0001171843-19-006372.txt : 20191004 0001171843-19-006372.hdr.sgml : 20191004 20191004164401 ACCESSION NUMBER: 0001171843-19-006372 CONFORMED SUBMISSION TYPE: 10-K/A PUBLIC DOCUMENT COUNT: 119 CONFORMED PERIOD OF REPORT: 20181231 FILED AS OF DATE: 20191004 DATE AS OF CHANGE: 20191004 FILER: COMPANY DATA: COMPANY CONFORMED NAME: AMYRIS, INC. CENTRAL INDEX KEY: 0001365916 STANDARD INDUSTRIAL CLASSIFICATION: INDUSTRIAL ORGANIC CHEMICALS [2860] IRS NUMBER: 550856151 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 10-K/A SEC ACT: 1934 Act SEC FILE NUMBER: 001-34885 FILM NUMBER: 191138985 BUSINESS ADDRESS: STREET 1: 5885 HOLLIS STREET, SUITE 100 CITY: EMERYVILLE STATE: CA ZIP: 94608 BUSINESS PHONE: 510-450-0761 MAIL ADDRESS: STREET 1: 5885 HOLLIS STREET, SUITE 100 CITY: EMERYVILLE STATE: CA ZIP: 94608 FORMER COMPANY: FORMER CONFORMED NAME: AMYRIS BIOTECHNOLOGIES INC DATE OF NAME CHANGE: 20060613 10-K/A 1 f10ka_100119p.htm FORM 10-K/A

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

____________________________________________________

FORM 10-K/A

Amendment No. 1

(Mark One)

 

x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
  For the fiscal year ended December 31, 2018

OR

 

  TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
  For the transition period from ____ to ____

 

Commission File Number: 001-34885

____________________________________________________

AMYRIS, INC.

(Exact name of registrant as specified in its charter)

 

Delaware   55-0856151
(State or other jurisdiction of incorporation or organization)   (I.R.S. Employer Identification No.)

 

5885 Hollis Street, Suite 100, Emeryville, California 94608

(Address of principal executive offices and Zip Code)

 

(510) 450-0761

(Registrant’s telephone number, including area code)

 

Securities registered pursuant to Section 12(b) of the Act:

 

Title of each class Trading symbol(s) Name of each exchange on which registered
Common Stock, $0.0001 par value per share AMRS Nasdaq Global Select Market

  

Securities registered pursuant to Section 12(g) of the Act:

None

 

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.   Yes    No 

 

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act.  Yes    No 

 

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.    Yes   No 

 

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).    Yes    No 

 

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See definitions of “large accelerated filer”, “accelerated filer”, “smaller reporting company”, and “emerging growth company” in Rule 12b-2 of the Exchange Act.

 

Large accelerated filer Accelerated filer Non-accelerated filer Smaller reporting company Emerging growth company

 

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.

 

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).    Yes    No 

 

 

 

 

The aggregate market value of the registrant’s common stock held by non-affiliates of the registrant as of June 28, 2019, the last business day of the registrant's most recently completed second fiscal quarter, was $226.5 million based upon the closing price of the registrant’s common stock reported for such date on the Nasdaq Global Select Market.

 

Number of shares of the registrant’s common stock outstanding as of September 26, 2019: 103,400,207

 

 

DOCUMENTS INCORPORATED BY REFERENCE

None.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

EXPLANATORY NOTE

 

This Amendment No. 1 on Form 10-K/A (this “Amendment”) amends the Annual Report on Form 10-K of Amyris, Inc. (the “Company”) for the fiscal year ended December 31, 2018 (the “Form 10-K”), as filed with the Securities and Exchange Commission (the “SEC”) on October 1, 2019 (the “Original Filing Date”).

 

This Amendment is being filed solely (i) for the purpose of furnishing Exhibit 101 (Interactive Data Files) to the Form 10-K, which was not included in the original filing of the Form 10-K with the SEC on the Original Filing Date, (ii) to correct administrative errors in the content of (A) the Report of Independent Registered Public Accounting Firm of BDO USA, LLP (the “BDO Report”), the Company’s independent registered public accounting firm for the fiscal year ended December 31, 2017, contained in Part II, Item 8 of the Form 10-K and (B) the Reports of Independent Registered Public Accounting Firm of Macias Gini & O’Connell LLP (the “MGO Reports”), the Company’s independent registered public accounting firm for the fiscal year ended December 31, 2018, contained in Part II, Item 8 and Part II, Item 9A of the Form 10-K, respectively and (iii) to correct certain other immaterial errors in Part II, Item 8 of the Form 10-K as set forth below.

 

The BDO Report and MGO Reports in the Form 10-K incorrectly contained certain references to September 30, 2019, when the correct date was October 1, 2019. Accordingly, such reports have been updated to refer to the correct date.

 

In addition, (i) certain references to “Contract assets” in the financial statement tables and related disclosure in Part II, Item 8 of the Form 10-K have been amended to refer to “Accounts receivable, unbilled – related party”, (ii) a line item for “Accounts receivable, unbilled, noncurrent - related party” has been added to the “Contract Balances” table in Note 10, “Revenue Recognition” in Part II, Item 8 of this Amendment, (iii) the amount of federal NOL and state NOL carryovers written off by the Company as a result of events occurring during the year ended December 31, 2017, disclosed in Note 14, “Income Taxes” in Part II, Item 8 of the Form 10-K, has been corrected, (iv) certain legend references and explanations in the tables in Note 2, “Restatement of 2017 Consolidated Financial Statements” and the “2017 and 2018 Quarterly Data – Restated Condensed Consolidated Financial Statements” section immediately after Note 16, “Subsequent Events” in Part II, Item 8 of the Form 10-K have been updated by deleting unused explanations, expanding or conforming certain explanations and adding certain explanations that were inadvertently excluded from such tables and (v) certain typographical errors in the financial statement tables and related disclosure in Part II, Item 8 of the Form 10-K have been corrected to conform to the correct disclosure provided elsewhere in Part II, Item 8 of the Form 10-K. 

 

No other changes have been made to the Form 10-K. This Amendment speaks as of the Original Filing Date and does not reflect events that may have occurred subsequent to the Original Filing Date, and, except as expressly set forth herein, does not modify or update in any way the disclosures made in the Form 10-K.

 

Pursuant to Rule 12b-15 promulgated under the Securities Exchange Act of 1934, this Amendment sets forth the complete text of Part II, Item 8 and Part II, Item 9A of the Form 10-K as amended hereby.  Part IV, Item 15 of this Amendment reflects (i) new consents of BDO USA, LLP and Macias Gini & O’Connell LLP, (ii) Exhibit 101 (Interactive Data Files) and (iii) new certifications pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 and Section 906 of the Sarbanes-Oxley Act of 2002, each of which is filed or furnished herewith, as applicable.

 

 

 

 

AMYRIS, INC.

 

FORM 10-K/A

FOR THE YEAR ENDED DECEMBER 31, 2018

TABLE OF CONTENTS 

 

 

PART II  
Item 8. Financial Statements and Supplementary Data 1
Item 9A. Controls and Procedures 114
   

PART IV

 
Item 15. Exhibits and Financial Statement Schedule 119

 

 

 

 

 

 

 

 

 

 

PART II

 

ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

 

AMYRIS, INC.

 

INDEX TO CONSOLIDATED FINANCIAL STATEMENTS

 

 

  Page
Reports of Independent Registered Public Accounting Firms 2
Consolidated Balance Sheets 4
Consolidated Statements of Operations 5
Consolidated Statements of Comprehensive Loss 6
Consolidated Statements of Stockholders' Deficit and Mezzanine Equity 7
Consolidated Statements of Cash Flows 8
Notes to Consolidated Financial Statements 10

 

 

 

 

 

 

 

 

 1 

 

 

Report of Independent Registered Public Accounting Firm

 

 

 

To the Board of Directors and Stockholders of Amyris, Inc.

 

Opinion on the Consolidated Financial Statements

We have audited the accompanying consolidated balance sheet of Amyris, Inc. and subsidiaries (the Company) as of December 31, 2018, the related consolidated statements of operations, comprehensive loss, stockholders’ deficit and mezzanine equity, and cash flows for the year then ended, and the related notes (collectively, the consolidated financial statements). In our opinion, the consolidated financial statements present fairly, in all material respects, the financial position of the Company as of December 31, 2018, and the results of their operations and their cash flows for the year then ended, in conformity with U.S. generally accepted accounting principles.

 

We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States) (“PCAOB”), the Company's internal control over financial reporting as of December 31, 2018, based on criteria established in Internal Control - Integrated Framework (2013) issued by the Committee of Sponsoring Organizations of the Treadway Commission (“COSO”) and our report dated October 1, 2019 expressed an adverse opinion thereon.

 

Going Concern

The accompanying consolidated financial statements have been prepared assuming that the Company will continue as a going concern. As discussed in Note 1 to the consolidated financial statements, the Company has suffered recurring losses from operations and has current debt service requirements that raise substantial doubt about its ability to continue as a going concern. Management’s plans in regard to these matters are also described in Note 1. The consolidated financial statements do not include any adjustments that might result from the outcome of this uncertainty.

 

Changes in Accounting Principles

As discussed in Notes 1 and 10 to the consolidated financial statements, the Company has changed its accounting method for recognizing revenue from contracts with customers in fiscal year 2018 due to the adoption of Topic 606, Revenue from Contracts with Customers, and all related amendments.

 

Basis for Opinion

These consolidated financial statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on these consolidated financial statements based on our audit. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (PCAOB) and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

 

We conducted our audit in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the consolidated financial statements are free of material misstatement, whether due to error or fraud.

 

Our audit included performing procedures to assess the risks of material misstatement of the consolidated financial statements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the consolidated financial statements. Our audit also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the consolidated financial statements. We believe that our audit provides a reasonable basis for our opinion.

 

/s/ Macias Gini & O'Connell LLP

 

We have served as the Company's auditor since 2019.

 

San Francisco, California

October 1, 2019

 

 2 

 

  

Report of Independent Registered Public Accounting Firm

 

 

 

To the Board of Directors and Stockholders

Amyris, Inc.

Emeryville, CA

 

Opinion on the Consolidated Financial Statements

 

We have audited the accompanying consolidated balance sheet of Amyris, Inc. as of December 31, 2017, the related consolidated statements of operations, comprehensive loss, stockholders’ deficit and mezzanine equity, and cash flows for the year then ended and the related notes (collectively referred to as the “consolidated financial statements”). In our opinion, the consolidated financial statements present fairly, in all material respects, the financial position of the Company at December 31, 2017 and the results of its operations and its cash flows for the year ended December 31, 2017, in conformity with accounting principles generally accepted in the United States of America.

 

Restatement to Correct 2017 Misstatements

 

As discussed in Note 2 to the consolidated financial statements, the 2017 financial statements have been restated to correct several misstatements.

 

Going Concern Uncertainty

 

The accompanying consolidated financial statements have been prepared assuming that the Company will continue as a going concern. As discussed in Note 1 to the consolidated financial statements, the Company has suffered recurring losses from operations and has a net capital deficiency and these factors, among others, raise substantial doubt about its ability to continue as a going concern. Management’s plans in regard to these matters are also described in Note 1. The consolidated financial statements do not include any adjustments that might result from the outcome of this uncertainty.

 

Basis for Opinion

 

These consolidated financial statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on the Company’s consolidated financial statements based on our audit. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (“PCAOB”) and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

 

We conducted our audit in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the consolidated financial statements are free of material misstatement, whether due to error or fraud.

 

Our audit included performing procedures to assess the risks of material misstatement of the consolidated financial statements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the consolidated financial statements. Our audit also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the consolidated financial statements. We believe that our audit provides a reasonable basis for our opinion.

 

/s/ BDO USA, LLP

We have served as the Company's auditor since 2019.

 

San Jose, California

October 1, 2019

 

 3 

 

 

AMYRIS, INC.

CONSOLIDATED BALANCE SHEETS

 

December 31,
(In thousands, except shares and per share amounts)
  2018  2017
      (As Restated, Note 2)
Assets          
Current assets:          
Cash and cash equivalents  $45,353   $57,059 
Restricted cash   741    2,994 
Accounts receivable, net of allowance of $642 and $619, respectively   16,003    18,953 
Accounts receivable related party, net of allowance of $0 and $23, respectively   1,349    4,767  
Accounts receivable, unbilled – related party   8,021    9,901 
Inventories   9,693    5,408 
Deferred cost of products sold, current - related party   489     
Prepaid expenses and other current assets   10,566    4,919 
Total current assets   92,215    104,001 
Property, plant and equipment, net   19,756    13,892 
Accounts receivable, unbilled, noncurrent - related party   1,203    

7,940

 
Deferred cost of products sold, noncurrent - related party   2,828     
Restricted cash, noncurrent   960    959 
Recoverable taxes from Brazilian government entities   3,005    1,445 
Other assets   7,958    12,559 
Total assets  $127,925   $140,796 
Liabilities, Mezzanine Equity and Stockholders' Deficit          
Current liabilities:          
Accounts payable  $26,844   $15,515 
Accrued and other current liabilities   28,979    29,202 
Contract liabilities(1)   8,236    4,308 
Debt, current portion (includes instrument measured at fair value of $57,918 and $0, respectively)   124,010    36,924 
Related party debt, current portion   23,667    20,019 
Total current liabilities   211,736    105,968 
Long-term debt, net of current portion   43,331    60,220 
Related party debt, net of current portion   18,689    46,541 
Derivative liabilities   42,796    116,497 
Other noncurrent liabilities   23,192    23,658 
Total liabilities   339,744    352,884 
Commitments and contingencies (Note 9)          
Mezzanine equity:          
Contingently redeemable common stock (Note 6)   5,000    5,000 
Stockholders’ deficit:          
Preferred stock - $0.0001 par value, 5,000,000 shares authorized as of December 31, 2018 and 2017, and 14,656 and 22,171 shares issued and outstanding as of December 31, 2018 and 2017, respectively        
Common stock - $0.0001 par value, 250,000,000 shares authorized as of December 31, 2018 and 2017, respectively; 76,564,829 and 45,637,433 shares issued and outstanding as of December 31, 2018 and 2017, respectively   8    5 
Additional paid-in capital   1,346,996    1,114,546 
Accumulated other comprehensive loss   (43,343)   (42,156)
Accumulated deficit   (1,521,417)   (1,290,420)
Total Amyris, Inc. stockholders’ deficit   (217,756)   (218,025)
Noncontrolling interest   937    937 
Total stockholders' deficit   (216,819)   (217,088)
Total liabilities, mezzanine equity and stockholders' deficit  $127,925   $140,796 

 

______________

(1)The balance in contract liabilities at December 31, 2017 represents deferred revenue, current prior to the Company's adoption of ASC 606, "Revenue".

 

See accompanying notes to consolidated financial statements.

 

 4 

 

 

AMYRIS, INC.

CONSOLIDATED STATEMENTS OF OPERATIONS

 

Years Ended December 31,
(In thousands, except shares and per share amounts)
  2018  2017
      (As Restated,
Note 2)
Revenue          
Renewable products (includes related party revenue of $360 and $1,291, respectively)  $33,598   $42,370 
Licenses and royalties, net (includes related party revenue of $5,958 and $57,972, respectively)   7,658    48,703 
Grants and collaborations (includes related party revenue of $4,735 and $1,679, respectively)   22,348    36,598 
Total revenue (includes related party revenue of $11,053 and $60,942, respectively)   63,604    127,671 
Cost and operating expenses          
Cost of products sold   36,698    62,307 
Research and development   68,722    57,562 
Sales, general and administrative   90,902    63,853 
Impairment of other assets   3,865     
Total cost and operating expenses   200,187    183,722 
Loss from operations   (136,583)   (56,051)
Other income (expense)          
(Loss) gain on divestiture   (1,778)   5,732 
Interest expense   (42,703)   (37,081)
Loss from change in fair value of derivative instruments   (30,880)   (48,852)
Gain from change in fair value of debt   2,082     
Loss upon extinguishment of debt   (17,424)   (11,897)
Other income (expense), net   (2,949)   (956)
Total other expense, net   (93,652)   (93,054)
Loss before income taxes   (230,235)   (149,105)
Provision for income taxes       (6,877)
Net loss attributable to Amyris, Inc.   (230,235)   (155,982)
Less deemed dividend related to beneficial conversion feature on Series A preferred stock       (562)
Less deemed dividend related to beneficial conversion feature on Series B preferred stock       (634)
Less deemed dividend related to beneficial conversion feature on Series D preferred stock       (5,757)
Less deemed dividend upon settlement of make-whole provision on Series A preferred stock       (10,505)
Less deemed dividend upon settlement of make-whole provision on Series B preferred stock       (22,632)
Less deemed dividend related to the recognition of discounts on Series A preferred stock upon conversion       (21,578)
Less deemed dividend related to the recognition of discounts on Series B preferred stock upon conversion       (24,366)
Less deemed dividend related to proceeds discount upon conversion of Series D preferred stock   (6,852)    
Add: losses allocated to participating securities   13,991    

40,159

 
Net loss attributable to Amyris, Inc. common stockholders  $(223,096)  $(201,857)
           
Weighted-average shares of common stock outstanding used in computing net loss per share of common stock, basic and diluted   60,405,910    32,253,570 
Basic and diluted loss per share  $(3.69)  $

(6.26

)

 

 

See accompanying notes to consolidated financial statements.

 

 5 

 

 

AMYRIS, INC.

CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS

 

 

Years Ended December 31,
(In thousands)
  2018  2017
      (As Restated,
Note 2)
Comprehensive loss:          
Net loss  $(230,235)  $(155,982)
Foreign currency translation adjustment   (1,187)   (1,252)
Comprehensive loss attributable to Amyris, Inc.  $(231,422)  $(157,234)

 

 

 

See accompanying notes to consolidated financial statements.

 

 

 6 

 

 

AMYRIS, INC.

CONSOLIDATED STATEMENTS OF STOCKHOLDERS' DEFICIT AND MEZZANINE EQUITY

 

   Preferred Stock  Common Stock                  
(In thousands, except number of shares)  Shares  Amount  Shares  Amount  Additional Paid-in Capital  Accumulated Other Comprehensive Loss  Accumulated Deficit  Noncontrolling Interest  Total Stockholders' Deficit  Mezzanine Equity - Common Stock
December 31, 2016           18,273,921   $2   $990,895   $(40,904)  $(1,134,438)  $937   $(183,508)  $5,000 
Issuance of Series A preferred stock for cash   22,140                562                562     
Issuance of Series B preferred stock upon conversion of debt, net of issuance costs of $0   40,204                11,530                11,530     
Issuance of Series B preferred stock for cash, net of issuance costs of $860   55,700                16,675                16,675     
Issuance of Series D preferred stock for cash, net of issuance costs of $176   12,958                6,197                6,197     
Issuance of common stock due to rounding from reverse stock split           6,473                             
Issuance of common stock for cash           2,826,711        5,527                5,527     
Issuance of common stock upon conversion of preferred stock   (108,831)       17,274,017    3                    3     
Issuance of common stock upon conversion of debt           2,257,786        

12,687

                

12,687

     
Issuance of common stock for settlement of debt principal payments           1,246,165        10,707                10,707     
Issuance of common stock for settlement of debt interest payments           400,967        3,436                3,436     
Issuance of common stock upon exercise of warrants           3,148,097        50,449                50,449     
Issuance of common stock upon restricted stock settlement           156,104        (385)               (385)    
Issuance of common stock upon ESPP purchase           47,058                             
Issuance of common stock upon exercise of stock options           134        

1

                

1

     
Beneficial conversion feature of Series A preferred stock                   562                562     
Deemed dividend on beneficial conversion feature of Series A preferred stock                   (562)               (562)    
Beneficial conversion feature to related party of Series B preferred stock                   634                634     
Deemed dividend to related party on beneficial conversion feature of Series B preferred stock                   (634)               (634)    
Beneficial conversion feature of Series D preferred stock                   5,757                5,757     
Deemed dividend on beneficial conversion feature of Series D preferred stock                   (5,757)               (5,757)    
Deemed dividend on preferred stock discounts upon conversion of Series A preferred stock                   21,578                21,578     
Deemed dividend on preferred stock discounts upon conversion of Series A preferred stock                   (21,578)               (21,578)    
Deemed dividend on preferred stock discounts upon conversion of Series B preferred stock                   24,366                24,366     
Deemed dividend on preferred stock discounts upon conversion of Series B preferred stock                   (24,366)               (24,366)    
Settlement of make-whole provision on Series A preferred stock                   

10,505

                10,505     
Deemed dividend upon settlement of make-whole provision on Series A preferred stock                   (10,505)               (10,505)    
Settlement of make-whole provision on Series B preferred stock                   22,632                22,632     
Deemed dividend upon settlement of make-whole provision on Series B preferred stock                   (22,632)               (22,632)    
Stock-based compensation                   6,265                6,265     
Foreign currency translation adjustment                       (1,252)           (1,252)    
Net loss (As Restated, Note 2)                           (155,982)       (155,982)    
                                                   
December 31, 2017 (As restated, Note 2)   22,171        45,637,433   $5   $1,114,546   $(42,156)  $(1,290,420)  $937   $(217,088)  $5,000 
Cumulative effect of change in accounting principle for ASC 606 (see "Significant Accounting Policies" in Note 1)                           (762)       (762)    
Issuance of common stock upon exercise of warrants           20,891,038    2    62,152                62,154     
Settlement of derivatives liability upon exercise of warrants                   108,670                108,670      
Issuance of common stock in private placement, net of issuance costs of $0           205,168        1,415                1,415     
Issuance of common stock in private placement - related party, net of issuance costs of $0           1,643,991        6,050                6,050     
Issuance of common stock upon conversion of preferred stock   (7,515)       1,548,480                             
Deemed dividend on preferred stock discounts upon conversion of Series D preferred stock                   

6,852

                

6,852

     
Deemed dividend on preferred stock discounts upon conversion of Series D preferred stock                   (6,852)               (6,852)    
Issuance of common stock upon conversion of convertible notes           5,674,926    1    42,368                42,369     
Issuance of common stock for settlement of debt interest payments           238,898        1,800                1,800     
Issuance of common stock upon exercise of stock options           70,807        288                288     
Issuance of common stock upon ESPP purchase           246,230        777                777     
Issuance of common stock and payment of minimum employee taxes withheld upon net share settlement of restricted stock           407,858        (260)               (260)    
Stock-based compensation                   9,190                9,190     
Foreign currency translation adjustment                       (1,187)           (1,187)    
Net loss                           (230,235)       (230,235)    
December 31, 2018   14,656        76,564,829   $8   $1,346,996   $(43,343)  $(1,521,417)  $937   $(216,819)  $5,000 

 

 

See accompanying notes to consolidated financial statements.

 

 7 

 

 

AMYRIS, INC.

CONSOLIDATED STATEMENTS OF CASH FLOWS

 

Years Ended December 31,  2018  2017
(In thousands)     (As Restated, Note 2)
Operating activities          
Net loss  $(230,235)  $(155,982)
Adjustments to reconcile net loss to net cash used in operating activities:          
Loss from change in fair value of derivative liabilities   30,880    48,852 
Loss upon conversion or extinguishment of debt   17,424    

11,897

 
Amortization of debt discount   16,602    

15,239

 
Stock-based compensation   9,190    6,265 
Modification of warrants recorded as legal expense   6,764     
Depreciation and amortization   4,921    11,358 
Issuance costs on warrant exercises for cash   4,389     
Loss on impairment of other assets   3,865     
Debt issuance costs expensed due to fair value option   3,810     
Loss (gain) on divestiture   1,778    (5,732)
Loss on disposal of property, plant and equipment   941    142 
Gain on foreign currency exchange rates   (2,223)   (1,230)
Gain from change in fair value of debt   (2,082)    
Noncash revenue reduction related to issuance of debt obligations under Ginkgo Partnership Agreement       

13,413

 
Receipt of noncash consideration in connection with license revenue       (8,046)
Changes in assets and liabilities:          
Accounts receivable   7,448    (19,647)
Accounts receivable, unbilled – related party   8,056    (7,940)
Inventories   (4,416)   (3,126)
Deferred cost of products sold   (3,317)    
Prepaid expenses and other assets   (6,383)   (18,730)
Accounts payable   11,603    5,452 
Accrued and other liabilities   

8,461

    

13,877

 
Contract liabilities   3,158   (7,241)
Net cash used in operating activities   (109,366)   (101,179)
Investing activities          
Purchases of property, plant and equipment   (12,472)   (4,412)
Proceeds from divestiture, net of cash transferred       54,827 
Maturities of short-term investments       12,403 
Sale of short-term investments       676 
Purchase of short-term investments       (11,786)
Net cash (used in) provided by investing activities   (12,472)   51,708 
Financing activities          
Proceeds from issuance of debt, net of issuance costs   94,371    18,925 
Proceeds from exercise of warrants, net of issuance costs   57,767     
Proceeds from issuance of common stock in private placements, net of issuance costs   1,415     
Proceeds from ESPP purchases   777     
Proceeds from exercises of common stock options   288     
Principal payments on debt   (41,668)   (37,500)
Debt issuance costs incurred in connection with debt instrument accounted at fair value   (3,752)    
Principal payments on capital leases   (981)    
Payment of minimum employee taxes withheld upon net share settlement of restricted stock units   (260)   (385)
Proceeds from issuance of convertible preferred stock       

98,246

 
Proceeds from issuance of common stock in August 2017 offering       

5,759

 
Issuance costs incurred       (2,159)
Payment of swap termination       (3,113)
Payment on early redemption of debt       (1,909)
Net cash provided by financing activities   107,957    77,864 
Effect of exchange rate changes on cash, cash equivalents and restricted cash   (77)   186 
Net (decrease) increase in cash, cash equivalents and restricted cash   (13,958)   28,579 
Cash, cash equivalents and restricted cash at beginning of year   61,012    32,433 
Cash, cash equivalents and restricted cash at end of year  $47,054   $61,012 
           
Reconciliation of cash, cash equivalents and restricted cash to the consolidated balance sheets          
Cash and cash equivalents  $45,353   $57,059 
Restricted cash, current   741    2,994 
Restricted cash, noncurrent   960    959 
Total cash, cash equivalents and restricted cash  $47,054   $61,012 

 

 

 8 

 

 

 

Amyris, Inc.

CONSOLIDATED STATEMENTS OF CASH FLOWS, Continued

 

Years Ended December 31,
(In thousands)
  2018  2017
      (As Restated, Note 2)
Supplemental disclosures of cash flow information:          
Cash paid for interest  $18,524   $11,539 
Supplemental disclosures of non-cash investing and financing activities:          
Derecognition of derivative liabilities upon exercise of warrants  $108,670   $ 
Issuance of common stock upon conversion of convertible notes  $24,970   $28,702 
Issuance of common stock - related party  $6,050   $ 
Accrued interest added to debt principal  $3,664   $2,816 
Issuance of common stock for settlement of debt principal and interest payments  $1,800   $3,436 
Cumulative effect adjustment of ASC 606  $762   $ 
Financing of insurance premium under note payable  $495   $467 
Financing of equipment under financing leases  $271   $ 
Issuance of preferred stock attributed to derivative liabilities   $   $

72,725

 
Issuance of convertible preferred stock upon conversion of debt  $   $40,204 
Settlement of debt principal by a related party  $   $25,000 
Issuance of note payable in exchange for debt extinguishment with third party  $   $16,954 
Issuance of common stock for settlement of debt  $   $10,708 

  

See accompanying notes to consolidated financial statements.

 

 9 

 

 

Amyris, Inc.

Notes to Consolidated Financial Statements

 

1. Basis of Presentation and Summary of Significant Accounting Policies

 

Business Description

 

Amyris, Inc. (Amyris or the Company) is a leading industrial biotechnology company that applies its technology platform to engineer, manufacture and sell high performance, natural, sustainably-sourced products into the Health & Wellness, Clean Beauty, and Flavor & Fragrance markets. The Company's proven technology platform enables the Company to rapidly engineer microbes and use them as catalysts to metabolize renewable, plant-sourced sugars into large volume, high-value ingredients. The Company's biotechnology platform and industrial fermentation process replace existing complex and expensive manufacturing processes. The Company has successfully used its technology to develop and produce several distinct molecules at commercial volumes.

 

Going Concern

 

The Company has incurred significant operating losses since its inception and expects to continue to incur losses and negative cash flows from operations for at least the next 12 months following the issuance of the financial statements. As of December 31, 2018, the Company had negative working capital of $119.5 million and an accumulated deficit of $1.5 billion.

 

As of December 31, 2018, the Company's debt (including related party debt), net of deferred discount and issuance costs of $17.1 million and a change in fair value of $2.1 million, totaled $209.7 million, of which $147.7 million is classified as current. The Company's debt agreements contain various covenants, including certain restrictions on the Company's business that could cause the Company to be at risk of defaults, such as restrictions on additional indebtedness, material adverse effect and cross default clauses. A failure to comply with the covenants and other provisions of the Company’s debt instruments, including any failure to make a payment when required, would generally result in events of default under such instruments, which could permit acceleration a substantial portion of such indebtedness. If such indebtedness is accelerated, it would generally also constitute an event of default under the Company’s other outstanding indebtedness, permitting acceleration of a substantial portion of such other outstanding indebtedness. At December 31, 2018, the Company failed to meet certain covenants in connection with the GACP Term Loan Facility (see Note 5, “Debt”), including those associated with minimum revenue and minimum liquidity requirements. In April 2019, (i) GACP provided a waiver to the Company for breaches of all covenant violations under the GACP loan and security agreement (LSA) occurring prior to, as of and after December 31, 2018 through April 8, 2019, and (ii) GACP sold and assigned the loans under the LSA and all documents and assets related thereto to Foris Ventures, LLC (Foris). Subsequently, Foris provided a waiver to the Company for breaches of certain covenants under the LSA through June 30, 2020 and amended the financial covenants under the LSA to provide more favorable compliance terms and conditions. See Note 16, "Subsequent Events" for additional information.

