and development tools to improve the timeline and predictability for scaling molecules from proof of concept to market by reducing time and costs. Grants typically consist of research and development milestone payments to be received upon the achievement of the milestone events defined in the agreements.

 

The milestone payments are evaluated at inception to determine whether the milestone events are considered probable of achievement and estimates are made of the amount of the milestone payments to include in the transaction price using the most likely amount method which is the single amount in a range of possible amounts. If it is probable that a significant revenue reversal will not occur, the estimated milestone payment amount is included in the transaction price. Each reporting period, the Company re-evaluates the probability of achievement of the milestone events and any related constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative basis, which would affect collaboration revenues in the period of adjustment. Revenue is recognized over time using a time-based measure of progress towards the satisfaction of the performance obligations. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized.

 

14

For descriptions of the Company's other significant accounting policies, see the 2018 Form 10-K/A.

 

Accounting Standards or Updates Recently Adopted

 

In the three months ended March 31, 2019, the Company adopted these accounting standards or updates:

 

Leases In February 2016, the FASB issued ASU No. 2016-02, Leases (Topic 842). The standard requires the recognition of lease liabilities and right-of-use (ROU) assets on the balance sheet arising from lease transactions at the lease commencement date and the disclosure of key information about leasing arrangements. In July 2018, the FASB issued ASU 2018-11, Leases (Topic 842) Targeted Improvements, which provides an additional transition method in which the lease standard is applied at the adoption date and recognized as a cumulative-effect adjustment to retained earnings without adjustment to comparative periods (collectively Topic 842). The amendment has the same effective date and transition requirements as the lease standard.

 

The Company adopted this standard on January 1, 2019 using the modified retrospective approach and elected the package of practical expedients permitted under transition guidance, which allowed the Company to carry forward its historical assessments of: (1) whether contracts are or contain leases, (2) lease classification and (3) initial direct costs, where applicable. The Company did not elect the practical expedient allowing the use-of-hindsight which would require the Company to reassess the lease term of its leases based on all facts and circumstances through the effective date and did not elect the practical expedient pertaining to land easements as this is not applicable to the Company’s current contracts. The Company elected the post-transition practical expedient to not separate lease components from non-lease components for all leases of manufacturing equipment. The Company also elected a policy of not recording leases on its condensed consolidated balance sheets when the leases have a term of 12 months or less and the Company is not reasonably certain to elect an option to purchase the leased asset.

 

The adoption of this standard had the effect of increasing assets and liabilities on the condensed consolidated balance sheet by $25.7 million, but did not have a material impact on the condensed consolidated statements of operations or cash flows.  The most significant impact relates to (1) the recognition of new ROU assets and lease liabilities on the balance sheet for operating leases; and (2) providing significant new disclosures about leasing activities.

 

Upon adoption, the Company recognized operating lease liabilities of $33.6 million, based on the present value of the remaining minimum rental payments under current leasing standards for existing operating leases. The Company also recognized ROU assets of $29.7 million, which represents the operating lease liability, adjusted for prepaid expenses and deferred rent. The difference between the operating lease ROU assets and lease liabilities reflects the net of advanced rent payments and deferred rent balances that were derecognized at the time of adoption.

 

Financial Instruments with "Down Round" Features In July 2017, the FASB issued ASU 2017-11, Earnings Per Share (Topic 260); Distinguishing Liabilities from Equity (Topic 480); Derivatives and Hedging (Topic 815): Accounting for Certain Financial Instruments with Down Round Features. The amendments of this ASU update the classification analysis of certain equity-linked financial instruments, or embedded features, with down round features, as well as clarify existing disclosure requirements for equity-classified instruments. When determining whether certain financial instruments should be classified as liabilities or equity instruments, a down round feature no longer precludes equity classification when assessing whether the instrument is indexed to an entity’s own stock. The accounting standard update became effective in the first quarter of fiscal year 2019, and the Company adopted the standard using a modified retrospective approach. Since the adoption of ASU 2017-11 would have classified the warrants effected as equity at inception, the cumulative-effect adjustment should (i) record the issuance date value of the warrants as if they had been equity classified at the issuance date, (ii) reverse the effects of changes in the fair value of the warrants that had been recorded in the statement of operations of each period, and (iii) eliminate the derivative liabilities from the balance sheet. Upon adoption, the Company (i) recorded an increase of $32.5 million to additional paid-in capital, (ii) recorded a decrease to accumulated deficit of $8.5 million and (iii) decreased the warrant liability by $41.0 million.

 

Recent Accounting Standards or Updates Not Yet Effective

 

Fair Value Measurement In August 2018, the FASB issued ASU 2018-13, Fair Value Measurement (Topic 820): Disclosure Framework—Changes to the Disclosure Requirements for Fair Value Measurement, which amends ASC 820, Fair Value Measurement. ASU 2018-13 modifies the disclosure requirements for fair value measurements by removing, modifying or adding certain disclosures. The accounting standard update will be effective beginning in the first quarter of fiscal 2020, with removed and modified disclosures to be adopted on a retrospective basis, and new disclosures to be adopted on a prospective basis. The Company is in the initial stages of evaluating the impact of the standard on its condensed consolidated financial statements.

 

Collaborative Revenue Arrangements In November 2018, the FASB issued ASU 2018-18, Clarifying the Interaction between Topic 808 and Topic 606, that clarifies the interaction between the guidance for certain collaborative arrangements and Topic 606, the new revenue recognition standard. A collaborative arrangement is a contractual arrangement under which two or more parties actively participate in a joint operating activity and are exposed to significant risks and rewards that depend on the activity’s commercial success. The ASU provides guidance on how to assess whether certain transactions between collaborative arrangement participants should be accounted for within the revenue recognition standard. The accounting standard update will be effective beginning in the first quarter of fiscal year 2020 retroactively. The Company does not believe that the impact of the new standard on its condensed consolidated financial statements will be material.

 

Credit Losses In June 2016, the FASB issued ASU 2016-13, Financial Instruments—Credit Losses (Topic 326), Measurement of Credit Losses on Financial Instruments. ASU 2016-13 requires entities to measure all expected credit losses for most financial assets held at the reporting date based on an expected loss model which includes historical experience, current conditions, and reasonable and supportable forecasts. Entities will now use forward-looking information to better form their credit loss estimates. ASU 2016-13 also requires enhanced disclosures to help financial statement users better understand significant estimates and judgments used in estimating credit losses, as well as the credit quality and underwriting standards of an entity's portfolio. ASU 2016-13 will become effective for the Company beginning in the first quarter of fiscal year 2020. The Company does not believe that the impact of the new standard on its condensed consolidated financial statements will be material.

 

15

Use of Estimates and Judgements

 

The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates, judgements and assumptions that affect the reported amounts of assets and liabilities, disclosures of contingent assets and liabilities at the date of the condensed consolidated financial statements, and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates, and such differences may be material to the condensed consolidated financial statements.

 

2. Balance Sheet Details

 

Inventories

 

(In thousands)  March 31, 2019  December 31, 2018
Raw materials  $2,451   $3,901 
Work-in-process   238    539 
Finished goods   5,797    5,253 
Inventories  $8,486   $9,693 

 

Deferred cost of products sold - related party

 

(In thousands)  March 31, 2019  December 31, 2018
Deferred cost of products sold - related party  $1,489   $489 
Deferred cost of products sold, noncurrent - related party   9,001    2,828 
Total  $10,490   $3,317 

 

In November 2018, the Company amended the supply agreement with DSM to secure capacity at the Brotas 1 facility for sweetener production through 2022. See Note 10, “Revenue Recognition” in Part II, Item 8 of the 2018 Form 10-K/A for information regarding the November 2018 Supply Agreement Amendment. The supply agreement was included as an element of a combined transaction with DSM, which resulted in a fair value allocation of $24.4 million to the manufacturing capacity fees, of which $3.3 million was recorded as deferred cost of products sold at December 31, 2018. During the three months ended March 31, 2019, the Company paid an additional $7.3 million of reservation capacity fees, which was recorded as additional deferred cost of products sold. The remaining $13.8 million capacity fees will be recorded as deferred cost of products sold in the period the additional payments are made to DSM. The deferred cost of products sold asset is expensed to cost of products sold on a units of production basis as the Company's sweetener product is sold over the five-year term of the supply agreement. Each quarter, the Company evaluates its future production volumes and adjusts the unit cost to be expensed over the remaining estimated production volume. Due to the Company's commercial launch of the product in December 2018, amortization of the deferred cost of products sold asset has been insignificant through March 31, 2019. The deferred cost of products sold asset is evaluated for recoverability at each period end.

 

Prepaid expenses and other current assets

 

(In thousands)  March 31, 2019  December 31, 2018
Prepayments, advances and deposits  $3,310   $5,644 
Recoverable taxes from Brazilian government entities   956    631 
Other   3,949    4,291 
Total prepaid expenses and other current assets  $8,215   $10,566 

 

Property, Plant and Equipment, Net

 

(In thousands)  March 31, 2019  December 31, 2018
Machinery and equipment  $45,874   $43,713 
Leasehold improvements   39,951    39,922 
Computers and software   10,138    9,987 
Furniture and office equipment, vehicles and land   3,279    3,016 
Construction in progress   1,460    1,749 
Total property, plant and equipment, gross   100,702    98,387 
Less: accumulated depreciation and amortization   (79,144)   (78,631)
Property, plant and equipment, net  $21,558   $19,756 

 

During the three months ended March 31, 2019 and 2018, the Company capitalized $0.2 million and $0.8 million, respectively, of internal labor costs required to automate, integrate and ready certain laboratory and plant equipment for its intended use.

 

Depreciation and amortization expense, including amortization of assets under financing leases, was $0.8 million and $1.6 million for the three months ended March 31, 2019 and 2018, respectively.

 

16

 

Leases

 

Operating Leases

 

The Company has entered into operating leases primarily for administrative offices, laboratory equipment and other facilities. The operating leases have remaining terms that range from 1 year to 5 years, and often include one or more options to renew. These renewal terms can extend the lease term from 1 to 5 years and are included in the lease term when it is reasonably certain that the Company will exercise the option. The operating leases are classified as Right-of-use (ROU) assets under operating leases on the Company's March 31, 2019 Condensed Consolidated Balance Sheet and represent the Company’s right to use the underlying asset for the lease term. The Company’s obligation to make operating lease payments is included in "Lease liabilities" and "Lease liabilities, net of current portion" on the Company's March 31, 2019 Condensed Consolidated Balance Sheet. Based on the present value of the lease payments for the remaining lease term of the Company's existing leases, the Company recognized right-of-use assets of $29.7 million and lease liabilities for operating leases of $33.6 million on January 1, 2019. Operating lease right-of-use assets and liabilities commencing after January 1, 2019 are recognized at commencement date based on the present value of lease payments over the lease term. As of March 31, 2019, total right-of-use assets and operating lease liabilities were $27.6 million and $29.7 million, respectively. All operating lease expense is recognized on a straight-line basis over the lease term. In the three months ended March 31, 2019, the Company recorded $2.8 million of operating lease amortization that was charged to expense, and $1.8 million of operating lease amortization for certain contract manufacturing arrangements that was capitalized to inventory.

 

Because the rate implicit in each lease is not readily determinable, the Company uses its incremental borrowing rate to determine the present value of the lease payments. The Company has certain contracts for real estate and marketing which may contain lease and non-lease components which it has elected to treat as a single lease component.

 

Information related to the Company's right-of-use assets and related lease liabilities were as follows:

 

Amounts in thousands  Three Months Ended March 31, 2019
Cash paid for operating lease liabilities  $5,305 
Right-of-use assets obtained in exchange for new operating lease obligations(1)  $30,472 
Weighted-average remaining lease term (in years)   2.7 
Weighted-average discount rate   18.0%

 

(1) Includes $29.7 million for operating leases existing on January 1, 2019 and $0.8 million for operating leases that commenced in the first quarter of 2019.

 

Financing Leases

 

The Company has entered into financing leases primarily for laboratory and computer equipment. Assets purchased under financing leases are included in "Property, plant and equipment, net" on the condensed consolidated balance sheets. For financing leases, the associated assets are depreciated or amortized over the shorter of the relevant useful life of each asset or the lease term. Property, plant and equipment, net included $5.3 million and $5.0 million of machinery and equipment under financing leases as of March 31, 2019 and December 31, 2018, respectively. Accumulated amortization of assets under financing leases totaled $2.5 million and $2.3 million as of March 31, 2019 and December 31, 2018, respectively.

 

Maturities of Financing and Operating Leases

 

Maturities of lease liabilities as of March 31, 2019 were as follows:

 

Years ending December 31:
(In thousands)
  Financing Leases  Operating
Leases
  Total Leases
2019 (remaining nine months)  $368   $12,755   $13,123 
2020   199    9,109    9,308 
2021   1    7,226    7,227 
2022       7,398    7,398 
2023       3,034    3,034 
Thereafter            
Total lease payments   568    39,522    40,090 

Less: amount representing interest

   (23)   (9,793)   (9,816)
Total lease liability  $545   $29,729   $30,274 
                
Current lease liability  $452   $10,972   $11,424 
Noncurrent lease liability   93    18,757    18,850 
Total lease liability  $545   $29,729   $30,274 

 

17

 

Other Assets

 

(In thousands)  March 31, 2019  December 31, 2018
Contingent consideration  $4,286   $4,286 
Deposits   145    2,465 
Other   1,117    1,207 
Other assets  $5,548   $7,958 

 

Accrued and Other Current Liabilities

 

(In thousands)  March 31, 2019  December 31, 2018
DSM manufacturing capacity fee  $

7,250

   $ 
Contract termination fees  5,337   6,247 
Accrued interest   7,094    3,853 
Payroll and related expenses   5,285    9,220 
Asset retirement obligation   3,111    3,063 
Tax-related liabilities   2,589    2,139 
Professional services   1,871    1,173 
Other   1,054    3,284 
Total accrued and other current liabilities  $33,591   $28,979 

 

Other noncurrent liabilities

 

(In thousands)  March 31, 2019  December 31, 2018
Contract termination fees, net of current portion  $8,207   $7,715 
Liability for unrecognized tax benefit   6,582    6,582 
Contract liability, net of current portion (Note 9)   1,449    1,587 
Deferred rent, net of current portion(1)       6,440 
Other   682    868 
Total other noncurrent liabilities  $16,920   $23,192 

 

(1)     Deferred rent at December 31, 2018 was reclassified to ROU asset upon the adoption on January 1, 2019 of ASC 842, "Leases".

 

3. Fair Value Measurement

 

Assets and Liabilities Measured and Recorded at Fair Value on a Recurring Basis

 

The following tables summarize assets and liabilities measured at fair value, and the respective fair value by input classification level within the fair value hierarchy:

 

(In thousands)  March 31, 2019  December 31, 2018
   Level 1  Level 2  Level 3  Total  Level 1  Level 2  Level 3  Total
Liabilities                        
6% Convertible Notes Due 2021  $   $   $60,048   $60,048   $   $   $57,918   $57,918 
Freestanding derivative instruments in connection with the issuance of equity instruments           3,798    3,798            42,796    42,796 
Total liabilities measured and recorded at fair value  $   $   $63,846   $63,846   $   $   $100,714   $100,714 

 

There were no transfers between levels during the periods presented.

 

18

6% Convertible Notes Due 2021

 

The Company issued $60.0 million of 6% Convertible Notes Due 2021 on December 10, 2018 and elected the fair value option of accounting for this instrument. At March 31, 2019, outstanding principal was $60.0 million, and the fair value was $60.0 million, which was measured using a binomial lattice model and assuming a 23.8% discount yield, 45% equity volatility, 50% / 50% probability of principal repayment in cash / stock, and 5% probability of change in control. See Note 4, “Debt” for further information related to this debt instrument. For the three months ended March 31, 2019, the Company recorded a $2.1 million loss from change in fair value of debt in connection with the 6% Convertible Notes Due 2021, as follows:

 

In thousands   
Fair value at December 31, 2018  $57,918 
Change in fair value   2,130 
Fair value at March 31, 2019  $60,048 

 

Derivative Liabilities Recognized in Connection with the Issuance of Debt and Equity Instruments

 

The following table provides a reconciliation of the beginning and ending balances for the Company's derivative liabilities recognized in connection with the issuance of debt and equity instruments, measured at fair value using significant unobservable inputs (Level 3):

 

(In thousands)  Equity-related Derivative Liability  Debt-related Derivative Liability  Total Derivative Liability
Balance at December 31, 2018  $41,272   $1,524   $42,796 
Derecognition upon adoption of ASU 2017-11   (39,513)   (1,524)   (41,037)
Change in fair value of derivative liabilities   2,039        2,039 
Balance at March 31, 2019  $3,798   $   $3,798 

 

As of March 31, 2019, the remaining derivative liabilities are in connection with the November 2018 Securities Purchase Agreement with DSM. See Note 10, “Revenue Recognition” in Part II, Item 8 of the 2018 10-K/A. This make-whole provision is effectively marked to market through the condensed consolidated statements of operations, based on the Company’s closing stock price at each reporting period until converted into common stock or cash settled. The fair value of these instruments is directly affected by the volatility of the Company’s stock price between each reporting period or conversion date, if settled during the reporting period.

 

Assets and Liabilities Recorded at Carrying Value

 

Financial Assets and Liabilities

 

The carrying amounts of certain financial instruments, such as cash equivalents, accounts receivable, accounts payable and accrued liabilities, approximate fair value due to their relatively short maturities and low market interest rates, if applicable. Loans payable, credit facilities and convertible notes are recorded at carrying value (except for the 6% Convertible Notes Due 2021, which are recorded at fair value), which is representative of fair value at the date of acquisition. For loans payable and credit facilities recorded at carrying value, the Company estimates fair value using observable market-based inputs (Level 2); for convertible notes, the Company estimates fair value based on rates currently offered for instruments with similar maturities and terms (Level 3). The carrying amount (the total amount of net debt presented on the balance sheet) of the Company's debt at March 31, 2019, excluding the 6% Convertible Notes that the Company records at fair value, was $155.8 million. The fair value of such debt at March 31, 2019 was $155.8 million, and was determined by (i) discounting expected cash flows using current market discount rates estimated for certain of the debt instruments and (ii) using third-party fair value estimates for the remaining debt instruments.

 

19

4. Debt

 

Net carrying amounts of debt are as follows:

 

   March 31, 2019  December 31, 2018
(In thousands)  Principal  Unamortized Debt (Discount) Premium  Change in Fair Value  Net Balance  Principal  Unamortized Debt (Discount) Premium  Change in Fair Value  Net Balance
Convertible notes payable                                        
6% convertible notes due 2021  $60,000   $   $48   $60,048   $60,000   $   $(2,082)  $57,918 
2015 Rule 144A convertible notes   37,887    (358)       37,529    37,887    (2,413)       35,474 
2014 Rule 144A convertible notes   24,004    (289)       23,715    24,004    (867)       23,137 
August 2013 financing convertible note   4,863    (596)       4,267    4,415    (70)       4,345 
    126,754    (1,243)   48    125,559    126,306    (3,350)   (2,082)   120,874 
Related party convertible notes payable                                        
2014 Rule 144A convertible notes   24,705    (346)       24,359    24,705    (1,038)       23,667 
                                         
Loans payable and credit facilities                                        
GACP secured term loan facility   36,000    (1,208)       34,792    36,000    (1,349)       34,651 
Ginkgo note   12,000    (3,832)       8,168    12,000    (4,047)       7,953 
Other loans payable   4,813    (1,011)       3,802    4,910    (1,047)       3,863 
    52,813    (6,051)       46,762    52,910    (6,443)       46,467 
Related party loans payable                                        
DSM note   25,000    (5,853)       19,147    25,000    (6,311)       18,689 
Total debt  $229,272   $(13,493)  $48    215,827   $228,921   $(17,142)  $(2,082)   209,697 
Less: current portion                  (153,752)                  (147,677)
Long-term debt, net of current portion                 $62,075                  $62,020 

 

The 6% convertible notes due 2021 have been classified as current in the March 31, 2019 and December 31, 2018 balance sheets, due to certain events subsequent to March 31, 2019 but prior to the issuance of the March 31, 2019 and December 31, 2018 financial statements. See Note 12, "Subsequent Events" for additional information.

 

On January 14, 2019, Wolverine Flagship Fund Trading Limited (Wolverine) agreed to waive payment of the August 2013 Financing Convertible Note held by Wolverine at its January 15, 2019 maturity until July 15, 2019 in exchange for a fee, payable on or prior to July 15, 2019, of $0.6 million. The Company concluded that the term extension represented a debt modification, and the fee was accounted for as additional debt discount to be amortized over the remaining term. Effective July 15, 2019, the due date of the waiver fee was extended to October 13, 2019 and will bear interest at a rate of 1.75% per month, compounded, from July 16, 2019 to the date of payment. See Note 12, “Subsequent Events” for additional information.

 

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Future Minimum Payments

 

Future minimum payments under the Company's debt agreements as of March 31, 2019 are as follows:

 

(In thousands)  Convertible
Notes
  Loans
Payable
and Credit
Facilities
  Related
Party
Convertible
Notes
  Related
Party Loans
Payable and
Credit
Facilities
  Total
2019 (remaining nine months)  $139,303   $9,689   $25,618   $1,875   $176,485 
2020       10,113        2,500    12,613 
2021       34,776        28,146    62,922 
2022       13,450            13,450 
2023       399            399 
Thereafter       2,268            2,268 
Total future minimum payments   139,303    70,695    25,618    32,521    268,137 
Less: amount representing interest   (12,303)   (17,883)   (913)   (7,521)   (38,620)
Less: future conversion of accrued interest to principal   (245)               (245)
Present value of minimum debt payments   126,755    52,812    24,705    25,000    229,272 
Less: current portion of debt principal   (126,755)   (4,513)   (24,705)       (155,973)
Noncurrent portion of debt principal  $   $48,299   $   $25,000   $73,299 

 

5. Mezzanine Equity

 

Mezzanine equity is comprised of the following:

 

(In thousands)  March 31, 2019  December 31, 2018
Contingently redeemable common stock  $5,000   $5,000 

 

Mezzanine equity at March 31, 2019 and December 31, 2018 is comprised of proceeds from shares of common stock sold on May 10, 2016 to the Bill & Melinda Gates Foundation (Gates Foundation). In connection with the stock sale, the Company and the Gates Foundation entered into an agreement under which the Company agreed to expend an aggregate amount not less than the proceeds from the stock sale to develop a yeast strain that produces artemisinic acid and/or amorphadiene at a low cost and to supply such artemisinic acid and amorphadiene to companies qualified to convert artemisinic acid and amorphadiene to artemisinin for inclusion in artemisinin combination therapies used to treat malaria. If the Company defaults in its obligation to use the proceeds from the stock sale as set forth above or defaults under certain other commitments in the agreement, the Gates Foundation will have the right to request that the Company redeem, or facilitate the purchase by a third party, the shares then held by the Gates Foundation at a price per share equal to the greater of (i) the closing price of the Company’s common stock on the trading day prior to the redemption or purchase, as applicable, or (ii) an amount equal to $17.10 plus a compounded annual return of 10%.

 

As of March 31, 2019, the Company's remaining research and development obligation under this arrangement was $0.6 million.

 

6. Stockholders' Deficit

 

Warrants

 

In connection with various debt and equity transactions (see Note 5, "Debt" and Note 7, “Stockholders’ Deficit” in Part II, Item 8 of the 2018 Form 10-K/A), the Company has issued warrants exercisable for shares of common stock. The following table summarizes warrant activity for the three months ended March 31, 2019:

 

Transaction  Number Outstanding as of December 31, 2018  Additional Warrants Issued  Exercises  Number Outstanding as of March 31, 2019
August 2018 warrant exercise agreements   12,097,164            12,097,164 
May 2017 cash and dilution warrants   6,292,798            6,292,798 
August 2017 cash and dilution warrants   3,968,116            3,968,116 
April 2018 warrant exercise agreements   3,616,174            3,616,174 
July 2015 related party debt exchange   663,228        (471,204)   192,024 
February 2016 related party private placement   171,429            171,429 
July 2015 private placement   81,197        (8,547)   72,650 
Other   1,406            1,406 
    26,891,512        (479,751)   26,411,761 

 

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For the three months ended March 31, 2019, 479,751 shares of common stock were issued under certain anti-dilution warrants with an exercise price of $0.01 and resulted in no proceeds to the Company. The shares were exercised through net share settlement, resulting in the issuance of 450,568 shares.

 

7. Loss Per Share

 

For the three months ended March 31, 2019 and March 31, 2018, basic loss per share was the same as diluted loss per share, because the inclusion of all potentially dilutive securities outstanding was antidilutive.

 

The Company follows the two-class method when computing net loss per common share when shares are issued that meet the definition of participating securities. The two-class method requires income available to common stockholders for the period to be allocated between common stock and participating securities based upon their respective rights to receive dividends as if all income for the period had been distributed. The two-class method also requires losses for the period to be allocated between common stock and participating securities based on their respective rights if the participating security contractually participates in losses. The Company’s convertible preferred stock are participating securities as they contractually entitle the holders of such shares to participate in dividends and contractually require the holders of such shares to participate in the Company’s losses.

 

The following table presents the calculation of basic and diluted loss per share:

 

   Three Months Ended March 31,
(In thousands, except shares and per share amounts)  2019  2018
Numerator:      
Net loss attributable to Amyris, Inc.  $(66,243)  $(92,802)
Less: losses allocated to participating securities   2,430    7,504 
Net loss attributable to Amyris, Inc. common stockholders  $(63,813)  $(85,298)
           
Denominator:          
Weighted-average shares of common stock outstanding used in computing loss per share of common stock, basic and diluted   77,512,059    51,200,922 
Loss per share attributable to common stockholders, basic and diluted  $(0.82)  $(1.67)

 

The following outstanding shares of potentially dilutive securities were excluded from the computation of diluted loss per share of common stock because including them would have been antidilutive:

 

   Three Months Ended March 31,
   2019  2018
Period-end stock options to purchase common stock   5,427,384    1,365,447 
Convertible promissory notes(1)   12,699,607    8,347,364 
Period-end common stock warrants   26,411,761    29,759,452 
Period-end restricted stock units   5,493,579    706,697 
Period-end preferred stock   2,955,732    4,504,212 
Total potentially dilutive securities excluded from computation of diluted loss per share   52,988,063    44,683,172 

______________

(1)The potentially dilutive effect of convertible promissory notes was computed based on conversion ratios in effect as of the respective period end dates. A portion of the convertible promissory notes issued carries a provision for a reduction in conversion price under certain circumstances, which could potentially increase the dilutive shares outstanding. Another portion of the convertible promissory notes issued carries a provision for an increase in the conversion rate under certain circumstances, which could also potentially increase the dilutive shares outstanding.

 

8. Commitments and Contingencies

 

Contingencies

 

The Company has levied indirect taxes on sugarcane-based biodiesel sales that took place several years ago by Amyris Brasil Ltda. (see Note 12, “Divestiture” in Part II, Item 8 of the 2018 Form 10-K/A) to customers in Brazil, based on advice from external legal counsel. In the absence of definitive rulings from the Brazilian tax authorities on the appropriate indirect tax rate to be applied to such product sales, the actual indirect rate to be applied to such sales could differ from the rate the Company levied.

 

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On April 3, 2019, a securities class action complaint was filed against Amyris and our CEO, John G. Melo, and former CFO (and current Chief Business Officer), Kathleen Valiasek, in the U.S. District Court for the Northern District of California. The complaint seeks unspecified damages on behalf of a purported class that would comprise all persons and entities that purchased or otherwise acquired our securities between March 15, 2018 and March 19, 2019. The complaint alleges securities law violations based on statements and omissions made by the Company during such period. Subsequent to the filing of the securities class action complaint described above, on June 21, 2019 and October 1, 2019, respectively, two separate purported shareholder derivative complaints were filed in the U.S. District Court for the Northern District of California (Bonner v. Doerr, et al., Case No. 4:19-cv-03621 and Carlson v. Doerr, et al., Case No. 4:19-cv-06230) based on similar allegations to those made in the securities class action complaint described above. The derivative complaints name Amyris, Inc. as a nominal defendant and name a number of the Company’s current and former officers and directors as additional defendants. The lawsuits seek to recover, on the Company's behalf, unspecified damages purportedly sustained by the Company in connection with allegedly misleading statements and omissions made in connection with the Company’s securities filings. The derivative complaints also seek a series of changes to the Company’s corporate governance policies, restitution to the Company from the individual defendants, and an award of attorneys’ fees. These cases are in the initial pleadings stage. We believe the complaints lack merit, and intend to defend ourselves vigorously. Given the early stage of these proceedings, it is not yet possible to reliably determine any potential liability that could result from these matters.

 

The Company is subject to disputes and claims that arise or have arisen in the ordinary course of business and that have not resulted in legal proceedings or have not been fully adjudicated. Such matters that may arise in the ordinary course of business are subject to many uncertainties and outcomes are not predictable with reasonable assurance and therefore an estimate of all the reasonably possible losses cannot be determined at this time. Therefore, if one or more of these legal disputes or claims resulted in settlements or legal proceedings that were resolved against the Company for amounts in excess of management's expectations, the Company's consolidated financial statements for the relevant reporting period could be materially adversely affected.

 

Other Matters

 

Certain conditions may exist as of the date the condensed consolidated financial statements are issued, which may result in a loss to the Company but will only be recorded when one or more future events occur or fail to occur. The Company's management assesses such contingent liabilities, and such assessment inherently involves an exercise of judgement. In assessing loss contingencies related to legal proceedings that are pending against and by the Company or unasserted claims that may result in such proceedings, the Company's management evaluates the perceived merits of any legal proceedings or unasserted claims as well as the perceived merits of the amount of relief sought or expected to be sought.

 

If the assessment of a contingency indicates that it is probable that a material loss has been incurred and the amount of the liability can be estimated, then the estimated liability would be accrued in the Company's financial statements. If the assessment indicates that a potential material loss contingency is not probable but is reasonably possible, or is probable but cannot be reasonably estimated, then the nature of the contingent liability, together with an estimate of the range of possible loss if determinable and material would be disclosed. Loss contingencies considered to be remote by management are generally not disclosed unless they involve guarantees, in which case the guarantee would be disclosed.

 

9. Revenue Recognition and Contract Assets and Liabilities

 

Disaggregation of Revenue

 

The following table presents revenue by major product and service, as well as by primary geographical market, based on the location of the customer:

 

   Three Months Ended March 31,
(In thousands)  2019  2018
   Renewable Products  Licenses and Royalties  Grants and Collaborations  Total  Renewable Products  Licenses and Royalties  Grants and Collaborations  Total
United States  $7,073   $   $493   $7,566   $1,962   $   $1,209   $3,171 
Europe   2,854    118    1,629    4,601    2,434    7,955    3,500    13,889 
Asia   1,718        250    1,968    678            678 
South America   220            220    21            21 
Other   19            19    100            100 
   $11,884   $118   $2,372   $14,374   $5,195   $7,955   $4,709   $17,859 

 

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Significant Revenue Agreements During the Three Months Ended March 31, 2019

 

In connection with significant revenue agreements, the Company recognized the following revenues for the three months ended March 31, 2019 and 2018: 

 

   Three Months Ended March 31,
(In thousands)  2019  2018
   Renewable Products  Licenses and Royalties  Grants and Collaborations  Total  Renewable Products  Licenses and Royalties  Grants and Collaborations  Total
Firmenich  $1,891   $498   $728   $3,117   $207   $37   $1,267   $1,511 
Givaudan   1,575            1,575    1,076        1,500    2,576 
American Sugar Refining   1,494            1,494                 
DSM - related party   2    (380)   396    18        7,918    734    8,652 
Subtotal revenue from significant revenue agreements   4,962    118    1,124    6,204    1,283    7,955    3,501    12,739 
Revenue from all other customers   6,922        1,248    8,170    3,912        1,208    5,120 
Total revenue from all customers  $11,884   $118   $2,372   $14,374   $5,195   $7,955   $4,709   $17,859 

 

Contract Assets and Liabilities

 

When a contract results in revenue being recognized in excess of the amount the Company has invoiced or has the right to invoice to the customer, a contract asset is recognized. Contract assets are transferred to accounts receivable, net when the rights to the consideration become unconditional.

 

Contract liabilities consist of payments received from customers, or such consideration that is contractually due, in advance of providing the product or performing services such that control has not passed to the customer.

 

Trade receivables related to revenue from contracts with customers are included in accounts receivable on the condensed consolidated balance sheets, net of the allowance for doubtful accounts. Trade accounts receivable are recorded at the point of renewable product sale or in accordance with the contractual payment terms for licenses and royalties, and grants and collaborative research and development services for the amount payable by the customer to the Company for sale of goods or the performance of services.

 

Contract Balances

 

The following table provides information about accounts receivable and contract liabilities from contracts with customers:

 

(In thousands)  March 31, 2019  December 31, 2018
Accounts receivable, net  $10,968   $16,003 
Accounts receivable - related party, net  $1,334   $1,349 
Accounts receivable, unbilled - related party  $   $8,021 
Accounts receivable, unbilled, noncurrent - related party  $1,203   $1,203 
Contract liabilities  $8,333   $8,236 
Contract liabilities, noncurrent(1)  $1,449   $1,587 

 

(1)     As of March 31, 2019 and December 31, 2018, contract liabilities, noncurrent is presented in Other Noncurrent Liabilities in the condensed consolidated balance sheets because of its insignificance.

 

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Unbilled receivables at the end of the period relate to the Company’s right to consideration from DSM for performance fees. The Company’s right to cash receipt for these minimum royalty amounts occurs on or before December 31, 2019. From December 31, 2018 to March 31, 2019, the combination of current and noncurrent unbilled receivables decreased by $8.0 million as the result of invoices issued to DSM during the period. An $8.0 million unbilled accounts receivable was originally due on December 31, 2019 but was paid early by DSM. The $0.6 million difference between the original amount due and the $7.4 million cash payment received was recorded as a $0.4 million reduction of licenses and royalties revenue during the quarter and a $0.2 million reduction to interest income.

 

Remaining Performance Obligations

 

The following table provides information regarding the estimated revenue expected to be recognized in the future related to performance obligations that are unsatisfied (or partially unsatisfied) based on the Company's existing agreements with customers as of March 31, 2019.

 

(In thousands)  As of March 31, 2019
Remaining 2019  $23,920 
2020   38,508 
2021   31,172 
2022 and thereafter    
Total from all customers  $93,600 

 

In accordance with the disclosure provisions of ASC 606, the table above excludes estimated future revenues for performance obligations that are part of a contract that has an original expected duration of one year or less or a performance obligation with variable consideration that is recognized using the sales-based royalty exception for licenses of intellectual property. Additionally, approximately $17.6 million of estimated future revenue is excluded from the table above, as that amount represents constrained variable consideration.

 

10. Related Party Transactions

 

Related Party Debt

 

See Note 4, "Debt" above for related party debt as of March 31, 2019 and December 31, 2018.

 

Related Party Accounts Receivable and Unbilled Receivables

 

Related party accounts receivable and unbilled receivables as of March 31, 2019 and December 31, 2018 were as follows:

 

(In thousands)  March 31, 2019  December 31, 2018
Accounts receivable:          
DSM  $1,334   $1,071 
Novvi       188 
Total       90 
   $1,334   $1,349 
Accounts receivable, unbilled, current:          
DSM  $   $8,021 
Accounts receivable, unbilled, noncurrent:          
DSM  $1,203   $1,203 

 

Related Party Joint Ventures

 

The Company holds a 50% interest in the Aprinnova joint venture for business-to-business sales of cosmetic ingredients. This joint venture is consolidated in the accompanying condensed consolidated financial statements.

 

25

11. Stock-based Compensation

 

The Company’s stock option activity and related information for the three months ended March 31, 2019 was as follows:

 

   Quantity of Stock Options  Weighted-
average
Exercise
Price
  Weighted-average
Remaining
Contractual
Life, in Years
  Aggregate
Intrinsic
Value, in Thousands
Outstanding - December 31, 2018   5,390,270   $11.55    8.5   $29 
Granted   104,452   $4.73           
Exercised   (3,612)  $3.68           
Forfeited or expired   (63,726)  $14.27           
Outstanding - March 31, 2019   5,427,384   $11.39    8.3   $ 
Vested or expected to vest after March 31, 2019   4,874,155   $12.10    8.3   $ 
Exercisable at March 31, 2019   977,466   $39.20    5.8   $ 

 

The Company’s restricted stock units (RSUs) activity and related information for the three months ended March 31, 2019 was as follows:

 

   Quantity of Restricted Stock Units  Weighted-average Grant-date Fair Value  Weighted-average Remaining Contractual Life, in Years
Outstanding - December 31, 2018   5,294,803   $5.50    1.7 
Awarded   493,790   $4.65      
RSUs released   (192,795)  $6.55      
RSUs forfeited   (102,219)  $5.61      
Outstanding - March 31, 2019   5,493,579   $5.38    1.5 
Vested or expected to vest after March 31, 2019   5,153,107   $5.39    1.5 

 

Stock-based compensation expense related to employee and non-employee options, RSUs and ESPP during the three months ended March 31, 2019 and 2018 was allocated to research and development expense and sales, general and administrative expense as follows:

 

   Three Months Ended March 31,
(In thousands)  2019  2018
Research and development  $663   $363 
Sales, general and administrative   2,789    915 
Total stock-based compensation expense  $3,452   $1,278 

 

As of March 31, 2019, there was unrecognized compensation expense of $31.1 million related to stock options and RSUs. The Company expects to recognize this expense over a weighted-average period of 3.0 years.

 

Evergreen Shares for 2010 Equity Incentive Plan and 2010 Employee Stock Purchase Plan

 

In February 2019, the Company's Board of Directors (the Board) approved increases to the number of shares available for issuance under the Company's 2010 Equity Incentive Plan (the Equity Plan) and 2010 Employee Stock Purchase Plan (the Purchase Plan). These shares in connection with the Equity Plan represented an automatic annual increase in the number of shares available for grant and issuance under the Equity Plan of 3,828,241 shares. This increase is equal to approximately 5.0% of the 76,564,829 total outstanding shares of the Company’s common stock as of December 31, 2018. This automatic increase was effective as of January 1, 2019. These shares in connection with the Purchase Plan represented an automatic annual increase in the number of shares reserved for issuance under the Purchase Plan of 383,824 shares. This increase is equal to approximately 0.5% of the 76,564,829 total outstanding shares of the Company’s common stock as of December 31, 2018. This automatic increase was effective as of January 1, 2019.

 

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12. Subsequent Events

 

Cannabinoid Agreement

 

On May 2, 2019, the Company consummated an agreement entered into March 18, 2019 related to a $300 million research, collaboration and license agreement (the Cannabinoid Agreement) with LAVVAN, Inc., a newly formed investment-backed company (Lavvan), for the development, manufacture and commercialization of cannabinoids, subject to certain closing conditions noted below. Under the agreement, the Company would perform research and development activities and Lavvan would be responsible for the commercialization of the cannabinoids developed under the agreement. The Cannabinoid Agreement is being principally funded on a milestone basis, with the Company also entitled to receive certain supplementary research and development funding from Lavvan. The Company could receive aggregate funding of up to $300 million over the term of the Cannabinoid Agreement if all of the milestones are achieved. Additionally, the agreement provides for profit share to the Company on Lavvan's gross profit margin once products are commercialized; these payments will be due for the next 20 years. The consummation of the transactions contemplated by the Cannabinoid Agreement is subject to certain conditions, including obtaining certain third party consents and releases and the repayment or refinancing of the 2014 Rule 144A Convertible Notes and the 2015 Rule 144A Convertible Notes (see Note 4, “Debt”). On May 2, 2019, the parties consummated the transactions contemplated by the Cannabinoid Agreement, including the formation of a special purpose entity to hold certain intellectual property created during the collaboration (the Cannabinoid Collaboration IP), the licensing of certain Company intellectual property to Lavvan, the licensing of the Cannabinoid Collaboration IP to the Company and Lavvan, and the granting by the Company to Lavvan of a lien on the Company background intellectual property being licensed to Lavvan under the Cannabinoid Agreement, which lien would be subordinated to the lien on such intellectual property under the GACP Term Loan Facility (see Note 4, “Debt”).

 

LSA Amendments, Assignment and Waivers

 

On April 4, 2019, the Company and GACP amended the LSA (see Note 4, “Debt”) to (i) effective December 31, 2018, eliminate the conditions giving rise to the early maturity date, so that loans under the GACP Term Loan Facilities would have a maturity date of July 1, 2021, (ii) remove certain Company intellectual property related to the Cannabinoid Agreement from the lien granted by the Company to GACP under the LSA, (iii) eliminate the Company’s ability to obtain the Incremental GACP Term Loan Facility, (iv) eliminate the Company’s reinvestment rights with respect to mandatory prepayments upon asset sales, (v) restrict the Company’s ability to pay interest and principal on other indebtedness without the consent of GACP, and (vi) provide that the Company must have at all times at least $15 million of unrestricted, unencumbered cash subject to a control agreement in favor of GACP.

 

On April 4, 2019, the Company and GACP entered into a waiver agreement, pursuant to which GACP agreed to waive breaches of certain covenants under the LSA occurring prior to, as of and after December 31, 2018 through April 8, 2019, including covenants related to quarterly minimum revenues, minimum liquidity amounts and a minimum asset coverage ratio. In connection with such waiver, the Company agreed to pay GACP fees of $0.8 million.

 

On April 15, 2019, the Company, GACP and Foris Ventures, LLC (Foris, an entity affiliated with director John Doerr of Kleiner Perkins Caufield & Byers, a current stockholder, and an owner of greater than five percent of the Company’s outstanding common stock) entered into a Loan Purchase Agreement, pursuant to which Foris agreed to purchase and assume from GACP, and GACP agreed to sell and assign to Foris, the outstanding loans under the LSA and all documents and assets related thereto. In connection with such purchase and assignment, the Company agreed to repay Foris $2.5 million of the purchase price paid by Foris to GACP (the Company LPA Obligation). The closing of the loan purchase and assignment occurred on April 16, 2019.

 

On August 14, 2019, the Company and Foris entered into an Amendment No. 5 and Waiver to the LSA (the LSA Amendment and Waiver), pursuant to which (i) the maturity date of the loans under the LSA was extended from July 1, 2021 to July 1, 2022, (ii) the interest rate for the loans under the LSA was modified from the sum of (A) the greater of (x) the prime rate as reported in the Wall Street Journal or (y) 4.75% plus (B) 9% to the greater of (A) 12% or (B) the rate of interest payable with respect to any indebtedness of the Company, (iii) the amortization of the loans under the LSA was delayed until December 16, 2019, (iv) certain accrued and future interest and agency fee payments under the LSA were delayed until December 16, 2019, (v) certain covenants under the LSA, including related definitions, were amended to provide the Company with greater operational and financial flexibility, including, without limitation, to permit the incurrence of the indebtedness under the Naxyris Loan Facility (as described below) and the granting of liens with respect thereto, subject to the terms of an intercreditor agreement between Foris and Naxyris S.A. (Naxyris) governing the respective rights of the parties with respect to, among other things, the assets securing the Naxyris Loan Agreement and the LSA (the Intercreditor Agreement), (vi) certain outstanding unsecured promissory notes issued by the Company to Foris on April 8, 2019, June 11, 2019, July 10, 2019 and July 26, 2019 (as described below under “Foris Credit Agreements”), in an aggregate principal amount of $32.5 million, as well as the Company LPA Obligation, were added to the loans under the LSA, made subject to the LSA and secured by the security interest in the collateral granted to Foris under the LSA, and such promissory notes and contractual obligation were canceled in connection therewith, and (vii) Foris agreed to waive certain existing defaults under the LSA. After giving effect to the LSA Amendment and Waiver, there is $71.0 million aggregate principal amount of loans outstanding under the LSA, subject to quarterly covenants including minimum revenues, minimum liquidity amounts and a minimum asset coverage ratio. In connection with the entry into the LSA Amendment and Waiver, on August 14, 2019 the Company issued to Foris a warrant to purchase up to 1,438,829 shares of Common Stock at an exercise price of $2.87 per share, with an exercise term of two years from issuance. Pursuant to the terms of the warrant, Foris may not exercise the Foris Warrant to the extent that, after giving effect to such exercise, Foris, together with its affiliates, would beneficially own in excess of 19.99% of the number of shares of common stock outstanding after giving effect to such exercise, unless the Company has obtained stockholder approval to exceed such limit in accordance with Nasdaq rules and regulations, which the Company intends to seek at its 2019 annual meeting of stockholders.

 

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Foris Credit Agreements

 

On April 8, 2019, the Company and Foris entered into a credit agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of $8.0 million (the April Foris Credit Agreement), which the Company borrowed in full on April 8, 2019 and issued to Foris a promissory note in the principal amount of $8.0 million (the April Foris Note). The April Foris Note has a maturity date of October 14, 2019. In connection with the entry into the April Foris Credit Agreement and the issuance of the April Foris Note, which has no stated interest rate, the Company agreed to pay Foris a fee of $1.0 million, payable on or prior to the maturity date of the April Foris Note (the April Foris Note Fee); provided, that the April Foris Note Fee will be reduced to $0.5 million if the Company repays the April Foris Note in full by July 15, 2019. The April Foris Note is subordinated in right of payment to the Tranche II Note held by Wolverine (see Note 4, “Debt” and above in this Note 12, “Subsequent Events”).

 

On June 11, 2019, the Company and Foris entered into a credit agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of $8.5 million, which the Company borrowed in full on June 11, 2019 and issued to Foris a promissory note in the principal amount of $8.5 million (the June Foris Note). The June Foris Note (i) accrues interest at a rate of 12.5% per annum from and including June 11, 2019, which interest is payable on the maturity date or the earlier repayment or other satisfaction of the June Foris Note, and (ii) matures on August 28, 2019; provided, that if the May 2017 Cash Warrant held by DSM and the August 2017 DSM Cash Warrant (see Note 6, “Stockholders’ Deficit”) are exercised, then the maturity date of the June Foris Note will be the business day immediately following such exercise.

 

On July 10, 2019, the Company and Foris entered into a credit agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of $16.0 million (the July Foris Credit Agreement), of which the Company borrowed $8.0 million on July 10, 2019 and $8.0 million on July 26, 2019 and issued to Foris promissory notes, each in the principal amount of $8.0 million, on such dates (the July Foris Notes). The July Foris Notes (i) accrue interest at a rate of 12.5% per annum from and including the respective date of issuance, which interest is payable on the maturity date or the earlier repayment or other satisfaction of the applicable July Foris Note, and (ii) mature on December 31, 2019. In connection with the entry into the July Foris Credit Agreement, the Company and Foris amended the warrant issued to Foris on August 17, 2018 (see Note 6, “Stockholders’ Deficit”) to reduce the exercise price of such warrant from $7.52 per share to $2.87 per share.

 

The Company may at its option repay the amounts outstanding under the April Foris Note (including the April Foris Note Fee), the June Foris Note and the July Foris Notes before their respective maturity dates, in whole or in part, at a price equal to 100% of the amount being repaid plus, in the case of the June Foris Note and the July Foris Notes, accrued and unpaid interest on such amount to the date of repayment.

 

On August 14, 2019, the April Foris Note, the June Foris Note and the July Foris Notes were added to the loans under the LSA, made subject to the LSA and secured by the security interest in the collateral granted to Foris under the LSA, and such notes were canceled in connection therewith. See above under “LSA Amendments, Assignment and Waivers” for additional information.

 

On August 28, 2019, the Company and Foris entered into a credit agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of $19.0 million (the August Foris Credit Agreement), which the Company borrowed in full on August 28, 2019 and issued to Foris a promissory note in the principal amount of $19.0 million (the August Foris Note). The August Foris Note (i) accrues interest at a rate of 12% per annum from and including August 28, 2019, which interest is payable quarterly in arrears on each March 31, June 30, September 30 and December 31, beginning December 31, 2019, and (ii) matures on January 1, 2023. The Company may at its option repay the amounts outstanding under the August Foris Note before the maturity date, in whole or in part, at a price equal to 100% of the amount being repaid plus accrued and unpaid interest on such amount to the date of repayment. Also, on August 28, 2019 in connection with the entry into the August Foris Credit Agreement, the Company and Foris amended the warrant issued to Foris on April 26, 2019 to reduce the exercise price of such warrant from $5.12 per share to $3.90 per share, and amended the warrant issued to Foris on May 14, 2019 to reduce the exercise price of such warrant from $4.56 per share to $3.90 per share. See Note 6, “Stockholders’ Deficit” for information on the original warrants.

 

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In connection with the entry into the August Foris Credit Agreement, on August 14, 2019 the Company issued to Foris a warrant to purchase up to 4,871,795 shares of Common Stock at an exercise price of $3.90 per share, with an exercise term of two years from issuance in a private placement pursuant to the exemption from registration under Section 4(a)(2) of the Securities Act of 1933, as amended (the Securities Act), and Regulation D promulgated under the Securities Act. The exercise price of the warrant is subject to standard adjustments but does not contain any anti-dilution protection, and the warrants only permit “cashless” or “net” exercise after the six-month anniversary of issuance of the applicable warrant, and only to the extent that there is not an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, Foris may not exercise the warrant to the extent that, after giving effect to such exercise, Foris, together with its affiliates, would beneficially own in excess of 19.99% of the number of shares of common stock outstanding after giving effect to such exercise, unless the Company has obtained stockholder approval to exceed such limit in accordance with Nasdaq rules and regulations, which the Company intends to seek at its 2019 annual meeting of stockholders.

 

Private Placements

 

On April 16, 2019, the Company sold and issued to Foris 6,732,369 shares of common stock at a price of $2.87 per share, as well as a warrant to purchase up to 5,424,804 shares of common stock at an exercise price of $2.87 per share, with an exercise term of two years from issuance, in a private placement pursuant to the exemption from registration under Section 4(a)(2) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of $20.0 million (the Foris Investment).

 

On April 26, 2019, the Company sold and issued (i) 2,832,440 shares of common stock at a price of $5.12 per share, as well as a warrant to purchase up to 3,983,230 shares of common stock at an exercise price of $5.12 per share, with an exercise term of two years from issuance, to Foris and (ii) an aggregate of 2,043,781 shares of common stock at a price of $4.02 per share, as well as warrants to purchase up to an aggregate of 1,635,025 shares of common stock at an exercise price of $5.02 per share, with an exercise term of two years from issuance, to certain other non-affiliated investors, in each case in private placements pursuant to the exemption from registration under Section 4(a)(2) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of $23.2 million. On August 28, 2019, in connection with the entry into the August Foris Credit Agreement (as described above under "Foris Credit Agreements"), the Company and Foris amended the warrant issued to Foris on April 26, 2019 to reduce the exercise price of such warrant from $5.12 per share to $3.90 per share.

 

On April 29, 2019, the Company sold and issued (i) 913,529 shares of common stock at a price of $4.76 per share, as well as a warrant to purchase up to 1,212,787 shares of common stock at an exercise price of $4.76 per share, with an exercise term of two years from issuance, to Vivo and (ii) an aggregate of 323,382 shares of common stock at a price of $4.02 per share, as well as warrants to purchase up to an aggregate of 258,704 shares of common stock at an exercise price of $5.02 per share, with an exercise term of two years from issuance, to certain other non-affiliated investors, in each case in private placements pursuant to the exemption from registration under Section 4(a)(2) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of $5.8 million.

 

On May 3, 2019, the Company sold and issued 1,243,781 shares of common stock at a price of $4.02 per share, as well as a warrant to purchase up to 995,024 shares of common stock at an exercise price of $5.02 per share, with an exercise term of two years from issuance, to a non-affiliated investor in a private placement pursuant to the exemption from registration under Section 4(a)(2) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of $5 million.

 

The exercise price of the warrants issued in the foregoing private placements is subject to standard adjustments but does not contain any anti-dilution protection, and the warrants only permit “cashless” or “net” exercise after the six-month anniversary of issuance of the applicable warrant, and only to the extent that there is not an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, in connection with the foregoing private placements, the Company agreed not to effect any exercise or conversion of any Company security, and the investors agreed not to exercise or convert any portion of any Company security, to the extent that after giving effect to such exercise or conversion, the applicable investor, together with its affiliates, would beneficially own in excess of 19.99% of the number of shares of common stock outstanding immediately after giving effect to such exercise or conversion, and the warrant contained a similar limitation.

 

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DSM Agreements

 

On April 16, 2019, the Company assigned to DSM, and DSM assumed, all of the Company’s rights and obligations under the Value Sharing Agreement (see Note 9, “Revenue Recognition”), for aggregate consideration to the Company of $57.0 million, $29.1 million of which was paid to the Company in cash, with the remaining $27.9 million being used to pay certain existing obligations of the Company to DSM. The Company used a majority of the cash proceeds to repay a portion of the 2015 Rule 144A Convertible Notes (see Note 4, “Debt”).

 

In addition, on April 16, 2019 the Company and DSM entered into amendments to the Supply Agreement and the Performance Agreement (see Note 9, “Revenue Recognition”), as well as the Quota Purchase Agreement relating to the December 2017 sale of Amyris Brasil to DSM (see Note 13, “Divestiture” in Part II, Item 8 of the 2018 Form 10-K/A), pursuant to which (i) DSM agreed to reduce certain manufacturing costs and fees paid by the Company related to the production of farnesene under the Supply Agreement through 2021, as well as remove the priority of certain customers over the Company with respect to production capacity at the Brotas, Brazil facility, (ii) the Company agreed to provide DSM rights to conduct certain process and downstream recovery improvements under the Performance Agreement at facilities other than the Brotas, Brazil facility in exchange for DSM providing the Company with a license to such improvements and (iii) the Company released DSM from its obligation to provide manufacturing and support services under the Quota Purchase Agreement in connection with the Company’s planned new manufacturing facility, which is no longer planned to be located at the Brotas, Brazil location.

 

On September 17, 2019, the Company and DSM entered into a credit agreement (the “2019 DSM Credit Agreement”) to make available to the Company a secured credit facility in an aggregate principal amount of $8.0 million, to be issued in separate installments of $3.0 million, $3.0 million and $2.0 million, respectively, with each installment being subject to certain closing conditions, including the payment of certain existing obligations of the Company to DSM. On September 17, 2019, the Company borrowed the first installment of $3.0 million under the 2019 DSM Credit Agreement, all of which proceeds were used to pay certain existing obligations of the Company to DSM, and issued to DSM a promissory note in the principal amount of $3.0 million. On September 19, 2019, the Company borrowed the second installment of $3.0 million under the 2019 DSM Credit Agreement, all of which proceeds were used to pay certain existing obligations of the Company to DSM, and issued to DSM a promissory note in the principal amount of $3.0 million. On September 23, 2019, the Company borrowed the final installment of $2.0 million under the 2019 DSM Credit Agreement, $1.5 million of which proceeds were used to pay certain existing obligations of the Company to DSM, and issued to DSM a promissory note in the principal amount of $2.0 million. The promissory notes issued under the 2019 DSM Credit Agreement (i) mature on August 7, 2022, (ii) accrue interest at a rate of 12.5% per annum from and including the applicable date of issuance, which interest is payable quarterly in arrears on each January 1, April 1, July 1 and October 1, beginning January 1, 2020, and (iii) are secured by a first-priority lien on certain Company intellectual property licensed to DSM. The Company may at its option repay the amounts outstanding under the 2019 DSM Credit Agreement before the maturity date, in whole or in part, at a price equal to 100% of the amount being repaid plus accrued and unpaid interest on such amount to the date of repayment. In addition, the Company is required to repay the amounts outstanding under the 2019 DSM Credit Agreement (i) in an amount equal to the gross cash proceeds, if any, received by the Company upon the exercise by DSM of any of the common stock purchase warrants issued by the Company to DSM on May 11, 2017 or August 7, 2017 (see Note 7, “Stockholders’ Deficit”) and (ii) in full upon the request of DSM at any time following the receipt by the Company of at least $50.0 million of gross cash proceeds from one or more sales of equity securities of the Company on or prior to June 30, 2020.

 

Raizen Joint Venture Agreement

 

On May 10, 2019, the Company and Raizen Energia S.A. (Raizen) entered into a joint venture agreement relating to the formation and operation of a joint venture relating to the production, sale and commercialization of alternative sweetener products. In connection with the formation of the joint venture, among other things, (i) the joint venture will construct a manufacturing facility on land owned by Raizen and leased to the joint venture (the Sweetener Plant), (ii) the Company will grant to the joint venture an exclusive, royalty-free, worldwide, license to certain technology owned by the Company relevant to the joint venture’s business, and (iii) the Company and Raizen will enter into a shareholders agreement setting forth the rights and obligations of the parties with respect to, and the management of, the joint venture. The formation of the joint venture is subject to certain conditions, including certain regulatory approvals and the achievement of certain technological and economic milestones relating to the Company’s existing production of its alternative sweetener product. If such conditions are not satisfied by December 31, 2019, the joint venture will automatically terminate. In addition, notwithstanding the satisfaction of the closing conditions, Raizen may elect not to consummate the formation and operation of the joint venture, in which event, the Company will retain the right to construct and operate the Sweetener Plant.

 

Upon the closing of the joint venture, each party will make an initial capital contribution to the joint venture of 2,500,000 Brazilian Real (R$2,500,000) and the joint venture will be owned 50% by the Company and 50% by Raizen. Within 60 days of the formation, the parties will make an aggregate cash contribution to the joint venture of U.S.$9,000,000 to purchase certain fixed assets currently owned by the Company and located at the site of the Company’s former joint venture with Sao Martinho S.A. in Pradopolis, Brazil for U.S.$3,000,000. In addition, within six months of the formation, the Company will contribute to the joint venture its existing supply agreements related to its alternative sweetener product, subject to certain exceptions, in exchange for shares of dividend-bearing preferred stock in the joint venture, which will be entitled, for a period of 10 years commencing from the initial date of operation of the Sweetener Plant, to certain priority fixed cumulative dividends including, in the event that certain technological and economic milestones are met in any fiscal quarter, a percentage of the operating cash flow of the joint venture in such quarter.

 

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After the formation of the joint venture, the parties will not conduct activities similar or identical to the joint venture. In the event that certain technological and economic milestones are not met in any fiscal year beginning with the third fiscal year after formation of the joint venture and ending with the seventh fiscal year after formation of the joint venture, Raizen shall have the right to sell all of its shares in the joint venture to the Company at a price per share equal to the higher of the book value and the amount of Raizen’s investments in the joint venture, as adjusted for Raizen’s cost of capital.

 

2015 and 2014 Rule 144A Convertible Notes Exchanges

 

On April 16, 2019, the Company repaid in cash the $37.9 million outstanding balance under the 2015 Rule 144A Convertible Notes.

 

On May 10, 2019, the Company exchanged $13.5 million aggregate principal amount of the 2014 Rule 144A Convertible Notes (see Note 4, “Debt”) held by certain non-affiliated investors, including accrued and unpaid interest thereon up to, but excluding, May 15, 2019, for an aggregate of 3,479,008 shares of common stock and warrants to purchase an aggregate of 1,391,603 shares of common stock at an exercise price of $5.02 per share, with an exercise term of two years from issuance, in a private exchange pursuant to the exemption from registration under Section 3(a)(9) of the Securities Act.

 

On May 14, 2019, the Company exchanged $5.0 million aggregate principal amount of the 2014 Rule 144A Convertible Notes held by Foris, including accrued and unpaid interest thereon up to, but excluding, May 15, 2019, for 1,122,460 shares of common stock and a warrant to purchase up to 352,638 shares of common stock at an exercise price of $4.56 per share, with an exercise term of two years from issuance, in a private exchange pursuant to the exemption from registration under Section 3(a)(9) of the Securities Act. On August 28, 2019, in connection with the entry into the August Foris Credit Agreement (as described above under "Foris Credit Agreements"), the Company and Foris amended the warrant issued to Foris on May 14, 2019 to reduce the exercise price of such warrant from $4.56 per share to $3.90 per share.

 

On May 15, 2019, the Company exchanged $10.0 million aggregate principal amount of the 2014 Rule 144A Convertible Notes held by Maxwell (Mauritius) Pte Ltd for 2,500,000 shares of common stock in a private exchange pursuant to the exemption from registration under Section 3(a)(9) of the Securities Act.

 

On May 15, 2019, the Company exchanged $9.7 million aggregate principal amount of the 2014 Rule 144A Convertible Notes held by Total for a new senior convertible note with an equal principal amount and with substantially identical terms, except that the new note had a maturity date of June 14, 2019, in a private exchange pursuant to the exemption from registration under Section 3(a)(9) of the Securities Act. Effective June 14, 2019, the Company and Total agreed to extend the maturity date of the new note from June 14, 2019 to July 18, 2019. Effective July 18, 2019, the Company and Total agreed to (i) further extend the maturity date of the new note from July 18, 2019 to August 28, 2019 and (ii) increase the interest rate on the new note to 10.50% per annum, beginning July 18, 2019.

 

The exercise price of the warrants issued in the foregoing exchanges is subject to standard adjustments but does not contain any anti-dilution protection, and the warrants only permit “cashless” or “net” exercise after the six-month anniversary of the exercisability of the applicable warrant, and only to the extent that there is not an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, (i) the exercisability of the warrant issued to Foris is subject to stockholder approval in accordance with Nasdaq rules and regulations, which the Company intends to seek at its 2019 annual meeting of stockholders, and (ii) each warrant provides that the Company may not effect any exercise of such warrant to the extent that, after giving effect to such exercise, the applicable holder, together with its affiliates, would beneficially own in excess of 4.99% of the number of shares of common stock outstanding after giving effect to such exercise.