 

Cash and cash equivalents of $45.4 million as of December 31, 2018 are not sufficient to fund expected future negative cash flows from operations and cash debt service obligations through September 30, 2020. These factors raise substantial doubt about the Company’s ability to continue as a going concern within one year after the date that these financial statements are issued. The consolidated financial statements do not include any adjustments that might result from the outcome of this uncertainty. The Company's ability to continue as a going concern will depend, in large part, on its ability to achieve positive cash flows from operations during the 12 months from the date of this filing, and refinance or extend other existing debt maturities occurring later in 2019, all of which are uncertain and outside the control of the Company. Further, the Company's operating plan for 2019 contemplates a significant reduction in its net operating cash outflows as compared to the year ended December 31, 2018, resulting from (i) revenue growth from sales of existing and new products with positive gross margins, (ii) reduced production costs as a result of manufacturing and technical developments, and (iii) an increase in cash inflows from collaborations and grants. If the Company is unable to complete these actions, it expects to be unable to meet its operating cash flow needs and its obligations under its existing debt facilities. This could result in an acceleration of its obligation to repay all amounts outstanding under those facilities, and the Company may be forced to obtain additional equity or debt financing, which may not occur timely or on reasonable terms, if at all, and/or liquidate its assets. In such a scenario, the value received for assets in liquidation or dissolution could be significantly lower than the value reflected in these financial statements. The Company has in the past, including in July 2019, had certain of its debt instruments accelerated for failure to make a payment when due. While we have been able to cure these defaults to date to avoid additional cross-acceleration, we may not be able to cure such a default promptly in the future.

 

 10 

 

 

On September 16, 2019, the Company failed to pay an aggregate of $63.6 million of outstanding principal and accrued interest on the Second Exchange Note when due. The failure resulted in an event of default under the Second Exchange Note and also triggered cross-defaults under other debt instruments of the Company which permitted the holders of such indebtedness to accelerate the amounts owing under such instruments. The Company subsequently received waivers from substantially all holders of such other debt instruments to waive the right to accelerate. As a result, the indebtedness with respect to which the Company has obtained such waivers continues to be classified as long-term on the Company’s balance sheet.  The indebtedness reflected by the Second Exchange Note continues to be classified as a current liability on the Company’s balance sheet. In addition, as a result of the payment default, the conversion price of the Second Exchange Note is subject to adjustment in accordance with the terms of the Second Exchange Note.

 

The Company does not currently have sufficient funds to repay the amounts outstanding under the Second Exchange Note. To date, negotiations with the holder of the Second Exchange Note have not been successful, and there can be no assurance that a favorable outcome for the Company will be reached. The Company has executed a term sheet with an existing investor for a term loan, the proceeds of which would be used to repay a portion of the Second Exchange Note. However, there can be no assurance that the Company will be able to obtain such financing on its expected timeline, or on acceptable terms, if at all. Even if the Company does obtain such financing, it will not have sufficient funds to repay the Second Exchange Note in full without obtaining additional financing, which the Company is attempting to source. The consolidated financial statements do not include any adjustments that might result from the outcome of this uncertainty.

 

Basis of Consolidation

 

The accompanying consolidated financial statements have been prepared in accordance with the accounting principles generally accepted in the United States (U.S. GAAP). The consolidated financial statements include the accounts of Amyris, Inc. and its wholly-owned and partially-owned subsidiaries in which the Company has a controlling interest after elimination of all significant intercompany accounts and transactions.

 

Investments and joint venture arrangements are assessed to determine whether the terms provide economic or other control over the entity requiring consolidation of the entity. Entities controlled by means other than a majority voting interest are referred to as variable-interest entities (VIEs) and are consolidated when Amyris has both the power to direct the activities of the VIE that most significantly impact its economic performance and the obligation to absorb losses or the right to receive benefits that could potentially be significant to the entity. For any investment or joint venture in which (i) the Company does not have a majority ownership interest, (ii) the Company possesses the ability to exert significant influence and (iii) the entity is not a VIE for which the Company is considered the primary beneficiary, the Company accounts for the investment or joint venture using the equity method. Following the adoption of ASU 2016-01 on January 1, 2018 described in more detail below (which was applicable to the Company on a prospective basis), equity investments in which the Company does not exert significant influence and that do not have readily determinable fair values are measured at cost, adjusted for changes from observable market transactions, less impairment (“adjusted cost basis”). The Company evaluates its investments for impairment by considering a variety of factors, including the earnings capacity of the related investments. Fair value measurements for the Company’s equity investments are classified within Level 3 of the fair value hierarchy based on the nature of the fair value inputs. Realized and unrealized gains or losses are recognized in other income or expense.

 

Sale of Subsidiary and Entry into Commercial Agreements

 

On December 28, 2017, the Company completed the sale of all of the capital stock of its subsidiary Amyris Brasil, a wholly-owned subsidiary, to DSM Produtos Nutricionais Brasil S.A (DSM), a related party. Amyris Brasil owned and operated the Company’s production facility in Brotas, Brazil. The transaction resulted in a pretax gain of $5.7 million from continuing operations in 2017, which was further adjusted by a $1.8 million loss in 2018 related to the final working capital adjustments between the Company and DSM. The transaction did not result in presenting Amyris Brasil as a discontinued operation in the consolidated financial statements, as the sale did not represent a strategic shift that will have a major effect on the Company’s operations and financial results due to the Company’s continuing commercial presence and reinvestment in a new production facility under construction in Brazil and its continuing Brazilian operation through Amyris Biotecnologia do Brasil Ltda. (formerly SMA Indústria Química Ltda.). The Company and DSM also entered into a series of commercial agreements and a credit agreement concurrently with the sale of Amyris Brasil. See Note 10, “Revenue Recognition”, Note 11, “Related Party Transactions”, Note 13, “Divestiture” and Note 16, “Subsequent Events” for further information.

 

Use of Estimates and Judgements

 

The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates, judgements and assumptions that affect the reported amounts of assets and liabilities, disclosures of contingent assets and liabilities at the date of the financial statements, and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates, and such differences may be material to the consolidated financial statements.

 

 11 

 

 

Significant Accounting Policies

 

Cash and Cash Equivalents

 

The Company considers all highly liquid investments purchased with an original or remaining maturity of three months or less at the date of purchase to be cash equivalents. Cash and cash equivalents are maintained with various financial institutions.

 

Inventories

 

Inventories, which consist of farnesene-derived products, flavors and fragrances ingredients and clean beauty products, are stated at the lower of actual cost or net realizable value and are categorized as finished goods, work in process or raw material inventories. The Company evaluates the recoverability of its inventories based on assumptions about expected demand and net realizable value. If the Company determines that the cost of inventories exceeds their estimated net realizable value, the Company records a write-down equal to the difference between the cost of inventories and the estimated net realizable value. If actual net realizable values are less favorable than those projected by management, additional inventory write-downs may be required that could negatively impact the Company's operating results. If actual net realizable values are more favorable, the Company may have favorable operating results when products that have been previously written down are sold in the normal course of business. The Company also evaluates the terms of its agreements with its suppliers and establishes accruals for estimated losses on adverse purchase commitments as necessary, applying the same lower of cost or net realizable value approach that is used to value inventory. Cost is computed on a weighted-average basis.

 

Property, Plant and Equipment, Net

 

Property, plant and equipment are recorded at cost. Depreciation and amortization are computed straight-line based on the estimated useful lives of the related assets, ranging from 3 to 15 years for machinery, equipment and fixtures, and 15 years for buildings. Leasehold improvements are amortized over their estimated useful lives or the period of the related lease, whichever is shorter.

 

The Company expenses costs for maintenance and repairs and capitalizes major replacements, renewals and betterments. For assets retired or otherwise disposed, both cost and accumulated depreciation are eliminated from the asset and accumulated depreciation accounts, and gains or losses related to the disposal are recorded in the statement of operations for the period.

 

Impairment

 

Long-lived assets that are held and used by the Company are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount of such assets may not be recoverable. Determination of recoverability of long-lived assets is based on an estimate of the undiscounted future cash flows resulting from the use of the asset and its eventual disposition. Measurement of an impairment loss for long-lived assets that management expects to hold and use is based on the difference between the fair value of the asset and its carrying value. Long-lived assets to be disposed of are reported at the lower of carrying amount or fair value less costs to sell.

 

 12 

 

Recoverable Taxes from Brazilian Government Entities

 

Recoverable taxes from Brazilian government entities represent value-added taxes paid on purchases in Brazil, which are reclaimable from the Brazilian tax authorities, net of reserves for amounts estimated not to be recoverable.

 

Fair Value Measurements

 

The carrying amounts of certain financial instruments, such as cash equivalents, short-term investments, accounts receivable, accounts payable and accrued liabilities, approximate fair value due to their relatively short maturities.

 

The Company measures the following financial assets and liabilities at fair value:

Freestanding and bifurcated derivatives in connection with certain debt and equity financings; and
6% Convertible Notes Due 2021 (see Note 4, "Fair Value Measurement", Note 5, "Debt" and Note 16, “Subsequent Events”), for which the Company has elected fair value accounting

 

Fair value is based on the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants. Where available, fair value is based on or derived from observable market prices or other observable inputs. Where observable prices or inputs are not available, valuation techniques are applied. These valuation techniques involve some level of management estimation and judgement, the degree of which is dependent on the price transparency for the instruments or market and the instruments’ complexity.

 

Changes to the inputs used in these valuation models have a significant impact on the estimated fair value of the 6% Convertible Notes Due 2021 and the Company's embedded and freestanding derivatives. For example, a decrease (increase) in the estimated credit spread for the Company results in an increase (decrease) in estimated fair value. Conversely, a decrease (increase) in the stock price results in a decrease (increase) in estimated fair value.

 

The changes during 2018 and 2017 in the fair values of the bifurcated compound embedded derivatives are primarily related to the change in price of the Company's common stock and are reflected in the consolidated statements of operations as “Gain (loss) from change in fair value of derivative instruments”.

 

For debt instruments for which the Company has not elected fair value accounting, fair value is based on the present value of expected future cash flows and assumptions about the then-current market interest rates as of the reporting period and the creditworthiness of the Company. Most of the Company's debt is carried on the consolidated balance sheet on a historical cost basis net of unamortized discounts and premiums, because the Company has not elected the fair value option of accounting. However, for the 6% Notes Due 2021, the Company elected fair value accounting, so that balances reported for that debt instrument represent fair value as of each balance sheet date; see Note 4, "Fair Value Measurement", for additional information. Changes in fair value of the 6% Convertible Notes Due 2021 are reflected in the consolidated statements of operations as “Gain (loss) from change in fair value of debt”.

 

For all debt instruments, including any for which the Company has elected fair value accounting, the Company classifies interest that has been accrued during each period as Interest expense on the consolidated statements of operations.

 

Derivatives

 

Embedded derivatives that are required to be bifurcated from the underlying debt instrument (i.e., host) are accounted for and valued as separate financial instruments. The Company has evaluated the terms and features of its convertible notes payable and convertible preferred stock and identified compound embedded derivatives requiring bifurcation and accounting at fair value, using the valuation techniques mentioned in the Fair Value Measurements section of this Note, because the economic and contractual characteristics of the embedded derivatives met the criteria for bifurcation and separate accounting due to the instruments containing conversion options, certain “make-whole interest” provisions, down-round conversion price adjustment provisions and/or conversion rate adjustments.

 

 13 

 

Cash warrants and anti-dilution warrants issued in conjunction with the convertible debt and equity financings are freestanding financial instruments which are also classified as derivative liabilities.

 

Noncontrolling Interest

 

Noncontrolling interests represent the portion of net income (loss), net assets and comprehensive income (loss) that is not allocable to the Company, in situations where the Company consolidates its equity investment in a joint venture for which there are other owners. The amount of noncontrolling interest is comprised of the amount of such interests at the date of the Company's original acquisition of an equity interest in a joint venture, plus the other shareholders' share of changes in equity since the date the Company made an investment in the joint venture.

 

Concentration of Credit Risk

 

Financial instruments that potentially subject the Company to a concentration of credit risk consist primarily of cash and cash equivalents, short-term investments and accounts receivable. The Company places its cash equivalents and investments (primarily certificates of deposits) with high credit quality financial institutions and, by policy, limits the amount of credit exposure with any one financial institution. Deposits held with banks may exceed the amount of insurance provided on such deposits. The Company has not experienced any losses on its deposits of cash and cash equivalents and short-term investments.

 

The Company performs ongoing credit evaluation of its customers, does not require collateral, and maintains allowances for potential credit losses on customer accounts when deemed necessary.

 

Customers representing 10% or greater of accounts receivable were as follows:

 

As of December 31,  2018  2017
Customer B   24%   10%
Customer C   19%   15%
Customer G    11%   **
Customer A (related party)   **    38%

______________

** Less than 10%

 

Customers representing 10% or greater of revenue were as follows:

 

Years Ended December 31,  2018  2017
      (As Restated, Note 2)
Customer A (related party)   17%   46%
Customer B   18%   13%
Customer C   13%   ** 
Customer D   13%   ** 
Customer E   **    11%
Customer F   **    ** 

 

______________

** Less than 10%

 

Revenue Recognition

 

Year ended December 31, 2017

 

For the year ended December 31, 2017, the Company recognized revenue from the sale of renewable products, licenses of and royalties from intellectual property, and grants and collaborative research and development services. Revenue was recognized when all of the following criteria were met: persuasive evidence of an arrangement existed, delivery has occurred or services have been rendered, the fee was fixed or determinable, and collectability was reasonably assured. If sales arrangements contained multiple elements, the Company evaluated whether the components of each arrangement represent separate units of accounting.

 

 14 

 

 

Renewable Product Sales

 

The Company’s renewable product sales do not include rights of return, except for sales of Biossance products. Returns are only accepted if the product does not meet product specifications and such nonconformity is communicated to the Company within a set number of days of delivery. The Company offers a two-year standard warranty provision for squalane products, if the products do not meet Company-established criteria as set forth in the Company’s trade terms. The Company bases its return reserve on a historical rate of return for the Company’s squalane products. Revenues are recognized, net of discounts and allowances, once passage of title and risk of loss has occurred and contractually specified acceptance criteria have been met, provided all other revenue recognition criteria have also been met.

 

Licenses and Royalties

 

License fees for intellectual property transferred to other parties, representing non-refundable payments received at the time of signature of license agreements, are recognized as revenue upon signature of the license agreements when the Company has no significant future performance obligations and collectability of the fees is assured. Upfront payments received at the beginning of licensing agreements with future service obligations are deferred and recognized as revenue on a systematic basis over the period during which the related services are rendered and all obligations are performed.

 

Royalties from intellectual property licenses that allow Amyris's customers to use the Company’s intellectual property to produce and sell their products in which the Company shares in the profits are recognized in the period the royalty report is received.

 

Grants and Collaborative Research and Development Services

 

Revenues from collaborative research and development services are recognized as the services are performed consistent with the performance requirements of the contract. In cases where the planned levels of research and development services fluctuate over the research term, the Company recognizes revenues using the proportional performance method based upon actual efforts to date relative to the amount of expected effort to be incurred by us. When up-front payments are received and the planned levels of research and development services do not fluctuate over the research term, revenues are recorded on a ratable basis over the arrangement term, up to the amount of cash received. When up-front payments are received and the planned levels of research and development services fluctuate over the research term, revenues are recorded using the proportional performance method, up to the amount of cash received. Where arrangements include milestones that are determined to be substantive and at risk at the inception of the arrangement, revenues are recognized upon achievement of the milestone and is limited to those amounts whereby collectability is reasonably assured.

 

Grants are agreements that generally provide cost reimbursement for certain types of expenditures in return for research and development activities over a contractually defined period. Revenues from grants are recognized in the period during which the related costs are incurred, provided that the conditions under which the grants were provided have been met and only perfunctory obligations are outstanding.

 

Year ended December 31, 2018

 

In accordance with a new revenue recognition standard that the Company adopted January 1, 2018, the Company recognizes revenue from the sale of renewable products, licenses of and royalties from intellectual property, and grants and collaborative research and development services. Revenue is measured based on the consideration specified in a contract with a customer, and transaction price is allocated utilizing stand-alone selling price. Revenue is recognized when, or as, the Company satisfies a performance obligation by transferring control over a product or service to a customer. The Company generally does not incur costs to obtain new contracts. The costs to fulfill a contract are expensed as incurred.

 

The Company accounts for a contract when it has approval and commitment to perform from both parties, the rights of the parties are identified, payment terms are established, the contract has commercial substance and collectability of the consideration is probable. Changes to contracts are assessed for whether they represent a modification or should be accounted for as a new contract. The Company considers the following indicators, among others, when determining if it is acting as a principal in the transaction and recording revenue on a gross basis: (i) the Company is primarily responsible for fulfilling the promise to provide the specified goods or service, (ii) the Company has inventory risk before the specified good or service has been transferred to a customer or after transfer of control to the customer and (iii) the Company has discretion in establishing the price for the specified good or service. If a transaction does not meet the Company's indicators of being a principal in the transaction, then the Company is acting as an agent in the transaction and the associated revenues are recognized on a net basis.

 

 15 

 

The Company’s significant contracts and contractual terms with its customers are presented in Note 10, "Revenue Recognition".

 

The Company recognizes revenue when control has passed to the customer. The following indicators are evaluated in determining when control has passed to the customer: (i) the Company has a right to receive payment for the product or service, (ii) the customer has legal title to the product, (iii) the Company has transferred physical possession of the product to the customer, (iv) the customer has the significant risk and rewards of ownership of the product and (v) the customer has accepted the product. For most of the Company's renewable products customers, supply agreements between the Company and each customer indicate when transfer of title occurs.

 

In some cases, the Company may make a payment to a customer. When that occurs, the Company evaluates whether the payment is for a distinct good or service receivable from the customer. If the fair value of the goods or services receivable is greater than or equal to the amount paid to the customer, then the entire payment is treated as a purchase. If, on the other hand, the fair value of goods or services is less than the amount paid, then the difference is treated as a reduction in transaction price of the Company's sales to the customer.

 

Performance Obligations

 

A performance obligation is a promise in a contract to transfer a distinct good or service to the customer. A contract’s transaction price is allocated to each distinct performance obligation and recognized as revenue when, or as, the performance obligation is satisfied. The Company's contracts may contain multiple performance obligations if a promise to transfer the individual goods or services is separately identifiable from other promises in the contracts and, therefore, is considered distinct. For contracts with multiple performance obligations, the Company determines the standalone selling price of each performance obligation and allocates the total transaction price using the relative selling price basis.

 

The following is a description of the principal goods and services from which the Company generates revenue.

 

Renewable Product Sales

 

Revenues from renewable product sales are recognized as a distinct performance obligation on a gross basis as the Company is acting as a principal in these transactions, with the selling price to the customer recorded net of discounts and allowances. Revenues are recognized at a point in time when control has passed to the customer, which typically is upon the renewable products leaving the Company’s facilities with the first transportation carrier. The Company, on occasion, may recognize revenue under a bill and hold arrangement, whereby the customer requests and agrees to purchase product but requests delivery at a later date. Under these arrangements, control transfers to the customer when the product is ready for delivery, which occurs when the product is identified separately as belonging to the customer, the product is ready for shipment to the customer in its current form, and the Company does not have the ability to direct the product to a different customer. It is at this point that the Company has the right to receive payment, the customer obtains legal title, and the customer has the significant risks and rewards of ownership. The Company’s renewable product sales do not include rights of return, except for Biossance products, for which the Company estimates sales returns subsequent to sale and reduces revenue accordingly. For renewable products other than Biossance, returns are accepted only if the product does not meet product specifications and such nonconformity is communicated to the Company within a set number of days of delivery. The Company offers a two-year assurance-type warranty to replace squalane products that do not meet Company-established criteria as set forth in the Company’s trade terms. An estimate of the cost to replace the squalane products sold is made based on a historical rate of experience and recognized as a liability and related expense when the renewable product sale is consummated.

 

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Licenses and Royalties

 

Licensing of Intellectual Property: When the Company’s intellectual property licenses are determined to be distinct from the other performance obligations identified in the arrangement, revenue is recognized from non-refundable, up-front fees allocated to the license at a point in time when the license is transferred to the licensee and the licensee is able to use and benefit from the license. For intellectual property licenses that are combined with other promises, the Company utilizes judgment to assess the nature of the combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purposes of recognizing revenue from non-refundable, up-front-fees. The Company evaluates the measure of progress each reporting period and, if necessary, adjusts the measure of performance and related revenue recognized.

 

Royalties from Licensing of Intellectual Property: The Company earns royalties from the licensing of its intellectual property whereby the licensee uses the intellectual property to produce and sell its products to its customers and the Company shares in the profits.

 

When the Company’s intellectual property license is the only performance obligation, or it is the predominant performance obligation in arrangements with multiple performance obligations, the Company applies the sales-based royalty exception which requires the Company to estimate the revenue that is recognized at a point in time when the licensee’s product sales occur. Estimates of sales-based royalty revenues are made using the most likely outcome method, which is the single amount in a range of possible amounts, using the best evidence available at the time, derived from the licensee’s historical sales volumes and sales prices of its products and recent commodity market pricing data and trends. Estimates are adjusted to actual or as new information becomes available.

 

When the Company’s intellectual property license is not the predominant performance obligation in arrangements with multiple performance obligations, the royalty represents variable consideration and is allocated to the transaction price of the predominant performance obligation which generally is the supply of renewable products to the Company's customers. Revenue is estimated and recognized at a point in time when the renewable products are delivered to the customer. Estimates of the amount of variable consideration to include in the transaction price are made using the expected value method, which is the sum of probability-weighted amounts in a range of possible amounts determined based on the cost to produce the renewable product plus a reasonable margin for the profit share. The Company only includes an amount of variable consideration in the transaction price to the extent it is probable that a significant reversal in the cumulative revenue recognized will not occur when the uncertainty associated with the variable consideration is subsequently resolved. Also, the transaction price is reduced for estimates of customer incentive payments payable by the Company for certain customer contracts.

 

Grants and Collaborative Research and Development Services

 

Collaborative Research and Development Services: The Company earns revenues from collaboration agreements with customers to perform research and development services to develop new molecules using the Company’s technology and to scale production of the molecules for commercialization and use in the collaborator’s products. The collaboration agreements generally include providing the Company's collaboration partners with research and development services and with licenses to the Company’s intellectual property to use the technology underlying the development of the molecules and to sell its products that incorporate the technology. The terms of the Company's collaboration agreements typically include one or more of the following: advance payments for the research and development services that will be performed, nonrefundable upfront license payments, milestone payments to be received upon the achievement of the milestone events defined in the agreements, and royalty payments upon the commercialization of the molecules in which the Company shares in the customer’s profits.

 

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Collaboration agreements are evaluated at inception to determine whether the intellectual property licenses represent distinct performance obligations separate from the research and development services. If the licenses are determined to be distinct, the non-refundable upfront license fee is recognized as revenue at a point in time when the license is transferred to the licensee and the licensee is able to use and benefit from the license while the research and development service fees are recognized over time as the performance obligations are satisfied. The research and development service fees represent variable consideration. Estimates of the amount of variable consideration to include in the transaction price are made using the expected value method, which is the sum of probability-weighted amounts in a range of possible amounts. The Company only includes an amount of variable consideration in the transaction price to the extent it is probable that a significant reversal in the cumulative revenue recognized will not occur when the uncertainty associated with the variable consideration is subsequently resolved. Revenue is recognized over time using either an input-based measure of labor hours expended or a time-based measure of progress towards the satisfaction of the performance obligations. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized.

 

Collaboration agreements that include milestone payments are evaluated at inception to determine whether the milestone events are considered probable of achievement, and estimates are made of the amount of the milestone payments to include in the transaction price using the most likely amount method which is the single amount in a range of possible amounts. If it is probable that a significant revenue reversal will not occur, the estimated milestone payment amount is included in the transaction price. Each reporting period, the Company re-evaluates the probability of achievement of the milestone events and any related constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative basis, which would affect collaboration revenues in the period of adjustment. Generally, revenue is recognized using an input-based measure of progress towards the satisfaction of the performance obligations which can be labor hours expended or time-based in proportion to the estimated total project effort or total projected time to complete. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized. Certain performance obligations are associated with milestones agreed between the Company and its customer. Revenue generated from the performance of services in accordance with these milestones is recognized upon confirmation from the customer that the milestone has been achieved. In these cases, amounts recognized are constrained to the amount of consideration received upon achievement of the milestone. 

 

The Company generally invoices its collaboration partners on a monthly or quarterly basis, or upon the completion of the effort or achievement of a milestone, based on the terms of each agreement. Deferred revenue arises from amounts received in advance of performing the research and development activities and is recognized as revenue in future periods as the performance obligations are satisfied.

 

Grants: The Company earns revenues from grants with government agencies to, among other things, provide research and development services to develop molecules using the Company’s technology, and create research and development tools to improve the timeline and predictability for scaling molecules from proof of concept to market by reducing time and costs. Grants typically consist of research and development milestone payments to be received upon the achievement of the milestone events defined in the agreements.

 

The milestone payments are evaluated at inception to determine whether the milestone events are considered probable of achievement and estimates are made of the amount of the milestone payments to include in the transaction price using the most likely amount method which is the single amount in a range of possible amounts. If it is probable that a significant revenue reversal will not occur, the estimated milestone payment amount is included in the transaction price. Each reporting period, the Company re-evaluates the probability of achievement of the milestone events and any related constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative basis, which would affect grant revenues in the period of adjustment. Revenue is recognized over time using a time-based measure of progress towards the satisfaction of the performance obligations. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized.

 

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Cost of Products Sold

 

Cost of products sold includes the production costs of renewable products, which include the cost of raw materials, in-house manufacturing labor and overhead, amounts paid to contract manufacturers, including amortization of tolling fees, and period costs including inventory write-downs resulting from applying lower of cost or net realizable value inventory adjustments. Cost of products sold also includes certain costs related to the scale-up of production. Shipping and handling costs charged to customers are recorded as revenues. Outbound shipping costs incurred are included in cost of products sold. Such charges were not material for any of the periods presented.

 

The Company recognizes deferred cost of products sold as an asset on the balance sheet when a cost is incurred in connection with a revenue performance obligation that will not be fulfilled until a future period.

 

Research and Development

 

Research and development costs are expensed as incurred and include costs associated with research performed pursuant to collaborative agreements and government grants, including internal research. Research and development costs consist of direct and indirect internal costs related to specific projects, as well as fees paid to others that conduct certain research activities on the Company’s behalf.

 

Debt Extinguishment

 

The Company accounts for the income or loss from extinguishment of debt in accordance with ASC 470, Debt, which indicates that for all extinguishment of debt, the difference between the reacquisition consideration and the net carrying amount of the debt being extinguished should be recognized as gain or loss when the debt is extinguished. Losses from debt extinguishment are shown in the consolidated statements of operations under "Other income (expense)" as "Loss upon extinguishment of debt".

 

Stock-based Compensation

 

The Company accounts for stock-based employee compensation plans under the fair value recognition and measurement provisions of U.S. GAAP. Those provisions require all stock-based payments to employees, including grants of stock options and restricted stock units (RSUs), to be measured using the grant-date fair value of each award. The Company recognizes stock-based compensation expense net of expected forfeitures over each award's requisite service period, which is generally the vesting term. Expected forfeiture rates are estimated based on the Company's historical experience. Stock-based compensation plans are described more fully in Note 12, "Stock-based Compensation".

 

Income Taxes

 

The Company is subject to income taxes in the United States and foreign jurisdictions and uses estimates to determine its provisions for income taxes. The Company uses the asset and liability method of accounting for income taxes, whereby deferred tax asset or liability account balances are calculated at the balance sheet date using current tax laws and rates in effect for the year in which the differences are expected to affect taxable income.

 

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Recognition of deferred tax assets is appropriate when realization of such assets is more likely than not. The Company recognizes a valuation allowance against its net deferred tax assets unless it is more likely than not that such deferred tax assets will be realized. This assessment requires judgement as to the likelihood and amounts of future taxable income by tax jurisdiction.

 

The Company applies the provisions of Financial Accounting Standards Board (FASB) guidance on accounting for uncertainty in income taxes. The Company assesses all material positions taken in any income tax return, including all significant uncertain positions, in all tax years that are still subject to assessment or challenge by relevant taxing authorities. Assessing an uncertain tax position begins with the initial determination of the position’s sustainability, and the tax benefit to be recognized is measured at the largest amount of benefit that is greater than 50 percent likely of being realized upon ultimate settlement. As of each balance sheet date, unresolved uncertain tax positions must be reassessed, and the Company will determine whether (i) the factors underlying the sustainability assertion have changed and (ii) the amount of the recognized tax benefit is still appropriate. The recognition and measurement of tax benefits requires significant judgement, and such judgements may change as new information becomes available.

 

Foreign Currency Translation

 

The assets and liabilities of foreign subsidiaries, where the local currency is the functional currency, are translated from their respective functional currencies into U.S. dollars at the rates in effect at each balance sheet date, and revenue and expense amounts are translated at average rates during each period, with resulting foreign currency translation adjustments recorded in other comprehensive loss, net of tax, in the consolidated statements of stockholders’ deficit. As of December 31, 2018 and 2017, cumulative translation adjustment, net of tax, were $43.3 million and $42.2 million, respectively.

 

Where the U.S. dollar is the functional currency, remeasurement adjustments are recorded in other income (expense), net in the accompanying consolidated statements of operations. Net losses resulting from foreign exchange transactions were $1.6 million and $0.4 million for the years ended December 31, 2018 and 2017, respectively and are recorded in other income (expense), net in the consolidated statements of operations.

 

New Accounting Standards or Updates Recently Adopted

 

During the year ended December 31, 2018 the Company adopted the following Accounting Standards Updates (ASUs):

 

Revenue Recognition The Company adopted ASC 606, Revenue from Contracts with Customers, with a date of initial application of January 1, 2018. As a result, the Company has changed its accounting policy for revenue recognition as detailed above in “Significant Accounting Policies”. The Company applied ASC 606 using the modified retrospective approach by recognizing the cumulative effect of initially applying ASC 606 to all contracts not completed as of the date of adoption as an adjustment to the opening balance of accumulated deficit at January 1, 2018. Therefore, the comparative information has not been adjusted and continues to be reported under the legacy revenue recognition guidance of ASC 605, "Revenue Recognition".

 

The Company applied ASC 606 using a practical expedient for contracts that were modified before the application date, which allowed the Company to determine an aggregate effect of all modifications that occurred before January 1, 2018, when determining the satisfied and unsatisfied performance obligations, the transaction price, and allocating that transaction price to the performance obligations instead of retrospectively restating the contracts for such contract modifications.

 

The cumulative effect of initially applying ASC 606 resulted in an increase to accumulated deficit at January 1, 2018 of approximately $0.8 million. The most significant change in accounting policy is the Company is now required to estimate royalty revenues from licenses of the Company’s intellectual property and recognize estimated royalty revenues at a point in time when the Company sells its renewable products to its customers (if the sales-based royalty exception does not apply) or when the licensee sells its products to its customer (if the sales-based royalty exception does apply).

 

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The following table presents the amounts by which revenue is affected in the current reporting period by the application of ASC 606 as compared with the legacy guidance that was in effect before the accounting change.

 

   Year Ended December 31, 2018
(In thousands)  As Reported  Adjustments  Amounts Without the Adoption of ASC 606
Renewable products  $33,598   $   $33,598 
Licenses and royalties   7,658    5,094    12,752 
Grants and collaborations   22,348    (5,786)   16,562 
Total revenue from all customers  $63,604   $(692)  $62,912 

 

Financial Instruments In January 2016, the Financial Accounting Standards Board (FASB) issued ASU 2016-01, Financial Instruments-Overall (Subtopic 825-10): Recognition and Measurement of Financial Assets and Financial Liabilities, which changes the accounting for equity investments, financial liabilities under the fair value option, and the presentation and disclosure requirements for financial instruments. The Company adopted ASU 2016-01 on January 1, 2018. Adoption of this ASU did not impact the Company's consolidated financial position, results of operations or cash flows.

 

Classification of Cash Flow Elements In August 2016, the FASB issued ASU 2016-15, Statement of Cash Flows (Topic 230): Classification of Certain Cash Receipts and Cash Payments, which affects the classification of certain cash receipts and cash payments on the statement of cash flows. ASU 2016-15 results in a change in cash flow classification of debt prepayment or extinguishment costs. ASU 2016-15 became effective January 1, 2018 on a retrospective basis. Adoption of this ASU did not impact the Company's consolidated financial position, results of operations or cash flows.

 

Income Taxes Related to Intra-entity Asset Transfers In October 2016, FASB issued ASU 2016-16, Intra-Entity Transfers of Assets Other Than Inventory on simplifying the accounting for income taxes related to intra-entity asset transfers. The new guidance allows an entity to recognize the tax expense from the sale of an asset in the seller’s tax jurisdiction when the transfers occurs, even though the pre-tax effects of that transaction are eliminated in consolidation. ASU 2016-16 became effective January 1, 2018, which the Company adopted on a modified retrospective basis.

 

Restricted Cash in Statement of Cash Flows In November 2016, the FASB issued ASU 2016-18, Statement of Cash Flows (Topic 230): Restricted Cash, which requires that a statement of cash flows explain the change during the period in the total of cash, cash equivalents, and amounts generally described as restricted cash or restricted cash equivalents. Therefore, amounts generally described as restricted cash and restricted cash equivalents should be included with cash and cash equivalents when reconciling the beginning-of-period and end-of-period total amounts shown on the statement of cash flows. The accounting standard update became effective January 1, 2018 using a retrospective transition method for each period presented. Upon adoption, ASU 2016-18 resulted in a change in the presentation of restricted cash in the statement of cash flows for current and prior periods presented.

 

Derecognition of Nonfinancial Assets In February 2017, the FASB issued ASU 2017-05, Other Income—Gains and Losses from the Derecognition of Nonfinancial Assets (Subtopic 610-20): Clarifying the Scope of Asset Derecognition Guidance and Accounting for Partial Sales of Nonfinancial Assets, which requires entities to apply certain recognition and measurement principles in ASC 606 when they derecognize nonfinancial assets, and in substance, nonfinancial assets, and the counterparty is not a customer. The guidance applies to: (1) contracts to transfer to a noncustomer a nonfinancial asset or group of nonfinancial assets, or an ownership interest in a consolidated subsidiary that does not meet the definition of a business and is not a not-for-profit activity; and (2) contributions of nonfinancial assets that are not a business to a joint venture or other noncontrolled investee. The accounting standard update became effective January 1, 2018 on a modified retrospective basis. Adoption of this ASU did not impact the Company's consolidated financial position, results of operations or cash flows.

 

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Income Taxes In March 2018, FASB issued ASU 2018-05, Amendments to SEC Paragraphs Pursuant to SEC Staff Accounting Bulletin No. 118 to address the application of GAAP in situations when a registrant does not have the necessary information available, prepared or analyzed (including computations) in reasonable detail to complete the accounting for certain income tax effects of the Tax Act. As of December 31, 2018, the Company's analysis for the Transition Tax has been filed with its December 31, 2017 tax return and the Company considered its accounting for this area of the Tax Act to be complete as of such date and did not make any measurement-period adjustments related to it. In addition, the Company considered its accounting for changes in the U.S. federal rate and deferred tax impact for the rate change to be complete. The Company also accounted for the tax impact related to other areas of the Tax Act and believe its analysis to be completed consistent with the guidance in ASU 2018-05. The Company recognizes that the IRS is continuing to publish and finalize ongoing guidance with respect to the Act which may modify accounting interpretation for the Tax Act, the Company would look to account for these impacts in the period of such change is enacted.

 

Non-employee Stock-based Compensation In June 2018, the FASB issued ASU 2018-07, Improvements to Nonemployee Share-Based Payment Accounting, which more closely aligns the accounting for employee and nonemployee stock-based compensation. Under the new standard, companies are no longer required to value non-employee awards differently from employee awards. The Company adopted this accounting standard update on January 1, 2018 using a modified retrospective approach. Adoption of this ASU did not impact the Company's consolidated financial position, results of operations or cash flows.

 

Recent Accounting Standards or Updates Not Yet Effective

 

Leases In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842), as subsequently updated, with fundamental changes as to how entities account for leases. Lessees will need to recognize a right-of-use asset and a lease liability for virtually all of their leases (other than leases that meet the definition of a short-term lease). The liability will be equal to the present value of lease payments. The asset will be based on the liability, subject to adjustment, such as for initial direct costs. Additional disclosures for leases will also be required.

 

The Company is adopting the new standard effective January 1, 2019 using a modified retrospective method, and will not restate comparative periods. The modified retrospective transition approach requires lessees and lessors to recognize and measure existing leases at the date of initial application. The new standard provides a number of optional practical expedients in transition. The Company expects to elect the “package of practical expedients”, which permits it not to reassess under the new standard prior conclusions about lease identification, lease classification and initial direct costs.

 

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The adoption of this standard on January 1, 2019 is expected to have the effect of increasing assets and liabilities on the consolidated balance sheet by $25.7 million, but is not expected to have a material impact on the consolidated statements of operations or cash flows. The most significant impact relates to (i) the recognition of new Right of Use (ROU) assets and lease liabilities on the balance sheet for operating leases; and (ii) providing significant new disclosures about leasing activities. Upon adoption, the Company will recognize operating lease liabilities of $33.6 million, based on the present value of the remaining minimum rental payments under current leasing standards for existing operating leases. The Company will also recognize ROU assets of $29.7 million, which represents the operating lease liability adjusted for accrued rent.

 

Financial Instruments with "Down Round" Features In July 2017, the FASB issued ASU 2017-11, Earnings Per Share (Topic 260); Distinguishing Liabilities from Equity (Topic 480); Derivatives and Hedging (Topic 815): Accounting for Certain Financial Instruments with Down Round Features. The amendments of this ASU update the classification analysis of certain equity-linked financial instruments, or embedded features, with down round features, as well as clarify existing disclosure requirements for equity-classified instruments. When determining whether certain financial instruments should be classified as liabilities or equity instruments, a down round feature no longer precludes equity classification when assessing whether the instrument is indexed to an entity’s own stock. The accounting standard update will be effective beginning in the first quarter of fiscal year 2019 using a modified retrospective approach. The Company completed its assessment of the new standard and determined the impact to the consolidated balance sheet would be material. The Company anticipates recording a $41.0 million reduction to derivative liabilities and a corresponding $41.0 million increase to equity on January 1, 2019.

 

Fair Value Measurement In August 2018, the FASB issued ASU 2018-13, Fair Value Measurement (Topic 820): Disclosure Framework—Changes to the Disclosure Requirements for Fair Value Measurement, which amends ASC 820, Fair Value Measurement. ASU 2018-13 modifies the disclosure requirements for fair value measurements by removing, modifying or adding certain disclosures. The accounting standard update will be effective beginning in the first quarter of fiscal year 2020, with removed and modified disclosures to be adopted on a retrospective basis, and new disclosures to be adopted on a prospective basis. The Company is in the initial stages of evaluating the impact of the new standard on its consolidated financial statements.

 

Collaborative Revenue Arrangements In November 2018, the FASB issued ASU 2018-18, Clarifying the Interaction between Topic 808 and Topic 606, that clarifies the interaction between the guidance for certain collaborative arrangements and Topic 606, the new revenue recognition standard. A collaborative arrangement is a contractual arrangement under which two or more parties actively participate in a joint operating activity and are exposed to significant risks and rewards that depend on the activity’s commercial success. The ASU provides guidance on how to assess whether certain transactions between collaborative arrangement participants should be accounted for within the revenue recognition standard. The accounting standard update will be effective beginning in the first quarter of fiscal year 2020 retroactively. The Company does not believe that the impact of the new standard on its consolidated financial statements will be material.

 

Credit Losses In June 2016, the FASB issued ASU 2016-13, Financial Instruments—Credit Losses (Topic 326), Measurement of Credit Losses on Financial Instruments. ASU 2016-13 requires entities to measure all expected credit losses for most financial assets held at the reporting date based on an expected loss model which includes historical experience, current conditions, and reasonable and supportable forecasts. Entities will now use forward-looking information to better form their credit loss estimates. ASU 2016-13 also requires enhanced disclosures to help financial statement users better understand significant estimates and judgments used in estimating credit losses, as well as the credit quality and underwriting standards of an entity's portfolio. ASU 2016-13 will become effective for the Company beginning in the first quarter of fiscal year 2020. The Company does not believe that the impact of the new standard on its consolidated financial statements will be material.

 

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2. Restatement of Consolidated Financial Statements

 

Restatement Background

 

Subsequent to the issuance of the Company's unaudited condensed consolidated financial statements as of September 30, 2018 and as previously announced on April 5, 2019 and May 14, 2019, the Audit Committee (the Audit Committee) of the Board of Directors of the Company (the Board) and the Board, respectively, concluded that the Company will restate its interim condensed consolidated financial statements for the quarterly and year-to-date periods ended March 31, 2018, June 30, 2018 and September 30, 2018 (collectively, the Restated 2018 Non-Reliance Periods) and its audited consolidated financial statements for the year ended December 31, 2017 (the Restated 2017 Non-Reliance Consolidated Financial Statements).

 

Restated 2017 Non-Reliance Consolidated Financial Statements

 

During the course of the re-audit of the Restated 2017 Financial Statements, in addition to incorrectly accounting for certain payment obligations under the Ginkgo Partnership Agreement as previously disclosed, the Company identified other accounting and financial reporting errors related to (i) the recognition of certain deemed dividends to preferred stock holders, (ii) incorrect accounting treatment for the derecognition of certain debt and derivative liability instruments, (iii) errors in computing tax expense, (iv) incorrect revenue recognition for certain non-cash consideration received under a collaboration agreement, (v) the timing of certain revenue recognition between quarters within 2017, (vi) computation of earnings (loss) per share, (vii) correction of errors in cash flow statements for non-cash adjustments, and (viii) computation of loss on extinguishment of certain debt instruments.

 

The error corrections for the year to date audited 2017 consolidated financial statements have been reflected throughout these consolidated financial statements and accompanying notes. Also, the tables below show the impact of each adjustment by the individual financial statement line item caption and provide a brief description of the adjustment.

 

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Consolidated Balance Sheet

 

The following table presents the Company's consolidated balance sheet at December 31, 2017 as previously reported, restatement adjustments and as restated (in thousands):

   December 31, 2017 
(In thousands)  As Previously Reported   Corrections   Ref.  As Restated 
Assets               
Current assets:                  
Cash and cash equivalents  $57,059   $—        $57,059 
Restricted cash   2,994    —         2,994 
Accounts receivable, net   24,281    (5,328)  a   18,953 
Accounts receivable - related party, net   9,340    (4,573)  a   4,767 
Accounts receivable, unbilled - related party       9,901        9,901 
Inventories   5,408    —         5,408 
Prepaid expenses and other current assets   5,525    (606)  b   4,919 
Total current assets   104,607    (606)      104,001 
Property, plant and equipment, net   13,892    —         13,892 
Accounts receivable, unbilled, noncurrent – related party   7,940    —         7,940 
Restricted cash, noncurrent   959    —         959 
Recoverable taxes from Brazilian government entities   1,445    —         1,445 
Other assets   22,640    (10,081)  c   12,559 
Total assets  $151,483   $(10,687)     $140,796 
Liabilities, Mezzanine Equity and Stockholders' Deficit                  
Current liabilities:                  
Accounts payable  $15,921   $(406)  d  $15,515 
Accrued and other current liabilities   29,402    (200)  e   29,202 
Contract liabilities   4,880    (572)  f   4,308 
Debt, current portion   36,924    —         36,924 
Related party debt, current portion   20,019    —         20,019 
Total current liabilities   107,146    (1,178)      105,968 
Long-term debt, net of current portion   61,893    (1,673)  g   60,220 
Related party debt, net of current portion   46,541    —         46,541 
Derivative liabilities   119,978    (3,481)  h   116,497 
Other noncurrent liabilities   10,632    13,026   i   23,658 
Total liabilities   346,190    6,694       352,884 
Commitments and contingencies                  
Mezzanine equity:                  
Contingently redeemable common stock   5,000    —         5,000 
Stockholders’ deficit:                  
Preferred stock   —      —         —   
Common stock - $0.0001 par value   5    —         5 
Additional paid-in capital   1,048,274    66,272   j   1,114,546 
Accumulated other comprehensive loss   (42,156)   —         (42,156)
Accumulated deficit   (1,206,767)   (83,653)  k   (1,290,420)
Total Amyris, Inc. stockholders’ deficit   (200,644)   (17,381)      (218,025)
Noncontrolling interest   937    —         937 
Total stockholders' deficit   (199,707)   (17,381)      (217,088)
Total liabilities, mezzanine equity and stockholders' deficit  $151,483   $(10,687)     $140,796 

 

Restatement adjustments:

a. Reclassification of related party accounts receivable to a separate line on the balance sheet.

b. Write-off of unrecoverable receivable in connection with facilities subleased to a related party.

c. Correction of error in recording amounts payable under Ginkgo Partnership Agreement as prepaid royalties instead of reduction in revenue.

d. Adjustment to uninvoiced receipts liability.

e. Adjustment to accrued liability.

f. Revision to accounting for equity received in satisfaction of a customer receivable.

g. Adjustment to issuance-date fair value of a debt instrument.

h. Make-whole derivative liabilities adjustment.

i. Accrual of the Ginkgo Partnership Payments obligation, net of reduction to deferred revenue liability.

j. Correction to the accounting for a make-whole equity instrument in connection with May 2017 equity offering.

k. Sum of adjustments to net loss for the year ended December 31, 2017 as result of corrections.

 

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Consolidated Statement of Operations

 

The following table presents the Company's consolidated statements of operations for the year ended December 31, 2017 as previously reported, restatement adjustments and as restated (in thousands, except per share amounts):

 

  Year Ended
December 31, 2017
(In thousands, except shares and per share amounts)  As Previously Reported  Reclassifications(1)  Corrections  Ref  As Restated
                
                
Renewable products  $45,781   $(3,411)  $      $42,370 
Licenses and royalties   57,703    6,774    (15,774)  ab   48,703 
Grants and collaborations   39,960    (3,363)   1      36,598 
Total revenue   143,444        (15,773)      127,671 
Cost and operating expenses                      
Cost of products sold   62,713        (406)  ad   62,307 
Research and development   57,027    (72)   607   ae   57,562 
Sales, general and administrative   63,219    72    562   af   63,853 
Total cost and operating expenses   182,959        763       183,722 
Loss from operations   (39,515)       (16,536)      (56,051)
Other income (expense)                       
(Loss) gain on divestiture   5,732               5,732 
Interest expense   (34,033)       (3,048)  ah   (37,081)
(Loss) gain from change in fair value of derivative instruments   (1,742)       (47,110)  ai   (48,852)
Loss upon extinguishment of debt   (1,521)       (10,376)  ak   (11,897)
Other income (expense), net   (955)       (1)      (956)
Total other expense, net   (32,519)       (60,535)      (93,054)
Loss before income taxes   (72,034)       (77,071)      (149,105)
Provision for income taxes   (295)       (6,582)  am   (6,877)
Net loss attributable to Amyris, Inc.   (72,329)       (83,653)      (155,982)
Less deemed dividend on capital distribution to related parties   (8,648)       8,648   an    
Less deemed dividend related to beneficial conversion feature on Series A preferred stock   (562)              (562)
Less deemed dividend related to beneficial conversion feature on Series B preferred stock   (634)              (634)
Less deemed dividend related to beneficial conversion feature on Series D preferred stock   (5,757)              (5,757)
Less deemed dividend upon settlement of make-whole provision on Series A preferred stock           (10,505)  ap   (10,505)
Less deemed dividend upon settlement of make-whole provision on Series B preferred stock           (22,632)  aq   (22,632)
Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series A preferred stock           (21,578)  ar   (21,578)
Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series B preferred stock           (24,366)  as   (24,366)
Less cumulative dividends on Series A and Series B preferred stock   (5,439)       5,439   aw    
Add: losses allocated to participating securities           40,159   au   40,159 
Net loss attributable to Amyris, Inc. common stockholders  $(93,369)      $(108,488)     $(201,857)
                        
Net loss per share attributable to common stockholders                       
Basic and diluted  $(2.89)               $(6.26)
Weighted-average shares of common stock outstanding used in computing loss per share of common stock:                       
Basic and diluted   32,253,570                 32,253,570 

 

(1) Reclassification of revenue and operating expense by type to conform to the Company's current presentation.

 

Restatement adjustments:

ab. Ginkgo partnership obligation and promissory note issuance recorded as reduction to revenue and correction of errors in recording revenue from non-cash consideration.

ad. Correction in connection with a sales return, and adjustment to uninvoiced receipts liability.

ae. Write-off of unrecoverable receivable in connection with facilities subleased to a related party, and reclassification of operating expense by classification to conform to the Company's current presentation.

af. Expense incurred in connection with May 2017 equity offering.

ah. Correction to amortization of debt discounts, and interest expense in connection with partnership payments obligation.

ai. Correction to accounting for make-whole liability in connection with May 2017 Offering.

ak. Loss on extinguishment of related and unrelated party debt.

am. Tax provision to accrue liability for unrecognized tax benefit.

an. Loss on extinguishment of related and unrelated party debt.

ap. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings.

aq. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings.

ar. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings.

as. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings.

au. Correction in the computation of loss per share to reflect participating securities.

aw. Correction in the computation of net loss per share related to make-whole deemed dividends.

 

 

 

 26 

 

 

Consolidated Statement of Cash Flows

 

The following table presents the Company's consolidated statements of cash flows for the year ended December 31, 2017 as previously reported, restatement adjustments and as restated (in thousands). In this table, As Restated amounts reflect the impact of corrections to the consolidated balance sheet as of December 31, 2017 and the statement of operations for the year ended December 31, 2017, as well as the Company's adoption of ASU 2016-18, which changes how restricted cash is reported in statements of cash flows.

 

    Year Ended December 31, 2017
(In thousands)   As Previously Reported   Corrections(1)   As Restated
             
Operating activities                        
Net loss   $ (72,329 )     (83,653 )   $ (155,982 )
Adjustments to reconcile net loss to net cash used in operating activities:                        
Depreciation and amortization     11,358             11,358  
(Gain) loss on disposal of property, plant and equipment     142             142  
Stock-based compensation     6,265             6,265  
Amortization of debt discount     12,490       2,749       15,239  
(Gain) loss upon extinguishment of debt     1,521       10,376       11,897  
Receipt of equity in connection with collaboration arrangements revenue     (2,661 )     2,661        
(Gain) loss from change in fair value of derivative liabilities     1,742       47,110       48,852  
(Gain) loss on foreign currency exchange rates     (1,230 )           (1,230 )
Noncash revenue reduction related to issuance of debt obligations           13,413       13,413  
Non-cash gain on divestiture     (5,732 )           (5,732 )
Receipt of noncash consideration in connection with license revenue     (8,046 )           (8,046 )
Changes in assets and liabilities:                        
Accounts receivable     (19,647 )           (19,647 )

Accounts receivable, unbilled – related party

    (7,940 )           (7,940 )
Inventories     (3,126 )           (3,126 )
Prepaid expenses and other assets     (19,336 )     606       (18,730 )
Accounts payable     5,858       (406 )     5,452  
Accrued and other liabilities     7,295       6,582       13,877  
Contract liabilities     (7,241 )           (7,241 )
Net cash used in operating activities     (100,617 )     (562 )     (101,179 )
Investing activities                        
Proceeds from divestiture     54,827             54,827  
Change in short-term investments     712       581       1,293  
Change in restricted cash     865       (865 )      
Purchases of property, plant and equipment     (4,412 )           (4,412 )
Net cash (used in) provided by investing activities     51,992       (284 )     51,708  
Financing activities                        
Proceeds from issuance of convertible preferred stock     101,124       (2,878 )     98,246  
Proceeds from exercises of common stock options     160       (160 )      
Payment of minimum employee taxes withheld upon net share settlement of restricted stock units     (385 )           (385 )
Proceeds from issuance of common stock in August 2017 offering           5,759       5,759  
Issuance costs incurred           (2,159 )     (2,159 )
Change in restricted cash related to contingently redeemable common stock     1,046       (1,046 )      
Proceeds from issuance of debt, net of issuance costs     18,925             18,925  
Principal payments on debt     (37,500 )           (37,500 )
Payment of swap termination     (3,113 )           (3,113 )
Payment on early redemption of debt     (1,909 )           (1,909 )
Net cash provided by financing activities     78,348       (484 )     77,864  
Effect of exchange rate changes on cash, cash equivalents and restricted cash     186             186  
Net (decrease) increase in cash, cash equivalents and restricted cash     29,909       (1,330 )     28,579  
Cash, cash equivalents and restricted cash at beginning of year     27,150       5,283       32,433  
Cash, cash equivalents and restricted cash at end of year   $ 57,059       3,953       61,012  
                         
Reconciliation of cash, cash equivalents and restricted cash to the consolidated balance sheets                        
Cash and cash equivalents                   $ 57,059  
Restricted cash, current                     2,994  
Restricted cash, noncurrent                     959  
Total cash, cash equivalents and restricted cash                   $ 61,012  
                         
Supplemental disclosures of cash flow information:                        
Cash paid for interest   $ 11,539     $     $ 11,539  
Supplemental disclosures of non-cash investing and financing activities:                        
Issuance of common stock upon conversion of debt   $ 28,702     $     $ 28,702  
Accrued interest added to debt principal   $ 2,816     $     $ 2,816  
Issuance of common stock for settlement of debt principal and interest payments   $ 3,436     $     $ 3,436  
Financing of insurance premium under note payable   $ 467     $     $ 467  
Issuance of convertible preferred stock upon conversion of debt   $ 40,204     $     $ 40,204  
Settlement of debt principal by a related party   $ 25,000     $     $ 25,000  
Issuance of note payable in exchange for debt extinguishment with third party   $ 16,954     $     $ 16,954  
Issuance of common stock for settlement of debt   $ 10,708     $     $ 10,708  
Issuance of preferred stock attributed to derivative liabilities   $     $ 72,725     $ 72,725  

 

(1) To reflect the impact of restatement corrections on the statement of cash flows.

 

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3. Balance Sheet Details

 

Allowance for Doubtful Accounts 

 

Allowance for doubtful accounts activity and balances were as follows:

 

(In thousands)   Balance at
Beginning of Year
  Provisions   Recoveries
(Write-offs), Net
  Balance at
End of Year
Allowance for doubtful accounts:                                
Year Ended December 31, 2018   $ 642     $     $     $ 642  
Year Ended December 31, 2017 (as restated, Note 2)   $ 501     $ 141     $     $ 642  

 

Inventories

 

December 31,
(In thousands)
  2018   2017
            (As Restated, Note 2)
Raw materials   $ 3,901     $ 819  
Work in process     539       364  
Finished goods     5,253       4,225  
Total inventories   $ 9,693     $ 5,408  

 

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Prepaid expenses and other current assets

 

December 31,
(In thousands)
  2018   2017
            (As Restated, Note 2)
Prepayments, advances and deposits   $ 5,644     $ 3,599  
Recoverable taxes from Brazilian government entities     631       87  
Other     4,291       1,233  
Total prepaid expenses and other current assets   $ 10,566     $ 4,919  

 

Property, plant and equipment, net

 

December 31,
(In thousands)
  2018   2017
        (As Restated, Note 2)
Machinery and equipment   $ 43,713     $ 46,317  
Leasehold improvements     39,922       40,036  
Computers and software     9,987       9,555  
Furniture and office equipment, vehicles and land     3,016       3,415  
Construction in progress     1,749       2,838  
Total property, plant and equipment, gross     98,387       102,161  
Less: accumulated depreciation and amortization     (78,631 )     (88,269 )
Total property, plant and equipment, net   $ 19,756     $ 13,892  

 

Property, plant and equipment, net includes $5.0 million and $4.2 million of machinery and equipment under capital leases as of December 31, 2018 and 2017, respectively. Accumulated amortization of assets under capital lease totaled $2.3 million and $1.6 million as of December 31, 2018 and 2017, respectively.

 

Depreciation and amortization expense, including amortization of assets under capital leases, was $4.9 million and $11.4 million for the years ended December 31, 2018 and 2017, respectively.

 

Losses on disposal of property, plant and equipment were $0.9 million and $0.1 million for the years ended December 31, 2018 and 2017, respectively. Such losses or gains were included in "Research and development" expense in the consolidated statements of operations.

 

In December 2017, the Company's sold its Brotas production plant in Brazil to a unit of DSM Nutritional Products Ltd (together with its affiliates, DSM); see Note 13, "Divestiture" and Note 11, "Related Party Transactions" for details.

 

Other assets

 

December 31,
(In thousands)
  2018   2017
        (As Restated, Note 2)
Contingent consideration   $ 4,286     $ 8,150  
Deposits     2,465       2,462  
Other     1,207       1,947  
Total other assets   $ 7,958     $ 12,559  

 

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Accrued and other current liabilities

 

December 31,
(In thousands)
  2018   2017
            (As Restated, Note 2)
Payroll and related expenses   $ 9,220     $ 7,238  
Contract termination fees     4,092        
Accrued interest     3,853       8,213  
Asset retirement obligation(1)     3,063       3,587  
Ginkgo partnership payments obligation     2,155        
Tax-related liabilities     2,139       5,837  
Professional services     1,173       1,694  
Other     3,284       2,633  
Total accrued and other current liabilities   $ 28,979     $ 29,202  

 

______________

  (1) The asset retirement obligation represents liabilities incurred but not yet discharged in connection with our 2013 abandonment of a partially constructed facility in Pradópolis, Brazil.

 

Other noncurrent liabilities

 

December 31,
(In thousands)
  2018   2017
        (As Restated, Note 2)
Liability for unrecognized tax benefit   $ 6,582     $ 6,582  
Deferred rent, net of current portion     6,440       7,818  
Ginkgo partnership payments obligation, net of current portion     6,185       6,444  
Contract liabilities, net of current portion     1,587       383  
Contract termination fees, net of current portion(1)     1,530        
Capital leases, net of current portion     195       217  
Other     673       2,214  
Total other noncurrent liabilities   $ 23,192     $ 23,658  

______________

  (1) Contract liabilities, net of current portion at December 31, 2018 and 2017 includes $1,204 and $383 in connection with DSM, which is a related party.