 

6% Convertible Notes due 2021 Exchanges

 

On May 15, 2019 and June 24, 2019, the Company exchanged $53.3 million and $4.7 million principal amount, respectively, of the 6% Convertible Notes due 2021 (see Note 4, “Debt”), including accrued and unpaid interest thereon, representing all then-outstanding 6% Convertible Notes due 2021, for new senior convertible notes with an equal principal amount and warrants to purchase up to 2,000,000 and 181,818 shares of common stock, respectively, at an exercise price of $5.12 per share, with an exercise term of two years from issuance, in private exchanges pursuant to the exemption from registration under Section 3(a)(9) of the Securities Act. The new notes have substantially identical terms as the 6% Convertible Notes due 2021 being exchanged, except that (i) the holders agreed to waive, until July 22, 2019, certain covenants relating to the effectiveness of the registration statement covering the shares of common stock issuable upon conversion of, or otherwise pursuant to, the new notes and the filing by the Company of reports with the SEC and (ii) during the period from July 22, 2019 to July 29, 2019, inclusive, the holders have the right to require the Company to redeem the new notes, in whole or in part, at a price equal to 125% of the principal amount being redeemed. The exercise price of the warrants is subject to standard adjustments but does not contain any anti-dilution protection, and the warrants only permit “cashless” or “net” exercise after the six-month anniversary of issuance, and only to the extent that there is not an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, the holders may not exercise the warrants, and the Company may not affect any exercise of the warrants, to the extent that, after giving effect to such exercise, the applicable holder, together with its affiliates, would beneficially own in excess of 4.99% of the number of shares of common stock outstanding after giving effect to such exercise.

 

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On July 24, 2019, Company further exchanged $53.3 million principal amount of the previously-exchanged 6% Convertible Senior Notes due 2021 as well as the warrant to purchase up to 2,000,000 shares of common stock issued on May 15, 2019, for a new senior convertible note with a principal amount of $68.3 million (the Second Exchange Note) and a new warrant to purchase up to 2,000,000 shares of common stock at an exercise price of $2.87 per share, with an exercise term of two years from May 15, 2019 (the Second Exchange Warrant) in a private exchange pursuant to the exemption from registration under Section 3(a)(9) of the Securities Act. The Second Exchange Note and Second Exchange Warrant have substantially similar terms as the note and warrant, respectively, issued on May 15, 2019, except that (i) the principal amount of the Second Exchange Note would be $68.3 million, reflecting accrued and unpaid interest and late charges under the exchanged note and a 25% premium accruing as a result of the Company’s failure to make an installment payment on the exchanged note due July 1, 2019 in the amount of $6.4 million, provided that upon an event of default under the Second Exchange Note, the Company would not be required to redeem the Second Exchange Note in cash at a price greater than the intrinsic value of the shares of common stock underlying the Second Exchange Note, (ii) the Second Exchange Note bears interest at a rate of 18% per annum, (iii) the holder agreed to extend its waiver of certain covenant breaches relating to the failure by the Company to timely file periodic reports with the SEC from July 22, 2019 to September 16, 2019, (iv) the first installment date under the Second Exchange Note will occur on October 1, 2019, (v) the Company is required to (A) make principal payments on the Second Exchange Note in the amount of $3.2 million on each of August 2, 2019 and August 22, 2019, and (B) pay all remaining amounts then outstanding under the Second Exchange Note on September 16, 2019, and if the Company fails to make any such payment on the applicable payment date, the conversion price of the Second Exchange Note will be reset to the volume-weighted average price of the common stock on the trading day immediately following the Company’s filing of a Current Report on Form 8-K with respect to its failure to make the payment due on September 16, 2019, if such volume-weighted average price is lower than the conversion price of the Second Exchange Note then in effect, subject to a price floor and (vi) the Second Exchange Warrant has an exercise price of $2.87 per share.

 

On July 26, 2019, one of the holders of the senior convertibles notes issued in exchange for the 6% Convertible Notes due 2021, holding a senior convertible note in the principal amount of $4.7 million issued on June 24, 2019, exercised its right to require the Company to redeem such note in whole at a price equal to 125% of the principal amount being redeemed, plus accrued and unpaid interest on such note to the date of repayment. Redemption of such note was initially due on July 30, 2019 and subsequently extended to August 30, 2019. The Company redeemed such note in full on August 30, 2019.

 

On September 16, 2019, the Company failed to pay an aggregate of $63.6 million of outstanding principal and accrued interest on the Second Exchange Note when due. The failure resulted in an event of default under the Second Exchange Note and also triggered cross-defaults under other debt instruments of the Company which permitted the holders of such indebtedness to accelerate the amounts owing under such instruments. The Company subsequently received waivers from substantially all holders of such other debt instruments to waive the right to accelerate. As a result, the indebtedness with respect to which the Company has obtained such waivers continues to be classified as long-term on the Company’s balance sheet.  The indebtedness reflected by the Second Exchange Note continues to be classified as a current liability on the Company’s balance sheet. In addition, as a result of the payment default, the conversion price of the Second Exchange Note is subject to adjustment in accordance with the terms of the Second Exchange Note.

 

The Company does not currently have sufficient funds to repay the amounts outstanding under the Second Exchange Note. To date, negotiations with the holder of the Second Exchange Note have not been successful, and there can be no assurance that a favorable outcome for the Company will be reached. The Company has executed a term sheet with an existing investor for a term loan, the proceeds of which would be used to repay a portion of the Second Exchange Note. However, there can be no assurance that the Company will be able to obtain such financing on its expected timeline, or on acceptable terms, if at all. Even if the Company does obtain such financing, it will not have sufficient funds to repay the Second Exchange Note in full without obtaining additional financing, which the Company is attempting to source. The condensed consolidated financial statements do not include any adjustments that might result from the outcome of this uncertainty.

 

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Exchange of August 2013 Financing Convertible Note

 

On July 8, 2019, the August 2013 Financing Convertible Note held by Wolverine (see Note 4, “Debt”) was exchanged for 1,767,632 shares of common stock and a warrant to purchase 1,080,000 shares of common stock in a private exchange pursuant to the exemption from registration under Section 3(a)(9) of the Securities Act. The exercise price of the warrant is subject to standard adjustments but does not contain any anti-dilution protection, and the warrant only permits “cashless” or “net” exercise after the six-month anniversary of issuance, and only to the extent that there is not an effective registration statement covering the resale of the shares of common stock underlying the warrant. In addition, Wolverine may not exercise the warrant to the extent that, after giving effect to such exercise, Wolverine, together with its affiliates, would beneficially own in excess of 4.99% of the number of shares of common stock outstanding after giving effect to such exercise.

 

Nikko Loan Agreement

 

On July 29, 2019, the Company and Nikko Chemicals Co., Ltd. (Nikko) entered into a loan agreement (the Nikko Loan Agreement) to make available to the Company secured loans in an aggregate principal amount of $5.0 million, to be issued in separate installments of $3.0 million and $2.0 million, respectively, with each installment being subject to certain closing conditions, including the entry into certain commercial agreements and other arrangements relating to the Aprinnova JV (see Note 10, “Related Party Transactions”). On July 30, 2019, the Company borrowed the first installment of $3.0 million under the Nikko Loan Agreement and received net cash proceeds of $2.8 million, with the remaining $0.2 million being withheld by Nikko as prepayment of the interest payable on such loan through the maturity date. On August 8, 2019, the Company borrowed the remaining $2.0 million available under the Nikko Loan Agreement and received net cash proceeds of $1.9 million, with the remaining $0.1 million being withheld by Nikko as prepayment of the interest payable on such loan through the maturity date. The loans (i) mature on December 18, 2020, (ii) accrue interest at a rate of 5% per annum from and including the applicable loan date through the maturity date, which interest is required to be prepaid in full on the date of the applicable loan, and (iii) are secured by a first-priority lien on 12.8% of the Aprinnova JV interests owned by the Company.

 

Aprinnova Working Capital Loan

 

Effective July 31, 2019, the Company and Nikko agreed to extend the term of the Second Aprinnova Note (see Note 5, “Debt” in the 2018 Form 10-K/A) from August 1, 2019 to August 1, 2020.

 

Naxyris Loan and Security Agreement

 

On August 14, 2019, the Company, certain of the Company’s subsidiaries (the Subsidiary Guarantors) and, as lender, Naxyris, an existing stockholder of the Company and an investment vehicle owned by Naxos Capital Partners SCA Sicar, which is affiliated with NAXOS S.A.R.L. (Switzerland), for which director Carole Piwnica serves as director, entered into a Loan and Security Agreement (the Naxyris Loan Agreement) to make available to the Company a secured term loan facility in an aggregate principal amount of up to $10,435,000 (the Naxyris Loan Facility), which the Company borrowed in full on August 14, 2019.

 

Loans under the Naxyris Loan Facility have a maturity date of July 1, 2022 and accrue interest at a rate per annum equal to the greater of (i) 12% or (ii) the rate of interest payable with respect to any indebtedness of the Company plus 25 basis points, which interest will be payable monthly in arrears, provided that all interest accruing from and after August 14, 2019 through December 1, 2019 shall be due and payable on December 15, 2019.

 

The obligations of the Company under the Naxyris Loan Facility are (i) guaranteed by the Subsidiary Guarantors and (ii) secured by a perfected security interest in substantially all of the assets of the Company and the Subsidiary Guarantors (the Collateral), junior in payment priority to Foris Ventures subject to certain limitations and exceptions, as well as the terms of the Intercreditor Agreement (as defined above).

 

Mandatory prepayments of the outstanding amounts under the Naxyris Loan Facility will be required upon the occurrence of certain events, including asset sales, a change in control, and the incurrence of additional indebtedness, subject to certain exceptions and reinvestment rights. Outstanding amounts under the Naxyris Loan Facility must also be prepaid to the extent that the borrowing base exceeds the outstanding principal amount of the loans under the Naxyris Loan Facility. In addition, the Company may at its option prepay the outstanding principal amount of the loans under the Naxyris Loan Facility in full before the maturity date. Any prepayment of the loans under the Naxyris Loan Facility prior to the maturity date, whether pursuant to a mandatory or optional prepayment, is subject to a prepayment charge equal to one year’s interest at the then-current interest rate for the Naxyris Loan Facility. Upon the repayment of the loans under the Naxyris loan facility, whether on the maturity date or earlier pursuant to an optional or mandatory prepayment, the Company will pay Naxyris an end of term fee. In addition, (i) the Company will be required to pay a fee equal to 6% of any amount the Company fails to pay within three business days of its due date and (ii) any interest that is not paid when due will be added to principal and will bear compound interest at the applicable rate.

 

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The affirmative and negative covenants in the Naxyris Loan Agreement relate to, among other items: (i) payment of taxes; (ii) financial reporting; (iii) maintenance of insurance; and (iv) limitations on indebtedness, liens, mergers, consolidations and acquisitions, transfers of assets, dividends and other distributions in respect of capital stock, investments, loans and advances, and corporate changes. The Naxyris Loan Agreement also contains financial covenants, including covenants related to minimum revenue, liquidity, and asset coverage.

 

September 2019 Credit Agreements

 

On September 10, 2019, the Company entered into separate credit agreements (the “Investor Credit Agreements”) with each of Schottenfeld Opportunities Fund II, L.P., Phase Five Partners, LP and Koyote Trading, LLC (the “Investors”) to make available to the Company unsecured credit facilities in an aggregate principal amount of $12.5 million, which the Company borrowed in full on September 10, 2019 and issued to the Investors separate promissory notes in the aggregate principal amount of $12.5 million (the “Investor Notes”). Each Investor Note (i) accrues interest at a rate of 12% per annum from and including September 10, 2019, which interest is payable quarterly in arrears on each March 31, June 30, September 30 and December 31, beginning December 31, 2019, and (ii) matures on January 1, 2023. The Company may at its option repay the amounts outstanding under the Investor Notes before the maturity date, in whole or in part, at a price equal to 100% of the amount being repaid plus accrued and unpaid interest on such amount to the date of repayment.

 

In connection with the entry into the Investor Credit Agreements, on September 10, 2019, the Company issued to the Investors warrants to purchase up to an aggregate of 3,205,128 shares of Common Stock at an exercise price of $3.90 per share, with an exercise term of two years from issuance in a private placement pursuant to the exemption from registration under Section 4(a)(2) of the Securities Act and Regulation D promulgated under the Securities Act. The exercise price of the warrants is subject to standard adjustments but does not contain any anti-dilution protection, and the warrants only permit “cashless” or “net” exercise after the six-month anniversary of issuance of the applicable warrant, and only to the extent that there is not an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, no Investor may exercise its warrant to the extent that, after giving effect to such exercise, such Investor, together with its affiliates, would beneficially own in excess of 9.99% of the number of shares of common stock outstanding after giving effect to such exercise. In addition, the Company agreed to file a registration statement providing for the resale by the Investors of the shares of Common Stock underlying the warrants with the SEC within 60 days following the date of the issuance of the warrants and to use commercially reasonable efforts to (i) cause such registration statement to become effective within 120 days following the date of the issuance of the warrants and (ii) keep such registration statement effective until the Investors no longer beneficially own any such shares of Common Stock or such shares of Common Stock are eligible for resale under Rule 144 under the Securities Act without regard to volume limitations. If the Company fails to file the registration statement by the filing deadline or the registration statement is not declared effective by the effectiveness deadline, or the Company fails to maintain the effectiveness of the registration statement as required by the warrants, then the exercise price of the warrants will be reduced by 10%, and by an additional 5% if such failure continues for longer than 90 days, subject to an exercise price floor of $3.31 per share, provided that upon the cure by the Company of such failure, the exercise price of the warrants will revert to $3.90 per share.

 

In connection with the entry into the Investor Credit Agreements and the issuance of the warrants, on September 10, 2019, the Company and the Investors entered into a Standstill Agreement (the “Investor Standstill Agreement”), pursuant to which the Investors agreed that, until the earliest to occur of (i) the Investors no longer beneficially owning any shares underlying the warrants, (ii) the Company entering into a definitive agreement involving the direct or indirect acquisition of all or a majority of the Company’s equity securities or all or substantially all of the Company’s assets or (iii) a person or group, with the prior approval of the Company’s Board of Directors (the “Board”), commencing a tender offer for all or a majority of the Company's equity securities, neither the Investors nor any of their respective affiliates will (without the prior written consent of the Board), among other things, (i) acquire any loans, debt securities, equity securities, or assets of the Company or any of its subsidiaries, or rights or options with respect thereto, except that the Investors shall be permitted to (a) purchase the shares underlying the warrants pursuant to the exercise of the warrants and (b) acquire beneficial ownership of up to 6.99% of the Common Stock, or (ii) make any proposal, public announcement, solicitation or offer with respect to, or otherwise solicit, seek or offer to effect, or instigate, encourage, or assist any third party with respect to: (a) any business combination, merger, tender offer, exchange offer, or similar transaction involving the Company or any of its subsidiaries; (b) any restructuring, recapitalization, liquidation, or similar transaction involving the Company or any of its subsidiaries; (c) any acquisition of any of the Company’s loans, debt securities, equity securities or assets, or rights or options with respect thereto; or (d) any proposal to seek representation on the Board or otherwise seek to control or influence the management, Board, or policies of the Company, in each case subject to certain exceptions.

 

Ginkgo Note Amendment

 

On September 29, 2019, in connection with Ginkgo granting certain waivers under the November 2017 Ginkgo Note and the Ginkgo Partnership Agreement (see Note 5, “Debt” and Note 10, "Revenue Recognition" in Part II, Item 8 of the 2018 Form 10-K/A), (i) the Company and Ginkgo amended the November 2017 Ginkgo Note to increase the interest rate from 10.5% per annum to 12% per annum, beginning October 1, 2019 and (ii) the Company agreed to pay Ginkgo a cash waiver fee of $1.3 million, payable in installments on December 15, 2019 and March 31, 2020.

 

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ITEM 2. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

 

The following discussion and analysis should be read in conjunction with our condensed consolidated financial statements and the related notes that appear elsewhere in this Quarterly Report on Form 10-Q. These discussions contain forward-looking statements reflecting our current expectations that involve risks and uncertainties which are subject to safe harbors under the Securities Act of 1933, as amended (the Securities Act), and the Securities Exchange Act of 1934 (the Exchange Act). These forward-looking statements include, but are not limited to, statements concerning our strategy of achieving a significant reduction in net cash outflows in 2019 and 2020, aspects of our future operations, our future financial position, including obtaining project financing for a new manufacturing facility, expectations for our future revenues, margins and projected costs, expectations regarding demand and acceptance for our technologies and products, introductions of new products, growth opportunities and trends in the market in which we operate, prospects and plans and objectives of management. The words “anticipates,” “believes,” “estimates,” “expects,” “intends,” “may,” “plans,” “projects,” “will,” “would” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. We may not actually achieve the plans, intentions or expectations disclosed in our forward-looking statements, and you should not place undue reliance on our forward-looking statements. These forward-looking statements involve risks and uncertainties that could cause our actual results to differ materially from those in the forward-looking statements, including, without limitation, the risks set forth in Part II, Item 1A, “Risk Factors” in this Quarterly Report on Form 10-Q, in Part I, Item 1A, “Risk Factors” in our 2018 10-K for the fiscal year ended December 31, 2018 (the 2018 Form 10-K) and in our other filings with the Securities and Exchange Commission. We do not assume any obligation to update any forward-looking statements.

 

Overview and Recent Developments

 

Amyris, Inc. (the Company, Amyris, we, us or our) is a leading industrial biotechnology company that applies its technology platform to engineer, manufacture and sell high performance, natural, sustainably-sourced products into the Health & Wellness, Clean Beauty, and Flavor & Fragrance markets. Our proven technology platform enables us to rapidly engineer microbes and use them as catalysts to metabolize renewable, plant-sourced sugars into large volume, high-value ingredients. Our biotechnology platform and industrial fermentation process replace existing complex and expensive manufacturing processes. We have successfully used our technology to develop and produce eight distinct molecules at commercial volumes, leading to more than 15 commercial ingredients used by thousands of leading global brands.

 

We believe that industrial synthetic biology represents a third industrial revolution, bringing together biology and engineering to generate new, more sustainable materials to meet the growing global demand for bio-based replacements for petroleum-based and traditional animal- or plant-derived ingredients. We continue to build demand for our current portfolio of products through an extensive sales network provided by our collaboration partners that represent leading companies for our target market sectors. We also have a small group of direct sales and distributors who support our Clean Beauty market. Via our partnership model, our partners invest in the development of each molecule to bring it from the lab to commercial scale and use their extensive sales force to sell our ingredients and formulations to their customers as part of their core business. We capture long-term revenue both through the production and sale of the molecule to our partners and through royalty revenues (previously referred to as value share) from our partners' product sales to their customers.

 

We were founded in 2003 in the San Francisco Bay area by a group of scientists from the University of California, Berkeley. Our first major milestone came in 2005 when, through a grant from the Bill & Melinda Gates Foundation, we developed technology capable of creating microbial strains that produce artemisinic acid, which is a precursor of artemisinin, an effective anti-malarial drug. In 2008, we granted royalty-free licenses to allow Sanofi-Aventis to produce artemisinic acid using our technology. Building on our success with artemisinic acid, in 2007 we began applying our technology platform to develop, manufacture and sell sustainable alternatives to a broad range of markets.

 

We focused our initial development efforts primarily on the production of Biofene®, our brand of renewable farnesene, a long-chain, branched hydrocarbon molecule that we manufacture through fermentation using engineered microbes. Our farnesene derivatives are sold in thousands of products as nutraceuticals, skincare products, fragrances, solvents, polymers, and lubricant ingredients. The commercialization of farnesene pushed us to create a more cost efficient, faster and accurate development process in the lab and drive manufacturing costs down. This investment has enabled our technology platform to rapidly develop microbial strains and commercialize target molecules. In 2014, we began manufacturing additional molecules for the Flavor & Fragrance industry; in 2015 we began investing to expand our capabilities to other small molecule chemical classes beyond terpenes via our collaboration with the Defense Advanced Research Projects Agency (DARPA); and in 2016 we expanded into proteins.

 

We have invested over $600 million in infrastructure and technology to create microbes that produce molecules from sugar or other feedstocks at commercial scale. This platform has been used to design, build, optimize and upscale strains producing eight distinct molecules at commercial volumes, leading to more than 15 commercial ingredients used by thousands of leading global brands. Our time to market for molecules has decreased from seven years to less than a year for our most recent molecule, mainly due to our ability to leverage the technology platform we have built.

 

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Our technology platform has been in active use since 2007 and has been integrated with our commercial production since 2011, creating an organism development process that we believe makes us an industry leader in the successful scale-up and commercialization of biotech-produced ingredients. The key performance characteristics of our platform that we believe differentiate us include our proprietary computational tools, strain construction tools, screening and analytics tools, and advanced lab automation and data integration. Having this fully integrated with our large-scale manufacturing process and capability enables us to always engineer with the end specification and requirements guiding our technology. Our state-of-the-art infrastructure includes industry-leading strain engineering and lab automation located in Emeryville, California, pilot scale production facilities in Emeryville, California and Campinas, Brazil, a demonstration-scale facility in Campinas, Brazil and a commercial-scale production facility in Leland, North Carolina, which is owned and operated by our Aprinnova joint venture to convert our Biofene into squalane and other final products.

 

We are able to use a wide variety of feedstocks for production, but have focused on accessing Brazilian sugarcane for our large-scale production because of its renewability, low cost and relative price stability. We have also successfully used other feedstocks such as sugar beets, corn dextrose, sweet sorghum and cellulosic sugars at various manufacturing facilities.

 

Several years ago, we made the strategic decision to transition our business model from collaborating and commercializing molecules in low margin commodity markets to higher margin specialty markets. We began the transition by first commercializing and supplying farnesene-derived squalane as a cosmetic ingredient sold to formulators and distributors. We also entered into collaboration and supply agreements for the development and commercialization of molecules within the Flavor & Fragrance and Clean Beauty markets where we utilize our strain generation technology to develop molecules that meet the customer’s rigorous specifications.

 

During this transition, we solidified the business model of partnering with our customers to create sustainable, high performing, low-cost molecules that replace an ingredient in their supply chain, commercially scale and manufacture those molecules, and share in the profits earned by our customers once our customer sells its product into these specialty markets. These three steps constitute our collaboration revenues, renewable product revenues, and royalty revenues (previously referred to as value share revenues).

 

During 2017, we completed several development agreements with DSM and others for new products such as Vitamin A, a human nutrition molecule and others, and in late 2018 we began commercial production and shipment of a new sweetener product developed from the Reb M molecule, which is a superior sweetener and sugar replacement. Our goal is to bring two to three new molecules per year to commercial production in the future.

 

In 2017, we decided to monetize the use of one of our lower margin molecules, farnesene, in the Vitamin E and Lubricants specialty markets while retaining any associated royalties, and licensed farnesene to Koninklijke DSM N.V. (DSM) for use in these fields. Also in 2017, we sold to DSM our subsidiary Amyris Brasil Ltda. (Amyris Brasil), which operated our purpose-built, large-scale manufacturing facility located in Brotas, Brazil.

 

The Brotas facility was built to batch manufacture one commodity product at a time (originally for high-volume production of biofuels, a business Amyris has exited), which is an inefficient manufacturing process that is not suited for the high margin specialty markets in which we operate today. We currently manufacture nine specialty products and expect to increase the number of specialty products we manufacture by two to three products a year. The inefficiencies we experienced included having to idle the facility for two weeks at a time to prepare for the next product batch manufacture. These inefficiencies caused our cost of goods sold to be significantly higher. We are building a new purpose-built, large-scale specialty ingredients plant in Brazil, which we anticipate will allow for the manufacture of five products concurrently and over 10 different products annually. As part of the December 2017 sale of Brotas, we contracted with DSM for the use of Brotas to manufacture products for us to fulfill our product supply commitments to our customers until our new production facility becomes operational.

 

In September 2019, we obtained the necessary permits and broke ground on our Specialty Ingredients Plant (SIP). We expect the facility to be fully operational in Q1 of 2021. This facility will allow us to manufacture five products at once and to produce both our specialty ingredients portfolio and our new sweetener product. During construction, we are manufacturing our products at four contract manufacturing sites in Brazil, the U.S. and Spain.

 

In addition, in May 2019 we entered into an agreement with Raizen Energia S.A. (Raizen) for the formation and operation of a joint venture relating to the production, sale and commercialization of alternative sweetener products whereby the parties would construct a manufacturing facility exclusively for sweetener molecules on land owned by Raizen and leased to the joint venture; see Note 12, “Subsequent Events” in Part I, Item 1 of this Quarterly Report on Form 10-Q for more details.

 

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Also, in May 2019, we consummated a $300 million research, collaboration and license agreement with LAVVAN, Inc., a newly formed investment-backed company (Lavvan), for the development, manufacture and commercialization of cannabinoids. Under the agreement, we would perform research and development activities and Lavvan would be responsible for the commercialization of the cannabinoids developed under the agreement. The Cannabinoid Agreement is being principally funded on a milestone basis, with Amyris also entitled to receive certain supplementary research and development funding from Lavvan. We could receive aggregate funding of up to $300 million over the term of the Cannabinoid Agreement if all of the milestones are achieved. Additionally, the agreement provides for profit share to Amyris on Lavvan's gross profit margin once products are commercialized; these payments will be due for the next 20 years.

 

Sales and Revenue

 

We recognize revenue from product sales, license fees and royalties, and grants and collaborations.

 

We have research and development collaboration arrangements for which we receive payments from our collaborators, which include DARPA, DSM, Firmenich SA (Firmenich), Givaudan International SA (Givaudan), and others. Some of our collaboration arrangements provide for advance payments to us in consideration for grants of exclusivity or research efforts that we will perform. In 2017 we signed collaboration agreements for an infant nutrition ingredient, and in 2018 we signed a collaboration agreement for two vitamins that we expect will contribute to our collaboration revenue and ultimately product sales. Our collaboration agreements, which may require us to achieve milestones prior to receiving payments, are expected to contribute revenues from product sales and royalties (previously referred to as value share) if and when they are commercialized. See Note 10, “Revenue Recognition” in Part II, Item 8 of the 2018 Form 10-K/A for additional information.

 

All of our non-government partnerships include commercial terms for the supply of molecules we successfully upscale and produce at commercial volumes. The first molecule to generate revenue for us outside of farnesene was a fragrance molecule launched in 2015. Since the launch, the product has continued to grow in sales year over year. In 2016, we launched our second fragrance molecule and in 2017, we launched our third fragrance molecule as well as our first cosmetic active ingredient. Our partners for these molecules are indicating continued strong growth due to their cost advantaged position, high purity and sustainable production method. We are continuing to identify new opportunities to apply our technology and deliver sustainable access to key molecules. As a result, we have a pipeline that we believe can deliver two to three new molecules each year over the coming years with a flavor ingredient, a cosmetic active ingredient and a fragrance molecule. In 2019, we are commercially producing and shipping our Reb M product that is a superior sweetener and sugar replacement for food and beverages.

 

As part of the DSM acquisition in 2017 of our farnesene for Vitamin E business, we would receive a royalty payment on certain sales by Nenter & Co., Inc. of Vitamin E utilizing farnesene produced and sold by DSM from our technology. In addition, DSM would be obligated to pay us minimum royalties totaling $18.1 million for 2019 and 2020, of which we received $9.3 million as a discounted accelerated payment (from an original payment amount of $10.0 million) during 2018. In April 2019, we assigned the right to receive such royalty payments to DSM; see Note 12, “Subsequent Events” in Part 1, Item 1 of this Quarterly Report on Form 10-Q for additional information.

 

We have several other collaboration molecules in our development pipeline with partners including DSM, Givaudan and Firmenich that we expect will contribute revenues from product sales and royalties (previously referred to as value share) if and when they are commercialized.

 

Critical Accounting Policies and Estimates

 

Management's discussion and analysis of results of operations and financial condition are based on our consolidated financial statements, which have been prepared in accordance with accounting principles generally accepted in the U.S. (U.S. GAAP). We believe that the critical accounting policies described in this section are those that significantly impact our financial condition and results of operations and require the most difficult, subjective or complex judgements, often as a result of the need to make estimates about the effects of matters that are inherently uncertain. Because of this uncertainty, actual results may vary from these estimates.

 

Our most critical accounting estimates include:

Recognition of revenue including arrangements with multiple performance obligations;
Valuation and allocation of fair value to various elements of complex related party transactions;
The valuation of freestanding and embedded derivatives, which impacts gains or losses on such derivatives, the carrying value of debt, preferred stock, interest expense and deemed dividends; and
The valuation of debt for which we have elected fair value accounting.

 

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For more information about our critical accounting estimates and policies, see Note 1, "Basis of Presentation and Summary of Significant Accounting Policies" in Part I, Item 1 of this Quarterly Report on Form 10-Q and in Part II, Item 8 of the 2018 10-K/A.

 

Results of Operations

 

Revenue

 

   Three Months Ended March 31,
(In thousands)  2019  2018
Revenue      
Renewable products  $11,884   $5,195 
Licenses and royalties   118    7,955 
Grants and collaborations   2,372    4,709 
Total revenue  $14,374   $17,859 

 

Three Months Ended March 31, 2019 and 2018

 

Total revenue decreased by 20% to $14.4 million for the three months ended March 31, 2019, compared to the same period in 2018. The decrease was primarily due to a $7.8 million decrease in licenses and royalties revenue and $2.3 million decrease in grants and collaborations revenue, mostly offset by a $6.7 million increase in renewable products revenue.

 

Renewable products revenue increased by 129% to $11.9 million for the three months ended March 31, 2019 compared to the same period in 2018, with increases among all renewable products, led by RebM, Squalene and Biossance.

 

Licenses and royalties revenue decreased by 99% to $0.1 million for the three months ended March 31, 2019 compared to the same period in 2018, primarily due to negative $0.4 million of royalty revenue from DSM (related to an early payment discount) during the current period as compared to $7.9 million during the prior year period.

 

Grants and collaborations revenue decreased by 50% to $2.4 million for the three months ended March 31, 2019, compared to the same period in 2018, primarily due to $0 revenue from Givaudan in 2019 as compared to $1.5 million in 2018, and a $0.7 million decrease in collaboration revenue from DARPA.

 

Costs and Operating Expenses

 

   Three Months Ended March 31,
(In thousands)  2019  2018
Cost and operating expenses          
Cost of products sold  $17,707   $5,315 
Research and development   17,839    17,825 
Sales, general and administrative   28,253    18,100 
Total cost and operating expenses  $63,799   $41,240 

 

Cost of Products Sold

 

Cost of products sold includes the raw materials, labor and overhead, amounts paid to contract manufacturers, inventory write-downs, and costs related to production scale-up. Because of our product mix, our overall cost of products sold does not necessarily increase or decrease proportionately with changes in our renewable product revenues.

 

Three Months Ended March 31, 2019 and 2018

 

Cost of products sold increased by 233% to $17.7 million for the three months ended March 31, 2019, compared to the same period in 2018, primarily due to costs associated with ramping up our RebM sweetener product, which we began shipping in late 2018, and to a lesser extent an increase in volume of products sold.

 

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Research and Development Expenses

 

Three Months Ended March 31, 2019 and 2018

 

Research and development expenses were flat at $17.8 million for the three months ended March 31, 2019, compared to the same period in 2018.

 

Sales, General and Administrative Expenses

 

Three Months Ended March 31, 2019 and 2018

 

Sales, general and administrative expenses increased by 56% to $28.3 million for the three months ended March 31, 2019, compared to the same period in 2018, primarily due to increases in employee compensation, outside services and audit fees. The increase in employee compensation was driven by increased head count, the timing of changes in our compensation plan for most non-executive level employees, and increased stock-based compensation related to increased head count.

 

Other (Expense) Income, Net

 

   Three Months Ended March 31,
(In thousands)  2019  2018
Other income (expense):          
Loss on divestiture  $   $(1,778)
Interest expense   (12,534)   (9,978)
Loss from change in fair value of derivative instruments   (2,039)   (58,357)
Loss from change in fair value of debt   (2,130)    
Other income (expense), net   (115)   692 
Total other income (expense), net  $(16,818)  $(69,421)

 

Three Months Ended March 31, 2019 and 2018

 

Total other expense, net was $16.8 million for the three months ended March 31, 2019, compared to total other expense, net of $69.4 million for the same period in 2018. The $52.6 million decrease was primarily due to a $56.3 million decrease in loss from change in fair value of derivative instruments, partly offset by a $2.6 million increase in interest expense and a $2.1 million loss from change in fair value of debt. The decrease in loss from change in fair value of derivative instruments was due to the extinguishment of certain equity-related derivatives in the second and third quarter of 2018, which are no longer impacting the 2019 quarters, and in part as the result of adopting ASU 2017-11, "Earnings Per Share (Topic 260); Distinguishing Liabilities from Equity (Topic 480); Derivatives and Hedging (Topic 815): Accounting for Certain Financial Instruments with Down Round Features" which eliminated the need to record a derivative liability for equity instruments with down-round anti-dilution provisions. See Note 1, "Basis of Presentation and Summary of Significant Accounting Policies" and Note 3, "Fair Value Measurement" for a discussion of the adoption impact to our condensed consolidated financial statements.

 

Provision for Income Taxes

 

Three Months Ended March 31, 2019 and 2018

 

For the three months ended March 31, 2019 and 2018, we recorded $0 provisions for income taxes. No additional provision for income taxes has been made, net of the valuation allowance, due to cumulative losses since the commencement of operations.

 

Liquidity and Capital Resources

 

(In thousands)  March 31,
2019
  December 31,
2018
Working capital deficit  $(199,436)  $(119,521)
Cash and cash equivalents  $5,153   $45,353 
Debt and lease obligations(1)  $246,101   $210,376 
Accumulated deficit  $(1,579,129)  $(1,521,417)

 

(1) Lease obligations at December 31, 2018 include capital leases (which at March 31, 2019 are described as financing leases), but do not include operating leases. Lease obligations at March 31, 2019 also include operating lease liabilities upon the adoption of ASC 842, "Leases". See Part I, Item 1, Note 2, for additional information.

 

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   Three Months Ended March 31,
(In thousands)  2019  2018
Net cash (used in) provided by:          
Operating activities  $(36,980)  $(25,169)
Investing activities  $(3,046)  $(1,584)
Financing activities  $(222)  $(6,694)

 

Liquidity. We have incurred significant operating losses since our inception, and we expect to continue to incur losses and negative cash flows from operations through at least the next 12 months following issuance of the condensed consolidated financial statements. As of March 31, 2019, we had negative working capital, excluding cash and cash equivalents and short-term investments, of $199.4 million, (compared to negative working capital (excluding cash) of $119.5 million as of December 31, 2018), an accumulated deficit of $1.6 billion, and cash and cash equivalents of $5.2 million (compared to $45.4 million as of December 31, 2018).

 

As of March 31, 2019, our debt (including related party debt), net of deferred discount and issuance costs of $13.5 million, totaled $215.8 million, of which $153.8 million is classified as current. Our debt service obligations through March 31, 2020 are $179.8 million, including $23.5 million of anticipated cash interest payments. Our debt agreements contain various covenants, including certain restrictions on our business that could cause us to be at risk of defaults, such as restrictions on additional indebtedness and cross-default clauses. A failure to comply with the covenants, or cure non-compliance or obtain waivers for covenants violations, and other provisions of our debt instruments, including any failure to make a payment when required, would generally result in events of default under such instruments, which could permit acceleration of such indebtedness. If such indebtedness is accelerated, it would generally also constitute an event of default under our other outstanding indebtedness, permitting acceleration of a substantial portion of our outstanding indebtedness.

 

On September 16, 2019, we failed to pay an aggregate of $63.6 million of outstanding principal and accrued interest on the Second Exchange Note when due. The failure resulted in an event of default under the Second Exchange Note and also triggered cross-defaults under other debt instruments of Amyris which permitted the holders of such indebtedness to accelerate the amounts owing under such instruments. We subsequently received waivers from substantially all holders of such other debt instruments to waive the right to accelerate. As a result, the indebtedness with respect to which Amyris has obtained such waivers continues to be classified as long-term on our balance sheet.  The indebtedness reflected by the Second Exchange Note continues to be classified as a current liability on our balance sheet. In addition, as a result of the payment default, the conversion price of the Second Exchange Note is subject to adjustment in accordance with the terms of the Second Exchange Note.

 

We do not currently have sufficient funds to repay the amounts outstanding under the Second Exchange Note. To date, negotiations with the holder of the Second Exchange Note have not been successful, and there can be no assurance that a favorable outcome for us will be reached. We have executed a term sheet with an existing investor for a term loan, the proceeds of which would be used to repay a portion of the Second Exchange Note. However, there can be no assurance that we will be able to obtain such financing on its expected timeline, or on acceptable terms, if at all. Even if we do obtain such financing, it will not have sufficient funds to repay the Second Exchange Note in full without obtaining additional financing, which we are attempting to source. The condensed consolidated financial statements do not include any adjustments that might result from the outcome of this uncertainty.

 

Our consolidated financial statements as of and for the three months ended March 31, 2019 have been prepared on the basis that we will continue as a going concern, which contemplates the realization of assets and satisfaction of liabilities in the normal course of business. Due to the factors described above, there is substantial doubt about our ability to continue as a going concern within one year after the date that these condensed consolidated financial statements are issued. Our ability to continue as a going concern will depend, in large part, on our ability to extend existing debt maturities by restructuring a majority of our convertible debt, which is uncertain and outside management's control. The condensed consolidated financial statements do not include any adjustments that might result from the outcome of this uncertainty, which could have a material adverse effect on our financial condition. In addition, if we are unable to continue as a going concern, we may be unable to meet our obligations under our existing debt facilities, which could result in an acceleration of our obligation to repay all amounts outstanding under those facilities, and we may be forced to liquidate our assets. In such a scenario, the values we receive for our assets in liquidation or dissolution could be significantly lower than the values reflected in our financial statements.

 

Our operating plan for the next 12 months contemplates a significant reduction in our net cash outflows, resulting from (i) revenue growth from sales of existing and new products with positive gross margins, (ii) reduced production costs as a result of manufacturing and technical developments, and (iii) cash inflows from grants and collaborations.

 

If we are unable to generate sufficient cash contributions from product sales, licenses and royalties, and payments from existing and new collaboration partners, and new financing commitments due to contractual restrictions and covenants, we may need to obtain additional funding from equity or debt financings, which may not occur in a timely manner or on reasonable terms, if at all, agree to burdensome covenants, grant further security interests in our assets, enter into collaboration and licensing arrangements that require us to relinquish commercial rights, or grant licenses on terms that are not favorable.

 

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If we do not achieve our planned operating results, our ability to continue as a going concern would be jeopardized and we may need to take the following actions to support our liquidity needs during the next 12 months:

Shift focus to existing products and customers with significantly reduced investment in new product and commercial development efforts;
Reduce expenditures for third party contractors, including consultants, professional advisors and other vendors;
Reduce or delay uncommitted capital expenditures, including expenditures related to the construction and commissioning of the new production facility in Brazil, non-essential facility and lab equipment, and information technology projects; and
Closely monitor our working capital position with customers and suppliers, as well as suspend operations at pilot plants and demonstration facilities.

 

Implementing this plan could have a negative impact on our ability to continue our business as currently contemplated, including, without limitation, delays or failures in our ability to:

Achieve planned production levels;
Develop and commercialize products within planned timelines or at planned scales; and
Continue other core activities.

 

We expect to fund operations for the foreseeable future with cash and investments currently on hand, cash inflows from collaborations, grants, product sales, license and royalties and equity and debt financings, to the extent necessary. Some of our research and development collaborations are subject to risk that we may not meet milestones. Future equity and debt financings, if needed, are subject to the risk that we may not be able to secure financing in a timely manner or on reasonable terms, if at all. Our planned working capital and capital expenditure needs for the remainder of 2019 are dependent on significant inflows of cash from renewable product sales, license and royalties and existing collaboration partners, as well as additional funding from new collaborations.

 

Cash Flows during the Three Months Ended March 31, 2019 and 2018

 

Cash Flows from Operating Activities

 

Our primary uses of cash from operating activities are costs related to the production and sale of our products and personnel-related expenditures, offset by cash received from renewable product sales, licenses and royalties, and grants and collaborations.

 

For the three months ended March 31, 2019, net cash used in operating activities was $37.0 million, consisting primarily of a $66.2 million net loss, partially offset by $16.3 million of favorable non-cash adjustments that were primarily comprised of $4.6 million of debt discount amortization, $3.5 million of stock-based compensation and a $2.1 million loss on change in fair value of debt. Additionally, there was a $13.0 million decrease in working capital.

 

For the three months ended March 31, 2018, net cash used in operating activities was $25.2 million, consisting of a $92.8 million net loss, $67.3 million of favorable non-cash adjustments and a $0.4 million decrease in working capital. The non-cash adjustments were primarily comprised of a $58.4 million loss from change in fair value of derivative liabilities and $4.8 million of debt discount amortization.

 

Cash Flows from Investing Activities

 

For the three months ended March 31, 2019 and March 31, 2018, net cash used in investing activities was $3.0 million, and $1.6 million, respectively, comprised of property, plant and equipment purchases.

 

Cash Flows from Financing Activities

 

For the three months ended March 31, 2019, net cash used in financing activities was $0.2 million, primarily comprised of $0.6 million of debt principal payments, partly offset by $0.5 million of net proceeds from debt issuance.

 

For the three months ended March 31, 2018, net cash used in financing activities was $6.7 million, primarily comprised of $6.5 million of debt principal payments.

 

41

Off-Balance Sheet Arrangements

 

March 31, 2019, we did not have any material off-balance sheet arrangements, as defined in Item 303(a)(4)(ii) of Regulation S-K.

 

Contractual Obligations

 

The following is a summary of our contractual obligations as of March 31, 2019:

 

Payable by year ending December 31,
(In thousands)
  Total  2019  2020  2021  2022  2023  Thereafter
Principal payments on debt  $229,517   $112,038   $26,451   $76,493   $12,281   $293   $1,961 
Interest payments on debt (1)   38,622    15,704    12,588    8,747    1,170    106    307 
Financing and operating leases   40,090    13,123    9,308    7,227    7,398    3,034     
Manufacturing reservation fee   21,036    21,036                     
Partnership payment obligation   11,906    3,175    3,175    3,175    2,381         
Inducement fee   4,585    2,745    1,840                 
Total  $345,756   $167,821   $53,362   $95,642   $23,230   $3,433   $2,268 

 

____________________

(1)Does not include any obligations related to make-whole interest or down-round provisions. Fixed and variable interest rates are described in Note 5, "Debt" in Part II, Item 8 of this Annual Report on Form 10-K/A. Future interest payments shown above for variable-rate debt instruments are measured on the basis of interest rates for such instruments as of March 31, 2019. The fixed interest rates are more fully described in Note 5, "Debt" in Part II, Item 8 of the 2018 10-K/A.

 

42

 

ITEM 4. CONTROLS AND PROCEDURES

 

Evaluation of Disclosure Controls and Procedures

 

We maintain disclosure controls and procedures, as such term is defined under Rule 13a-15(e) promulgated under the Securities Exchange Act of 1934 (Exchange Act). In designing and evaluating the disclosure controls and procedures, management recognizes that any disclosure controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving the desired control objectives, and management necessarily is required to apply its judgment in evaluating the cost-benefit of possible controls and procedures.

 

Under the supervision and with the participation of management, including our principal executive officer and principal financial officer, we conducted an evaluation of the effectiveness of our disclosure controls and procedures as of the end of the period covered by this report. Based on this evaluation, our principal executive officer and principal financial officer have concluded that our disclosure controls and procedures were not effective at the reasonable assurance level as of March 31, 2019. This conclusion was based on the material weaknesses in our internal control over financial reporting described in Part II, Item 9A “Controls and Procedures” of our Annual Report on Form 10-K/A for the fiscal year ended December 31, 2018 (the 2018 Form 10-K/A). The material weaknesses have not been remediated as of March 31, 2019.

 

A material weakness is a deficiency, or combination of deficiencies, in internal control over financial reporting such that there is a reasonable possibility that a material misstatement of the Company’s annual or interim consolidated financial statements will not be prevented or detected on a timely basis. If not remediated, the material weakness in our internal control over financial reporting described in the 2018 Form 10-K/A could result in a material misstatement of our annual or interim consolidated financial statements that would not be prevented or detected on a timely basis.

 

Changes in Internal Control over Financial Reporting

 

During the fiscal quarter ended March 31, 2019, there were no changes in our internal control over financial reporting during the fiscal quarter ended March 31, 2019 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

 

Inherent Limitations on Effectiveness of Controls

 

Our management, including our principal executive officer and principal financial officer, does not expect that our disclosure controls and procedures or our internal control over financial reporting will prevent or detect all errors and all fraud. A control system, no matter how well-designed and operated, can provide only reasonable, not absolute, assurance that the control system’s objectives will be met. The design of a control system must reflect the fact that there are resource constraints, and the benefits of controls must be considered relative to their costs. Further, because of the inherent limitations in all control systems, no evaluation of controls can provide absolute assurance that misstatements due to error or fraud will not occur or that all control issues and instances of fraud, if any, have been detected. The design of any system of controls is based in part on certain assumptions about the likelihood of future events, and there can be no assurance that any design will succeed in achieving its stated goals under all potential future conditions. Projections of any evaluation of the effectiveness of controls to future periods are subject to risks. Over time, controls may become inadequate because of changes in conditions or deterioration in the degree of compliance with policies or procedures.

 

 

 

43

PART II

ITEM 1. LEGAL PROCEEDINGS

 

On April 3, 2019, a securities class action complaint was filed against Amyris and our CEO, John G. Melo, and former CFO (and current Chief Business Officer), Kathleen Valiasek, in the U.S. District Court for the Northern District of California. The complaint seeks unspecified damages on behalf of a purported class that would comprise all persons and entities that purchased or otherwise acquired our securities between March 15, 2018 and March 19, 2019. The complaint alleges securities law violations based on statements and omissions made by the Company during such period. Subsequent to the filing of the securities class action complaint described above, on June 21, 2019 and October 1, 2019, respectively, two separate purported shareholder derivative complaints were filed in the U.S. District Court for the Northern District of California (Bonner v. Doerr, et al., Case No. 4:19-cv-03621 and Carlson v. Doerr, et al., Case No. 4:19-cv-06230) based on similar allegations to those made in the securities class action complaint described above. The derivative complaints name Amyris, Inc. as a nominal defendant and name a number of the Company’s current and former officers and directors as additional defendants. The lawsuits seek to recover, on the Company's behalf, unspecified damages purportedly sustained by the Company in connection with allegedly misleading statements and omissions made in connection with the Company’s securities filings. The derivative complaints also seek a series of changes to the Company’s corporate governance policies, restitution to the Company from the individual defendants, and an award of attorneys’ fees. These cases are in the initial pleadings stage. We believe the complaints lack merit, and intend to defend ourselves vigorously. Given the early stage of these proceedings, it is not yet possible to reliably determine any potential liability that could result from these matters.

 

We may be involved, from time to time, in legal proceedings and claims arising in the ordinary course of our business. Such matters are subject to many uncertainties and there can be no assurance that legal proceedings arising in the ordinary course of business or otherwise will not have a material adverse effect on our business, results of operations, financial position or cash flows.

 

ITEM 1A. RISK FACTORS

 

The risks described in Part I, Item 1A, "Risk Factors" in our Annual Report on Form 10-K for the fiscal year ended December 31, 2018 (the 2018 Form 10-K) could materially and adversely affect our business, financial condition and results of operations, and the trading price of our common stock could decline. These risk factors do not identify all risks that we face; our operations could also be affected by factors that are not presently known to us or that we currently consider to be immaterial to our operations. Due to risks and uncertainties, known and unknown, our past financial results may not be a reliable indicator of future performance, and historical trends should not be used to anticipate results or trends in future periods. The “Risk Factors” section of the 2018 Form 10-K remains current in all material respects.

 

ITEM 2. UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS

 

None.

 

ITEM 3. DEFAULTS UPON SENIOR SECURITIES

 

None.

 

ITEM 5. OTHER INFORMATION

 

None.

 

ITEM 6. EXHIBITS

 

Exhibit  
No. Description
31.01 Certification of Chief Executive Officer pursuant to Securities Exchange Act Rules 13a-14(c) and 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002
31.02 Certification of Chief Financial Officer pursuant to Securities Exchange Act Rules 13a-14(c) and 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002
32.01a Certification of Chief Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
32.02 a Certification of Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
101.INS XBRL Instance Document
101.SCH XBRL Taxonomy Extension Schema Document
101.CAL XBRL Taxonomy Extension Calculation Linkbase Document
101.DEF XBRL Taxonomy Extension Definition Linkbase Document
101.LAB XBRL Taxonomy Extension Label Linkbase Document
101.PRE XBRL Taxonomy Extension Presentation Linkbase Document

 

a This certification shall not be deemed “filed” for purposes of Section 18 of the Exchange Act or otherwise subject to the liability of that section, nor shall it be deemed incorporated by reference into any filing under the Securities Act or the Exchange Act.

 

44

SIGNATURES

 

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this Quarterly Report on Form 10-Q to be signed on its behalf by the undersigned, thereunto duly authorized.

 

 

    AMYRIS, INC.  
       
  By: /s/ John G. Melo  
    John G. Melo  
    President and Chief Executive Officer
(Principal Executive Officer)
 
    October 7, 2019  
       
  By: /s/ Jonathan Wolter  
    Jonathan Wolter  
    Interim Chief Financial Officer  
(Principal Financial Officer)
 
    October 7, 2019  

 

 

45

 

 

EX-31.01 2 exh_3101.htm EXHIBIT 31.01

Exhibit 31.01

 

CERTIFICATION OF CHIEF EXECUTIVE OFFICER

PURSUANT TO RULE 13a-14(c) and 15d-(14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

 

I, John G. Melo, certify that:

 

1.       I have reviewed this Quarterly Report on Form 10-Q of Amyris, Inc.;

 

2.       Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

 

3.       Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

 

4.       The registrant's other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

 

a)       Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

 

b)       Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

 

c)       Evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

 

d)       Disclosed in this report any change in the registrant's internal control over financial reporting that occurred during the registrant's most recent fiscal quarter (the registrant's fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting; and

 

5.       The registrant's other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):

 

a)       All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and

 

b)       Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.

 

 

Date: October 7, 2019 /s/ John G. Melo
  John G. Melo
  President and Chief Executive Officer

EX-31.02 3 exh_3102.htm EXHIBIT 31.02

Exhibit 31.02

 

CERTIFICATION OF CHIEF FINANCIAL OFFICER

PURSUANT TO RULE 13a-14(c) and 15d-(14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

 

I, Jonathan Wolter, certify that:

 

1.       I have reviewed this Quarterly Report on Form 10-Q of Amyris, Inc.;

 

2.       Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

 

3.       Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

 

4.       The registrant's other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

 

a)       Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

 

b)       Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

 

c)       Evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

 

d)       Disclosed in this report any change in the registrant's internal control over financial reporting that occurred during the registrant's most recent fiscal quarter (the registrant's fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting; and

 

5.       The registrant's other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):

 

a)       All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and

 

b)       Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.

 

 

Date: October 7, 2019 /s/ Jonathan Wolter
  Jonathan Wolter
  Interim Chief Financial Officer

EX-32.01 4 exh_3201.htm EXHIBIT 32.01

Exhibit 32.01

 

Certification of CEO Furnished Pursuant to 18 U.S.C. Section 1350,

As Adopted Pursuant To

Section 906 of The Sarbanes-Oxley Act of 2002

 

In connection with the Quarterly Report of Amyris, Inc. (the “Company”) on Form 10-Q for the quarterly period ended March 31, 2019, as filed with the Securities and Exchange Commission on the date hereof, I, John G. Melo, Chief Executive Officer of the Company, certify for the purposes of section 1350 of chapter 63 of title 18 of the United States Code, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that, to the best of my knowledge,

 

(i) the Quarterly Report of the Company on Form 10-Q for the quarterly period ended March 31, 2019 (the “Report”), fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934, and

 

(ii) the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

 

 

Date: October 7, 2019 /s/ John G. Melo
  John G. Melo
  President and Chief Executive Officer
  (Principal Executive Officer)

EX-32.02 5 exh_3202.htm EXHIBIT 32.02

Exhibit 32.02

 

Certification of CFO Furnished Pursuant to 18 U.S.C. Section 1350,

As Adopted Pursuant To

Section 906 of The Sarbanes-Oxley Act of 2002

 

In connection with the Quarterly Report of Amyris, Inc. (the “Company”) on Form 10-Q for the quarterly period ended March 31, 2019, as filed with the Securities and Exchange Commission on the date hereof, I, Jonathan Wolter, Interim Chief Financial Officer of the Company, certify for the purposes of section 1350 of chapter 63 of title 18 of the United States Code, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that, to the best of my knowledge,

 

(i) the Quarterly Report of the Company on Form 10-Q for the quarterly period ended March 31, 2019 (the “Report”), fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934, and

 

(ii) the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

 

 

Date: October 7, 2019 /s/ Jonathan Wolter
  Jonathan Wolter
  Interim Chief Financial Officer
  (Principal Financial Officer)