 

In November 2017, the Company entered into a partnership agreement with one of its former collaboration partners, Ginkgo Bioworks, Inc. and has an obligation to make quarterly payments of $0.8 million from December 31, 2018 through September 2022. At December 31, 2018, total future minimum payments under the agreement totaled $12.7 million. The Company recorded this liability at its discounted present value of $6.1 million and is accreting the $6.6 million discount to interest expense over the five-year repayment period. Also, in conjunction with the partnership agreement, the Company issued a $12.0 million promissory note, which is included in long-term debt at a $8.0 million carrying value, net of unamortized discount. See Note 10, “Revenue Recognition” for information regarding the Ginkgo Partnership Agreement and the related accounting treatment for the partnership payments.

 

In September 2019, the Company was notified by DSM that certain contingent consideration payable to the Company upon the realization of certain NOL tax benefits transferred to DSM with the sale of the Brotas facility in December 2017 would not be realized due to changes in DSM’s Brazilian legal entity structure. The Company considered this information in conjunction with the probability and timing of DSM’s realization of the underlying NOL tax benefits and determined that $3.9 million of the contingent consideration receivable was not recoverable as of December 31, 2018.

 

4. Fair Value Measurement

 

Assets and liabilities are measured and reported at fair value per related accounting standards that define fair value as the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. The fair value hierarchy prioritizes the inputs to valuation techniques used to measure fair value. An asset's or liability's level is based on the lowest level of input that is significant to the fair value measurement. Assets and liabilities carried at fair value are valued and disclosed in one of the following three levels of the valuation hierarchy:

 

     Level 1: Quoted market prices in active markets for identical assets or liabilities.

     Level 2: Observable market-based inputs or unobservable inputs that are corroborated by market data.

     Level 3: Unobservable inputs that are not corroborated by market data.

 

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Assets and Liabilities Measured and Recorded at Fair Value on a Recurring Basis

 

As of December 31, 2018 and 2017, the Company’s financial assets and financial liabilities measured at fair value on a recurring basis were classified within the fair value hierarchy as follows:

 

December 31,
(In thousands)
  2018  2017 (As Restated, Note 2)
   Level 1  Level 2  Level 3  Total  Level 1  Level 2  Level 3  Total
Assets                        
Money market funds  $       $   $   $53,199   $   $   $53,199 
Certificates of deposit                       4,153        4,153 
Total assets measured and recorded at fair value  $       $   $   $53,199   $4,153   $   $57,352 
Liabilities                                        
6% Convertible Notes Due 2021  $       $57,918   $57,918   $   $   $   $ 
Embedded derivatives in connection with the issuance of debt and equity instruments                           723    723 
Freestanding derivative instruments in connection with the issuance of equity instruments           42,796    42,796            115,774    115,774 
Total liabilities measured and recorded at fair value  $   $   $100,714   $100,714   $   $   $116,497   $116,497 

 

There were no transfers between the levels during 2018 or 2017.

 

The Company’s assessment of the significance of a particular input to the fair value measurement in its entirety requires management to make judgements and consider factors specific to the asset or liability. The fair values of money market funds and certificates of deposit are based on fair values of identical assets. The method of determining the fair value of compound embedded derivative liabilities is described subsequently in this note. Market risk associated with compound embedded derivative liabilities relates to the potential reduction in fair value and negative impact to future earnings from a decrease in interest rates.

 

At December 31, 2018 and December 31, 2017, the carrying value of certain financial instruments, such as cash equivalents, accounts receivable, prepaid expenses and other current assets, accounts payable and other current accrued liabilities, approximate fair value due to their relatively short maturities and low market interest rates, if applicable.

 

Changes in fair value of derivative liabilities are presented as gains or losses in the consolidated statements of operations in the line captioned "Gain (loss) from change in fair value of derivative instruments".

 

Changes in the fair value of debt that is accounted for at fair value are presented as gains or losses in the consolidated statements of operations in the line captioned "Gain (loss) from change in fair value of debt".

 

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6% Convertible Notes Due 2021

 

The Company issued $60.0 million of 6% Convertible Notes Due 2021 on December 10, 2018 (see Note 5, "Debt" and “Subsequent Events” for details) and elected the fair value option of accounting for this instrument. At December 31, 2018, outstanding principal was $60.0 million, and the fair value was $57.9 million, which was measured using a binomial lattice model and assuming a 25.2% discount yield, 45% equity volatility, 50% / 50% probability of principal repayment in cash / stock, and 5% probability of change in control. The Company assumed that if a change of control event were to occur, it would occur at the end of the calendar year. See Note 5, “Debt” and Part II, Item 8, “Subsequent Events” for further information related to this debt instrument. For the year ended December 31, 2018, the Company recorded a $2.1 million gain from change in fair value of debt in connection with the 6% Convertible Notes Due 2021, as follows:

 

In thousands    
Fair value at issuance on December 10, 2018   $ 60,000  
Change in fair value     (2,082 )
Fair value at December 31, 2018   $ 57,918  

 

Derivative Instruments

 

Derivative instruments measured at fair value on a recurring basis as of December 31, 2018 and 2017 are as follows:

 

December 31,
(In thousands)
  2018   2017
        (As Restated, Note 2)
Equity-related derivative liabilities   $ 41,272     $ 108,887  
Debt-related derivative liabilities     1,524       7,610  
Total derivative liabilities   $ 42,796     $ 116,497  

 

The following table provides a reconciliation of the beginning and ending liability balances associated with derivative liabilities – either freestanding or compound embedded – measured at fair value using significant unobservable inputs (Level 3):

 

 

(in thousands)   2018   2017
        (As Restated, Note 2)
Balance at January 1   $ 116,497     $ 4,135  
Additions     4,089       133,517  
Loss from change in fair value of derivative liabilities     30,880       48,852  
Derecognition to additional paid-in capital upon conversion or extinguishment     (108,670 )     (70,007 )
Balance at December 31   $ 42,796     $ 116,497  

 

The liabilities associated with freestanding and compound embedded derivatives represent the fair value of the equity conversion options, make-whole provisions, down round conversion price or conversion rate adjustment provisions and antidilution provisions in some of the Company's debt, preferred stock, cash warrants and antidilution warrants; see Note 5, "Debt", and Note 7, "Stockholders' Deficit". There is no current observable market for these types of derivatives and, as such, the Company determined the fair value of the freestanding or embedded derivatives using the Monte Carlo or binomial lattice models.

 

A binomial lattice model was used to determine if a convertible note or share of convertible preferred stock would be converted, called or held at each decision point. Within the lattice model, the following assumptions are made: (i) the convertible note or share of convertible preferred stock will be converted early if the conversion value is greater than the holding value and (ii) the convertible note or share of convertible preferred stock will be called if the holding value is greater than both (a) redemption price and (b) the conversion value at the time. If the convertible note or share of convertible preferred stock is called, the holder will maximize their value by finding the optimal decision between (1) redeeming at the redemption price and (2) converting the convertible note or share of convertible preferred stock. Using this lattice method, the Company valued the embedded and freestanding derivatives using the "with-and-without method", where the fair value of each related convertible note or share of convertible preferred stock including the embedded derivative is defined as the "with", and the fair value of the convertible note excluding the embedded derivatives is defined as the "without". This method estimates the fair value of the embedded and freestanding derivatives by looking at the difference in the values between each convertible note or share of convertible preferred stock with the embedded and freestanding derivatives and the fair value of such convertible note or share of convertible preferred stock without the embedded and freestanding derivatives. The lattice model uses the stock price, conversion price, maturity date, risk-free interest rate, estimated stock volatility and estimated credit spread. The Company marks the compound embedded derivatives to market due to the conversion price not being indexed to the Company's own stock.

 

 32 

 

 

The Company used a Monte Carlo simulation valuation model to determine the fair value of the May 2017 and August 2017 Cash and Dilution Warrants. Monte Carlo simulation combines a random number generator based on a probability distribution and additional inputs of volatility, time to expiration to generate a stock price and other uncertainties. The generated stock price at the time of expiration is then used to calculate the value of the option. The model then calculates results tens of thousands of times, each time using a different set of random values from the probability functions. The resulting Monte Carlo simulation valuation is based on the average of all the calculated results.

 

The market-based assumptions and estimates used in valuing the compound embedded and freestanding derivative liabilities include amounts in the following ranges/amounts:

 

December 31,   2018   2017
Risk-free interest rate   2.5% - 3.0%   1.7% - 2.4%
Risk-adjusted discount yield   17.2% - 27.3%   18.4% - 28.5%
Stock price volatility   45.0% - 85.0%   45.0% - 80.0%
Probability of change in control     0.0%       5.0%  
Stock price     $3.34       $3.75  
Credit spread   14.6% - 24.9%   16.6% - 26.7%
Estimated conversion dates   2019 - 2025   2018 - 2025

 

Changes in valuation assumptions can have a significant impact on the valuation of the embedded and freestanding derivative liabilities and debt that the Company elects to account for at fair value. For example, all other things being equal, a decrease/increase in the Company’s stock price, probability of change of control, credit spread, term to maturity/conversion or stock price volatility decreases/increases the valuation of the liabilities, whereas a decrease/increase in risk adjusted yields or risk-free interest rates increases/decreases the valuation of the liabilities. Certain of the convertible notes, shares of convertible preferred stock and warrants also include conversion or exercise price adjustment features and, for example, certain issuances of common stock by the Company at prices lower than the current conversion or exercise price result in a reduction of the conversion price of such notes or convertible preferred stock, or a reduction in the exercise price of, or an increase in the number of shares subject to, such warrants, which increases the value of the embedded and freestanding derivative liabilities and debt measured at fair value; see Note 5, "Debt" for details.

 

The Series A Preferred Stock issued in May 2017 and Series B Preferred Stock issued in May 2017 (see Note 7, “Stockholder’s Deficit”) included make-whole provisions, which are accounted for as embedded derivatives through the July 2017 Shareholder Approval date at which time the make-whole provision became settleable for a fixed number of common stock shares and ceased to be accounted for as a derivative liability. Cash and antidilution warrants, classified as freestanding financial instruments, were also issued in conjunction with the May 2017 Offering, August 2017 DSM Offering and August 2017 Vivo Offering and are classified as derivative liabilities. The total derivative liability recorded for the securities issued in connection with the May 2017 Offering, August 2017 DSM Offering and August 2017 Vivo Offering was $113.1 million.

 

In June 2012, the Company entered into a cross-currency interest rate swap arrangement with Banco Pine with respect to the repayment of R$22.0 million (approximately U.S. $6.6 million based on the exchange rate as of December 31, 2017) of the Banco Pine Note. The swap arrangement exchanged the principal and interest payments under the Banco Pine Note (see Note 4, "Debt") for alternative principal and interest payments that are subject to adjustment based on fluctuations in the foreign currency exchange rate between the U.S. dollar and Brazilian real. The swap had a fixed interest rate of 3.94%. Changes in the fair value of the swap were recognized in the consolidated statements of operations, in “Gain (loss) from change in fair value of derivative instruments". As of December 31, 2017, the balances of the loan and the associated cross-currency interest rate swap were zero.

 

Assets and Liabilities Recorded at Carrying Value

 

Financial Assets and Liabilities

 

The carrying amounts of certain financial instruments, such as cash equivalents, accounts receivable, accounts payable and accrued liabilities, approximate fair value due to their relatively short maturities and low market interest rates, if applicable. Loans payable, credit facilities and convertible notes are recorded at carrying value (except for the 6% Convertible Notes Due 2021, which are recorded at fair value), which is representative of fair value at the date of acquisition. For loans payable and credit facilities recorded at carrying value, the Company estimates fair value using observable market-based inputs (Level 2); for convertible notes, the Company estimates fair value based on rates currently offered for instruments with similar maturities and terms (Level 3). The carrying amount (the total amount of net debt presented on the balance sheet) of the Company's debt at December 31, 2018, excluding the 6% Convertible Notes that the Company records at fair value, and at December 31, 2017, was $151.7 million and $165.4 million, respectively. The fair value of such debt at December 31, 2018 and at December 31, 2017 was $149.3 million and $156.9 million, respectively, and was determined by (i) discounting expected cash flows using current market discount rates estimated for certain of the debt instruments and (ii) using third-party fair value estimates for the remaining debt instruments.

 

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Assets and Liabilities Measured and Recorded at Fair Value on a Non-Recurring Basis

 

On November 19, 2018, the Company amended its supply agreement with DSM, as discussed in Note 10, “Revenue Recognition” to secure production capacity at the Brotas facility in exchange for future cash payments totaling $22.7 million, the issuance of 1,643,991 million shares common stock valued at $6.1 million on the date of issuance and a further cash payment for the difference between the fair value of the common stock and $7.3 million on March 29, 2019. In addition, the Company modified certain warrants held by DSM which resulted in the transfer of $2.9 million of value to DSM and paid $1.8 million to settle certain obligations to DSM related to the 2017 sale of the Brotas facility. The Company also entered into other transactions contemporaneously with the amended supply agreement as discussed in Note 11, “Related Party Transactions” and Note 16, “Subsequent Events”. This series of transactions with DSM in November 2018 was accounted for as a combined transaction in which the Company determined and allocated the fair value of the consideration to each element. The fair value of the consideration transferred to DSM under the combined arrangement totaled $33.3 million and was allocated as follows (in thousands):

 

Element   Fair Value Allocation
Manufacturing capacity reservation fee   $ 24,395  
Legal settlement and consent waiver     6,764  
Working capital adjustment     2,145  
Total fair value of consideration transferred   $ 33,304  

 

The fair value of these elements is based on Level 3 inputs, which considered the lowest level of input that is significant to the fair value measurement of these elements. To determine the fair value of the manufacturing capacity reservation fee, the Company used a discounted cash flow model under a cost savings valuation approach based on a competing manufacturing quote for similar capacity, location and timing. The Company used a discount rate of 22.5% and a tax rate of 0% to discount the gross cash flows. The fair value of the legal settlement for failure to obtain consent from DSM prior to executing the August 2018 Vivo Warrant transaction and was determined by calculating the difference between the fair values of the warrants held by Vivo prior to and after the August 2018 Vivo Warrant transaction using a combination of a Monte Carlo simulation and the Black-Scholes-Merton option pricing model. The fair value of the working capital adjustment was determined to equal the difference between the preliminary estimate for working capital upon closing the Brotas facility sale and the final working capital amounts transferred.

 

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5. Debt

 

December 31,
(In thousands)
  2018   2017
    Principal   Unamortized
Debt
(Discount)
Premium
  Change in
Fair Value
  Net   Principal   Unamortized
Debt
(Discount)
Premium
  Net
Convertible notes payable                                           (As Restated, Note 2)        
6% convertible notes due 2021   $ 60,000     $     $ (2,082 )   $ 57,918     $     $     $  
2015 Rule 144A convertible notes     37,887       (2,413 )           35,474       37,887       (9,458 )     28,429  
2014 Rule 144A convertible notes     24,004       (867 )           23,137       24,004       (3,170 )     20,834  
August 2013 financing convertible notes     4,415       (70 )           4,345       4,009       (2,126 )     1,883  
December 2017 convertible notes                             5,000       (25 )     4,975  
      126,306       (3,350 )     (2,082 )     120,874       70,900       (14,779 )     56,121  
Related party convertible notes payable                                                        
2014 Rule 144A convertible notes     24,705       (1,038 )           23,667       24,705       (3,784 )     20,921  
August 2013 financing convertible notes                             21,711       897       22,608  
R&D note                             3,700       (18 )     3,682  
      24,705       (1,038 )           23,667       50,116       (2,905 )     47,211  
Loans payable and credit facilities                                                        
GACP term loan facility     36,000       (1,349 )           34,651                    
Ginkgo note     12,000       (4,047 )           7,953       12,000       (4,862 )     7,138  
Other loans payable     4,910       (1,047 )           3,863       6,463       (1,277 )     5,186  
Senior secured loan facility                             28,566       (253 )     28,313  
Other credit facilities                             381             381  
      52,910       (6,443 )           46,467       47,410       (6,392 )     41,018  
Related party loans payable                                                        
DSM note     25,000       (6,311 )           18,689       25,000       (8,039 )     16,961  
February 2016 private placement                             2,000             2,000  
Other DSM loan                             393             393  
      25,000       (6,311 )           18,689       27,393       (8,039 )     19,354  
Total debt   $ 228,921     $ (17,142 )   $ (2,082 )     209,697     $ 195,819     $ (32,115 )     163,704  
Less: current portion                             (147,677 )                     (56,943 )
Long-term debt, net of current portion                           $ 62,020                     $ 106,761  

 

Future minimum payments under the debt agreements as of December 31, 2018 are as follows:

 

Years ending December 31
(In thousands)
  Convertible Notes   Loans
Payable and Credit Facilities
  Related Party Convertible Notes   Related Party Loans Payable and Credit Facilities   Total
2019   $ 134,368     $ 10,219     $ 25,508     $ 2,500     $ 172,595  
2020           9,981             2,500       12,481  
2021           34,740             27,521       62,261  
2022           13,417                   13,417  
2023           367                   367  
Thereafter           2,200                   2,200  
Total future minimum payments     134,368       70,924       25,508       32,521       263,321  
Less: amount representing interest(1)     (7,368 )     (18,014 )     (803 )     (7,521 )     (33,706 )
Less: future conversion of accrued interest to principal     (694 )                       (694 )
Present value of minimum debt payments     126,306       52,910       24,705       25,000       228,921  
Less: current portion of debt principal     (126,306 )     (3,829 )     (24,705 )           (154,840 )
Noncurrent portion of debt principal   $     $ 49,081     $     $ 25,000     $ 74,081  

______________

  (1) Excluding net debt discount of $17.1 million that will be amortized to interest expense over the term of the debt.

 

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Convertible Notes Payable

 

6% Convertible Notes Due 2021

 

On December 6, 2018, the Company entered into a securities purchase agreement to issue and sell $60.0 million in aggregate principal amount of senior convertible notes (the 6% Convertible Notes Due 2021) that are convertible into shares of the Company’s common stock. The securities purchase agreement prohibits the Company, subject to certain exceptions, from (i) disposing of any common stock or securities convertible into or exchangeable for shares of common stock during the period commencing on December 6, 2018 and continuing through the later of (A) the date 90 days after December 10, 2018 and (B) the date 30 days after the Registration Statement (as defined below) is declared effective and (ii) effecting or entering into an agreement to effect any issuance involving a variable rate transaction for so long as the 6% Convertible Notes Due 2021 remain outstanding.

 

The closing of the issuance and sale of the 6% Convertible Notes Due 2021 occurred on December 10, 2018, for net proceeds, after deducting offering expenses payable by the Company and placement agent and advisory fees, of $56.2 million.

 

The 6% Convertible Notes Due 2021 are general unsecured obligations of the Company. Unless earlier converted or redeemed, the 6% Convertible Notes Due 2021 will mature on the third anniversary of issuance, subject to the rights of the holders to extend the maturity date in certain circumstances. The 6% Convertible Notes Due 2021 are convertible from time to time, at the election of the holders, into shares of common stock at an initial conversion price of $6.32 per share. The conversion price is subject to adjustment in the event of any stock split, reverse stock split, recapitalization, reorganization or similar transaction. The Company has the option, upon prior notice to the holders, to settle any conversion of the 6% Convertible Notes Due 2021 in cash.

 

The 6% Convertible Notes Due 2021 are payable in equal monthly installments beginning April 1, 2019 (each, an Installment Date), in either cash at 108% of such installment amount or, at the Company’s option, subject to the satisfaction of certain equity conditions (the Equity Conditions), in shares of common stock at a discount to the then-current market price, subject to a price floor (the Installment Conversion Price). The holders have the right, upon notice to the Company, to defer all or any portion of any installment amount to a future Installment Date. In addition, if the Company elects to pay any installments in shares of common stock, the holders of the 6% Convertible Notes Due 2021 have the right to accelerate amounts outstanding under their 6% Convertible Notes Due 2021 during such month up to an aggregate of three times the relevant installment amount.

 

The 6% Convertible Notes Due 2021 bear interest at a rate of 6% per annum, payable quarterly until the first Installment Date, and then at each Installment Date thereafter. Interest on the 6% Convertible Notes Due 2021 may be paid in either cash or, at the Company’s option, subject to the satisfaction of the Equity Conditions, shares of common stock at the Installment Conversion Price. The Company elected to make the interest payment due January 1, 2019 in cash.

 

The 6% Convertible Notes Due 2021 contain customary terms and covenants, including (i) a restriction on the Company’s ability to incur additional indebtedness, (ii) certain events of default, after which the holders may require the Company to redeem all or any portion of their 6% Convertible Notes Due 2021 in cash at a price equal to the greater of (A) 125% of the amount being redeemed and (B) the intrinsic value of the shares of common stock underlying the amount being redeemed, and (iii) certain other events, after which the holders may convert all or any portion of the 6% Convertible Notes Due 2021 at a discount to the Installment Conversion Price.

 

In the event of a Fundamental Transaction (as defined in the 6% Convertible Notes Due 2021), holders of the 6% Convertible Notes Due 2021 may require the Company to redeem all or any portion of their 6% Convertible Notes Due 2021 at a price equal to the greater of (i) 125% of the amount being redeemed and (ii) a premium to the intrinsic value of the shares of Common Stock underlying the amount being redeemed.

 

Notwithstanding the foregoing, the holders will not have the right to convert any portion of a 6% Convertible Note Due 2021, and the Company will not have the option to pay any amount in shares of common stock, if (a) the holder, together with its affiliates, would beneficially own in excess of 4.99% (or such other percentage as determined by the holder and notified to the Company in writing, not to exceed 9.99%, provided that any increase of such percentage will not be effective until 61 days after notice thereof) of the number of shares of common stock outstanding immediately after giving effect to such conversion or payment, as applicable (the Ownership Limitation), or (b) the aggregate number of shares issued with respect to the 6% Convertible Notes Due 2021 (and any other transaction aggregated for such purpose) after giving effect to such conversion or payment, as applicable, would exceed 15,271,047 shares of common stock (the Exchange Cap), unless the Company has obtained prior stockholder approval to issue shares in excess of the Exchange Cap. In the event that (i) the Company is prohibited from issuing any shares of common stock under the 6% Convertible Notes Due 2021 as a result of the Ownership Limitation (other than in connection with a conversion of 6% Convertible Notes Due 2021), such shares shall be held in abeyance (and the related principal amount of the 6% Convertible Notes Due 2021 reinstated) until the holder shall notify the Company and elect to receive such shares without exceeding the Ownership Limitation, and (ii) the Company is prohibited from issuing any shares of common stock under the 6% Convertible Notes Due 2021 as a result of the Exchange Cap, the Company will pay cash in lieu of any shares that would otherwise be deliverable in excess of the Exchange Cap.

 

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In connection with the offering of the 6% Convertible Notes Due 2021, the Company entered into a registration rights agreement, dated December 10, 2018, with the purchasers of the 6% Convertible Notes Due 2021, pursuant to which the Company agreed to file a registration statement (the Registration Statement) with the Securities and Exchange Commission (the SEC) registering the resale of all of the shares of common stock issuable pursuant to the terms of the 6% Convertible Notes Due 2021 (the Registrable Securities) under the Securities Act of 1933, as amended (the Securities Act), within 30 days following December 10, 2018, and to have the Registration Statement declared effective by the SEC by the date that is 60 days after December 10, 2018. In the event that the Registration Statement is not filed or declared effective within the foregoing time frames, or if thereafter, subject to certain exceptions, the Registration Statement is not effective for any reason or the prospectus contained therein is not available for use by the holders, Company shall pay to each holder an amount in cash equal to 2% of such holder’s original principal amount of Notes on the date of such failure and thereafter on every 30 day anniversary thereof until such failure is cured or no longer prevents the holders from freely disposing of their Registrable Securities. The Company filed the Registration Statement on January 8, 2019, and it went effective on February 7, 2019.

 

The Company has elected to account for the 6% Convertible Notes Due 2021 at fair value pursuant to U.S. GAAP, as of the issuance date. Management believes that the fair value option better reflects the underlying economics of the 6% Convertible Notes Due 2021, which contain multiple embedded derivatives. Under the fair value election, changes in fair value will be reported in the consolidated statements of operations as "Gain (loss) from change in fair value of debt" in each reporting period subsequent to the issuance of the 6% Convertible Notes Due 2021. For the year ended December 31, 2018, the Company recorded a gain of $2.1 million, which is shown as Change in Fair Value in the table at the beginning of this Note 4. See Note 4, "Fair Value Measurement" for information about the assumptions that the Company used to measure the fair value of the 6% Convertible Notes Due 2021.

 

In May, June and July 2019, the Company exchanged the 6% Convertible Notes Due 2021 for new senior convertible notes and warrants to purchase common stock. See Note 16, “Subsequent Events” for additional information.

 

2015 Rule 144A Convertible Notes

 

In October 2015, the Company sold $57.6 million aggregate principal amount of 9.50% convertible senior notes due 2019 (the 2015 Rule 144A Convertible Notes) to certain qualified institutional buyers in a private placement. Net proceeds from the offering were $54.4 million after payment of offering expenses and placement agent fees, which together are treated as a debt discount and are being amortized over the remaining loan term using the effective interest method. The Company used $18.3 million of the net proceeds to repurchase $22.9 million aggregate principal amount of outstanding 2014 Rule 144A Convertible Notes as discussed below. The 2015 Rule 144A Convertible Notes bear interest at a rate of 9.50% per year, payable semiannually in arrears on April 15 and October 15 of each year. Interest on the 2015 Rule 144A Convertible Notes is payable, at the Company's option, entirely in cash or entirely in common stock valued at 92.5% of a market-based price. The Company elected to make the April 15, 2016 and 2017 and October 15, 2018 interest payments in shares of common stock and the October 15, 2016 and 2017 and April 15, 2018 interest payments in cash. The 2015 Rule 144A Convertible Notes matured on April 15, 2019. See Note 16, "Subsequent Events".

 

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The 2015 Rule 144A Convertible Notes are convertible into shares of the Company's common stock at a conversion rate of 61.7246 shares per $1,000 principal amount of 2015 Rule 144A Convertible Notes (which conversion rate is subject to adjustment in certain circumstances), representing an effective conversion price of approximately $16.20 per share as of December 31, 2018. If converted prior to maturity, noteholders are entitled to receive a payment (the Early Conversion Payment) equal to the present value of the remaining scheduled payments of interest on the 2015 Rule 144A Convertible Notes being converted through April 15, 2019, computed using a discount rate of 0.75%. The Company may make the Early Conversion Payment, at its election, either in cash or, subject to certain conditions, in common stock valued at 92.5% of a market-based price. Through December 31, 2018, the Company has elected to make each Early Conversion Payment in shares of common stock.

 

In January 2017, the Company issued an additional $19.1 million in aggregate principal amount of 2015 Rule 144A Convertible Notes (the Additional 2015 Rule 144A Convertible Notes) in exchange for the cancellation of $15.3 million in aggregate principal amount of other outstanding convertible promissory notes of the Company, with the same terms as the 2015 Rule 144A Convertible Notes; provided, that the aggregate number of shares issued with respect to the Additional 2015 Rule 144A Convertible Notes (and any other transaction aggregated for such purpose) cannot exceed 3,652,935 shares of common stock without prior stockholder approval. The exchange was accounted for as an extinguishment of debt, resulting in a $0.1 million gain in the year ended December 31, 2017.

 

In May 2017, the Company exchanged $3.7 million in aggregate principal amount of 2015 Rule 144A Convertible Notes for shares of its Series B 17.38% Convertible Preferred Stock and warrants to purchase common stock, as described in more detail in Note 7, “Stockholders’ Deficit”. The exchange was accounted for as an extinguishment of debt, resulting in a $2.0 million loss in the year ended December 31, 2017.

 

On April 16, 2019, the Company repaid the 2015 Rule 144A Convertible Notes in full in cash. See Note 16, “Subsequent Events”. 

 

2014 Rule 144A Convertible Notes

 

In May 2014, the Company sold $75.0 million in aggregate principal amount of 6.50% Convertible Senior Notes due 2019 (the 2014 Rule 144A Convertible Notes) to qualified institutional buyers in a private placement. The net proceeds from the offering were $72.0 million after payment of initial purchaser discounts and offering expenses, which together are treated as a debt discount and are being amortized over the remaining loan term. The Company used $9.7 million of the net proceeds to repay convertible notes previously issued to an affiliate of Total S.A. (together with its affiliates, Total), representing the amount of 2014 Rule 144A Convertible Notes purchased by Total. Certain of the Company's affiliated entities (including Total) purchased $24.7 million in aggregate principal amount of 2014 Rule 144A Convertible Notes. The 2014 Rule 144A Convertible Notes bear interest at an annual rate of 6.5%, payable semiannually in arrears on May 15 and November 15 of each year in cash. The 2014 Rule 144A Convertible Notes mature on May 15, 2019, unless earlier converted or repurchased. 

 

The 2014 Rule 144A Convertible Notes are convertible into shares of the Company's common stock at a conversion rate of 17.8073 shares per $1,000 principal amount of 2014 Rule 144A Convertible Notes (which conversion rate is subject to adjustment in certain circumstances), representing an effective conversion price of approximately $56.16 per share as of December 31, 2018.

 

In May 2017, the Company exchanged $3.4 million in aggregate principal amount of 2014 Rule 144A Convertible Notes for shares of its Series B 17.38% Convertible Preferred Stock and warrants to purchase common stock, as described in more detail in Note 7, “Stockholders’ Deficit". The exchange was accounted for as an extinguishment, resulting in a $1.8 million loss for the year ended December 31, 2017.