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background-color: rgb(204,238,255)"> <td style="width: 46%; text-align: left">2019 (remaining nine months)</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">368</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,755</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,123</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2020</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">199</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,109</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,308</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">2021</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,226</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,227</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2022</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,398</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,398</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">2023</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,034</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,034</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Thereafter</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Total lease payments</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">568</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">39,522</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">40,090</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left"><div style=" margin: 0pt 0">Less: amount representing interest</div> </td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(23</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(9,793</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(9,816</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Total lease liability</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">545</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29,729</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">30,274</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Current lease liability</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">452</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,972</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,424</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Noncurrent lease liability</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">93</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,757</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,850</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Total lease liability</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">545</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29,729</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">30,274</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> P1Y P5Y 3000000 2000000 3000000 3000000 2000000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Going Concern</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;">&nbsp;</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The Company has incurred significant operating losses since its inception and expects to continue to incur losses and negative cash flows from operations for at least the next <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12</div> months following the issuance of these condensed consolidated financial statements. As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> the Company had negative working capital of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$199.4</div> million (compared to negative working capital of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$119.5</div> million as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>), and an accumulated deficit of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.6</div> billion.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> the Company's debt (including related party debt), net of debt discount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$13.5</div> million, totaled <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$215.8</div> million, of which <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$153.8</div> million is classified as current. Subsequent to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> the Company entered into arrangements with lenders to extend maturities and convert certain debt obligations into common stock; see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,</div> "Subsequent Events" for more information. The Company's debt service obligations through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2020</div> are <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$179.8</div> million, including <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$23.5</div> million of anticipated cash interest payments. The Company's debt agreements contain various covenants, including certain restrictions on the Company's business that could cause the Company to be at risk of defaults, such as restrictions on additional indebtedness and cross-default clauses. A failure to comply with, or cure non-compliance events or obtain waivers for covenant violations, and other provisions of the Company&#x2019;s debt instruments, including any failure to make a payment when required, would generally result in events of default under such instruments, which could permit acceleration of such indebtedness. If such indebtedness is accelerated, it would generally also constitute an event of default under the Company&#x2019;s other outstanding indebtedness, permitting acceleration of a substantial portion of the Company's outstanding indebtedness.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Cash and cash equivalents of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.2</div> million as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> are <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> sufficient to fund expected future negative cash flows from operations and cash debt service obligations through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2020.</div> These factors raise substantial doubt about the Company&#x2019;s ability to continue as a going concern within <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> year after the date that these condensed consolidated financial statements are issued. The condensed consolidated financial statements do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> include any adjustments that might result from the outcome of this uncertainty. The Company's ability to continue as a going concern will depend, in large part, on its ability to extend existing debt maturities by restructuring a majority of its convertible debt, which is uncertain and outside the control of the Company. Further, the Company's operating plan for the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">twelve</div> months ending <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 31, 2020 </div>contemplates a significant reduction in its net operating cash outflows as compared to the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> resulting from (i) revenue growth from sales of existing and new products with positive gross margins, (ii) significantly increased cash inflows from grants and collaborations, and (iii) reduced production costs as a result of manufacturing and technical developments. If the Company is unable to complete these actions, it expects to be unable to meet its operating cash flow needs and its obligations under its existing debt facilities. This could result in an acceleration of its obligation to repay all amounts outstanding under those facilities, and it <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be required to obtain additional equity or debt financing, which <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> occur timely or on reasonable terms, if at all, and/or liquidate its assets. In such a scenario, the value the Company receives for its assets in liquidation or dissolution could be significantly lower than the value reflected in these condensed consolidated financial statements.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <!-- Field: Page; Sequence: 10; Value: 4 --> <!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 16, 2019, </div>the Company failed to pay an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$63.6</div> million of outstanding principal and accrued interest on the Second Exchange Note when due. The failure resulted in an event of default under the Second Exchange Note and also triggered cross-defaults under other debt instruments of the Company which permitted the holders of such indebtedness to accelerate the amounts owing under such instruments. The Company subsequently received waivers from substantially all holders of such other debt instruments to waive the right to accelerate. As a result, the indebtedness with respect to which the Company has obtained such waivers continues to be classified as long-term on the Company&#x2019;s balance sheet.&nbsp; The indebtedness reflected by the Second Exchange Note continues to be classified as a current liability on the Company&#x2019;s balance sheet. In addition, as a result of the payment default, the conversion price of the Second Exchange Note is subject to adjustment in accordance with the terms of the Second Exchange Note.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> currently have sufficient funds to repay the amounts outstanding under the Second Exchange Note. To date, negotiations with the holder of the Second Exchange Note have <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> been successful, and there can be <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> assurance that a favorable outcome for the Company will be reached. The Company has executed a term sheet with an existing investor for a term loan, the proceeds of which would be used to repay a portion of the Second Exchange Note. However, there can be <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> assurance that the Company will be able to obtain such financing on its expected timeline, or on acceptable terms, if at all. Even if the Company does obtain such financing, it will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> have sufficient funds to repay the Second Exchange Note in full without obtaining additional financing, which the Company is attempting to source. The condensed consolidated financial statements do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> include any adjustments that might result from the outcome of this uncertainty.</div></div></div></div></div></div></div></div></div></div></div> 179800000 23500000 153752000 147677000 62075000 62020000 24400000 7250000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.</div> Mezzanine Equity</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 23pt">Mezzanine equity is comprised of the following:</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 23pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold">(In thousands)</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">March 31, 2019</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 58%; text-align: left; padding-bottom: 2.5pt">Contingently redeemable common stock</td> <td style="width: 1%; padding-bottom: 2.5pt">&nbsp;</td> <td style="width: 1%; border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="width: 18%; border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,000</div></td> <td style="width: 1%; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="width: 1%; padding-bottom: 2.5pt">&nbsp;</td> <td style="width: 1%; border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="width: 18%; border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,000</div></td> <td style="width: 1%; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 23pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 23pt">Mezzanine equity at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> is comprised of proceeds from shares of common stock sold on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 10, 2016 </div>to the Bill&nbsp;&amp; Melinda Gates Foundation (Gates Foundation). In connection with the stock sale, the Company and the Gates Foundation entered into an agreement under which the Company agreed to expend an aggregate amount <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> less than the proceeds from the stock sale to develop a yeast strain that produces artemisinic acid and/or amorphadiene at a low cost and to supply such artemisinic acid and amorphadiene to companies qualified to convert artemisinic acid and amorphadiene to artemisinin for inclusion in artemisinin combination therapies used to treat malaria. If the Company defaults in its obligation to use the proceeds from the stock sale as set forth above or defaults under certain other commitments in the agreement, the Gates Foundation will have the right to request that the Company redeem, or facilitate the purchase by a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">third</div> party, the shares then held by the Gates Foundation at a price per share equal to the greater of (i) the closing price of the Company&#x2019;s common stock on the trading day prior to the redemption or purchase, as applicable, or (ii) an amount equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$17.10</div> plus a compounded annual return of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10%.</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 23pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 23pt">As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> the Company's remaining research and development obligation under this arrangement was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.6</div> million.</div></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold">(In thousands)</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">March 31, 2019</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 58%; text-align: left; padding-bottom: 2.5pt">Contingently redeemable common stock</td> <td style="width: 1%; padding-bottom: 2.5pt">&nbsp;</td> <td style="width: 1%; border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="width: 18%; border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,000</div></td> <td style="width: 1%; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="width: 1%; padding-bottom: 2.5pt">&nbsp;</td> <td style="width: 1%; border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="width: 18%; border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,000</div></td> <td style="width: 1%; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> 41043000 605000 264000 30274000 11424000 18850000 2826000 758000 800000 7300000 3046000 1584000 200000 100000 50000000 956000 631000 2964000 3005000 600000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="31" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Three Months Ended March 31,</td> </tr> <tr style="vertical-align: bottom"> <td style="text-align: left"><div style="display: inline; font-weight: bold;">(In thousands)</div></td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2019</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> </tr> <tr style="vertical-align: bottom"> <td style="font-weight: bold; text-align: center">&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Renewable Products</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Licenses and Royalties</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Grants and Collaborations</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Renewable Products</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Licenses and Royalties</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Grants and Collaborations</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 20%">Firmenich</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,891</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">498</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">728</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,117</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">207</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">37</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,267</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,511</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Givaudan</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,575</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,575</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,076</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,500</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,576</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">American Sugar Refining</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,494</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,494</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">DSM - related party</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(380</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">396</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,918</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">734</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,652</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-left: 20pt; text-indent: -10pt; white-space: nowrap">Subtotal revenue from significant revenue agreements</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,962</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">118</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,124</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,204</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,283</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,955</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,501</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,739</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">Revenue from all other customers</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,922</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,248</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,170</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,912</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,208</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,120</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 2.5pt; padding-left: 10pt">Total revenue from all customers</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,884</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">118</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,372</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">14,374</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,195</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,955</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,709</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">17,859</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> 17600000 1800000 29713000 30472000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; margin-left: 49.5pt; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">March 31, 2019</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">DSM manufacturing capacity fee</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style=" margin: 0pt 0">7,250</div></div> </td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 64%; text-align: left">Contract termination fees</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left"></td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,337</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left"></td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,247</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Accrued interest</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,094</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,853</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Payroll and related expenses</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,285</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,220</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Asset retirement obligation</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,111</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,063</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Tax-related liabilities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,589</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,139</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Professional services</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,871</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,173</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="padding-bottom: 1pt">Other</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,054</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,284</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 2.5pt; padding-left: 10pt">Total accrued and other current liabilities</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">33,591</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28,979</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold">(In thousands)</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">March 31, 2019</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid">December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Accounts receivable:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 64%; padding-left: 10pt">DSM</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,334</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,071</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="padding-left: 10pt">Novvi</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">188</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="padding-bottom: 1pt; padding-left: 10pt">Total</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">90</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,334</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,349</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Accounts receivable, unbilled, current:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="padding-left: 10pt">DSM</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,021</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Accounts receivable, unbilled, noncurrent:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="padding-left: 10pt">DSM</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,203</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,203</div></td> <td style="text-align: left">&nbsp;</td> </tr> </table></div> 5153107 5.39 P1Y182D 479751 471204 8547 479751 450568 162392 450568 0.1999 0.1999 0.05 0.0999 0.1 -199400000 -119500000 false --12-31 Q1 2019 2019-03-31 10-Q 0001365916 103400207 Yes false Accelerated Filer AMYRIS, INC. false true Common Stock amrs 28604000 26844000 1334000 1071000 188000 90000 1334000 1349000 1334000 1349000 33591000 28979000 1871000 1173000 682000 868000 79144000 78631000 -42379000 -43343000 32500000 398000 398000 3452000 3452000 1278000 1278000 663000 363000 2789000 915000 3452000 1278000 4628000 4789000 5427384 1365447 12699607 8347364 26411761 29759452 5493579 706697 2955732 4504212 52988063 44683172 25700000 105147000 127925000 36268000 92215000 6440000 200000 5153000 45353000 24084000 5200000 47054000 61012000 6736000 27497000 -40318000 -33515000 0.01 2.87 7.52 2.87 5.12 3.90 4.56 3.90 3.90 2.87 5.02 3.90 4.76 5.02 5.02 5.02 5.12 2.87 3.90 3.31 1438829 4871795 5424804 3983230 1635025 1212787 258704 995024 2000000 181818 2000000 2000000 1080000 3205128 12097164 12097164 6292798 6292798 3968116 3968116 3616174 3616174 663228 192024 171429 171429 81197 72650 1406 1406 26891512 26411761 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9.</div> Revenue Recognition and Contract Assets and Liabilities</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Disaggregation of Revenue</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The following table presents revenue by major product and service, as well as by primary geographical market, based on the location of the customer:</div> <div style=" margin: 0pt 0">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="31" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Three Months Ended March 31,</td> </tr> <tr style="vertical-align: bottom"> <td style="text-align: left"><div style="display: inline; font-weight: bold;">(In thousands)</div></td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2019</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> </tr> <tr style="vertical-align: bottom"> <td style="font-weight: bold; text-align: center">&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Renewable Products</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Licenses and Royalties</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Grants and Collaborations</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Renewable Products</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Licenses and Royalties</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Grants and Collaborations</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 20%; text-align: left">United States</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,073</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">493</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,566</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,962</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,209</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,171</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Europe</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,854</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">118</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,629</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,601</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,434</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,955</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,500</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,889</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Asia</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,718</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">250</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,968</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">678</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">678</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">South America</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">220</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">220</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">21</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">21</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="padding-bottom: 1pt">Other</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,884</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">118</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,372</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">14,374</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,195</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,955</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,709</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">17,859</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <!-- Field: Page; Sequence: 22; Value: 4 --> <!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Significant Revenue Agreements During the Three Months Ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div></div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">In <div style="display: inline; color: #231F20">connection with significant revenue agreements, the Company recognized the following revenues for the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> months ended </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div><div style="display: inline; color: #231F20">:</div>&nbsp;</div> <div style=" margin: 0pt 0">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="31" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Three Months Ended March 31,</td> </tr> <tr style="vertical-align: bottom"> <td style="text-align: left"><div style="display: inline; font-weight: bold;">(In thousands)</div></td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2019</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> </tr> <tr style="vertical-align: bottom"> <td style="font-weight: bold; text-align: center">&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Renewable Products</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Licenses and Royalties</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Grants and Collaborations</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Renewable Products</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Licenses and Royalties</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Grants and Collaborations</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 20%">Firmenich</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,891</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">498</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">728</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,117</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">207</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">37</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,267</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,511</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Givaudan</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,575</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,575</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,076</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,500</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,576</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">American Sugar Refining</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,494</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,494</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">DSM - related party</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(380</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">396</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,918</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">734</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,652</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-left: 20pt; text-indent: -10pt; white-space: nowrap">Subtotal revenue from significant revenue agreements</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,962</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">118</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,124</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,204</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,283</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,955</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,501</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,739</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">Revenue from all other customers</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,922</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,248</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,170</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,912</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,208</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,120</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 2.5pt; padding-left: 10pt">Total revenue from all customers</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,884</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">118</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,372</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">14,374</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,195</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,955</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,709</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">17,859</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Contract Assets and Liabilities</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">When a contract results in revenue being recognized in excess of the amount the Company has invoiced or has the right to invoice to the customer, a contract asset is recognized. Contract assets are transferred to accounts receivable, net when the rights to the consideration become unconditional.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Contract liabilities consist of payments received from customers, or such consideration that is contractually due, in advance of providing the product or performing services such that control has <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> passed to the customer.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">Trade receivables related to revenue from contracts with customers are included in accounts receivable on the condensed consolidated balance sheets, net of the allowance for doubtful accounts. Trade accounts receivable are recorded at the point of renewable product sale or in accordance with the contractual payment terms for licenses and royalties, and grants and collaborative research and development services for the amount payable by the customer to the Company for sale of goods or the performance of services.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Contract Balances</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The following table provides information about accounts receivable and contract liabilities from contracts with customers:</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">March 31, 2019</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 62%; text-align: left">Accounts receivable, net</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 16%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,968</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 16%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,003</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Accounts receivable - related party, net</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,334</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,349</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Accounts receivable, unbilled - related party</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,021</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Accounts receivable, unbilled, noncurrent - related party</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,203</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,203</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Contract liabilities</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,333</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,236</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left"><div style="display: inline; font-size: 10pt">Contract liabilities, noncurrent<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(1)</div></div></td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,449</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,587</div></td> <td style="text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div>)&nbsp;&nbsp;&nbsp;&nbsp; </div>As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> contract liabilities, noncurrent is presented in Other Noncurrent Liabilities in the condensed consolidated balance sheets because of its insignificance.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <!-- Field: Page; Sequence: 23; Value: 4 --> <!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">Unbilled receivables at the end of the period relate to the Company&#x2019;s right to consideration from DSM for performance fees. The Company&#x2019;s right to cash receipt for these minimum royalty amounts occurs on or before <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2019. </div>From <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> the combination of current and noncurrent unbilled receivables decreased by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.0</div> million as the result of invoices issued to DSM during the period. An <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.0</div> million unbilled accounts receivable was originally due on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2019 </div>but was paid early by DSM. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.6</div> million difference between the original amount due and the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$7.4</div> million cash payment received was recorded as a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.4</div> million reduction of licenses and royalties revenue during the quarter and a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.2</div> million reduction to interest income.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;">Remaining Performance Obligations</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The following table provides information regarding the estimated revenue expected to be recognized in the future related to performance obligations that are unsatisfied (or partially unsatisfied) based on the Company's existing agreements with customers as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019.</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold; text-align: left">(In thousands)</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">As of March 31, 2019</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 72%; text-align: left">Remaining 2019</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 25%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,920</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2020</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">38,508</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">2021</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,172</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">2022 and thereafter</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 2.5pt">Total from all customers</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">93,600</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In accordance with the disclosure provisions of ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606,</div> the table above excludes estimated future revenues for performance obligations that are part of a contract that has an original expected duration of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> year or less or a performance obligation with variable consideration that is recognized using the sales-based royalty exception for licenses of intellectual property. Additionally, approximately <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$17.6</div> million of estimated future revenue is excluded from the table above, as that amount represents constrained variable consideration.</div></div> 0.0001 0.0001 250000000 250000000 77210681 76564829 77210681 76564829 8000 8000 -65279000 -92939000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">March 31, 2019</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 62%; text-align: left">Accounts receivable, net</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 16%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,968</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 16%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,003</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Accounts receivable - related party, net</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,334</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,349</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Accounts receivable, unbilled - related party</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,021</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Accounts receivable, unbilled, noncurrent - related party</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,203</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,203</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Contract liabilities</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,333</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,236</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left"><div style="display: inline; font-size: 10pt">Contract liabilities, noncurrent<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(1)</div></div></td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,449</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,587</div></td> <td style="text-align: left">&nbsp;</td> </tr> </table></div> 600000 8021000 8021000 1203000 1203000 1203000 1203000 8000000 8333000 8236000 1449000 1587000 400000 17707000 5315000 63799000 41240000 32512000 8531000 41043000 -803000 -803000 3479008 1122460 2500000 1767632 13500000 5000000 10000000 9700000 53300000 4700000 53300000 4700000 63600000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.</div> Debt</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Net carrying amounts of debt are as follows:</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; margin-left: 22.5pt; min-width: 700px;"> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">March 31, 2019</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">December 31, 2018</td> </tr> <tr style="vertical-align: bottom"> <td style="font-weight: bold; text-align: left">(In thousands)</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Principal</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Unamortized Debt (Discount) Premium</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Change in Fair Value</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Net Balance</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Principal</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Unamortized Debt (Discount) Premium</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Change in Fair Value</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Net Balance</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-style: italic; text-align: left">Convertible notes payable</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 28%; text-align: left; padding-left: 10pt">6% convertible notes due 2021</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60,000</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">48</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60,048</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60,000</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,082</div></td> <td style="width: 1%; text-align: left">)</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,918</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-left: 10pt">2015 Rule 144A convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">37,887</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(358</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">37,529</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">37,887</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,413</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">35,474</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-left: 10pt">2014 Rule 144A convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,004</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(289</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,715</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,004</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(867</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,137</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt; padding-left: 10pt">August 2013 financing convertible note</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,863</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(596</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,267</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,415</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(70</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,345</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">126,754</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,243</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">48</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">125,559</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">126,306</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,350</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,082</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">120,874</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-style: italic; text-align: left">Related party convertible notes payable</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-left: 10pt">2014 Rule 144A convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,705</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(346</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,359</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,705</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,038</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,667</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-style: italic; text-align: left">Loans payable and credit facilities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-left: 10pt">GACP secured term loan facility</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">36,000</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,208</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">34,792</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">36,000</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,349</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">34,651</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-left: 10pt">Ginkgo note</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,000</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,832</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,168</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,000</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(4,047</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,953</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt; padding-left: 10pt">Other loans payable</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,813</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,011</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,802</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,910</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,047</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,863</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">52,813</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,051</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">46,762</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">52,910</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,443</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">46,467</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-style: italic; text-align: left">Related party loans payable</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt; padding-left: 10pt">DSM note</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(5,853</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19,147</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,311</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,689</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 2.5pt">Total debt</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">229,272</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(13,493</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">)</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">48</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">215,827</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">228,921</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(17,142</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">)</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,082</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">)</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">209,697</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">Less: current portion</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(153,752</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(147,677</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="padding-bottom: 1pt">Long-term debt, net of current portion</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">62,075</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">62,020</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> convertible notes due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> have been classified as current in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018 </div>balance sheets, due to certain events subsequent to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 31, 2019 </div>but prior to the issuance of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 31, 2019 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018 </div>financial statements. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,</div> "Subsequent Events" for additional information.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 14, 2019, </div>Wolverine Flagship Fund Trading Limited (Wolverine) agreed to waive payment of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2013 </div>Financing Convertible Note held by Wolverine at its <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 15, 2019 </div>maturity until <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 15, 2019 </div>in exchange for a fee, payable on or prior to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 15, 2019, </div>of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.6</div> million. The Company concluded that the term extension represented a debt modification, and the fee was accounted for as additional debt discount to be amortized over the remaining term. Effective <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 15, 2019, </div>the due date of the waiver fee was extended to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 13, 2019 </div>and will bear interest at a rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1.75%</div> per month, compounded, from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 16, 2019 </div>to the date of payment. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,</div> &#x201c;Subsequent Events&#x201d; for additional information.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</div> <!-- Field: Page; Sequence: 19; Value: 4 --> <!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-weight: bold;">Future Minimum Payments</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Future minimum payments under the Company's debt agreements as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> are as follows:</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; margin-left: 22.5pt; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt; white-space: nowrap">(In thousands)</td> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt; white-space: nowrap">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid; white-space: nowrap">Convertible<br /> Notes</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid; white-space: nowrap">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid; white-space: nowrap">Loans<br /> Payable<br /> and Credit<br /> Facilities</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid; white-space: nowrap">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid; white-space: nowrap">Related<br /> Party<br /> Convertible<br /> Notes</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid; white-space: nowrap">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid; white-space: nowrap">Related<br /> Party Loans<br /> Payable and<br /> Credit<br /> Facilities</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid; white-space: nowrap">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid; white-space: nowrap">Total</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 45%; font-size: 10pt">2019 (remaining nine months)</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 8%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">139,303</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 8%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,689</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 8%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,618</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 8%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,875</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 8%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">176,485</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">2020</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,113</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,500</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,613</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">2021</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">34,776</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28,146</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">62,922</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">2022</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,450</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,450</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">2023</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">399</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">399</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; padding-bottom: 1pt">Thereafter</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,268</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,268</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Total future minimum payments</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">139,303</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">70,695</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,618</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">32,521</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">268,137</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Less: amount representing interest</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(12,303</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(17,883</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(913</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(7,521</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(38,620</div></td> <td style="font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt">Less: future conversion of accrued interest to principal</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(245</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(245</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Present value of minimum debt payments</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">126,755</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">52,812</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,705</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">229,272</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt">Less: current portion of debt principal</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(126,755</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(4,513</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(24,705</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left; border-bottom: Black 1pt solid">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(155,973</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-bottom: 2.5pt">Noncurrent portion of debt principal</td> <td style="font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">48,299</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">73,299</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> </tr> </table> </div></div> 0.09 0.12 0.0025 60000000 71000000 60000000 60000000 37887000 37887000 24004000 24004000 4863000 4415000 126754000 126306000 24705000 24705000 36000000 36000000 12000000 12000000 4813000 4910000 52813000 52910000 25000000 25000000 229272000 228921000 60000000 32500000 8000000 8500000 8000000 19000000 3000000 3000000 2000000 68300000 68300000 3000000 2000000 2018000000 10435000 12500000 155800000 1000000 500000 0.06 0.0175 0.0475 0 0.125 0.125 0.12 0.125 0.105 0.06 0.18 0.05 0.1 0.12 0.12 0.105 0.12 6400000 3200000 13500000 358000 2413000 289000 867000 596000 70000 1243000 3350000 346000 1038000 1208000 1349000 3832000 4047000 1011000 1047000 6051000 6443000 5853000 6311000 13493000 17142000 155800000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">March 31, 2019</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 64%; text-align: left">Prepayments, advances and deposits</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,310</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,644</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Recoverable taxes from Brazilian government entities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">956</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">631</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="padding-bottom: 1pt">Other</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,949</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,291</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="padding-bottom: 0pt; padding-left: 10pt">Total prepaid expenses and other current assets</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,215</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,566</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> 1449000 1587000 6582000 6582000 145000 2465000 800000 1600000 848000 1561000 3798000 42796000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="31" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Three Months Ended March 31,</td> </tr> <tr style="vertical-align: bottom"> <td style="text-align: left"><div style="display: inline; font-weight: bold;">(In thousands)</div></td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2019</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> </tr> <tr style="vertical-align: bottom"> <td style="font-weight: bold; text-align: center">&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Renewable Products</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Licenses and Royalties</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Grants and Collaborations</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Renewable Products</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Licenses and Royalties</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Grants and Collaborations</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 20%; text-align: left">United States</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,073</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">493</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,566</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,962</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,209</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,171</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Europe</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,854</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">118</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,629</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,601</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,434</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,955</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,500</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,889</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Asia</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,718</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">250</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,968</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">678</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">678</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">South America</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">220</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">220</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">21</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">21</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="padding-bottom: 1pt">Other</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,884</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">118</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,372</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">14,374</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,195</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,955</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,709</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">17,859</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11.</div> Stock-based Compensation</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company&#x2019;s stock option activity and related information for the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> months ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> was as follows:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="text-align: center">&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Quantity of Stock Options</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Weighted-<br /> average <br /> Exercise <br /> Price</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Weighted-average<br /> Remaining <br /> Contractual <br /> Life, in Years</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Aggregate<br /> Intrinsic <br /> Value, in Thousands</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 48%">Outstanding - December 31, 2018</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,390,270</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11.55</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8.5</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Granted</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">104,452</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.73</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Exercised</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,612</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3.68</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Forfeited or expired</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(63,726</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">14.27</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Outstanding - March 31, 2019</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,427,384</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11.39</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8.3</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Vested or expected to vest after March 31, 2019</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,874,155</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12.10</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8.3</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Exercisable at March 31, 2019</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">977,466</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">39.20</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.8</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The Company&#x2019;s restricted stock units (RSUs) activity and related information for the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> months ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> was as follows:</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Quantity of Restricted Stock Units</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Weighted-average Grant-date Fair Value</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Weighted-average Remaining Contractual Life, in Years</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 55%">Outstanding - December 31, 2018</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,294,803</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.50</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1.7</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Awarded</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">493,790</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.65</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>RSUs released</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(192,795</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6.55</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>RSUs forfeited</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(102,219</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.61</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Outstanding - March 31, 2019</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,493,579</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.38</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1.5</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Vested or expected to vest after March 31, 2019</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,153,107</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.39</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1.5</div></td> <td style="text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Stock-based compensation expense related to employee and non-employee options, RSUs and ESPP during the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> months ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> was allocated to research and development expense and sales, general and administrative expense as follows:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="7" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Three Months Ended March 31,</td> </tr> <tr style="vertical-align: bottom"> <td style="font-weight: bold">(In thousands)</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2019</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 70%; text-align: left">Research and development</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">663</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">363</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">Sales, general and administrative</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,789</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">915</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 2.5pt; padding-left: 10pt">Total stock-based compensation expense</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,452</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,278</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> there was unrecognized compensation expense of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$31.1</div> million related to stock options and RSUs. The Company expects to recognize this expense over a weighted-average period of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3.0</div> years.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;">Evergreen Shares for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> Equity Incentive Plan and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> Employee Stock Purchase Plan</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 2019, </div>the Company's Board of Directors (the Board) approved increases to the number of shares available for issuance under the Company's <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> Equity Incentive Plan (the Equity Plan) and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> Employee Stock Purchase Plan (the Purchase Plan). These shares in connection with the Equity Plan represented an automatic annual increase in the number of shares available for grant and issuance under the Equity Plan of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,828,241</div> shares. This increase is equal to approximately <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.0%</div> of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">76,564,829</div> total outstanding shares of the Company&#x2019;s common stock as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018.</div> This automatic increase was effective as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2019. </div>These shares in connection with the Purchase Plan represented an automatic annual increase in the number of shares reserved for issuance under the Purchase Plan of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">383,824</div> shares. This increase is equal to approximately <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">0.5%</div> of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">76,564,829</div> total outstanding shares of the Company&#x2019;s common stock as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018.</div> This automatic increase was effective as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2019.</div></div></div> -1778000 24359000 23667000 19147000 18689000 -0.82 -1.67 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7.</div> Loss Per Share</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">For the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> months ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> basic loss per share was the same as diluted loss per share, because the inclusion of all potentially dilutive securities outstanding was antidilutive.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company follows the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div>-class method when computing net loss per common share when shares are issued that meet the definition of participating securities. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div>-class method requires income available to common stockholders for the period to be allocated between common stock and participating securities based upon their respective rights to receive dividends as if all income for the period had been distributed. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div>-class method also requires losses for the period to be allocated between common stock and participating securities based on their respective rights if the participating security contractually participates in losses. The Company&#x2019;s convertible preferred stock are participating securities as they contractually entitle the holders of such shares to participate in dividends and contractually require the holders of such shares to participate in the Company&#x2019;s losses.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The following table presents the calculation of basic and diluted loss per share:</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap">&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="7" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Three Months Ended March 31,</td> </tr> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold"><div style="display: inline; text-decoration: underline;">(In thousands, except shares and per share amounts)</div></td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2019</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> </tr> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-style: italic">Numerator:</td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 70%; text-align: left">Net loss attributable to Amyris, Inc.</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(66,243</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">)</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(92,802</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">Less: losses allocated to participating securities</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,430</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,504</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 2.25pt">Net loss attributable to Amyris, Inc. common stockholders</td> <td style="padding-bottom: 2.25pt">&nbsp;</td> <td style="border-bottom: Black 2.25pt double; text-align: left">$</td> <td style="border-bottom: Black 2.25pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(63,813</div></td> <td style="white-space: nowrap; border-bottom: Black 2.25pt double; text-align: left">)</td> <td style="padding-bottom: 2.25pt">&nbsp;</td> <td style="border-bottom: Black 2.25pt double; text-align: left">$</td> <td style="border-bottom: Black 2.25pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(85,298</div></td> <td style="white-space: nowrap; border-bottom: Black 2.25pt double; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-style: italic">Denominator:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.25pt">Weighted-average shares of common stock outstanding used in computing loss per share of common stock, basic and diluted</td> <td style="padding-bottom: 2.25pt">&nbsp;</td> <td style="border-bottom: Black 2.25pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.25pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">77,512,059</div></td> <td style="white-space: nowrap; border-bottom: Black 2.25pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.25pt">&nbsp;</td> <td style="border-bottom: Black 2.25pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.25pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">51,200,922</div></td> <td style="white-space: nowrap; border-bottom: Black 2.25pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 2.25pt">Loss per share attributable to common stockholders, basic and diluted</td> <td style="padding-bottom: 2.25pt">&nbsp;</td> <td style="border-bottom: Black 2.25pt double; text-align: left">$</td> <td style="border-bottom: Black 2.25pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(0.82</div></td> <td style="white-space: nowrap; border-bottom: Black 2.25pt double; text-align: left">)</td> <td style="padding-bottom: 2.25pt">&nbsp;</td> <td style="border-bottom: Black 2.25pt double; text-align: left">$</td> <td style="border-bottom: Black 2.25pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1.67</div></td> <td style="white-space: nowrap; border-bottom: Black 2.25pt double; text-align: left">)</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The following outstanding shares of potentially dilutive securities were excluded from the computation of diluted loss per share of common stock because including them would have been antidilutive:</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="7" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Three Months Ended March 31,</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2019</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 70%; text-align: left">Period-end stock options to purchase common stock</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,427,384</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,365,447</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left"><div style="display: inline; font-size: 10pt">Convertible promissory notes<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(1)</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,699,607</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,347,364</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Period-end common stock warrants</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">26,411,761</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29,759,452</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Period-end restricted stock units</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,493,579</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">706,697</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt">Period-end preferred stock</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,955,732</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,504,212</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt">Total potentially dilutive securities excluded from computation of diluted loss per share</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">52,988,063</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">44,683,172</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 6.5in 0pt 0; text-align: left">______________</div> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; min-width: 700px;"> <tr style="vertical-align: top"> <td style="width: 0"></td> <td style="width: 14pt"><div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div>)</div></td> <td style="text-align: justify">The potentially dilutive effect of convertible promissory notes was computed based on conversion ratios in effect as of the respective period end dates. A portion of the convertible promissory notes issued carries a provision for a reduction in conversion price under certain circumstances, which could potentially increase the dilutive shares outstanding. Another portion of the convertible promissory notes issued carries a provision for an increase in the conversion rate under certain circumstances, which could also potentially increase the dilutive shares outstanding.</td> </tr> </table></div> -70000 -68000 5285000 9220000 31100000 P3Y 0.5 0.5 27900000 1500000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold">In thousands</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 77%">Fair value at December 31, 2018</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 20%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,918</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">Change in fair value</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,130</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="padding-bottom: 2.5pt">Fair value at March 31, 2019</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60,048</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> -2130000 -2039000 -2039000 39513000 1524000 41037000 57918000 60048000 41272000 1524000 42796000 3798000 3798000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold">(In thousands)</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Equity-related Derivative Liability</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Debt-related Derivative Liability</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total Derivative Liability</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 61%">Balance at December 31, 2018</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">41,272</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,524</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,796</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Derecognition upon adoption of ASU 2017-11</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(39,513</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,524</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(41,037</div></td> <td style="text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt">Change in fair value of derivative liabilities</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,039</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,039</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="padding-bottom: 2.5pt">Balance at March 31, 2019</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,798</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,798</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> 545000 452000 93000 568000 1000 199000 368000 23000 5300000 5000000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3.</div> Fair Value Measurement</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 22.5pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Assets and Liabilities Measured and Recorded at Fair Value on a Recurring Basis</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">The following tables summarize assets and liabilities measured at fair value, and the respective fair value by input classification level within the fair value hierarchy:</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; margin-left: 0.25in; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold">(In thousands)</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">March 31, 2019</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">December 31, 2018</td> </tr> <tr style="vertical-align: bottom"> <td style="text-align: center">&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Level&nbsp;1</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Level 2</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Level&nbsp;3</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Total</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Level&nbsp;1</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Level 2</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Level&nbsp;3</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Total</td> </tr> <tr style="vertical-align: bottom"> <td style="font-weight: bold">Liabilities</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; width: 28%">6% Convertible Notes Due 2021</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60,048</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60,048</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,918</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,918</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt; padding-left: 10pt; text-indent: -10pt">Freestanding derivative instruments in connection with the issuance of equity instruments</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,798</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,798</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,796</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,796</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 2.5pt; padding-left: 20pt; text-indent: -10pt">Total liabilities measured and recorded at fair value</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">63,846</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">63,846</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100,714</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100,714</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">There were <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> transfers between levels during the periods presented.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</div> <!-- Field: Page; Sequence: 17; Value: 4 --> <!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">The Company issued <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$60.0</div> million of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 10, 2018 </div>and elected the fair value option of accounting for this instrument. At <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> outstanding principal was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$60.0</div> million, and the fair value was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$60.0</div> million, which was measured using a binomial lattice model and assuming a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23.8%</div> discount yield, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">45%</div> equity volatility, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50%</div> / <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50%</div> probability of principal repayment in cash / stock, and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5%</div> probability of change in control. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,</div> &#x201c;Debt&#x201d; for further information related to this debt instrument. For the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> months ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> the Company recorded a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.1</div> million loss from change in fair value of debt in connection with the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021,</div> as follows:</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold">In thousands</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 77%">Fair value at December 31, 2018</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 20%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,918</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">Change in fair value</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,130</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="padding-bottom: 2.5pt">Fair value at March 31, 2019</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60,048</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"><div style="display: inline; font-style: italic;">Derivative Liabilities Recognized in Connection with the Issuance of Debt and Equity Instruments</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">The following table provides a reconciliation of the beginning and ending balances for the Company's derivative liabilities recognized in connection with the issuance of debt and equity instruments, measured at fair value using significant unobservable inputs (Level <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div>):</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold">(In thousands)</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Equity-related Derivative Liability</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Debt-related Derivative Liability</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total Derivative Liability</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 61%">Balance at December 31, 2018</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">41,272</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,524</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,796</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Derecognition upon adoption of ASU 2017-11</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(39,513</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,524</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(41,037</div></td> <td style="text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt">Change in fair value of derivative liabilities</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,039</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,039</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="padding-bottom: 2.5pt">Balance at March 31, 2019</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,798</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,798</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0">As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> the remaining derivative liabilities are in connection with the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018 </div>Securities Purchase Agreement with DSM. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> &#x201c;Revenue Recognition&#x201d; in Part II, Item <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8</div> of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div>-K/A. This make-whole provision is effectively marked to market through the condensed consolidated statements of operations, based on the Company&#x2019;s closing stock price at each reporting period until converted into common stock or cash settled. The fair value of these instruments is directly affected by the volatility of the Company&#x2019;s stock price between each reporting period or conversion date, if settled during the reporting period.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Assets and Liabilities Recorded at Carrying Value</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"><div style="display: inline; font-style: italic;">Financial Assets and Liabilities</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0">The carrying amounts of certain financial instruments, such as cash equivalents, accounts receivable, accounts payable and accrued liabilities, approximate fair value due to their relatively short maturities and low market interest rates, if applicable. Loans payable, credit facilities and convertible notes are recorded at carrying value (except for the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021,</div> which are recorded at fair value), which is representative of fair value at the date of acquisition. For loans payable and credit facilities recorded at carrying value, the Company estimates fair value using observable market-based inputs (Level <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div>); for convertible notes, the Company estimates fair value based on rates currently offered for instruments with similar maturities and terms (Level <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div>). The carrying amount (the total amount of net debt presented on the balance sheet) of the Company's debt at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> excluding the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes that the Company records at fair value, was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$155.8</div> million. The fair value of such debt at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$155.8</div> million, and was determined by (i) discounting expected cash flows using current market discount rates estimated for certain of the debt instruments and (ii) using <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">third</div>-party fair value estimates for the remaining debt instruments.</div></div> 108000 -243000 -2039000 -58357000 -1000 -1035000 438000 -66243000 -92802000 4286000 4286000 1834000 -108000 -5048000 -74000 6245000 -11120000 -8021000 -93000 108000 4264000 -41000000 -1196000 -420000 200000 12534000 9978000 3099000 1815000 7094000 3853000 5797000 5253000 8486000 9693000 2451000 3901000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; margin-left: 40.5pt; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold"><div style="display: inline; text-decoration: underline;">Amounts in thousands</div></td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Three Months Ended March 31, 2019</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 87%; text-align: left">Cash paid for operating lease liabilities</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,305</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Right-of-use assets obtained in exchange for new operating lease obligations<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(1)</div></td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">30,472</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Weighted-average remaining lease term (in years)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2.7</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Weighted-average discount rate</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18.0</div></td> <td style="text-align: left">%</td> </tr> </table></div> 39522000 3034000 7398000 7226000 9109000 12755000 9793000 P1Y P5Y 24900000 337347000 339744000 105147000 127925000 235704000 211736000 63846000 63846000 100714000 100714000 8000000 8000000 8000000 8500000 16000000 19000000 8000000 12500000 215827000 5000000 60048000 57918000 37529000 35474000 23715000 23137000 4267000 4345 125559000 120874000 24359000 23667000 34792000 34651000 8168000 7953000 3802000 3863000 46762000 46467000 19147000 18689000 209697000 129393000 124010000 60000000 60048000 57918000 60048000 60048000 57918000 57918000 0.238 0.45 0.5 0.5 0.05 42928000 43331000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8.</div> Commitments and Contingencies</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Contingencies</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt; color: #231F20"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0; color: #231F20">The Company has levied indirect taxes on sugarcane-based biodiesel sales that took place several years ago by Amyris Brasil Ltda. (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,</div> &#x201c;Divestiture&#x201d; in Part II, Item <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8</div> of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> Form <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div>-K/A) to customers in Brazil, based on advice from external legal counsel. In the absence of definitive rulings from the Brazilian tax authorities on the appropriate indirect tax rate to be applied to such product sales, the actual indirect rate to be applied to such sales could differ from the rate the Company levied.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt; color: #231F20"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <!-- Field: Page; Sequence: 21; Value: 4 --> <!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt; color: #231F20"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0; color: #231F20">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 3, 2019, </div>a securities class action complaint was filed against Amyris and our CEO, John G. Melo, and former CFO (and current Chief Business Officer), Kathleen Valiasek, in the U.S. District Court for the Northern District of California. The complaint seeks unspecified damages on behalf of a purported class that would comprise all persons and entities that purchased or otherwise acquired our securities between <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 15, 2018 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 19, 2019. </div>The complaint alleges securities law violations based on statements and omissions made by the Company during such period. Subsequent to the filing of the securities class action complaint described above, on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 21, 2019 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 1, 2019, </div>respectively, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> separate purported shareholder derivative complaints were filed in the U.S. District Court for the Northern District of California (Bonner v. Doerr, et al., Case <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">No.</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4:19</div>-cv-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">03621</div> and Carlson v. Doerr, et al., Case <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">No.</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4:19</div>-cv-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">06230</div>) based on similar allegations to those made in the securities class action complaint described above. The derivative complaints name Amyris, Inc. as a nominal defendant and name a number of the Company&#x2019;s current and former officers and directors as additional defendants. The lawsuits seek to recover, on the Company's behalf, unspecified damages purportedly sustained by the Company in connection with allegedly misleading statements and omissions made in connection with the Company&#x2019;s securities filings. The derivative complaints also seek a series of changes to the Company&#x2019;s corporate governance policies, restitution to the Company from the individual defendants, and an award of attorneys&#x2019; fees. These cases are in the initial pleadings stage. We believe the complaints lack merit, and intend to defend ourselves vigorously. Given the early stage of these proceedings, it is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> yet possible to reliably determine any potential liability that could result from these matters.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt; color: #231F20"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt; color: #231F20">The Company is subject to disputes and claims that arise or have arisen in the ordinary course of business and that have <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> resulted in legal proceedings or have <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> been fully adjudicated. Such matters that <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>arise in the ordinary course of business are subject to many uncertainties and outcomes are <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> predictable with reasonable assurance and therefore an estimate of all the reasonably possible losses cannot be determined at this time. Therefore, if <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> or more of these legal disputes or claims resulted in settlements or legal proceedings that were resolved against the Company for amounts in excess of management's expectations, the Company's consolidated financial statements for the relevant reporting period could be materially adversely affected.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Other Matters</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Certain conditions <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>exist as of the date the condensed consolidated financial statements are issued, which <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>result in a loss to the Company but will only be recorded when <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> or more future events occur or fail to occur. The Company's management assesses such contingent liabilities, and such assessment inherently involves an exercise of judgement. In assessing loss contingencies related to legal proceedings that are pending against and by the Company or unasserted claims that <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>result in such proceedings, the Company's management evaluates the perceived merits of any legal proceedings or unasserted claims as well as the perceived merits of the amount of relief sought or expected to be sought.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">If the assessment of a contingency indicates that it is probable that a material loss has been incurred and the amount of the liability can be estimated, then the estimated liability would be accrued in the Company's financial statements. If the assessment indicates that a potential material loss contingency is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> probable but is reasonably possible, or is probable but cannot be reasonably estimated, then the nature of the contingent liability, together with an estimate of the range of possible loss if determinable and material would be disclosed. Loss contingencies considered to be remote by management are generally <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> disclosed unless they involve guarantees, in which case the guarantee would be disclosed.</div></div> 937000 937000 -222000 -6694000 -3046000 -1584000 -36980000 -25169000 -66243000 -92802000 -66243000 -92802000 -63813000 -85298000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><div style="display: inline; font-weight: bold;">Accounting Standards or Updates Recently Adopted</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">In the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> months ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> the Company adopted these accounting standards or updates:</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Leases</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 2016, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">No.</div>&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">02,</div> <div style="display: inline; font-style: italic;">Leases (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">842</div>).</div> The standard requires the recognition of lease liabilities and right-of-use (ROU) assets on the balance sheet arising from lease transactions at the lease commencement date and the disclosure of key information about leasing arrangements. In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2018, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,</div> <div style="display: inline; font-style: italic;">Leases (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">842</div>) Targeted Improvements</div>, which provides an additional transition method in which the lease standard is applied at the adoption date and recognized as a cumulative-effect adjustment to retained earnings without adjustment to comparative periods (collectively Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">842</div>). The amendment has the same effective date and transition requirements as the lease standard.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The Company adopted this standard on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2019 </div>using the modified retrospective approach and elected the package of practical expedients permitted under transition guidance, which allowed the Company to carry forward its historical assessments of: (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div>) whether contracts are or contain leases, (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div>) lease classification and (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div>) initial direct costs, where applicable. The Company did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> elect the practical expedient allowing the use-of-hindsight which would require the Company to reassess the lease term of its leases based on all facts and circumstances through the effective date and did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> elect the practical expedient pertaining to land easements as this is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> applicable to the Company&#x2019;s current contracts. The Company elected the post-transition practical expedient to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> separate lease components from non-lease components for all leases of manufacturing equipment. The Company also elected a policy of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> recording leases on its condensed consolidated balance sheets when the leases have a term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12</div> months or less and the Company is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> reasonably certain to elect an option to purchase the leased asset.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The adoption of this standard had the effect of increasing assets and liabilities on the condensed consolidated balance sheet by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$25.7</div> million, but did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> have a material impact on the condensed consolidated statements of operations or cash flows.&nbsp; The most significant impact relates to (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div>) the recognition of new ROU assets and lease liabilities on the balance sheet for operating leases; and (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div>) providing significant new disclosures about leasing activities.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">Upon adoption, the Company recognized operating lease liabilities of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$33.6</div> million, based on the present value of the remaining minimum rental payments under current leasing standards for existing operating leases.&nbsp;The Company also recognized ROU assets of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$29.7</div> million, which represents the operating lease liability, adjusted for prepaid expenses and deferred rent. The difference between the operating lease ROU assets and lease liabilities reflects the net of advanced rent payments and deferred rent balances that were derecognized at the time of adoption.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Financial Instruments with "Down Round" Features</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2017, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,</div>&nbsp;<div style="display: inline; font-style: italic;">Earnings Per Share (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">260</div>); Distinguishing Liabilities from Equity (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">480</div>); Derivatives and Hedging (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">815</div>): Accounting for Certain Financial Instruments with Down Round Features</div>. The amendments of this ASU update the classification analysis of certain equity-linked financial instruments, or embedded features, with down round features, as well as clarify existing disclosure requirements for equity-classified instruments. When determining whether certain financial instruments should be classified as liabilities or equity instruments, a down round feature <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> longer precludes equity classification when assessing whether the instrument is indexed to an entity&#x2019;s own stock. The accounting standard update became effective in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> quarter of fiscal year <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> and the Company adopted the standard using a modified retrospective approach. Since the adoption of ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11</div> would have classified the warrants effected as equity at inception, the cumulative-effect adjustment should (i) record the issuance date value of the warrants as if they had been equity classified at the issuance date, (ii) reverse the effects of changes in the fair value of the warrants that had been recorded in the statement of operations of each period, and (iii) eliminate the derivative liabilities from the balance sheet. Upon adoption, the Company (i) recorded an increase of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$32.5</div> million to additional paid-in capital, (ii) recorded a decrease to accumulated deficit of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.5</div> million and (iii) decreased the warrant liability by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$41.0</div> million.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><div style="display: inline; font-weight: bold;">Recent Accounting Standards or Updates <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">Not</div> Yet Effective</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-style: italic;">&nbsp;</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Fair Value Measurement</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2018, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,</div> <div style="display: inline; font-style: italic;">Fair Value Measurement (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">820</div>): Disclosure Framework&#x2014;Changes to the Disclosure Requirements for Fair Value Measurement</div>, which amends ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">820,</div> <div style="display: inline; font-style: italic;">Fair Value Measurement</div>. ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div> modifies the disclosure requirements for fair value measurements by removing, modifying or adding certain disclosures. The accounting standard update will be effective beginning in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> quarter of fiscal <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2020,</div> with removed and modified disclosures to be adopted on a retrospective basis, and new disclosures to be adopted on a prospective basis. The Company is in the initial stages of evaluating the impact of the standard on its condensed consolidated financial statements.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Collaborative Revenue Arrangements</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,</div> <div style="display: inline; font-style: italic;">Clarifying the Interaction between Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">808</div> and Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606</div></div>, that clarifies the interaction between the guidance for certain collaborative arrangements and Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606,</div> the new revenue recognition standard. A collaborative arrangement is a contractual arrangement under which <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> or more parties actively participate in a joint operating activity and are exposed to significant risks and rewards that depend on the activity&#x2019;s commercial success. The ASU provides guidance on how to assess whether certain transactions between collaborative arrangement participants should be accounted for within the revenue recognition standard. The accounting standard update will be effective beginning in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> quarter of fiscal year <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2020</div> retroactively. The Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> believe that the impact of the new standard on its condensed consolidated financial statements will be material.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Credit Losses</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 2016, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,</div> <div style="display: inline; font-style: italic;">Financial Instruments&#x2014;Credit Losses (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">326</div>), Measurement of Credit Losses on Financial Instruments</div>. ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div> requires entities to measure all expected credit losses for most financial assets held at the reporting date based on an expected loss model which includes historical experience, current conditions, and reasonable and supportable forecasts. Entities will now use forward-looking information to better form their credit loss estimates. ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div> also requires enhanced disclosures to help financial statement users better understand significant estimates and judgments used in estimating credit losses, as well as the credit quality and underwriting standards of an entity's portfolio. ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div> will become effective for the Company beginning in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> quarter of fiscal year <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2020.</div> The Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> believe that the impact of the new standard on its condensed consolidated financial statements will be material.</div></div></div></div></div></div> -16818000 -69421000 -49425000 -23381000 2800000 1800000 33600000 29729000 10972000 18757000 5305000 29700000 27645000 800000 0.18 P2Y255D 3949000 4291000 1117000 1207000 5548000 7958000 964000 -137000 964000 964000 -137000 -137000 1054000 3284000 16920000 23192000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; margin-left: 49.5pt; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold; text-align: left"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">March 31, 2019</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 64%; text-align: left">Contract termination fees, net of current portion</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,207</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,715</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Liability for unrecognized tax benefit</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,582</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,582</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Contract liability, net of current portion (Note 9)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,449</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,587</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Deferred rent, net of current portion<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(1)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,440</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="padding-bottom: 1pt">Other</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">682</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">868</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt">Total other noncurrent liabilities</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,920</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,192</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> -115000 692000 9000 66000 9000000 3000000 0.0001 0.0001 5000000 5000000 14656 14656 14656 14656 8215000 10566000 3310000 5644000 7400000 20000000 23200000 5800000 5000000 484000 2800000 1900000 92000 13000 81000 0 1000 133000 45874000 43713000 39951000 39922000 10138000 9987000 3279000 3016000 1460000 1749000 100702000 98387000 21558000 19756000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">March 31, 2019</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 64%; text-align: left">Machinery and equipment</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">45,874</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">43,713</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Leasehold improvements</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">39,951</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">39,922</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Computers and software</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,138</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,987</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Furniture and office equipment, vehicles and land</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,279</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,016</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt">Construction in progress</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,460</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,749</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-left: 10pt">Total property, plant and equipment, gross</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100,702</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">98,387</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt">Less: accumulated depreciation and amortization</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(79,144</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(78,631</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt; padding-left: 10pt">Property, plant and equipment, net</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">21,558</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19,756</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> 2500000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10.</div> Related Party Transactions</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 23pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Related Party Debt</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">See <div style="display: inline; color: #231F20">Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,</div> "Debt" above for related party debt </div>as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018.</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Related Party Accounts Receivable and Unbilled Receivables</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Related party accounts receivable and unbilled receivables as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> were as follows:</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold">(In thousands)</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">March 31, 2019</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid">December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Accounts receivable:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 64%; padding-left: 10pt">DSM</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,334</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,071</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="padding-left: 10pt">Novvi</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">188</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="padding-bottom: 1pt; padding-left: 10pt">Total</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">90</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,334</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,349</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Accounts receivable, unbilled, current:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="padding-left: 10pt">DSM</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,021</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Accounts receivable, unbilled, noncurrent:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="padding-left: 10pt">DSM</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,203</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,203</div></td> <td style="text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 23pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Related Party Joint Ventures</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company holds a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50%</div> interest in the Aprinnova joint venture for business-to-business sales&nbsp;of cosmetic ingredients. This joint venture is consolidated in the accompanying condensed consolidated financial statements.</div></div> 37900000 134000 400000 577000 6534000 17839000 17825000 623000 741000 2454000 960000 960000 959000 3111000 3063000 -1579129000 -8500000 -1521417000 11884000 5195000 118000 7955000 2372000 4709000 14374000 17859000 7073000 493000 7566000 1962000 1209000 3171000 2854000 118000 1629000 4601000 2434000 7955000 3500000 13889000 1718000 250000 1968000 678000 678000 220000 220000 21000 21000 19000 19000 100000 100000 11884000 5195000 7955000 4709000 17859000 1891000 498000 728000 3117000 207000 37000 1267000 1511000 1575000 1575000 1076000 1500000 2576000 1494000 1494000 2000 -380000 396000 18000 7918000 734000 8652000 4962000 118000 1124000 6204000 1283000 7955000 3501000 12739000 6922000 1248000 8170000 3912000 1208000 5120000 5195000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-weight: bold;">Revenue Recognition</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The Company recognizes revenue from the sale of renewable products, licenses of and royalties from intellectual property, and grants and collaborative research and development services. Revenue is measured based on the consideration specified in a contract with a customer and recognized when, or as, the Company satisfies a performance obligation by transferring control over a product or service to a customer. The Company generally does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> incur costs to obtain new contracts. The costs to fulfill a contract are expensed as incurred.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The Company accounts for a contract when it has approval and commitment to perform from both parties, the rights of the parties are identified, payment terms are established, the contract has commercial substance and collectability of the consideration is probable. Changes to contracts are assessed for whether they represent a modification or should be accounted for as a new contract. The Company considers the following indicators among others when determining whether it is acting as a principal in the transaction and recording revenue on a gross basis: (i) the Company is primarily responsible for fulfilling the promise to provide the specified goods or service, (ii) the Company has inventory risk before the specified good or service has been transferred to a customer or after transfer of control to the customer and (iii) the Company has discretion in establishing the price for the specified good or service. If a transaction does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> meet the Company's indicators of being a principal in the transaction, then the Company is acting as an agent in the transaction and the associated revenues are recognized on a net basis.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The Company&#x2019;s significant contracts and contractual terms with its customers are presented in Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> "Revenue Recognition" in Part II, Item <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8</div> of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> Form <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div>-K/A.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The Company recognizes revenue when control has passed to the customer. The following indicators are evaluated in determining when control has passed to the customer: (i) the Company has a right to payment for the product or service, (ii) the customer has legal title to the product, (iii) the Company has transferred physical possession of the product to the customer, (iv) the customer has the significant risk and rewards of ownership of the product and (v) the customer has accepted the product. The Company&#x2019;s renewable products are delivered to customers from the Company&#x2019;s facilities with shipping terms typically specifying F.O.B. shipping point.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <!-- Field: Page; Sequence: 11; Value: 4 --> <!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Performance Obligations</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">A performance obligation is a promise in a contract to transfer a distinct good or service to the customer. A contract&#x2019;s transaction price is allocated to each distinct performance obligation and recognized as revenue when, or as, the performance obligation is satisfied. The Company's contracts <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>contain multiple performance obligations if a promise to transfer the individual goods or services is separately identifiable from other promises in the contracts and, therefore, is considered distinct. For contracts with multiple performance obligations, the Company determines the standalone selling price of each performance obligation and allocates the total transaction price using the relative selling price basis.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The following is a description of the principal goods and services from which the Company generates revenue.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Renewable Product Sales</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Revenues from renewable product sales are recognized as a distinct performance obligation on a gross basis as the Company is acting as a principal in these transactions, with the selling price to the customer recorded net of discounts and allowances. Revenues are recognized at a point in time when control has passed to the customer, which typically is upon the renewable products leaving the Company&#x2019;s facilities with the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> transportation carrier. The Company, on occasion, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>recognize revenue under a bill and hold arrangement, whereby the customer requests and agrees to purchase product but requests delivery at a later date. Under these arrangements, control transfers to the customer when the product is ready for delivery, which occurs when the product is identified separately as belonging to the customer, the product is ready for shipment to the customer in its current form, and the Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> have the ability to direct the product to a different customer. It is at this point that the Company has the right to payment, the customer obtains legal title, and the customer has the significant risks and rewards of ownership. The Company&#x2019;s renewable product sales do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> include rights of return. Returns are accepted only if the product does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> meet product specifications and such nonconformity is communicated to the Company within a set number of days of delivery. The Company offers a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div>-year assurance-type warranty to replace squalane products that do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> meet Company-established criteria as set forth in the Company&#x2019;s trade terms. An estimate of the cost to replace the squalane products sold is made based on a historical rate of experience and recognized as a liability and related expense when the renewable product sale is consummated.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Licenses and Royalties</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Licensing of Intellectual Property: </div>When the Company&#x2019;s intellectual property licenses are determined to be distinct from the other performance obligations identified in the arrangement, revenue is recognized from non-refundable, up-front fees allocated to the license at a point in time when the license is transferred to the licensee and the licensee is able to use and benefit from the license. For intellectual property licenses that are combined with other promises, the Company utilizes judgment to assess the nature of the combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purposes of recognizing revenue from non-refundable, up-front-fees. The Company evaluates the measure of progress each reporting period and, if necessary, adjusts the measure of performance and related revenue recognized.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Royalties from Licensing of Intellectual Property:</div> The Company earns royalties from the licensing of its intellectual property whereby the licensee uses the intellectual property to produce and sell its products to its customers and the Company shares in the profits.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">When the Company&#x2019;s intellectual property license is the only performance obligation, or it is the predominant performance obligation in arrangements with multiple performance obligations, the Company applies the sales-based royalty exception and revenue is estimated and recognized at a point in time when the licensee&#x2019;s product sales occur. Estimates of sales-based royalty revenues are made using the most likely amount method, which is the single amount in a range of possible amounts derived from the licensee&#x2019;s historical sales volumes and sales prices of its products and recent commodity market pricing data and trends.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">When the Company&#x2019;s intellectual property license is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> the predominant performance obligation in arrangements with multiple performance obligations, the royalty represents variable consideration and is allocated to the transaction price of the predominant performance obligation which generally is the supply of renewable products to the Company's customers. Revenue is estimated and recognized at a point in time when the renewable products are delivered to the customer. Estimates of the amount of variable consideration to include in the transaction price are made using the expected value method, which is the sum of probability-weighted amounts in a range of possible amounts determined based on the cost to produce the renewable product plus a reasonable margin for the profit share. The Company only includes an amount of variable consideration in the transaction price to the extent it is probable that a significant reversal in the cumulative revenue recognized will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> occur when the uncertainty associated with the variable consideration is subsequently resolved. Also, the transaction price is reduced for estimates of customer incentive payments payable by the Company for certain customer contracts.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <!-- Field: Page; Sequence: 12; Value: 4 --> <!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Grants and Collaborative Research and Development Services</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Collaborative Research and Development Services:</div> The Company earns revenues from collaboration agreements with customers to perform research and development services to develop new molecules using the Company&#x2019;s technology and to scale production of the molecules for commercialization and use in the collaborator&#x2019;s products. The collaboration agreements generally include providing the Company's collaborators with research and development services and with licenses to the Company&#x2019;s intellectual property to use the technology underlying the development of the molecules and to sell its products that incorporate the technology. The terms of the Company's collaboration agreements typically include <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> or more of the following: advance payments for the research and development services that will be performed, nonrefundable upfront license payments, milestone payments to be received upon the achievement of the milestone events defined in the agreements, and royalty payments upon the commercialization of the molecules in which the Company shares in the customer&#x2019;s profits.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Collaboration agreements are evaluated at inception to determine whether the intellectual property licenses represent distinct performance obligations separate from the research and development services. If the licenses are determined to be distinct, the non-refundable upfront license fee is recognized as revenue at a point in time when the license is transferred to the licensee and the licensee is able to use and benefit from the license while the research and development service fees are recognized over time as the performance obligations are satisfied. The research and development service fees represent variable consideration. Estimates of the amount of variable consideration to include in the transaction price are made using the expected value method, which is the sum of probability-weighted amounts in a range of possible amounts. The Company only includes an amount of variable consideration in the transaction price to the extent it is probable that a significant reversal in the cumulative revenue recognized will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> occur when the uncertainty associated with the variable consideration is subsequently resolved. Revenue is recognized over time using either an input-based measure of labor hours expended or a time-based measure of progress towards the satisfaction of the performance obligations. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Collaboration agreements that include milestone payments are evaluated at inception to determine whether the milestone events are considered probable of achievement and estimates are made of the amount of the milestone payments to include in the transaction price using the most likely amount method which is the single amount in a range of possible amounts. If it is probable that a significant revenue reversal will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> occur, the estimated milestone payment amount is included in the transaction price. Each reporting period, the Company re-evaluates the probability of achievement of the milestone events and any related constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative basis, which would affect collaboration revenues in the period of adjustment. Generally, revenue is recognized using an input-based measure of progress towards the satisfaction of the performance obligations which can be labor hours expended or time-based in proportion to the estimated total project effort or total projected time to complete. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized. Certain performance obligations are associated with milestones agreed between the Company and its customer. Revenue generated from the performance of services in accordance with the milestones in these agreements is recognized upon confirmation from the customer that the milestone has been achieved. In these cases, amounts recognized are constrained to the amount of consideration received upon achievement of the milestone.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The Company generally invoices its collaborators on a monthly or quarterly basis, or upon the completion of the effort or achievement of a milestone, based on the terms of each agreement. Contract liability arises from amounts received in advance of performing the research and development activities and is recognized as revenue in future periods as the performance obligations are satisfied.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Grants:</div> The Company earns revenues from grants with government agencies to, among other things, provide research and development services to develop molecules using the Company&#x2019;s technology, and create research and development tools to improve the timeline and predictability for scaling molecules from proof of concept to market by reducing time and costs. Grants typically consist of research and development milestone payments to be received upon the achievement of the milestone events defined in the agreements.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The milestone payments are evaluated at inception to determine whether the milestone events are considered probable of achievement and estimates are made of the amount of the milestone payments to include in the transaction price using the most likely amount method which is the single amount in a range of possible amounts. If it is probable that a significant revenue reversal will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> occur, the estimated milestone payment amount is included in the transaction price. Each reporting period, the Company re-evaluates the probability of achievement of the milestone events and any related constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative basis, which would affect collaboration revenues in the period of adjustment. Revenue is recognized over time using a time-based measure of progress towards the satisfaction of the performance obligations. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <!-- Field: Page; Sequence: 13; Value: 4 --> <!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">For descriptions of the Company's other significant accounting policies, see the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> Form <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div>-K/A.</div></div></div></div></div></div></div></div></div></div></div> 2000 151000 -380000 7918000 396000 734000 18000 8803000 23920000 38508000 31172000 93600000 P273D P1Y P1Y P1Y <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold; text-align: left">(In thousands)</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">As of March 31, 2019</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 72%; text-align: left">Remaining 2019</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 25%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,920</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2020</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">38,508</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">2021</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,172</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">2022 and thereafter</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 2.5pt">Total from all customers</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">93,600</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="7" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Three Months Ended March 31,</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2019</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 70%; text-align: left">Period-end stock options to purchase common stock</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,427,384</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,365,447</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left"><div style="display: inline; font-size: 10pt">Convertible promissory notes<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(1)</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,699,607</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,347,364</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Period-end common stock warrants</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">26,411,761</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29,759,452</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Period-end restricted stock units</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,493,579</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">706,697</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt">Period-end preferred stock</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,955,732</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,504,212</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt">Total potentially dilutive securities excluded from computation of diluted loss per share</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">52,988,063</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">44,683,172</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; margin-left: 22.5pt; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt; white-space: nowrap">(In thousands)</td> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt; white-space: nowrap">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid; white-space: nowrap">Convertible<br /> Notes</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid; white-space: nowrap">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid; white-space: nowrap">Loans<br /> Payable<br /> and Credit<br /> Facilities</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid; white-space: nowrap">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid; white-space: nowrap">Related<br /> Party<br /> Convertible<br /> Notes</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid; white-space: nowrap">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid; white-space: nowrap">Related<br /> Party Loans<br /> Payable and<br /> Credit<br /> Facilities</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid; white-space: nowrap">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid; white-space: nowrap">Total</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 45%; font-size: 10pt">2019 (remaining nine months)</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 8%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">139,303</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 8%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,689</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 8%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,618</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 8%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,875</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 8%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">176,485</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">2020</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,113</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,500</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,613</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">2021</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">34,776</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28,146</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">62,922</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">2022</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,450</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,450</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">2023</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">399</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">399</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; padding-bottom: 1pt">Thereafter</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,268</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,268</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Total future minimum payments</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">139,303</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">70,695</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,618</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">32,521</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">268,137</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Less: amount representing interest</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(12,303</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(17,883</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(913</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(7,521</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(38,620</div></td> <td style="font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt">Less: future conversion of accrued interest to principal</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(245</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(245</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Present value of minimum debt payments</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">126,755</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">52,812</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,705</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">229,272</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt">Less: current portion of debt principal</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(126,755</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(4,513</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(24,705</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left; border-bottom: Black 1pt solid">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(155,973</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-bottom: 2.5pt">Noncurrent portion of debt principal</td> <td style="font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">48,299</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">73,299</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; margin-left: 22.5pt; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">March 31, 2019</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">December 31, 2018</td> </tr> <tr style="vertical-align: bottom"> <td style="font-weight: bold; text-align: left">(In thousands)</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Principal</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Unamortized Debt (Discount) Premium</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Change in Fair Value</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Net Balance</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Principal</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Unamortized Debt (Discount) Premium</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Change in Fair Value</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Net Balance</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-style: italic; text-align: left">Convertible notes payable</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 28%; text-align: left; padding-left: 10pt">6% convertible notes due 2021</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60,000</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">48</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60,048</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60,000</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,082</div></td> <td style="width: 1%; text-align: left">)</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,918</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-left: 10pt">2015 Rule 144A convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">37,887</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(358</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">37,529</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">37,887</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,413</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">35,474</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-left: 10pt">2014 Rule 144A convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,004</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(289</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,715</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,004</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(867</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,137</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt; padding-left: 10pt">August 2013 financing convertible note</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,863</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(596</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,267</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,415</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(70</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,345</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">126,754</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,243</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">48</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">125,559</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">126,306</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,350</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,082</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">120,874</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-style: italic; text-align: left">Related party convertible notes payable</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-left: 10pt">2014 Rule 144A convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,705</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(346</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,359</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,705</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,038</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,667</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-style: italic; text-align: left">Loans payable and credit facilities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-left: 10pt">GACP secured term loan facility</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">36,000</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,208</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">34,792</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">36,000</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,349</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">34,651</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-left: 10pt">Ginkgo note</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,000</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,832</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,168</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,000</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(4,047</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,953</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt; padding-left: 10pt">Other loans payable</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,813</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,011</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,802</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,910</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,047</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,863</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">52,813</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,051</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">46,762</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">52,910</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,443</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">46,467</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-style: italic; text-align: left">Related party loans payable</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt; padding-left: 10pt">DSM note</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(5,853</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19,147</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,311</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,689</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 2.5pt">Total debt</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">229,272</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(13,493</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">)</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">48</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">215,827</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">228,921</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(17,142</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">)</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,082</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">)</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">209,697</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">Less: current portion</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(153,752</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(147,677</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="padding-bottom: 1pt">Long-term debt, net of current portion</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">62,075</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">62,020</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap">&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="7" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Three Months Ended March 31,</td> </tr> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold"><div style="display: inline; text-decoration: underline;">(In thousands, except shares and per share amounts)</div></td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2019</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> </tr> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-style: italic">Numerator:</td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 70%; text-align: left">Net loss attributable to Amyris, Inc.</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(66,243</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">)</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(92,802</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">Less: losses allocated to participating securities</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,430</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,504</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 2.25pt">Net loss attributable to Amyris, Inc. common stockholders</td> <td style="padding-bottom: 2.25pt">&nbsp;</td> <td style="border-bottom: Black 2.25pt double; text-align: left">$</td> <td style="border-bottom: Black 2.25pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(63,813</div></td> <td style="white-space: nowrap; border-bottom: Black 2.25pt double; text-align: left">)</td> <td style="padding-bottom: 2.25pt">&nbsp;</td> <td style="border-bottom: Black 2.25pt double; text-align: left">$</td> <td style="border-bottom: Black 2.25pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(85,298</div></td> <td style="white-space: nowrap; border-bottom: Black 2.25pt double; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-style: italic">Denominator:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.25pt">Weighted-average shares of common stock outstanding used in computing loss per share of common stock, basic and diluted</td> <td style="padding-bottom: 2.25pt">&nbsp;</td> <td style="border-bottom: Black 2.25pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.25pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">77,512,059</div></td> <td style="white-space: nowrap; border-bottom: Black 2.25pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.25pt">&nbsp;</td> <td style="border-bottom: Black 2.25pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.25pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">51,200,922</div></td> <td style="white-space: nowrap; border-bottom: Black 2.25pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 2.25pt">Loss per share attributable to common stockholders, basic and diluted</td> <td style="padding-bottom: 2.25pt">&nbsp;</td> <td style="border-bottom: Black 2.25pt double; text-align: left">$</td> <td style="border-bottom: Black 2.25pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(0.82</div></td> <td style="white-space: nowrap; border-bottom: Black 2.25pt double; text-align: left">)</td> <td style="padding-bottom: 2.25pt">&nbsp;</td> <td style="border-bottom: Black 2.25pt double; text-align: left">$</td> <td style="border-bottom: Black 2.25pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1.67</div></td> <td style="white-space: nowrap; border-bottom: Black 2.25pt double; text-align: left">)</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="7" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Three Months Ended March 31,</td> </tr> <tr style="vertical-align: bottom"> <td style="font-weight: bold">(In thousands)</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2019</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 70%; text-align: left">Research and development</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">663</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">363</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">Sales, general and administrative</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,789</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">915</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 2.5pt; padding-left: 10pt">Total stock-based compensation expense</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,452</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,278</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; margin-left: 0.25in; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold">(In thousands)</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">March 31, 2019</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">December 31, 2018</td> </tr> <tr style="vertical-align: bottom"> <td style="text-align: center">&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Level&nbsp;1</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Level 2</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Level&nbsp;3</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Total</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Level&nbsp;1</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Level 2</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Level&nbsp;3</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Total</td> </tr> <tr style="vertical-align: bottom"> <td style="font-weight: bold">Liabilities</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; width: 28%">6% Convertible Notes Due 2021</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60,048</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60,048</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,918</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,918</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt; padding-left: 10pt; text-indent: -10pt">Freestanding derivative instruments in connection with the issuance of equity instruments</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,798</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,798</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,796</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,796</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 2.5pt; padding-left: 20pt; text-indent: -10pt">Total liabilities measured and recorded at fair value</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">63,846</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">63,846</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100,714</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100,714</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold; white-space: nowrap"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold; padding-bottom: 1pt; white-space: nowrap">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid; white-space: nowrap">March 31, 2019</td> <td style="font-weight: bold; padding-bottom: 1pt; white-space: nowrap">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid; white-space: nowrap">December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 64%; text-align: left">Raw materials</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,451</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,901</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Work-in-process</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">238</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">539</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt">Finished goods</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,797</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,253</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="padding-bottom: 2.5pt; padding-left: 10pt">Inventories</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,486</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,693</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; margin-left: 49.5pt; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">March 31, 2019</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 64%; text-align: left">Contingent consideration</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,286</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,286</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Deposits</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">145</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,465</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="padding-bottom: 1pt">Other</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,117</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,207</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt; padding-left: 10pt">Other assets</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,548</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,958</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="text-align: center">&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Quantity of Stock Options</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Weighted-<br /> average <br /> Exercise <br /> Price</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Weighted-average<br /> Remaining <br /> Contractual <br /> Life, in Years</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Aggregate<br /> Intrinsic <br /> Value, in Thousands</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 48%">Outstanding - December 31, 2018</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,390,270</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11.55</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8.5</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Granted</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">104,452</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.73</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Exercised</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,612</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3.68</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Forfeited or expired</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(63,726</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">14.27</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Outstanding - March 31, 2019</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,427,384</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11.39</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8.3</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Vested or expected to vest after March 31, 2019</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,874,155</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12.10</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8.3</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Exercisable at March 31, 2019</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">977,466</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">39.20</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.8</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Quantity of Restricted Stock Units</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Weighted-average Grant-date Fair Value</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Weighted-average Remaining Contractual Life, in Years</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 55%">Outstanding - December 31, 2018</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,294,803</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.50</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1.7</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Awarded</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">493,790</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.65</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>RSUs released</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(192,795</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6.55</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>RSUs forfeited</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(102,219</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.61</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Outstanding - March 31, 2019</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,493,579</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.38</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1.5</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Vested or expected to vest after March 31, 2019</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,153,107</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.39</div></td> <td style="text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1.5</div></td> <td style="text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold; border-bottom: Black 1pt solid">Transaction</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Number Outstanding as of December 31, 2018</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Additional Warrants Issued</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Exercises</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Number Outstanding as of March 31, 2019</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 48%">August 2018 warrant exercise agreements</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,097,164</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,097,164</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">May 2017 cash and dilution warrants</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,292,798</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,292,798</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">August 2017 cash and dilution warrants</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,968,116</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,968,116</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>April 2018 warrant exercise agreements</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,616,174</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,616,174</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">July 2015 related party debt exchange</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">663,228</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(471,204</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">192,024</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">February 2016 related party private placement</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">171,429</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">171,429</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>July 2015 private placement</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">81,197</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(8,547</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">72,650</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="padding-bottom: 1pt">Other</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,406</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,406</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">26,891,512</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(479,751</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">)</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">26,411,761</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> 28253000 18100000 3452000 1278000 102219 5.61 493790 4.65 5294803 5493579 5.50 5.38 P1Y255D P1Y182D 192795 6.55 977466 39.20 63726 104452 29000 5390270 5427384 11.55 11.39 4874155 12.10 3.68 14.27 4.73 17.10 P5Y292D P8Y182D P8Y109D P8Y109D 2.87 5.12 4.02 4.76 4.02 4.02 76564829 14656 76564829 14656 77210681 22171 45637433 22171 45850847 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1.</div> Basis of Presentation and Summary of Significant Accounting Policies</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Amyris, Inc. (Amyris or the Company) is a leading industrial biotechnology company that applies its technology platform to engineer, manufacture and sell high performance, natural, sustainably-sourced products into the Health &amp; Wellness, Clean Beauty, and Flavor &amp; Fragrance markets. The Company's proven technology platform enables the Company to rapidly engineer microbes and use them as catalysts to metabolize renewable, plant-sourced sugars into large volume, high-value ingredients. The Company's biotechnology platform and industrial fermentation process replace existing complex and expensive manufacturing processes. The Company has successfully used its technology to develop and produce several distinct molecules at commercial volumes.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The accompanying unaudited condensed consolidated financial statements of Amyris, Inc. should be read in conjunction with the audited consolidated financial statements and notes thereto included in the Company's Annual Report on Form <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div>-K/A for the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> Form <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div>-K/A), from which the condensed consolidated balance sheet as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> is derived. The accompanying condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (U.S. GAAP) for interim financial information and with the instructions to Form <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div>-Q and Article <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div> of Regulation S-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">X.</div> Accordingly, since they are interim statements, the accompanying condensed consolidated financial statements do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> include all of the information and notes required by U.S. GAAP for complete financial statements. The accompanying condensed consolidated financial statements reflect all adjustments, consisting of normal recurring adjustments, that are, in the opinion of management, necessary to a fair statement of the results for the interim periods presented. Interim results are <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> necessarily indicative of results for a full year.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Going Concern</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;">&nbsp;</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The Company has incurred significant operating losses since its inception and expects to continue to incur losses and negative cash flows from operations for at least the next <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12</div> months following the issuance of these condensed consolidated financial statements. As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> the Company had negative working capital of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$199.4</div> million (compared to negative working capital of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$119.5</div> million as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>), and an accumulated deficit of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.6</div> billion.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> the Company's debt (including related party debt), net of debt discount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$13.5</div> million, totaled <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$215.8</div> million, of which <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$153.8</div> million is classified as current. Subsequent to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> the Company entered into arrangements with lenders to extend maturities and convert certain debt obligations into common stock; see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,</div> "Subsequent Events" for more information. The Company's debt service obligations through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2020</div> are <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$179.8</div> million, including <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$23.5</div> million of anticipated cash interest payments. The Company's debt agreements contain various covenants, including certain restrictions on the Company's business that could cause the Company to be at risk of defaults, such as restrictions on additional indebtedness and cross-default clauses. A failure to comply with, or cure non-compliance events or obtain waivers for covenant violations, and other provisions of the Company&#x2019;s debt instruments, including any failure to make a payment when required, would generally result in events of default under such instruments, which could permit acceleration of such indebtedness. If such indebtedness is accelerated, it would generally also constitute an event of default under the Company&#x2019;s other outstanding indebtedness, permitting acceleration of a substantial portion of the Company's outstanding indebtedness.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Cash and cash equivalents of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.2</div> million as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> are <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> sufficient to fund expected future negative cash flows from operations and cash debt service obligations through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2020.</div> These factors raise substantial doubt about the Company&#x2019;s ability to continue as a going concern within <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> year after the date that these condensed consolidated financial statements are issued. The condensed consolidated financial statements do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> include any adjustments that might result from the outcome of this uncertainty. The Company's ability to continue as a going concern will depend, in large part, on its ability to extend existing debt maturities by restructuring a majority of its convertible debt, which is uncertain and outside the control of the Company. Further, the Company's operating plan for the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">twelve</div> months ending <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 31, 2020 </div>contemplates a significant reduction in its net operating cash outflows as compared to the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> resulting from (i) revenue growth from sales of existing and new products with positive gross margins, (ii) significantly increased cash inflows from grants and collaborations, and (iii) reduced production costs as a result of manufacturing and technical developments. If the Company is unable to complete these actions, it expects to be unable to meet its operating cash flow needs and its obligations under its existing debt facilities. This could result in an acceleration of its obligation to repay all amounts outstanding under those facilities, and it <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be required to obtain additional equity or debt financing, which <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> occur timely or on reasonable terms, if at all, and/or liquidate its assets. In such a scenario, the value the Company receives for its assets in liquidation or dissolution could be significantly lower than the value reflected in these condensed consolidated financial statements.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <!-- Field: Page; Sequence: 10; Value: 4 --> <!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 16, 2019, </div>the Company failed to pay an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$63.6</div> million of outstanding principal and accrued interest on the Second Exchange Note when due. The failure resulted in an event of default under the Second Exchange Note and also triggered cross-defaults under other debt instruments of the Company which permitted the holders of such indebtedness to accelerate the amounts owing under such instruments. The Company subsequently received waivers from substantially all holders of such other debt instruments to waive the right to accelerate. As a result, the indebtedness with respect to which the Company has obtained such waivers continues to be classified as long-term on the Company&#x2019;s balance sheet.&nbsp; The indebtedness reflected by the Second Exchange Note continues to be classified as a current liability on the Company&#x2019;s balance sheet. In addition, as a result of the payment default, the conversion price of the Second Exchange Note is subject to adjustment in accordance with the terms of the Second Exchange Note.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> currently have sufficient funds to repay the amounts outstanding under the Second Exchange Note. To date, negotiations with the holder of the Second Exchange Note have <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> been successful, and there can be <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> assurance that a favorable outcome for the Company will be reached. The Company has executed a term sheet with an existing investor for a term loan, the proceeds of which would be used to repay a portion of the Second Exchange Note. However, there can be <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> assurance that the Company will be able to obtain such financing on its expected timeline, or on acceptable terms, if at all. Even if the Company does obtain such financing, it will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> have sufficient funds to repay the Second Exchange Note in full without obtaining additional financing, which the Company is attempting to source. The condensed consolidated financial statements do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> include any adjustments that might result from the outcome of this uncertainty.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Significant Accounting Policies</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,</div> "Basis of Presentation and Summary of Significant Accounting Policies", to the audited consolidated financial statements in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> Form <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div>-K/A includes a discussion of the significant accounting policies and estimates used in the preparation of the Company&#x2019;s consolidated financial statements. There have been <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> material changes to the Company's significant accounting policies and estimates during the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> months ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> except for the Company's adoption of these accounting standards on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2019:</div></div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0">&#x2022; <div style="display: inline; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp; </div>Accounting Standards Codification (ASC) Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">842</div> (ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">842</div>), <div style="display: inline; font-style: italic;">Leases;</div> and</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&#x2022; <div style="display: inline; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp; </div>Accounting Standards Update (ASU) <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,</div><div style="display: inline; font-style: italic;">&nbsp;Earnings Per Share (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">260</div>); Distinguishing Liabilities from Equity (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">480</div>); Derivatives and Hedging (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">815</div>): Accounting for Certain Financial Instruments with Down Round Features</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-weight: bold;">Revenue Recognition</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The Company recognizes revenue from the sale of renewable products, licenses of and royalties from intellectual property, and grants and collaborative research and development services. Revenue is measured based on the consideration specified in a contract with a customer and recognized when, or as, the Company satisfies a performance obligation by transferring control over a product or service to a customer. The Company generally does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> incur costs to obtain new contracts. The costs to fulfill a contract are expensed as incurred.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The Company accounts for a contract when it has approval and commitment to perform from both parties, the rights of the parties are identified, payment terms are established, the contract has commercial substance and collectability of the consideration is probable. Changes to contracts are assessed for whether they represent a modification or should be accounted for as a new contract. The Company considers the following indicators among others when determining whether it is acting as a principal in the transaction and recording revenue on a gross basis: (i) the Company is primarily responsible for fulfilling the promise to provide the specified goods or service, (ii) the Company has inventory risk before the specified good or service has been transferred to a customer or after transfer of control to the customer and (iii) the Company has discretion in establishing the price for the specified good or service. If a transaction does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> meet the Company's indicators of being a principal in the transaction, then the Company is acting as an agent in the transaction and the associated revenues are recognized on a net basis.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The Company&#x2019;s significant contracts and contractual terms with its customers are presented in Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> "Revenue Recognition" in Part II, Item <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8</div> of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> Form <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div>-K/A.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The Company recognizes revenue when control has passed to the customer. The following indicators are evaluated in determining when control has passed to the customer: (i) the Company has a right to payment for the product or service, (ii) the customer has legal title to the product, (iii) the Company has transferred physical possession of the product to the customer, (iv) the customer has the significant risk and rewards of ownership of the product and (v) the customer has accepted the product. The Company&#x2019;s renewable products are delivered to customers from the Company&#x2019;s facilities with shipping terms typically specifying F.O.B. shipping point.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <!-- Field: Page; Sequence: 11; Value: 4 --> <!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Performance Obligations</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">A performance obligation is a promise in a contract to transfer a distinct good or service to the customer. A contract&#x2019;s transaction price is allocated to each distinct performance obligation and recognized as revenue when, or as, the performance obligation is satisfied. The Company's contracts <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>contain multiple performance obligations if a promise to transfer the individual goods or services is separately identifiable from other promises in the contracts and, therefore, is considered distinct. For contracts with multiple performance obligations, the Company determines the standalone selling price of each performance obligation and allocates the total transaction price using the relative selling price basis.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The following is a description of the principal goods and services from which the Company generates revenue.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Renewable Product Sales</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Revenues from renewable product sales are recognized as a distinct performance obligation on a gross basis as the Company is acting as a principal in these transactions, with the selling price to the customer recorded net of discounts and allowances. Revenues are recognized at a point in time when control has passed to the customer, which typically is upon the renewable products leaving the Company&#x2019;s facilities with the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> transportation carrier. The Company, on occasion, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>recognize revenue under a bill and hold arrangement, whereby the customer requests and agrees to purchase product but requests delivery at a later date. Under these arrangements, control transfers to the customer when the product is ready for delivery, which occurs when the product is identified separately as belonging to the customer, the product is ready for shipment to the customer in its current form, and the Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> have the ability to direct the product to a different customer. It is at this point that the Company has the right to payment, the customer obtains legal title, and the customer has the significant risks and rewards of ownership. The Company&#x2019;s renewable product sales do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> include rights of return. Returns are accepted only if the product does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> meet product specifications and such nonconformity is communicated to the Company within a set number of days of delivery. The Company offers a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div>-year assurance-type warranty to replace squalane products that do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> meet Company-established criteria as set forth in the Company&#x2019;s trade terms. An estimate of the cost to replace the squalane products sold is made based on a historical rate of experience and recognized as a liability and related expense when the renewable product sale is consummated.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Licenses and Royalties</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Licensing of Intellectual Property: </div>When the Company&#x2019;s intellectual property licenses are determined to be distinct from the other performance obligations identified in the arrangement, revenue is recognized from non-refundable, up-front fees allocated to the license at a point in time when the license is transferred to the licensee and the licensee is able to use and benefit from the license. For intellectual property licenses that are combined with other promises, the Company utilizes judgment to assess the nature of the combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purposes of recognizing revenue from non-refundable, up-front-fees. The Company evaluates the measure of progress each reporting period and, if necessary, adjusts the measure of performance and related revenue recognized.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Royalties from Licensing of Intellectual Property:</div> The Company earns royalties from the licensing of its intellectual property whereby the licensee uses the intellectual property to produce and sell its products to its customers and the Company shares in the profits.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">When the Company&#x2019;s intellectual property license is the only performance obligation, or it is the predominant performance obligation in arrangements with multiple performance obligations, the Company applies the sales-based royalty exception and revenue is estimated and recognized at a point in time when the licensee&#x2019;s product sales occur. Estimates of sales-based royalty revenues are made using the most likely amount method, which is the single amount in a range of possible amounts derived from the licensee&#x2019;s historical sales volumes and sales prices of its products and recent commodity market pricing data and trends.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">When the Company&#x2019;s intellectual property license is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> the predominant performance obligation in arrangements with multiple performance obligations, the royalty represents variable consideration and is allocated to the transaction price of the predominant performance obligation which generally is the supply of renewable products to the Company's customers. Revenue is estimated and recognized at a point in time when the renewable products are delivered to the customer. Estimates of the amount of variable consideration to include in the transaction price are made using the expected value method, which is the sum of probability-weighted amounts in a range of possible amounts determined based on the cost to produce the renewable product plus a reasonable margin for the profit share. The Company only includes an amount of variable consideration in the transaction price to the extent it is probable that a significant reversal in the cumulative revenue recognized will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> occur when the uncertainty associated with the variable consideration is subsequently resolved. Also, the transaction price is reduced for estimates of customer incentive payments payable by the Company for certain customer contracts.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <!-- Field: Page; Sequence: 12; Value: 4 --> <!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Grants and Collaborative Research and Development Services</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Collaborative Research and Development Services:</div> The Company earns revenues from collaboration agreements with customers to perform research and development services to develop new molecules using the Company&#x2019;s technology and to scale production of the molecules for commercialization and use in the collaborator&#x2019;s products. The collaboration agreements generally include providing the Company's collaborators with research and development services and with licenses to the Company&#x2019;s intellectual property to use the technology underlying the development of the molecules and to sell its products that incorporate the technology. The terms of the Company's collaboration agreements typically include <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> or more of the following: advance payments for the research and development services that will be performed, nonrefundable upfront license payments, milestone payments to be received upon the achievement of the milestone events defined in the agreements, and royalty payments upon the commercialization of the molecules in which the Company shares in the customer&#x2019;s profits.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Collaboration agreements are evaluated at inception to determine whether the intellectual property licenses represent distinct performance obligations separate from the research and development services. If the licenses are determined to be distinct, the non-refundable upfront license fee is recognized as revenue at a point in time when the license is transferred to the licensee and the licensee is able to use and benefit from the license while the research and development service fees are recognized over time as the performance obligations are satisfied. The research and development service fees represent variable consideration. Estimates of the amount of variable consideration to include in the transaction price are made using the expected value method, which is the sum of probability-weighted amounts in a range of possible amounts. The Company only includes an amount of variable consideration in the transaction price to the extent it is probable that a significant reversal in the cumulative revenue recognized will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> occur when the uncertainty associated with the variable consideration is subsequently resolved. Revenue is recognized over time using either an input-based measure of labor hours expended or a time-based measure of progress towards the satisfaction of the performance obligations. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Collaboration agreements that include milestone payments are evaluated at inception to determine whether the milestone events are considered probable of achievement and estimates are made of the amount of the milestone payments to include in the transaction price using the most likely amount method which is the single amount in a range of possible amounts. If it is probable that a significant revenue reversal will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> occur, the estimated milestone payment amount is included in the transaction price. Each reporting period, the Company re-evaluates the probability of achievement of the milestone events and any related constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative basis, which would affect collaboration revenues in the period of adjustment. Generally, revenue is recognized using an input-based measure of progress towards the satisfaction of the performance obligations which can be labor hours expended or time-based in proportion to the estimated total project effort or total projected time to complete. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized. Certain performance obligations are associated with milestones agreed between the Company and its customer. Revenue generated from the performance of services in accordance with the milestones in these agreements is recognized upon confirmation from the customer that the milestone has been achieved. In these cases, amounts recognized are constrained to the amount of consideration received upon achievement of the milestone.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The Company generally invoices its collaborators on a monthly or quarterly basis, or upon the completion of the effort or achievement of a milestone, based on the terms of each agreement. Contract liability arises from amounts received in advance of performing the research and development activities and is recognized as revenue in future periods as the performance obligations are satisfied.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Grants:</div> The Company earns revenues from grants with government agencies to, among other things, provide research and development services to develop molecules using the Company&#x2019;s technology, and create research and development tools to improve the timeline and predictability for scaling molecules from proof of concept to market by reducing time and costs. Grants typically consist of research and development milestone payments to be received upon the achievement of the milestone events defined in the agreements.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The milestone payments are evaluated at inception to determine whether the milestone events are considered probable of achievement and estimates are made of the amount of the milestone payments to include in the transaction price using the most likely amount method which is the single amount in a range of possible amounts. If it is probable that a significant revenue reversal will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> occur, the estimated milestone payment amount is included in the transaction price. Each reporting period, the Company re-evaluates the probability of achievement of the milestone events and any related constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative basis, which would affect collaboration revenues in the period of adjustment. Revenue is recognized over time using a time-based measure of progress towards the satisfaction of the performance obligations. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <!-- Field: Page; Sequence: 13; Value: 4 --> <!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">For descriptions of the Company's other significant accounting policies, see the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> Form <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div>-K/A.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><div style="display: inline; font-weight: bold;">Accounting Standards or Updates Recently Adopted</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">In the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> months ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> the Company adopted these accounting standards or updates:</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Leases</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 2016, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">No.</div>&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">02,</div> <div style="display: inline; font-style: italic;">Leases (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">842</div>).</div> The standard requires the recognition of lease liabilities and right-of-use (ROU) assets on the balance sheet arising from lease transactions at the lease commencement date and the disclosure of key information about leasing arrangements. In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2018, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,</div> <div style="display: inline; font-style: italic;">Leases (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">842</div>) Targeted Improvements</div>, which provides an additional transition method in which the lease standard is applied at the adoption date and recognized as a cumulative-effect adjustment to retained earnings without adjustment to comparative periods (collectively Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">842</div>). The amendment has the same effective date and transition requirements as the lease standard.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The Company adopted this standard on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2019 </div>using the modified retrospective approach and elected the package of practical expedients permitted under transition guidance, which allowed the Company to carry forward its historical assessments of: (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div>) whether contracts are or contain leases, (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div>) lease classification and (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div>) initial direct costs, where applicable. The Company did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> elect the practical expedient allowing the use-of-hindsight which would require the Company to reassess the lease term of its leases based on all facts and circumstances through the effective date and did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> elect the practical expedient pertaining to land easements as this is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> applicable to the Company&#x2019;s current contracts. The Company elected the post-transition practical expedient to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> separate lease components from non-lease components for all leases of manufacturing equipment. The Company also elected a policy of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> recording leases on its condensed consolidated balance sheets when the leases have a term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12</div> months or less and the Company is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> reasonably certain to elect an option to purchase the leased asset.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The adoption of this standard had the effect of increasing assets and liabilities on the condensed consolidated balance sheet by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$25.7</div> million, but did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> have a material impact on the condensed consolidated statements of operations or cash flows.&nbsp; The most significant impact relates to (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div>) the recognition of new ROU assets and lease liabilities on the balance sheet for operating leases; and (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div>) providing significant new disclosures about leasing activities.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">Upon adoption, the Company recognized operating lease liabilities of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$33.6</div> million, based on the present value of the remaining minimum rental payments under current leasing standards for existing operating leases.&nbsp;The Company also recognized ROU assets of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$29.7</div> million, which represents the operating lease liability, adjusted for prepaid expenses and deferred rent. The difference between the operating lease ROU assets and lease liabilities reflects the net of advanced rent payments and deferred rent balances that were derecognized at the time of adoption.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Financial Instruments with "Down Round" Features</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2017, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,</div>&nbsp;<div style="display: inline; font-style: italic;">Earnings Per Share (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">260</div>); Distinguishing Liabilities from Equity (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">480</div>); Derivatives and Hedging (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">815</div>): Accounting for Certain Financial Instruments with Down Round Features</div>. The amendments of this ASU update the classification analysis of certain equity-linked financial instruments, or embedded features, with down round features, as well as clarify existing disclosure requirements for equity-classified instruments. When determining whether certain financial instruments should be classified as liabilities or equity instruments, a down round feature <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> longer precludes equity classification when assessing whether the instrument is indexed to an entity&#x2019;s own stock. The accounting standard update became effective in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> quarter of fiscal year <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> and the Company adopted the standard using a modified retrospective approach. Since the adoption of ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11</div> would have classified the warrants effected as equity at inception, the cumulative-effect adjustment should (i) record the issuance date value of the warrants as if they had been equity classified at the issuance date, (ii) reverse the effects of changes in the fair value of the warrants that had been recorded in the statement of operations of each period, and (iii) eliminate the derivative liabilities from the balance sheet. Upon adoption, the Company (i) recorded an increase of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$32.5</div> million to additional paid-in capital, (ii) recorded a decrease to accumulated deficit of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.5</div> million and (iii) decreased the warrant liability by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$41.0</div> million.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><div style="display: inline; font-weight: bold;">Recent Accounting Standards or Updates <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">Not</div> Yet Effective</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-style: italic;">&nbsp;</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Fair Value Measurement</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2018, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,</div> <div style="display: inline; font-style: italic;">Fair Value Measurement (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">820</div>): Disclosure Framework&#x2014;Changes to the Disclosure Requirements for Fair Value Measurement</div>, which amends ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">820,</div> <div style="display: inline; font-style: italic;">Fair Value Measurement</div>. ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div> modifies the disclosure requirements for fair value measurements by removing, modifying or adding certain disclosures. The accounting standard update will be effective beginning in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> quarter of fiscal <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2020,</div> with removed and modified disclosures to be adopted on a retrospective basis, and new disclosures to be adopted on a prospective basis. The Company is in the initial stages of evaluating the impact of the standard on its condensed consolidated financial statements.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Collaborative Revenue Arrangements</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,</div> <div style="display: inline; font-style: italic;">Clarifying the Interaction between Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">808</div> and Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606</div></div>, that clarifies the interaction between the guidance for certain collaborative arrangements and Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606,</div> the new revenue recognition standard. A collaborative arrangement is a contractual arrangement under which <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> or more parties actively participate in a joint operating activity and are exposed to significant risks and rewards that depend on the activity&#x2019;s commercial success. The ASU provides guidance on how to assess whether certain transactions between collaborative arrangement participants should be accounted for within the revenue recognition standard. The accounting standard update will be effective beginning in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> quarter of fiscal year <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2020</div> retroactively. The Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> believe that the impact of the new standard on its condensed consolidated financial statements will be material.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Credit Losses</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 2016, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,</div> <div style="display: inline; font-style: italic;">Financial Instruments&#x2014;Credit Losses (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">326</div>), Measurement of Credit Losses on Financial Instruments</div>. ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div> requires entities to measure all expected credit losses for most financial assets held at the reporting date based on an expected loss model which includes historical experience, current conditions, and reasonable and supportable forecasts. Entities will now use forward-looking information to better form their credit loss estimates. ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div> also requires enhanced disclosures to help financial statement users better understand significant estimates and judgments used in estimating credit losses, as well as the credit quality and underwriting standards of an entity's portfolio. ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div> will become effective for the Company beginning in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> quarter of fiscal year <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2020.</div> The Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> believe that the impact of the new standard on its condensed consolidated financial statements will be material.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <!-- Field: Page; Sequence: 14; Value: 4 --> <!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"><div style="display: inline; font-weight: bold;">Use of Estimates and Judgements</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates, judgements and assumptions that affect the reported amounts of assets and liabilities, disclosures of contingent assets and liabilities at the date of the condensed consolidated financial statements, and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates, and such differences <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be material to the condensed consolidated financial statements.</div></div> 6732369 2832440 2043781 913529 323382 1243781 13529 191672 30489 3612 3612 7004 92000 92000 -9000 -9000 -66000 -66000 13000 13000 81000 81000 -238137000 -217756000 -237200000 -216819000 8000 1346996000 -43343000 -1521417000 937000 5000000 8000 1383363000 -42379000 -1579129000 937000 5000000 5000 1114546000 -42156000 -1290420000 937000 -217088000 5000000 5000 1116859000 -42293000 -1384025000 937000 -308517000 5000000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6.</div> Stockholders' Deficit</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 7pt 0pt 0; text-align: justify; text-indent: 22.5pt; color: #231F20"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Warrants</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In connection with various debt and equity transactions (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> "Debt" and Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,</div> &#x201c;Stockholders&#x2019; Deficit&#x201d; in Part II, Item <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8</div> of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> Form <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div>-K/A), the Company has issued warrants exercisable for shares of common stock. The following table summarizes warrant activity for the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> months ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019:</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold; border-bottom: Black 1pt solid">Transaction</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Number Outstanding as of December 31, 2018</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Additional Warrants Issued</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Exercises</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Number Outstanding as of March 31, 2019</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 48%">August 2018 warrant exercise agreements</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,097,164</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,097,164</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">May 2017 cash and dilution warrants</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,292,798</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,292,798</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">August 2017 cash and dilution warrants</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,968,116</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,968,116</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>April 2018 warrant exercise agreements</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,616,174</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,616,174</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">July 2015 related party debt exchange</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">663,228</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(471,204</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">192,024</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">February 2016 related party private placement</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">171,429</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">171,429</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>July 2015 private placement</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">81,197</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(8,547</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">72,650</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="padding-bottom: 1pt">Other</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,406</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,406</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">26,891,512</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(479,751</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">)</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">26,411,761</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <!-- Field: Page; Sequence: 20; Value: 4 --> <!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">For the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> months ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">479,751</div> shares of common stock were issued under certain anti-dilution warrants with an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.01</div> and resulted in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> proceeds to the Company. The shares were exercised through net share settlement, resulting in the issuance of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">450,568</div> shares.</div></div> 93000 93000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12.</div> Subsequent Events</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;">Cannabinoid Agreement</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2, 2019, </div>the Company consummated an agreement entered into <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 18, 2019 </div>related to a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$300</div> million research, collaboration and license agreement (the Cannabinoid Agreement) with LAVVAN, Inc., a newly formed investment-backed company (Lavvan), for the development, manufacture and commercialization of cannabinoids, subject to certain closing conditions noted below. Under the agreement, the Company would perform research and development activities and Lavvan would be responsible for the commercialization of the cannabinoids developed under the agreement. The Cannabinoid Agreement is being principally funded on a milestone basis, with the Company also entitled to receive certain supplementary research and development funding from Lavvan. The Company could receive aggregate funding of up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$300</div> million over the term of the Cannabinoid Agreement if all of the milestones are achieved. Additionally, the agreement provides for profit share to the Company on Lavvan's gross profit margin once products are commercialized; these payments will be due for the next <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">20</div> years. The consummation of the transactions contemplated by the Cannabinoid Agreement is subject to certain conditions, including obtaining certain <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">third</div> party consents and releases and the repayment or refinancing of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes and the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,</div> &#x201c;Debt&#x201d;). On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2, 2019, </div>the parties consummated the transactions contemplated by the Cannabinoid Agreement, including the formation of a special purpose entity to hold certain intellectual property created during the collaboration (the Cannabinoid Collaboration IP), the licensing of certain Company intellectual property to Lavvan, the licensing of the Cannabinoid Collaboration IP to the Company and Lavvan, and the granting by the Company to Lavvan of a lien on the Company background intellectual property being licensed to Lavvan under the Cannabinoid Agreement, which lien would be subordinated to the lien on such intellectual property under the GACP Term Loan Facility (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,</div> &#x201c;Debt&#x201d;).</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;">LSA Amendments, Assignment and Waivers</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 4, 2019, </div>the Company and GACP amended the LSA (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,</div> &#x201c;Debt&#x201d;) to (i) effective <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018, </div>eliminate the conditions giving rise to the early maturity date, so that loans under the GACP Term Loan Facilities would have a maturity date of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 1, 2021, (</div>ii) remove certain Company intellectual property related to the Cannabinoid Agreement from the lien granted by the Company to GACP under the LSA, (iii) eliminate the Company&#x2019;s ability to obtain the Incremental GACP Term Loan Facility, (iv) eliminate the Company&#x2019;s reinvestment rights with respect to mandatory prepayments upon asset sales, (v) restrict the Company&#x2019;s ability to pay interest and principal on other indebtedness without the consent of GACP, and (vi) provide that the Company must have at all times at least <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$15</div> million of unrestricted, unencumbered cash subject to a control agreement in favor of GACP.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 4, 2019, </div>the Company and GACP entered into a waiver agreement, pursuant to which GACP agreed to waive breaches of certain covenants under the LSA occurring prior to, as of and after <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018 </div>through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 8, 2019, </div>including covenants related to quarterly minimum revenues, minimum liquidity amounts and a minimum asset coverage ratio. In connection with such waiver, the Company agreed to pay GACP fees of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.8</div> million.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 15, 2019, </div>the Company, GACP and Foris Ventures, LLC (Foris, an entity affiliated with director John Doerr of Kleiner Perkins Caufield &amp; Byers, a current stockholder, and an owner of greater than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">five</div> percent of the Company&#x2019;s outstanding common stock) entered into a Loan Purchase Agreement, pursuant to which Foris agreed to purchase and assume from GACP, and GACP agreed to sell and assign to Foris, the outstanding loans under the LSA and all documents and assets related thereto. In connection with such purchase and assignment, the Company agreed to repay Foris <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.5</div> million of the purchase price paid by Foris to GACP (the Company LPA Obligation). The closing of the loan purchase and assignment occurred on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 16, 2019.</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 14, 2019, </div>the Company and Foris entered into an Amendment <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">No.</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5</div> and Waiver to the LSA (the LSA Amendment and Waiver), pursuant to which (i) the maturity date of the loans under the LSA was extended from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 1, 2021 </div>to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 1, 2022, (</div>ii) the interest rate for the loans under the LSA was modified from the sum of (A) the greater of (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">x</div>) the prime rate as reported in the Wall Street Journal or (y)&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.75%</div> plus (B)&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9%</div> to the greater of (A) <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12%</div> or (B) the rate of interest payable with respect to any indebtedness of the Company, (iii) the amortization of the loans under the LSA was delayed until <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 16, 2019, (</div>iv) certain accrued and future interest and agency fee payments under the LSA were delayed until <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 16, 2019, (</div>v) certain covenants under the LSA, including related definitions, were amended to provide the Company with greater operational and financial flexibility, including, without limitation, to permit the incurrence of the indebtedness under the Naxyris Loan Facility (as described below) and the granting of liens with respect thereto, subject to the terms of an intercreditor agreement between Foris and Naxyris S.A. (Naxyris) governing the respective rights of the parties with respect to, among other things, the assets securing the Naxyris Loan Agreement and the LSA (the Intercreditor Agreement), (vi) certain outstanding unsecured promissory notes issued by the Company to Foris on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 8, 2019, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 11, 2019, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 10, 2019 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 26, 2019 (</div>as described below under &#x201c;Foris Credit Agreements&#x201d;), in an aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$32.5</div> million, as well as the Company LPA Obligation, were added to the loans under the LSA, made subject to the LSA and secured by the security interest in the collateral granted to Foris under the LSA, and such promissory notes and contractual obligation were canceled in connection therewith, and (vii) Foris agreed to waive certain existing defaults under the LSA. After giving effect to the LSA Amendment and Waiver, there is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$71.0</div> million aggregate principal amount of loans outstanding under the LSA, subject to quarterly covenants including minimum revenues, minimum liquidity amounts and a minimum asset coverage ratio. In connection with the entry into the LSA Amendment and Waiver, on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 14, 2019 </div>the Company issued to Foris a warrant to purchase up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,438,829</div> shares of Common Stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.87</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance. Pursuant to the terms of the warrant, Foris <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> exercise the Foris Warrant to the extent that, after giving effect to such exercise, Foris, together with its affiliates, would beneficially own in excess of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19.99%</div> of the number of shares of common stock outstanding after giving effect to such exercise, unless the Company has obtained stockholder approval to exceed such limit in accordance with Nasdaq&nbsp;rules and regulations, which the Company intends to seek at its <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> annual meeting of stockholders.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</div> <!-- Field: Page; Sequence: 26; Value: 4 --> <!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;">Foris Credit Agreements</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 8, 2019, </div>the Company and Foris entered into a credit agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.0</div> million (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Credit Agreement), which the Company borrowed in full on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 8, 2019 </div>and issued to Foris a promissory note in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.0</div> million (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Note). The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Note has a maturity date of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 14, 2019. </div>In connection with the entry into the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Credit Agreement and the issuance of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Note, which has <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> stated interest rate, the Company agreed to pay Foris a fee of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.0</div> million, payable on or prior to the maturity date of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Note (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Note Fee); provided, that the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Note Fee will be reduced to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.5</div> million if the Company repays the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Note in full by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 15, 2019. </div>The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Note is subordinated in right of payment to the Tranche II Note held by Wolverine (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,</div> &#x201c;Debt&#x201d; and above in this Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,</div> &#x201c;Subsequent Events&#x201d;).</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 11, 2019, </div>the Company and Foris entered into a credit agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.5</div> million, which the Company borrowed in full on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 11, 2019 </div>and issued to Foris a promissory note in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.5</div> million (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June </div>Foris Note). The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June </div>Foris Note (i) accrues interest at a rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12.5%</div> per annum from and including <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 11, 2019, </div>which interest is payable on the maturity date or the earlier repayment or other satisfaction of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June </div>Foris Note, and (ii) matures on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 28, 2019; </div>provided, that if the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Cash Warrant held by DSM and the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Cash Warrant (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,</div> &#x201c;Stockholders&#x2019; Deficit&#x201d;) are exercised,&nbsp;then the maturity date of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June </div>Foris Note will be the business day immediately following such exercise.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 10, 2019, </div>the Company and Foris entered into a credit agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$16.0</div> million (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July </div>Foris Credit Agreement), of which the Company borrowed <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.0</div> million on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 10, 2019 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.0</div> million on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 26, 2019 </div>and issued to Foris promissory notes, each in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.0</div> million, on such dates (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July </div>Foris Notes). The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July </div>Foris Notes (i) accrue interest at a rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12.5%</div> per annum from and including the respective date of issuance, which interest is payable on the maturity date or the earlier repayment or other satisfaction of the applicable <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July </div>Foris Note, and (ii) mature on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2019. </div>In connection with the entry into the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July </div>Foris Credit Agreement, the Company and Foris amended the warrant issued to Foris on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 17, 2018 (</div>see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,</div> &#x201c;Stockholders&#x2019; Deficit&#x201d;) to reduce the exercise price of such warrant from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$7.52</div> per share to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.87</div> per share.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>at its option repay the amounts outstanding under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Note (including the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Note Fee), the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June </div>Foris Note and the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July </div>Foris Notes before their respective maturity dates, in whole or in part, at a price equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100%</div> of the amount being repaid plus, in the case of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June </div>Foris Note and the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July </div>Foris Notes, accrued and unpaid interest on such amount to the date of repayment.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 14, 2019, </div>the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Note, the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June </div>Foris Note and the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July </div>Foris Notes were added to the loans under the LSA, made subject to the LSA and secured by the security interest in the collateral granted to Foris under the LSA, and such notes were canceled in connection therewith. See above under &#x201c;LSA Amendments, Assignment and Waivers&#x201d; for additional information.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 28, 2019, </div>the Company and Foris entered into a credit agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$19.0</div> million (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August </div>Foris Credit Agreement), which the Company borrowed in full on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 28, 2019 </div>and issued to Foris a promissory note in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$19.0</div> million (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August </div>Foris Note). The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August </div>Foris Note (i) accrues interest at a rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12%</div> per annum from and including <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 28, 2019, </div>which interest is payable quarterly in arrears on each <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 31, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 30, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 30 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, </div>beginning <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2019, </div>and (ii) matures on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2023. </div>The Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>at its option repay the amounts outstanding under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August </div>Foris Note before the maturity date, in whole or in part, at a price equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100%</div> of the amount being repaid plus accrued and unpaid interest on such amount to the date of repayment. Also, on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 28, 2019 </div>in connection with the entry into the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August </div>Foris Credit Agreement, the Company and Foris amended the warrant issued to Foris on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 26, 2019 </div>to reduce the exercise price of such warrant from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.12</div> per share to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.90</div> per share, and amended the warrant issued to Foris on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 14, 2019 </div>to reduce the exercise price of such warrant from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.56</div> per share to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.90</div> per share. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,</div> &#x201c;Stockholders&#x2019; Deficit&#x201d; for information on the original warrants.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</div> <!-- Field: Page; Sequence: 27; Value: 4 --> <!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">In connection with the entry into the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August </div>Foris Credit Agreement, on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 14, 2019 </div>the Company issued to Foris a warrant to purchase up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,871,795</div> shares of Common Stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.90</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance in a private placement pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div>) of the Securities Act of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1933,</div> as amended (the Securities Act), and Regulation D promulgated under the Securities Act. The exercise price of the warrant is subject to standard adjustments but does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> contain any anti-dilution protection, and the warrants only permit &#x201c;cashless&#x201d; or &#x201c;net&#x201d; exercise after the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">six</div>-month anniversary of issuance of the applicable warrant, and only to the extent that there is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, Foris <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> exercise the warrant to the extent that, after giving effect to such exercise, Foris, together with its affiliates, would beneficially own in excess of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19.99%</div> of the number of shares of common stock outstanding after giving effect to such exercise, unless the Company has obtained stockholder approval to exceed such limit in accordance with Nasdaq&nbsp;rules and regulations, which the Company intends to seek at its <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> annual meeting of stockholders.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;">Private Placements</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> the Company sold and issued to Foris <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,732,369</div> shares of common stock at a price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.87</div> per share, as well as a warrant to purchase up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,424,804</div> shares of common stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.87</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance, in a private placement pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div>) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$20.0</div> million (the Foris Investment).</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 26, 2019, </div>the Company sold and issued (i) <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,832,440</div> shares of common stock at a price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.12</div> per share, as well as a warrant to purchase up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,983,230</div> shares of common stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.12</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance, to Foris and (ii) an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,043,781</div> shares of common stock at a price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.02</div> per share, as well as warrants to purchase up to an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,635,025</div> shares of common stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.02</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance, to certain other non-affiliated investors, in each case in private placements pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div>) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$23.2</div> million. On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 28, 2019, </div>in connection with the entry into the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August </div>Foris Credit Agreement (as described above under "Foris Credit Agreements"), the Company and Foris amended the warrant issued to Foris on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 26, 2019 </div>to reduce the exercise price of such warrant from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.12</div> per share to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.90</div> per share.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 29, 2019, </div>the Company sold and issued (i) <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">913,529</div> shares of common stock at a price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.76</div> per share, as well as a warrant to purchase up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,212,787</div> shares of common stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.76</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance, to Vivo and (ii) an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">323,382</div> shares of common stock at a price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.02</div> per share, as well as warrants to purchase up to an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">258,704</div> shares of common stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.02</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance, to certain other non-affiliated investors, in each case in private placements pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div>) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.8</div> million.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 3, 2019, </div>the Company sold and issued <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,243,781</div> shares of common stock at a price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.02</div> per share, as well as a warrant to purchase up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">995,024</div> shares of common stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.02</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance, to a non-affiliated investor in a private placement pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div>) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5</div> million.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The exercise price of the warrants issued in the foregoing private placements is subject to standard adjustments but does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> contain any anti-dilution protection, and the warrants only permit &#x201c;cashless&#x201d; or &#x201c;net&#x201d; exercise after the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">six</div>-month anniversary of issuance of the applicable warrant, and only to the extent that there is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, in connection with the foregoing private placements, the Company agreed <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> to effect any exercise or conversion of any Company security, and the investors agreed <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> to exercise or convert any portion of any Company security, to the extent that after giving effect to such exercise or conversion, the applicable investor, together with its affiliates, would beneficially own in excess of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19.99%</div> of the number of shares of common stock outstanding immediately after giving effect to such exercise or conversion, and the warrant contained a similar limitation.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <!-- Field: Page; Sequence: 28; Value: 4 --> <!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;">DSM Agreements</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 16, 2019, </div>the Company assigned to DSM, and DSM assumed, all of the Company&#x2019;s rights and obligations under the Value Sharing Agreement (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,</div> &#x201c;Revenue Recognition&#x201d;), for aggregate consideration to the Company of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$57.0</div> million, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$29.1</div> million of which was paid to the Company in cash, with the remaining <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$27.9</div> million being used to pay certain existing obligations of the Company to DSM. The Company used a majority of the cash proceeds to repay a portion of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,</div> &#x201c;Debt&#x201d;).</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In addition, on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 16, 2019 </div>the Company and DSM entered into amendments to the Supply Agreement and the Performance Agreement (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,</div> &#x201c;Revenue Recognition&#x201d;), as well as the Quota Purchase Agreement relating to the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2017 </div>sale of Amyris Brasil to DSM (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,</div> &#x201c;Divestiture&#x201d; in Part II, Item <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8</div> of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> Form <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div>-K/A), pursuant to which (i) DSM agreed to reduce certain manufacturing costs and fees paid by the Company related to the production of farnesene under the Supply Agreement through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021,</div> as well as remove the priority of certain customers over the Company with respect to production capacity at the Brotas, Brazil facility, (ii) the Company agreed to provide DSM rights to conduct certain process and downstream recovery improvements under the Performance Agreement at facilities other than the Brotas, Brazil facility in exchange for DSM providing the Company with a license to such improvements and (iii) the Company released DSM from its obligation to provide manufacturing and support services under the Quota Purchase Agreement in connection with the Company&#x2019;s planned new manufacturing facility, which is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> longer planned to be located at the Brotas, Brazil location.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 17, 2019, </div>the Company and DSM entered into a credit agreement (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x201c;2019</div> DSM Credit Agreement&#x201d;) to make available to the Company a secured credit facility in an aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.0</div> million, to be issued in separate installments of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.0</div> million, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.0</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.0</div> million, respectively, with each installment being subject to certain closing conditions, including the payment of certain existing obligations of the Company to DSM. On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 17, 2019, </div>the Company borrowed the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> installment of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.0</div> million under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> DSM Credit Agreement, all of which proceeds were used to pay certain existing obligations of the Company to DSM, and issued to DSM a promissory note in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.0</div> million. On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 19, 2019, </div>the Company borrowed the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">second</div> installment of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.0</div> million under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> DSM Credit Agreement, all of which proceeds were used to pay certain existing obligations of the Company to DSM, and issued to DSM a promissory note in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.0</div> million. On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 23, 2019, </div>the Company borrowed the final installment of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.0</div> million under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> DSM Credit Agreement, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.5</div> million of which proceeds were used to pay certain existing obligations of the Company to DSM, and issued to DSM a promissory note in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.0</div> million. The promissory notes issued under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> DSM Credit Agreement (i) mature on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 7, 2022, (</div>ii) accrue interest at a rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12.5%</div> per annum from and including the applicable date of issuance, which interest is payable quarterly in arrears on each <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 1, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 1 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 1, </div>beginning <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2020, </div>and (iii) are secured by a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div>-priority lien on certain Company intellectual property licensed to DSM. The Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>at its option repay the amounts outstanding under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> DSM Credit Agreement before the maturity date, in whole or in part, at a price equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100%</div> of the amount being repaid plus accrued and unpaid interest on such amount to the date of repayment. In addition, the Company is required to repay the amounts outstanding under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> DSM Credit Agreement (i) in an amount equal to the gross cash proceeds, if any, received by the Company upon the exercise by DSM of any of the common stock purchase warrants issued by the Company to DSM on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 11, 2017 </div>or <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 7, 2017 (</div>see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,</div> &#x201c;Stockholders&#x2019; Deficit&#x201d;) and (ii) in full upon the request of DSM at any time following the receipt by the Company of at least <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$50.0</div> million of gross cash proceeds from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> or more sales of equity securities of the Company on or prior to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 30, 2020.</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;">Raizen Joint Venture Agreement</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 10, 2019, </div>the Company and Raizen Energia S.A. (Raizen) entered into a joint venture agreement relating to the formation and operation of a joint venture relating to the production, sale and commercialization of alternative sweetener products. In connection with the formation of the joint venture, among other things, (i) the joint venture will construct a manufacturing facility on land owned by Raizen and leased to the joint venture (the Sweetener Plant), (ii) the Company will grant to the joint venture an exclusive, royalty-free, worldwide, license to certain technology owned by the Company relevant to the joint venture&#x2019;s business, and (iii) the Company and Raizen will enter into a shareholders agreement setting forth the rights and obligations of the parties with respect to, and the management of, the joint venture. The formation of the joint venture is subject to certain conditions, including certain regulatory approvals and the achievement of certain technological and economic milestones relating to the Company&#x2019;s existing production of its alternative sweetener product. If such conditions are <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> satisfied by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2019, </div>the joint venture will automatically terminate. In addition, notwithstanding the satisfaction of the closing conditions, Raizen <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>elect <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> to consummate the formation and operation of the joint venture, in which event, the Company will retain the right to construct and operate the Sweetener Plant.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Upon the closing of the joint venture, each party will make an initial capital contribution to the joint venture of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,500,000</div> Brazilian Real (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">R$2,500,000</div>) and the joint venture will be owned <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50%</div> by the Company and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50%</div> by Raizen. Within <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60</div> days of the formation, the parties will make an aggregate cash contribution to the joint venture of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">U.S.$9,000,000</div> to purchase certain fixed assets currently owned by the Company and located at the site of the Company&#x2019;s former joint venture with Sao Martinho S.A. in Pradopolis, Brazil for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">U.S.$3,000,000.</div> In addition, within <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">six</div> months of the formation, the Company will contribute to the joint venture its existing supply agreements related to its alternative sweetener product, subject to certain exceptions, in exchange for shares of dividend-bearing preferred stock in the joint venture, which will be entitled, for a period of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div> years commencing from the initial date of operation of the Sweetener Plant, to certain priority fixed cumulative dividends including, in the event that certain technological and economic milestones are met in any fiscal quarter, a percentage of the operating cash flow of the joint venture in such quarter.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <!-- Field: Page; Sequence: 29; Value: 4 --> <!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">After the formation of the joint venture, the parties will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> conduct activities similar or identical to the joint venture. In the event that certain technological and economic milestones are <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> met in any fiscal year beginning with the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">third</div> fiscal year after formation of the joint venture and ending with the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">seventh</div> fiscal year after formation of the joint venture, Raizen shall have the right to sell all of its shares in the joint venture to the Company at a price per share equal to the higher of the book value and the amount of Raizen&#x2019;s investments in the joint venture, as adjusted for Raizen&#x2019;s cost of capital.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes Exchanges</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 16, 2019, </div>the Company repaid in cash the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$37.9</div> million outstanding balance under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 10, 2019, </div>the Company exchanged <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$13.5</div> million aggregate principal amount of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,</div> &#x201c;Debt&#x201d;) held by certain non-affiliated investors, including accrued and unpaid interest thereon up to, but excluding, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 15, 2019, </div>for an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,479,008</div> shares of common stock and warrants to purchase an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,391,603</div> shares of common stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.02</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance, in a private exchange pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9</div>) of the Securities Act.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 14, 2019, </div>the Company exchanged <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.0</div> million aggregate principal amount of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes held by Foris, including accrued and unpaid interest thereon up to, but excluding, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 15, 2019, </div>for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,122,460</div> shares of common stock and a warrant to purchase up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">352,638</div> shares of common stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.56</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance, in a private exchange pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9</div>) of the Securities Act. On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 28, 2019, </div>in connection with the entry into the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August </div>Foris Credit Agreement (as described above under "Foris Credit Agreements"), the Company and Foris amended the warrant issued to Foris on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 14, 2019 </div>to reduce the exercise price of such warrant from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.56</div> per share to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.90</div> per share.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 15, 2019, </div>the Company exchanged <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$10.0</div> million aggregate principal amount of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes held by Maxwell (Mauritius) Pte Ltd for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,500,000</div> shares of common stock in a private exchange pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9</div>) of the Securities Act.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 15, 2019, </div>the Company exchanged <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$9.7</div> million aggregate principal amount of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes held by Total for a new senior convertible note with an equal principal amount and with substantially identical terms, except that the new note had a maturity date of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 14, 2019, </div>in a private exchange pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9</div>) of the Securities Act. Effective <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 14, 2019, </div>the Company and Total agreed to extend the maturity date of the new note from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 14, 2019 </div>to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 18, 2019. </div>Effective <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 18, 2019, </div>the Company and Total agreed to (i) further extend the maturity date of the new note from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 18, 2019 </div>to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 28, 2019 </div>and (ii) increase the interest rate on the new note to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10.50%</div> per annum, beginning <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 18, 2019.</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The exercise price of the warrants issued in the foregoing exchanges is subject to standard adjustments but does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> contain any anti-dilution protection, and the warrants only permit &#x201c;cashless&#x201d; or &#x201c;net&#x201d; exercise after the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">six</div>-month anniversary of the exercisability of the applicable warrant, and only to the extent that there is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, (i) the exercisability of the warrant issued to Foris is subject to stockholder approval in accordance with Nasdaq&nbsp;rules and regulations, which the Company intends to seek at its <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> annual meeting of stockholders, and (ii) each warrant provides that the Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> effect any exercise of such warrant to the extent that, after giving effect to such exercise, the applicable holder, together with its affiliates, would beneficially own in excess of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.99%</div> of the number of shares of common stock outstanding after giving effect to such exercise.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> Exchanges</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 15, 2019 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 24, 2019, </div>the Company exchanged <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$53.3</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.7</div> million principal amount, respectively, of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,</div> &#x201c;Debt&#x201d;), including accrued and unpaid interest thereon, representing all then-outstanding <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021,</div> for new senior convertible notes with an equal principal amount and warrants to purchase up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,000,000</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">181,818</div> shares of common stock, respectively, at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.12</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance, in private exchanges pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9</div>) of the Securities Act. The new notes have substantially identical terms as the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> being exchanged, except that (i) the holders agreed to waive, until <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 22, 2019, </div>certain covenants relating to the effectiveness of the registration statement covering the shares of common stock issuable upon conversion of, or otherwise pursuant to, the new notes and the filing by the Company of reports with the SEC and (ii) during the period from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 22, 2019 </div>to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 29, 2019, </div>inclusive, the holders have the right to require the Company to redeem the new notes, in whole or in part, at a price equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">125%</div> of the principal amount being redeemed. The exercise price of the warrants is subject to standard adjustments but does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> contain any anti-dilution protection, and the warrants only permit &#x201c;cashless&#x201d; or &#x201c;net&#x201d; exercise after the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">six</div>-month anniversary of issuance, and only to the extent that there is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, the holders <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> exercise the warrants, and the Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> affect any exercise of the warrants, to the extent that, after giving effect to such exercise, the applicable holder, together with its affiliates, would beneficially own in excess of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.99%</div> of the number of shares of common stock outstanding after giving effect to such exercise.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <!-- Field: Page; Sequence: 30; Value: 4 --> <!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 23pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 24, 2019, </div>Company further exchanged <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$53.3</div> million principal amount of the previously-exchanged <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Senior Notes due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> as well as the warrant to purchase up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,000,000</div> shares of common stock issued on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 15, 2019, </div>for a new senior convertible note with a principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$68.3</div> million (the Second Exchange Note) and a new warrant to purchase up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,000,000</div> shares of common stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.87</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 15, 2019 (</div>the Second Exchange Warrant) in a private exchange pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9</div>) of the Securities Act. The Second Exchange Note and Second Exchange Warrant have substantially similar terms as the note and warrant, respectively, issued on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 15, 2019, </div>except that (i) the principal amount of the Second Exchange Note would be <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$68.3</div> million, reflecting accrued and unpaid interest and late charges under the exchanged note and a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25%</div> premium accruing as a result of the Company&#x2019;s failure to make an installment payment on the exchanged note due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 1, 2019 </div>in the amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.4</div> million, provided that upon an event of default under the Second Exchange Note, the Company would <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> be required to redeem the Second Exchange Note in cash at a price greater than&nbsp;the intrinsic value of the shares of common stock underlying the Second Exchange Note, (ii) the Second Exchange Note bears interest at a rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18%</div> per annum, (iii) the holder agreed to extend its waiver of certain covenant breaches relating to the failure by the Company to timely file periodic reports with the SEC from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 22, 2019 </div>to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 16, 2019, (</div>iv) the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> installment date under the Second Exchange Note will occur on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 1, 2019, (</div>v) the Company is required to (A) make principal payments on the Second Exchange Note in the amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.2</div> million on each of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2, 2019 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 22, 2019, </div>and (B) pay all remaining amounts then outstanding under the Second Exchange Note on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 16, 2019, </div>and if the Company fails to make any such payment on the applicable payment date, the conversion price of the Second Exchange Note will be reset to the volume-weighted average price of the common stock on the trading day immediately following the Company&#x2019;s filing of a Current Report on Form <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8</div>-K with respect to its failure to make the payment due on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 16, 2019, </div>if such volume-weighted average price is lower than the conversion price of the Second Exchange Note then in effect, subject to a price floor and (vi) the Second Exchange Warrant has an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.87</div> per share.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 23pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 23pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 26, 2019, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> of the holders of the senior convertibles notes issued in exchange for the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021,</div> holding a senior convertible note in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.7</div> million issued on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 24, 2019, </div>exercised its right to require the Company to redeem such note in whole at a price equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">125%</div> of the principal amount being redeemed, plus accrued and unpaid interest on such note to the date of repayment. Redemption of such note was initially due on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 30, 2019 </div>and subsequently extended to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 30, 2019. </div>The Company redeemed such note in full on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 30, 2019.</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 22.5pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 16, 2019, </div>the Company failed to pay an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$63.6</div> million of outstanding principal and accrued interest on the Second Exchange Note when due. The failure resulted in an event of default under the Second Exchange Note and also triggered cross-defaults under other debt instruments of the Company which permitted the holders of such indebtedness to accelerate the amounts owing under such instruments. The Company subsequently received waivers from substantially all holders of such other debt instruments to waive the right to accelerate. As a result, the indebtedness with respect to which the Company has obtained such waivers continues to be classified as long-term on the Company&#x2019;s balance sheet.&nbsp; The indebtedness reflected by the Second Exchange Note continues to be classified as a current liability on the Company&#x2019;s balance sheet. In addition, as a result of the payment default, the conversion price of the Second Exchange Note is subject to adjustment in accordance with the terms of the Second Exchange Note.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> currently have sufficient funds to repay the amounts outstanding under the Second Exchange Note. To date, negotiations with the holder of the Second Exchange Note have <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> been successful, and there can be <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> assurance that a favorable outcome for the Company will be reached. The Company has executed a term sheet with an existing investor for a term loan, the proceeds of which would be used to repay a portion of the Second Exchange Note. However, there can be <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> assurance that the Company will be able to obtain such financing on its expected timeline, or on acceptable terms, if at all. Even if the Company does obtain such financing, it will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> have sufficient funds to repay the Second Exchange Note in full without obtaining additional financing, which the Company is attempting to source. The condensed consolidated financial statements do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> include any adjustments that might result from the outcome of this uncertainty.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</div> <!-- Field: Page; Sequence: 31; Value: 4 --> <!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22pt"><div style="display: inline; font-style: italic;">Exchange of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2013 </div>Financing Convertible Note</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22pt"><div style="display: inline; font-style: italic;">&nbsp;</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 8, 2019, </div>the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2013 </div>Financing Convertible Note held by Wolverine (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,</div> &#x201c;Debt&#x201d;) was exchanged for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,767,632</div> shares of common stock and a warrant to purchase <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,080,000</div> shares of common stock in a private exchange pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9</div>) of the Securities Act. The exercise price of the warrant is subject to standard adjustments but does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> contain any anti-dilution protection, and the warrant only permits &#x201c;cashless&#x201d; or &#x201c;net&#x201d; exercise after the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">six</div>-month anniversary of issuance, and only to the extent that there is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> an effective registration statement covering the resale of the shares of common stock underlying the warrant. In addition, Wolverine <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> exercise the warrant to the extent that, after giving effect to such exercise, Wolverine, together with its affiliates, would beneficially own in excess of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.99%</div> of the number of shares of common stock outstanding after giving effect to such exercise.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"><div style="display: inline; font-style: italic;">&nbsp;</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"><div style="display: inline; font-style: italic;">Nikko Loan Agreement</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 29, 2019, </div>the Company and Nikko Chemicals Co., Ltd. (Nikko) entered into a loan agreement (the Nikko Loan Agreement) to make available to the Company secured loans in an aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.0</div> million, to be issued in separate installments of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.0</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.0</div> million, respectively, with each installment being subject to certain closing conditions, including the entry into certain commercial agreements and other arrangements relating to the Aprinnova JV (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> &#x201c;Related Party Transactions&#x201d;). On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 30, 2019, </div>the Company borrowed the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> installment of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.0</div> million under the Nikko Loan Agreement and received net cash proceeds of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.8</div> million, with the remaining <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.2</div> million being withheld by Nikko as prepayment of the interest payable on such loan through the maturity date. On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 8, 2019, </div>the Company borrowed the remaining <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.0</div> million available under the Nikko Loan Agreement and received net cash proceeds of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.9</div> million, with the remaining <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.1</div> million being withheld by Nikko as prepayment of the interest payable on such loan through the maturity date. The loans (i) mature on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 18, 2020, (</div>ii) accrue interest at a rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5%</div> per annum from and including the applicable loan date through the maturity date, which interest is required to be prepaid in full on the date of the applicable loan, and (iii) are secured by a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div>-priority lien on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12.8%</div> of the Aprinnova JV interests owned by the Company.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"><div style="display: inline; font-style: italic;">Aprinnova Working Capital Loan</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Effective <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 31, 2019, </div>the Company and Nikko agreed to extend the term of the Second Aprinnova Note (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> &#x201c;Debt&#x201d; in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> Form <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div>-K/A) from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 1, 2019 </div>to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 1, 2020.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"><div style="display: inline; font-style: italic;">Naxyris Loan and Security Agreement</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">On&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 14, 2019, </div>the Company, certain of the Company&#x2019;s subsidiaries (the Subsidiary Guarantors) and, as lender, Naxyris, an existing stockholder of the Company and an investment vehicle owned by Naxos Capital Partners SCA Sicar, which is affiliated with NAXOS S.A.R.L. (Switzerland), for which director Carole Piwnica serves as director, entered into a Loan and Security Agreement (the Naxyris Loan Agreement) to make available to the Company a secured term loan facility in an aggregate principal amount of up to&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$10,435,000</div>&nbsp;(the Naxyris Loan Facility), which the Company borrowed in full on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 14, 2019.</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">Loans under the Naxyris Loan Facility have a maturity date of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 1, 2022 </div>and accrue interest at a rate per annum equal to the greater of (i) <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12%</div> or (ii) the rate of interest payable with respect to any indebtedness of the Company plus <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25</div> basis points, which interest will be payable monthly in arrears, provided that all interest accruing from and after <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 14, 2019 </div>through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 1, 2019 </div>shall be due and payable on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 15, 2019.</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">The obligations of the Company under the Naxyris Loan Facility are (i) guaranteed by the Subsidiary Guarantors and (ii) secured by a perfected security interest in substantially all of the assets of the Company and the Subsidiary Guarantors (the Collateral), junior in payment priority to Foris Ventures subject to certain limitations and exceptions, as well as the terms of the Intercreditor Agreement (as defined above).</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 27pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">Mandatory prepayments of the outstanding amounts under the Naxyris Loan Facility will be required upon the occurrence of certain events, including asset sales, a change in control, and the incurrence of additional indebtedness, subject to certain exceptions and reinvestment rights.&nbsp;Outstanding amounts under the Naxyris Loan Facility must also be prepaid to the extent that the borrowing base exceeds the outstanding principal amount of the loans under the Naxyris Loan Facility. In addition, the Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>at its option prepay the outstanding principal amount of the loans under the Naxyris Loan Facility in full before the maturity date. Any prepayment of the loans under the Naxyris Loan Facility prior to the maturity date, whether pursuant to a mandatory or optional prepayment, is subject to a prepayment charge equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> year&#x2019;s interest at the then-current interest rate for the Naxyris Loan Facility. Upon the repayment of the loans under the Naxyris loan facility, whether on the maturity date or earlier pursuant to an optional or mandatory prepayment, the Company will pay Naxyris an end of term fee. In addition, (i) the Company will be required to pay a fee equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> of any amount the Company fails to pay within <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> business days of its due date and (ii) any interest that is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> paid when due will be added to principal and will bear compound interest at the applicable rate.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</div> <!-- Field: Page; Sequence: 32; Value: 4 --> <!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">The affirmative and negative covenants in the Naxyris Loan Agreement relate to, among other items: (i) payment of taxes; (ii) financial reporting; (iii) maintenance of insurance; and (iv) limitations on indebtedness, liens, mergers, consolidations and acquisitions, transfers of assets, dividends and other distributions in respect of capital stock, investments, loans and advances, and corporate changes. The Naxyris Loan Agreement also contains financial covenants, including covenants related to minimum revenue, liquidity, and asset coverage.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 2019 </div>Credit Agreements</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 10, 2019, </div>the Company entered into separate credit agreements (the &#x201c;Investor Credit Agreements&#x201d;) with each of Schottenfeld Opportunities Fund II, L.P., Phase Five Partners, LP and Koyote Trading, LLC (the &#x201c;Investors&#x201d;) to make available to the Company unsecured credit facilities in an aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$12.5</div> million, which the Company borrowed in full on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 10, 2019 </div>and issued to the Investors separate promissory notes in the aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$12.5</div> million (the &#x201c;Investor Notes&#x201d;). Each Investor Note (i) accrues interest at a rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12%</div> per annum from and including <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 10, 2019, </div>which interest is payable quarterly in arrears on each <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 31, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 30, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 30 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, </div>beginning <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2019, </div>and (ii) matures on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2023. </div>The Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>at its option repay the amounts outstanding under the Investor Notes before the maturity date, in whole or in part, at a price equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100%</div> of the amount being repaid plus accrued and unpaid interest on such amount to the date of repayment.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">In connection with the entry into the Investor Credit Agreements, on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 10, 2019, </div>the Company issued to the Investors warrants to purchase up to an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,205,128</div> shares of Common Stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.90</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance in a private placement pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div>) of the Securities Act and Regulation D promulgated under the Securities Act. The exercise price of the warrants is subject to standard adjustments but does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> contain any anti-dilution protection, and the warrants only permit &#x201c;cashless&#x201d; or &#x201c;net&#x201d; exercise after the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">six</div>-month anniversary of issuance of the applicable warrant, and only to the extent that there is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> Investor <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>exercise its warrant to the extent that, after giving effect to such exercise, such Investor, together with its affiliates, would beneficially own in excess of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9.99%</div> of the number of shares of common stock outstanding after giving effect to such exercise. In addition, the Company agreed to file a registration statement providing for the resale by the Investors of the shares of Common Stock underlying the warrants with the SEC within <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60</div> days following the date of the issuance of the warrants and to use commercially reasonable efforts to (i) cause such registration statement to become effective within <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">120</div> days following the date of the issuance of the warrants and (ii) keep such registration statement effective until the Investors <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> longer beneficially own any such shares of Common Stock or such shares of Common Stock are eligible for resale under Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144</div> under the Securities Act without regard to volume limitations. If the Company fails to file the registration statement by the filing deadline or the registration statement is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> declared effective by the effectiveness deadline, or the Company fails to maintain the effectiveness of the registration statement as required by the warrants, then the exercise price of the warrants will be reduced by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10%,</div> and by an additional <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5%</div> if such failure continues for longer than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">90</div> days, subject to an exercise price floor of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.31</div> per share, provided that upon the cure by the Company of such failure, the exercise price of the warrants will revert to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.90</div> per share.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">In connection with the entry into the Investor Credit Agreements and the issuance of the warrants, on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 10, 2019, </div>the Company and the Investors entered into a Standstill Agreement (the &#x201c;Investor Standstill Agreement&#x201d;), pursuant to which the Investors agreed that, until the earliest to occur of (i) the Investors <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> longer beneficially owning any shares underlying the warrants, (ii) the Company entering into a definitive agreement involving the direct or indirect acquisition of all or a majority of the Company&#x2019;s equity securities or all or substantially all of the Company&#x2019;s assets or (iii) a person or group, with the prior approval of the&nbsp;Company&#x2019;s Board of Directors (the &#x201c;Board&#x201d;), commencing a tender offer for all or a majority of the Company's equity securities,&nbsp;neither the Investors nor any of their respective affiliates will (without the prior written consent of the Board), among other things, (i) acquire any&nbsp;loans, debt securities, equity securities, or assets of the Company or any of its subsidiaries, or rights or options with respect thereto, except that the Investors shall be permitted to (a) purchase the shares underlying the warrants pursuant to the exercise of the warrants and (b)&nbsp;acquire beneficial ownership of up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6.99%</div> of the Common Stock,&nbsp;or (ii) make any proposal, public announcement, solicitation or offer with respect to, or otherwise solicit, seek or offer to effect, or instigate, encourage, or assist any <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">third</div> party with respect to: (a) any business combination, merger, tender offer, exchange offer, or similar transaction involving the Company or any of its subsidiaries; (b) any restructuring, recapitalization, liquidation, or similar transaction involving the Company or any of its subsidiaries; (c) any acquisition of any of the Company&#x2019;s loans, debt securities, equity securities or assets, or rights or options with respect thereto; or (d) any proposal to seek representation on the Board or otherwise seek to control or influence the management, Board, or policies of the Company, in each case subject to certain exceptions.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Ginkgo Note Amendment</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">&nbsp;</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 29, 2019, </div>in connection with Ginkgo granting certain waivers under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2017 </div>Ginkgo Note and the Ginkgo Partnership Agreement (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> &#x201c;Debt&#x201d; and Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> "Revenue Recognition" in Part II, Item <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8</div> of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> Form <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div>-K/A), (i) the Company and Ginkgo amended the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2017 </div>Ginkgo Note to increase the interest rate from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10.5%</div> per annum to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12%</div> per annum, beginning <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 1, 2019 </div>and (ii) the Company agreed to pay Ginkgo a cash waiver fee of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.3</div> million, payable in installments on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 15, 2019 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 31, 2020.</div></div></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2.</div> Balance Sheet Details</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Inventories</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold; white-space: nowrap"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold; padding-bottom: 1pt; white-space: nowrap">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid; white-space: nowrap">March 31, 2019</td> <td style="font-weight: bold; padding-bottom: 1pt; white-space: nowrap">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid; white-space: nowrap">December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 64%; text-align: left">Raw materials</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,451</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,901</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Work-in-process</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">238</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">539</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt">Finished goods</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,797</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,253</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="padding-bottom: 2.5pt; padding-left: 10pt">Inventories</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,486</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,693</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Deferred cost of products sold - related party</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt; white-space: nowrap"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt; white-space: nowrap">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid; white-space: nowrap">March 31, 2019</td> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt; white-space: nowrap">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid; white-space: nowrap">December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 64%; font-size: 10pt; text-align: left">Deferred cost of products sold - related party</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 15%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,489</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 15%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">489</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt">Deferred cost of products sold, noncurrent - related party</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,001</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,828</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; padding-bottom: 2.5pt; text-indent: 10pt">Total</td> <td style="font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,490</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,317</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;"></div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;"></div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018, </div>the Company amended the supply agreement with DSM to secure capacity at the Brotas <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div> facility for sweetener production through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2022.</div> See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> &#x201c;Revenue Recognition&#x201d; in Part II, Item <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8</div> of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> Form <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div>-K/A for information regarding the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018 </div>Supply Agreement Amendment. The supply agreement was included as an element of a combined transaction with DSM, which resulted in a fair value allocation of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$24.4</div> million to the manufacturing capacity fees, of which <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.3</div> million was recorded as deferred cost of products sold at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018. </div>During the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> months ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 31, 2019, </div>the Company paid an additional <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$7.3</div> million of reservation capacity fees, which was recorded as additional deferred cost of products sold. The remaining <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$13.8</div> million capacity fees will be recorded as deferred cost of products sold in the period the additional payments are made to DSM. The deferred cost of products sold asset is expensed to cost of products sold on a units of production basis as the Company's sweetener product is sold over the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">five</div>-year term of the supply agreement. Each quarter, the Company evaluates its future production volumes and adjusts the unit cost to be expensed over the remaining estimated production volume. Due to the Company's commercial launch of the product in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2018, </div>amortization of the deferred cost of products sold asset has been insignificant through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019.</div> The deferred cost of products sold asset is evaluated for recoverability at each period end.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Prepaid expenses and other current assets</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">March 31, 2019</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 64%; text-align: left">Prepayments, advances and deposits</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,310</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,644</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Recoverable taxes from Brazilian government entities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">956</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">631</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="padding-bottom: 1pt">Other</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,949</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,291</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="padding-bottom: 0pt; padding-left: 10pt">Total prepaid expenses and other current assets</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,215</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,566</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Property, Plant and Equipment, Net</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">March 31, 2019</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 64%; text-align: left">Machinery and equipment</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">45,874</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">43,713</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Leasehold improvements</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">39,951</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">39,922</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Computers and software</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,138</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,987</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Furniture and office equipment, vehicles and land</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,279</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,016</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt">Construction in progress</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,460</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,749</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-left: 10pt">Total property, plant and equipment, gross</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100,702</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">98,387</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt">Less: accumulated depreciation and amortization</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(79,144</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(78,631</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt; padding-left: 10pt">Property, plant and equipment, net</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">21,558</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19,756</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">During the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> months ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> the Company capitalized <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.2</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.8</div> million, respectively, of internal labor costs required to automate, integrate and ready certain laboratory and plant equipment for its intended use.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">Depreciation and amortization expense, including amortization of assets under financing leases, was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.8</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.6</div> million for the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> months ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> respectively.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Leases</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Operating Leases</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The Company has entered into operating leases primarily for administrative offices, laboratory equipment and other facilities. The operating leases have remaining terms that range from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div> year to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5</div> years, and often include <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> or more options to renew. These renewal terms can extend the lease term from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div> to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5</div> years and are included in the lease term when it is reasonably certain that the Company will exercise the option. The operating leases are classified as Right-of-use (ROU) assets under operating leases on the Company's <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> Condensed Consolidated Balance Sheet and represent the Company&#x2019;s right to use the underlying asset for the lease term. The Company&#x2019;s obligation to make operating lease payments is included in "Lease liabilities" and "Lease liabilities, net of current portion" on the Company's <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> Condensed Consolidated Balance Sheet. Based on the present value of the lease payments for the remaining lease term of the Company's existing leases, the Company recognized right-of-use assets of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$29.7</div> million and lease liabilities for operating leases of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$33.6</div> million on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2019. </div>Operating lease right-of-use assets and liabilities commencing after <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2019 </div>are recognized at commencement date based on the present value of lease payments over the lease term. As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> total right-of-use assets and operating lease liabilities were <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$27.6</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$29.7</div> million, respectively. All operating lease expense is recognized on a straight-line basis over the lease term. In the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> months ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> the Company recorded <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.8</div> million of operating lease amortization that was charged to expense, and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.8</div> million of operating lease amortization for certain contract manufacturing arrangements that was capitalized to inventory.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Because the rate implicit in each lease is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> readily determinable, the Company uses its incremental borrowing rate to determine the present value of the lease payments. The Company has certain contracts for real estate and marketing which <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>contain lease and non-lease components which it has elected to treat as a single lease component.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Information related to the Company's right-of-use assets and related lease liabilities were as follows:</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; margin-left: 40.5pt; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold"><div style="display: inline; text-decoration: underline;">Amounts in thousands</div></td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Three Months Ended March 31, 2019</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 87%; text-align: left">Cash paid for operating lease liabilities</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,305</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Right-of-use assets obtained in exchange for new operating lease obligations<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(1)</div></td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">30,472</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Weighted-average remaining lease term (in years)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2.7</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Weighted-average discount rate</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18.0</div></td> <td style="text-align: left">%</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 40.5pt; text-align: justify">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 40.5pt; text-align: justify"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 40.5pt">(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div>) Includes&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$29.7</div> million&nbsp;for operating leases existing on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2019 </div>and&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.8</div> million&nbsp;for operating leases that commenced in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> quarter of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019.</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 40.5pt; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Financing Leases</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The Company has entered into financing leases primarily for laboratory and computer equipment. Assets purchased under financing leases are included in "Property, plant and equipment, net" on the condensed consolidated balance sheets. For financing leases, the associated assets are depreciated or amortized over the shorter of the relevant useful life of each asset or the lease term. Property, plant and equipment, net included <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.3</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.0</div> million of machinery and equipment under financing leases as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> respectively. Accumulated amortization of assets under financing leases totaled <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.5</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.3</div> million as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> respectively.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Maturities of Financing and Operating Leases</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Maturities of lease liabilities as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> were as follows:</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold; text-align: left">Years ending December&nbsp;31:<div style="display: inline; text-decoration: underline;"><br /> (In thousands)</div></td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Financing Leases</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Operating<br /> Leases</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Total Leases</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 46%; text-align: left">2019 (remaining nine months)</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">368</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,755</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,123</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2020</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">199</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,109</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,308</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">2021</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,226</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,227</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2022</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,398</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,398</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">2023</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,034</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,034</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Thereafter</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Total lease payments</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">568</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">39,522</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">40,090</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left"><div style=" margin: 0pt 0">Less: amount representing interest</div> </td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(23</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(9,793</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(9,816</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Total lease liability</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">545</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29,729</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">30,274</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Current lease liability</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">452</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,972</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,424</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Noncurrent lease liability</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">93</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,757</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,850</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Total lease liability</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">545</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29,729</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">30,274</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></div><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Other Assets</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; margin-left: 49.5pt; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">March 31, 2019</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 64%; text-align: left">Contingent consideration</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,286</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,286</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Deposits</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">145</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,465</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="padding-bottom: 1pt">Other</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,117</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,207</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt; padding-left: 10pt">Other assets</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,548</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,958</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Accrued and Other Current Liabilities</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; margin-left: 49.5pt; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">March 31, 2019</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">DSM manufacturing capacity fee</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style=" margin: 0pt 0">7,250</div></div> </td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 64%; text-align: left">Contract termination fees</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left"></td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,337</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left"></td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,247</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Accrued interest</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,094</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,853</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Payroll and related expenses</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,285</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,220</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Asset retirement obligation</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,111</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,063</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Tax-related liabilities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,589</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,139</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Professional services</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,871</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,173</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="padding-bottom: 1pt">Other</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,054</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,284</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 2.5pt; padding-left: 10pt">Total accrued and other current liabilities</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">33,591</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28,979</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Other noncurrent liabilities</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; margin-left: 49.5pt; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold; text-align: left"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">March 31, 2019</td> <td style="font-weight: bold; padding-bottom: 1pt; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 64%; text-align: left">Contract termination fees, net of current portion</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,207</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 15%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,715</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Liability for unrecognized tax benefit</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,582</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,582</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Contract liability, net of current portion (Note 9)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,449</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,587</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Deferred rent, net of current portion<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(1)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,440</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="padding-bottom: 1pt">Other</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">682</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">868</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt">Total other noncurrent liabilities</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,920</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,192</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 49.5pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div>)&nbsp;&nbsp;&nbsp;&nbsp; </div>Deferred rent at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018 </div>was reclassified to ROU asset upon the adoption on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2019 </div>of ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">842,</div> "Leases".</div></div> 2589000 2139000 5000000 5000000 5000000 5000000 -2430000 -7504000 -2039000 -58357000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><!-- Field: /Page --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"><div style="display: inline; font-weight: bold;">Use of Estimates and Judgements</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates, judgements and assumptions that affect the reported amounts of assets and liabilities, disclosures of contingent assets and liabilities at the date of the condensed consolidated financial statements, and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates, and such differences <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be material to the condensed consolidated financial statements.</div></div></div></div></div></div> P2Y P2Y P2Y P2Y P2Y P2Y 77512059 51200922 77512059 51200922 Includes $26.7 million for operating leases existing on January 1, 2019 and $0.9 million for operating leases that commenced in the first quarter of 2019. As of March 31, 2019 and December 31, 2018, contract liabilities, noncurrent is presented in Other Noncurrent Liabilities in the consolidated balance sheets because of its insignificance. The potentially dilutive effect of convertible promissory notes was computed based on conversion ratios in effect as of the respective period end dates. A portion of the convertible promissory notes issued carries a provision for a reduction in conversion price under certain circumstances, which could potentially increase the dilutive shares outstanding. 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Other us-gaap_OtherAssetsMiscellaneousNoncurrent Current assets: Accounting Standards Update 2017-11 [Member] Schedule of Other Assets, Noncurrent [Table Text Block] us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents Cash, cash equivalents and restricted cash at beginning of period Cash, cash equivalents and restricted cash at end of the period Mezzanine Equity us-gaap_ContractWithCustomerAssetReclassifiedToReceivable Contract with Customer, Asset, Reclassified to Receivable Liability for unrecognized tax benefit us-gaap_DeferredTaxLiabilitiesGrossNoncurrent Private Placement [Member] us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect Net decrease in cash, cash equivalents and restricted cash us-gaap_ContractWithCustomerAssetCumulativeCatchUpAdjustmentToRevenueChangeInEstimateOfTransactionPrice Contract with Customer, Asset, Cumulative Catch-up Adjustment to Revenue, Change in Estimate of Transaction Price us-gaap_Liabilities Liabilities, Total Total liabilities us-gaap_NetCashProvidedByUsedInFinancingActivities Net cash used in financing activities Commitments and contingencies (Note 8) Sale of Stock [Axis] Sale of Stock [Domain] Effect of exchange rate changes on cash, cash equivalents and restricted cash Loans Payable and Credit Facilities [Member] Related to both loans payable and credit facilities. Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Table Text Block] us-gaap_OperatingIncomeLoss Loss from operations us-gaap_NetCashProvidedByUsedInOperatingActivities Net cash used in operating activities Prepaid expenses and other current assets Total prepaid expenses and other current assets us-gaap_NetCashProvidedByUsedInInvestingActivities Net cash used in investing activities Related Party Loans Payable and Credit Facilities [Member] Related to related party loans payable and credit facilities. Cost of products sold Cost of Goods and Services Sold, Total Base Rate [Member] Counterparty Name [Axis] amrs_RevenueRemainingPerformanceObligationConstrainedVariableConsiderationAmount Revenue, Remaining Performance Obligation, Constrained Variable Consideration, Amount Amount of transaction price allocated to performance obligation that has not been recognized as revenue and represents a constrained variable consideration. Counterparty Name [Domain] Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block] Accounting Standards Update 2014-09 [Member] amrs_ResearchAndDevelopmentObligationRemainingAmount Research and Development Obligation, Remaining Amount The remaining amount of research and development obligation. Financing of equipment The amount of equipment financed under financing leases. Cumulative effect of change in accounting principle for ASU 2017-11 (Note 2) The amount of cumulative effect adjustment due to a new accounting policy. Accounting Standards Update 2016-02 [Member] June Foris Credit Agreement [Member] Information pertaining to the June Foris Credit Agreement, entered into on June 11, 2019. April Foris Credit Agreement [Member] Information pertaining to the April Foris Credit Agreement, entered into on April 8, 2019. Loan and Security Agreement Amendment and Waiver [Member] Represents information pertaining to the Loan and Security Agreement Amendment and Waiver. Mezzanine Equity Table [Table Text Block] Tabular disclosure of mezzanine equity. July Foris Credit Agreement [Member] Information pertaining to the July Foris Credit Agreement, entered into on July 10, 2019. Other Loans Payable [Member] Represents other loans payable. Type of Adoption [Domain] Aprinnova JV [Member] Represents information pertaining to Aprinnova, LLC, a joint venture. us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation Payment of minimum employee taxes withheld upon net share settlement of restricted stock units Net Balance amrs_LongtermDebtExcludingCurrentMaturitiesIncludingDueToRelatedParties Amount after unamortized (discount) premium and debt issuance costs of long-term debt classified as noncurrent, including due to related parties and excluding amounts to be repaid within one year or the normal operating cycle, if longer. Includes, but not limited to, notes payable, bonds payable, debentures, mortgage loans and commercial paper. Excludes capital lease obligations. amrs_LongtermDebtCurrentMaturitiesIncludingDueToRelatedParties Long-term Debt, Current Maturities, Including Due to Related Parties Net Balance Amount, after unamortized (discount) premium and debt issuance costs, of long-term debt, classified as current including due to related parties. Includes, but not limited to, notes payable, bonds payable, debentures, mortgage loans and commercial paper. Excludes capital lease obligations. Contract termination fees The amount of contract termination fees payable classified as current. Adjustments for New Accounting Pronouncements [Axis] Contract termination fees, net of current portion amrs_ContractTerminationFeesNoncurrent The amount of contract termination fees classified as noncurrent. Mezzanine Equity Disclosure [Text Block] The entire disclosure of mezzanine equity. The 2015 144A Notes [Member] Information pertaining to the 2015 144A Notes. The 2014 144A Notes [Member] Information pertaining to the 2014 144A Notes. August Foris Credit Agreement [Member] Information pertaining to the August Foris Credit Agreement entered into on August 28, 2019. us-gaap_CostsAndExpenses Total cost and operating expenses Issuance of common stock upon exercise of warrants Amount of increase in additional paid in capital (APIC) resulting from the exercise of warrants. DSM International B.V. [Member] Represents information pertaining to DSM International B.V. Foris Credit Agreements [Member] Information pertaining to the Foris Credit Agreements which is comprised of the April, June, and July Foris credit agreements. Issuance of common stock upon exercise of warrants (in shares) Stock Issued During Period, Shares, Warrants Exercised Exercises (in shares) Number of shares issued during the period as a result of exercise of warrants. Noncontrolling Interest [Member] amrs_ClassOfWarrantOrRightStockOwnershipPercentageRestrictionOnAbilityToExercise Class of Warrant or Right, Stock Ownership Percentage, Restriction on Ability to Exercise Represents a restriction on the exercise of warrants or rights in which the exercise of warrants or rights would result in beneficial ownership of an equal or greater percentage of a specified threshold of stock in the Company. Cost and operating expenses: Additional Warrants Issued (in shares) The number of warrants or rights issued during the reporting period. Scenario [Domain] Proceeds from exercises of warrants Proceeds from Warrant Exercises Forecast [Member] Other Non-affiliated Investors [Member] Represents certain other non-affiliated investors. Proceeds from issuance of common stock in private placements, net of issuance costs Retained Earnings [Member] Proceeds from exercises of common stock options Private Placement, April 26, 2019 [Member] Represents the private placement which took place on April 26, 2019. us-gaap_ProceedsFromIssuanceOfCommonStock Proceeds from Issuance of Common Stock Period-end Preferred Stock [Member] Preferred shares may provide a preferential dividend to the dividend on common stock and may take precedence over common stock in the event of a liquidation. Preferred shares typically represent an ownership interest in the company. Private Placement, April 16, 2019 [Member] Represents the private placement which took place on April 16, 2019. Scenario [Axis] Additional Paid-in Capital [Member] Private Placement May 3, 2019 [Member] Represents private placement on may 3, 2019. Private Placement April 29, 2019 [Member] Represents the private placement on April 29, 2019. Common Stock [Member] amrs_WarrantExerciseBeneficialCommonStockOwnershipMaximumPercentage Warrant Exercise, Beneficial Common Stock Ownership Maximum Percentage The maximum percentage of beneficial common stock ownership under warrant exercises. Preferred Stock [Member] LSA Amendment Warrants [Member] Represents warrants issued in connection with LSA Amendment. The 2019 DSM Credit Agreement, Second Installment [Member] Represents information pertaining to the second installment of the "2019 DSM Credit Agreement" entered into on September 17, 2019. The 2019 DSM Credit Agreement, First Installment [Member] Represents information pertaining to the first installment of the "2019 DSM Credit Agreement" entered into on September 17, 2019. The 2019 DSM Credit Agreement [Member] Represents information pertaining to the "2019 DSM Credit Agreement" entered into on September 17, 2019. Equity Components [Axis] amrs_ConsiderationTransferredCashAmount Consideration Transferred, Cash Amount The amount of the cash portion of the consideration transferred in accordance to certain agreements. Equity Component [Domain] Raizen Energia S.A. [Member] Represents Raizen Energia S.A. (Raizen). amrs_ProceedsFromSaleOfEquitySecuritiesGrossTriggerRepaymentOfAmountsOutstandingUnderLineOfCredit Proceeds from Sale of Equity Securities, Gross, Trigger Repayment of Amounts Outstanding Under Line of Credit The minimum amount of gross cash proceeds from one or more sales of equity securities which would trigger a required repayment of any amounts outstanding under a line of credit. Net Balance us-gaap_LongTermDebt Long-term Debt, Total amrs_DebtInstrumentRepaymentPricePercentOfFaceAmount Debt Instrument, Repayment Price, Percent of Face Amount The repayment price, as a percent of face value, of the debt instrument excluding any accrued and unpaid interest. The 2019 DSM Credit Agreement, Third Installment [Member] Represents information pertaining to the third installment of the "2019 DSM Credit Agreement" entered into on September 17, 2019. Maxwell (Mauritius) Pte Ltd [Member] Represents Maxwell (Mauritius) Pte Ltd. us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1 Class of Warrant or Right, Exercise Price of Warrants or Rights us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1 Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period Warrants Issued for 2014 Rule 144A Convertible Notes Exchanges [Member] Represents warrants issued for 2014 Rule 144A convertible notes exchanges. Class of Warrant or Right [Axis] amrs_DebtConversionConvertedInstrumentWarrantsIssued Debt Conversion, Converted Instrument, Warrants Issued Represents the number of warrants issued in exchange for the original debt being converted in a noncash (or part noncash) transaction. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or payments in the period. us-gaap_RevenueRemainingPerformanceObligation Revenue, Remaining Performance Obligation, Amount Class of Warrant or Right [Domain] amrs_CapitalContributionToTheJointVenture Capital Contribution to the Joint Venture The cash outflow associated with a capital contribution to a joint venture. Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis] Warrants Issued in Exchange for 6% Convertible Notes Due 2021 [Member] Represents warrants issued in exchange for 6% convertible notes due 2021. us-gaap_ClassOfWarrantOrRightOutstanding Number outstanding, beginning balance (in shares) Number outstanding, ending balance (in shares) Warrants Issued in Exchange for Convertible Senior Notes, 6.0% Due 2021, Second Exchange [Member] Represents warrants issued in exchange for 6.0% convertible senior notes due 2021 issued in the "Second Exchange" on July 24, 2019. Convertible Senior Notes, 6.0%, Due in 2021, Second Exchange [Member] Represents the 6.0% convertible senior notes due 2021 issued in the "Second Exchange" on July 24, 2019. us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights Class of Warrant or Right, Number of Securities Called by Warrants or Rights Nikko Loan Agreement, Second Installment [Member] Represents the second installment of the Nikko Loan Agreement. Nikko Loan Agreement, First Installment [Member] Represents the first installment of the Nikko Loan Agreement. Nikko Loan Agreement [Member] Information pertaining to the Nikko Loan Agreement. amrs_DebtInstrumentPenaltyForFailureToMakePaymentPremiumIncreasePercentage Debt Instrument, Penalty for Failure to Make Payment, Premium Increase Percentage Represents the percent increase in the face amount of the debt instrument as a result of a failure to make an installment payment. Fixed Assets From Sao Martinho S.A. [Member] Related to fixed assets from Sao Martinho S.A. Fixed Assets Owned by the Company [Member] Related to fixed assets owned by the company. Contract liability, net of current portion (Note 9) us-gaap_DeferredRevenueNoncurrent amrs_FirstPriorityLienOnInterestsOwnedByTheCompany First Priority Lien on Interests Owned by the Company The percent of interest owned by the company in another entity which secure a first-priority lien. amrs_ProceedsFromIssuanceOfLongtermDebtWithheldAsPrepaymentOfInterestPayable Proceeds from Issuance of Long-term Debt, Withheld as Prepayment of Interest Payable Represents the amount of proceeds from an issuance of long-term debt which are being withheld as prepayment of interest payable. Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Table Text Block] The Investors [Member] Related to the investors. us-gaap_LineOfCredit Long-term Line of Credit, Total amrs_DebtInstrumentFailureToPayFee Debt Instrument, Failure to Pay Fee The percent of the failure to pay fee for a debt instrument. Interest Wtih Respect to Indebtedness [Member] Related to the interest with respect to indebtedness. The Naxyris Loan Agreement [Member] Related to the Naxyris Loan Agreement. amrs_WarrantsOrRightsOutstandingReductionInExercisePrice Warrants or Rights Outstanding, Reduction in Exercise Price The amount of reduction in exercise price of warrants or rights outstanding. amrs_WarrantsOrRightsOutstandingMaximumPercentOfCommonStockOutstanding Warrants or Rights Outstanding, Maximum Percent of Common Stock Outstanding The maximum percent of common stock outstanding allowed to be held by holders of the warrants or rights. Investor Warrants [Member] Related to investor warrants. The Investor Notes [Member] Related to the investor notes. us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net, Total amrs_WarrantsOrRightsOutstandingAdditionalReductionInExercisePrice Warrants or Rights Outstanding, Additional Reduction in Exercise Price The percentage of additional reduction in exercise price for warrants or rights outstanding. Disaggregation of Revenue [Table Text Block] Deferred cost of products sold - related party Deferred cost of products sold - related party The amount due from related parties for deferred cost of products sold. us-gaap_RepaymentsOfLongTermDebt Principal payments on debt Lease liabilities, net of current portion (Note 2) Noncurrent lease liability, total leases Present value of lessee's discounted obligation for lease payments from operating and finance leases, classified as noncurrent. us-gaap_RepaymentsOfLongTermCapitalLeaseObligations Principal payments on financing leases Lease liabilities (Note 2) Current lease liability, total leases Present value of lessee's discounted obligation for lease payments from operating and financing leases, classified as current. Machinery and Equipment [Member] us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet Unamortized Debt Premium Balance Sheet Location [Axis] Property, Plant and Equipment, Net [Member] Represents property, plant and equipment, net. amrs_LesseeOperatingLeaseRemainingLeaseTerm Lessee Operating Lease, Remaining Lease Term Remaining term of lessee's operating lease. Balance Sheet Location [Domain] Lease liabilities Amount of increase (decrease) in operating and finance lease liabilities. Principal us-gaap_DebtInstrumentCarryingAmount Long-term Debt, Gross Lessee, Lease Liability, Maturity [Table Text Block] Tabular disclosure of undiscounted cash flows of operating and finance lease liability. Accounting Policies [Abstract] Significant Accounting Policies [Text Block] amrs_FinanceLeaseRightofuseAssetAccumulatedAmortization Finance Lease, Right-of-use Asset, Accumulated Amortization Amount of accumulated amortization attributable to right-of-use asset from finance lease. 2020, total leases Amount of lessee's undiscounted obligation for lease payments for lease, due in second fiscal year following latest fiscal year. 2019 (remaining nine months), total leases Amount of lessee's undiscounted obligation for lease payments for lease, due in remainder of fiscal year following latest fiscal year ended. Selling, General and Administrative Expenses [Member] Total lease liability, total leases Present value of lessee's discounted obligation for lease payments from operating and finance leases. Thereafter, total leases Amount of lessee's undiscounted obligation for lease payments for lease, due after fifth fiscal year following latest fiscal year. 2023, total leases Amount of lessee's undiscounted obligation for lease payments for lease, due in fifth fiscal year following latest fiscal year. 2022, total leases Amount of lessee's undiscounted obligation for lease payments for lease, due in fourth fiscal year following latest fiscal year. 2021, total leases Amount of lessee's undiscounted obligation for lease payments for lease, due in third fiscal year following latest fiscal year. us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption Cumulative effect of change in accounting principle Debt Securities [Member] amrs_LeaseLiabilityUndiscountedExcessAmount Less: amount representing interest Amount of lessee's undiscounted obligation for lease payments in excess of discounted obligation for lease payments. Title of 12(b) Security amrs_LeaseLiabilityPaymentDue Total lease payments, total leases Amount of lessee's undiscounted obligation for lease payments for lease. Right-of-use assets obtained in exchange for new operating lease obligations(1) Amount of right-of-use asset obtained in exchange for new operating lease liability and due to adoption of new accounting principle. us-gaap_ProceedsFromIssuanceOfLongTermDebt Proceeds from Issuance of Long-term Debt, Total Cost of Sales [Member] Research and Development Expense [Member] Income Statement Location [Axis] Second Aprinnova Note [Member] Related to second aprinnova note. Income Statement Location [Domain] Collaborative Arrangement and Arrangement Other than Collaborative [Axis] Collaborative Arrangement Disclosure [Text Block] Novvi LLC [Member] Investee by the name of Novvi LLC. amrs_LineOfCreditFacilityIncrementalDrawDownAmount Line of Credit Facility, Incremental Draw Down Amount Represents the line of credit facility, incremental draw down amount. Other us-gaap_AccruedRentNoncurrent Weighted-average shares of common stock outstanding used in computing loss per share of common stock, basic and diluted (in shares) us-gaap_SharePrice Share Price Antidilutive securities (in shares) Weighted-average shares of common stock outstanding used in computing loss per share of common stock, basic and diluted (in shares) us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding Loss per share attributable to common stockholders, basic and diluted (in dollars per share) Loss per share attributable to common stockholders, basic and diluted (in dollars per share) Statement [Table] Statement of Financial Position [Abstract] Contract with Customer, Asset and Liability [Table Text Block] Warrants Issued in Exchange for August 2013 Financing Convertible Note [Member] Represents the warrants issued in exchange of the August 2013 Financing Convertible Note. Statement of Cash Flows [Abstract] Statement of Stockholders' Equity [Abstract] Income Statement [Abstract] Proceeds from issuance of debt, net of issuance costs us-gaap_RepaymentsOfDebt Repayments of Debt Other Noncurrent Liabilities [Table Text Block] Asset retirement obligation us-gaap_FinanceLeaseLiabilityPaymentsDue Total lease payments, financing leases 2023, financing leases Thereafter, financing leases us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount Less: amount representing interest amrs_LongTermDebtCurrentMaturitiesDueWithin60DaysIncludingDueToRelatedPartiesAnticipatedInterestPortion Long-term Debt, Current Maturities Due Within 60 Days, Including Due to Related Parties, Anticipated Interest Portion Represents the anticipated interest portion of the amount due within 60 days, after unamortized (discount) premium and debt issuance costs, of long-term debt, classified as current including due to related parties. Includes, but not limited to, notes payable, bonds payable, debentures, mortgage loans and commercial paper. Excludes capital lease obligations. 2020, financing leases 2021, financing leases 2022, financing leases 2019 (remaining nine months), financing leases amrs_StockIssuedDuringPeriodSharesWarrantsExercisedThroughNetShareSettlement Stock Issued During Period, Shares, Warrants Exercised Through Net Share Settlement Number of shares issued during the period as a result of warrants exercised through net share settlement. Financing activities Accounts receivable, net us-gaap_AccountsReceivableRelatedParties Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] Other noncurrent liabilities Total other noncurrent liabilities Related party debt, net of current portion Accounts receivable, related party, allowance A valuation allowance for trade and other receivables due to an Entity from related parties within one year (or the normal operating cycle, whichever is longer) that are expected to be uncollectible. Gates Foundation Purchase Agreement [Member] A security purchase agreement with the Gates Foundation. Vested or expected to vest (in shares) Represents the number of equity instruments, other than options, that are expected to vest after the balance sheet date. Vested or expected to vest, weighted average grant-date fair value (in dollars per share) Represents the weighted average grant date fair value of equity options, other than options, expected to vest. amrs_CompoundAnnualReturn Compound Annual Return The rate of annual return added on the redemption base price when the Company redeems its stock. Derivative liabilities us-gaap_DerivativeLiabilitiesNoncurrent us-gaap_AccountsReceivableRelatedPartiesCurrent Accounts receivable - related party, net Vested or expected to vest, weighted average remaining contractual life (Year) Weighted average remaining contractual term for fully vested and expected to vest equity instruments other than options outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. amrs_WorkingCapital Working Capital Represents the difference between the company's current assets and current liabilities. Long-term Debt [Member] Period-end Common Stock Warrants [Member] Represents information pertaining to period-end common stock warrants. Other Area [Member] Represents the other geographic area. us-gaap_ContractWithCustomerLiabilityNoncurrent Contract liabilities, noncurrent(1) us-gaap_StockholdersEquity Total Amyris, Inc. stockholders’ deficit Deferred rent, net of current portion(1) us-gaap_CapitalLeaseObligationsNoncurrent Class of Stock [Axis] Class of Stock [Domain] Long-term debt, net of current portion us-gaap_LongTermDebtNoncurrent Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Convertible Promissory Notes [Member] Information related to convertible promissory notes. Stock Options to Purchase Common Stock [Member] Information related to stock options to purchase common stock. EX-101.PRE 11 amrs-20190331_pre.xml XBRL PRESENTATION FILE XML 12 R18.htm IDEA: XBRL DOCUMENT v3.19.3
Note 10 - Related Party Transactions
3 Months Ended
Mar. 31, 2019
Notes to Financial Statements  
Related Party Transactions Disclosure [Text Block]
10.
Related Party Transactions
 