 

In May 2019, the Company exchanged a portion of the 2014 Rule 144A Convertible Notes, representing $38.2 million aggregate principal amount of 2014 Rule 144A Convertible Notes, for shares of common stock, warrants to purchase common stock and a new senior convertible note (see Note 16, “Subsequent Events” for additional information) and repaid the remaining portion of the 2014 Rule 144A Convertible Notes in cash at maturity.

 

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August 2013 Financing Convertible Notes

 

In August 2013, the Company entered into a Securities Purchase Agreement (the August 2013 SPA) with Total and Temasek to sell up to $73.0 million in convertible notes in private placements (the August 2013 Financing or the Tranche Notes). The August 2013 SPA provided for the August 2013 Financing to be divided into two tranches, each with differing closing conditions. The Tranche I Notes were due sixty months from the date of issuance (October 16, 2018). Interest accrued on the Tranche I Notes at 5% per six months, compounded semiannually, and was payable in kind by adding to the principal or in cash. Through maturity, the Company elected to pay interest on the Tranche I Notes in kind. The Tranche I Notes totaling $15.2 million of principal and accrued interest matured and were repaid in full by conversion into shares of common stock on October 16, 2018 pursuant to the Maturity Treatment Agreement terms (see “Related Party Convertible Notes Payable - August 2013 Financing Convertible Notes” below). Upon conversion of the Tranche I Notes, the Company recognized a $10.9 million loss upon extinguishment of debt in 2018. See the "Maturity Treatment Agreement" section below for details of the impact of that agreement on the Tranche Notes.

 

The Tranche II Notes are due sixty months from the date of issuance (January 15, 2019). Interest accrues on the Tranche II Notes at 10% per annum, compounded annually, and is payable in kind by adding to the principal or in cash. Through December 31, 2018, the Company has elected to repay interest on the Tranche II Notes in kind. On November 8, 2018, the Company repaid in full the Tranche II Notes held by Total totaling $9.8 million of principal and accrued interest by conversion into shares of common stock pursuant to the Maturity Treatment Agreement terms (see “Related Party Convertible Notes Payable - August 2013 Financing Convertible Notes” below). Upon conversion of the Tranche II Notes held by Total, the Company recognized a $6.5 million loss upon extinguishment of debt.

 

In August 2018, in connection with certain amendments to the August 2017 Vivo Cash Warrants (see Note 7, “Stockholders' Deficit”), the conversion price of the Tranche Notes I and II was reduced from $5.2977 per share to $4.40 per share. As of December 31, 2018, the conversion price of the remaining Tranche II Notes held by Wolverine Flagship Fund Trading Limited (Wolverine) is $4.40 per share (which conversion price is subject to adjustment in certain circumstances, including certain price-based anti-dilution adjustments). The August 2013 SPA and the Tranche Notes contain customary terms, covenants and restrictions, including a limit on the Company’s debt, subject to certain exceptions and waivers, of the greater of $200 million or 50% of its consolidated total assets and the Company’s secured debt of the greater of $125 million or 30% of its consolidated total assets. The August 2013 SPA also requires the Company to obtain the consent of the holders of a majority of these notes before completing any change of control transaction or purchasing assets in one transaction or in a series of related transactions in an amount greater than $20.0 million, in each case while any Tranche Notes are outstanding. In addition, the Tranche Notes contain certain events of default after which the Tranche Notes may become due and payable immediately.

 

On January 14, 2019, Wolverine agreed to waive payment of the Tranche II Note held by Wolverine at maturity until July 15, 2019 in exchange for a cash waiver fee, payable on or prior to July 15, 2019, of $0.6 million. On July 2, 2019, the Company and Wolverine entered into an exchange agreement whereby the parties agreed to extinguish the Tranche II Note held by Wolverine in exchange for 1,767,632 shares of common stock and a warrant to purchase 1,080,000 shares of common stock. See Note 16, “Subsequent Events” for additional information.

 

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Maturity Treatment Agreement

 

In July 2015, the Company entered into an Exchange Agreement (the 2015 Exchange Agreement) with Total and Temasek pursuant to which Temasek exchanged $71.0 million in principal amount of outstanding Tranche Notes and Total exchanged $70.0 million in principal amount of outstanding convertible notes for shares of the Company's common stock at a price of $34.50 per share (2015 Exchange). At the closing of the 2015 Exchange, the Company, Total and Temasek also entered into a Maturity Treatment Agreement dated July 29, 2015, pursuant to which Total and Temasek agreed to convert any Tranche Notes or 2014 144A Notes held by them that were not canceled in the 2015 Exchange (Remaining Notes) into shares of the Company's common stock in accordance with the terms of such Remaining Notes at or prior to maturity, provided that certain events of default had not occurred with respect to the applicable Remaining Notes. In May 2017, the Company entered into separate letter agreements with each of Total and Temasek, pursuant to which the Company agreed that the Remaining Notes consisting of 2014 144A Notes held by Total ($9.7 million in principal amount as of December 31, 2017) and Temasek ($10.0 million in principal amount as of December 31, 2017) would no longer be subject to mandatory conversion at or prior to the maturity of such Remaining Notes. Accordingly, the Company will be required to pay any portion of such Remaining Notes that remain outstanding at maturity in cash in accordance with the terms of such Remaining Notes. As of December 31, 2017, after giving effect to such letter agreements, Temasek did not hold any Remaining Notes and Total held $21.8 million in principal amount of Remaining Notes (consisting of Tranche Notes), which Remaining Notes were converted to common stock in October and November 2018 pursuant to the terms of the Maturity Treatment Agreement (see below under "Related Party Convertible Notes Payable - August 2013 Financing Convertible Notes" for more information). The 2015 Exchange Agreement contains customary terms, covenants and restrictions, including a limit on the Company’s debt of the greater of $200 million or 50% of its consolidated total assets and the Company’s secured debt of the greater of $125 million or 30% of its consolidated total assets, subject to certain exceptions.

 

December 2017 Convertible Note

 

In December 2017, the Company issued and sold a convertible note under an April 2017 securities purchase agreement in the principal amount of $5.0 million with a maturity date of June 1, 2018, for proceeds to the Company of $5.0 million. The Company identified certain embedded feature that required bifurcation, but the fair value of these derivative features was $0, due primarily to the short-term maturity of the note and a significant out of the money conversion price at issuance and through the maturity date. The Company elected to pay each installment in cash, and the note was repaid in full in May 2018.

 

Related Party Convertible Notes Payable

 

August 2013 Financing Convertible Notes

 

Certain of the August 2013 Financing Convertible Notes were held by related parties; see Note 11, "Related Party Transactions" for details.

 

On October 16, 2018, the Tranche I Notes held by Total totaling $15.2 million of principal and accrued interest reached maturity and were converted into 3,448,821 shares of common stock. Upon conversion of the Tranche I Notes, the Company recognized a $10.9 million loss upon extinguishment of debt.

 

On November 8, 2018, Total converted its Tranche II Notes totaling $9.8 million of principal and accrued interest, which were scheduled to mature on January 15, 2019, into shares of common stock. In connection with such conversion, the Company agreed to pay Total future interest on the Tranche II Notes being converted up to, but excluding, the maturity date for such notes, which interest was converted by Total into common stock at the conversion price for the Tranche II Notes. As a result of such conversion, the Tranche II Notes held by Total converted into 2,226,105 shares of common stock. Upon conversion of the Tranche II Notes held by Total, the Company recognized a $6.5 million loss upon extinguishment of debt.

 

2014 Rule 144A Convertible Notes

 

Certain of the 2014 Rule 144A Convertible Notes are held by related parties. See Note 11, "Related Party Transactions" for details.

 

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R&D Note

 

In March 2016, as a result of the restructuring of the Company’s fuels joint venture with Total, Total Amyris BioSolutions B.V., the Company issued to Total an unsecured convertible note (the R&D Note) in the principal amount of $3.7 million, representing the remaining portion of the $105.0 million convertible note facility between the Company and Total initially established in 2012. In March and May 2018, the Company and Total amended the R&D Note to extend the maturity to May 31, 2018 and July 2, 2018, respectively, with accrued and unpaid interest payable on March 31, 2018, May 31, 2018 and July 2, 2018. On July 2, 2018, the Company repaid the R&D Note in full.

 

Loans Payable and Credit Facilities

 

GACP Term Loan Facility

 

On June 29, 2018, the Company, certain of the Company’s subsidiaries and GACP Finance Co., LLC (GACP) entered into a Loan and Security Agreement (the LSA) to borrow a $36.0 million secured term loan (the GACP Term Loan Facility). The LSA also provides for an incremental secured term loan facility in an aggregate principal amount of up to $35.0 million (the Incremental GACP Term Loan Facility and, together with the GACP Term Loan Facility, the GACP Term Loan Facilities), subject to certain conditions and approvals, to fund the construction of a custom-built manufacturing facility in Brazil. The majority of the net proceeds from the GACP Term Loan Facility were used to repay all amounts outstanding under the Senior Secured Loan Facility between the Company and Stegodon described below. The remaining net proceeds were used on July 2, 2018 to repay amounts outstanding under the R&D Note at maturity, as described above.

 

Loans under the GACP Term Loan Facilities have a maturity date of July 1, 2021; provided, that if the Company has not (i) met certain financial conditions on or prior to January 7, 2019 or (ii) refinanced the 2015 Rule 144A Convertible Notes and 2014 Rule 144A Convertible Notes with indebtedness that has a maturity date which is later than July 1, 2021 or converted such notes into equity prior to January 12, 2019, then the maturity date will be January 12, 2019. See Note 16, “Subsequent Events” for additional information about the waiver of this provision. The GACP Term Loan Facilities will amortize beginning on July 1, 2019 in quarterly installments equal to 2.5% of the original loan amounts, with the remaining principal balance payable on the maturity date. Loans under the GACP Term Loan Facilities initially accrued interest at a rate per annum equal to the sum of (i) the greater of (A) the U.S. prime rate as reported in the Wall Street Journal and (B) 4.0%, plus (ii) 6.25%, payable monthly. The GACP Term Loan Facilities are guaranteed by the subsidiaries of the Company party to the LSA and collateralized by first-priority liens on substantially all the Company’s and such subsidiaries’ assets, including intellectual property, subject to certain exceptions. The LSA includes customary terms, covenants and restrictions, including mandatory prepayments upon the occurrence of certain events, including asset sales, casualty events, incurrence of additional indebtedness and borrowing base deficiencies, subject to certain exceptions and reinvestment rights. The LSA contains certain financial covenants that include quarterly minimum revenues, minimum liquidity amounts and a minimum asset coverage ratio.

 

The Company paid origination fees at closing equal to 4%, or $1.4 million, of the funded amount of the GACP Term Loan Facility and other closing costs totaling $0.2 million, plus an agency fee of $25,000 per quarter during the term of the GACP Term Loan Facilities. The $1.6 million of issuance costs will be amortized using the effective interest method over the expected 3-year loan term.

 

In November 2018, the Company and GACP amended the LSA to reduce the minimum revenue requirement for the two fiscal quarters ending December 31, 2018 in exchange for an increase in optional prepayment fees, an increase in the minimum liquidity amount and an increase in the base interest rate per annum, from the sum of (i) the greater of (A) the prime rate as reported in the Wall Street Journal or (B) 4.0% plus (ii) 6.25% to the sum of (i) the greater of (A) the prime rate as reported in the Wall Street Journal or (B) 4.0% plus (ii) 8.25%. In December 2018, the Company and GACP further amended the LSA to exclude certain intellectual property licensed to DSM from the loan collateral (see Note 10, “Revenue Recognition” for more information) in exchange for a further increase in the base interest rate per annum, from the sum of (i) the greater of (A) the prime rate as reported in the Wall Street Journal or (B) 4.0% plus (ii) 8.25% to the sum of (i) the greater of (A) the prime rate as reported in the Wall Street Journal or (B) 4.75% plus (ii) 9.00%.

 

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In April 2019, (i) GACP provided a waiver to the Company for breaches of all covenant violations under the GACP loan and security agreement (LSA) occurring prior to, as of and after December 31, 2018 through April 8, 2019, and (ii) GACP sold and assigned the loans under the LSA and all documents and assets related thereto to Foris Ventures, LLC (Foris). Subsequently, Foris provided a waiver to the Company for breaches of certain covenants under the LSA through June 30, 2020 and amended the financial covenants under the LSA to provide more favorable compliance terms and conditions. See Note 16, "Subsequent Events" for additional information.

 

Senior Secured Loan Facility

 

In March 2014, the Company entered into a Loan and Security Agreement (the LSA) with Hercules Technology Growth Capital, Inc. to make available to the Company a secured loan facility (the Senior Secured Loan Facility) in an initial aggregate principal amount of up to $25.0 million. The LSA was subsequently amended in June 2014, March 2015 and November 2015 to (i) extend additional credit facilities to the Company in an aggregate amount of up to $31.0 million, of which $16.0 million was drawn by the Company, (ii) extend the maturity date of the loans, and (iii) remove, add and/or modify certain covenants and agreements under the LSA.

 

In June 2016, Hercules transferred and assigned its rights and obligations under the Senior Secured Loan Facility to Stegodon Corporation (Stegodon), an affiliate of Ginkgo Bioworks, Inc. (Ginkgo).

 

In March and May 2018, the Company and Stegodon amended the LSA to extend the date for a $5.5 million principal payment to May 31, 2018 and July 2, 2018, respectively. Under the amendments, the interest rate from April 1, 2018 through the date of such $5.5 million principal payment would be the previously agreed interest rate plus 5.0%.

 

On June 29, 2018, the Company repaid the Senior Secured Loan Facility in full.

 

Ginkgo Note

 

In November 2017, the Company issued an unsecured promissory note in the principal amount of $12.0 million to Ginkgo (the November 2017 Ginkgo Note) in connection with the termination of the Ginkgo Collaboration Agreement and the execution of a new partnership agreement (the Ginkgo Partnership Agreement), which is described in Note 10, "Revenue Recognition". The November 2017 Ginkgo Note bears interest at 10.5% per annum, payable monthly, and has a maturity date of October 19, 2022. The November 2017 Ginkgo Note may be prepaid in full without penalty or premium at any time, provided that certain payments have been made under the Company’s partnership agreement with Ginkgo. The November 2017 Ginkgo Note also contains customary terms, covenants and restrictions, including certain events of default after which the note may become due and payable immediately. The Company recorded the $7.0 million present value of the November 2017 Ginkgo Note as a note payable liability, and the remaining $5.0 million was recorded as a debt discount which is being accreted to interest expense over the loan term using the effective interest method. Also, the Company concluded that while no cash was received from Ginkgo under the November 2017 Ginkgo Note, the transaction represents consideration payable to a former customer and the present value of the note payable obligation should be recorded as a reduction of cumulative revenue recognized to date from Ginkgo in the period the November 2017 Ginkgo Note was executed. As a result, the Company recorded a $7.0 million reduction of license revenues as of December 31, 2017. See Note 10, "Revenue Recognition" for additional information.

 

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Other Loans Payable

 

Nikko Note: In December 2016, in connection with the Company's formation of its cosmetics joint venture (the Aprinnova JV) with Nikko Chemicals Co., Ltd. (Nikko) made a loan to the Company in the principal amount of $3.9 million and the Company issued a promissory note (the Nikko Note) to Nikko in an equal principal amount. The proceeds of the Nikko Note were used to satisfy the Company's remaining liabilities related to the Company's purchase of a manufacturing facility in Leland, North Carolina and related assets in December 2016, including liabilities under a promissory note in the principal amount of $3.5 million issued in connection therewith. The Nikko Note (i) bears interest at 5% per year, (ii) has a term of 13 years, (iii) is payable in equal monthly installments of principal and interest beginning on January 1, 2017 and (iv) is secured by a first-priority lien on 10% of the Aprinnova JV interests owned by the Company. In addition, (i) the Company repaid $400,000 of the Nikko Note in equal monthly installments of $100,000 as required on January 1, 2017, February 1, 2017, March 1, 2017 and April 1, 2017 and (ii) the Company is required to repay the Nikko Note with any profits distributed to the Company by the Aprinnova JV, beginning with the distributions for the fourth fiscal year of the Aprinnova JV, until the Nikko Note is fully repaid. The Nikko Note may be prepaid in full or in part at any time without penalty or premium. The Nikko Note contains customary terms and provisions, including certain events of default after which the Nikko Note may become due and payable immediately.

 

Aprinnova Working Capital Loans: In February 2017, in connection with the formation of the Aprinnova JV in December 2016, Nikko made a working capital loan to the Aprinnova JV in the principal amount of $1.5 million and received a promissory note from the Aprinnova JV in an equal amount (the First Aprinnova Note). The First Aprinnova Note was repayable in $375,000 installments plus accrued interest on May 1, 2017, August 1, 2017, November 1, 2017 and February 1, 2018. The First Aprinnova Note was fully repaid in January 2018. In August 2017, Nikko made a second working capital loan to the Aprinnova JV in the principal amount of $1.5 million and received a promissory note from the Aprinnova JV in an equal amount (the Second Aprinnova Note). The Second Aprinnova Note is payable in full on August 1, 2019, with interest payable quarterly. Both notes bear interest at 2.75% per annum. Effective July 31, 2019, the Company and Nikko agreed to extend the term of the Second Aprinnova Note to August 1, 2020. See Note 16, "Subsequent Events".

 

Related Party Loans Payable

 

DSM Note

 

In December 2017, the Company and DSM entered into a credit agreement (the DSM Credit Agreement) to make available to the Company an unsecured credit facility of $25.0 million. On December 28, 2017, the Company borrowed $25.0 million under the DSM Credit Agreement, representing the entire amount available thereunder, and issued a promissory note to DSM in an equal principal amount (the DSM Note). The Company used the proceeds of the amounts borrowed under the DSM Credit Agreement to repay all outstanding principal under a promissory note in the principal amount of $25 million issued to Guanfu Holding Co., Ltd. in December 2016 (the Guanfu Note). Given multiple elements in the arrangements with DSM, the Company fair valued the DSM Note to determine the arrangement consideration that should be allocated to the DSM Note. The fair value of the DSM Note was discounted using a Company specific weighted average cost of capital rate that resulted in a debt discount of $8.0 million. The debt discount is being amortized over the loan term using the effective interest method.

 

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The DSM Note (i) is an unsecured obligation of the Company, (ii) matures on December 31, 2021 and (iii) accrues interest from and including December 28, 2017 at 10% per annum, payable quarterly. The DSM Note may be prepaid in full or in part at any time without penalty or premium. In addition, the Company is required to use certain payments received by the Company from DSM under the Value Sharing Agreement (see Note 10, “Revenue Recognition”) to repay amounts outstanding under the DSM Credit Agreement. The DSM Credit Agreement and the DSM Note contain customary terms, covenants and restrictions, including certain events of default after which the DSM Note may become due and payable immediately.

 

February 2016 Private Placement

 

In February 2016, the Company issued and sold $20.0 million in aggregate principal amount of promissory notes (the February 2016 Notes), as well as warrants to purchase an aggregate of 190,477 shares of the Company's common stock, exercisable at a price of $0.15 per share as of December 31, 2018 (the February 2016 Warrants), resulting in aggregate proceeds to the Company of $20.0 million, in a private placement to certain existing stockholders of the Company that are affiliated with members of the Company's Board of Directors (the Board): Foris Ventures, LLC (Foris, an entity affiliated with director John Doerr of Kleiner Perkins Caufield & Byers, a current stockholder, and an owner of greater than five percent of the Company’s outstanding common stock), which purchased $16.0 million aggregate principal amount of the February 2016 Notes and warrants to purchase 152,381 shares of the Company's common stock; Naxyris S.A. (Naxyris, an investment vehicle owned by Naxos Capital Partners SCA Sicar; director Carole Piwnica is Director of NAXOS UK, which is affiliated with Naxos Capital Partners SCA Sicar, and was designated as a director of the Company by Naxyris), which purchased $2.0 million aggregate principal amount of the February 2016 Notes and warrants to purchase 19,048 shares of the Company's common stock; and Biolding Investment SA (Biolding, a fund affiliated with director HH Sheikh Abdullah bin Khalifa Al Thani, who was designated as a director of the Company by Biolding), which purchased $2.0 million aggregate principal amount of the February 2016 Notes and warrants to purchase 19,048 shares of the Company's common stock.

 

The February 2016 Notes bore interest at 13.50% per annum and had an initial maturity date of May 15, 2017. In May 2017, the February 2016 Notes purchased by Foris and Naxyris were exchanged for shares of the Company’s Series B 17.38% Convertible Preferred Stock and warrants to purchase common stock; see Note 7, “Stockholders’ Deficit”.

 

In May 2017, the Company and Biolding amended the February 2016 Note issued to Biolding (the Biolding Note) to extend the maturity of the Biolding Note to November 15, 2017, and on November 13, 2017, the Company and Biolding further amended the Biolding Note to extend the maturity to December 31, 2017. The Company paid the Biolding Note in full on January 2, 2018.

 

The February 2016 Warrants each have five-year terms. The February 2016 Warrants purchased by Naxyris were fully exercised in the year ended December 31, 2017, and a gain of $0.1 million was recorded in earnings. As of December 31, 2018, none of the 171,429 February 2016 Warrants purchased by Foris or Biolding have been exercised.

 

For information regarding related party loans payable subsequent to December 31, 2018, see Note 16, “Subsequent Events”.

 

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Letters of Credit

 

In June 2012, the Company entered into a letter of credit agreement for $1.0 million under which it provided a letter of credit to the landlord for its headquarters in Emeryville, California in order to cover the security deposit on the lease. This letter of credit is secured by a certificate of deposit. Accordingly, the Company has $1.0 million of restricted cash, noncurrent in connection with this arrangement as of December 31, 2018 and 2017.

 

6. Mezzanine Equity

 

Mezzanine equity at December 31, 2018 and 2017 is comprised of proceeds from common shares sold on May 10, 2016 to the Bill & Melinda Gates Foundation (the Gates Foundation). On April 8, 2016, the Company entered into a Securities Purchase Agreement with the Gates Foundation, pursuant to which the Company agreed to sell and issue 292,398 shares of its common stock to the Gates Foundation in a private placement at a purchase price per share of $17.10, the average of the daily closing price per share of the Company’s common stock on the Nasdaq Stock Market for the twenty consecutive trading days ending on April 7, 2016, for aggregate proceeds to the Company of approximately $5.0 million (the Gates Foundation Investment). The Securities Purchase Agreement includes customary representations, warranties and covenants of the parties.

 

In connection with the entry into the Securities Purchase Agreement, on April 8, 2016, the Company and the Gates Foundation entered into a Charitable Purposes Letter Agreement, pursuant to which the Company agreed to expend an aggregate amount not less than the amount of the Gates Foundation Investment to develop a yeast strain that produces artemisinic acid and/or amorphadiene at a low cost and to supply such artemisinic acid and amorphadiene to companies qualified to convert artemisinic acid and amorphadiene to artemisinin for inclusion in artemisinin combination therapies used to treat malaria commencing in 2017. The Company is currently conducting the project. If the Company defaults in its obligation to use the proceeds from the Gates Foundation Investment as set forth above or defaults under certain other commitments in the Charitable Purposes Letter Agreement, the Gates Foundation will have the right to request that the Company redeem, or facilitate the purchase by a third party of, the Gates Foundation Investment shares then held by the Gates Foundation at a price per share equal to the greater of (i) the closing price of the Company’s common stock on the trading day prior to the redemption or purchase, as applicable, or (ii) an amount equal to $17.10 plus a compounded annual return of 10%. As of December 31, 2018, the Company's remaining research and development obligation under this arrangement was $0.7 million.

 

7. Stockholders’ Deficit

 

Warrants

 

The Company issues warrants in certain debt and equity transactions in order to facilitate raising equity capital or reduce borrowing costs. In connection with various debt and equity transactions (see Note 5, "Debt" and below), the Company has issued warrants exercisable for shares of common stock. The May 2017 and August 2017 cash and dilution warrants, and the July 2015 related party debt exchange warrants are accounted for as derivative liabilities. See the Temasek Funding Warrant and Series A and B sections below for more information. The following table summarizes warrant activity for the year ended December 31, 2018:

 

 

Transaction   Number Outstanding as of
December 31, 2017
  Additional
Warrants Issued
  Exercises   Number Outstanding as of
December 31, 2018
August 2018 warrant exercise agreements           12,097,164             12,097,164  
May 2017 cash and dilution warrants     18,042,568             (11,749,770 )     6,292,798  
August 2017 cash and dilution warrants     9,543,234       1,713,565       (7,288,683 )     3,968,116  
April 2018 warrant exercise agreements           3,616,174             3,616,174  
July 2015 related party debt exchange     2,082,010       471,204       (1,889,986 )     663,228  
February 2016 related party private placement     171,429                   171,429  
July 2015 private placement     81,197                   81,197  
Other     1,406                   1,406  
      29,921,844       17,898,107       (20,928,439 )     26,891,512  

 

For information regarding warrants issued subsequent to December 31, 2018, see Note 16, “Subsequent Events”.

 

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Shares Issuable under Convertible Notes

 

In connection with various debt transactions (see Note 5, "Debt"), the Company issued certain convertible notes that are convertible into shares of common stock as follows as of December 31, 2018, at any time at the election of each debtholder:

 

Debt Instrument   Number of Shares into Which
Debt Instrument Is Convertible
as of December 31, 2018
6% convertible notes due 2021     9,493,672  
2015 Rule 144A convertible notes     2,338,560  
August 2013 financing convertible notes     1,003,554  
2014 Rule 144A convertible notes     867,376  
      13,703,162  

 

2018 Warrant Exercises and New Warrant Issuances

 

April 2018 Warrant Transactions

 

On April 12, 2018, in accordance with the terms of the Warrant Exercise Agreement, certain holders of the May 2017 Warrants (see below under “May 2017 Offerings”) exercised their May 2017 Cash Warrants in full to purchase an aggregate of 3,616,174 shares of common stock for net proceeds to the Company of $14.5 million and surrendered their May 2017 Dilution Warrants for cancellation. Upon exercise of the May 2017 Cash Warrants and surrender of such May 2017 Dilution Warrants, certain derivative liabilities representing certain anti-dilution rights contained in the May 2017 Warrants were effectively settled. Under the terms of the Warrant Exercise Agreements, the exercise of such May 2017 Cash Warrants and surrender of such May 2017 Dilution Warrants was required on the date of the Warrant Exercise Agreement in order for the Company to issue new warrants to these same holders to purchase an aggregate of 3,616,174 shares of common stock, exercisable at a price of $7.00 per share. The new warrants were fully exercisable upon issuance, with an expiration date of July 12, 2019. The new warrants do not provide the holders with anti-dilution protection and only permit “cashless” exercise after the six-month anniversary of issuance, and only to the extent that there is not an effective registration statement covering the resale of the shares of common stock underlying the new warrants; on September 26, 2018, the Company filed such a registration statement, which was declared effective on October 11, 2018. The new warrants were evaluated for liability classification, and while meeting the definition of a derivative, the freestanding instruments met the indexation and equity classification criteria to be accounted for as equity.

 

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August 2018 Warrant Transactions

 

In August 2018 in accordance with the terms of the Warrant Exercise Agreements, Foris Ventures, LLC (Foris) and entities affiliated with Vivo Capital LLC (Vivo), related parties and holders of the May 2017 Warrants and August 2017 Warrants (see below under “August 2017 Vivo Offering”), respectively, exercised their Cash Warrants and, in the case of Foris, Dilution Warrants in full and in accordance with the terms of the Warrant Exercise Agreements, to purchase an aggregate of approximately 12.6 million shares of common stock for $43.0 million in proceeds to the Company, and Vivo subsequently surrendered their Dilution Warrants for cancellation. In connection with the entry by the Company and Vivo into Warrant Exercise Agreement, the Company and Vivo amended the August 2017 Vivo Cash Warrants to (i) reduce the exercise price of such warrants from $6.39 per share to $4.40 per share and (ii) remove the August 2017 Vivo Offering Beneficial Ownership Limitation from such warrants. Upon exercise and surrender of such Cash Warrants and Dilution Warrants, certain derivative liabilities representing certain anti-dilution rights contained in the May 2017 Warrants and August 2017 Warrants were effectively settled. Under the terms of the Warrants Exercise Agreement, the exercise of the Cash Warrants and Dilution Warrants and subsequent surrender of the Vivo Dilution Warrants was required on the date of the Warrants Exercise Agreement in order for the Company to issue a series of new warrants to these same holders to purchase an aggregate of 12.1 million shares of common stock, exercisable at $7.52 per share. The new warrants are exercisable any time after the six-month anniversary of issuance and for 15 months thereafter, with an expiration date in May 2020. The new warrants do not provide the holders with anti-dilution protection and only permit “cashless” exercise after the twelve-month anniversary of issuance, and only to the extent that there is not an effective registration statement covering the resale of the shares of common stock underlying the new warrants. The new warrants were evaluated for liability classification, and while meeting the definition of a derivative, the freestanding instruments met the indexation and equity classification criteria to be accounted for as equity.