Related Party Debt
 
See
Note
4,
"Debt" above for related party debt
as of
March 
31,
2019
and
December 
31,
2018.
 
Related Party Accounts Receivable and Unbilled Receivables
 
Related party accounts receivable and unbilled receivables as of
March 
31,
2019
and
December 
31,
2018
were as follows:
 
(In thousands)   March 31, 2019   December 31, 2018
Accounts receivable:                
DSM   $
1,334
    $
1,071
 
Novvi    
     
188
 
Total    
     
90
 
    $
1,334
    $
1,349
 
Accounts receivable, unbilled, current:                
DSM   $
    $
8,021
 
Accounts receivable, unbilled, noncurrent:                
DSM   $
1,203
    $
1,203
 
 
Related Party Joint Ventures
 
The Company holds a
50%
interest in the Aprinnova joint venture for business-to-business sales of cosmetic ingredients. This joint venture is consolidated in the accompanying condensed consolidated financial statements.
XML 13 R7.htm IDEA: XBRL DOCUMENT v3.19.3
Condensed Consolidated Statements of Stockholders' Deficit and Mezzanine Equity (Unaudited) - USD ($)
$ in Thousands
Preferred Stock [Member]
Common Stock [Member]
Additional Paid-in Capital [Member]
AOCI Attributable to Parent [Member]
Retained Earnings [Member]
Noncontrolling Interest [Member]
Mezzanine Equity, Common Stock [Member]
Total
Balance (in shares) at Dec. 31, 2017 22,171 45,637,433            
Balance at Dec. 31, 2017 $ 5 $ 1,114,546 $ (42,156) $ (1,290,420) $ 937 $ 5,000 $ (217,088)
Cumulative effect of change in accounting principle (Accounting Standards Update 2014-09 [Member]) at Dec. 31, 2017 (803) (803)
Issuance of common stock upon exercise of warrants (in shares) 162,392            
Issuance of common stock upon exercise of warrants 835 835
Issuance of common stock upon exercise of stock options (in shares) 7,004            
Issuance of common stock upon exercise of stock options 81 81
Issuance of common stock and payment of minimum employee taxes withheld upon net share settlement of restricted stock (in shares) 30,489            
Issuance of common stock and payment of minimum employee taxes withheld upon net share settlement of restricted stock (66) (66)
Stock-based compensation 1,278 1,278
Foreign currency translation adjustment (137) (137)
Net loss (92,802) (92,802)
Issuance for private placement, net (in shares) 13,529            
Issuance for private placement, net 92 92
Other 93 93
Balance (in shares) at Mar. 31, 2018 22,171 45,850,847            
Balance at Mar. 31, 2018 $ 5 1,116,859 (42,293) (1,384,025) 937 5,000 $ (308,517)
Balance (in shares) at Dec. 31, 2018 14,656 76,564,829           76,564,829
Balance at Dec. 31, 2018 $ 8 1,346,996 (43,343) (1,521,417) 937 5,000 $ (216,819)
Cumulative effect of change in accounting principle (Accounting Standards Update 2017-11 [Member]) at Dec. 31, 2018 32,512 8,531 $ 41,043
Issuance of common stock upon exercise of warrants (in shares) 450,568           479,751
Issuance of common stock upon exercise of warrants 1 $ 1
Issuance of common stock upon exercise of stock options (in shares) 3,612           3,612
Issuance of common stock upon exercise of stock options 13 $ 13
Issuance of common stock and payment of minimum employee taxes withheld upon net share settlement of restricted stock (in shares) 191,672            
Issuance of common stock and payment of minimum employee taxes withheld upon net share settlement of restricted stock (9) (9)
Stock-based compensation 3,452 3,452
Fair value of bifurcated embedded conversion feature in connection with debt modification 398 398
Foreign currency translation adjustment 964 964
Net loss (66,243) (66,243)
Balance (in shares) at Mar. 31, 2019 14,656 77,210,681            
Balance at Mar. 31, 2019 $ 8 $ 1,383,363 $ (42,379) $ (1,579,129) $ 937 $ 5,000 $ (237,200)
XML 14 R10.htm IDEA: XBRL DOCUMENT v3.19.3
Note 2 - Balance Sheet Details
3 Months Ended
Mar. 31, 2019
Notes to Financial Statements  
Supplemental Balance Sheet Disclosures [Text Block]
2.
Balance Sheet Details
 
Inventories
 
(In thousands)
  March 31, 2019   December 31, 2018
Raw materials   $
2,451
    $
3,901
 
Work-in-process    
238
     
539
 
Finished goods    
5,797
     
5,253
 
Inventories   $
8,486
    $
9,693
 
 
Deferred cost of products sold - related party
 
(In thousands)
  March 31, 2019   December 31, 2018
Deferred cost of products sold - related party   $
1,489
    $
489
 
Deferred cost of products sold, noncurrent - related party    
9,001
     
2,828
 
Total   $
10,490
    $
3,317
 
 
In
November 2018,
the Company amended the supply agreement with DSM to secure capacity at the Brotas
1
facility for sweetener production through
2022.
See Note
10,
“Revenue Recognition” in Part II, Item
8
of the
2018
Form
10
-K/A for information regarding the
November 2018
Supply Agreement Amendment. The supply agreement was included as an element of a combined transaction with DSM, which resulted in a fair value allocation of
$24.4
million to the manufacturing capacity fees, of which
$3.3
million was recorded as deferred cost of products sold at
December 31, 2018.
During the
three
months ended
March 31, 2019,
the Company paid an additional
$7.3
million of reservation capacity fees, which was recorded as additional deferred cost of products sold. The remaining
$13.8
million capacity fees will be recorded as deferred cost of products sold in the period the additional payments are made to DSM. The deferred cost of products sold asset is expensed to cost of products sold on a units of production basis as the Company's sweetener product is sold over the
five
-year term of the supply agreement. Each quarter, the Company evaluates its future production volumes and adjusts the unit cost to be expensed over the remaining estimated production volume. Due to the Company's commercial launch of the product in
December 2018,
amortization of the deferred cost of products sold asset has been insignificant through
March 
31,
2019.
The deferred cost of products sold asset is evaluated for recoverability at each period end.
 
Prepaid expenses and other current assets
 
(In thousands)
  March 31, 2019   December 31, 2018
Prepayments, advances and deposits   $
3,310
    $
5,644
 
Recoverable taxes from Brazilian government entities    
956
     
631
 
Other    
3,949
     
4,291
 
Total prepaid expenses and other current assets   $
8,215
    $
10,566
 
 
Property, Plant and Equipment, Net
 
(In thousands)
  March 31, 2019   December 31, 2018
Machinery and equipment   $
45,874
    $
43,713
 
Leasehold improvements    
39,951
     
39,922
 
Computers and software    
10,138
     
9,987
 
Furniture and office equipment, vehicles and land    
3,279
     
3,016
 
Construction in progress    
1,460
     
1,749
 
Total property, plant and equipment, gross    
100,702
     
98,387
 
Less: accumulated depreciation and amortization    
(79,144
)    
(78,631
)
Property, plant and equipment, net   $
21,558
    $
19,756
 
 
During the
three
months ended
March 
31,
2019
and
2018,
the Company capitalized
$0.2
million and
$0.8
million, respectively, of internal labor costs required to automate, integrate and ready certain laboratory and plant equipment for its intended use.
 
Depreciation and amortization expense, including amortization of assets under financing leases, was
$0.8
million and
$1.6
million for the
three
months ended
March 
31,
2019
and
2018,
respectively.
 
Leases
 
Operating Leases
 
The Company has entered into operating leases primarily for administrative offices, laboratory equipment and other facilities. The operating leases have remaining terms that range from
1
year to
5
years, and often include
one
or more options to renew. These renewal terms can extend the lease term from
1
to
5
years and are included in the lease term when it is reasonably certain that the Company will exercise the option. The operating leases are classified as Right-of-use (ROU) assets under operating leases on the Company's
March 
31,
2019
Condensed Consolidated Balance Sheet and represent the Company’s right to use the underlying asset for the lease term. The Company’s obligation to make operating lease payments is included in "Lease liabilities" and "Lease liabilities, net of current portion" on the Company's
March 
31,
2019
Condensed Consolidated Balance Sheet. Based on the present value of the lease payments for the remaining lease term of the Company's existing leases, the Company recognized right-of-use assets of
$29.7
million and lease liabilities for operating leases of
$33.6
million on
January 1, 2019.
Operating lease right-of-use assets and liabilities commencing after
January 1, 2019
are recognized at commencement date based on the present value of lease payments over the lease term. As of
March 
31,
2019,
total right-of-use assets and operating lease liabilities were
$27.6
million and
$29.7
million, respectively. All operating lease expense is recognized on a straight-line basis over the lease term. In the
three
months ended
March 
31,
2019,
the Company recorded
$2.8
million of operating lease amortization that was charged to expense, and
$1.8
million of operating lease amortization for certain contract manufacturing arrangements that was capitalized to inventory.
 
Because the rate implicit in each lease is
not
readily determinable, the Company uses its incremental borrowing rate to determine the present value of the lease payments. The Company has certain contracts for real estate and marketing which
may
contain lease and non-lease components which it has elected to treat as a single lease component.
 
Information related to the Company's right-of-use assets and related lease liabilities were as follows:
 
Amounts in thousands
  Three Months Ended March 31, 2019
Cash paid for operating lease liabilities   $
5,305
 
Right-of-use assets obtained in exchange for new operating lease obligations
(1)
  $
30,472
 
Weighted-average remaining lease term (in years)    
2.7
 
Weighted-average discount rate    
18.0
%
 
(
1
) Includes 
$29.7
million for operating leases existing on
January 1, 2019
and 
$0.8
million for operating leases that commenced in the
first
quarter of
2019.
 
Financing Leases
 
The Company has entered into financing leases primarily for laboratory and computer equipment. Assets purchased under financing leases are included in "Property, plant and equipment, net" on the condensed consolidated balance sheets. For financing leases, the associated assets are depreciated or amortized over the shorter of the relevant useful life of each asset or the lease term. Property, plant and equipment, net included
$5.3
million and
$5.0
million of machinery and equipment under financing leases as of
March 
31,
2019
and
December 
31,
2018,
respectively. Accumulated amortization of assets under financing leases totaled
$2.5
million and
$2.3
million as of
March 
31,
2019
and
December 
31,
2018,
respectively.
 
Maturities of Financing and Operating Leases
 
Maturities of lease liabilities as of
March 
31,
2019
were as follows:
 
Years ending December 31:

(In thousands)
  Financing Leases   Operating
Leases
  Total Leases
2019 (remaining nine months)   $
368
    $
12,755
    $
13,123
 
2020    
199
     
9,109
     
9,308
 
2021    
1
     
7,226
     
7,227
 
2022    
     
7,398
     
7,398
 
2023    
     
3,034
     
3,034
 
Thereafter    
     
     
 
Total lease payments    
568
     
39,522
     
40,090
 
Less: amount representing interest
   
(23
)    
(9,793
)    
(9,816
)
Total lease liability   $
545
    $
29,729
    $
30,274
 
                         
Current lease liability   $
452
    $
10,972
    $
11,424
 
Noncurrent lease liability    
93
     
18,757
     
18,850
 
Total lease liability   $
545
    $
29,729
    $
30,274
 
 
Other Assets
 
(In thousands)
  March 31, 2019   December 31, 2018
Contingent consideration   $
4,286
    $
4,286
 
Deposits    
145
     
2,465
 
Other    
1,117
     
1,207
 
Other assets   $
5,548
    $
7,958
 
 
Accrued and Other Current Liabilities
 
(In thousands)
  March 31, 2019   December 31, 2018
DSM manufacturing capacity fee   $
7,250
    $
 
Contract termination fees  
5,337
   
6,247
 
Accrued interest    
7,094
     
3,853
 
Payroll and related expenses    
5,285
     
9,220
 
Asset retirement obligation    
3,111
     
3,063
 
Tax-related liabilities    
2,589
     
2,139
 
Professional services    
1,871
     
1,173
 
Other    
1,054
     
3,284
 
Total accrued and other current liabilities   $
33,591
    $
28,979
 
 
Other noncurrent liabilities
 
(In thousands)
  March 31, 2019   December 31, 2018
Contract termination fees, net of current portion   $
8,207
    $
7,715
 
Liability for unrecognized tax benefit    
6,582
     
6,582
 
Contract liability, net of current portion (Note 9)    
1,449
     
1,587
 
Deferred rent, net of current portion
(1)
   
     
6,440
 
Other    
682
     
868
 
Total other noncurrent liabilities   $
16,920
    $
23,192
 
 
(
1
)    
Deferred rent at
December 31, 2018
was reclassified to ROU asset upon the adoption on
January 1, 2019
of ASC
842,
"Leases".
XML 15 R14.htm IDEA: XBRL DOCUMENT v3.19.3
Note 6 - Stockholders' Deficit
3 Months Ended
Mar. 31, 2019
Notes to Financial Statements  
Stockholders' Equity Note Disclosure [Text Block]
6.
Stockholders' Deficit
 
Warrants
 
In connection with various debt and equity transactions (see Note
5,
"Debt" and Note
7,
“Stockholders’ Deficit” in Part II, Item
8
of the
2018
Form
10
-K/A), the Company has issued warrants exercisable for shares of common stock. The following table summarizes warrant activity for the
three
months ended
March 
31,
2019:
 
Transaction   Number Outstanding as of December 31, 2018   Additional Warrants Issued   Exercises   Number Outstanding as of March 31, 2019
August 2018 warrant exercise agreements    
12,097,164
     
     
     
12,097,164
 
May 2017 cash and dilution warrants    
6,292,798
     
     
     
6,292,798
 
August 2017 cash and dilution warrants    
3,968,116
     
     
     
3,968,116
 
April 2018 warrant exercise agreements    
3,616,174
     
     
     
3,616,174
 
July 2015 related party debt exchange    
663,228
     
     
(471,204
)    
192,024
 
February 2016 related party private placement    
171,429
     
     
     
171,429
 
July 2015 private placement    
81,197
     
     
(8,547
)    
72,650
 
Other    
1,406
     
     
     