 

Temasek Funding Warrant – Related Party

 

Following amendments to certain common stock purchase warrants in August 2018 (see below under “May 2017 Offerings” and “August 2017 Vivo Offering”), and a corresponding adjustment to the conversion price of the August 2013 financing convertible notes from $5.2977 per share to $4.40 per share (see Note 5, “Debt”), the Temasek Funding Warrant became exercisable for an additional 471,204 shares of common stock in accordance with its terms. On October 19, 2018, Temasek exercised the Temasek Funding Warrant with respect to 1,889,986 shares of common stock underlying the Temasek Funding Warrant by means of a cashless exercise, resulting in the issuance of 1,852,585 shares of common stock to Temasek. As of December 31, 2018, there were 471,204 shares underlying the Temasek Funding Warrant. As a result of this exercise, the derivative liability related to the Temasek Funding Warrant decreased by $14.0 million.

 

November 2018 DSM Securities Purchase Agreement – Related Party

 

On November 20, 2018, the Company issued 1,643,991 shares of common stock (the DSM Shares) at $3.68 per share to DSM in a private placement pursuant to a securities purchase agreement, dated November 19, 2018, between the Company and DSM (the DSM SPA), in consideration of certain agreements of DSM set forth in the Supply Agreement Amendment described in Note 10, "Revenue Recognition". The Company also agreed to pay DSM the difference between the DSM SPA purchase price of $4.41 and the closing share price of the Company's common stock on March 28, 2019, multiplied by 1,643,991. At inception, the Company recorded a $1.2 million derivative liability for the difference between $4.41 and the Company’s closing stock price on November 20, 2018. At December 31, 2018 fair value based on the Company’s closing stock price was $1.8 million, resulting in a $0.6 million loss on change in fair value for the year ended December 31, 2018. At March 28, 2019, the Company's stock price was $2.10, and the Company owed DSM $3.8 million in connection with this agreement. Pursuant to the DSM SPA, the Company agreed to file a registration statement providing for the resale by DSM of the DSM Shares and to use commercially reasonable efforts to (i) cause such registration statement to become effective within 181 days following the date of the DSM SPA and (ii) keep such registration statement effective until DSM does not own any DSM Shares or the DSM Shares are eligible for resale under Rule 144 without regard to volume limitations. See Note 11, "Related Party Transactions" for additional information about the accounting for this transaction and other November 2018 transactions with DSM. In April 2019, in connection with the assignment by the Company of its rights under the Value Sharing Agreement (see Note 10, "Revenue Recognition"), the Company satisfied its obligation under the Supply Agreement Amendment relating to the difference between $4.41 and the price of the Company’s common stock on March 28, 2019. See Note 16, “Subsequent Events” for additional information.

 

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At Market Issuance Sales Agreement

 

On March 8, 2016, the Company entered into an At Market Issuance Sales Agreement (ATM Sales Agreement) with FBR Capital Markets & Co. and MLV & Co. LLC (Agents) under which the Company would be able to issue and sell shares of its common stock having an aggregate offering price of up to $50.0 million (ATM Shares) from time to time through the Agents, acting as its sales agents, under the Company's Registration Statement on Form S-3 (File No. 333-203216), effective April 15, 2015. Sales of the ATM Shares through the Agents would be made by any method that is deemed an "at the market offering" as defined in Rule 415 under the Securities Act of 1933, as amended, including by means of ordinary brokers' transactions at market prices, in block transactions, or as otherwise agreed by the Company and the Agents. The Company agreed to pay the applicable Agent a commission rate of up to 3.0% of the gross proceeds from the sale of any ATM Shares sold through such Agent under the ATM Sales Agreement. The ATM Sales Agreement included no commitment by other parties to purchase ATM Shares the Company offers for sale.

 

During the year ended December 31, 2018, the Company issued and sold 205,168 shares of common stock under the ATM Sales Agreement, at an average price of $6.90 per share, resulting in total net proceeds to the Company of $1.4 million. During the year ended December 31, 2017, the Company did not sell any shares of common stock under the ATM Sales Agreement. The ATM Sales Agreement expired on April 15, 2018, and as a result, zero remained available for issuance under the ATM Sales Agreement as of December 31, 2018.

 

May 2017 Offerings

 

In May 2017, the Company issued and sold an aggregate of 22,140 shares of Series A 17.38% Convertible Preferred Stock (Series A Preferred Stock), 70,904 shares of Series B 17.38% Convertible Preferred Stock (Series B Preferred Stock), and warrants to purchase an aggregate of 7,384,190 shares of common stock at an initial exercise price of $7.80 per share, warrants to purchase an aggregate of 7,384,190 shares of common stock at an initial exercise price of $9.30 per share, and warrants to purchase a number of shares of common stock sufficient to provide full-ratchet anti-dilution protection with respect to the effective price paid for the common stock underlying the Series A Preferred Stock and Series B Preferred Stock (collectively, the May 2017 Warrants) in separate offerings, certain of which were registered under the Securities Act or others of which were private placements (collectively, the May 2017 Offerings).

 

The net proceeds to the Company from the May 2017 Offerings were $50.7 million after payment of offering expenses and placement agent fees. The Series A Preferred Stock and May 2017 Warrants relating thereto were sold to the purchasers thereof in exchange for aggregate cash consideration of $22.1 million, and the Series B Preferred Stock and May 2017 Warrants relating thereto were sold to the purchasers thereof in exchange for (i) aggregate cash consideration of $30.7 million and (ii) the cancellation of $40.2 million of outstanding indebtedness (including accrued interest thereon) owed by the Company to certain purchasers, of which $33.1 million was from related parties, as further described below.

 

Series A and B Preferred Stock

 

Series A Preferred Stock

 

Each share of Series A Preferred Stock has a stated value of $1,000 and is convertible at any time, at the option of the holder, into common stock at a conversion price of $17.25 per share (Preferred Stock Conversion Rate). The Preferred Stock Conversion Rate is subject to adjustment in the event of any dividends or distributions of common stock, or any stock split, reverse stock split, recapitalization, reorganization or similar transaction. If not previously converted at the option of the holder, each share of Series A Preferred Stock automatically converted on October 9, 2017, the 90th day following the date that the July 2017 Stockholder Approval (as defined below) was obtained and effected, subject to the May 2017 Offerings Beneficial Ownership Limitation (as defined below).

 

Dividends, at a rate per year equal to 17.38% of the stated value of the Series A Preferred Stock, will be payable semiannually from the issuance of the Series A Preferred Stock until the tenth anniversary of the date of issuance, on each October 15 and April 15, beginning October 15, 2017, on a cumulative basis, at the Company's option, in cash, out of any funds legally available for the payment of dividends, or, subject to the satisfaction of certain conditions, in Common Stock at the Preferred Stock Conversion Rate, or a combination thereof. Upon the conversion of the Series A Preferred Stock prior to the tenth anniversary of the date of issuance, the holders of the Series Preferred A Stock shall be entitled to a payment equal to $1,738 per $1,000 of stated value of the Series A Preferred Stock, less the amount of all prior semiannual dividends paid on such converted Series A Preferred Stock prior to the relevant conversion date (Make-Whole Payment), at the Company's option, in cash, out of any funds legally available for the payment of dividends, or, subject to the satisfaction of certain conditions, in common stock at the Preferred Stock Conversion Rate, or a combination thereof. If the Company elects to pay any dividend in the form of cash, it shall provide each holder with notice of such election not later than the first day of the month of prior to the applicable dividend payment date.

 

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Unless and until converted into common stock in accordance with its terms, the Series A Preferred Stock has no voting rights, other than as required by law or with respect to matters specifically affecting the Series A Preferred Stock.

 

Upon any liquidation, dissolution or winding-up of the Company, the holders of the Series A Preferred Stock shall be entitled to receive out of the assets of the Company the same amount that a holder of Common Stock would receive if the Series A Preferred Stock were fully converted to common stock immediately prior to such liquidation, dissolution or winding-up (without regard to whether such Series A Preferred Stock is convertible at such time), which amount shall be paid pari passu with all holders of Common Stock.

 

The conversion of the Series A Preferred Stock is subject to a beneficial ownership limitation of 4.99% (or such other percentage not to exceed 9.99%, provided that any increase will not be effective until 61 days after notice thereof by the holder) of the number of shares of common stock outstanding immediately after giving effect to the issuance of shares of common stock issuable upon conversion of such Series A Preferred Stock (May 2017 Offerings Beneficial Ownership Limitation). In addition, prior to obtaining the July 2017 Stockholder Approval (as defined below), the aggregate number of shares issued with respect to the Series A Preferred Stock (and any other transaction aggregated for such purpose) could not exceed 3,792,778 shares of common stock (May 2017 Exchange Cap).

 

The Series A Preferred Stock is classified as permanent equity, as the Company controls all actions or events required to settle the optional and mandatory conversion feature in shares. The Make-Whole Payment was determined to be an embedded derivative requiring bifurcation and separate recognition as a derivative liability recognized at its fair value as of the issuance date with subsequent changes in fair value recorded in earnings until the earlier of (i) July 7, 2017 when the Make-Whole shares became fixed and certain, (ii) the Series A Preferred Stock is converted into common stock, (iii) the Make-Whole Payment is voluntarily converted, or (iv) the Make-Whole Payment is paid through declared dividends or cash. A derivative liability was recognized at fair value on the date of issuance for the Make-Whole Payment in the amount of $11.0 million. The value of the remaining Make-Whole derivative liability at July 7, 2017 was extinguished to equity. All Make-Whole Payment conversions into common stock before and after July 7, 2017, were accounted for as a deemed dividend in the period converted. A derivative liability was also recognized at fair value on the date of issuance for the May 2017 Warrants issued to the Series A holders (discussed more fully below) in the amount of $10.6 million. The Series A Preferred Stock also contained a beneficial conversion feature which was recognized up to the amount of $0.6 million of proceeds allocated to the preferred stock. Net proceeds allocated to the Series A Preferred Stock were $0.6 million.

 

As of December 31, 2017, all 22,140 shares of Series A Preferred Stock had been converted into common stock (with the Make-Whole Payment in each case being made in the form of common stock) and zero shares of Series A Preferred Stock were outstanding. Upon conversion of the Series A Preferred Shares, the Company recognized a deemed dividend for the unamortized discount related to the allocation of proceeds to the May 2017 Warrants derivatives totaling $21.6 million, and deemed dividends upon settlement of the Series A Make-Whole Payment totaling $10.5 million, all as a reduction to Additional Paid-in Capital and an increase to net loss attributable to Amyris, Inc. common stockholders.

 

Series B Preferred Stock

 

The Series B Preferred Stock has substantially identical terms to the Series A Preferred Stock, except that (i) the conversion of the Series B Preferred Stock was subject to the July 2017 Stockholder Approval and (ii) the May 2017 Offerings Beneficial Ownership Limitation does not apply to DSM. The Series B Preferred Stock was classified as permanent equity at issuance due to the lack of a cash redemption feature and because the holder’s only recourse to affect conversion was to require the Company to continually seek shareholder approval, thus effectively giving the Company control over the actions or events necessary to settle an optional or mandatory conversion feature in shares. As described in more detail below under “July 2017 Stockholder Approval,” in July 2017 the Company’s stockholders approved removing a restriction preventing the Series B Preferred Stock issued in the May 2017 Offerings from being convertible into common stock.

 

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The investors that purchased shares of the Series B Preferred Stock included related parties affiliated with members of the Board: Foris exchanged an aggregate principal amount of $27.0 million of indebtedness, plus accrued interest thereon, for 30,729 shares of Series B Preferred Stock and May 2017 Warrants to purchase 4,877,386 shares of Common Stock and Naxyris exchanged an aggregate principal amount of $2.0 million of indebtedness, plus accrued interest thereon, for 2,333 shares of Series B Preferred Stock and May 2017 Warrants to purchase 370,404 shares of common stock. The fair value of the Series B Preferred Stock, the embedded Make-Whole payment and the related warrants exceeded the carrying value of the related party debt and accrued interest exchanged by $8.6 million which was recorded as a loss upon extinguishment of debt as the Company determined that the related parties were acting in their interests as debt holders.

 

The investors that purchased shares of the Series B Preferred Stock also included non-related party holders of the Company's 2014 Rule 144A Convertible Notes and 2015 Rule 144A Convertible Notes. These investors exchanged all or a portion of their holding of such indebtedness, including accrued interest thereon, representing an aggregate of $3.4 million of 2014 Rule 144A Convertible Notes and $3.7 million of 2015 Rule 144A Convertible Notes, for Series B Preferred Stock and May 2017 Warrants in the May 2017 Offerings. The fair value of the Series B Preferred Stock, the embedded Make-Whole payment and the related warrants exceeded the carrying value of the debt and accrued interest exchanged by $1.9 million, which was recognized as a loss on extinguishment of debt in other income (expense).

 

Issuance costs of $1.2 million were netted against the proceeds. Additional issuance costs of $0.2 million were expensed as debt extinguishment costs for debt that was exchanged in the May 2017 Offerings.

 

Upon the closing of the May 2017 Offerings, all such exchanged indebtedness was canceled and the agreements relating thereto, including any note purchase agreements or unsecured or secured promissory notes (including any security interest relating thereto), were terminated, except to the extent such investors or other investors retain a portion of such indebtedness.

 

A derivative liability was recognized at fair value on the date of issuance for the May 2017 DSM Series B Make-Whole Payment in the amount of $12.4 million. A derivative liability was also recognized at fair value on the date of issuance for the May 2017 Warrants issued to DSM (discussed more fully below) in the amount of $11.9 million. Upon conversion of the DSM Series B Preferred Shares, the Company recognized a deemed dividend for the unamortized discounts related to the allocation of proceeds to the May 2017 DSM Make-Whole Payment and May 2017 Warrants derivatives totaling $24.4 million, and a deemed dividend upon settlement of all May 2017 Series B Make-Whole Payments totaling $22.6 million, all as a reduction to Additional Paid in Capital and an increase to net loss attributable to Amyris, Inc. common stockholders. The Series B Preferred Stock issued to DSM in the May 2017 Offerings also contained a contingent beneficial conversion feature that was recognized in the three months ending September 30, 2017 upon the July 2017 Stockholder Approval, which eliminated the contingency. As a result, $0.6 million was recorded as a reduction to Additional Paid in Capital and was considered a deemed dividend, increasing net loss attributable to Amyris, Inc. common stockholders.

 

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As of December 31, 2018, 89,528 shares of Series B Preferred Stock (including the Series B Preferred Stock issued in the August 2017 DSM Offering) have been converted into common stock (with the Make-Whole Payment in each case being made in the form of common stock) and 6,376 shares of Series B Preferred Stock were outstanding. At December 31, 2017, 9,213 shares of Series B Preferred Stock were outstanding.

 

May 2017 Warrants

 

The Company issued to each investor in the May 2017 Offerings warrants to purchase a number of shares of common stock equal to 100% of the shares of common stock into which such investor's shares of Series A Preferred Stock or Series B Preferred Stock were initially convertible (including shares of common stock issuable as payment of dividends or the Make-Whole Payment, assuming that all such dividends and the Make-Whole Payment are made in common stock), representing warrants to purchase 14,768,380 shares of common stock in the aggregate for all investors (collectively, the May 2017 Cash Warrants). The exercise price of the May 2017 Cash Warrants is subject to standard adjustments as well as full-ratchet anti-dilution protection for any issuance by the Company of equity or equity-linked securities during the three-year period following the issuance of such warrants (May 2017 Dilution Period) at a per share price less than the then-current exercise price of the May 2017 Cash Warrants, subject to certain exceptions. As of December 31, 2017, the exercise prices of the May 2017 Cash Warrants were $4.40 per share and no May 2017 Cash Warrants had been exercised. As of December 31, 2018, the exercise prices of the May 2017 Cash Warrants were $4.40 per share and 8,523,560 May 2017 Cash Warrants had been exercised (see “April 2018 Warrant Transactions” and “August 2018 Warrant Transactions” above).

 

In addition, the Company issued to each investor a warrant, with an exercise price of $0.0015 per share as of December 31, 2018 (collectively, the May 2017 Dilution Warrants), to purchase a number of shares of common stock sufficient to provide the investor with full-ratchet anti-dilution protection for any issuance by the Company of equity or equity-linked securities during the May 2017 Dilution Period at a per share price less than $6.30, the effective per share price paid by the investors for the shares of common stock issuable upon conversion of their Series A Preferred Stock or Series B Preferred Stock (including shares of common stock issuable as payment of dividends or the Make-Whole Payment, assuming that all such dividends and the Make-Whole Payment are made in common stock) subject to certain exceptions. As of December 31, 2018, the May 2017 Dilution Warrants were exercisable for an aggregate of 6,377,466 shares based on an effective per share price of $4.40 per share, of which 6,329,488 warrants had been exercised, resulting in a $64.1 million reduction in derivative liability. See “April 2018 Warrant Transactions” and “August 2018 Warrant Transactions” above regarding the cancellation of certain May 2017 Dilution Warrants.

 

The May 2017 Warrants each have a term of five years from the date such warrants initially became exercisable upon the receipt and effectiveness of the July 2017 Stockholder Approval. The exercise of the May 2017 Warrants (other than the May 2017 Warrants held by DSM) is subject to the May 2017 Offerings Beneficial Ownership Limitation. In connection with the entry by the Company and Foris into a warrant exercise agreement in August 2018 and related transactions (see “August 2018 Warrant Transactions” above), the Company and Foris amended Foris’s May 2017 Cash Warrants and May 2017 Dilution Warrant to remove the May 2017 Offerings Beneficial Ownership Limitation from such warrants. The May 2017 Cash Warrants are freestanding financial instruments that are accounted for as derivative liabilities and recognized at their fair value on the date of issuance of $39.5 million. As of December 31, 2018, the fair value of the May 2017 Cash Warrants was $24.1 million, as determined with the assistance of an independent third-party appraisal.

 

For the years ended December 31, 2018 and 2017, the Company recorded a loss of $13.5 million and $40.4 million, respectively, to reflect change in fair value of the May 2017 Cash Warrants (including the anti-dilution protection feature). Subsequent changes to the fair value of the May 2017 Cash Warrants will continue to be recorded in earnings until the warrants are exercised or expire in July 2022.

 

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July 2017 Stockholder Approval

 

In connection with the May 2017 Offerings, the Company agreed to solicit from its stockholders (i) any approval required by the rules and regulations of the NASDAQ Stock Market, including without limitation for the issuance of common stock upon conversion of the Series A Preferred Stock in excess of the May 2017 Exchange Cap, upon conversion of the Series B Preferred Stock and upon exercise of the May 2017 Warrants (the NASDAQ Approval) and (ii) approval to effect the Reverse Stock Split (collectively, the July 2017 Stockholder Approval) at an annual or special meeting of stockholders to be held on or prior to July 10, 2017, and to use commercially reasonable efforts to secure the July 2017 Stockholder Approval. The Reverse Stock Split was approved by the Company’s stockholders in May 2017 and the NASDAQ Approval was obtained on July 7, 2017.

 

August 2017 DSM OfferingRelated Party

 

On August 7, 2017, the Company issued and sold the following securities to DSM in a private placement (August 2017 DSM Offering):

  25,000 shares of Series B Preferred Stock (August 2017 DSM Series B Preferred Stock) at a price of $1,000 per share;
  a warrant to purchase 3,968,116 shares of common stock at an initial exercise price of $6.30 per share expiring in five years (August 2017 DSM Cash Warrant); and
  the August 2017 DSM Dilution Warrant (as described below).

 

Net proceeds to the Company were $25.9 million after payment of offering expenses and the allocation of total fair value received to the elements in the arrangement.

 

The exercise price of the August 2017 DSM Cash Warrant is subject to standard adjustments as well as full-ratchet anti-dilution protection for any issuance by the Company of equity or equity-linked securities during the three-year period following August 7, 2017 (DSM Dilution Period) at a per share price less than the then-current exercise price of the August 2017 DSM Cash Warrant, subject to certain exceptions. As of December 31, 2018, the exercise price of the August 2017 DSM Cash Warrant was $4.40 per share.

 

The August 2017 DSM Dilution Warrant allows DSM to purchase a number of shares of common stock sufficient to provide DSM with full-ratchet anti-dilution protection for any issuance by the Company of equity or equity-linked securities during the DSM Dilution Period at a per share price less than $6.30, the effective per share price paid by DSM for the shares of common stock issuable upon conversion of its Series B Preferred Stock (including shares of common stock issuable as payment of dividends or the Make-Whole Payment (as defined below), assuming that all such dividends and the Make-Whole Payment are made in common stock), subject to certain exceptions and subject to a price floor of $0.10 per share (Dilution Floor). The August 2017 DSM Dilution Warrant expires five years from the date it is initially exercisable.

 

In connection with the August 2017 DSM Offering, the Company also agreed that, subject to certain exceptions, it would not (i) issue any shares of common stock or securities convertible into or exercisable or exchangeable for common stock prior to October 31, 2017, (ii) effect any issuance of securities involving a variable rate transaction until May 11, 2018 or (iii) issue any shares of common stock or securities convertible into or exercisable or exchangeable for common stock at a price below the Dilution Floor without DSM's consent. On November 19, 2018, the Company entered into an agreement to reduce the exercise price of the August 2017 DSM Cash Warrant from $6.30 to $4.40 to compensate DSM for failure to obtain its consent to reduce the exercise price of the Vivo Warrant discussed in the “August 2018 Warrant Transactions” section of this Note 7 “Stockholders’ Deficit”. The Company determined the fair value of this agreement to be $6.8 million and recorded a legal settlement expense for the period ended December 31, 2018 in that amount. See Note 4, "Fair Value Measurement" for additional information. The accounting treatment for this transaction was evaluated in conjunction with the other November 2018 transactions discussed in Note 11, “Related Party Transactions”. Also, upon execution of this agreement the August 2017 DSM Dilution Warrant became exercisable for 1,713,565 shares based on an effective per share price of $0.0001 per share, all of which were exercised in November 2018.

 

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In connection with the August 2017 DSM Offering, the Company and DSM also entered into an amendment to the stockholder agreement dated May 11, 2017 (DSM Stockholder Agreement) between the Company and DSM (Amended and Restated DSM Stockholder Agreement). Under the DSM Stockholder Agreement, DSM was granted the right to designate one director selected by DSM, subject to certain restrictions and a minimum beneficial ownership level of 4.5%, to the Board. Furthermore, DSM has the right to purchase additional shares of capital stock of the Company in connection with a sale of equity or equity-linked securities by the Company in a capital raising transaction for cash, subject to certain exceptions, to maintain its proportionate ownership percentage in the Company. Pursuant to the DSM Stockholder Agreement, DSM agreed not to sell or transfer any of the Series B Preferred Stock or warrants purchased by DSM in the May 2017 Offerings (as defined below), or any shares of common stock issuable upon conversion or exercise thereof, other than to its affiliates, without the consent of the Company through May 2018 and to any competitor of the Company thereafter. DSM also agreed that, subject to certain exceptions, until three months after there is no DSM director on the Board, DSM will not, without the prior consent of the Board, acquire common stock or rights to acquire common stock that would result in DSM beneficially owning more than 33% of the Company’s outstanding voting securities at the time of acquisition. Under the DSM Stockholder Agreement, the Company agreed to use its commercially reasonable efforts to register, via one or more registration statements filed with the Securities and Exchange Commission (SEC) under the Securities Act of 1933, as amended (Securities Act), the shares of common stock issuable upon conversion or exercise of the securities purchased by DSM in the May 2017 Offerings. The Amended and Restated DSM Stockholder Agreement provides that (i) DSM has the right to designate a second director to the Board, subject to certain restrictions and a minimum beneficial ownership level of 10%, and (ii) the shares of common stock issuable upon conversion or exercise of the securities purchased by DSM in the August 2017 DSM Offering are (a) entitled to the registration rights provided for in the DSM Stockholder Agreement and (b) subject to the transfer restrictions set forth in the DSM Stockholder Agreement.

 

In addition, pursuant to the Amended and Restated DSM Stockholder Agreement, the Company and DSM agreed to negotiate in good faith regarding an agreement concerning the development of certain products in the Health & Wellness field and, in the event that the parties did not reach such agreement prior to 90 days after the closing of the August 2017 DSM Offering (August 2017 DSM Closing), (a) certain exclusive negotiating rights granted to DSM in connection with the entry into the DSM Stockholder Agreement would expire and (b) on the first anniversary of the August 2017 DSM Closing and each subsequent anniversary thereof, the Company would make a $5.0 million cash payment to DSM, provided that the aggregate amount of such payments would not exceed $25.0 million. In September 2017, the Company and DSM entered into such agreement, and in connection therewith an intellectual property escrow agreement relating to certain intellectual property licenses granted by the Company to DSM upon the August 2017 DSM Closing became effective.

 

In connection with the August 2017 DSM Offering and its $25.9 million in net proceeds, the Company also entered into a separate intellectual property license with DSM for consideration of $9.0 million in cash, which DSM remitted to the Company on October 28, 2017, and a credit letter (DSM Credit Letter) to be applied against future collaboration and royalty payments owed by DSM to the Company beginning in 2018. The DSM Credit Letter had a fair value of $7.1 million and was recorded as deferred revenue on the transaction date. The total fixed consideration of $34.0 million was allocated to each of the August 2017 DSM Series B Preferred Stock, August 2017 DSM Cash Warrant, August 2017 DSM Dilution Warrant and DSM Credit Letter at fair value based on level 3 inputs. The August 2017 DSM Series B Preferred Stock was recognized at its fair value on the date of issuance of $15.6 million, net of issuance costs of $0.2 million. The August 2017 Make-Whole Payment met the criteria to be classified in permanent equity and was not bifurcated from the preferred stock but will be recognized as a deemed dividend upon conversion, increasing the net loss attributable to Amyris, Inc. common stockholders. The August 2017 DSM Cash Warrant and August 2017 DSM Dilution Warrant are freestanding financial instruments and were initially recognized at their fair value of $10.6 million. The August 2017 DSM Cash Warrant and August 2017 DSM Dilution Warrant have been reported together as derivative liabilities. Changes in the fair value of the warrant derivatives for the years ended December 31, 2018 and 2017 have been recorded in earnings as a $7.5 million loss and $4.0 million loss, respectively.

 

As of December 31, 2018, all the August 2017 Series B Preferred Shares have been converted into common stock.

 

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The DSM Credit Letter was initially recorded as deferred revenue at its $7.1 million fair value, which was determined based on the assumptions that DSM would realize its credit over the next 18 months to 4 years with a 50% to 90% likelihood the credit will be utilized, fully discounted at the Company's 8.6% average cost of debt. After allocating the $34.0 million in fixed consideration to the financial instruments noted above and the DSM Credit Letter, $7.8 million was available for recognition as revenue related to the intellectual property licenses delivered to DSM, of which $3.3 million was recognized as license revenue during the year ended December 31, 2017. The DSM Credit Letter was terminated in December 2017, resulting in the reversal of the remaining unrecognized $4.5 million deferred revenue liability previously recorded as consideration for the DSM License and Collaboration transaction. See Note 10, “Revenue Recognition” for additional information.

 

August 2017 Vivo OfferingRelated Party

 

On August 3, 2017, the Company issued and sold the following securities to Vivo in a private placement (August 2017 Vivo Offering), resulting in net proceeds to the Company of $24.8 million after payment of offering expenses.

  2,826,711 shares of common stock at a price of $4.26 per share;
  12,958 shares of Series D Preferred Stock at a price of $1,000 per share;
  warrants to purchase an aggregate of 5,575,118 shares of common stock at an initial exercise price of $6.39 per share, expiring in five years (August 2017 Vivo Cash Warrants); and
  the August 2017 Vivo Dilution Warrants (as described below).

 

Each share of Series D Preferred Stock has a stated value of $1,000 and, subject to the August 2017 Vivo Offering Beneficial Ownership Limitation (as defined below), is convertible at any time, at the option of the holders, into common stock at a conversion price of $4.26 per share. The Series D Conversion Rate is subject to adjustment in the event of any dividends or distributions of the common stock, or any stock split, reverse stock split, recapitalization, reorganization or similar transaction.

 

Prior to declaring any dividend or other distribution of its assets to holders of common stock, the Company shall first declare a dividend per share on the Series D Preferred Stock equal to $0.0001 per share. In addition, the Series D Preferred Stock will be entitled to participate with the common stock on an as-converted basis with respect to any dividends or other distributions to holders of common stock. There were no dividends declared as of December 31, 2018 or 2017.

 

Unless and until converted into common stock in accordance with its terms, the Series D Preferred Stock has no voting rights, other than as required by law or with respect to matters specifically affecting the Series D Preferred Stock. The Series D Preferred Stock is classified as permanent equity, as the Company controls all actions or events required to settle the optional conversion feature in shares.

 

The August 2017 Vivo Cash Warrants and August 2017 Vivo Dilution Warrants are freestanding derivative instruments in connection with the issuance of equity instruments, which have been recorded as derivative liabilities. These warrants were recognized at their initial fair value upon issuance of $13.0 million as determined by management with the assistance of an independent third party appraisal based on level 3 inputs. Changes in the fair value of these derivative liabilities from the date of issuance through December 31, 2018 have been recorded in earnings, with losses of $7.7 million and $3.0 million recorded for the years ended December 31, 2018 and 2017, respectively. The remaining $12.0 million of the $25.0 million in gross proceeds received was allocated on a relative fair value basis, resulting in $5.6 million of proceeds, net of $0.2 million in issuance costs being allocated to the common stock sold in the August 2017 Vivo Offering and $6.2 million allocated to the Series D Preferred Stock. The Series D Preferred Stock includes a beneficial conversion feature of $5.8 million as the full fair value of the Series D Preferred Stock of $12.0 million was greater than the $6.2 million allocated to the Series D Preferred Stock. The $5.8 million beneficial conversation feature was recorded as a reduction to Additional Paid in Capital and a deemed dividend increasing net loss attributable to Amyris, Inc. common stockholders upon conversion in the third quarter of 2017.

 

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At December 31, 2018 and 2017, 8,280 and 12,958 shares, respectively of Series D Preferred Stock were outstanding. In the third quarter of 2018 Vivo converted 4,678 shares of August 2017 Offerings Series D Preferred Stock and the Company recognized a $6.8 million deemed dividend for the unamortized discounts created from the allocation of proceeds, as a reduction to Additional Paid in Capital and increasing net loss attributable to Amyris, Inc. common stockholders.

 

In the event of a Fundamental Transaction, the holders of the Series D Preferred Stock will have the right to receive the consideration receivable as a result of such Fundamental Transaction by a holder of the number of shares of common stock for which the Series D Preferred Stock is convertible immediately prior to such Fundamental Transaction (without regard to whether such Series D Preferred Stock is convertible at such time), which amount shall be paid pari passu with all holders of common stock. A Fundamental Transaction is defined in the Certificate of Designation of Preferences, Rights and Limitations relating to the Series D Preferred Stock as any of the following: (i) merger with or consolidation into another legal entity; (ii) sale, lease, license, assignment, transfer or other disposition of all or substantially all of the Company’s assets in one or a series of related transactions; (iii) purchase offer, tender offer or exchange offer of the Company’s common stock pursuant to which holders of the Company’s common stock are permitted to sell, tender or exchange their shares for other securities, cash or property and has been accepted by the holders of 50% or more of the outstanding common stock; (iv) reclassification, reorganization or recapitalization of the Company’s stock; or (v) stock or share purchase agreement that results in another party acquiring more than 50% of the Company’s outstanding shares of common stock.

 

Upon any liquidation, dissolution or winding-up of the Company, the holders of the Series D Preferred Stock shall be entitled to receive out of the assets of the Company the same amount that a holder of common stock would receive if the Series D Preferred Stock were fully converted to common stock immediately prior to such liquidation, dissolution or winding-up (without regard to whether such Series D Preferred Stock is convertible at such time), which amount shall be paid pari passu with all holders of common stock.

 

The conversion of the Series D Preferred Stock is subject to a beneficial ownership limitation of 9.99% (August 2017 Vivo Offering Beneficial Ownership Limitation), which limitation may be waived by the holders on 61 days’ prior notice.

 

The exercise price of the August 2017 Vivo Cash Warrants is subject to standard adjustments as well as full-ratchet anti-dilution protection for any issuance by the Company of equity or equity-linked securities during the three-year period following August 3, 2017 (Vivo Dilution Period) at a per share price less than the then-current exercise price of the August 2017 Vivo Cash Warrants, subject to certain exceptions. In connection with the entry by the Company and Vivo into warrant exercise agreements in August 2018 and related transactions (see “August 2018 Warrant Transactions” above), the Company and Vivo amended the August 2017 Vivo Cash Warrants to (i) reduce the exercise price of such warrants from $6.39 per share to $4.40 per share and (ii) remove the August 2017 Vivo Offering Beneficial Ownership Limitation from such warrants.

 

The August 2017 Vivo Dilution Warrants allow Vivo to purchase a number of shares of common stock sufficient to provide Vivo with full-ratchet anti-dilution protection for any issuance by the Company of equity or equity-linked securities during the Vivo Dilution Period at a per share price less than $4.26, the effective per share price paid by Vivo for the shares of common stock issuable upon conversion of the Series D Preferred Stock, subject to certain exceptions and subject to the Dilution Floor. The August 2017 Vivo Dilution Warrants expire five years from the date they are initially exercisable.

 

As of December 31, 2017, none of the August 2017 Vivo Warrants were exercised. As of December 31, 2018, 5,575,118 of the August 2017 Vivo Cash Warrants had been exercised and the August 2017 Vivo Dilution Warrants were not exercisable for any shares upon cancellation as part of the August 2018 transaction. See “August 2018 Warrant Transactions” above regarding the exercise of the August 2017 Vivo Cash Warrants and the cancellation of the August 2017 Vivo Dilution Warrants.

 

In connection with the August 2017 Vivo Offering, the Company agreed that it would not issue any shares of common stock or securities convertible into or exercisable or exchangeable for common stock at a price below the Dilution Floor without Vivo's consent.

 

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In connection with the August 2017 Vivo Offering, the Company and Vivo also entered into a Stockholder Agreement (Vivo Stockholder Agreement) setting forth certain rights and obligations of Vivo and the Company. Pursuant to the Vivo Stockholder Agreement, Vivo will have the right, subject to certain restrictions and a minimum beneficial ownership level of 4.5%, to (i) designate one director selected by Vivo to the Board and (ii) appoint a representative to attend all Board meetings in a nonvoting observer capacity and to receive copies of all materials provided to directors, subject to certain exceptions. Furthermore, Vivo will have the right to purchase additional shares of capital stock of the Company in connection with a sale of equity or equity-linked securities by the Company in a capital raising transaction for cash, subject to certain exceptions, to maintain its proportionate ownership percentage in the Company. Vivo agreed not to sell or transfer any of the shares of common stock, Series D Preferred Stock or warrants purchased by Vivo in the August 2017 Vivo Offering, or any shares of common stock issuable upon conversion or exercise thereof, other than to its affiliates, without the consent of the Company through August 2018 and to any competitor of the Company thereafter. Vivo also agreed that, subject to certain exceptions, until the later of (i) three years from the closing of the August 2017 Vivo Offering and (ii) three months after there is no Vivo director on the Board, Vivo will not, without the prior consent of the Board, acquire common stock or rights to acquire common stock that would result in Vivo beneficially owning more than 33% of the Company’s outstanding voting securities at the time of acquisition. Under the Vivo Stockholder Agreement, the Company agreed to use its commercially reasonable efforts to register, via one or more registration statements filed with the SEC under the Securities Act, the shares of common stock purchased in the August 2017 Vivo Offering as well as the shares of common stock issuable upon conversion or exercise of the Series D Preferred Stock and warrants purchased by Vivo in the August 2017 Vivo Offering.

 

May 2017 Exchange of Common Stock for Series C Convertible Preferred Stock - Related Party

 

In May 2017, Foris and Naxyris agreed to exchange (May 2017 Exchange) their outstanding shares of common stock, representing a total of 1,394,706 shares, for 20,921 shares of the Company's Series C Convertible Preferred Stock, par value $0.0001 per share (Series C Preferred Stock) in a private exchange.

 

Each share of Series C Preferred Stock had a stated value of $1,000 and would automatically convert into common stock, at a conversion price of $15.00 per share (Series C Conversion Rate), upon the approval by the Company's stockholders and implementation of a reverse stock split.

 

The shares of Series C Preferred Stock automatically converted to common stock on June 6, 2017 in connection with the effectiveness of the Reverse Stock Split. The Company accounted for the Series C Preferred Stock and the May 2017 Exchange as a non-monetary transaction that had no impact on the consolidated financial statements.

 

July 2015 PIPE Warrants

 

In July 2015, the Company entered into a securities purchase agreement with certain purchasers, including entities affiliated with members of the Board, under which the Company agreed to sell 1,068,379 shares of common stock at a price of $23.40 per share, for aggregate proceeds to the Company of $25.0 million. In connection with the sale, the Company granted to each of the purchasers a warrant, exercisable at a price of $0.15 per share, to purchase of a number of shares of common stock equal to 10% of the shares of common stock purchased by such investor. As of December 31, 2018 and 2017, such warrants had been exercised with respect to 25,643 shares of common stock and warrants with respect to 81,197 shares of common stock were outstanding.

 

For information regarding issuances of equity securities subsequent to December 31, 2018, see Part II, Item 8, “Subsequent Events”.

 

Right of First Investment to Certain Investors

 

In connection with investments in the Company has granted certain investors, including Vivo and DSM, a right of first investment if the Company proposes to sell securities in certain financing transactions. With these rights, such investors may subscribe for a portion of any such new financing and require the Company to comply with certain notice periods, which could discourage other investors from participating in, or cause delays in its ability to close, such a financing.

 

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8. Net Loss per Share Attributable to Common Stockholders

 

The Company computes net loss per share in accordance with ASC 260, “Earnings per Share.” Basic net loss per share of common stock is computed by dividing the Company’s net loss attributable to Amyris, Inc. common stockholders by the weighted-average number of shares of common stock outstanding during the period. Diluted net loss per share of common stock is computed by giving effect to all potentially dilutive securities, including stock options, restricted stock units, convertible preferred stock, convertible promissory notes and common stock warrants, using the treasury stock method or the as converted method, as applicable. For the years ended December 31, 2018 and 2017, basic net loss per share was the same as diluted net loss per share because the inclusion of all potentially dilutive securities outstanding was anti-dilutive. As such, the numerator and the denominator used in computing both basic and diluted net loss were the same for those years.

 

The Company follows the two-class method when computing net loss per common share when shares are issued that meet the definition of participating securities. The two-class method requires income available to common stockholders for the period to be allocated between common stock and participating securities based upon their respective rights to receive dividends as if all income for the period had been distributed. The two-class method also requires losses for the period to be allocated between common stock and participating securities based on their respective rights if the participating security contractually participates in losses. The Company’s convertible preferred stock are participating securities as they contractually entitle the holders of such shares to participate in dividends and contractually require the holders of such shares to participate in the Company’s losses.

 

The following table presents the calculation of basic and diluted net loss per share of common stock attributable to Amyris, Inc. common stockholders:

 

Years Ended December 31,
(In thousands, except shares and per share amounts)
  2018   2017
            (As Restated, Note 2)
Net loss attributable to Amyris, Inc.     (230,235 )     (155,982 )
Less deemed dividend related to beneficial conversion feature on Series A preferred stock           (562 )
Less deemed dividend related to beneficial conversion feature on Series B preferred stock           (634 )
Less deemed dividend related to beneficial conversion feature on Series D preferred stock           (5,757 )
Less deemed dividend upon settlement of make-whole provision on Series A preferred stock           (10,505 )
Less deemed dividend upon settlement of make-whole provision on Series B preferred stock           (22,632 )
Less deemed dividend related to the recognition of discounts on Series A preferred stock upon conversion           (21,578 )
Less deemed dividend related to the recognition of discounts on Series B preferred stock upon conversion           (24,366 )
Less deemed dividend related to proceeds discount upon conversion of Series D preferred stock     (6,852 )      
Add: losses allocated to participating securities     13,991       40,159  
Net loss attributable to Amyris, Inc. common stockholders   $ (223,096 )   $ (201,857 )
                 
Denominator:                
Weighted-average shares of common stock outstanding used in computing net loss per share of common stock, basic and diluted     60,405,910       32,253,570  
Basic and diluted loss per share   $ (3.69 )   $ (6.26 )

 

The following outstanding shares of potentially dilutive securities were excluded from the computation of diluted net loss per share of common stock for the periods presented because including them would have been anti-dilutive:

 

Years Ended December 31,   2018   2017
        (As Restated, Note 2)
Period-end common stock warrants     25,986,370       29,921,844  
Convertible promissory notes (1)     13,703,162       8,203,821  
Period-end stock options to purchase common stock     5,392,269       1,338,367  
Period-end restricted stock units     5,294,848       685,007  
Period-end preferred shares on an as-converted basis     2,955,732       4,504,212  
Total potentially dilutive securities excluded from computation of diluted net loss per share     53,332,381       44,653,251  

______________

  (1) The potentially dilutive effect of convertible promissory notes was computed based on conversion ratios in effect at the respective year-end. A portion of the convertible promissory notes issued carries a provision for a reduction in conversion price under certain circumstances, which could potentially increase the dilutive shares outstanding. Another portion of the convertible promissory notes issued carries a provision for an increase in the conversion rate under certain circumstances, which could also potentially increase the dilutive shares outstanding.

 

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9. Commitments and Contingencies

 

Lease Obligations

 

The Company leases certain facilities and finances certain equipment under operating and capital leases, respectively. Operating leases include leased facilities, and capital leases include leased equipment (see Note 3, "Balance Sheet Details"). The Company recognizes rent expense on a straight-line basis over the noncancelable lease term and records the difference between cash rent payments and the recognition of rent expense as a deferred rent liability. Where leases contain escalation clauses, rent abatements, and/or concessions, such as rent holidays and landlord or tenant incentives or allowances, the Company applies them as straight-line rent expense over the lease term. The Company has noncancelable operating lease agreements for office, research and development, and manufacturing space that expire at various dates, with the latest expiration in May 2023. Rent expense under operating leases was $5.8 million and $5.1 million for the years ended December 31, 2018 and 2017, respectively.

 

Future minimum payments under the Company's lease obligations as of December 31, 2018, are as follows:

 

Years Ending December 31
(In thousands)
  Capital
Leases
  Operating
Leases
  Total Lease
Obligations
2019   $ 513     $ 10,416     $ 10,929  
2020     198       7,932       8,130  
2021     1       7,226       7,227  
2022           7,399       7,399  
2023           3,034       3,034  
Thereafter                  
Total future minimum payments     712     $ 36,007     $ 36,719  
Less: amount representing interest     (33 )                
Present value of minimum lease payments     679                  
Less: current portion     (484 )                
Long-term portion   $ 195                  

 

Guarantor Arrangements

 

The Company has agreements whereby it indemnifies its executive officers and directors for certain events or occurrences while the executive officer or director is serving in his or her official capacity. The indemnification period remains enforceable for the executive officer's or director’s lifetime. The maximum potential amount of future payments the Company could be required to make under these indemnification agreements is unlimited; however, the Company has a director and officer insurance policy that limits its exposure and enables the Company to recover a portion of any future payments. As a result of its insurance policy coverage, the Company believes the estimated fair value of these indemnification agreements is minimal. Accordingly, the Company had no liabilities recorded for these agreements as of December 31, 2018 and 2017.

 

The GACP Term Loan Facility (see Note 5, "Debt" and Note 16, “Subsequent Events”) is collateralized by first-priority liens on substantially all of the Company's assets, including Company intellectual property. Certain of the Company’s subsidiaries have guaranteed the Company’s obligations under the GACP Term Loan Facility.

 

The Nikko Note is collateralized by a first-priority lien on 10% of the Aprinnova JV interests owned by the Company, as discussed in Note 5, "Debt".

 

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Other Matters

 

Certain conditions may exist as of the date the financial statements are issued, which may result in a loss to the Company but will only be recorded when one or more future events occur or fail to occur. The Company's management assesses such contingent liabilities, and such assessment inherently involves an exercise of judgement. In assessing loss contingencies related to legal proceedings that are pending against and by the Company or unasserted claims that may result in such proceedings, the Company's management evaluates the perceived merits of any legal proceedings or unasserted claims as well as the perceived merits of the amount of relief sought or expected to be sought.

 

If the assessment of a contingency indicates that it is probable that a material loss has been incurred and the amount of the liability can be estimated, then the estimated liability would be accrued in the Company's financial statements. If the assessment indicates that a potential material loss contingency is not probable but is reasonably possible, or is probable but cannot be reasonably estimated, then the nature of the contingent liability, together with an estimate of the range of possible loss if determinable and material would be disclosed. Loss contingencies considered to be remote by management are generally not disclosed unless they involve guarantees, in which case the guarantee would be disclosed.

 

On April 3, 2019, a securities class action complaint was filed against Amyris and our CEO, John G. Melo, and former CFO (and current Chief Business Officer), Kathleen Valiasek, in the U.S. District Court for the Northern District of California. The complaint seeks unspecified damages on behalf of a purported class that would comprise all persons and entities that purchased or otherwise acquired our securities between March 15, 2018 and March 19, 2019. The complaint alleges securities law violations based on statements and omissions made by the Company during such period. Subsequent to the filing of the securities class action complaint described above, on June 21, 2019, a purported shareholder derivative complaint was filed in the U.S. District Court for the Northern District of California (Bonner v. Doerr, et al., Case No. 4:19-cv-03621) based on similar allegations to those made in the securities class action complaint described above. The derivative complaint names Amyris, Inc. as a nominal defendant and names a number of the Company’s current and former officers and directors as additional defendants. The lawsuit seeks to recover, on the Company's behalf, unspecified damages purportedly sustained by the Company in connection with allegedly misleading statements and/or omissions made in connection with the Company’s securities filings. The derivative complaint also seeks a series of changes to the Company’s corporate governance policies, restitution to the Company from the individual defendants, and an award of attorneys’ fees. These cases are in the initial pleadings stage. We believe the complaints lack merit, and intend to defend ourselves vigorously. Given the early stage of these proceedings, it is not yet possible to reliably determine any potential liability that could result from these matters.

 

The Company is subject to disputes and claims that arise or have arisen in the ordinary course of business and that have not resulted in legal proceedings or have not been fully adjudicated. Such matters that may arise in the ordinary course of business are subject to many uncertainties and outcomes are not predictable with reasonable assurance and therefore an estimate of all the reasonably possible losses cannot be determined at this time. Therefore, if one or more of these legal disputes or claims resulted in settlements or legal proceedings that were resolved against the Company for amounts in excess of management’s expectations, the Company’s consolidated financial statements for the relevant reporting period could be materially adversely affected.

 

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10. Revenue Recognition

 

Disaggregation of Revenue

 

The following tables present revenue by primary geographical market, based on the location of the customer, as well as by major product and service:

 

Years Ended December 31,
(In thousands)
  2018   2017
        (As Restated, Note 2)
Europe   $ 29,405     $ 23,823  
United States     26,241       78,286  
Asia     6,331       23,290  
Brazil     942       2,159  
Other     685       113  
    $ 63,604     $ 127,671  

 

Significant Revenue Agreements

 

For the years ended December 31, 2018 and 2017, the Company recognized revenue in connection with significant revenue agreements and from all other customers as follows:

 

Years Ended December 31,
(In thousands)
  2018   2017 (As Restated, Note 2)
    Renewable Products   Licenses and Royalties   Grants and Collaborations   TOTAL   Renewable Products   Licenses and Royalties   Grants and Collaborations   TOTAL
Revenue from significant revenue agreements with:                                                                
DSM (related party)   $ 18     $ 5,958     $ 4,735     $ 10,711     $     $ 57,972     $ 1,679     $ 59,651  
Firmenich     3,727       1,700       5,717       11,144       9,621       1,199       5,803       16,623  
DARPA                 8,436       8,436                   12,333       12,333  
Givaudan     4,078             4,358       8,436       1,950             6,000       7,950  
Nenter                             12,057       2,633             14,690  
Ginkgo                                   (13,113 )           (13,113 )
Subtotal revenue from significant revenue agreements     7,823       7,658       23,246       38,727       23,628       48,691       25,815       98,134  
Revenue from all other customers     25,775             (898 )     24,877       18,742       12       10,783       29,537  
Total revenue from all customers   $ 33,598     $ 7,658     $ 22,348     $ 63,604     $ 42,370     $ 48,703     $ 36,598     $ 127,671  

 

Renewable Products

 

Firmenich Agreements

 

In 2013, the Company entered into a collaboration agreement with Firmenich SA (Firmenich) (as amended, the Firmenich Collaboration Agreement), for the development and commercialization of multiple renewable flavors and fragrances compounds. In 2014, the Company entered into a supply agreement with Firmenich (Firmenich Supply Agreement) for compounds developed under the Firmenich Collaboration Agreement. The Firmenich Collaboration Agreement and Firmenich Supply Agreement (Firmenich Agreements) are considered for revenue recognition purposes to comprise a single multiple-element arrangement.

 

In July 2017, the Company and Firmenich entered into an amendment of the Firmenich Collaboration Agreement, pursuant to which the parties agreed to exclude certain compounds from the scope of the agreement and to amend certain terms connected with the supply and use of such compounds when commercially produced. In addition, the parties agreed to (i) fix at a 70/30 basis (70% for Firmenich) the ratio at which the parties will share profit margins from sales of two compounds; (ii) set at a 70/30 basis (70% for Firmenich) the ratio at which the parties will share profit margins from sales of a distinct form of compound until Firmenich receives $15.0 million more than the Company in the aggregate from such sales, after which time the parties will share the profit margins 50/50 and (iii) a maximum Company cost of a compound where a specified purchase volume is satisfied, and alternative production and margin share arrangements in the event such Company cost cap is not achieved.

 

In August 2018, the Company and Firmenich entered into a second supply agreement (Firmenich Amended and Restated Supply Agreement), which incorporates all previous amendments and new changes and supersedes the September 2014 supply agreement. With this Amended and Restated Supply Agreement, the parties agreed on the compounds to be supplied under the agreement and the commercial specifications of these products, and made some adjustments to the pricing of the compounds.

 

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Pursuant to the Firmenich Collaboration Agreement, the Company agreed to pay a one-time success bonus to Firmenich of up to $2.5 million if certain commercialization targets are met. Such targets have not yet been met as of December 31, 2018. The one-time success bonus will expire upon termination of the Firmenich Collaboration Agreement, which has an initial term of 10 years and will automatically renew at the end of such term (and at the end of any extension) for an additional 3-year term unless otherwise terminated. At December 31, 2018, the Company had a $0.5 million liability associated with this one-time success bonus that has been recorded as a reduction to the associated collaboration revenue.

 

Nenter Agreements

 

In April 2016, the Company and Nenter & Co., Inc. (Nenter) entered into a renewable farnesene supply agreement (Nenter Supply Agreement) under which the Company agreed to supply farnesene and provide certain exclusive purchase rights, and Nenter committed to purchase minimum quantities and make quarterly royalty payments to the Company representing a portion of Nenter's profit on the sale of products produced using farnesene purchased under the agreement. The agreement expires December 31, 2020 and will automatically renew for an additional five years unless otherwise terminated. In December 2017, the Company assigned the Nenter Supply Agreement to DSM in connection with the Company's sale of its subsidiary Amyris Brasil Ltda., which owned and operated the Brotas, Brazil production facility; see Note 13, "Divestiture" and Note 11, "Related Party Transactions" for additional information.

 

Licenses and Royalties

 

DSM Agreements

 

DSM July and September 2017 Collaboration and Licensing Agreements

 

In July and September 2017, the Company entered into three separate collaboration agreements with DSM (DSM Collaboration Agreements) to jointly develop three new molecules in the Health & Wellness (DSM Ingredients) market using the Company’s technology, which the Company would produce and DSM would commercialize. Pursuant to the DSM Collaboration Agreements, DSM will, subject to certain conditions, provide funding for the development of the DSM Ingredients and, upon commercialization, the parties would enter into supply agreements whereby DSM would purchase the applicable DSM Ingredients from the Company at prices agreed by the parties. The development services will be directed by a joint steering committee with equal representation by DSM and the Company. In addition, the parties will share profit margin from DSM’s sales of products that incorporate the DSM Ingredients subject to the DSM Collaboration Agreements.

 

In connection with the entry into the DSM Collaboration Agreements, the Company and DSM also entered into certain license arrangements (DSM License Agreements) providing DSM with certain rights to use the technology underlying the development of the DSM Ingredients to produce and sell products incorporating the DSM Ingredients. Under the DSM License Agreements, DSM agreed to pay the Company $9.0 million for a worldwide, exclusive, perpetual, royalty-free license to produce and sell products incorporating one of the DSM Ingredients in the Health & Wellness field.

 

As discussed in Note 7, “Stockholders’ Deficit”, the Company received $34.0 million of fixed consideration resulting from the August 2017 DSM Offering and the DSM License Agreements, discussed above, and allocated this consideration to the various elements identified. The Company first allocated $10.6 million to the August 2017 DSM Cash Warrants and DSM Dilution Warrants liabilities and $15.6 million of the proceeds to the August 2017 DSM Series B Preferred Stock. The remaining proceeds in excess of the fair value the equity awards and warrants of $7.8 million was available for recognition as revenue generated from the delivery of the intellectual property licenses to DSM.

 

In connection with the entry into the DSM Agreements, the Company and DSM entered into the DSM Credit Letter, pursuant to which the Company granted a credit to DSM in an aggregate amount of $12.0 million to be offset against future collaboration payments (in an amount not to exceed $6.0 million) and royalties receivable from DSM beginning in 2018.  The $7.8 million available for revenue recognition was reduced by an apportionment of the credit and allocated between delivered license revenue and future revenues associated with the collaboration agreements. This resulted in the recognition of $3.3 million in licenses revenue under the DSM License Agreements and the remaining amount of $4.5 million being recorded as deferred revenue. During the three months ended December 31, 2017, the Company and DSM terminated the DSM Credit Letter, eliminating the $12.0 million credit from the DSM Collaboration Agreements. As a result of the cancelation of the Credit Letter, the $4.5 million of deferred revenue was included as an element of consideration in the series of December 2017 DSM agreements described below, which were evaluated as a combined transaction for accounting purposes in conjunction with the sales of the Brotas 1 facility discussed more fully in Note 11, "Related Party Transactions" and Note 13, "Divestiture".

 

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DSM Value Sharing Agreement

 

In December 2017, in conjunction with the Company's divestiture of its Brotas, Brazil production facility (see Note 13, "Divestiture" and Note 11, "Related Party Transactions"), the Company and DSM entered into a value sharing agreement (Value Sharing Agreement), pursuant to which DSM agreed to make certain royalty payments to the Company representing a portion of the profit on the sale of products produced using farnesene purchased under the Nenter Supply Agreement realized by Nenter and paid to DSM in accordance with the Nenter Supply Agreement. In addition, pursuant to the Value Sharing Agreement, DSM agreed to guarantee certain minimum annual royalty payments for the first three calendar years of the Value Sharing Agreement, subject to future offsets in the event that the royalty payments to which the Company would otherwise have been entitled under the Value Sharing Agreement for such years fall below certain milestones. The fair value of the nonrefundable minimum annual royalty payments were determined to be fixed and determinable, and were included as part of the total arrangement consideration subject to allocation of the overall multiple-element transaction that occurred in December 2017 with DSM. Under the Value Sharing Agreement, the Company is required to use certain royalty payments received by the Company with respect to the first three calendar years of the Value Sharing Agreement in excess of the guaranteed minimum annual royalty payments for such years, if any, to repay amounts outstanding under the DSM Credit Agreement; however, in 2018, the Company did not receive royalty payments in excess of the guaranteed minimum annual amount. See Note 5, "Debt". The Value Sharing Agreement will expire in December 2027, subject to the right of each of the parties to terminate for uncured material breach by the other party or in the event the other party is subject to bankruptcy proceedings, liquidation, dissolution or similar proceedings or other specified events. During 2018, the Company and DSM amended the Value Sharing Agreement to (i) provide for the use of estimates in calculating quarterly royalty payments (subject to true-up), (ii) modify how the guaranteed minimum annual royalty payment for 2018 will be offset against value payments accruing during 2018 and (iii) accelerate the minimum annual royalty payment for 2019 from December 31, 2018 to June 30, 2018 in exchange for a fee of $750,000. For the year ended December 31, 2018, the Company recognized $7.9 million of revenue in connection with the DSM Value Sharing Agreement.

 

In April 2019, the Company assigned to DSM all the Company’s rights and obligations under the Value Sharing Agreement. See Note 16, “Subsequent Events” for additional information.

 

DSM Performance Agreement

 

In December 2017, in connection with the Company's divestiture of its Brotas, Brazil production facility (see Note 13, "Divestiture"), the Company and DSM entered into a performance agreement (Performance Agreement), pursuant to which the Company will provide certain research and development services to DSM relating to the development of the technology underlying the farnesene-related products to be manufactured at the Brotas facility in exchange for related funding, including certain bonus payments in the event that specific performance metrics are achieved. The Company will record the bonus payments as earned revenue upon the transfer of the developed technology to DSM. If the Company does not meet the established metrics under the Performance Agreement, the Company will be required to pay $1.8 million to DSM. The Performance Agreement will expire in December 2020, subject to the right of each of the parties to terminate for uncured material breach by the other party or in the event the other party is subject to bankruptcy proceedings, liquidation, dissolution or similar proceedings or other specified events.

 

In April 2019, the Company and DSM amended the Performance Agreement. See Note 16, “Subsequent Events” for additional information.

 

DSM November 2017 Intellectual Property License Agreement

 

In November 2017, in connection with the Company's divestiture of its Brotas, Brazil production facility (see Note 13, "Divestiture"), the Company and DSM entered into a license agreement covering certain intellectual property of the Company useful in the performance of certain commercial supply agreements assigned by the Company to DSM relating to products currently manufactured at the Brotas facility (DSM November 2017 Intellectual Property License Agreement). In December 2017, DSM paid the Company an upfront license fee of $27.5 million. In accounting for the Divestiture with DSM, a multiple-element arrangement, the license of intellectual property to DSM was identified as revenue deliverable with standalone value and qualified as a separate unit of accounting. The Company performed an analysis to determine the fair value for of the license, and allocated the non-contingent consideration based on the relative fair value. The Company determined that the license had been fully delivered, and, as such, license revenue of $54.6 million was recognized for the period ended December 31. 2017.