1,406
 
     
26,891,512
     
     
(479,751
)    
26,411,761
 
 
For the
three
months ended
March 
31,
2019,
479,751
shares of common stock were issued under certain anti-dilution warrants with an exercise price of
$0.01
and resulted in
no
proceeds to the Company. The shares were exercised through net share settlement, resulting in the issuance of
450,568
shares.
XML 16 R3.htm IDEA: XBRL DOCUMENT v3.19.3
Condensed Consolidated Balance Sheets (Current Period Unaudited) (Parentheticals) - USD ($)
$ in Thousands
Mar. 31, 2019
Dec. 31, 2018
Accounts receivable, allowance $ 126 $ 642
Accounts receivable, related party, allowance 12 0
Debt, current portion, fair value $ 60,048 $ 57,918
Preferred stock, par value (in dollars per share) $ 0.0001 $ 0.0001
Preferred stock, shares authorized (in shares) 5,000,000 5,000,000
Preferred stock, shares issued (in shares) 14,656 14,656
Preferred stock, shares outstanding (in shares) 14,656 14,656
Common stock, par value (in dollars per share) $ 0.0001 $ 0.0001
Common stock, shares authorized (in shares) 250,000,000 250,000,000
Common stock, shares issued (in shares) 77,210,681 76,564,829
Common stock, shares outstanding (in shares) 77,210,681 76,564,829
XML 17 R37.htm IDEA: XBRL DOCUMENT v3.19.3
Note 2 - Balance Sheet Details - Right-of-use Assets and Related Lease Liabilities (Details)
$ in Thousands
3 Months Ended
Mar. 31, 2019
USD ($)
Cash paid for operating lease liabilities $ 5,305
Right-of-use assets obtained in exchange for new operating lease obligations(1) $ 30,472 [1]
Weighted-average remaining lease term (in years) (Year) 2 years 255 days
Weighted-average discount rate 18.00%
[1] Includes $26.7 million for operating leases existing on January 1, 2019 and $0.9 million for operating leases that commenced in the first quarter of 2019.
XML 18 R33.htm IDEA: XBRL DOCUMENT v3.19.3
Note 2 - Balance Sheet Details - Inventory, Current (Details) - USD ($)
$ in Thousands
Mar. 31, 2019
Dec. 31, 2018
Raw materials $ 2,451 $ 3,901
Work-in-process 238 539
Finished goods 5,797 5,253
Inventories $ 8,486 $ 9,693
XML 19 R52.htm IDEA: XBRL DOCUMENT v3.19.3
Note 6 - Stockholders' Deficit - Warrant Activity (Details)
3 Months Ended
Mar. 31, 2019
shares
Number outstanding, beginning balance (in shares) 26,891,512
Additional Warrants Issued (in shares)
Exercises (in shares) (479,751)
Number outstanding, ending balance (in shares) 26,411,761
Warrant 6 [Member]  
Number outstanding, beginning balance (in shares) 12,097,164
Additional Warrants Issued (in shares)
Exercises (in shares)
Number outstanding, ending balance (in shares) 12,097,164
Warrant 4 [Member]  
Number outstanding, beginning balance (in shares) 6,292,798
Additional Warrants Issued (in shares)
Exercises (in shares)
Number outstanding, ending balance (in shares) 6,292,798
Warrant 5 [Member]  
Number outstanding, beginning balance (in shares) 3,968,116
Additional Warrants Issued (in shares)
Exercises (in shares)
Number outstanding, ending balance (in shares) 3,968,116
Warrant 7 [Member]  
Number outstanding, beginning balance (in shares) 3,616,174
Additional Warrants Issued (in shares)
Exercises (in shares)
Number outstanding, ending balance (in shares) 3,616,174
Warrant 2 [Member]  
Number outstanding, beginning balance (in shares) 663,228
Additional Warrants Issued (in shares)
Exercises (in shares) (471,204)
Number outstanding, ending balance (in shares) 192,024
Warrant 3 [Member]  
Number outstanding, beginning balance (in shares) 171,429
Additional Warrants Issued (in shares)
Exercises (in shares)
Number outstanding, ending balance (in shares) 171,429
Warrant 1 [Member]  
Number outstanding, beginning balance (in shares) 81,197
Additional Warrants Issued (in shares)
Exercises (in shares) (8,547)
Number outstanding, ending balance (in shares) 72,650
Warrant 8 [Member]  
Number outstanding, beginning balance (in shares) 1,406
Additional Warrants Issued (in shares)
Exercises (in shares)
Number outstanding, ending balance (in shares) 1,406
XML 20 R56.htm IDEA: XBRL DOCUMENT v3.19.3
Note 9 - Revenue Recognition and Contract Assets and Liabilities 2 (Details Textual)
Mar. 31, 2019
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2019-04-01  
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period 273 days
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2020-01-01  
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period 1 year
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2021-01-01  
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period 1 year
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2022-01-01  
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period 1 year
XML 21 R47.htm IDEA: XBRL DOCUMENT v3.19.3
Note 4 - Debt - Debt Components (Details) - USD ($)
3 Months Ended 12 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Dec. 31, 2018
Principal $ 229,272,000   $ 228,921,000
Unamortized Debt Premium (13,493,000)   (17,142,000)
Loss from change in fair value of debt 48,000 (2,082,000)
Net Balance 215,827,000   209,697,000
Net Balance (153,752,000)   (147,677,000)
Net Balance 62,075,000   62,020,000
Convertible Senior Notes, 6.0% Due in 2021 [Member]      
Principal 60,000,000    
Convertible Debt [Member]      
Principal 126,754,000   126,306,000
Unamortized Debt Premium (1,243,000)   (3,350,000)
Loss from change in fair value of debt 48,000   (2,082,000)
Net Balance 125,559,000   120,874,000
Convertible Debt [Member] | Convertible Senior Notes, 6.0% Due in 2021 [Member]      
Principal 60,000,000   60,000,000
Unamortized Debt Premium  
Loss from change in fair value of debt 48,000   (2,082,000)
Net Balance 60,048,000   57,918,000
Convertible Debt [Member] | The 2015 144A Notes [Member]      
Principal 37,887,000   37,887,000
Unamortized Debt Premium (358,000)   (2,413,000)
Loss from change in fair value of debt  
Net Balance 37,529,000   35,474,000
Convertible Debt [Member] | The 2014 144A Notes [Member]      
Principal 24,004,000   24,004,000
Unamortized Debt Premium (289,000)   (867,000)
Loss from change in fair value of debt  
Net Balance 23,715,000   23,137,000
Convertible Debt [Member] | August 2013 Convertible Notes [Member]      
Principal 4,863,000   4,415,000
Unamortized Debt Premium (596,000)   (70,000)
Loss from change in fair value of debt  
Net Balance 4,267,000   4,345
Related Party Convertible Notes [Member] | The 2014 144A Notes [Member]      
Principal 24,705,000   24,705,000
Unamortized Debt Premium (346,000)   (1,038,000)
Loss from change in fair value of debt  
Net Balance 24,359,000   23,667,000
Nonrelated Party Debt [Member]      
Principal 36,000,000   36,000,000
Unamortized Debt Premium (1,208,000)   (1,349,000)
Loss from change in fair value of debt  
Net Balance 34,792,000   34,651,000
Loans Payable [Member]      
Principal 52,813,000   52,910,000
Unamortized Debt Premium (6,051,000)   (6,443,000)
Loss from change in fair value of debt  
Net Balance 46,762,000   46,467,000
Loans Payable [Member] | Ginkgo Collaboration Note [Member]      
Principal 12,000,000   12,000,000
Unamortized Debt Premium (3,832,000)   (4,047,000)
Loss from change in fair value of debt  
Net Balance 8,168,000   7,953,000
Loans Payable [Member] | Other Loans Payable [Member]      
Principal 4,813,000   4,910,000
Unamortized Debt Premium (1,011,000)   (1,047,000)
Loss from change in fair value of debt  
Net Balance 3,802,000   3,863,000
Related Party Loan Payable [Member] | DSM Note [Member]      
Principal 25,000,000   25,000,000
Unamortized Debt Premium (5,853,000)   (6,311,000)
Loss from change in fair value of debt  
Net Balance $ 19,147,000   $ 18,689,000
XML 22 R43.htm IDEA: XBRL DOCUMENT v3.19.3
Note 3 - Fair Value Measurement - Fair Value, Assets, and Liabilities Measured on Recurring Basis (Details) - USD ($)
$ in Thousands
Mar. 31, 2019
Dec. 31, 2018
Debt, current portion, fair value $ 60,048 $ 57,918
Fair Value, Recurring [Member]    
Debt, current portion, fair value 60,048 57,918
Freestanding derivative instruments in connection with the issuance of equity instruments 3,798 42,796
Total liabilities measured and recorded at fair value 63,846 100,714
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member]    
Debt, current portion, fair value
Freestanding derivative instruments in connection with the issuance of equity instruments
Total liabilities measured and recorded at fair value
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member]    
Debt, current portion, fair value
Freestanding derivative instruments in connection with the issuance of equity instruments
Total liabilities measured and recorded at fair value
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member]    
Debt, current portion, fair value 60,048 57,918
Freestanding derivative instruments in connection with the issuance of equity instruments 3,798 42,796
Total liabilities measured and recorded at fair value $ 63,846 $ 100,714
XML 23 R68.htm IDEA: XBRL DOCUMENT v3.19.3
Note 12 - Subsequent Events (Details Textual)
9 Months Ended
Sep. 23, 2019
USD ($)
Sep. 10, 2019
USD ($)
$ / shares
shares
Aug. 19, 2019
Aug. 14, 2019
USD ($)
$ / shares
shares
Aug. 08, 2019
USD ($)
Jul. 30, 2019
USD ($)
Jul. 26, 2019
USD ($)
Jul. 24, 2019
USD ($)
$ / shares
shares
Jul. 08, 2019
shares
Jun. 24, 2019
USD ($)
shares
May 15, 2019
USD ($)
$ / shares
shares
May 14, 2019
USD ($)
$ / shares
shares
May 10, 2019
USD ($)
$ / shares
shares
May 10, 2019
BRL (R$)
shares
May 03, 2019
USD ($)
$ / shares
shares
May 02, 2019
USD ($)
Apr. 29, 2019
USD ($)
$ / shares
shares
Apr. 26, 2019
USD ($)
$ / shares
shares
Apr. 16, 2019
USD ($)
$ / shares
shares
Apr. 15, 2019
USD ($)
Apr. 04, 2019
USD ($)
Jun. 30, 2020
USD ($)
Oct. 01, 2019
Sep. 30, 2019
Sep. 29, 2019
USD ($)
Sep. 19, 2019
USD ($)
Sep. 17, 2019
USD ($)
Sep. 16, 2019
USD ($)
Aug. 29, 2019
USD ($)
$ / shares
Aug. 28, 2019
$ / shares
Aug. 01, 2019
USD ($)
Jul. 29, 2019
USD ($)
Jul. 18, 2019
Jul. 10, 2019
USD ($)
$ / shares
Jun. 11, 2019
USD ($)
Apr. 08, 2019
USD ($)
Mar. 31, 2019
USD ($)
Dec. 31, 2018
USD ($)
Dec. 10, 2018
USD ($)
Aug. 17, 2018
$ / shares
Long-term Debt, Gross                                                                         $ 229,272,000 $ 228,921,000    
Long-term Debt, Total                                                                         215,827,000 209,697,000    
July Foris Credit Agreement [Member]                                                                                
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                                                                               $ 7.52
Convertible Debt [Member]                                                                                
Long-term Debt, Gross                                                                         126,754,000 126,306,000    
Long-term Debt, Total                                                                         125,559,000 $ 120,874,000    
Convertible Senior Notes, 6.0% Due in 2021 [Member]                                                                                
Debt Instrument, Interest Rate, Stated Percentage                                                                           6.00% 6.00%  
Debt Instrument, Face Amount                                                                             $ 60,000,000  
Long-term Debt, Gross                                                                         60,000,000      
Convertible Senior Notes, 6.0% Due in 2021 [Member] | Convertible Debt [Member]                                                                                
Long-term Debt, Gross                                                                         60,000,000 $ 60,000,000    
Long-term Debt, Total                                                                         60,048,000 57,918,000    
August 2013 Convertible Notes [Member] | Convertible Debt [Member]                                                                                
Long-term Debt, Gross                                                                         4,863,000 4,415,000    
Long-term Debt, Total                                                                         $ 4,267,000 $ 4,345    
DSM International B.V. [Member] | The 2019 DSM Credit Agreement [Member] | Forecast [Member]                                                                                
Proceeds from Sale of Equity Securities, Gross, Trigger Repayment of Amounts Outstanding Under Line of Credit                                           $ 50,000,000                                    
Subsequent Event [Member] | Private Placement [Member]                                                                                
Warrant Exercise, Beneficial Common Stock Ownership Maximum Percentage                             19.99%                                                  
Proceeds from Issuance of Common Stock                             $ 5,000,000   $ 5,800,000 $ 23,200,000                                            
Subsequent Event [Member] | LSA Amendment Warrants [Member]                                                                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares       1,438,829                                                                        
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares       $ 2.87                                                                        
Warrants and Rights Outstanding, Term       2 years                                                                        
Warrant Exercise, Beneficial Common Stock Ownership Maximum Percentage       19.99%                                                                        
Subsequent Event [Member] | July Foris Credit Agreement [Member]                                                                                
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                                                                   $ 2.87            
Subsequent Event [Member] | Warrants Issued for 2014 Rule 144A Convertible Notes Exchanges [Member]                                                                                
Class of Warrant or Right, Stock Ownership Percentage, Restriction on Ability to Exercise                     4.99%                                                          
Subsequent Event [Member] | August Foris Credit Agreement [Member]                                                                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares       4,871,795                                                                        
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares       $ 3.90                                                                        
Class of Warrant or Right, Term       2 years                                                                        
Class of Warrant or Right, Stock Ownership Percentage, Restriction on Ability to Exercise       19.99%                                                                        
Subsequent Event [Member] | Warrants Issued in Exchange for 6% Convertible Notes Due 2021 [Member]                                                                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares               2,000,000   181,818 2,000,000                                                          
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                     $ 5.12                                                          
Debt Instrument, Repayment Price, Percent of Face Amount                     4.99%                                                          
Class of Warrant or Right, Term                   2 years                                                            
Subsequent Event [Member] | Warrants Issued in Exchange for Convertible Senior Notes, 6.0% Due 2021, Second Exchange [Member]                                                                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares               2,000,000                                                                
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares               $ 2.87                                                                
Class of Warrant or Right, Term                     2 years                                                          
Subsequent Event [Member] | Warrants Issued in Exchange for August 2013 Financing Convertible Note [Member]                                                                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares                 1,080,000                                                              
Class of Warrant or Right, Stock Ownership Percentage, Restriction on Ability to Exercise                 4.99%                                                              
Subsequent Event [Member] | Investor Warrants [Member]                                                                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares   3,205,128                                                                            
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares   $ 3.90                                                                            
Warrants and Rights Outstanding, Term   2 years                                                                            
Warrants or Rights Outstanding, Maximum Percent of Common Stock Outstanding   9.99%                                                                            
Warrants or Rights Outstanding, Reduction in Exercise Price   10.00%                                                                            
Warrants or Rights Outstanding, Additional Reduction in Exercise Price   5.00%                                                                            
Subsequent Event [Member] | Minimum [Member] | Investor Warrants [Member]                                                                                
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares   $ 3.31                                                                            
Subsequent Event [Member] | Foris Ventures, LLC [Member]                                                                                
Related Party Transaction, Purchases from Related Party                                       $ 2,500,000                                        
Subsequent Event [Member] | Raizen Energia S.A. [Member]                                                                                
Capital Contribution to the Joint Venture | R$                           R$ 2,500,000                                                    
Equity Method Investment, Ownership Percentage                         50.00%                                                      
Equity Method Investment, Ownership Percentage by Counterparty                         50.00%                                                      
Subsequent Event [Member] | Raizen Energia S.A. [Member] | Fixed Assets Owned by the Company [Member]                                                                                
Payments to Acquire Property, Plant, and Equipment, Total                         $ 9,000,000                                                      
Subsequent Event [Member] | Raizen Energia S.A. [Member] | Fixed Assets From Sao Martinho S.A. [Member]                                                                                
Payments to Acquire Property, Plant, and Equipment, Total                         $ 3,000,000                                                      
Subsequent Event [Member] | Loan and Security Agreement Amendment and Waiver [Member]                                                                                
Debt Instrument, Interest Rate, Stated Percentage     4.75%                                                                          
Long-term Debt, Gross       $ 71,000,000                                                                        
Subsequent Event [Member] | Loan and Security Agreement Amendment and Waiver [Member] | Unsecured Promissory Note [Member]                                                                                
Debt Instrument, Face Amount       $ 32,500,000                                                                        
Subsequent Event [Member] | Loan and Security Agreement Amendment and Waiver [Member] | Base Rate [Member] | Minimum [Member]                                                                                
Debt Instrument, Basis Spread on Variable Rate     9.00%                                                                          
Subsequent Event [Member] | Loan and Security Agreement Amendment and Waiver [Member] | Base Rate [Member] | Maximum [Member]                                                                                
Debt Instrument, Basis Spread on Variable Rate     12.00%                                                                          
Subsequent Event [Member] | Convertible Senior Notes, 6.0% Due in 2021 [Member]                                                                                
Debt Instrument, Face Amount                     $ 68,300,000                                                          
Debt Instrument, Repayment Price, Percent of Face Amount             125.00%       125.00%                                                          
Debt Conversion, Original Debt, Amount             $ 4,700,000 $ 53,300,000   $ 4,700,000 $ 53,300,000                                                          
Debt Instrument, Penalty for Failure to Make Payment, Premium Increase Percentage                     25.00%                                                          
Debt Instrument, Periodic Payment, Principal                     $ 6,400,000                                                          
Subsequent Event [Member] | Convertible Senior Notes, 6.0%, Due in 2021, Second Exchange [Member]                                                                                
Debt Instrument, Interest Rate, Stated Percentage               18.00%                                                                
Debt Instrument, Face Amount               $ 68,300,000                                                                
Debt Instrument, Periodic Payment, Principal               $ 3,200,000                                                                
Debt Instrument, Debt Default, Amount                                                       $ 63,600,000                        
Subsequent Event [Member] | August 2013 Convertible Notes [Member] | Convertible Debt [Member]                                                                                
Debt Conversion, Converted Instrument, Shares Issued | shares                 1,767,632                                                              
Subsequent Event [Member] | Nikko Loan Agreement [Member]                                                                                
Debt Instrument, Interest Rate, Stated Percentage                                                               5.00%                
Long-term Debt, Total                                                               $ 5,000,000                
Subsequent Event [Member] | Nikko Loan Agreement, First Installment [Member]                                                                                
Debt Instrument, Face Amount           $ 3,000,000                                                                    
Proceeds from Issuance of Long-term Debt, Total           2,800,000                                                                    
Subsequent Event [Member] | Nikko Loan Agreement, Second Installment [Member]                                                                                
Debt Instrument, Face Amount         $ 2,000,000                                                                      
Proceeds from Issuance of Long-term Debt, Total         1,900,000                                                                      
Subsequent Event [Member] | Second Aprinnova Note [Member]                                                                                
Debt Instrument, Interest Rate, Stated Percentage                                                             10.00%                  
Debt Instrument, Face Amount                                                             $ 2,018,000,000                  
Subsequent Event [Member] | The Naxyris Loan Agreement [Member]                                                                                
Debt Instrument, Interest Rate, Stated Percentage       12.00%                                                                        
Debt Instrument, Face Amount       $ 10,435,000                                                                        
Debt Instrument, Failure to Pay Fee       6.00%                                                                        
Subsequent Event [Member] | The Naxyris Loan Agreement [Member] | Interest Wtih Respect to Indebtedness [Member]                                                                                
Debt Instrument, Basis Spread on Variable Rate       0.25%                                                                        
Subsequent Event [Member] | The Investor Notes [Member]                                                                                
Debt Instrument, Interest Rate, Stated Percentage   12.00%                                                                            
Debt Instrument, Face Amount   $ 12,500,000                                                                            
Debt Instrument, Early Repayment Amount, Percentage   100.00%                                                                            
Subsequent Event [Member] | Secured Promissory Note In Connection With Termination of Ginkgo Collaboration Agreement [Member]                                                                                
Debt Instrument, Interest Rate, Stated Percentage                                             12.00%   10.50%                              
Debt Instrument, Cash Waiver Fee Amount Payable                                                 $ 1,300,000                              
Subsequent Event [Member] | Great American Capital Partners, LLC [Member] | Loan and Security Agreement [Member]                                                                                
Debt Instrument, Requirement, Unrestricted, Unencumbered Cash                                         $ 15,000,000                                      
Payments for debt agreement amendment                                         $ 800,000                                      
Subsequent Event [Member] | Foris Ventures, LLC [Member] | April Foris Credit Agreement [Member]                                                                                
Debt Instrument, Interest Rate, Stated Percentage                                                                       0.00%        
Debt Instrument, Face Amount                                                                       $ 8,000,000        
Line of Credit Facility, Maximum Borrowing Capacity                                                                       8,000,000        
Subsequent Event [Member] | Foris Ventures, LLC [Member] | April Foris Credit Agreement [Member] | Minimum [Member]                                                                                
Debt Instrument, Fee Amount                                                                       1,000,000        
Subsequent Event [Member] | Foris Ventures, LLC [Member] | April Foris Credit Agreement [Member] | Maximum [Member]                                                                                
Debt Instrument, Fee Amount                                                                       $ 500,000        
Subsequent Event [Member] | Foris Ventures, LLC [Member] | June Foris Credit Agreement [Member]                                                                                
Debt Instrument, Interest Rate, Stated Percentage                                                                     12.50%          
Debt Instrument, Face Amount                                                                     $ 8,500,000          
Line of Credit Facility, Maximum Borrowing Capacity                                                                     $ 8,500,000          
Subsequent Event [Member] | Foris Ventures, LLC [Member] | July Foris Credit Agreement [Member]                                                                                
Debt Instrument, Interest Rate, Stated Percentage                                                                   12.50%            
Debt Instrument, Face Amount                                                                   $ 8,000,000            
Line of Credit Facility, Maximum Borrowing Capacity                                                                   16,000,000            
Long-term Line of Credit, Total             $ 8,000,000                                                     $ 8,000,000            
Subsequent Event [Member] | Foris Ventures, LLC [Member] | Foris Credit Agreements [Member]                                                                                
Debt Instrument, Repayment Price, Percent of Face Amount                                               100.00%                                
Subsequent Event [Member] | Foris Ventures, LLC [Member] | August Foris Credit Agreement [Member]                                                                                
Debt Instrument, Interest Rate, Stated Percentage                                                         12.00%                      
Debt Instrument, Face Amount                                                         $ 19,000,000                      
Line of Credit Facility, Maximum Borrowing Capacity                                                         $ 19,000,000                      
Debt Instrument, Repayment Price, Percent of Face Amount                                               100.00%                                
Subsequent Event [Member] | DSM International B.V. [Member] | The 2019 DSM Credit Agreement [Member]                                                                                
Debt Instrument, Interest Rate, Stated Percentage                                                     12.50%                          
Line of Credit Facility, Maximum Borrowing Capacity                                                     $ 8,000,000                          
Subsequent Event [Member] | DSM International B.V. [Member] | The 2019 DSM Credit Agreement, Second Installment [Member]                                                                                
Debt Instrument, Face Amount                                                   $ 3,000,000                            
Line of Credit Facility, Incremental Draw Down Amount                                                   $ 3,000,000 3,000,000                          
Subsequent Event [Member] | DSM International B.V. [Member] | The 2019 DSM Credit Agreement, Third Installment [Member]                                                                                
Debt Instrument, Face Amount $ 2,000,000                                                                              
Extinguishment of Debt, Amount 1,500,000                                                                              
Line of Credit Facility, Incremental Draw Down Amount $ 2,000,000                                                   2,000,000                          
Subsequent Event [Member] | DSM International B.V. [Member] | The 2019 DSM Credit Agreement, First Installment [Member]                                                                                
Debt Instrument, Face Amount                                                     3,000,000                          
Line of Credit Facility, Incremental Draw Down Amount                                                     $ 3,000,000                          
Subsequent Event [Member] | The Investors [Member]                                                                                
Line of Credit Facility, Maximum Borrowing Capacity   $ 12,500,000                                                                            
Subsequent Event [Member] | Foris Ventures, LLC [Member] | Private Placement [Member]                                                                                
Stock Issued During Period, Shares, New Issues | shares                                   2,832,440 6,732,369                                          
Shares Issued, Price Per Share | $ / shares                                   $ 5.12 $ 2.87                                          
Proceeds from Issuance of Common Stock                                     $ 20,000,000                                          
Subsequent Event [Member] | Foris Ventures, LLC [Member] | Private Placement, April 26, 2019 [Member]                                                                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares                                   3,983,230                                            
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                                   $ 5.12                     $ 3.90 $ 3.90                    
Class of Warrant or Right, Term                                   2 years                                            
Subsequent Event [Member] | Foris Ventures, LLC [Member] | Warrants Issued for 2014 Rule 144A Convertible Notes Exchanges [Member]                                                                                
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                       $ 4.56                                   $ 3.90                    
Class of Warrant or Right, Term                       2 years                                                        
Debt Conversion, Converted Instrument, Warrants Issued | shares                       352,638                                                        
Subsequent Event [Member] | Foris Ventures, LLC [Member] | Private Placement, April 16, 2019 [Member]                                                                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares                                     5,424,804                                          
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                                     $ 2.87                                          
Class of Warrant or Right, Term                                     2 years                                          
Subsequent Event [Member] | Foris Ventures, LLC [Member] | Rule 144A Convertible Notes [Member]                                                                                
Debt Conversion, Original Debt, Amount                       $ 5,000,000                                                        
Debt Conversion, Converted Instrument, Shares Issued | shares                       1,122,460                                                        
Subsequent Event [Member] | Other Non-affiliated Investors [Member] | Private Placement [Member]                                                                                
Stock Issued During Period, Shares, New Issues | shares                             1,243,781   323,382 2,043,781                                            
Shares Issued, Price Per Share | $ / shares                             $ 4.02   $ 4.02 $ 4.02                                            
Subsequent Event [Member] | Other Non-affiliated Investors [Member] | Private Placement, April 26, 2019 [Member]                                                                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares                                   1,635,025                                            
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                                   $ 5.02                                            
Warrants and Rights Outstanding, Term                                   2 years                                            
Subsequent Event [Member] | Other Non-affiliated Investors [Member] | Warrants Issued for 2014 Rule 144A Convertible Notes Exchanges [Member]                                                                                
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                         $ 5.02                                                      
Class of Warrant or Right, Term                         2 years 2 years                                                    
Debt Conversion, Converted Instrument, Warrants Issued | shares                         1,391,603 1,391,603                                                    
Subsequent Event [Member] | Other Non-affiliated Investors [Member] | Private Placement April 29, 2019 [Member]                                                                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares                                 258,704                                              
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                                 $ 5.02                                              
Warrants and Rights Outstanding, Term                                 2 years                                              
Subsequent Event [Member] | Other Non-affiliated Investors [Member] | Private Placement May 3, 2019 [Member]                                                                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares                             995,024                                                  
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                             $ 5.02                                                  
Warrants and Rights Outstanding, Term                             2 years                                                  
Subsequent Event [Member] | Other Non-affiliated Investors [Member] | Rule 144A Convertible Notes [Member]                                                                                
Repayments of Debt                                     $ 37,900,000                                          
Debt Conversion, Original Debt, Amount                         $ 13,500,000                                                      
Debt Conversion, Converted Instrument, Shares Issued | shares                         3,479,008 3,479,008                                                    
Subsequent Event [Member] | Vivo Capital LLC [Member] | Private Placement [Member]                                                                                
Stock Issued During Period, Shares, New Issues | shares                                 913,529                                              
Shares Issued, Price Per Share | $ / shares                                 $ 4.76                                              
Subsequent Event [Member] | Vivo Capital LLC [Member] | Private Placement April 29, 2019 [Member]                                                                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares                                 1,212,787                                              
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                                 $ 4.76                                              
Warrants and Rights Outstanding, Term                                 2 years                                              
Subsequent Event [Member] | DSM International B.V. [Member]                                                                                
Consideration Transferred                                     57,000,000                                          
Consideration Transferred, Cash Amount                                     29,100,000                                          
Extinguishment of Debt, Amount                                     $ 27,900,000                                          
Subsequent Event [Member] | Maxwell (Mauritius) Pte Ltd [Member] | Rule 144A Convertible Notes [Member]                                                                                
Debt Conversion, Original Debt, Amount                     $ 10,000,000                                                          
Debt Conversion, Converted Instrument, Shares Issued | shares                     2,500,000                                                          
Subsequent Event [Member] | Total [Member] | Rule 144A Convertible Notes [Member]                                                                                
Debt Instrument, Interest Rate, Stated Percentage                                                                 10.50%              
Debt Conversion, Original Debt, Amount                     $ 9,700,000                                                          
Subsequent Event [Member] | Nikko [Member] | Nikko Loan Agreement [Member] | Aprinnova JV [Member]                                                                                
First Priority Lien on Interests Owned by the Company                                                               12.80%                
Subsequent Event [Member] | Nikko [Member] | Nikko Loan Agreement, First Installment [Member]                                                                                
Proceeds from Issuance of Long-term Debt, Withheld as Prepayment of Interest Payable           $ 200,000                                                                    
Subsequent Event [Member] | Nikko [Member] | Nikko Loan Agreement, Second Installment [Member]                                                                                
Proceeds from Issuance of Long-term Debt, Withheld as Prepayment of Interest Payable         $ 100,000                                                                      
Subsequent Event [Member] | The Cannabinoid Agreement [Member] | Lavvan [Member]                                                                                
Agreement Amount                               $ 300,000,000                                                
Agreement, Amount of Research and Development Funding that Could Be Received                               $ 300,000,000                                                
Agreement, Profit Sharing to Be Received from the Counterparty, Period                               20 years                                                
XML 24 R60.htm IDEA: XBRL DOCUMENT v3.19.3
Note 9 - Revenue Recognition and Contract Assets and Liabilities - Remaining Performance Obligations (Details)
$ in Millions
Mar. 31, 2019
USD ($)
Revenue, Remaining Performance Obligation, Amount $ 93.6
XML 25 R64.htm IDEA: XBRL DOCUMENT v3.19.3
Note 11 - Stock-based Compensation (Details Textual) - USD ($)
$ in Millions
3 Months Ended
Mar. 31, 2019
Jan. 01, 2019
Dec. 31, 2018
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total $ 31.1    
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition 3 years    
Shares, Outstanding, Ending Balance     76,564,829
Equity Incentive Plan, 2010 [Member]      
Automatic Annual Increase in the Number of Shares Available for Grant and Issuance   3,828,241  
Automatic Annual Increase in Shares Available for Grant and Issuance, Percentage of Outstanding Stock   5.00%  
Automatic Annual Increase in the Number of Shares Reserved for Issuance   383,824  
Automatic Annual Increase in Shares Reserved for Issuance, Percentage of Outstanding Stock   0.5  
XML 26 R22.htm IDEA: XBRL DOCUMENT v3.19.3
Note 2 - Balance Sheet Details (Tables)
3 Months Ended
Mar. 31, 2019
Notes Tables  
Schedule of Inventory, Current [Table Text Block]
(In thousands)
  March 31, 2019   December 31, 2018
Raw materials   $
2,451
    $
3,901
 
Work-in-process    
238
     
539
 
Finished goods    
5,797
     
5,253
 
Inventories   $
8,486
    $
9,693
 
Deferred Cost of Products Sold Disclosure [Table Text Block]
(In thousands)
  March 31, 2019   December 31, 2018
Deferred cost of products sold - related party   $
1,489
    $
489
 
Deferred cost of products sold, noncurrent - related party    
9,001
     
2,828
 
Total   $
10,490
    $
3,317
 
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Table Text Block]
(In thousands)
  March 31, 2019   December 31, 2018
Prepayments, advances and deposits   $
3,310
    $
5,644
 
Recoverable taxes from Brazilian government entities    
956
     
631
 
Other    
3,949
     
4,291
 
Total prepaid expenses and other current assets   $
8,215
    $
10,566
 
Property, Plant and Equipment [Table Text Block]
(In thousands)
  March 31, 2019   December 31, 2018
Machinery and equipment   $
45,874
    $
43,713
 
Leasehold improvements    
39,951
     
39,922
 
Computers and software    
10,138
     
9,987
 
Furniture and office equipment, vehicles and land    
3,279
     
3,016
 
Construction in progress    
1,460
     
1,749
 
Total property, plant and equipment, gross    
100,702
     
98,387
 
Less: accumulated depreciation and amortization    
(79,144
)    
(78,631
)
Property, plant and equipment, net   $
21,558
    $
19,756
 
Lease, Cost [Table Text Block]
Amounts in thousands
  Three Months Ended March 31, 2019
Cash paid for operating lease liabilities   $
5,305
 
Right-of-use assets obtained in exchange for new operating lease obligations
(1)
  $
30,472
 
Weighted-average remaining lease term (in years)    
2.7
 
Weighted-average discount rate    
18.0
%
Lessee, Lease Liability, Maturity [Table Text Block]
Years ending December 31:

(In thousands)
  Financing Leases   Operating
Leases
  Total Leases
2019 (remaining nine months)   $
368
    $
12,755
    $
13,123
 
2020    
199
     
9,109
     
9,308
 
2021    
1
     
7,226
     
7,227
 
2022    
     
7,398
     
7,398
 
2023    
     
3,034
     
3,034
 
Thereafter    
     
     
 
Total lease payments    
568
     
39,522
     
40,090
 
Less: amount representing interest
   
(23
)    
(9,793
)    
(9,816
)
Total lease liability   $
545
    $
29,729
    $
30,274
 
                         
Current lease liability   $
452
    $
10,972
    $
11,424
 
Noncurrent lease liability    
93
     
18,757
     
18,850
 
Total lease liability   $
545
    $
29,729
    $
30,274
 
Schedule of Other Assets, Noncurrent [Table Text Block]
(In thousands)
  March 31, 2019   December 31, 2018
Contingent consideration   $
4,286
    $
4,286
 
Deposits    
145
     
2,465
 
Other    
1,117
     
1,207
 
Other assets   $
5,548
    $
7,958
 
Schedule of Accrued and Other Current Liabilities [Table Text Block]
(In thousands)
  March 31, 2019   December 31, 2018
DSM manufacturing capacity fee   $
7,250
    $
 
Contract termination fees  
5,337
   
6,247
 
Accrued interest    
7,094
     
3,853
 
Payroll and related expenses    
5,285
     
9,220
 
Asset retirement obligation    
3,111
     
3,063
 
Tax-related liabilities    
2,589
     
2,139
 
Professional services    
1,871
     
1,173
 
Other    
1,054
     
3,284
 
Total accrued and other current liabilities   $
33,591
    $
28,979
 
Other Noncurrent Liabilities [Table Text Block]
(In thousands)
  March 31, 2019   December 31, 2018
Contract termination fees, net of current portion   $
8,207
    $
7,715
 
Liability for unrecognized tax benefit    
6,582
     
6,582
 
Contract liability, net of current portion (Note 9)    
1,449
     
1,587
 
Deferred rent, net of current portion
(1)
   
     
6,440
 
Other    
682
     
868
 
Total other noncurrent liabilities   $
16,920
    $
23,192
 
XML 27 R26.htm IDEA: XBRL DOCUMENT v3.19.3
Note 6 - Stockholders' Deficit (Tables)
3 Months Ended
Mar. 31, 2019
Notes Tables  
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
Transaction   Number Outstanding as of December 31, 2018   Additional Warrants Issued   Exercises   Number Outstanding as of March 31, 2019
August 2018 warrant exercise agreements    
12,097,164
     
     
     
12,097,164
 
May 2017 cash and dilution warrants    
6,292,798
     
     
     
6,292,798
 
August 2017 cash and dilution warrants    
3,968,116
     
     
     
3,968,116
 
April 2018 warrant exercise agreements    
3,616,174
     
     
     
3,616,174
 
July 2015 related party debt exchange    
663,228
     
     
(471,204
)    
192,024
 
February 2016 related party private placement    
171,429
     
     
     
171,429
 
July 2015 private placement    
81,197
     
     
(8,547
)    
72,650
 
Other    
1,406
     
     
     
1,406
 
     
26,891,512
     
     
(479,751
)    
26,411,761
 
XML 28 R46.htm IDEA: XBRL DOCUMENT v3.19.3
Note 4 - Debt (Details Textual) - Second Tranche [Member] - Related Party Convertible Notes [Member] - USD ($)
$ in Millions
Jul. 15, 2019
Jan. 14, 2019
Debt Instrument, Cash Waiver Fee Amount Payable   $ 0.6
Subsequent Event [Member]    
Debt Instrument, Interest Rate, Stated Percentage 1.75%  
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Note 3 - Fair Value Measurement (Details Textual)
3 Months Ended
Mar. 31, 2019
USD ($)
Dec. 31, 2018
USD ($)
Dec. 10, 2018
USD ($)
Long-term Debt, Gross $ 229,272,000 $ 228,921,000  
Long-term Debt, Fair Value 60,048,000 $ 57,918,000  
Debt, Long-term and Short-term, Combined Amount, Total 155,800,000    
Debt Instrument, Fair Value Disclosure, Total 155,800,000    
Convertible Senior Notes, 6.0% Due in 2021 [Member]      
Debt Instrument, Face Amount     $ 60,000,000
Debt Instrument, Interest Rate, Stated Percentage   6.00% 6.00%
Long-term Debt, Gross 60,000,000    
Long-term Debt, Fair Value 60,000,000    
Fair Value Adjustment of Debt $ (2,100,000)    
Convertible Senior Notes, 6.0% Due in 2021 [Member] | Measurement Input, Discount Rate [Member]      
Long-term Debt, Measurement Input 0.238    
Convertible Senior Notes, 6.0% Due in 2021 [Member] | Measurement Input, Price Volatility [Member]      
Long-term Debt, Measurement Input 0.45    
Convertible Senior Notes, 6.0% Due in 2021 [Member] | Probability of Principal Repayment in Cash [Member]      
Long-term Debt, Measurement Input 0.5    
Convertible Senior Notes, 6.0% Due in 2021 [Member] | Probability of Principal Repayment in Stock [Member]      
Long-term Debt, Measurement Input 0.5    
Convertible Senior Notes, 6.0% Due in 2021 [Member] | Measurement Input, Probability of Change in Control [Member]      
Long-term Debt, Measurement Input 0.05    
XML 31 R61.htm IDEA: XBRL DOCUMENT v3.19.3
Note 9 - Revenue Recognition and Contract Assets and Liabilities - Remaining Performance Obligations 2 (Details)
$ in Thousands
Mar. 31, 2019
USD ($)
Revenue, Remaining Performance Obligation, Amount $ 93,600
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2019-04-01  
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period 273 days
Revenue, Remaining Performance Obligation, Amount $ 23,920
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2020-01-01  
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period 1 year
Revenue, Remaining Performance Obligation, Amount $ 38,508
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2021-01-01  
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period 1 year
Revenue, Remaining Performance Obligation, Amount $ 31,172
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2022-01-01  
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period 1 year
Revenue, Remaining Performance Obligation, Amount
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Disaggregation of Revenue (Details) Details 57 false false R58.htm 057 - Disclosure - Note 9 - Revenue Recognition and Contract Assets and Liabilities - Revenue in Connection With Significant Revenue Agreement (Details) Sheet http://amyris.com/20190331/role/statement-note-9-revenue-recognition-and-contract-assets-and-liabilities-revenue-in-connection-with-significant-revenue-agreement-details Note 9 - Revenue Recognition and Contract Assets and Liabilities - Revenue in Connection With Significant Revenue Agreement (Details) Details 58 false false R59.htm 058 - Disclosure - Note 9 - Revenue Recognition and Contract Assets and Liabilities - Contract Balances (Details) Sheet http://amyris.com/20190331/role/statement-note-9-revenue-recognition-and-contract-assets-and-liabilities-contract-balances-details Note 9 - Revenue Recognition and Contract Assets and Liabilities - Contract Balances (Details) Details 59 false false R60.htm 059 - Disclosure - Note 9 - Revenue Recognition and Contract Assets and Liabilities - 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Note 11 - Stock-based Compensation - Share-based Compensation, Stock Options and Stock Appreciation Rights Award Activity (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 12 Months Ended
Mar. 31, 2019
Dec. 31, 2018
Outstanding (in shares) 5,390,270  
Outstanding, weighted average exercise price (in dollars per share) $ 11.55  
Outstanding, weighted average remaining contractual life (Year) 8 years 109 days 8 years 182 days
Outstanding, aggregate intrinsic value $ 29
Granted (in shares) 104,452  
Granted, weighted average exercise price (in dollars per share) $ 4.73  
Exercised (in shares) (3,612)  
Exercised, weighted average exercise price (in dollars per share) $ 3.68  
Forfeited or expired (in shares) (63,726)  
Forfeited or expired, weighted average exercise price (in dollars per share) $ 14.27  
Outstanding (in shares) 5,427,384 5,390,270
Outstanding, weighted average exercise price (in dollars per share) $ 11.39 $ 11.55
Vested or expected to vest (in shares) 4,874,155  
Vested and expected to vest, weighted average exercise price (in dollars per share) $ 12.10  
Vested and expected to vest, weighted average remaining contractual life (Year) 8 years 109 days  
Vested and expected to vest, aggregate intrinsic value  
Exercisable (in shares) 977,466  
Exercisable, weighted average exercise price (in dollars per share) $ 39.20  
Exercisable, weighted average remaining contractual life (Year) 5 years 292 days  
Exercisable, aggregate intrinsic value  
XML 35 R23.htm IDEA: XBRL DOCUMENT v3.19.3
Note 3 - Fair Value Measurement (Tables)
3 Months Ended
Mar. 31, 2019
Notes Tables  
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
(In thousands)   March 31, 2019   December 31, 2018
    Level 1   Level 2   Level 3   Total   Level 1   Level 2   Level 3   Total
Liabilities                                
6% Convertible Notes Due 2021   $
    $
    $
60,048
    $
60,048
    $
    $
    $
57,918
    $
57,918
 
Freestanding derivative instruments in connection with the issuance of equity instruments    
     
     
3,798
     
3,798
     
     
     
42,796
     
42,796
 
Total liabilities measured and recorded at fair value   $
    $
    $
63,846
    $
63,846
    $
    $
    $
100,714
    $
100,714
 
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
In thousands    
Fair value at December 31, 2018   $
57,918
 
Change in fair value    
2,130
 
Fair value at March 31, 2019   $
60,048
 
Fair Value, Net Derivative Asset (Liability) Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
(In thousands)   Equity-related Derivative Liability   Debt-related Derivative Liability   Total Derivative Liability
Balance at December 31, 2018   $
41,272
    $
1,524
    $
42,796
 
Derecognition upon adoption of ASU 2017-11    
(39,513
)    
(1,524
)    
(41,037
)
Change in fair value of derivative liabilities    
2,039
     
     
2,039
 
Balance at March 31, 2019   $
3,798
    $
    $
3,798
 
XML 36 R27.htm IDEA: XBRL DOCUMENT v3.19.3
Note 7 - Loss Per Share (Tables)
3 Months Ended
Mar. 31, 2019
Notes Tables  
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
    Three Months Ended March 31,
(In thousands, except shares and per share amounts)
  2019   2018
Numerator:        
Net loss attributable to Amyris, Inc.   $
(66,243
)   $
(92,802
)
Less: losses allocated to participating securities    
2,430
     
7,504
 
Net loss attributable to Amyris, Inc. common stockholders   $
(63,813
)   $
(85,298
)
                 
Denominator:                
Weighted-average shares of common stock outstanding used in computing loss per share of common stock, basic and diluted    
77,512,059
     
51,200,922
 
Loss per share attributable to common stockholders, basic and diluted   $
(0.82
)   $
(1.67
)
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
    Three Months Ended March 31,
    2019   2018
Period-end stock options to purchase common stock    
5,427,384
     
1,365,447
 
Convertible promissory notes
(1)
   
12,699,607
     
8,347,364
 
Period-end common stock warrants    
26,411,761
     
29,759,452
 
Period-end restricted stock units    
5,493,579
     
706,697
 
Period-end preferred stock    
2,955,732
     
4,504,212
 
Total potentially dilutive securities excluded from computation of diluted loss per share    
52,988,063
     
44,683,172
 
XML 37 R6.htm IDEA: XBRL DOCUMENT v3.19.3
Condensed Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Comprehensive loss:    
Net loss attributable to Amyris, Inc. $ (66,243) $ (92,802)
Foreign currency translation adjustment 964 (137)
Comprehensive loss attributable to Amyris, Inc. $ (65,279) $ (92,939)
XML 38 R11.htm IDEA: XBRL DOCUMENT v3.19.3
Note 3 - Fair Value Measurement
3 Months Ended
Mar. 31, 2019
Notes to Financial Statements  
Financial Instruments Disclosure [Text Block]
3.
Fair Value Measurement
 
Assets and Liabilities Measured and Recorded at Fair Value on a Recurring Basis
 
The following tables summarize assets and liabilities measured at fair value, and the respective fair value by input classification level within the fair value hierarchy:
 
(In thousands)   March 31, 2019   December 31, 2018
    Level 1   Level 2   Level 3   Total   Level 1   Level 2   Level 3   Total
Liabilities                                
6% Convertible Notes Due 2021   $
    $
    $
60,048
    $
60,048
    $
    $
    $
57,918
    $
57,918
 
Freestanding derivative instruments in connection with the issuance of equity instruments    
     
     
3,798
     
3,798
     
     
     
42,796
     
42,796
 
Total liabilities measured and recorded at fair value   $
    $
    $
63,846
    $
63,846
    $
    $
    $
100,714
    $
100,714
 
 
There were
no
transfers between levels during the periods presented.
 
6%
Convertible Notes Due
2021
 
The Company issued
$60.0
million of
6%
Convertible Notes Due
2021
on
December 10, 2018
and elected the fair value option of accounting for this instrument. At
March 
31,
2019,
outstanding principal was
$60.0
million, and the fair value was
$60.0
million, which was measured using a binomial lattice model and assuming a
23.8%
discount yield,
45%
equity volatility,
50%
/
50%
probability of principal repayment in cash / stock, and
5%
probability of change in control. See Note
4,
“Debt” for further information related to this debt instrument. For the
three
months ended
March 
31,
2019,
the Company recorded a
$2.1
million loss from change in fair value of debt in connection with the
6%
Convertible Notes Due
2021,
as follows:
 
In thousands    
Fair value at December 31, 2018   $
57,918
 
Change in fair value    
2,130
 
Fair value at March 31, 2019   $
60,048
 
 
Derivative Liabilities Recognized in Connection with the Issuance of Debt and Equity Instruments
 
The following table provides a reconciliation of the beginning and ending balances for the Company's derivative liabilities recognized in connection with the issuance of debt and equity instruments, measured at fair value using significant unobservable inputs (Level
3
):
 
(In thousands)   Equity-related Derivative Liability   Debt-related Derivative Liability   Total Derivative Liability
Balance at December 31, 2018   $
41,272
    $
1,524
    $
42,796
 
Derecognition upon adoption of ASU 2017-11    
(39,513
)    
(1,524
)    
(41,037
)
Change in fair value of derivative liabilities    
2,039
     
     
2,039
 
Balance at March 31, 2019   $
3,798
    $
    $
3,798
 
 
As of
March 
31,
2019,
the remaining derivative liabilities are in connection with the
November 2018
Securities Purchase Agreement with DSM. See Note
10,
“Revenue Recognition” in Part II, Item
8
of the
2018
10
-K/A. This make-whole provision is effectively marked to market through the condensed consolidated statements of operations, based on the Company’s closing stock price at each reporting period until converted into common stock or cash settled. The fair value of these instruments is directly affected by the volatility of the Company’s stock price between each reporting period or conversion date, if settled during the reporting period.
 
Assets and Liabilities Recorded at Carrying Value
 
Financial Assets and Liabilities
 
The carrying amounts of certain financial instruments, such as cash equivalents, accounts receivable, accounts payable and accrued liabilities, approximate fair value due to their relatively short maturities and low market interest rates, if applicable. Loans payable, credit facilities and convertible notes are recorded at carrying value (except for the
6%
Convertible Notes Due
2021,
which are recorded at fair value), which is representative of fair value at the date of acquisition. For loans payable and credit facilities recorded at carrying value, the Company estimates fair value using observable market-based inputs (Level
2
); for convertible notes, the Company estimates fair value based on rates currently offered for instruments with similar maturities and terms (Level
3
). The carrying amount (the total amount of net debt presented on the balance sheet) of the Company's debt at
March 
31,
2019,
excluding the
6%
Convertible Notes that the Company records at fair value, was
$155.8
million. The fair value of such debt at
March 
31,
2019
was
$155.8
million, and was determined by (i) discounting expected cash flows using current market discount rates estimated for certain of the debt instruments and (ii) using
third
-party fair value estimates for the remaining debt instruments.
XML 39 R15.htm IDEA: XBRL DOCUMENT v3.19.3
Note 7 - Loss Per Share
3 Months Ended
Mar. 31, 2019
Notes to Financial Statements  
Earnings Per Share [Text Block]
7.
Loss Per Share
 
For the
three
months ended
March 
31,
2019
and
March 
31,
2018,
basic loss per share was the same as diluted loss per share, because the inclusion of all potentially dilutive securities outstanding was antidilutive.
 
The Company follows the
two
-class method when computing net loss per common share when shares are issued that meet the definition of participating securities. The
two
-class method requires income available to common stockholders for the period to be allocated between common stock and participating securities based upon their respective rights to receive dividends as if all income for the period had been distributed. The
two
-class method also requires losses for the period to be allocated between common stock and participating securities based on their respective rights if the participating security contractually participates in losses. The Company’s convertible preferred stock are participating securities as they contractually entitle the holders of such shares to participate in dividends and contractually require the holders of such shares to participate in the Company’s losses.
 
The following table presents the calculation of basic and diluted loss per share:
 
    Three Months Ended March 31,
(In thousands, except shares and per share amounts)
  2019   2018
Numerator:        
Net loss attributable to Amyris, Inc.   $
(66,243
)   $
(92,802
)
Less: losses allocated to participating securities    
2,430
     
7,504
 
Net loss attributable to Amyris, Inc. common stockholders   $
(63,813
)   $
(85,298
)
                 
Denominator:                
Weighted-average shares of common stock outstanding used in computing loss per share of common stock, basic and diluted    
77,512,059
     
51,200,922
 
Loss per share attributable to common stockholders, basic and diluted   $
(0.82
)   $
(1.67
)
 
The following outstanding shares of potentially dilutive securities were excluded from the computation of diluted loss per share of common stock because including them would have been antidilutive:
 
    Three Months Ended March 31,
    2019   2018
Period-end stock options to purchase common stock    
5,427,384
     
1,365,447
 
Convertible promissory notes
(1)
   
12,699,607
     
8,347,364
 
Period-end common stock warrants    
26,411,761
     
29,759,452
 
Period-end restricted stock units    
5,493,579
     
706,697
 
Period-end preferred stock    
2,955,732
     
4,504,212
 
Total potentially dilutive securities excluded from computation of diluted loss per share    
52,988,063
     
44,683,172
 
______________
(
1
)
The potentially dilutive effect of convertible promissory notes was computed based on conversion ratios in effect as of the respective period end dates. A portion of the convertible promissory notes issued carries a provision for a reduction in conversion price under certain circumstances, which could potentially increase the dilutive shares outstanding. Another portion of the convertible promissory notes issued carries a provision for an increase in the conversion rate under certain circumstances, which could also potentially increase the dilutive shares outstanding.
XML 40 R2.htm IDEA: XBRL DOCUMENT v3.19.3
Condensed Consolidated Balance Sheets (Current Period Unaudited) - USD ($)
$ in Thousands
Mar. 31, 2019
Dec. 31, 2018
Current assets:    
Cash and cash equivalents $ 5,153 $ 45,353
Restricted cash 623 741
Accounts receivable, net 10,968 16,003
Accounts receivable - related party, net 1,334 1,349
Accounts receivable, unbilled - related party 8,021
Inventories 8,486 9,693
Deferred cost of products sold - related party 1,489 489
Prepaid expenses and other current assets 8,215 10,566
Total current assets 36,268 92,215
Property, plant and equipment, net 21,558 19,756
Accounts receivable, unbilled, noncurrent - related party [1] 1,203 1,203
Deferred cost of products sold, noncurrent - related party 9,001 2,828
Restricted cash, noncurrent 960 960
Recoverable taxes from Brazilian government entities 2,964 3,005
Right-of-use assets under operating leases (Note 2) 27,645
Other assets 5,548 7,958
Total assets 105,147 127,925
Current liabilities:    
Accounts payable 28,604 26,844
Accrued and other current liabilities 33,591 28,979
Lease liabilities (Note 2) 11,424
Contract liabilities 8,333 8,236
Debt, current portion (instrument measured at fair value $60,048 and $57,918, respectively) 129,393 124,010
Related party debt, current portion 24,359 23,667
Total current liabilities 235,704 211,736
Long-term debt, net of current portion 42,928 43,331
Related party debt, net of current portion 19,147 18,689
Lease liabilities, net of current portion (Note 2) 18,850
Derivative liabilities 3,798 42,796
Other noncurrent liabilities 16,920 23,192
Total liabilities 337,347 339,744
Commitments and contingencies (Note 8)
Mezzanine Equity 5,000 5,000
Stockholders’ deficit:    
Preferred stock - $0.0001 par value, 5,000,000 shares authorized as of March 31, 2019 and December 31, 2018, and 14,656 shares issued and outstanding as of March 31, 2019 and December 31, 2018, respectively
Common stock - $0.0001 par value, 250,000,000 shares authorized as of March 31, 2019 and December 31, 2018; 77,210,681 and 76,564,829 shares issued and outstanding as of March 31, 2019 and December 31, 2018, respectively 8 8
Additional paid-in capital 1,383,363 1,346,996
Accumulated other comprehensive loss (42,379) (43,343)
Accumulated deficit (1,579,129) (1,521,417)
Total Amyris, Inc. stockholders’ deficit (238,137) (217,756)
Noncontrolling interest 937 937
Total stockholders' deficit (237,200) (216,819)
Total liabilities, mezzanine equity and stockholders' deficit $ 105,147 $ 127,925
[1] As of March 31, 2019 and December 31, 2018, contract liabilities, noncurrent is presented in Other Noncurrent Liabilities in the consolidated balance sheets because of its insignificance.
XML 41 R19.htm IDEA: XBRL DOCUMENT v3.19.3
Note 11 - Stock-based Compensation
3 Months Ended
Mar. 31, 2019
Notes to Financial Statements  
Share-based Payment Arrangement [Text Block]
11.
Stock-based Compensation
 
The Company’s stock option activity and related information for the
three
months ended
March 
31,
2019
was as follows:
 
    Quantity of Stock Options   Weighted-
average
Exercise
Price
  Weighted-average
Remaining
Contractual
Life, in Years
  Aggregate
Intrinsic
Value, in Thousands
Outstanding - December 31, 2018    
5,390,270
    $
11.55
     
8.5
    $
29
 
Granted    
104,452
    $
4.73
     
 
     
 
 
Exercised    
(3,612
)   $
3.68
     
 
     
 
 
Forfeited or expired    
(63,726
)   $
14.27
     
 
     
 
 
Outstanding - March 31, 2019    
5,427,384
    $
11.39
     
8.3
    $
 
Vested or expected to vest after March 31, 2019    
4,874,155
    $
12.10
     
8.3
    $
 
Exercisable at March 31, 2019    
977,466
    $
39.20
     
5.8
    $
 
 
The Company’s restricted stock units (RSUs) activity and related information for the
three
months ended
March 
31,
2019
was as follows:
 
    Quantity of Restricted Stock Units   Weighted-average Grant-date Fair Value   Weighted-average Remaining Contractual Life, in Years
Outstanding - December 31, 2018    
5,294,803
    $
5.50
     
1.7
 
Awarded    
493,790
    $
4.65
     
 
 
RSUs released    
(192,795
)   $
6.55
     
 
 
RSUs forfeited    
(102,219
)   $
5.61
     
 
 
Outstanding - March 31, 2019    
5,493,579
    $
5.38
     
1.5
 
Vested or expected to vest after March 31, 2019    
5,153,107
    $
5.39
     
1.5
 
 
Stock-based compensation expense related to employee and non-employee options, RSUs and ESPP during the
three
months ended
March 
31,
2019
and
2018
was allocated to research and development expense and sales, general and administrative expense as follows:
 
    Three Months Ended March 31,
(In thousands)   2019   2018
Research and development   $
663
    $
363
 
Sales, general and administrative    
2,789
     
915
 
Total stock-based compensation expense   $
3,452
    $
1,278
 
 
As of
March 
31,
2019,
there was unrecognized compensation expense of
$31.1
million related to stock options and RSUs. The Company expects to recognize this expense over a weighted-average period of
3.0
years.
 
Evergreen Shares for
2010
Equity Incentive Plan and
2010
Employee Stock Purchase Plan
 
In
February 2019,
the Company's Board of Directors (the Board) approved increases to the number of shares available for issuance under the Company's
2010
Equity Incentive Plan (the Equity Plan) and
2010
Employee Stock Purchase Plan (the Purchase Plan). These shares in connection with the Equity Plan represented an automatic annual increase in the number of shares available for grant and issuance under the Equity Plan of
3,828,241
shares. This increase is equal to approximately
5.0%
of the
76,564,829
total outstanding shares of the Company’s common stock as of
December 
31,
2018.
This automatic increase was effective as of
January 1, 2019.
These shares in connection with the Purchase Plan represented an automatic annual increase in the number of shares reserved for issuance under the Purchase Plan of
383,824
shares. This increase is equal to approximately
0.5%
of the
76,564,829
total outstanding shares of the Company’s common stock as of
December 
31,
2018.
This automatic increase was effective as of
January 1, 2019.
XML 42 R36.htm IDEA: XBRL DOCUMENT v3.19.3
Note 2 - Balance Sheet Details - Property, Plant and Equipment (Details) - USD ($)
$ in Thousands
Mar. 31, 2019
Dec. 31, 2018
Property, plant and equipment $ 100,702 $ 98,387
Less: accumulated depreciation and amortization (79,144) (78,631)
Property, plant and equipment, net 21,558 19,756
Machinery and Equipment [Member]    
Property, plant and equipment 45,874 43,713
Leasehold Improvements [Member]    
Property, plant and equipment 39,951 39,922
Computer Equipment and Software [Member]    
Property, plant and equipment 10,138 9,987
Furniture and Office Equipment, Vehicles and Land [Member]    
Property, plant and equipment 3,279 3,016
Construction in Progress [Member]    
Property, plant and equipment $ 1,460 $ 1,749
XML 43 R32.htm IDEA: XBRL DOCUMENT v3.19.3
Note 2 - Balance Sheet Details (Details Textual) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Jan. 01, 2019
Dec. 31, 2018
Manufacturing Capacity Reservation Fee Current $ 7,250    
Deferred Cost of Products Sold, Related Party 10,490     3,317
Capitalized Computer Software, Additions 200      
Operating Lease, Right-of-Use Asset 27,645   $ 800
Operating Lease, Liability, Total 29,729      
Operating Lease, Expense 2,800      
Finance Lease, Right-of-use Asset, Accumulated Amortization 2,500     2,300
Property, Plant and Equipment, Net [Member]        
Finance Lease, Right-of-Use Asset 5,300     5,000
Cost of Sales [Member]        
Operating Lease, Expense $ 1,800      
Accounting Standards Update 2016-02 [Member]        
Operating Lease, Right-of-Use Asset     29,700  
Operating Lease, Liability, Total     $ 33,600  
Minimum [Member]        
Lessee Operating Lease, Remaining Lease Term 1 year      
Lessee, Operating Lease, Renewal Term 1 year      
Maximum [Member]        
Lessee Operating Lease, Remaining Lease Term 5 years      
Lessee, Operating Lease, Renewal Term 5 years      
Machinery and Equipment, Furniture and Office Equipment Under Capital Lease [Member]        
Depreciation, Depletion and Amortization, Nonproduction, Total $ 800 $ 1,600    
DSM International B.V. [Member]        
Manufacturing Capacity Reservation Fee Current       24,400
Deferred Cost of Products Sold, Related Party 13,800     $ 3,300
Payments of Reservation Capacity Fees $ 7,300      
XML 44 R53.htm IDEA: XBRL DOCUMENT v3.19.3
Note 7 - Loss Per Share - Calculation of Basic and Diluted Net Loss Per Share of Common Stock (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Net loss $ (66,243) $ (92,802)
Less: losses allocated to participating securities 2,430 7,504
Net loss attributable to Amyris, Inc. common stockholders $ (63,813) $ (85,298)
Weighted-average shares of common stock outstanding used in computing loss per share of common stock, basic and diluted (in shares) 77,512,059 51,200,922
Loss per share attributable to common stockholders, basic and diluted (in dollars per share) $ (0.82) $ (1.67)
XML 45 R57.htm IDEA: XBRL DOCUMENT v3.19.3
Note 9 - Revenue Recognition and Contract Assets and Liabilities - Disaggregation of Revenue (Details) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Dec. 31, 2018
Revenues $ 14,374 $ 17,859 $ 17,859
Renewable Products [Member]      
Revenues 11,884 5,195 5,195
Licenses and Royalties [Member]      
Revenues 118 7,955 7,955
Grants and Collaborations [Member]      
Revenues 2,372 $ 4,709 4,709
UNITED STATES      
Revenues 7,566   3,171
UNITED STATES | Renewable Products [Member]      
Revenues 7,073   1,962
UNITED STATES | Licenses and Royalties [Member]      
Revenues  
UNITED STATES | Grants and Collaborations [Member]      
Revenues 493   1,209
Europe [Member]      
Revenues 4,601   13,889
Europe [Member] | Renewable Products [Member]      
Revenues 2,854   2,434
Europe [Member] | Licenses and Royalties [Member]      
Revenues 118   7,955
Europe [Member] | Grants and Collaborations [Member]      
Revenues 1,629   3,500
Asia [Member]      
Revenues 1,968   678
Asia [Member] | Renewable Products [Member]      
Revenues 1,718   678
Asia [Member] | Licenses and Royalties [Member]      
Revenues  
Asia [Member] | Grants and Collaborations [Member]      
Revenues 250  
South America [Member]      
Revenues 220   21
South America [Member] | Renewable Products [Member]      
Revenues 220   21
South America [Member] | Licenses and Royalties [Member]      
Revenues  
South America [Member] | Grants and Collaborations [Member]      
Revenues  
Other Area [Member]      
Revenues 19   100
Other Area [Member] | Renewable Products [Member]      
Revenues 19   100
Other Area [Member] | Licenses and Royalties [Member]      
Revenues  
Other Area [Member] | Grants and Collaborations [Member]      
Revenues  
XML 46 R63.htm IDEA: XBRL DOCUMENT v3.19.3
Note 10 - Related Party Transactions - Related Party Accounts Receivable (Details) - USD ($)
$ in Thousands
Mar. 31, 2019
Dec. 31, 2018
Accounts receivable, net $ 1,334 $ 1,349
Contract assets, current 8,021
Contract assets, noncurrent [1] 1,203 1,203
DSM International B.V. [Member]    
Accounts receivable, net 1,334 1,071
Contract assets, current 8,021
Contract assets, noncurrent 1,203 1,203
Novvi LLC [Member]    
Accounts receivable, net 188
Total [Member]    
Accounts receivable, net $ 90
[1] As of March 31, 2019 and December 31, 2018, contract liabilities, noncurrent is presented in Other Noncurrent Liabilities in the consolidated balance sheets because of its insignificance.
XML 47 R67.htm IDEA: XBRL DOCUMENT v3.19.3
Note 11 - Stock-based Compensation - Employee Service Share-based Compensation, Allocation of Recognized Period Costs (Details) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Allocated share-based compensation expense $ 3,452 $ 1,278
Research and Development Expense [Member]    
Allocated share-based compensation expense 663 363
Selling, General and Administrative Expenses [Member]    
Allocated share-based compensation expense $ 2,789 $ 915
XML 48 R44.htm IDEA: XBRL DOCUMENT v3.19.3
Note 3 - Fair Value Measurement - Convertible Debt (Details) - Long-term Debt [Member]
$ in Thousands
3 Months Ended
Mar. 31, 2019
USD ($)
Fair value $ 57,918
Change in fair value 2,130
Fair value $ 60,048
XML 49 R40.htm IDEA: XBRL DOCUMENT v3.19.3
Note 2 - Balance Sheet Details - Accrued and Other Current Liabilities (Details) - USD ($)
$ in Thousands
Mar. 31, 2019
Dec. 31, 2018
DSM manufacturing capacity fee $ 7,250
Contract termination fees 5,337 6,247
Accrued interest 7,094 3,853
Payroll and related expenses 5,285 9,220
Asset retirement obligation 3,111 3,063
Tax-related liabilities 2,589 2,139
Professional services 1,871 1,173
Other 1,054 3,284
Total accrued and other current liabilities $ 33,591 $ 28,979
XML 50 R48.htm IDEA: XBRL DOCUMENT v3.19.3
Note 4 - Debt - Long-term Debt Instruments (Details)
$ in Thousands
Mar. 31, 2019
USD ($)
2019 (remaining nine months) $ 176,485
2020 12,613
2021 62,922
2022 13,450
2023 399
Thereafter 2,268
Total future minimum payments 268,137
Less: amount representing interest (38,620)
Less: future conversion of accrued interest to principal (245)
Present value of minimum debt payments 229,272
Less: current portion of debt principal (155,973)
Noncurrent portion of debt principal 73,299
Convertible Debt [Member]  
2019 (remaining nine months) 139,303
2020
2021
2022
2023
Thereafter
Total future minimum payments 139,303
Less: amount representing interest (12,303)
Less: future conversion of accrued interest to principal (245)
Present value of minimum debt payments 126,755
Less: current portion of debt principal (126,755)
Noncurrent portion of debt principal
Loans Payable and Credit Facilities [Member]  
2019 (remaining nine months) 9,689
2020 10,113
2021 34,776
2022 13,450
2023 399
Thereafter 2,268
Total future minimum payments 70,695
Less: amount representing interest (17,883)
Less: future conversion of accrued interest to principal
Present value of minimum debt payments 52,812
Less: current portion of debt principal (4,513)
Noncurrent portion of debt principal 48,299
Related Party Convertible Notes [Member]  
2019 (remaining nine months) 25,618
2020
2021
2022
2023
Thereafter
Total future minimum payments 25,618
Less: amount representing interest (913)
Less: future conversion of accrued interest to principal
Present value of minimum debt payments 24,705
Less: current portion of debt principal (24,705)
Noncurrent portion of debt principal
Related Party Loans Payable and Credit Facilities [Member]  
2019 (remaining nine months) 1,875
2020 2,500
2021 28,146
2022
2023
Thereafter
Total future minimum payments 32,521
Less: amount representing interest (7,521)
Less: future conversion of accrued interest to principal
Present value of minimum debt payments 25,000
Less: current portion of debt principal
Noncurrent portion of debt principal $ 25,000
XML 51 R29.htm IDEA: XBRL DOCUMENT v3.19.3
Note 10 - Related Party Transactions (Tables)
3 Months Ended
Mar. 31, 2019
Notes Tables  
Schedule of Related Party Accounts Receivables [Table Text Block]
(In thousands)   March 31, 2019   December 31, 2018
Accounts receivable:                
DSM   $
1,334
    $
1,071
 
Novvi    
     
188
 
Total    
     
90
 
    $
1,334
    $
1,349
 
Accounts receivable, unbilled, current:                
DSM   $
    $
8,021
 
Accounts receivable, unbilled, noncurrent:                
DSM   $
1,203
    $
1,203
 
XML 53 R21.htm IDEA: XBRL DOCUMENT v3.19.3
Significant Accounting Policies (Policies)
3 Months Ended
Mar. 31, 2019
Accounting Policies [Abstract]  
Liquidity [Policy Text Block]
Going Concern
 
The Company has incurred significant operating losses since its inception and expects to continue to incur losses and negative cash flows from operations for at least the next
12
months following the issuance of these condensed consolidated financial statements. As of
March 
31,
2019,
the Company had negative working capital of
$199.4
million (compared to negative working capital of
$119.5
million as of
December 
31,
2018
), and an accumulated deficit of
$1.6
billion.
 
As of
March 
31,
2019,
the Company's debt (including related party debt), net of debt discount of
$13.5
million, totaled
$215.8
million, of which
$153.8
million is classified as current. Subsequent to
March 
31,
2019,
the Company entered into arrangements with lenders to extend maturities and convert certain debt obligations into common stock; see Note
12,
"Subsequent Events" for more information. The Company's debt service obligations through
March 
31,
2020
are
$179.8
million, including
$23.5
million of anticipated cash interest payments. The Company's debt agreements contain various covenants, including certain restrictions on the Company's business that could cause the Company to be at risk of defaults, such as restrictions on additional indebtedness and cross-default clauses. A failure to comply with, or cure non-compliance events or obtain waivers for covenant violations, and other provisions of the Company’s debt instruments, including any failure to make a payment when required, would generally result in events of default under such instruments, which could permit acceleration of such indebtedness. If such indebtedness is accelerated, it would generally also constitute an event of default under the Company’s other outstanding indebtedness, permitting acceleration of a substantial portion of the Company's outstanding indebtedness.
 
Cash and cash equivalents of
$5.2
million as of
March 
31,
2019
are
not
sufficient to fund expected future negative cash flows from operations and cash debt service obligations through
March 
31,
2020.
These factors raise substantial doubt about the Company’s ability to continue as a going concern within
one
year after the date that these condensed consolidated financial statements are issued. The condensed consolidated financial statements do
not
include any adjustments that might result from the outcome of this uncertainty. The Company's ability to continue as a going concern will depend, in large part, on its ability to extend existing debt maturities by restructuring a majority of its convertible debt, which is uncertain and outside the control of the Company. Further, the Company's operating plan for the
twelve
months ending
March 31, 2020
contemplates a significant reduction in its net operating cash outflows as compared to the year ended
December 
31,
2018,
resulting from (i) revenue growth from sales of existing and new products with positive gross margins, (ii) significantly increased cash inflows from grants and collaborations, and (iii) reduced production costs as a result of manufacturing and technical developments. If the Company is unable to complete these actions, it expects to be unable to meet its operating cash flow needs and its obligations under its existing debt facilities. This could result in an acceleration of its obligation to repay all amounts outstanding under those facilities, and it
may
be required to obtain additional equity or debt financing, which
may
not
occur timely or on reasonable terms, if at all, and/or liquidate its assets. In such a scenario, the value the Company receives for its assets in liquidation or dissolution could be significantly lower than the value reflected in these condensed consolidated financial statements.
 
On
September 16, 2019,
the Company failed to pay an aggregate of
$63.6
million of outstanding principal and accrued interest on the Second Exchange Note when due. The failure resulted in an event of default under the Second Exchange Note and also triggered cross-defaults under other debt instruments of the Company which permitted the holders of such indebtedness to accelerate the amounts owing under such instruments. The Company subsequently received waivers from substantially all holders of such other debt instruments to waive the right to accelerate. As a result, the indebtedness with respect to which the Company has obtained such waivers continues to be classified as long-term on the Company’s balance sheet.  The indebtedness reflected by the Second Exchange Note continues to be classified as a current liability on the Company’s balance sheet. In addition, as a result of the payment default, the conversion price of the Second Exchange Note is subject to adjustment in accordance with the terms of the Second Exchange Note.
 
The Company does
not
currently have sufficient funds to repay the amounts outstanding under the Second Exchange Note. To date, negotiations with the holder of the Second Exchange Note have
not
been successful, and there can be
no
assurance that a favorable outcome for the Company will be reached. The Company has executed a term sheet with an existing investor for a term loan, the proceeds of which would be used to repay a portion of the Second Exchange Note. However, there can be
no
assurance that the Company will be able to obtain such financing on its expected timeline, or on acceptable terms, if at all. Even if the Company does obtain such financing, it will
not
have sufficient funds to repay the Second Exchange Note in full without obtaining additional financing, which the Company is attempting to source. The condensed consolidated financial statements do
not
include any adjustments that might result from the outcome of this uncertainty.
Revenue from Contract with Customer [Policy Text Block]
Revenue Recognition
 
The Company recognizes revenue from the sale of renewable products, licenses of and royalties from intellectual property, and grants and collaborative research and development services. Revenue is measured based on the consideration specified in a contract with a customer and recognized when, or as, the Company satisfies a performance obligation by transferring control over a product or service to a customer. The Company generally does
not
incur costs to obtain new contracts. The costs to fulfill a contract are expensed as incurred.
 
The Company accounts for a contract when it has approval and commitment to perform from both parties, the rights of the parties are identified, payment terms are established, the contract has commercial substance and collectability of the consideration is probable. Changes to contracts are assessed for whether they represent a modification or should be accounted for as a new contract. The Company considers the following indicators among others when determining whether it is acting as a principal in the transaction and recording revenue on a gross basis: (i) the Company is primarily responsible for fulfilling the promise to provide the specified goods or service, (ii) the Company has inventory risk before the specified good or service has been transferred to a customer or after transfer of control to the customer and (iii) the Company has discretion in establishing the price for the specified good or service. If a transaction does
not
meet the Company's indicators of being a principal in the transaction, then the Company is acting as an agent in the transaction and the associated revenues are recognized on a net basis.
 
The Company’s significant contracts and contractual terms with its customers are presented in Note
10,
"Revenue Recognition" in Part II, Item
8
of the
2018
Form
10
-K/A.
 
The Company recognizes revenue when control has passed to the customer. The following indicators are evaluated in determining when control has passed to the customer: (i) the Company has a right to payment for the product or service, (ii) the customer has legal title to the product, (iii) the Company has transferred physical possession of the product to the customer, (iv) the customer has the significant risk and rewards of ownership of the product and (v) the customer has accepted the product. The Company’s renewable products are delivered to customers from the Company’s facilities with shipping terms typically specifying F.O.B. shipping point.
 
Performance Obligations
 
A performance obligation is a promise in a contract to transfer a distinct good or service to the customer. A contract’s transaction price is allocated to each distinct performance obligation and recognized as revenue when, or as, the performance obligation is satisfied. The Company's contracts
may
contain multiple performance obligations if a promise to transfer the individual goods or services is separately identifiable from other promises in the contracts and, therefore, is considered distinct. For contracts with multiple performance obligations, the Company determines the standalone selling price of each performance obligation and allocates the total transaction price using the relative selling price basis.
 
The following is a description of the principal goods and services from which the Company generates revenue.
 
Renewable Product Sales
 
Revenues from renewable product sales are recognized as a distinct performance obligation on a gross basis as the Company is acting as a principal in these transactions, with the selling price to the customer recorded net of discounts and allowances. Revenues are recognized at a point in time when control has passed to the customer, which typically is upon the renewable products leaving the Company’s facilities with the
first
transportation carrier. The Company, on occasion,
may
recognize revenue under a bill and hold arrangement, whereby the customer requests and agrees to purchase product but requests delivery at a later date. Under these arrangements, control transfers to the customer when the product is ready for delivery, which occurs when the product is identified separately as belonging to the customer, the product is ready for shipment to the customer in its current form, and the Company does
not
have the ability to direct the product to a different customer. It is at this point that the Company has the right to payment, the customer obtains legal title, and the customer has the significant risks and rewards of ownership. The Company’s renewable product sales do
not
include rights of return. Returns are accepted only if the product does
not
meet product specifications and such nonconformity is communicated to the Company within a set number of days of delivery. The Company offers a
two
-year assurance-type warranty to replace squalane products that do
not
meet Company-established criteria as set forth in the Company’s trade terms. An estimate of the cost to replace the squalane products sold is made based on a historical rate of experience and recognized as a liability and related expense when the renewable product sale is consummated.
 
Licenses and Royalties
 
Licensing of Intellectual Property:
When the Company’s intellectual property licenses are determined to be distinct from the other performance obligations identified in the arrangement, revenue is recognized from non-refundable, up-front fees allocated to the license at a point in time when the license is transferred to the licensee and the licensee is able to use and benefit from the license. For intellectual property licenses that are combined with other promises, the Company utilizes judgment to assess the nature of the combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purposes of recognizing revenue from non-refundable, up-front-fees. The Company evaluates the measure of progress each reporting period and, if necessary, adjusts the measure of performance and related revenue recognized.
 
Royalties from Licensing of Intellectual Property:
The Company earns royalties from the licensing of its intellectual property whereby the licensee uses the intellectual property to produce and sell its products to its customers and the Company shares in the profits.
 
When the Company’s intellectual property license is the only performance obligation, or it is the predominant performance obligation in arrangements with multiple performance obligations, the Company applies the sales-based royalty exception and revenue is estimated and recognized at a point in time when the licensee’s product sales occur. Estimates of sales-based royalty revenues are made using the most likely amount method, which is the single amount in a range of possible amounts derived from the licensee’s historical sales volumes and sales prices of its products and recent commodity market pricing data and trends.
 
When the Company’s intellectual property license is
not
the predominant performance obligation in arrangements with multiple performance obligations, the royalty represents variable consideration and is allocated to the transaction price of the predominant performance obligation which generally is the supply of renewable products to the Company's customers. Revenue is estimated and recognized at a point in time when the renewable products are delivered to the customer. Estimates of the amount of variable consideration to include in the transaction price are made using the expected value method, which is the sum of probability-weighted amounts in a range of possible amounts determined based on the cost to produce the renewable product plus a reasonable margin for the profit share. The Company only includes an amount of variable consideration in the transaction price to the extent it is probable that a significant reversal in the cumulative revenue recognized will
not
occur when the uncertainty associated with the variable consideration is subsequently resolved. Also, the transaction price is reduced for estimates of customer incentive payments payable by the Company for certain customer contracts.
 
Grants and Collaborative Research and Development Services
 
Collaborative Research and Development Services:
The Company earns revenues from collaboration agreements with customers to perform research and development services to develop new molecules using the Company’s technology and to scale production of the molecules for commercialization and use in the collaborator’s products. The collaboration agreements generally include providing the Company's collaborators with research and development services and with licenses to the Company’s intellectual property to use the technology underlying the development of the molecules and to sell its products that incorporate the technology. The terms of the Company's collaboration agreements typically include
one
or more of the following: advance payments for the research and development services that will be performed, nonrefundable upfront license payments, milestone payments to be received upon the achievement of the milestone events defined in the agreements, and royalty payments upon the commercialization of the molecules in which the Company shares in the customer’s profits.
 
Collaboration agreements are evaluated at inception to determine whether the intellectual property licenses represent distinct performance obligations separate from the research and development services. If the licenses are determined to be distinct, the non-refundable upfront license fee is recognized as revenue at a point in time when the license is transferred to the licensee and the licensee is able to use and benefit from the license while the research and development service fees are recognized over time as the performance obligations are satisfied. The research and development service fees represent variable consideration. Estimates of the amount of variable consideration to include in the transaction price are made using the expected value method, which is the sum of probability-weighted amounts in a range of possible amounts. The Company only includes an amount of variable consideration in the transaction price to the extent it is probable that a significant reversal in the cumulative revenue recognized will
not
occur when the uncertainty associated with the variable consideration is subsequently resolved. Revenue is recognized over time using either an input-based measure of labor hours expended or a time-based measure of progress towards the satisfaction of the performance obligations. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized.
 
Collaboration agreements that include milestone payments are evaluated at inception to determine whether the milestone events are considered probable of achievement and estimates are made of the amount of the milestone payments to include in the transaction price using the most likely amount method which is the single amount in a range of possible amounts. If it is probable that a significant revenue reversal will
not
occur, the estimated milestone payment amount is included in the transaction price. Each reporting period, the Company re-evaluates the probability of achievement of the milestone events and any related constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative basis, which would affect collaboration revenues in the period of adjustment. Generally, revenue is recognized using an input-based measure of progress towards the satisfaction of the performance obligations which can be labor hours expended or time-based in proportion to the estimated total project effort or total projected time to complete. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized. Certain performance obligations are associated with milestones agreed between the Company and its customer. Revenue generated from the performance of services in accordance with the milestones in these agreements is recognized upon confirmation from the customer that the milestone has been achieved. In these cases, amounts recognized are constrained to the amount of consideration received upon achievement of the milestone.
 
The Company generally invoices its collaborators on a monthly or quarterly basis, or upon the completion of the effort or achievement of a milestone, based on the terms of each agreement. Contract liability arises from amounts received in advance of performing the research and development activities and is recognized as revenue in future periods as the performance obligations are satisfied.
 
Grants:
The Company earns revenues from grants with government agencies to, among other things, provide research and development services to develop molecules using the Company’s technology, and create research and development tools to improve the timeline and predictability for scaling molecules from proof of concept to market by reducing time and costs. Grants typically consist of research and development milestone payments to be received upon the achievement of the milestone events defined in the agreements.
 
The milestone payments are evaluated at inception to determine whether the milestone events are considered probable of achievement and estimates are made of the amount of the milestone payments to include in the transaction price using the most likely amount method which is the single amount in a range of possible amounts. If it is probable that a significant revenue reversal will
not
occur, the estimated milestone payment amount is included in the transaction price. Each reporting period, the Company re-evaluates the probability of achievement of the milestone events and any related constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative basis, which would affect collaboration revenues in the period of adjustment. Revenue is recognized over time using a time-based measure of progress towards the satisfaction of the performance obligations. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized.
 
For descriptions of the Company's other significant accounting policies, see the
2018
Form
10
-K/A.
New Accounting Pronouncements, Policy [Policy Text Block]
Accounting Standards or Updates Recently Adopted
 
In the
three
months ended
March 
31,
2019,
the Company adopted these accounting standards or updates:
 
Leases
In
February 2016,
the FASB issued ASU
No.
 
2016
-
02,
Leases (Topic
842
).
The standard requires the recognition of lease liabilities and right-of-use (ROU) assets on the balance sheet arising from lease transactions at the lease commencement date and the disclosure of key information about leasing arrangements. In
July 2018,
the FASB issued ASU
2018
-
11,
Leases (Topic
842
) Targeted Improvements
, which provides an additional transition method in which the lease standard is applied at the adoption date and recognized as a cumulative-effect adjustment to retained earnings without adjustment to comparative periods (collectively Topic
842
). The amendment has the same effective date and transition requirements as the lease standard.
 
The Company adopted this standard on
January 1, 2019
using the modified retrospective approach and elected the package of practical expedients permitted under transition guidance, which allowed the Company to carry forward its historical assessments of: (
1
) whether contracts are or contain leases, (
2
) lease classification and (
3
) initial direct costs, where applicable. The Company did
not
elect the practical expedient allowing the use-of-hindsight which would require the Company to reassess the lease term of its leases based on all facts and circumstances through the effective date and did
not
elect the practical expedient pertaining to land easements as this is
not
applicable to the Company’s current contracts. The Company elected the post-transition practical expedient to
not
separate lease components from non-lease components for all leases of manufacturing equipment. The Company also elected a policy of
not
recording leases on its condensed consolidated balance sheets when the leases have a term of
12
months or less and the Company is
not
reasonably certain to elect an option to purchase the leased asset.
 
The adoption of this standard had the effect of increasing assets and liabilities on the condensed consolidated balance sheet by
$25.7
million, but did
not
have a material impact on the condensed consolidated statements of operations or cash flows.  The most significant impact relates to (
1
) the recognition of new ROU assets and lease liabilities on the balance sheet for operating leases; and (
2
) providing significant new disclosures about leasing activities.
 
Upon adoption, the Company recognized operating lease liabilities of
$33.6
million, based on the present value of the remaining minimum rental payments under current leasing standards for existing operating leases. The Company also recognized ROU assets of
$29.7
million, which represents the operating lease liability, adjusted for prepaid expenses and deferred rent. The difference between the operating lease ROU assets and lease liabilities reflects the net of advanced rent payments and deferred rent balances that were derecognized at the time of adoption.
 
Financial Instruments with "Down Round" Features
In
July 2017,
the FASB issued ASU
2017
-
11,
 
Earnings Per Share (Topic
260
); Distinguishing Liabilities from Equity (Topic
480
); Derivatives and Hedging (Topic
815
): Accounting for Certain Financial Instruments with Down Round Features
. The amendments of this ASU update the classification analysis of certain equity-linked financial instruments, or embedded features, with down round features, as well as clarify existing disclosure requirements for equity-classified instruments. When determining whether certain financial instruments should be classified as liabilities or equity instruments, a down round feature
no
longer precludes equity classification when assessing whether the instrument is indexed to an entity’s own stock. The accounting standard update became effective in the
first
quarter of fiscal year
2019,
and the Company adopted the standard using a modified retrospective approach. Since the adoption of ASU
2017
-
11
would have classified the warrants effected as equity at inception, the cumulative-effect adjustment should (i) record the issuance date value of the warrants as if they had been equity classified at the issuance date, (ii) reverse the effects of changes in the fair value of the warrants that had been recorded in the statement of operations of each period, and (iii) eliminate the derivative liabilities from the balance sheet. Upon adoption, the Company (i) recorded an increase of
$32.5
million to additional paid-in capital, (ii) recorded a decrease to accumulated deficit of
$8.5
million and (iii) decreased the warrant liability by
$41.0
million.
 
Recent Accounting Standards or Updates
Not
Yet Effective
 
Fair Value Measurement
In
August 2018,
the FASB issued ASU
2018
-
13,
Fair Value Measurement (Topic
820
): Disclosure Framework—Changes to the Disclosure Requirements for Fair Value Measurement
, which amends ASC
820,
Fair Value Measurement
. ASU
2018
-
13
modifies the disclosure requirements for fair value measurements by removing, modifying or adding certain disclosures. The accounting standard update will be effective beginning in the
first
quarter of fiscal
2020,
with removed and modified disclosures to be adopted on a retrospective basis, and new disclosures to be adopted on a prospective basis. The Company is in the initial stages of evaluating the impact of the standard on its condensed consolidated financial statements.
 
Collaborative Revenue Arrangements
In
November 2018,
the FASB issued ASU
2018
-
18,
Clarifying the Interaction between Topic
808
and Topic
606
, that clarifies the interaction between the guidance for certain collaborative arrangements and Topic
606,
the new revenue recognition standard. A collaborative arrangement is a contractual arrangement under which
two
or more parties actively participate in a joint operating activity and are exposed to significant risks and rewards that depend on the activity’s commercial success. The ASU provides guidance on how to assess whether certain transactions between collaborative arrangement participants should be accounted for within the revenue recognition standard. The accounting standard update will be effective beginning in the
first
quarter of fiscal year
2020
retroactively. The Company does
not
believe that the impact of the new standard on its condensed consolidated financial statements will be material.
 
Credit Losses
In
June 2016,
the FASB issued ASU
2016
-
13,
Financial Instruments—Credit Losses (Topic
326
), Measurement of Credit Losses on Financial Instruments
. ASU
2016
-
13
requires entities to measure all expected credit losses for most financial assets held at the reporting date based on an expected loss model which includes historical experience, current conditions, and reasonable and supportable forecasts. Entities will now use forward-looking information to better form their credit loss estimates. ASU
2016
-
13
also requires enhanced disclosures to help financial statement users better understand significant estimates and judgments used in estimating credit losses, as well as the credit quality and underwriting standards of an entity's portfolio. ASU
2016
-
13
will become effective for the Company beginning in the
first
quarter of fiscal year
2020.
The Company does
not
believe that the impact of the new standard on its condensed consolidated financial statements will be material.
Use of Estimates, Policy [Policy Text Block]
Use of Estimates and Judgements
 
The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates, judgements and assumptions that affect the reported amounts of assets and liabilities, disclosures of contingent assets and liabilities at the date of the condensed consolidated financial statements, and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates, and such differences
may
be material to the condensed consolidated financial statements.
XML 54 R25.htm IDEA: XBRL DOCUMENT v3.19.3
Note 5 - Mezzanine Equity (Tables)
3 Months Ended
Mar. 31, 2019
Notes Tables  
Mezzanine Equity Table [Table Text Block]
(In thousands)   March 31, 2019   December 31, 2018
Contingently redeemable common stock   $
5,000
    $
5,000
 
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Note 2 - Balance Sheet Details - Deferred Cost of Products Sold - Related Party (Details) - USD ($)
$ in Thousands
Mar. 31, 2019
Dec. 31, 2018
Deferred cost of products sold - related party $ 1,489 $ 489
Deferred cost of products sold, noncurrent - related party 9,001 2,828
Total $ 10,490 $ 3,317

XML 57 R30.htm IDEA: XBRL DOCUMENT v3.19.3
Note 11 - Stock-based Compensation (Tables)
3 Months Ended
Mar. 31, 2019
Notes Tables  
Share-based Payment Arrangement, Option and Stock Appreciation Rights, Activity [Table Text Block]
    Quantity of Stock Options   Weighted-
average
Exercise
Price
  Weighted-average
Remaining
Contractual
Life, in Years
  Aggregate
Intrinsic
Value, in Thousands
Outstanding - December 31, 2018    
5,390,270
    $
11.55
     
8.5
    $
29
 
Granted    
104,452
    $
4.73
     
 
     
 
 
Exercised    
(3,612
)   $
3.68
     
 
     
 
 
Forfeited or expired    
(63,726
)   $
14.27
     
 
     
 
 
Outstanding - March 31, 2019    
5,427,384
    $
11.39
     
8.3
    $
 
Vested or expected to vest after March 31, 2019    
4,874,155
    $
12.10
     
8.3
    $
 
Exercisable at March 31, 2019    
977,466
    $
39.20
     
5.8
    $
 
Share-based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block]
    Quantity of Restricted Stock Units   Weighted-average Grant-date Fair Value   Weighted-average Remaining Contractual Life, in Years
Outstanding - December 31, 2018    
5,294,803
    $
5.50
     
1.7
 
Awarded    
493,790
    $
4.65
     
 
 
RSUs released    
(192,795
)   $
6.55
     
 
 
RSUs forfeited    
(102,219
)   $
5.61
     
 
 
Outstanding - March 31, 2019    
5,493,579
    $
5.38
     
1.5
 
Vested or expected to vest after March 31, 2019    
5,153,107
    $
5.39
     
1.5
 
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
    Three Months Ended March 31,
(In thousands)   2019   2018
Research and development   $
663
    $
363
 
Sales, general and administrative    
2,789
     
915
 
Total stock-based compensation expense   $
3,452
    $
1,278
 
XML 58 R38.htm IDEA: XBRL DOCUMENT v3.19.3
Note 2 - Balance Sheet Details - Maturities of Financing and Operating Leases (Details) - USD ($)
$ in Thousands
Mar. 31, 2019
Dec. 31, 2018
2019 (remaining nine months), financing leases $ 368  
2019 (remaining nine months), operating leases 12,755  
2019 (remaining nine months), total leases 13,123  
2020, financing leases 199  
2020, operating leases 9,109  
2020, total leases 9,308  
2021, financing leases 1  
2021, operating leases 7,226  
2021, total leases 7,227  
2022, financing leases  
2022, operating leases 7,398  
2022, total leases 7,398  
2023, financing leases  
2023, operating leases 3,034  
2023, total leases 3,034  
Thereafter, financing leases  
Thereafter, operating leases  
Thereafter, total leases  
Total lease payments, financing leases 568  
Total lease payments, operating leases 39,522  
Total lease payments, total leases 40,090  
Less: amount representing interest (23)  
Less: amount representing interest (9,793)  
Less: amount representing interest (9,816)  
Total lease liability, financing leases 545  
Total lease liability, operating leases 29,729  
Total lease liability, total leases 30,274  
Current lease liability, financing leases 452  
Current lease liability, operating leases 10,972  
Current lease liability, total leases 11,424
Noncurrent lease liability, financing leases 93  
Noncurrent lease liability, operating leases 18,757  
Noncurrent lease liability, total leases 18,850
Total lease liability, financing leases 545  
Operating Lease, Liability, Total $ 29,729  
XML 59 R4.htm IDEA: XBRL DOCUMENT v3.19.3
Condensed Consolidated Statements of Operations (Unaudited) - USD ($)
3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Revenue:    
Revenues $ 14,374,000 $ 17,859,000
Cost and operating expenses:    
Cost of products sold 17,707,000 5,315,000
Research and development 17,839,000 17,825,000
Sales, general and administrative 28,253,000 18,100,000
Total cost and operating expenses 63,799,000 41,240,000
Loss from operations (49,425,000) (23,381,000)
Other income (expense):    
Loss on divestiture (1,778,000)
Interest expense (12,534,000) (9,978,000)
Loss from change in fair value of derivative instruments (2,039,000) (58,357,000)
Loss from change in fair value of debt (48,000)
Other income (expense), net (115,000) 692,000
Total other income (expense), net (16,818,000) (69,421,000)
Loss before income taxes (66,243,000) (92,802,000)
Provision for income taxes
Net loss attributable to Amyris, Inc. (66,243,000) (92,802,000)
Less: losses allocated to participating securities 2,430,000 7,504,000
Net loss attributable to Amyris, Inc. common stockholders $ (63,813,000) $ (85,298,000)
Loss per share attributable to common stockholders, basic and diluted (in dollars per share) $ (0.82) $ (1.67)
Weighted-average shares of common stock outstanding used in computing loss per share of common stock, basic and diluted (in shares) 77,512,059 51,200,922
Product [Member]    
Revenue:    
Revenues $ 11,884,000 $ 5,195,000
Licenses and Royalties [Member]    
Revenue:    
Revenues 118,000 7,955,000
Grants and Collaborations [Member]    
Revenue:    
Revenues $ 2,372,000 $ 4,709,000
XML 60 R13.htm IDEA: XBRL DOCUMENT v3.19.3
Note 5 - Mezzanine Equity
3 Months Ended
Mar. 31, 2019
Notes to Financial Statements  
Mezzanine Equity Disclosure [Text Block]
5.
Mezzanine Equity
 
Mezzanine equity is comprised of the following:
 
(In thousands)   March 31, 2019   December 31, 2018
Contingently redeemable common stock   $
5,000
    $
5,000
 
 
Mezzanine equity at
March 
31,
2019
and
December 
31,
2018
is comprised of proceeds from shares of common stock sold on
May 10, 2016
to the Bill & Melinda Gates Foundation (Gates Foundation). In connection with the stock sale, the Company and the Gates Foundation entered into an agreement under which the Company agreed to expend an aggregate amount
not
less than the proceeds from the stock sale to develop a yeast strain that produces artemisinic acid and/or amorphadiene at a low cost and to supply such artemisinic acid and amorphadiene to companies qualified to convert artemisinic acid and amorphadiene to artemisinin for inclusion in artemisinin combination therapies used to treat malaria. If the Company defaults in its obligation to use the proceeds from the stock sale as set forth above or defaults under certain other commitments in the agreement, the Gates Foundation will have the right to request that the Company redeem, or facilitate the purchase by a
third
party, the shares then held by the Gates Foundation at a price per share equal to the greater of (i) the closing price of the Company’s common stock on the trading day prior to the redemption or purchase, as applicable, or (ii) an amount equal to
$17.10
plus a compounded annual return of
10%.
 
As of
March 
31,
2019,
the Company's remaining research and development obligation under this arrangement was
$0.6
million.
XML 61 R17.htm IDEA: XBRL DOCUMENT v3.19.3
Note 9 - Revenue Recognition and Contract Assets and Liabilities
3 Months Ended
Mar. 31, 2019
Notes to Financial Statements  
Collaborative Arrangement Disclosure [Text Block]
9.
Revenue Recognition and Contract Assets and Liabilities
 
Disaggregation of Revenue
 
The following table presents revenue by major product and service, as well as by primary geographical market, based on the location of the customer:
 
    Three Months Ended March 31,
(In thousands)
  2019   2018
    Renewable Products   Licenses and Royalties   Grants and Collaborations   Total   Renewable Products   Licenses and Royalties   Grants and Collaborations   Total
United States   $
7,073
    $
    $
493
    $
7,566
    $
1,962
    $
    $
1,209
    $
3,171
 
Europe    
2,854
     
118
     
1,629
     
4,601
     
2,434
     
7,955
     
3,500
     
13,889
 
Asia    
1,718
     
     
250
     
1,968
     
678
     
     
     
678
 
South America    
220
     
     
     
220
     
21
     
     
     
21
 
Other    
19
     
     
     
19
     
100
     
     
     
100
 
    $
11,884
    $
118
    $
2,372
    $
14,374
    $
5,195
    $
7,955
    $
4,709
    $
17,859
 
 
Significant Revenue Agreements During the Three Months Ended
March 
31,
2019
 
In
connection with significant revenue agreements, the Company recognized the following revenues for the
three
months ended
March 
31,
2019
and
2018
:
 
 
    Three Months Ended March 31,
(In thousands)
  2019   2018
    Renewable Products   Licenses and Royalties   Grants and Collaborations   Total   Renewable Products   Licenses and Royalties   Grants and Collaborations   Total
Firmenich   $
1,891
    $
498
    $
728
    $
3,117
    $
207
    $
37
    $
1,267
    $
1,511
 
Givaudan    
1,575
     
     
     
1,575
     
1,076
     
     
1,500
     
2,576
 
American Sugar Refining    
1,494
     
     
     
1,494
     
     
     
     
 
DSM - related party    
2
     
(380
)    
396
     
18
     
     
7,918
     
734
     
8,652
 
Subtotal revenue from significant revenue agreements    
4,962
     
118
     
1,124
     
6,204
     
1,283
     
7,955
     
3,501
     
12,739
 
Revenue from all other customers    
6,922
     
     
1,248
     
8,170
     
3,912
     
     
1,208
     
5,120
 
Total revenue from all customers   $
11,884
    $
118
    $
2,372
    $
14,374
    $
5,195
    $
7,955
    $
4,709
    $
17,859
 
 
Contract Assets and Liabilities
 
When a contract results in revenue being recognized in excess of the amount the Company has invoiced or has the right to invoice to the customer, a contract asset is recognized. Contract assets are transferred to accounts receivable, net when the rights to the consideration become unconditional.
 
Contract liabilities consist of payments received from customers, or such consideration that is contractually due, in advance of providing the product or performing services such that control has
not
passed to the customer.
 
Trade receivables related to revenue from contracts with customers are included in accounts receivable on the condensed consolidated balance sheets, net of the allowance for doubtful accounts. Trade accounts receivable are recorded at the point of renewable product sale or in accordance with the contractual payment terms for licenses and royalties, and grants and collaborative research and development services for the amount payable by the customer to the Company for sale of goods or the performance of services.
 
Contract Balances
 
The following table provides information about accounts receivable and contract liabilities from contracts with customers:
 
(In thousands)
  March 31, 2019   December 31, 2018
Accounts receivable, net   $
10,968
    $
16,003
 
Accounts receivable - related party, net   $
1,334
    $
1,349
 
Accounts receivable, unbilled - related party   $
    $
8,021
 
Accounts receivable, unbilled, noncurrent - related party   $
1,203
    $
1,203
 
Contract liabilities   $
8,333
    $
8,236
 
Contract liabilities, noncurrent
(1)
  $
1,449
    $
1,587
 
 
(
1
)    
As of
March 
31,
2019
and
December 
31,
2018,
contract liabilities, noncurrent is presented in Other Noncurrent Liabilities in the condensed consolidated balance sheets because of its insignificance.
 
Unbilled receivables at the end of the period relate to the Company’s right to consideration from DSM for performance fees. The Company’s right to cash receipt for these minimum royalty amounts occurs on or before
December 31, 2019.
From
December 
31,
2018
to
March 
31,
2019,
the combination of current and noncurrent unbilled receivables decreased by
$8.0
million as the result of invoices issued to DSM during the period. An
$8.0
million unbilled accounts receivable was originally due on
December 31, 2019
but was paid early by DSM. The
$0.6
million difference between the original amount due and the
$7.4
million cash payment received was recorded as a
$0.4
million reduction of licenses and royalties revenue during the quarter and a
$0.2
million reduction to interest income.
 
Remaining Performance Obligations
 
The following table provides information regarding the estimated revenue expected to be recognized in the future related to performance obligations that are unsatisfied (or partially unsatisfied) based on the Company's existing agreements with customers as of
March 
31,
2019.
 
(In thousands)   As of March 31, 2019
Remaining 2019   $
23,920
 
2020    
38,508
 
2021    
31,172
 
2022 and thereafter    
 
Total from all customers   $
93,600
 
 
In accordance with the disclosure provisions of ASC
606,
the table above excludes estimated future revenues for performance obligations that are part of a contract that has an original expected duration of
one
year or less or a performance obligation with variable consideration that is recognized using the sales-based royalty exception for licenses of intellectual property. Additionally, approximately
$17.6
million of estimated future revenue is excluded from the table above, as that amount represents constrained variable consideration.
XML 62 R8.htm IDEA: XBRL DOCUMENT v3.19.3
Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
3 Months Ended 12 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Dec. 31, 2018
Operating activities      
Net loss $ (66,243,000) $ (92,802,000)  
Adjustments to reconcile net loss to net cash used in operating activities:      
Amortization of debt discount 4,628,000 4,789,000  
Stock-based compensation 3,452,000 1,278,000  
Loss from change in fair value of debt 48,000 $ (2,082,000)
Loss from change in fair value of derivative liabilities 2,039,000 58,357,000  
Amortization of right-of-use assets under operating leases 2,826,000  
Depreciation and amortization 848,000 1,561,000  
Write-down of property, plant and equipment 438,000  
Loss on disposal of property, plant and equipment 1,000 1,035,000  
(Gain) loss on foreign currency exchange rates (108,000) 243,000  
Changes in assets and liabilities:      
Accounts receivable 5,048,000 74,000  
Accounts receivable, unbilled - related party 8,021,000 93,000  
Inventories 1,196,000 420,000  
Deferred cost of products sold (7,173,000)  
Prepaid expenses and other assets 1,766,000 6,747,000  
Accounts payable 1,834,000 (108,000)  
Accrued and other liabilities 6,245,000 (11,120,000)  
Lease liabilities (4,036,000)  
Contract liabilities 108,000 4,264,000  
Net cash used in operating activities (36,980,000) (25,169,000)  
Investing activities      
Purchases of property, plant and equipment (3,046,000) (1,584,000)  
Net cash used in investing activities (3,046,000) (1,584,000)  
Financing activities      
Proceeds from issuance of debt, net of issuance costs 484,000  
Proceeds from exercises of common stock options 13,000 81,000  
Proceeds from exercises of warrants 1,000 133,000  
Payment of minimum employee taxes withheld upon net share settlement of restricted stock units (9,000) (66,000)  
Principal payments on financing leases (134,000) (400,000)  
Principal payments on debt (577,000) (6,534,000)  
Proceeds from issuance of common stock in private placements, net of issuance costs 92,000  
Net cash used in financing activities (222,000) (6,694,000)  
Effect of exchange rate changes on cash, cash equivalents and restricted cash (70,000) (68,000)  
Net decrease in cash, cash equivalents and restricted cash (40,318,000) (33,515,000)  
Cash, cash equivalents and restricted cash at beginning of period 47,054,000 61,012,000 61,012,000
Cash, cash equivalents and restricted cash at end of the period 6,736,000 27,497,000 47,054,000
Cash and cash equivalents 5,153,000 24,084,000 45,353,000
Restricted cash, current 623,000 2,454,000 741,000
Restricted cash, noncurrent 960,000 959,000 $ 960,000
Supplemental disclosures of cash flow information:      
Cash paid for interest 3,099,000 1,815,000  
Supplemental disclosures of non-cash investing and financing activities:      
Right-of-use assets under operating leases recorded upon adoption of ASC 842 (Note 2) 29,713,000  
Lease liabilities recorded upon adoption of ASC 842 (Note 2) 33,552,000  
Cumulative effect of change in accounting principle for ASU 2017-11 (Note 2) 41,043,000  
Acquisition of property, plant and equipment under accounts payable, accrued liabilities and notes payable 605,000 264,000  
Acquisition of right-of-use assets under operating leases 758,000  
Right-of-use assets amortization capitalized into inventory 1,800,000  
Accrued interest added to debt principal 448,000 1,211,000  
Fair value of warrants recorded as debt discount in connection with debt modification 398,000  
Financing of equipment $ 91,000  
XML 63 R59.htm IDEA: XBRL DOCUMENT v3.19.3
Note 9 - Revenue Recognition and Contract Assets and Liabilities - Contract Balances (Details) - USD ($)
$ in Thousands
Mar. 31, 2019
Dec. 31, 2018
Accounts receivable, net $ 10,968 $ 16,003
Accounts receivable - related party, net 1,334 1,349
Accounts receivable, unbilled - related party 8,021
Accounts receivable, unbilled, noncurrent - related party [1] 1,203 1,203
Contract liabilities 8,333 8,236
Contract liabilities, noncurrent(1) [1] $ 1,449 $ 1,587
[1] As of March 31, 2019 and December 31, 2018, contract liabilities, noncurrent is presented in Other Noncurrent Liabilities in the consolidated balance sheets because of its insignificance.
XML 64 R51.htm IDEA: XBRL DOCUMENT v3.19.3
Note 6 - Stockholders' Deficit (Details Textual) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Stock Issued During Period, Shares, Warrants Exercised 479,751  
Proceeds from Warrant Exercises $ 1 $ 133
August 2017 Vito Dilution Warrants [Member]    
Stock Issued During Period, Shares, Warrants Exercised 479,751  
Class of Warrant or Right, Exercise Price of Warrants or Rights $ 0.01  
Proceeds from Warrant Exercises $ 0  
Stock Issued During Period, Shares, Warrants Exercised Through Net Share Settlement 450,568  
XML 65 R55.htm IDEA: XBRL DOCUMENT v3.19.3
Note 9 - Revenue Recognition and Contract Assets and Liabilities 1 (Details Textual) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Contract with Customer, Asset, Reclassified to Receivable $ 8,000  
Cost of Goods and Services Sold, Total 17,707 $ 5,315
Interest Expense, Total 12,534 $ 9,978
Revenue, Remaining Performance Obligation, Constrained Variable Consideration, Amount 17,600  
DSM International B.V. [Member]    
Contract with Customer, Asset, Cumulative Catch-up Adjustment to Revenue, Change in Estimate of Transaction Price 600  
Proceeds from Customers 7,400  
Interest Expense, Total 200  
DSM International B.V. [Member] | Licenses and Royalties [Member]    
Cost of Goods and Services Sold, Total $ 400  
XML 66 R39.htm IDEA: XBRL DOCUMENT v3.19.3
Note 2 - Balance Sheet Details - Other Assets (Details) - USD ($)
$ in Thousands
Mar. 31, 2019
Dec. 31, 2018
Contingent consideration $ 4,286 $ 4,286
Deposits 145 2,465
Other 1,117 1,207
Other assets $ 5,548 $ 7,958
XML 67 R35.htm IDEA: XBRL DOCUMENT v3.19.3
Note 2 - Balance Sheet Details - Prepaid Expenses and Other Current Assets (Details) - USD ($)
$ in Thousands
Mar. 31, 2019
Dec. 31, 2018
Prepayments, advances and deposits $ 3,310 $ 5,644
Recoverable taxes from Brazilian government entities 956 631
Other 3,949 4,291
Total prepaid expenses and other current assets $ 8,215 $ 10,566
XML 68 R31.htm IDEA: XBRL DOCUMENT v3.19.3
Note 1 - Basis of Presentation and Summary of Significant Accounting Policies (Details Textual) - USD ($)
Jan. 01, 2019
Sep. 16, 2019
Mar. 31, 2019
Dec. 31, 2018
Working Capital     $ (199,400,000) $ (119,500,000)
Retained Earnings (Accumulated Deficit), Ending Balance     (1,579,129,000) (1,521,417,000)
Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net, Total     13,500,000  
Long-term Debt, Total     215,827,000 209,697,000
Long-term Debt, Current Maturities, Including Due to Related Parties     153,752,000 147,677,000
Long-term Debt, Current Maturities Due Within 60 Days, Including Due to Related Parties     179,800,000  
Long-term Debt, Current Maturities Due Within 60 Days, Including Due to Related Parties, Anticipated Interest Portion     23,500,000  
Cash, Cash Equivalents, and Short-term Investments, Total     5,200,000  
Assets, Total     105,147,000 127,925,000
Operating Lease, Liability, Total     29,729,000  
Operating Lease, Right-of-Use Asset $ 800,000   27,645,000
Liabilities, Total     $ 337,347,000 $ 339,744,000
Accounting Standards Update 2016-02 [Member]        
Assets, Total 25,700,000      
Operating Lease, Liability, Total 33,600,000      
Operating Lease, Right-of-Use Asset 29,700,000      
Liabilities, Total 24,900,000      
Accounting Standards Update 2017-11 [Member]        
Retained Earnings (Accumulated Deficit), Ending Balance (8,500,000)      
Additional Paid in Capital, Ending Balance 32,500,000      
Increase (Decrease) in Derivative Liabilities $ (41,000,000)      
Convertible Senior Notes, 6.0%, Due in 2021, Second Exchange [Member] | Subsequent Event [Member]        
Debt Instrument, Debt Default, Amount   $ 63,600,000    
XML 69 R9.htm IDEA: XBRL DOCUMENT v3.19.3
Note 1 - Basis of Presentation and Summary of Significant Accounting Policies
3 Months Ended
Mar. 31, 2019
Notes to Financial Statements  
Significant Accounting Policies [Text Block]
1.
Basis of Presentation and Summary of Significant Accounting Policies
 
Amyris, Inc. (Amyris or the Company) is a leading industrial biotechnology company that applies its technology platform to engineer, manufacture and sell high performance, natural, sustainably-sourced products into the Health & Wellness, Clean Beauty, and Flavor & Fragrance markets. The Company's proven technology platform enables the Company to rapidly engineer microbes and use them as catalysts to metabolize renewable, plant-sourced sugars into large volume, high-value ingredients. The Company's biotechnology platform and industrial fermentation process replace existing complex and expensive manufacturing processes. The Company has successfully used its technology to develop and produce several distinct molecules at commercial volumes.
 
The accompanying unaudited condensed consolidated financial statements of Amyris, Inc. should be read in conjunction with the audited consolidated financial statements and notes thereto included in the Company's Annual Report on Form
10
-K/A for the year ended
December 
31,
2018
(the
2018
Form
10
-K/A), from which the condensed consolidated balance sheet as of
December 
31,
2018
is derived. The accompanying condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (U.S. GAAP) for interim financial information and with the instructions to Form
10
-Q and Article
10
of Regulation S-
X.
Accordingly, since they are interim statements, the accompanying condensed consolidated financial statements do
not
include all of the information and notes required by U.S. GAAP for complete financial statements. The accompanying condensed consolidated financial statements reflect all adjustments, consisting of normal recurring adjustments, that are, in the opinion of management, necessary to a fair statement of the results for the interim periods presented. Interim results are
not
necessarily indicative of results for a full year.
 
Going Concern
 
The Company has incurred significant operating losses since its inception and expects to continue to incur losses and negative cash flows from operations for at least the next
12
months following the issuance of these condensed consolidated financial statements. As of
March 
31,
2019,
the Company had negative working capital of
$199.4
million (compared to negative working capital of
$119.5
million as of
December 
31,
2018
), and an accumulated deficit of
$1.6
billion.
 
As of
March 
31,
2019,
the Company's debt (including related party debt), net of debt discount of
$13.5
million, totaled
$215.8
million, of which
$153.8
million is classified as current. Subsequent to
March 
31,
2019,
the Company entered into arrangements with lenders to extend maturities and convert certain debt obligations into common stock; see Note
12,
"Subsequent Events" for more information. The Company's debt service obligations through
March 
31,
2020
are
$179.8
million, including
$23.5
million of anticipated cash interest payments. The Company's debt agreements contain various covenants, including certain restrictions on the Company's business that could cause the Company to be at risk of defaults, such as restrictions on additional indebtedness and cross-default clauses. A failure to comply with, or cure non-compliance events or obtain waivers for covenant violations, and other provisions of the Company’s debt instruments, including any failure to make a payment when required, would generally result in events of default under such instruments, which could permit acceleration of such indebtedness. If such indebtedness is accelerated, it would generally also constitute an event of default under the Company’s other outstanding indebtedness, permitting acceleration of a substantial portion of the Company's outstanding indebtedness.
 
Cash and cash equivalents of
$5.2
million as of
March 
31,
2019
are
not
sufficient to fund expected future negative cash flows from operations and cash debt service obligations through
March 
31,
2020.
These factors raise substantial doubt about the Company’s ability to continue as a going concern within
one
year after the date that these condensed consolidated financial statements are issued. The condensed consolidated financial statements do
not
include any adjustments that might result from the outcome of this uncertainty. The Company's ability to continue as a going concern will depend, in large part, on its ability to extend existing debt maturities by restructuring a majority of its convertible debt, which is uncertain and outside the control of the Company. Further, the Company's operating plan for the
twelve
months ending
March 31, 2020
contemplates a significant reduction in its net operating cash outflows as compared to the year ended
December 
31,
2018,
resulting from (i) revenue growth from sales of existing and new products with positive gross margins, (ii) significantly increased cash inflows from grants and collaborations, and (iii) reduced production costs as a result of manufacturing and technical developments. If the Company is unable to complete these actions, it expects to be unable to meet its operating cash flow needs and its obligations under its existing debt facilities. This could result in an acceleration of its obligation to repay all amounts outstanding under those facilities, and it
may
be required to obtain additional equity or debt financing, which
may
not
occur timely or on reasonable terms, if at all, and/or liquidate its assets. In such a scenario, the value the Company receives for its assets in liquidation or dissolution could be significantly lower than the value reflected in these condensed consolidated financial statements.
 
On
September 16, 2019,
the Company failed to pay an aggregate of
$63.6
million of outstanding principal and accrued interest on the Second Exchange Note when due. The failure resulted in an event of default under the Second Exchange Note and also triggered cross-defaults under other debt instruments of the Company which permitted the holders of such indebtedness to accelerate the amounts owing under such instruments. The Company subsequently received waivers from substantially all holders of such other debt instruments to waive the right to accelerate. As a result, the indebtedness with respect to which the Company has obtained such waivers continues to be classified as long-term on the Company’s balance sheet.  The indebtedness reflected by the Second Exchange Note continues to be classified as a current liability on the Company’s balance sheet. In addition, as a result of the payment default, the conversion price of the Second Exchange Note is subject to adjustment in accordance with the terms of the Second Exchange Note.
 
The Company does
not
currently have sufficient funds to repay the amounts outstanding under the Second Exchange Note. To date, negotiations with the holder of the Second Exchange Note have
not
been successful, and there can be
no
assurance that a favorable outcome for the Company will be reached. The Company has executed a term sheet with an existing investor for a term loan, the proceeds of which would be used to repay a portion of the Second Exchange Note. However, there can be
no
assurance that the Company will be able to obtain such financing on its expected timeline, or on acceptable terms, if at all. Even if the Company does obtain such financing, it will
not
have sufficient funds to repay the Second Exchange Note in full without obtaining additional financing, which the Company is attempting to source. The condensed consolidated financial statements do
not
include any adjustments that might result from the outcome of this uncertainty.
 
Significant Accounting Policies
 
Note
1,
"Basis of Presentation and Summary of Significant Accounting Policies", to the audited consolidated financial statements in the
2018
Form
10
-K/A includes a discussion of the significant accounting policies and estimates used in the preparation of the Company’s consolidated financial statements. There have been
no
material changes to the Company's significant accounting policies and estimates during the
three
months ended
March 
31,
2019,
except for the Company's adoption of these accounting standards on
January 1, 2019:
    
Accounting Standards Codification (ASC) Topic
842
(ASC
842
),
Leases;
and
    
Accounting Standards Update (ASU)
2017
-
11,
 Earnings Per Share (Topic
260
); Distinguishing Liabilities from Equity (Topic
480
); Derivatives and Hedging (Topic
815
): Accounting for Certain Financial Instruments with Down Round Features
 
Revenue Recognition
 
The Company recognizes revenue from the sale of renewable products, licenses of and royalties from intellectual property, and grants and collaborative research and development services. Revenue is measured based on the consideration specified in a contract with a customer and recognized when, or as, the Company satisfies a performance obligation by transferring control over a product or service to a customer. The Company generally does
not
incur costs to obtain new contracts. The costs to fulfill a contract are expensed as incurred.
 
The Company accounts for a contract when it has approval and commitment to perform from both parties, the rights of the parties are identified, payment terms are established, the contract has commercial substance and collectability of the consideration is probable. Changes to contracts are assessed for whether they represent a modification or should be accounted for as a new contract. The Company considers the following indicators among others when determining whether it is acting as a principal in the transaction and recording revenue on a gross basis: (i) the Company is primarily responsible for fulfilling the promise to provide the specified goods or service, (ii) the Company has inventory risk before the specified good or service has been transferred to a customer or after transfer of control to the customer and (iii) the Company has discretion in establishing the price for the specified good or service. If a transaction does
not
meet the Company's indicators of being a principal in the transaction, then the Company is acting as an agent in the transaction and the associated revenues are recognized on a net basis.
 
The Company’s significant contracts and contractual terms with its customers are presented in Note
10,
"Revenue Recognition" in Part II, Item
8
of the
2018
Form
10
-K/A.
 
The Company recognizes revenue when control has passed to the customer. The following indicators are evaluated in determining when control has passed to the customer: (i) the Company has a right to payment for the product or service, (ii) the customer has legal title to the product, (iii) the Company has transferred physical possession of the product to the customer, (iv) the customer has the significant risk and rewards of ownership of the product and (v) the customer has accepted the product. The Company’s renewable products are delivered to customers from the Company’s facilities with shipping terms typically specifying F.O.B. shipping point.
 
Performance Obligations
 
A performance obligation is a promise in a contract to transfer a distinct good or service to the customer. A contract’s transaction price is allocated to each distinct performance obligation and recognized as revenue when, or as, the performance obligation is satisfied. The Company's contracts
may
contain multiple performance obligations if a promise to transfer the individual goods or services is separately identifiable from other promises in the contracts and, therefore, is considered distinct. For contracts with multiple performance obligations, the Company determines the standalone selling price of each performance obligation and allocates the total transaction price using the relative selling price basis.
 
The following is a description of the principal goods and services from which the Company generates revenue.
 
Renewable Product Sales
 
Revenues from renewable product sales are recognized as a distinct performance obligation on a gross basis as the Company is acting as a principal in these transactions, with the selling price to the customer recorded net of discounts and allowances. Revenues are recognized at a point in time when control has passed to the customer, which typically is upon the renewable products leaving the Company’s facilities with the
first
transportation carrier. The Company, on occasion,
may
recognize revenue under a bill and hold arrangement, whereby the customer requests and agrees to purchase product but requests delivery at a later date. Under these arrangements, control transfers to the customer when the product is ready for delivery, which occurs when the product is identified separately as belonging to the customer, the product is ready for shipment to the customer in its current form, and the Company does
not
have the ability to direct the product to a different customer. It is at this point that the Company has the right to payment, the customer obtains legal title, and the customer has the significant risks and rewards of ownership. The Company’s renewable product sales do
not
include rights of return. Returns are accepted only if the product does
not
meet product specifications and such nonconformity is communicated to the Company within a set number of days of delivery. The Company offers a
two
-year assurance-type warranty to replace squalane products that do
not
meet Company-established criteria as set forth in the Company’s trade terms. An estimate of the cost to replace the squalane products sold is made based on a historical rate of experience and recognized as a liability and related expense when the renewable product sale is consummated.
 
Licenses and Royalties
 
Licensing of Intellectual Property:
When the Company’s intellectual property licenses are determined to be distinct from the other performance obligations identified in the arrangement, revenue is recognized from non-refundable, up-front fees allocated to the license at a point in time when the license is transferred to the licensee and the licensee is able to use and benefit from the license. For intellectual property licenses that are combined with other promises, the Company utilizes judgment to assess the nature of the combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purposes of recognizing revenue from non-refundable, up-front-fees. The Company evaluates the measure of progress each reporting period and, if necessary, adjusts the measure of performance and related revenue recognized.
 
Royalties from Licensing of Intellectual Property:
The Company earns royalties from the licensing of its intellectual property whereby the licensee uses the intellectual property to produce and sell its products to its customers and the Company shares in the profits.
 
When the Company’s intellectual property license is the only performance obligation, or it is the predominant performance obligation in arrangements with multiple performance obligations, the Company applies the sales-based royalty exception and revenue is estimated and recognized at a point in time when the licensee’s product sales occur. Estimates of sales-based royalty revenues are made using the most likely amount method, which is the single amount in a range of possible amounts derived from the licensee’s historical sales volumes and sales prices of its products and recent commodity market pricing data and trends.
 
When the Company’s intellectual property license is
not
the predominant performance obligation in arrangements with multiple performance obligations, the royalty represents variable consideration and is allocated to the transaction price of the predominant performance obligation which generally is the supply of renewable products to the Company's customers. Revenue is estimated and recognized at a point in time when the renewable products are delivered to the customer. Estimates of the amount of variable consideration to include in the transaction price are made using the expected value method, which is the sum of probability-weighted amounts in a range of possible amounts determined based on the cost to produce the renewable product plus a reasonable margin for the profit share. The Company only includes an amount of variable consideration in the transaction price to the extent it is probable that a significant reversal in the cumulative revenue recognized will
not
occur when the uncertainty associated with the variable consideration is subsequently resolved. Also, the transaction price is reduced for estimates of customer incentive payments payable by the Company for certain customer contracts.
 
Grants and Collaborative Research and Development Services
 
Collaborative Research and Development Services:
The Company earns revenues from collaboration agreements with customers to perform research and development services to develop new molecules using the Company’s technology and to scale production of the molecules for commercialization and use in the collaborator’s products. The collaboration agreements generally include providing the Company's collaborators with research and development services and with licenses to the Company’s intellectual property to use the technology underlying the development of the molecules and to sell its products that incorporate the technology. The terms of the Company's collaboration agreements typically include
one
or more of the following: advance payments for the research and development services that will be performed, nonrefundable upfront license payments, milestone payments to be received upon the achievement of the milestone events defined in the agreements, and royalty payments upon the commercialization of the molecules in which the Company shares in the customer’s profits.
 
Collaboration agreements are evaluated at inception to determine whether the intellectual property licenses represent distinct performance obligations separate from the research and development services. If the licenses are determined to be distinct, the non-refundable upfront license fee is recognized as revenue at a point in time when the license is transferred to the licensee and the licensee is able to use and benefit from the license while the research and development service fees are recognized over time as the performance obligations are satisfied. The research and development service fees represent variable consideration. Estimates of the amount of variable consideration to include in the transaction price are made using the expected value method, which is the sum of probability-weighted amounts in a range of possible amounts. The Company only includes an amount of variable consideration in the transaction price to the extent it is probable that a significant reversal in the cumulative revenue recognized will
not
occur when the uncertainty associated with the variable consideration is subsequently resolved. Revenue is recognized over time using either an input-based measure of labor hours expended or a time-based measure of progress towards the satisfaction of the performance obligations. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized.
 
Collaboration agreements that include milestone payments are evaluated at inception to determine whether the milestone events are considered probable of achievement and estimates are made of the amount of the milestone payments to include in the transaction price using the most likely amount method which is the single amount in a range of possible amounts. If it is probable that a significant revenue reversal will
not
occur, the estimated milestone payment amount is included in the transaction price. Each reporting period, the Company re-evaluates the probability of achievement of the milestone events and any related constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative basis, which would affect collaboration revenues in the period of adjustment. Generally, revenue is recognized using an input-based measure of progress towards the satisfaction of the performance obligations which can be labor hours expended or time-based in proportion to the estimated total project effort or total projected time to complete. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized. Certain performance obligations are associated with milestones agreed between the Company and its customer. Revenue generated from the performance of services in accordance with the milestones in these agreements is recognized upon confirmation from the customer that the milestone has been achieved. In these cases, amounts recognized are constrained to the amount of consideration received upon achievement of the milestone.
 
The Company generally invoices its collaborators on a monthly or quarterly basis, or upon the completion of the effort or achievement of a milestone, based on the terms of each agreement. Contract liability arises from amounts received in advance of performing the research and development activities and is recognized as revenue in future periods as the performance obligations are satisfied.
 
Grants:
The Company earns revenues from grants with government agencies to, among other things, provide research and development services to develop molecules using the Company’s technology, and create research and development tools to improve the timeline and predictability for scaling molecules from proof of concept to market by reducing time and costs. Grants typically consist of research and development milestone payments to be received upon the achievement of the milestone events defined in the agreements.
 
The milestone payments are evaluated at inception to determine whether the milestone events are considered probable of achievement and estimates are made of the amount of the milestone payments to include in the transaction price using the most likely amount method which is the single amount in a range of possible amounts. If it is probable that a significant revenue reversal will
not
occur, the estimated milestone payment amount is included in the transaction price. Each reporting period, the Company re-evaluates the probability of achievement of the milestone events and any related constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative basis, which would affect collaboration revenues in the period of adjustment. Revenue is recognized over time using a time-based measure of progress towards the satisfaction of the performance obligations. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized.
 
For descriptions of the Company's other significant accounting policies, see the
2018
Form
10
-K/A.
 
Accounting Standards or Updates Recently Adopted
 
In the
three
months ended
March 
31,
2019,
the Company adopted these accounting standards or updates:
 
Leases
In
February 2016,
the FASB issued ASU
No.
 
2016
-
02,
Leases (Topic
842
).
The standard requires the recognition of lease liabilities and right-of-use (ROU) assets on the balance sheet arising from lease transactions at the lease commencement date and the disclosure of key information about leasing arrangements. In
July 2018,
the FASB issued ASU
2018
-
11,
Leases (Topic
842
) Targeted Improvements
, which provides an additional transition method in which the lease standard is applied at the adoption date and recognized as a cumulative-effect adjustment to retained earnings without adjustment to comparative periods (collectively Topic
842
). The amendment has the same effective date and transition requirements as the lease standard.
 
The Company adopted this standard on
January 1, 2019
using the modified retrospective approach and elected the package of practical expedients permitted under transition guidance, which allowed the Company to carry forward its historical assessments of: (
1
) whether contracts are or contain leases, (
2
) lease classification and (
3
) initial direct costs, where applicable. The Company did
not
elect the practical expedient allowing the use-of-hindsight which would require the Company to reassess the lease term of its leases based on all facts and circumstances through the effective date and did
not
elect the practical expedient pertaining to land easements as this is
not
applicable to the Company’s current contracts. The Company elected the post-transition practical expedient to
not
separate lease components from non-lease components for all leases of manufacturing equipment. The Company also elected a policy of
not
recording leases on its condensed consolidated balance sheets when the leases have a term of
12
months or less and the Company is
not
reasonably certain to elect an option to purchase the leased asset.
 
The adoption of this standard had the effect of increasing assets and liabilities on the condensed consolidated balance sheet by
$25.7
million, but did
not
have a material impact on the condensed consolidated statements of operations or cash flows.  The most significant impact relates to (
1
) the recognition of new ROU assets and lease liabilities on the balance sheet for operating leases; and (
2
) providing significant new disclosures about leasing activities.
 
Upon adoption, the Company recognized operating lease liabilities of
$33.6
million, based on the present value of the remaining minimum rental payments under current leasing standards for existing operating leases. The Company also recognized ROU assets of
$29.7
million, which represents the operating lease liability, adjusted for prepaid expenses and deferred rent. The difference between the operating lease ROU assets and lease liabilities reflects the net of advanced rent payments and deferred rent balances that were derecognized at the time of adoption.
 
Financial Instruments with "Down Round" Features
In
July 2017,
the FASB issued ASU
2017
-
11,
 
Earnings Per Share (Topic
260
); Distinguishing Liabilities from Equity (Topic
480
); Derivatives and Hedging (Topic
815
): Accounting for Certain Financial Instruments with Down Round Features
. The amendments of this ASU update the classification analysis of certain equity-linked financial instruments, or embedded features, with down round features, as well as clarify existing disclosure requirements for equity-classified instruments. When determining whether certain financial instruments should be classified as liabilities or equity instruments, a down round feature
no
longer precludes equity classification when assessing whether the instrument is indexed to an entity’s own stock. The accounting standard update became effective in the
first
quarter of fiscal year
2019,
and the Company adopted the standard using a modified retrospective approach. Since the adoption of ASU
2017
-
11
would have classified the warrants effected as equity at inception, the cumulative-effect adjustment should (i) record the issuance date value of the warrants as if they had been equity classified at the issuance date, (ii) reverse the effects of changes in the fair value of the warrants that had been recorded in the statement of operations of each period, and (iii) eliminate the derivative liabilities from the balance sheet. Upon adoption, the Company (i) recorded an increase of
$32.5
million to additional paid-in capital, (ii) recorded a decrease to accumulated deficit of
$8.5
million and (iii) decreased the warrant liability by
$41.0
million.
 
Recent Accounting Standards or Updates
Not
Yet Effective
 
Fair Value Measurement
In
August 2018,
the FASB issued ASU
2018
-
13,
Fair Value Measurement (Topic
820
): Disclosure Framework—Changes to the Disclosure Requirements for Fair Value Measurement
, which amends ASC
820,
Fair Value Measurement
. ASU
2018
-
13
modifies the disclosure requirements for fair value measurements by removing, modifying or adding certain disclosures. The accounting standard update will be effective beginning in the
first
quarter of fiscal
2020,
with removed and modified disclosures to be adopted on a retrospective basis, and new disclosures to be adopted on a prospective basis. The Company is in the initial stages of evaluating the impact of the standard on its condensed consolidated financial statements.
 
Collaborative Revenue Arrangements
In
November 2018,
the FASB issued ASU
2018
-
18,
Clarifying the Interaction between Topic
808
and Topic
606
, that clarifies the interaction between the guidance for certain collaborative arrangements and Topic
606,
the new revenue recognition standard. A collaborative arrangement is a contractual arrangement under which
two
or more parties actively participate in a joint operating activity and are exposed to significant risks and rewards that depend on the activity’s commercial success. The ASU provides guidance on how to assess whether certain transactions between collaborative arrangement participants should be accounted for within the revenue recognition standard. The accounting standard update will be effective beginning in the
first
quarter of fiscal year
2020
retroactively. The Company does
not
believe that the impact of the new standard on its condensed consolidated financial statements will be material.
 
Credit Losses
In
June 2016,
the FASB issued ASU
2016
-
13,
Financial Instruments—Credit Losses (Topic
326
), Measurement of Credit Losses on Financial Instruments
. ASU
2016
-
13
requires entities to measure all expected credit losses for most financial assets held at the reporting date based on an expected loss model which includes historical experience, current conditions, and reasonable and supportable forecasts. Entities will now use forward-looking information to better form their credit loss estimates. ASU
2016
-
13
also requires enhanced disclosures to help financial statement users better understand significant estimates and judgments used in estimating credit losses, as well as the credit quality and underwriting standards of an entity's portfolio. ASU
2016
-
13
will become effective for the Company beginning in the
first
quarter of fiscal year
2020.
The Company does
not
believe that the impact of the new standard on its condensed consolidated financial statements will be material.
 
Use of Estimates and Judgements
 
The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates, judgements and assumptions that affect the reported amounts of assets and liabilities, disclosures of contingent assets and liabilities at the date of the condensed consolidated financial statements, and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates, and such differences
may
be material to the condensed consolidated financial statements.
XML 70 R5.htm IDEA: XBRL DOCUMENT v3.19.3
Condensed Consolidated Statements of Operations (Unaudited) (Parentheticals) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Revenues, related party $ 18 $ 8,803
Product [Member]    
Revenues, related party 2 151
Licenses and Royalties [Member]    
Revenues, related party (380) 7,918
Grants and Collaborations [Member]    
Revenues, related party $ 396 $ 734
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Note 4 - Debt
3 Months Ended
Mar. 31, 2019
Notes to Financial Statements  
Debt Disclosure [Text Block]
4.
Debt
 
Net carrying amounts of debt are as follows:
 
    March 31, 2019   December 31, 2018
(In thousands)   Principal   Unamortized Debt (Discount) Premium   Change in Fair Value   Net Balance   Principal   Unamortized Debt (Discount) Premium   Change in Fair Value   Net Balance
Convertible notes payable                                                                
6% convertible notes due 2021   $
60,000
    $
    $
48
    $
60,048
    $
60,000
    $
    $
(2,082
)   $
57,918
 
2015 Rule 144A convertible notes    
37,887
     
(358
)    
     
37,529
     
37,887
     
(2,413
)    
     
35,474
 
2014 Rule 144A convertible notes    
24,004
     
(289
)    
     
23,715
     
24,004
     
(867
)    
     
23,137
 
August 2013 financing convertible note    
4,863
     
(596
)    
     
4,267
     
4,415
     
(70
)    
     
4,345
 
     
126,754
     
(1,243
)    
48
     
125,559
     
126,306
     
(3,350
)    
(2,082
)    
120,874
 
Related party convertible notes payable                                                                
2014 Rule 144A convertible notes    
24,705
     
(346
)    
     
24,359
     
24,705
     
(1,038
)    
     
23,667
 
                                                                 
Loans payable and credit facilities                                                                
GACP secured term loan facility    
36,000
     
(1,208
)    
     
34,792
     
36,000
     
(1,349
)    
     
34,651
 
Ginkgo note    
12,000
     
(3,832
)    
     
8,168
     
12,000
     
(4,047
)    
     
7,953
 
Other loans payable    
4,813
     
(1,011
)    
     
3,802
     
4,910
     
(1,047
)    
     
3,863
 
     
52,813
     
(6,051
)    
     
46,762
     
52,910
     
(6,443
)    
     
46,467
 
Related party loans payable                                                                
DSM note    
25,000
     
(5,853
)    
     
19,147
     
25,000
     
(6,311
)    
     
18,689
 
Total debt   $
229,272
    $
(13,493
)   $
48
     
215,827
    $
228,921
    $
(17,142
)   $
(2,082
)    
209,697
 
Less: current portion    
 
     
 
     
 
     
(153,752
)    
 
     
 
     
 
     
(147,677
)
Long-term debt, net of current portion    
 
     
 
     
 
    $
62,075
     
 
     
 
     
 
    $
62,020
 
 
The
6%
convertible notes due
2021
have been classified as current in the
March 
31,
2019
and
December 31, 2018
balance sheets, due to certain events subsequent to
March 31, 2019
but prior to the issuance of the
March 31, 2019
and
December 31, 2018
financial statements. See Note
12,
"Subsequent Events" for additional information.
 
On
January 14, 2019,
Wolverine Flagship Fund Trading Limited (Wolverine) agreed to waive payment of the
August 2013
Financing Convertible Note held by Wolverine at its
January 15, 2019
maturity until
July 15, 2019
in exchange for a fee, payable on or prior to
July 15, 2019,
of
$0.6
million. The Company concluded that the term extension represented a debt modification, and the fee was accounted for as additional debt discount to be amortized over the remaining term. Effective
July 15, 2019,
the due date of the waiver fee was extended to
October 13, 2019
and will bear interest at a rate of
1.75%
per month, compounded, from
July 16, 2019
to the date of payment. See Note
12,
“Subsequent Events” for additional information.
 
Future Minimum Payments
 
Future minimum payments under the Company's debt agreements as of
March 
31,
2019
are as follows:
 
(In thousands)   Convertible
Notes
  Loans
Payable
and Credit
Facilities
  Related
Party
Convertible
Notes
  Related
Party Loans
Payable and
Credit
Facilities
  Total
2019 (remaining nine months)   $
139,303
    $
9,689
    $
25,618
    $
1,875
    $
176,485
 
2020    
     
10,113
     
     
2,500
     
12,613
 
2021    
     
34,776
     
     
28,146
     
62,922
 
2022    
     
13,450
     
     
     
13,450
 
2023    
     
399
     
     
     
399
 
Thereafter    
     
2,268
     
     
     
2,268
 
Total future minimum payments    
139,303
     
70,695
     
25,618
     
32,521
     
268,137
 
Less: amount representing interest    
(12,303
)    
(17,883
)    
(913
)    
(7,521
)    
(38,620
)
Less: future conversion of accrued interest to principal    
(245
)    
     
     
     
(245
)
Present value of minimum debt payments    
126,755
     
52,812
     
24,705
     
25,000
     
229,272
 
Less: current portion of debt principal    
(126,755
)    
(4,513
)    
(24,705
)    
     
(155,973
)
Noncurrent portion of debt principal   $
    $
48,299
    $
    $
25,000
    $
73,299
 

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XML 73 R16.htm IDEA: XBRL DOCUMENT v3.19.3
Note 8 - Commitments and Contingencies
3 Months Ended
Mar. 31, 2019
Notes to Financial Statements  
Contingencies Disclosure [Text Block]
8.
Commitments and Contingencies
 
Contingencies
 
The Company has levied indirect taxes on sugarcane-based biodiesel sales that took place several years ago by Amyris Brasil Ltda. (see Note
12,
“Divestiture” in Part II, Item
8
of the
2018
Form
10
-K/A) to customers in Brazil, based on advice from external legal counsel. In the absence of definitive rulings from the Brazilian tax authorities on the appropriate indirect tax rate to be applied to such product sales, the actual indirect rate to be applied to such sales could differ from the rate the Company levied.
 
On
April 3, 2019,
a securities class action complaint was filed against Amyris and our CEO, John G. Melo, and former CFO (and current Chief Business Officer), Kathleen Valiasek, in the U.S. District Court for the Northern District of California. The complaint seeks unspecified damages on behalf of a purported class that would comprise all persons and entities that purchased or otherwise acquired our securities between
March 15, 2018
and
March 19, 2019.
The complaint alleges securities law violations based on statements and omissions made by the Company during such period. Subsequent to the filing of the securities class action complaint described above, on
June 21, 2019
and
October 1, 2019,
respectively,
two
separate purported shareholder derivative complaints were filed in the U.S. District Court for the Northern District of California (Bonner v. Doerr, et al., Case
No.
4:19
-cv-
03621
and Carlson v. Doerr, et al., Case
No.
4:19
-cv-
06230
) based on similar allegations to those made in the securities class action complaint described above. The derivative complaints name Amyris, Inc. as a nominal defendant and name a number of the Company’s current and former officers and directors as additional defendants. The lawsuits seek to recover, on the Company's behalf, unspecified damages purportedly sustained by the Company in connection with allegedly misleading statements and omissions made in connection with the Company’s securities filings. The derivative complaints also seek a series of changes to the Company’s corporate governance policies, restitution to the Company from the individual defendants, and an award of attorneys’ fees. These cases are in the initial pleadings stage. We believe the complaints lack merit, and intend to defend ourselves vigorously. Given the early stage of these proceedings, it is
not
yet possible to reliably determine any potential liability that could result from these matters.
 
The Company is subject to disputes and claims that arise or have arisen in the ordinary course of business and that have
not
resulted in legal proceedings or have
not
been fully adjudicated. Such matters that
may
arise in the ordinary course of business are subject to many uncertainties and outcomes are
not
predictable with reasonable assurance and therefore an estimate of all the reasonably possible losses cannot be determined at this time. Therefore, if
one
or more of these legal disputes or claims resulted in settlements or legal proceedings that were resolved against the Company for amounts in excess of management's expectations, the Company's consolidated financial statements for the relevant reporting period could be materially adversely affected.
 
Other Matters
 
Certain conditions
may
exist as of the date the condensed consolidated financial statements are issued, which
may
result in a loss to the Company but will only be recorded when
one
or more future events occur or fail to occur. The Company's management assesses such contingent liabilities, and such assessment inherently involves an exercise of judgement. In assessing loss contingencies related to legal proceedings that are pending against and by the Company or unasserted claims that
may
result in such proceedings, the Company's management evaluates the perceived merits of any legal proceedings or unasserted claims as well as the perceived merits of the amount of relief sought or expected to be sought.
 
If the assessment of a contingency indicates that it is probable that a material loss has been incurred and the amount of the liability can be estimated, then the estimated liability would be accrued in the Company's financial statements. If the assessment indicates that a potential material loss contingency is
not
probable but is reasonably possible, or is probable but cannot be reasonably estimated, then the nature of the contingent liability, together with an estimate of the range of possible loss if determinable and material would be disclosed. Loss contingencies considered to be remote by management are generally
not
disclosed unless they involve guarantees, in which case the guarantee would be disclosed.
XML 74 R1.htm IDEA: XBRL DOCUMENT v3.19.3
Document And Entity Information - shares
3 Months Ended
Mar. 31, 2019
Sep. 26, 2019
Document Information [Line Items]    
Entity Registrant Name AMYRIS, INC.  
Entity Central Index Key 0001365916  
Trading Symbol amrs  
Current Fiscal Year End Date --12-31  
Entity Filer Category Accelerated Filer  
Entity Current Reporting Status Yes  
Entity Emerging Growth Company false  
Entity Small Business true  
Entity Common Stock, Shares Outstanding (in shares)   103,400,207
Entity Shell Company false  
Document Type 10-Q  
Document Period End Date Mar. 31, 2019  
Document Fiscal Year Focus 2019  
Document Fiscal Period Focus Q1  
Amendment Flag false  
Title of 12(b) Security Common Stock  
XML 75 R50.htm IDEA: XBRL DOCUMENT v3.19.3
Note 5 - Mezzanine Equity - Mezzanine Equity (Details) - USD ($)
$ in Thousands
Mar. 31, 2019
Dec. 31, 2018
Mezzanine Equity $ 5,000 $ 5,000
Contingently Redeemable Common Stock [Member]    
Mezzanine Equity $ 5,000 $ 5,000
XML 76 R54.htm IDEA: XBRL DOCUMENT v3.19.3
Note 7 - Loss Per Share - Antidilutive Securities Excluded From Computation of Earnings Per Share (Details) - shares
3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Antidilutive securities (in shares) 52,988,063 44,683,172
Stock Options to Purchase Common Stock [Member]    
Antidilutive securities (in shares) 5,427,384 1,365,447
Convertible Promissory Notes [Member]    
Antidilutive securities (in shares) [1] 12,699,607 8,347,364
Period-end Common Stock Warrants [Member]    
Antidilutive securities (in shares) 26,411,761 29,759,452
Restricted Stock Units (RSUs) [Member]    
Antidilutive securities (in shares) 5,493,579 706,697
Period-end Preferred Stock [Member]    
Antidilutive securities (in shares) 2,955,732 4,504,212
[1] The potentially dilutive effect of convertible promissory notes was computed based on conversion ratios in effect as of the respective period end dates. A portion of the convertible promissory notes issued carries a provision for a reduction in conversion price under certain circumstances, which could potentially increase the dilutive shares outstanding. Another portion of the convertible promissory notes issued carries a provision for an increase in the conversion rate under certain circumstances, which could also potentially increase the dilutive shares outstanding.
XML 77 R58.htm IDEA: XBRL DOCUMENT v3.19.3
Note 9 - Revenue Recognition and Contract Assets and Liabilities - Revenue in Connection With Significant Revenue Agreement (Details) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Dec. 31, 2018
Revenues $ 14,374 $ 17,859 $ 17,859
Significant Revenue Agreement [Member]      
Revenues 6,204 12,739  
Firmenich [Member] | Significant Revenue Agreement [Member]      
Revenues 3,117 1,511  
Givaudan International, SA [Member] | Significant Revenue Agreement [Member]      
Revenues 1,575 2,576  
American Refining Group [Member] | Significant Revenue Agreement [Member]      
Revenues 1,494  
DSM International B.V. [Member] | Significant Revenue Agreement [Member]      
Revenues 18 8,652  
All Other Customers [Member]      
Revenues 8,170 5,120  
Renewable Products [Member]      
Revenues 11,884 5,195 5,195
Renewable Products [Member] | Significant Revenue Agreement [Member]      
Revenues 4,962 1,283  
Renewable Products [Member] | Firmenich [Member] | Significant Revenue Agreement [Member]      
Revenues 1,891 207  
Renewable Products [Member] | Givaudan International, SA [Member] | Significant Revenue Agreement [Member]      
Revenues 1,575 1,076  
Renewable Products [Member] | American Refining Group [Member] | Significant Revenue Agreement [Member]      
Revenues 1,494  
Renewable Products [Member] | DSM International B.V. [Member] | Significant Revenue Agreement [Member]      
Revenues 2  
Renewable Products [Member] | All Other Customers [Member]      
Revenues 6,922 3,912  
Licenses and Royalties [Member]      
Revenues 118 7,955 7,955
Licenses and Royalties [Member] | Significant Revenue Agreement [Member]      
Revenues 118 7,955  
Licenses and Royalties [Member] | Firmenich [Member] | Significant Revenue Agreement [Member]      
Revenues 498 37  
Licenses and Royalties [Member] | Givaudan International, SA [Member] | Significant Revenue Agreement [Member]      
Revenues  
Licenses and Royalties [Member] | American Refining Group [Member] | Significant Revenue Agreement [Member]      
Revenues  
Licenses and Royalties [Member] | DSM International B.V. [Member] | Significant Revenue Agreement [Member]      
Revenues (380) 7,918  
Licenses and Royalties [Member] | All Other Customers [Member]      
Revenues  
Grants and Collaborations [Member]      
Revenues 2,372 4,709 $ 4,709
Grants and Collaborations [Member] | Significant Revenue Agreement [Member]      
Revenues 1,124 3,501  
Grants and Collaborations [Member] | Firmenich [Member] | Significant Revenue Agreement [Member]      
Revenues 728 1,267  
Grants and Collaborations [Member] | Givaudan International, SA [Member] | Significant Revenue Agreement [Member]      
Revenues 1,500  
Grants and Collaborations [Member] | American Refining Group [Member] | Significant Revenue Agreement [Member]      
Revenues  
Grants and Collaborations [Member] | DSM International B.V. [Member] | Significant Revenue Agreement [Member]      
Revenues 396 734  
Grants and Collaborations [Member] | All Other Customers [Member]      
Revenues $ 1,248 $ 1,208  
XML 78 R62.htm IDEA: XBRL DOCUMENT v3.19.3
Note 10 - Related Party Transactions (Details Textual)
Mar. 31, 2019
Nikko [Member] | Aprinnova JV [Member]  
Equity Method Investment, Ownership Percentage 50.00%
XML 79 R66.htm IDEA: XBRL DOCUMENT v3.19.3
Note 11 - Stock-based Compensation - Temporal Display of Share-based Compensation, Restricted Stock and Restricted Stock Units Activity (Details) - Restricted Stock Units (RSUs) [Member] - $ / shares
3 Months Ended 12 Months Ended
Mar. 31, 2019
Dec. 31, 2018
Outstanding, RSUs (in shares) 5,294,803  
Outstanding, weighted average grant-date fair value (in dollars per share) $ 5.50  
Outstanding, weighted average remaining contractual life (Year) 1 year 182 days 1 year 255 days
Awarded (in shares) 493,790  
Awarded, weighted average grant-date fair value (in dollars per share) $ 4.65  
RSUs released (in shares) (192,795)  
RSUs released, weighted average grant-date fair value (in dollars per share) $ 6.55  
RSUs forfeited (in shares) (102,219)  
RSUs forfeited, weighted average grant-date fair value (in dollars per share) $ 5.61  
Outstanding, RSUs (in shares) 5,493,579 5,294,803
Outstanding, weighted average grant-date fair value (in dollars per share) $ 5.38 $ 5.50
Vested or expected to vest (in shares) 5,153,107  
Vested or expected to vest, weighted average grant-date fair value (in dollars per share) $ 5.39  
Vested or expected to vest, weighted average remaining contractual life (Year) 1 year 182 days  
XML 80 R49.htm IDEA: XBRL DOCUMENT v3.19.3
Note 5 - Mezzanine Equity (Details Textual) - Gates Foundation Purchase Agreement [Member] - USD ($)
$ / shares in Units, $ in Millions
Apr. 08, 2016
Mar. 31, 2019
Share Price $ 17.10  
Compound Annual Return 10.00%  
Research and Development Obligation, Remaining Amount   $ 0.6
XML 81 R45.htm IDEA: XBRL DOCUMENT v3.19.3
Note 3 - Fair Value Measurement - Reconciliation for Compound Embedded Derivative Liability (Details) - Fair Value, Inputs, Level 3 [Member]
$ in Thousands
3 Months Ended
Mar. 31, 2019
USD ($)
Fair value $ 42,796
Derecognition upon adoption of ASU 2017-11 (41,037)
Change in fair value 2,039
Fair value 3,798
Equity Securities [Member]  
Fair value 41,272
Derecognition upon adoption of ASU 2017-11 (39,513)
Change in fair value 2,039
Fair value 3,798
Debt Securities [Member]  
Fair value 1,524
Derecognition upon adoption of ASU 2017-11 (1,524)
Change in fair value
Fair value
XML 82 R41.htm IDEA: XBRL DOCUMENT v3.19.3
Note 2 - Balance Sheet Details - Other Noncurrent Liabilities (Details) - USD ($)
$ in Thousands
Mar. 31, 2019
Dec. 31, 2018
Contract termination fees, net of current portion $ 8,207 $ 7,715
Liability for unrecognized tax benefit 6,582 6,582
Contract liability, net of current portion (Note 9) 1,449 1,587
Deferred rent, net of current portion(1) 6,440
Other 682 868
Total other noncurrent liabilities $ 16,920 $ 23,192
XML 83 R20.htm IDEA: XBRL DOCUMENT v3.19.3
Note 12 - Subsequent Events
3 Months Ended
Mar. 31, 2019
Notes to Financial Statements  
Subsequent Events [Text Block]
12.
Subsequent Events
 
Cannabinoid Agreement
 
On
May 2, 2019,
the Company consummated an agreement entered into
March 18, 2019
related to a
$300
million research, collaboration and license agreement (the Cannabinoid Agreement) with LAVVAN, Inc., a newly formed investment-backed company (Lavvan), for the development, manufacture and commercialization of cannabinoids, subject to certain closing conditions noted below. Under the agreement, the Company would perform research and development activities and Lavvan would be responsible for the commercialization of the cannabinoids developed under the agreement. The Cannabinoid Agreement is being principally funded on a milestone basis, with the Company also entitled to receive certain supplementary research and development funding from Lavvan. The Company could receive aggregate funding of up to
$300
million over the term of the Cannabinoid Agreement if all of the milestones are achieved. Additionally, the agreement provides for profit share to the Company on Lavvan's gross profit margin once products are commercialized; these payments will be due for the next
20
years. The consummation of the transactions contemplated by the Cannabinoid Agreement is subject to certain conditions, including obtaining certain
third
party consents and releases and the repayment or refinancing of the
2014
Rule
144A
Convertible Notes and the
2015
Rule
144A
Convertible Notes (see Note
4,
“Debt”). On
May 2, 2019,
the parties consummated the transactions contemplated by the Cannabinoid Agreement, including the formation of a special purpose entity to hold certain intellectual property created during the collaboration (the Cannabinoid Collaboration IP), the licensing of certain Company intellectual property to Lavvan, the licensing of the Cannabinoid Collaboration IP to the Company and Lavvan, and the granting by the Company to Lavvan of a lien on the Company background intellectual property being licensed to Lavvan under the Cannabinoid Agreement, which lien would be subordinated to the lien on such intellectual property under the GACP Term Loan Facility (see Note
4,
“Debt”).
 
LSA Amendments, Assignment and Waivers
 
On
April 4, 2019,
the Company and GACP amended the LSA (see Note
4,
“Debt”) to (i) effective
December 31, 2018,
eliminate the conditions giving rise to the early maturity date, so that loans under the GACP Term Loan Facilities would have a maturity date of
July 1, 2021, (
ii) remove certain Company intellectual property related to the Cannabinoid Agreement from the lien granted by the Company to GACP under the LSA, (iii) eliminate the Company’s ability to obtain the Incremental GACP Term Loan Facility, (iv) eliminate the Company’s reinvestment rights with respect to mandatory prepayments upon asset sales, (v) restrict the Company’s ability to pay interest and principal on other indebtedness without the consent of GACP, and (vi) provide that the Company must have at all times at least
$15
million of unrestricted, unencumbered cash subject to a control agreement in favor of GACP.
 
On
April 4, 2019,
the Company and GACP entered into a waiver agreement, pursuant to which GACP agreed to waive breaches of certain covenants under the LSA occurring prior to, as of and after
December 31, 2018
through
April 8, 2019,
including covenants related to quarterly minimum revenues, minimum liquidity amounts and a minimum asset coverage ratio. In connection with such waiver, the Company agreed to pay GACP fees of
$0.8
million.
 
On
April 15, 2019,
the Company, GACP and Foris Ventures, LLC (Foris, an entity affiliated with director John Doerr of Kleiner Perkins Caufield & Byers, a current stockholder, and an owner of greater than
five
percent of the Company’s outstanding common stock) entered into a Loan Purchase Agreement, pursuant to which Foris agreed to purchase and assume from GACP, and GACP agreed to sell and assign to Foris, the outstanding loans under the LSA and all documents and assets related thereto. In connection with such purchase and assignment, the Company agreed to repay Foris
$2.5
million of the purchase price paid by Foris to GACP (the Company LPA Obligation). The closing of the loan purchase and assignment occurred on
April 16, 2019.
 
On
August 14, 2019,
the Company and Foris entered into an Amendment
No.
5
and Waiver to the LSA (the LSA Amendment and Waiver), pursuant to which (i) the maturity date of the loans under the LSA was extended from
July 1, 2021
to
July 1, 2022, (
ii) the interest rate for the loans under the LSA was modified from the sum of (A) the greater of (
x
) the prime rate as reported in the Wall Street Journal or (y) 
4.75%
plus (B) 
9%
to the greater of (A)
12%
or (B) the rate of interest payable with respect to any indebtedness of the Company, (iii) the amortization of the loans under the LSA was delayed until
December 16, 2019, (
iv) certain accrued and future interest and agency fee payments under the LSA were delayed until
December 16, 2019, (
v) certain covenants under the LSA, including related definitions, were amended to provide the Company with greater operational and financial flexibility, including, without limitation, to permit the incurrence of the indebtedness under the Naxyris Loan Facility (as described below) and the granting of liens with respect thereto, subject to the terms of an intercreditor agreement between Foris and Naxyris S.A. (Naxyris) governing the respective rights of the parties with respect to, among other things, the assets securing the Naxyris Loan Agreement and the LSA (the Intercreditor Agreement), (vi) certain outstanding unsecured promissory notes issued by the Company to Foris on
April 8, 2019,
June 11, 2019,
July 10, 2019
and
July 26, 2019 (
as described below under “Foris Credit Agreements”), in an aggregate principal amount of
$32.5
million, as well as the Company LPA Obligation, were added to the loans under the LSA, made subject to the LSA and secured by the security interest in the collateral granted to Foris under the LSA, and such promissory notes and contractual obligation were canceled in connection therewith, and (vii) Foris agreed to waive certain existing defaults under the LSA. After giving effect to the LSA Amendment and Waiver, there is
$71.0
million aggregate principal amount of loans outstanding under the LSA, subject to quarterly covenants including minimum revenues, minimum liquidity amounts and a minimum asset coverage ratio. In connection with the entry into the LSA Amendment and Waiver, on
August 14, 2019
the Company issued to Foris a warrant to purchase up to
1,438,829
shares of Common Stock at an exercise price of
$2.87
per share, with an exercise term of
two
years from issuance. Pursuant to the terms of the warrant, Foris
may
not
exercise the Foris Warrant to the extent that, after giving effect to such exercise, Foris, together with its affiliates, would beneficially own in excess of
19.99%
of the number of shares of common stock outstanding after giving effect to such exercise, unless the Company has obtained stockholder approval to exceed such limit in accordance with Nasdaq rules and regulations, which the Company intends to seek at its
2019
annual meeting of stockholders.
 
Foris Credit Agreements
 
On
April 8, 2019,
the Company and Foris entered into a credit agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of
$8.0
million (the
April
Foris Credit Agreement), which the Company borrowed in full on
April 8, 2019
and issued to Foris a promissory note in the principal amount of
$8.0
million (the
April
Foris Note). The
April
Foris Note has a maturity date of
October 14, 2019.
In connection with the entry into the
April
Foris Credit Agreement and the issuance of the
April
Foris Note, which has
no
stated interest rate, the Company agreed to pay Foris a fee of
$1.0
million, payable on or prior to the maturity date of the
April
Foris Note (the
April
Foris Note Fee); provided, that the
April
Foris Note Fee will be reduced to
$0.5
million if the Company repays the
April
Foris Note in full by
July 15, 2019.
The
April
Foris Note is subordinated in right of payment to the Tranche II Note held by Wolverine (see Note
4,
“Debt” and above in this Note
12,
“Subsequent Events”).
 
On
June 11, 2019,
the Company and Foris entered into a credit agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of
$8.5
million, which the Company borrowed in full on
June 11, 2019
and issued to Foris a promissory note in the principal amount of
$8.5
million (the
June
Foris Note). The
June
Foris Note (i) accrues interest at a rate of
12.5%
per annum from and including
June 11, 2019,
which interest is payable on the maturity date or the earlier repayment or other satisfaction of the
June
Foris Note, and (ii) matures on
August 28, 2019;
provided, that if the
May 2017
Cash Warrant held by DSM and the
August 2017
DSM Cash Warrant (see Note
6,
“Stockholders’ Deficit”) are exercised, then the maturity date of the
June
Foris Note will be the business day immediately following such exercise.
 
On
July 10, 2019,
the Company and Foris entered into a credit agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of
$16.0
million (the
July
Foris Credit Agreement), of which the Company borrowed
$8.0
million on
July 10, 2019
and
$8.0
million on
July 26, 2019
and issued to Foris promissory notes, each in the principal amount of
$8.0
million, on such dates (the
July
Foris Notes). The
July
Foris Notes (i) accrue interest at a rate of
12.5%
per annum from and including the respective date of issuance, which interest is payable on the maturity date or the earlier repayment or other satisfaction of the applicable
July
Foris Note, and (ii) mature on
December 31, 2019.
In connection with the entry into the
July
Foris Credit Agreement, the Company and Foris amended the warrant issued to Foris on
August 17, 2018 (
see Note
6,
“Stockholders’ Deficit”) to reduce the exercise price of such warrant from
$7.52
per share to
$2.87
per share.
 
The Company
may
at its option repay the amounts outstanding under the
April
Foris Note (including the
April
Foris Note Fee), the
June
Foris Note and the
July
Foris Notes before their respective maturity dates, in whole or in part, at a price equal to
100%
of the amount being repaid plus, in the case of the
June
Foris Note and the
July
Foris Notes, accrued and unpaid interest on such amount to the date of repayment.
 
On
August 14, 2019,
the
April
Foris Note, the
June
Foris Note and the
July
Foris Notes were added to the loans under the LSA, made subject to the LSA and secured by the security interest in the collateral granted to Foris under the LSA, and such notes were canceled in connection therewith. See above under “LSA Amendments, Assignment and Waivers” for additional information.
 
On
August 28, 2019,
the Company and Foris entered into a credit agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of
$19.0
million (the
August
Foris Credit Agreement), which the Company borrowed in full on
August 28, 2019
and issued to Foris a promissory note in the principal amount of
$19.0
million (the
August
Foris Note). The
August
Foris Note (i) accrues interest at a rate of
12%
per annum from and including
August 28, 2019,
which interest is payable quarterly in arrears on each
March 31,
June 30,
September 30
and
December 31,
beginning
December 31, 2019,
and (ii) matures on
January 1, 2023.
The Company
may
at its option repay the amounts outstanding under the
August
Foris Note before the maturity date, in whole or in part, at a price equal to
100%
of the amount being repaid plus accrued and unpaid interest on such amount to the date of repayment. Also, on
August 28, 2019
in connection with the entry into the
August
Foris Credit Agreement, the Company and Foris amended the warrant issued to Foris on
April 26, 2019
to reduce the exercise price of such warrant from
$5.12
per share to
$3.90
per share, and amended the warrant issued to Foris on
May 14, 2019
to reduce the exercise price of such warrant from
$4.56
per share to
$3.90
per share. See Note
6,
“Stockholders’ Deficit” for information on the original warrants.
 
In connection with the entry into the
August
Foris Credit Agreement, on
August 14, 2019
the Company issued to Foris a warrant to purchase up to
4,871,795
shares of Common Stock at an exercise price of
$3.90
per share, with an exercise term of
two
years from issuance in a private placement pursuant to the exemption from registration under Section
4
(a)(
2
) of the Securities Act of
1933,
as amended (the Securities Act), and Regulation D promulgated under the Securities Act. The exercise price of the warrant is subject to standard adjustments but does
not
contain any anti-dilution protection, and the warrants only permit “cashless” or “net” exercise after the
six
-month anniversary of issuance of the applicable warrant, and only to the extent that there is
not
an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, Foris
may
not
exercise the warrant to the extent that, after giving effect to such exercise, Foris, together with its affiliates, would beneficially own in excess of
19.99%
of the number of shares of common stock outstanding after giving effect to such exercise, unless the Company has obtained stockholder approval to exceed such limit in accordance with Nasdaq rules and regulations, which the Company intends to seek at its
2019
annual meeting of stockholders.
 
Private Placements
 
On
April 
16,
2019,
the Company sold and issued to Foris
6,732,369
shares of common stock at a price of
$2.87
per share, as well as a warrant to purchase up to
5,424,804
shares of common stock at an exercise price of
$2.87
per share, with an exercise term of
two
years from issuance, in a private placement pursuant to the exemption from registration under Section
4
(a)(
2
) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of
$20.0
million (the Foris Investment).
 
On
April 26, 2019,
the Company sold and issued (i)
2,832,440
shares of common stock at a price of
$5.12
per share, as well as a warrant to purchase up to
3,983,230
shares of common stock at an exercise price of
$5.12
per share, with an exercise term of
two
years from issuance, to Foris and (ii) an aggregate of
2,043,781
shares of common stock at a price of
$4.02
per share, as well as warrants to purchase up to an aggregate of
1,635,025
shares of common stock at an exercise price of
$5.02
per share, with an exercise term of
two
years from issuance, to certain other non-affiliated investors, in each case in private placements pursuant to the exemption from registration under Section
4
(a)(
2
) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of
$23.2
million. On
August 28, 2019,
in connection with the entry into the
August
Foris Credit Agreement (as described above under "Foris Credit Agreements"), the Company and Foris amended the warrant issued to Foris on
April 26, 2019
to reduce the exercise price of such warrant from
$5.12
per share to
$3.90
per share.
 
On
April 29, 2019,
the Company sold and issued (i)
913,529
shares of common stock at a price of
$4.76
per share, as well as a warrant to purchase up to
1,212,787
shares of common stock at an exercise price of
$4.76
per share, with an exercise term of
two
years from issuance, to Vivo and (ii) an aggregate of
323,382
shares of common stock at a price of
$4.02
per share, as well as warrants to purchase up to an aggregate of
258,704
shares of common stock at an exercise price of
$5.02
per share, with an exercise term of
two
years from issuance, to certain other non-affiliated investors, in each case in private placements pursuant to the exemption from registration under Section
4
(a)(
2
) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of
$5.8
million.
 
On
May 3, 2019,
the Company sold and issued
1,243,781
shares of common stock at a price of
$4.02
per share, as well as a warrant to purchase up to
995,024
shares of common stock at an exercise price of
$5.02
per share, with an exercise term of
two
years from issuance, to a non-affiliated investor in a private placement pursuant to the exemption from registration under Section
4
(a)(
2
) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of
$5
million.
 
The exercise price of the warrants issued in the foregoing private placements is subject to standard adjustments but does
not
contain any anti-dilution protection, and the warrants only permit “cashless” or “net” exercise after the
six
-month anniversary of issuance of the applicable warrant, and only to the extent that there is
not
an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, in connection with the foregoing private placements, the Company agreed
not
to effect any exercise or conversion of any Company security, and the investors agreed
not
to exercise or convert any portion of any Company security, to the extent that after giving effect to such exercise or conversion, the applicable investor, together with its affiliates, would beneficially own in excess of
19.99%
of the number of shares of common stock outstanding immediately after giving effect to such exercise or conversion, and the warrant contained a similar limitation.
 
DSM Agreements
 
On
April 16, 2019,
the Company assigned to DSM, and DSM assumed, all of the Company’s rights and obligations under the Value Sharing Agreement (see Note
9,
“Revenue Recognition”), for aggregate consideration to the Company of
$57.0
million,
$29.1
million of which was paid to the Company in cash, with the remaining
$27.9
million being used to pay certain existing obligations of the Company to DSM. The Company used a majority of the cash proceeds to repay a portion of the
2015
Rule
144A
Convertible Notes (see Note
4,
“Debt”).
 
In addition, on
April 16, 2019
the Company and DSM entered into amendments to the Supply Agreement and the Performance Agreement (see Note
9,
“Revenue Recognition”), as well as the Quota Purchase Agreement relating to the
December 2017
sale of Amyris Brasil to DSM (see Note
13,
“Divestiture” in Part II, Item
8
of the
2018
Form
10
-K/A), pursuant to which (i) DSM agreed to reduce certain manufacturing costs and fees paid by the Company related to the production of farnesene under the Supply Agreement through
2021,
as well as remove the priority of certain customers over the Company with respect to production capacity at the Brotas, Brazil facility, (ii) the Company agreed to provide DSM rights to conduct certain process and downstream recovery improvements under the Performance Agreement at facilities other than the Brotas, Brazil facility in exchange for DSM providing the Company with a license to such improvements and (iii) the Company released DSM from its obligation to provide manufacturing and support services under the Quota Purchase Agreement in connection with the Company’s planned new manufacturing facility, which is
no
longer planned to be located at the Brotas, Brazil location.
 
On
September 17, 2019,
the Company and DSM entered into a credit agreement (the
“2019
DSM Credit Agreement”) to make available to the Company a secured credit facility in an aggregate principal amount of
$8.0
million, to be issued in separate installments of
$3.0
million,
$3.0
million and
$2.0
million, respectively, with each installment being subject to certain closing conditions, including the payment of certain existing obligations of the Company to DSM. On
September 17, 2019,
the Company borrowed the
first
installment of
$3.0
million under the
2019
DSM Credit Agreement, all of which proceeds were used to pay certain existing obligations of the Company to DSM, and issued to DSM a promissory note in the principal amount of
$3.0
million. On
September 19, 2019,
the Company borrowed the
second
installment of
$3.0
million under the
2019
DSM Credit Agreement, all of which proceeds were used to pay certain existing obligations of the Company to DSM, and issued to DSM a promissory note in the principal amount of
$3.0
million. On
September 23, 2019,
the Company borrowed the final installment of
$2.0
million under the
2019
DSM Credit Agreement,
$1.5
million of which proceeds were used to pay certain existing obligations of the Company to DSM, and issued to DSM a promissory note in the principal amount of
$2.0
million. The promissory notes issued under the
2019
DSM Credit Agreement (i) mature on
August 7, 2022, (
ii) accrue interest at a rate of
12.5%
per annum from and including the applicable date of issuance, which interest is payable quarterly in arrears on each
January 1,
April 1,
July 1
and
October 1,
beginning
January 1, 2020,
and (iii) are secured by a
first
-priority lien on certain Company intellectual property licensed to DSM. The Company
may
at its option repay the amounts outstanding under the
2019
DSM Credit Agreement before the maturity date, in whole or in part, at a price equal to
100%
of the amount being repaid plus accrued and unpaid interest on such amount to the date of repayment. In addition, the Company is required to repay the amounts outstanding under the
2019
DSM Credit Agreement (i) in an amount equal to the gross cash proceeds, if any, received by the Company upon the exercise by DSM of any of the common stock purchase warrants issued by the Company to DSM on
May 11, 2017
or
August 7, 2017 (
see Note
7,
“Stockholders’ Deficit”) and (ii) in full upon the request of DSM at any time following the receipt by the Company of at least
$50.0
million of gross cash proceeds from
one
or more sales of equity securities of the Company on or prior to
June 30, 2020.
 
Raizen Joint Venture Agreement
 
On
May 10, 2019,
the Company and Raizen Energia S.A. (Raizen) entered into a joint venture agreement relating to the formation and operation of a joint venture relating to the production, sale and commercialization of alternative sweetener products. In connection with the formation of the joint venture, among other things, (i) the joint venture will construct a manufacturing facility on land owned by Raizen and leased to the joint venture (the Sweetener Plant), (ii) the Company will grant to the joint venture an exclusive, royalty-free, worldwide, license to certain technology owned by the Company relevant to the joint venture’s business, and (iii) the Company and Raizen will enter into a shareholders agreement setting forth the rights and obligations of the parties with respect to, and the management of, the joint venture. The formation of the joint venture is subject to certain conditions, including certain regulatory approvals and the achievement of certain technological and economic milestones relating to the Company’s existing production of its alternative sweetener product. If such conditions are
not
satisfied by
December 31, 2019,
the joint venture will automatically terminate. In addition, notwithstanding the satisfaction of the closing conditions, Raizen
may
elect
not
to consummate the formation and operation of the joint venture, in which event, the Company will retain the right to construct and operate the Sweetener Plant.
 
Upon the closing of the joint venture, each party will make an initial capital contribution to the joint venture of
2,500,000
Brazilian Real (
R$2,500,000
) and the joint venture will be owned
50%
by the Company and
50%
by Raizen. Within
60
days of the formation, the parties will make an aggregate cash contribution to the joint venture of
U.S.$9,000,000
to purchase certain fixed assets currently owned by the Company and located at the site of the Company’s former joint venture with Sao Martinho S.A. in Pradopolis, Brazil for
U.S.$3,000,000.
In addition, within
six
months of the formation, the Company will contribute to the joint venture its existing supply agreements related to its alternative sweetener product, subject to certain exceptions, in exchange for shares of dividend-bearing preferred stock in the joint venture, which will be entitled, for a period of
10
years commencing from the initial date of operation of the Sweetener Plant, to certain priority fixed cumulative dividends including, in the event that certain technological and economic milestones are met in any fiscal quarter, a percentage of the operating cash flow of the joint venture in such quarter.
 
After the formation of the joint venture, the parties will
not
conduct activities similar or identical to the joint venture. In the event that certain technological and economic milestones are
not
met in any fiscal year beginning with the
third
fiscal year after formation of the joint venture and ending with the
seventh
fiscal year after formation of the joint venture, Raizen shall have the right to sell all of its shares in the joint venture to the Company at a price per share equal to the higher of the book value and the amount of Raizen’s investments in the joint venture, as adjusted for Raizen’s cost of capital.
 
2015
and
2014
Rule
144A
Convertible Notes Exchanges
 
On
April 16, 2019,
the Company repaid in cash the
$37.9
million outstanding balance under the
2015
Rule
144A
Convertible Notes.
 
On
May 10, 2019,
the Company exchanged
$13.5
million aggregate principal amount of the
2014
Rule
144A
Convertible Notes (see Note
4,
“Debt”) held by certain non-affiliated investors, including accrued and unpaid interest thereon up to, but excluding,
May 15, 2019,
for an aggregate of
3,479,008
shares of common stock and warrants to purchase an aggregate of
1,391,603
shares of common stock at an exercise price of
$5.02
per share, with an exercise term of
two
years from issuance, in a private exchange pursuant to the exemption from registration under Section
3
(a)(
9
) of the Securities Act.
 
On
May 14, 2019,
the Company exchanged
$5.0
million aggregate principal amount of the
2014
Rule
144A
Convertible Notes held by Foris, including accrued and unpaid interest thereon up to, but excluding,
May 15, 2019,
for
1,122,460
shares of common stock and a warrant to purchase up to
352,638
shares of common stock at an exercise price of
$4.56
per share, with an exercise term of
two
years from issuance, in a private exchange pursuant to the exemption from registration under Section
3
(a)(
9
) of the Securities Act. On
August 28, 2019,
in connection with the entry into the
August
Foris Credit Agreement (as described above under "Foris Credit Agreements"), the Company and Foris amended the warrant issued to Foris on
May 14, 2019
to reduce the exercise price of such warrant from
$4.56
per share to
$3.90
per share.
 
On
May 15, 2019,
the Company exchanged
$10.0
million aggregate principal amount of the
2014
Rule
144A
Convertible Notes held by Maxwell (Mauritius) Pte Ltd for
2,500,000
shares of common stock in a private exchange pursuant to the exemption from registration under Section
3
(a)(
9
) of the Securities Act.
 
On
May 15, 2019,
the Company exchanged
$9.7
million aggregate principal amount of the
2014
Rule
144A
Convertible Notes held by Total for a new senior convertible note with an equal principal amount and with substantially identical terms, except that the new note had a maturity date of
June 14, 2019,
in a private exchange pursuant to the exemption from registration under Section
3
(a)(
9
) of the Securities Act. Effective
June 14, 2019,
the Company and Total agreed to extend the maturity date of the new note from
June 14, 2019
to
July 18, 2019.
Effective
July 18, 2019,
the Company and Total agreed to (i) further extend the maturity date of the new note from
July 18, 2019
to
August 28, 2019
and (ii) increase the interest rate on the new note to
10.50%
per annum, beginning
July 18, 2019.
 
The exercise price of the warrants issued in the foregoing exchanges is subject to standard adjustments but does
not
contain any anti-dilution protection, and the warrants only permit “cashless” or “net” exercise after the
six
-month anniversary of the exercisability of the applicable warrant, and only to the extent that there is
not
an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, (i) the exercisability of the warrant issued to Foris is subject to stockholder approval in accordance with Nasdaq rules and regulations, which the Company intends to seek at its
2019
annual meeting of stockholders, and (ii) each warrant provides that the Company
may
not
effect any exercise of such warrant to the extent that, after giving effect to such exercise, the applicable holder, together with its affiliates, would beneficially own in excess of
4.99%
of the number of shares of common stock outstanding after giving effect to such exercise.
 
6%
Convertible Notes due
2021
Exchanges
 
On
May 15, 2019
and
June 24, 2019,
the Company exchanged
$53.3
million and
$4.7
million principal amount, respectively, of the
6%
Convertible Notes due
2021
(see Note
4,
“Debt”), including accrued and unpaid interest thereon, representing all then-outstanding
6%
Convertible Notes due
2021,
for new senior convertible notes with an equal principal amount and warrants to purchase up to
2,000,000
and
181,818
shares of common stock, respectively, at an exercise price of
$5.12
per share, with an exercise term of
two
years from issuance, in private exchanges pursuant to the exemption from registration under Section
3
(a)(
9
) of the Securities Act. The new notes have substantially identical terms as the
6%
Convertible Notes due
2021
being exchanged, except that (i) the holders agreed to waive, until
July 22, 2019,
certain covenants relating to the effectiveness of the registration statement covering the shares of common stock issuable upon conversion of, or otherwise pursuant to, the new notes and the filing by the Company of reports with the SEC and (ii) during the period from
July 22, 2019
to
July 29, 2019,
inclusive, the holders have the right to require the Company to redeem the new notes, in whole or in part, at a price equal to
125%
of the principal amount being redeemed. The exercise price of the warrants is subject to standard adjustments but does
not
contain any anti-dilution protection, and the warrants only permit “cashless” or “net” exercise after the
six
-month anniversary of issuance, and only to the extent that there is
not
an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, the holders
may
not
exercise the warrants, and the Company
may
not
affect any exercise of the warrants, to the extent that, after giving effect to such exercise, the applicable holder, together with its affiliates, would beneficially own in excess of
4.99%
of the number of shares of common stock outstanding after giving effect to such exercise.
 
On
July 24, 2019,
Company further exchanged
$53.3
million principal amount of the previously-exchanged
6%
Convertible Senior Notes due
2021
as well as the warrant to purchase up to
2,000,000
shares of common stock issued on
May 15, 2019,
for a new senior convertible note with a principal amount of
$68.3
million (the Second Exchange Note) and a new warrant to purchase up to
2,000,000
shares of common stock at an exercise price of
$2.87
per share, with an exercise term of
two
years from
May 15, 2019 (
the Second Exchange Warrant) in a private exchange pursuant to the exemption from registration under Section
3
(a)(
9
) of the Securities Act. The Second Exchange Note and Second Exchange Warrant have substantially similar terms as the note and warrant, respectively, issued on
May 15, 2019,
except that (i) the principal amount of the Second Exchange Note would be
$68.3
million, reflecting accrued and unpaid interest and late charges under the exchanged note and a
25%
premium accruing as a result of the Company’s failure to make an installment payment on the exchanged note due
July 1, 2019
in the amount of
$6.4
million, provided that upon an event of default under the Second Exchange Note, the Company would
not
be required to redeem the Second Exchange Note in cash at a price greater than the intrinsic value of the shares of common stock underlying the Second Exchange Note, (ii) the Second Exchange Note bears interest at a rate of
18%
per annum, (iii) the holder agreed to extend its waiver of certain covenant breaches relating to the failure by the Company to timely file periodic reports with the SEC from
July 22, 2019
to
September 16, 2019, (
iv) the
first
installment date under the Second Exchange Note will occur on
October 1, 2019, (
v) the Company is required to (A) make principal payments on the Second Exchange Note in the amount of
$3.2
million on each of
August 2, 2019
and
August 22, 2019,
and (B) pay all remaining amounts then outstanding under the Second Exchange Note on
September 16, 2019,
and if the Company fails to make any such payment on the applicable payment date, the conversion price of the Second Exchange Note will be reset to the volume-weighted average price of the common stock on the trading day immediately following the Company’s filing of a Current Report on Form
8
-K with respect to its failure to make the payment due on
September 16, 2019,
if such volume-weighted average price is lower than the conversion price of the Second Exchange Note then in effect, subject to a price floor and (vi) the Second Exchange Warrant has an exercise price of
$2.87
per share.
 
On
July 26, 2019,
one
of the holders of the senior convertibles notes issued in exchange for the
6%
Convertible Notes due
2021,
holding a senior convertible note in the principal amount of
$4.7
million issued on
June 24, 2019,
exercised its right to require the Company to redeem such note in whole at a price equal to
125%
of the principal amount being redeemed, plus accrued and unpaid interest on such note to the date of repayment. Redemption of such note was initially due on
July 30, 2019
and subsequently extended to
August 30, 2019.
The Company redeemed such note in full on
August 30, 2019.
 
On
September 16, 2019,
the Company failed to pay an aggregate of
$63.6
million of outstanding principal and accrued interest on the Second Exchange Note when due. The failure resulted in an event of default under the Second Exchange Note and also triggered cross-defaults under other debt instruments of the Company which permitted the holders of such indebtedness to accelerate the amounts owing under such instruments. The Company subsequently received waivers from substantially all holders of such other debt instruments to waive the right to accelerate. As a result, the indebtedness with respect to which the Company has obtained such waivers continues to be classified as long-term on the Company’s balance sheet.  The indebtedness reflected by the Second Exchange Note continues to be classified as a current liability on the Company’s balance sheet. In addition, as a result of the payment default, the conversion price of the Second Exchange Note is subject to adjustment in accordance with the terms of the Second Exchange Note.
 
The Company does
not
currently have sufficient funds to repay the amounts outstanding under the Second Exchange Note. To date, negotiations with the holder of the Second Exchange Note have
not
been successful, and there can be
no
assurance that a favorable outcome for the Company will be reached. The Company has executed a term sheet with an existing investor for a term loan, the proceeds of which would be used to repay a portion of the Second Exchange Note. However, there can be
no
assurance that the Company will be able to obtain such financing on its expected timeline, or on acceptable terms, if at all. Even if the Company does obtain such financing, it will
not
have sufficient funds to repay the Second Exchange Note in full without obtaining additional financing, which the Company is attempting to source. The condensed consolidated financial statements do
not
include any adjustments that might result from the outcome of this uncertainty.
 
Exchange of
August 2013
Financing Convertible Note
 
On
July 8, 2019,
the
August 2013
Financing Convertible Note held by Wolverine (see Note
4,
“Debt”) was exchanged for
1,767,632
shares of common stock and a warrant to purchase
1,080,000
shares of common stock in a private exchange pursuant to the exemption from registration under Section
3
(a)(
9
) of the Securities Act. The exercise price of the warrant is subject to standard adjustments but does
not
contain any anti-dilution protection, and the warrant only permits “cashless” or “net” exercise after the
six
-month anniversary of issuance, and only to the extent that there is
not
an effective registration statement covering the resale of the shares of common stock underlying the warrant. In addition, Wolverine
may
not
exercise the warrant to the extent that, after giving effect to such exercise, Wolverine, together with its affiliates, would beneficially own in excess of
4.99%
of the number of shares of common stock outstanding after giving effect to such exercise.
 
Nikko Loan Agreement
 
On
July 29, 2019,
the Company and Nikko Chemicals Co., Ltd. (Nikko) entered into a loan agreement (the Nikko Loan Agreement) to make available to the Company secured loans in an aggregate principal amount of
$5.0
million, to be issued in separate installments of
$3.0
million and
$2.0
million, respectively, with each installment being subject to certain closing conditions, including the entry into certain commercial agreements and other arrangements relating to the Aprinnova JV (see Note
10,
“Related Party Transactions”). On
July 30, 2019,
the Company borrowed the
first
installment of
$3.0
million under the Nikko Loan Agreement and received net cash proceeds of
$2.8
million, with the remaining
$0.2
million being withheld by Nikko as prepayment of the interest payable on such loan through the maturity date. On
August 8, 2019,
the Company borrowed the remaining
$2.0
million available under the Nikko Loan Agreement and received net cash proceeds of
$1.9
million, with the remaining
$0.1
million being withheld by Nikko as prepayment of the interest payable on such loan through the maturity date. The loans (i) mature on
December 18, 2020, (
ii) accrue interest at a rate of
5%
per annum from and including the applicable loan date through the maturity date, which interest is required to be prepaid in full on the date of the applicable loan, and (iii) are secured by a
first
-priority lien on
12.8%
of the Aprinnova JV interests owned by the Company.
 
Aprinnova Working Capital Loan
 
Effective
July 31, 2019,
the Company and Nikko agreed to extend the term of the Second Aprinnova Note (see Note
5,
“Debt” in the
2018
Form
10
-K/A) from
August 1, 2019
to
August 1, 2020.
 
Naxyris Loan and Security Agreement
 
On 
August 14, 2019,
the Company, certain of the Company’s subsidiaries (the Subsidiary Guarantors) and, as lender, Naxyris, an existing stockholder of the Company and an investment vehicle owned by Naxos Capital Partners SCA Sicar, which is affiliated with NAXOS S.A.R.L. (Switzerland), for which director Carole Piwnica serves as director, entered into a Loan and Security Agreement (the Naxyris Loan Agreement) to make available to the Company a secured term loan facility in an aggregate principal amount of up to 
$10,435,000
 (the Naxyris Loan Facility), which the Company borrowed in full on
August 14, 2019.
 
Loans under the Naxyris Loan Facility have a maturity date of
July 1, 2022
and accrue interest at a rate per annum equal to the greater of (i)
12%
or (ii) the rate of interest payable with respect to any indebtedness of the Company plus
25
basis points, which interest will be payable monthly in arrears, provided that all interest accruing from and after
August 14, 2019
through
December 1, 2019
shall be due and payable on
December 15, 2019.
 
The obligations of the Company under the Naxyris Loan Facility are (i) guaranteed by the Subsidiary Guarantors and (ii) secured by a perfected security interest in substantially all of the assets of the Company and the Subsidiary Guarantors (the Collateral), junior in payment priority to Foris Ventures subject to certain limitations and exceptions, as well as the terms of the Intercreditor Agreement (as defined above).
 
Mandatory prepayments of the outstanding amounts under the Naxyris Loan Facility will be required upon the occurrence of certain events, including asset sales, a change in control, and the incurrence of additional indebtedness, subject to certain exceptions and reinvestment rights. Outstanding amounts under the Naxyris Loan Facility must also be prepaid to the extent that the borrowing base exceeds the outstanding principal amount of the loans under the Naxyris Loan Facility. In addition, the Company
may
at its option prepay the outstanding principal amount of the loans under the Naxyris Loan Facility in full before the maturity date. Any prepayment of the loans under the Naxyris Loan Facility prior to the maturity date, whether pursuant to a mandatory or optional prepayment, is subject to a prepayment charge equal to
one
year’s interest at the then-current interest rate for the Naxyris Loan Facility. Upon the repayment of the loans under the Naxyris loan facility, whether on the maturity date or earlier pursuant to an optional or mandatory prepayment, the Company will pay Naxyris an end of term fee. In addition, (i) the Company will be required to pay a fee equal to
6%
of any amount the Company fails to pay within
three
business days of its due date and (ii) any interest that is
not
paid when due will be added to principal and will bear compound interest at the applicable rate.
 
The affirmative and negative covenants in the Naxyris Loan Agreement relate to, among other items: (i) payment of taxes; (ii) financial reporting; (iii) maintenance of insurance; and (iv) limitations on indebtedness, liens, mergers, consolidations and acquisitions, transfers of assets, dividends and other distributions in respect of capital stock, investments, loans and advances, and corporate changes. The Naxyris Loan Agreement also contains financial covenants, including covenants related to minimum revenue, liquidity, and asset coverage.
 
September 2019
Credit Agreements
 
On
September 10, 2019,
the Company entered into separate credit agreements (the “Investor Credit Agreements”) with each of Schottenfeld Opportunities Fund II, L.P., Phase Five Partners, LP and Koyote Trading, LLC (the “Investors”) to make available to the Company unsecured credit facilities in an aggregate principal amount of
$12.5
million, which the Company borrowed in full on
September 10, 2019
and issued to the Investors separate promissory notes in the aggregate principal amount of
$12.5
million (the “Investor Notes”). Each Investor Note (i) accrues interest at a rate of
12%
per annum from and including
September 10, 2019,
which interest is payable quarterly in arrears on each
March 31,
June 30,
September 30
and
December 31,
beginning
December 31, 2019,
and (ii) matures on
January 1, 2023.
The Company
may
at its option repay the amounts outstanding under the Investor Notes before the maturity date, in whole or in part, at a price equal to
100%
of the amount being repaid plus accrued and unpaid interest on such amount to the date of repayment.
 
In connection with the entry into the Investor Credit Agreements, on
September 10, 2019,
the Company issued to the Investors warrants to purchase up to an aggregate of
3,205,128
shares of Common Stock at an exercise price of
$3.90
per share, with an exercise term of
two
years from issuance in a private placement pursuant to the exemption from registration under Section
4
(a)(
2
) of the Securities Act and Regulation D promulgated under the Securities Act. The exercise price of the warrants is subject to standard adjustments but does
not
contain any anti-dilution protection, and the warrants only permit “cashless” or “net” exercise after the
six
-month anniversary of issuance of the applicable warrant, and only to the extent that there is
not
an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition,
no
Investor
may
exercise its warrant to the extent that, after giving effect to such exercise, such Investor, together with its affiliates, would beneficially own in excess of
9.99%
of the number of shares of common stock outstanding after giving effect to such exercise. In addition, the Company agreed to file a registration statement providing for the resale by the Investors of the shares of Common Stock underlying the warrants with the SEC within
60
days following the date of the issuance of the warrants and to use commercially reasonable efforts to (i) cause such registration statement to become effective within
120
days following the date of the issuance of the warrants and (ii) keep such registration statement effective until the Investors
no
longer beneficially own any such shares of Common Stock or such shares of Common Stock are eligible for resale under Rule
144
under the Securities Act without regard to volume limitations. If the Company fails to file the registration statement by the filing deadline or the registration statement is
not
declared effective by the effectiveness deadline, or the Company fails to maintain the effectiveness of the registration statement as required by the warrants, then the exercise price of the warrants will be reduced by
10%,
and by an additional
5%
if such failure continues for longer than
90
days, subject to an exercise price floor of
$3.31
per share, provided that upon the cure by the Company of such failure, the exercise price of the warrants will revert to
$3.90
per share.
 
In connection with the entry into the Investor Credit Agreements and the issuance of the warrants, on
September 10, 2019,
the Company and the Investors entered into a Standstill Agreement (the “Investor Standstill Agreement”), pursuant to which the Investors agreed that, until the earliest to occur of (i) the Investors
no
longer beneficially owning any shares underlying the warrants, (ii) the Company entering into a definitive agreement involving the direct or indirect acquisition of all or a majority of the Company’s equity securities or all or substantially all of the Company’s assets or (iii) a person or group, with the prior approval of the Company’s Board of Directors (the “Board”), commencing a tender offer for all or a majority of the Company's equity securities, neither the Investors nor any of their respective affiliates will (without the prior written consent of the Board), among other things, (i) acquire any loans, debt securities, equity securities, or assets of the Company or any of its subsidiaries, or rights or options with respect thereto, except that the Investors shall be permitted to (a) purchase the shares underlying the warrants pursuant to the exercise of the warrants and (b) acquire beneficial ownership of up to
6.99%
of the Common Stock, or (ii) make any proposal, public announcement, solicitation or offer with respect to, or otherwise solicit, seek or offer to effect, or instigate, encourage, or assist any
third
party with respect to: (a) any business combination, merger, tender offer, exchange offer, or similar transaction involving the Company or any of its subsidiaries; (b) any restructuring, recapitalization, liquidation, or similar transaction involving the Company or any of its subsidiaries; (c) any acquisition of any of the Company’s loans, debt securities, equity securities or assets, or rights or options with respect thereto; or (d) any proposal to seek representation on the Board or otherwise seek to control or influence the management, Board, or policies of the Company, in each case subject to certain exceptions.
 
Ginkgo Note Amendment
 
On
September 29, 2019,
in connection with Ginkgo granting certain waivers under the
November 2017
Ginkgo Note and the Ginkgo Partnership Agreement (see Note
5,
“Debt” and Note
10,
"Revenue Recognition" in Part II, Item
8
of the
2018
Form
10
-K/A), (i) the Company and Ginkgo amended the
November 2017
Ginkgo Note to increase the interest rate from
10.5%
per annum to
12%
per annum, beginning
October 1, 2019
and (ii) the Company agreed to pay Ginkgo a cash waiver fee of
$1.3
million, payable in installments on
December 15, 2019
and
March 31, 2020.
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Note 4 - Debt (Tables)
3 Months Ended
Mar. 31, 2019
Notes Tables  
Schedule of Debt [Table Text Block]
    March 31, 2019   December 31, 2018
(In thousands)   Principal   Unamortized Debt (Discount) Premium   Change in Fair Value   Net Balance   Principal   Unamortized Debt (Discount) Premium   Change in Fair Value   Net Balance
Convertible notes payable                                                                
6% convertible notes due 2021   $
60,000
    $
    $
48
    $
60,048
    $
60,000
    $
    $
(2,082
)   $
57,918
 
2015 Rule 144A convertible notes    
37,887
     
(358
)    
     
37,529
     
37,887
     
(2,413
)    
     
35,474
 
2014 Rule 144A convertible notes    
24,004
     
(289
)    
     
23,715
     
24,004
     
(867
)    
     
23,137
 
August 2013 financing convertible note    
4,863
     
(596
)    
     
4,267
     
4,415
     
(70
)    
     
4,345
 
     
126,754
     
(1,243
)    
48
     
125,559
     
126,306
     
(3,350
)    
(2,082
)    
120,874
 
Related party convertible notes payable                                                                
2014 Rule 144A convertible notes    
24,705
     
(346
)    
     
24,359
     
24,705
     
(1,038
)    
     
23,667
 
                                                                 
Loans payable and credit facilities                                                                
GACP secured term loan facility    
36,000
     
(1,208
)    
     
34,792
     
36,000
     
(1,349
)    
     
34,651
 
Ginkgo note    
12,000
     
(3,832
)    
     
8,168
     
12,000
     
(4,047
)    
     
7,953
 
Other loans payable    
4,813
     
(1,011
)    
     
3,802
     
4,910
     
(1,047
)    
     
3,863
 
     
52,813
     
(6,051
)    
     
46,762
     
52,910
     
(6,443
)    
     
46,467
 
Related party loans payable                                                                
DSM note    
25,000
     
(5,853
)    
     
19,147
     
25,000
     
(6,311
)    
     
18,689
 
Total debt   $
229,272
    $
(13,493
)   $
48
     
215,827
    $
228,921
    $
(17,142
)   $
(2,082
)    
209,697
 
Less: current portion    
 
     
 
     
 
     
(153,752
)    
 
     
 
     
 
     
(147,677
)
Long-term debt, net of current portion    
 
     
 
     
 
    $
62,075
     
 
     
 
     
 
    $
62,020
 
Schedule of Long-term Debt Instruments [Table Text Block]
(In thousands)   Convertible
Notes
  Loans
Payable
and Credit
Facilities
  Related
Party
Convertible
Notes
  Related
Party Loans
Payable and
Credit
Facilities
  Total
2019 (remaining nine months)   $
139,303
    $
9,689
    $
25,618
    $
1,875
    $
176,485
 
2020    
     
10,113
     
     
2,500
     
12,613
 
2021    
     
34,776
     
     
28,146
     
62,922
 
2022    
     
13,450
     
     
     
13,450
 
2023    
     
399
     
     
     
399
 
Thereafter    
     
2,268
     
     
     
2,268
 
Total future minimum payments    
139,303
     
70,695
     
25,618
     
32,521
     
268,137
 
Less: amount representing interest    
(12,303
)    
(17,883
)    
(913
)    
(7,521
)    
(38,620
)
Less: future conversion of accrued interest to principal    
(245
)    
     
     
     
(245
)
Present value of minimum debt payments    
126,755
     
52,812
     
24,705
     
25,000
     
229,272
 
Less: current portion of debt principal    
(126,755
)    
(4,513
)    
(24,705
)    
     
(155,973
)
Noncurrent portion of debt principal   $
    $
48,299
    $
    $
25,000
    $
73,299
 
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Note 9 - Revenue Recognition and Contract Assets and Liabilities (Tables)
3 Months Ended
Mar. 31, 2019
Notes Tables  
Disaggregation of Revenue [Table Text Block]
    Three Months Ended March 31,
(In thousands)
  2019   2018
    Renewable Products   Licenses and Royalties   Grants and Collaborations   Total   Renewable Products   Licenses and Royalties   Grants and Collaborations   Total
United States   $
7,073
    $
    $
493
    $
7,566
    $
1,962
    $
    $
1,209
    $
3,171
 
Europe    
2,854
     
118
     
1,629
     
4,601
     
2,434
     
7,955
     
3,500
     
13,889
 
Asia    
1,718
     
     
250
     
1,968
     
678
     
     
     
678
 
South America    
220
     
     
     
220
     
21
     
     
     
21
 
Other    
19
     
     
     
19
     
100
     
     
     
100
 
    $
11,884
    $
118
    $
2,372
    $
14,374
    $
5,195
    $
7,955
    $
4,709
    $
17,859
 
Revenue in Connection with Significant Revenue Agreement [Table Text Block]
    Three Months Ended March 31,
(In thousands)
  2019   2018
    Renewable Products   Licenses and Royalties   Grants and Collaborations   Total   Renewable Products   Licenses and Royalties   Grants and Collaborations   Total
Firmenich   $
1,891
    $
498
    $
728
    $
3,117
    $
207
    $
37
    $
1,267
    $
1,511
 
Givaudan    
1,575
     
     
     
1,575
     
1,076
     
     
1,500
     
2,576
 
American Sugar Refining    
1,494
     
     
     
1,494
     
     
     
     
 
DSM - related party    
2
     
(380
)    
396
     
18
     
     
7,918
     
734
     
8,652
 
Subtotal revenue from significant revenue agreements    
4,962
     
118
     
1,124
     
6,204
     
1,283
     
7,955
     
3,501
     
12,739
 
Revenue from all other customers    
6,922
     
     
1,248
     
8,170
     
3,912
     
     
1,208
     
5,120
 
Total revenue from all customers   $
11,884
    $
118
    $
2,372
    $
14,374
    $
5,195
    $
7,955
    $
4,709
    $
17,859
 
Contract with Customer, Asset and Liability [Table Text Block]
(In thousands)
  March 31, 2019   December 31, 2018
Accounts receivable, net   $
10,968
    $
16,003
 
Accounts receivable - related party, net   $
1,334
    $
1,349
 
Accounts receivable, unbilled - related party   $
    $
8,021
 
Accounts receivable, unbilled, noncurrent - related party   $
1,203
    $
1,203
 
Contract liabilities   $
8,333
    $
8,236
 
Contract liabilities, noncurrent
(1)
  $
1,449
    $
1,587
 
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Table Text Block]
(In thousands)   As of March 31, 2019
Remaining 2019   $
23,920
 
2020    
38,508
 
2021    
31,172
 
2022 and thereafter    
 
Total from all customers   $
93,600