 

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DSM December 2017 Supply Agreement and November 2018 Supply Agreement Amendment

 

On November 19, 2018, the Company and DSM entered into an amendment (Supply Agreement Amendment) to the supply agreement, dated December 28, 2017 (Supply Agreement), by and between the Company and DSM. Under the Supply Agreement, DSM agreed to manufacture and supply to the Company certain products useful in the Company’s business, at prices and on production and delivery terms and specifications set forth in the Supply Agreement, which prices are based upon DSM’s manufacturing cost plus an agreed margin. The Supply Agreement originally provided that it would expire (i) with respect to non-farnesene related products, on the date that the Company’s planned new specialty ingredients manufacturing facility in Brazil is fully operational and meets its production targets, but in any event no later than December 31, 2021 and (ii) with respect to farnesene related products, on December 28, 2037, subject in each case to earlier termination in certain circumstances. Pursuant to the Supply Agreement Amendment, (i) the outside expiration date of the Supply Agreement with respect to non-farnesene related products was extended to December 31, 2022, with specified pricing terms added for products manufactured during 2022, (ii) DSM committed to produce certain non-farnesene related products for the Company for two months of each calendar year during the term of the Supply Agreement and (iii) the Company agreed to (A) pay DSM a cash fee totaling $15.5 million, payable in installments during 2018 and 2019, (B) issue 1,643,991 shares of the Company's common stock to DSM, and (C) pay DSM a cash fee of $7.3 million, payable on or before March 29, 2019, plus, if the closing price of the Common Stock on the trading day immediately preceding the date of such payment is less than $4.41 per share, an amount equal to such deficiency multiplied by 1,643,991.

 

The Company also entered into other transactions with DSM in November 2018 which resulted in the Company (i) accounting for this series of transactions, including the Supply Agreement Amendment, and certain other transactions with DSM in 2018 as a combined arrangement, and (ii) determining and allocating the fair value to each element. See Note 11, “Related Party Transactions” for additional information.

 

In April 2019, the Company and DSM further amended the Supply Agreement. See Note 16, “Subsequent Events” for additional information.

 

DSM November 2018 Letter Agreement

 

On November 19, 2018, the Company and DSM entered into a letter agreement (November 2018 DSM Letter Agreement), pursuant to which the Company agreed (i) to cause the removal of certain existing liens on intellectual property owned by the Company and licensed to DSM and (ii) if such liens were not removed prior to December 15, 2018, to issue to DSM shares of the Company’s common stock with a value equal to $5.0 million. On December 14, 2018, the Company entered into an amendment to the GACP Term Loan Facility to remove such lien, and the November 2018 DSM Letter Agreement was thereby terminated.

 

Ginkgo Agreements

 

Ginkgo Initial Strategic Partnership Agreement and Collaboration Agreement

 

In June 2016, the Company entered into a collaboration agreement (Initial Ginkgo Agreement) with Ginkgo Bioworks, Inc. (Ginkgo), pursuant to which the Company licensed certain intellectual property to Ginkgo in exchange for a fee of $20.0 million to be paid by Ginkgo to the Company in two installments, and a 10% royalty on net revenue, including without limitation net sales, royalties, fees and any other amounts received by Ginkgo related directly to the license. The Company received the first installment of $15.0 million in July 2016, which the Company recognized as revenue in 2016. However, the Company did not receive the second installment of $5.0 million, as the Company did not meet the milestone criteria for the receipt of such payment.

 

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In September 2016, the Company and Ginkgo entered into a collaboration agreement (Ginkgo Collaboration Agreement) setting forth the terms of the Ginkgo Collaboration, under which the parties would collaborate to develop, manufacture and sell commercial products, and Ginkgo would pay royalties to the Company. The Ginkgo Collaboration Agreement provided that, subject to certain exceptions, all third-party contracts for the development of chemical small molecule compounds whose manufacture is enabled by the use of microbial strains and fermentation technologies that are entered into by the Company or Ginkgo during the term of the Ginkgo Collaboration Agreement would be subject to the Ginkgo Collaboration and the approval of the other party (not to be unreasonably withheld). Responsibility for the engineering and small-scale process development of the newly developed products would be allocated between the parties on a project-by-project basis, and the Company would be principally responsible for the commercial scale-up and production of such products, with each party generally bearing its own respective costs and expenses relating to the Ginkgo Collaboration, including capital expenditures.

 

Under the Ginkgo Collaboration Agreement, subject to certain exceptions, including excluded or refused products and cost savings initiatives, the profit on the sale of products subject to the Ginkgo Collaboration Agreement as well as cost-sharing, milestone and “value-creation” payments associated with the development and production of such products would be shared equally between the parties. The parties also agreed to provide each other with a license and other rights to certain intellectual property necessary to support the development and manufacture of the products under the Ginkgo Collaboration, and also to provide each other with access to certain other intellectual property useful in connection with the activities to be undertaken under the Ginkgo Collaboration Agreement, subject to certain carve-outs.

 

Ginkgo Partnership Agreement

 

In November 2017, the Company and Ginkgo entered into a partnership agreement (Ginkgo Partnership Agreement) to replace and supersede the Ginkgo Collaboration Agreement. Under the Ginkgo Partnership Agreement, the Company and Ginkgo agreed:

  to continue to collaborate on limited research and development;
  to provide each other licenses (with royalties) to specified intellectual property for limited purposes;
  for the Company to pay Ginkgo quarterly fees of $0.8 million (Partnership Payments) for a total of $12.7 million, beginning on December 31, 2018 and ending on September 30, 2022;
  to share profit margins from sales of a certain product to be developed under the Ginkgo Partnership Agreement on a 50/50 basis, subject to certain conditions, provided that net profits will be payable to Ginkgo for any quarterly period to the extent that such net profits exceed the sum of (a) quarterly interest payments due under the November 2017 Ginkgo Note (see Note 5, "Debt") and (b) Partnership Payments due in such quarter;

 

  for the Company to issue the $12 million Ginkgo Note which effectively guarantees Ginkgo $12 million minimum future royalties under the profit margin sharing provisions noted above; and

 

  for the Company to pay Ginkgo $0.5 million in connection with certain fees previously owed to Ginkgo under the Ginkgo Collaboration Agreement.

 

The Ginkgo Partnership Agreement provides for an initial term of two years and will automatically renew for successive one-year terms thereafter unless otherwise terminated. The Company does not expect to recognize any future revenue under this arrangement.

 

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The Company recorded the $6.1 million present value of the $12.7 million partnership payments as an other liability (see Note 3, "Balance Sheet Details"), with the remaining $6.6 million recorded as a debt discount to be recognized as interest expense under the effective interest method over the five-year payment term. The Company also concluded the partnership payment obligation under the Ginkgo Partnership Agreement represents consideration payable to a former customer; and consequently, the present value of the partnership payments should be recorded as a reduction of cumulative revenue recognized to date from Ginkgo in the period the partnership agreement was executed. As a result, the Company recorded a $6.1 million reduction in license revenues for the year ended December 31, 2017. The Company reached a similar conclusion regarding the $12.0 million Ginkgo Note (see Note 5, "Debt" under the “Ginkgo Note” section for further discussion regarding the accounting treatment of the Ginkgo Note) and recorded an additional $7.0 million reduction in license revenue for the year ended December 31, 2017 related to the present value of the Ginkgo Note. In total, the Company recorded a $13.1 million reduction in licenses and royalties revenue and $13.1 million in notes payable and other liabilities as of and for the year ended December 31, 2017 upon execution of the Ginkgo Partnership Agreement.

 

Collaborations

 

DARPA Technology Investment Agreement

 

In September 2015, the Company entered into a technology investment agreement (TIA) with The Defense Advanced Research Projects Agency (DARPA), under which the Company, with the assistance of specialized subcontractors, is working to create new research and development tools and technologies for strain engineering and scale-up activities. The agreement is being funded by DARPA on a milestone basis. Under the TIA, the Company and its subcontractors could collectively receive DARPA funding of up to $35.0 million over the program’s four year term if all of the program’s milestones are achieved. In conjunction with DARPA’s funding, the Company and its subcontractors are obligated to collectively contribute approximately $15.5 million toward the program over its four year term (primarily by providing specified labor and/or purchasing certain equipment). For the DARPA agreement, the Company recognizes revenue using an output-based measure of progress of the milestones completed relative to remaining milestones, once acknowledged by DARPA.

 

Contract Assets and Liabilities

 

When a contract results in revenue being recognized in excess of the amount the Company has invoiced or has the right to invoice to the customer, a contract asset is recognized. Contract assets are transferred to accounts receivable, net when the rights to the consideration become unconditional. Contract assets are presented as Accounts receivable, unbilled – related party on the consolidated balance sheets.

 

Contract liabilities consist of payments received from customers, or such consideration that is contractually due, in advance of providing the product or performing services such that control has not passed to the customer.

 

Trade receivables related to revenue from contracts with customers are included in accounts receivable on the consolidated balance sheets, net of the allowance for doubtful accounts. Trade receivables are recorded at the point of renewable product sale or in accordance with the contractual payment terms for licenses and royalties, and grants and collaborative research and development services for the amount payable by the customer to the Company for sale of goods or the performance of services, and for which the Company has the unconditional right to receive payment.

 

Contract Balances

 

The following table provides information about accounts receivable and contract liabilities from contracts with customers:

 

December 31,
(In thousands)
  2018  2017
Accounts receivable, net  $16,003   $18,953 
Accounts receivable - related party, net  $1,349   $4,767 
Accounts receivable, unbilled - related party  $8,021   $9,901 
Accounts receivable, unbilled, noncurrent - related party  $1,203   $7,940 
Contract liabilities(1)  $8,236   $4,308 
Contract liabilities, noncurrent(2)  $1,587   $ 

 

(1)     The balance in contract liabilities, current at December 31, 2017 represents deferred revenue, current prior to the Company's adoption of ASC 606, "Revenue".

(2)     The balances in contract liabilities, noncurrent are included in other noncurrent liabilities on the consolidated balance sheets. 

 

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Unbilled receivables relate to the Company’s right to consideration from DSM for (i) minimum future royalties and (ii) a material right arising from a customer option for a future transfer of technology. The Company’s right to cash receipt for these minimum royalty amounts occurs on or before December 31, 2019, and the right to cash receipt for the customer option occurs on or before December 31, 2020.

 

Contract liabilities, current increased by $3.9 million at December 31, 2018 resulting from a $0.8 million increase upon adoption of ASC 606 on January 1, 2018 plus the net amount of collaboration and royalty revenues invoiced in excess of amounts recognized as revenue, less $3.3 million of revenue recognized during the year ended December 31, 2018 that was included in deferred revenue at the beginning of the period.

 

Remaining Performance Obligations

 

The following table provides information regarding the estimated revenue expected to be recognized in the future related to performance obligations that are unsatisfied (or partially unsatisfied) based on the Company's existing agreements with customers as of December 31, 2018.

 

(In thousands)   As of December 31, 2018
2019   $ 14,131  
2020     7,925  
2021      
2022 and thereafter      
Total from all customers   $ 22,056  

 

In accordance with the disclosure provisions of ASC 606, the table above excludes estimated future revenues for performance obligations that are part of a contract that has an original expected duration of one year or less or a performance obligation with variable consideration that is recognized using the sales-based royalty exception for licenses of intellectual property. Additionally, $21.4 million of estimated future revenue is excluded from the table above, as that amount represents constrained variable consideration.

 

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11. Related Party Transactions

 

Related Party Divestiture

 

See Note 13, “Divestiture” for details regarding the sale of Amyris Brasil to DSM in December 2017.

 

Related Party Equity

 

See Note 7, "Stockholders' Deficit" for details of these related party equity transactions:

    November 2018 DSM Securities Purchase Agreement

    August 2018 Warrant Transactions

    August 2017 DSM Offering

    May 2017 Offerings

    May 2017 Exchange of Common Stock for Series C Convertible Preferred Stock

    July 2015 PIPE Warrants

    Temasek Funding Warrant

 

Related Party Debt

 

See Note 5, "Debt" for details of these related party debt transactions:

    DSM Note (also see Note 13, "Divestiture")

    February 2016 Private Placement

    2014 Rule 144A Convertible Notes

    August 2013 Financing Convertible Notes

    R&D Note

 

 

Related party debt was as follows:

 

December 31,
(in thousands)
  2018   2017
    Principal   Unamortized
Debt
(Discount)
Premium
  Net   Principal   Unamortized
Debt
(Discount)
Premium
  Net
Total                        
2014 Rule 144A convertible notes   $ 9,705     $ (422 )   $ 9,283     $ 9,705     $ (1,538 )   $ 8,167  
August 2013 financing convertible notes                       21,711       897       22,608  
R&D note                       3,700       (18 )     3,682  
      9,705       (422 )     9,283       35,116       (659 )     34,457  
DSM                                                
DSM note     25,000       (6,311 )     18,689       25,000       (8,039 )     16,961  
Other DSM loan                       393             393  
      25,000       (6,311 )     18,689       25,393       (8,039 )     17,354  
Biolding                                                
February 2016 private placement                       2,000             2,000  
                                                 
Foris                                                
2014 Rule 144A convertible notes     5,000       (181 )     4,819       5,000       (660 )     4,340  
                                                 
Temasek                                                
2014 Rule 144A convertible notes     10,000       (435 )     9,565       10,000       (1,591 )     8,409  
    $ 49,705     $ (7,349 )   $ 42,356     $ 77,509     $ (10,949 )   $ 66,560  

 

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The fair value of the derivative liabilities related to the related party R&D Note, related party August 2013 Financing Convertible Notes (Tranche Notes) and related party 2014 Rule 144A Convertible Notes as of December 31, 2018 and 2017 was $0 and $0.2 million, respectively. The Company recognized (losses) gains from change in the fair value of these derivative liabilities of ($8.5) million and $0.6 million for the years ended December 31, 2018 and 2017, respectively; see Note 4, "Fair Value Measurement".

 

At December 31, 2018, Temasek was no longer a related party. However, the Company and Temasek were related parties when they entered into the 2014 Rule 144A convertible notes transaction, for which terms have remained unchanged since the borrowing date.

 

Related Party Revenue

 

The Company recognized revenue from related parties and from all other customers as follows:

 

Years Ended December 31,
(In thousands)
  2018   2017 (As restated, Note 2)
    Renewable Products   Licenses and Royalties   Grants and Collaborations   TOTAL   Renewable Products   Licenses and Royalties   Grants and Collaborations   TOTAL
Revenue from related parties:                                                                
DSM   $ 18     $ 5,958     $ 4,735     $ 10,711     $     $ 57,972     $ 1,679     $ 59,651  
Total     342                   342       (200 )                 (200 )
Novvi                             1,491                   1,491  
Subtotal revenue from related parties     360       5,958       4,735       11,053       1,291       57,972       1,679       60,942  
Revenue from all other customers(1)     33,238       1,700       17,613       52,551       41,079       (9,269 )     34,919       66,729  
Total revenue from all customers   $ 33,598     $ 7,658     $ 22,348     $ 63,604     $ 42,370     $ 48,703     $ 36,598     $ 127,671  

 

  (1) Licenses and royalties revenue is negative for 2017 due to the $13.1 million reversal of cumulative to date revenue as a result of entering into the 2017 Ginkgo Partnership Agreement. See Note 10. Revenue Recognition.

 

See Note 10, "Revenue Recognition" for details of the Company's revenue agreements with DSM.

 

Related Party Accounts Receivable

 

Related party accounts receivable was as follows:

 

December 31,
(In thousands)
  2018   2017
DSM   $ 1,071     $ 12,823  
Novvi     188       1,607  
Total     90       238  
Related party accounts receivable, net   $ 1,349     $ 14,668  

 

In addition to the amounts shown above, there were the following amounts on the consolidated balance sheet at December 31, 2018:

 

    a total of $8.0 million of unbilled receivables from DSM, in the lines captioned “Accounts receivable, unbilled - related party” and “Accounts receivable, unbilled, noncurrent - related party”; and

 

    $4.3 million of contingent consideration receivable from DSM in the line captioned "Other assets".

 

Related Party Accounts Payable

 

Amounts due to DSM that were included in Accounts payable and Accrued and other current liabilities at December 31, 2018 were $2.1 million and $0.6 million, respectively.

 

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Related Party DSM Transactions

 

The Company is party to the following significant agreements (and related amendments) with related party DSM:

 

Related to Agreement For Additional Information, See the Note Indicated
Debt DSM Credit Agreement 5. Debt
10. Revenue Recognition
Debt DSM Note 5. Debt
Debt November 2018 DSM Letter Agreement 5. Debt
Divestiture November 2017 Quota Purchase Agreement 13. Divestiture
Divestiture December 2017 DSM Transition Services Agreement 13. Divestiture
Equity May 2017 Offerings 7. Stockholders' Deficit
Equity August 2017 DSM Offering 7. Stockholders' Deficit
Equity November 2018 DSM Securities Purchase Agreement 7. Stockholders' Deficit
Revenue July and September 2017 Collaboration and Licensing Agreements 10. Revenue Recognition
Revenue December 2017 DSM Supply Agreement 10. Revenue Recognition
Revenue December 2017 DSM Value Sharing Agreement, as amended 10. Revenue Recognition
Revenue December 2017 DSM Performance Agreement 10. Revenue Recognition
Revenue November 2017 Intellectual Property License Agreement 10. Revenue Recognition
Revenue November 2018 Supply Agreement Amendment 10. Revenue Recognition

 

Concurrent with the sale of Amyris Brasil in December 2017, the Company and DSM entered into a series of commercial agreements including (i) a license agreement to DSM of its farnesene product for DSM to use in the Vitamin E and lubricant markets; (ii) a royalty agreement that DSM will pay the Company specified royalties representing a portion of the profit on the sale of Vitamin E produced from farnesene under the Nenter Supply Agreement assigned to DSM; (iii) a performance agreement, which provides an option for DSM to elect a technology transfer upon the achievement of certain development milestones associated with the optimization of farnesene strains; and (iv) a transition services agreement for the Company to provide finance, legal, logistics, and human resource services to support the Brotas facility under DSM ownership for a six-month period with a DSM option to extend for six additional months. At closing, DSM paid the Company a nonrefundable license fee of $27.5 million and a nonrefundable royalty payment of $15.0 million. In addition, in December 2017 the Company entered into a credit agreement with DSM under which the Company borrowed $25 million; see Note 5, "Debt" for additional information.

 

In June 2018, DSM paid the Company a non-refundable minimum royalty payment of $9.3 million (net of a $0.7 million early payment discount) and will also owe the Company a final payment of $8.1 million in 2019. The future nonrefundable minimum annual royalty payments were determined to be fixed and determinable with a fair value of $17.8 million and were included as part of the total arrangement consideration subject to allocation of this overall multiple-element divestiture transaction.

 

In November 2018, the Company amended the supply agreement with DSM to secure capacity at the Brotas 1 facility for Reb M production thru 2022. See Note 10, “Revenue Recognition” for information regarding the November 2018 Supply Agreement Amendment and the November 2018 DSM Securities Purchase Agreement. The Company also entered into other transactions with DSM in November 2018 which resulted in the Company (i) evaluating this series of November 2018 transactions and considering other certain transactions with DSM in 2018 as a combined arrangement, and (ii) determining and allocating the fair value to each element. The other transactions entered into concurrently with the November 2018 Supply Agreement Amendment and November 2018 DSM Securities Purchase Agreement included an agreement to finalize the working capital adjustments related to the Brotas 1 facility sale in December 2017 and an amendment to reduce the exercise price of the Cash Warrant issued to DSM in the August 2017 DSM Offering and to provide a waiver for any potential claims arising from failure to obtain consent prior to amending the exercise price of the August 2017 Vivo Cash Warrant in the August 2017 Warrant transaction.

 

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The contractual consideration transferred to DSM under the combined arrangement was $34.7 million. The Company performed an analysis to determine the fair value of the elements and allocated (i) $24.4 million to the manufacturing capacity, (ii) $6.8 million to the legal settlement and related consent waiver and (iii) $2.1 million to the working capital adjustment. Of the $24.4 million fair value allocated to the manufacturing capacity, $3.3 million was recorded as deferred cost of revenue during the period ended December 31, 2018 and the remaining $21.0 million will be recorded as deferred cost of revenue in the period the additional payments are due and payable to DSM. The deferred cost of revenue asset will be expensed on a units of production basis as products are sold over the five-year term of the supply agreement and evaluated for recoverability at each period end. The $6.8 million of fair value allocated to the legal settlement and related consent waiver was recorded as legal settlement expense for the year ended December 31, 2018. The $2.1 million of fair value allocated to the working capital adjustment was recorded as a loss on divestiture for the year ended December 31, 2018. The contractual consideration transferred to DSM exceeded the fair value of the elements received by $1.4 million and this excess was recorded as a reduction of licenses and royalties revenues in the three months ended December 31, 2018.

 

Related Party Joint Venture

 

In December 2016, the Company, Nikko Chemicals Co., Ltd. an existing commercial partner of the Company, and Nippon Surfactant Industries Co., Ltd., an affiliate of Nikko (collectively, Nikko) entered into a joint venture (the Aprinnova JV Agreement) pursuant to which the Company contributed certain assets, including certain intellectual property and other commercial assets relating to its business-to-business cosmetic ingredients business (the Aprinnova JV Business), as well as its Leland production facility. The Company also agreed to provide the Aprinnova JV with exclusive (to the extent not already granted to a third party), royalty-free licenses to certain of the Company's intellectual property necessary to make and sell products associated with the Aprinnova JV Business (the Aprinnova JV Products). Nikko purchased their 50% interest in the Aprinnova JV in exchange for the following payments to the Company: (i) an initial payment of $10.0 million and (ii) the profits, if any, distributed to Nikko in cash as members of the Aprinnova JV during the three-year period from 2017 to 2019, up to a maximum of $10.0 million.

 

The Aprinnova JV operates in accordance with the Aprinnova Operating Agreement under which the Aprinnova JV is managed by a Board of Directors consisting of four directors: two appointed by the Company and two appointed by Nikko. In addition, Nikko has the right to designate the Chief Executive Officer of the Aprinnova JV from among the directors and the Company has the right to designate the Chief Financial Officer. The Company determined that it has the power to direct the activities of the Aprinnova JV that most significantly impact its economic performance because of its (i) significant control and ongoing involvement in operational decision making, (ii) guarantee of production costs for certain Aprinnova JV products, as discussed below, and (iii) control over key supply agreements, operational and administrative personnel and other production inputs. The Company has concluded that the Aprinnova JV is a variable-interest entity (VIE) under the provisions of ASC 810, Consolidation, and that the Company has a controlling financial interest and is the VIE's primary beneficiary. As a result, the Company accounts for its investment in the Aprinnova JV on a consolidation basis in accordance with ASC 810.

 

Under the Aprinnova Operating Agreement, profits from the operations of the Aprinnova JV, if any, are distributed as follows: (i) first, to the Company and Nikko (the Members) in proportion to their respective unreturned capital contribution balances, until each Member’s unreturned capital contribution balance equals zero and (ii) second, to the Members in proportion to their respective interests. In addition, any future capital contributions will be made by the Company and Nikko on an equal (50%/50%) basis each time, unless otherwise mutually agreed.

 

Pursuant to the Aprinnova JV Agreement, the Company and Nikko agreed to make working capital loans to the Aprinnova JV in the amounts of $0.5 million and $1.5 million, respectively, as described in more detail in Note 5, “Debt” under “Aprinnova Working Capital Loans”. In addition, the Company agreed to guarantee a maximum production cost for squalane and hemisqualane to be produced by the Aprinnova JV and to bear any cost of production above such guaranteed costs.

 

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In connection with the contribution of the Leland Facility by the Company to the Aprinnova JV, at the closing of the formation of the Aprinnova JV, Nikko made a loan to the Company in the principal amount of $3.9 million, and the Company in consideration therefore issued a promissory note to Nikko in an equal principal amount, as described in more detail in Note 5, “Debt” under “Nikko Note.”

 

The following presents the carrying amounts of the Aprinnova JV’s assets and liabilities included in the accompanying consolidated balance sheets. Assets presented below are restricted for settlement of the Aprinnova JV's obligations and all liabilities presented below can only be settled using the Aprinnova JV resources.

 

December 31,
(In thousands)
  2018   2017
Assets   $ 12,904     $ 7,635  
Liabilities   $ 2,364     $ 3,187  

 

The Aprinnova JV's assets and liabilities are primarily comprised of inventory, property, plant and equipment, accounts payable and debt, which are classified in the same categories in the Company's consolidated balance sheets.

 

There was no change in noncontrolling interest for the Aprinnova JV for the years ended December 31, 2018 and 2017, due to profit sharing provisions whereby the Company retains 100% of the profits from 2017 to 2020.

 

Office Sublease

 

The Company subleases certain office space to Novvi, for which the Company charged Novvi $0.6 million and $0.5 million for the years ended December 31, 2018 and 2017, respectively.

 

See Note 16, “Subsequent Events” for information regarding related party transactions subsequent to December 31, 2018.

 

12. Stock-based Compensation

 

Stock-based Compensation Expense Related to All Plans

 

Stock-based compensation expense related to all employee stock compensation plans, including options, restricted stock units and ESPP, was as follows:

 

Years Ended December 31,
(In thousands)
  2018   2017
Research and development   $ 1,797     $ 2,204  
Sales, general and administrative     7,393       4,061  
Total stock-based compensation expense   $ 9,190     $ 6,265  

 

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Plans

 

2010 Equity Incentive Plan

 

The Company's 2010 Equity Incentive Plan (2010 Equity Plan) became effective on September 27, 2010 and will terminate in 2020. The 2010 Equity Plan provides for the granting of common stock options, restricted stock awards, stock bonuses, stock appreciation rights, restricted stock units (RSUs) and performance awards. It allows for time-based or performance-based vesting for the awards. Options granted under the 2010 Equity Plan may be either incentive stock options (ISOs) or non-statutory stock options (NSOs). ISOs may be granted only to Company employees (including officers and directors who are also employees). NSOs may be granted to Company employees, non-employee directors and consultants. The Company will be able to issue no more than 2,000,000 shares pursuant to the grant of ISOs under the 2010 Equity Plan. Options under the 2010 Equity Plan may be granted for periods of up to ten years. All options issued to date have had a ten-year life. Under the plan, the exercise price of any ISOs and NSOs may not be less than 100% of the fair market value of the shares on the date of grant. The exercise price of any ISOs and NSOs granted to a 10% stockholder may not be less than 110% of the fair value of the underlying stock on the date of grant. The options and RSUs granted to-date generally vest over three to five years.

 

As of December 31, 2018 and 2017, options were outstanding to purchase 5,339,214 and 1,255,045 shares, respectively, of the Company's common stock granted under the 2010 Equity Plan, with weighted-average exercise prices per share of $33.40 and $26.29, respectively. In addition, as of December 31, 2018 and 2017, restricted stock units representing the right to receive 5,294,803 and 683,554 shares, respectively, of the Company's common stock granted under the 2010 Equity Plan were outstanding. As of December 31, 2018 and 2017, 2,359,750 and 252,107 shares, respectively, of the Company’s common stock remained available for future awards that may be granted under the 2010 Equity Plan.

 

The number of shares reserved for issuance under the 2010 Equity Plan increases automatically on January 1 of each year starting with January 1, 2011, by a number of shares equal to 5% of the Company’s total outstanding shares as of the immediately preceding December 31. However, the Company’s Board of Directors or the Leadership Development and Compensation Committee of the Board of Directors retains the discretion to reduce the amount of the increase in any particular year.

 

In May 2018, shareholders approved amendments to the 2010 Equity Plan to (i) increase the number of shares of common stock available for grant and issuance thereunder by 9.0 million shares and (ii) increase the annual per-participant award limit thereunder to 4.0 million shares. Subsequent to the amendments, the total number of shares available for grant was 9,280,000, not including the annual evergreen increases.

 

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2005 Stock Option/Stock Issuance Plan

 

In 2005, the Company established its 2005 Stock Option/Stock Issuance Plan (2005 Plan) which provided for the granting of common stock options, restricted stock units, restricted stock and stock purchase rights awards to employees and consultants of the Company. The 2005 Plan allowed for time-based or performance-based vesting for the awards. Options granted under the 2005 Plan were ISOs or NSOs. ISOs were granted only to Company employees (including officers and directors who are also employees). NSOs were granted to Company employees, non-employee directors, and consultants.

 

All options issued under the 2005 Plan had a ten-year life. The exercise prices of ISOs and NSOs granted under the 2005 Plan were not less than 100% of the estimated fair value of the shares on the date of grant, as determined by the Board of Directors. The exercise price of an ISO and NSO granted to a 10% stockholder could not be less than 110% of the estimated fair value of the underlying stock on the date of grant as determined by the Board. The options generally vested over 5 years.

 

As of December 31, 2018 and 2017, options to purchase 52,389 and 79,322 shares, respectively, of the Company’s common stock granted under the 2005 Plan remained outstanding, and as a result of the adoption of the 2010 Equity Plan discussed above, zero shares of the Company’s common stock remained available for future awards issuance under the 2005 Plan. The options outstanding under the 2005 Plan as of December 31, 2018 and 2017 had a weighted-average exercise price per share of $185.93 and $144.58, respectively.

 

2010 Employee Stock Purchase Plan

 

The 2010 Employee Stock Purchase Plan (2010 ESPP) became effective on September 27, 2010. The 2010 ESPP is designed to enable eligible employees to purchase shares of the Company’s common stock at a discount. Offering periods under the 2010 ESPP generally commence on each May 16 and November 16, with each offering period lasting for one year and consisting of two six-month purchase periods. The purchase price for shares of common stock under the 2010 ESPP is the lesser of 85% of the fair market value of the Company’s common stock on the first day of the applicable offering period or the last day of each purchase period. During the life of the 2010 ESPP, the number of shares reserved for issuance increases automatically on January 1 of each year, starting with January 1, 2011, by a number of shares equal to 1% of the Company’s total outstanding shares as of the immediately preceding December 31. However, the Company’s Board of Directors or the Leadership Development and Compensation Committee of the Board of Directors retains the discretion to reduce the amount of the increase in any particular year. In May 2018, shareholders approved an amendment to the 2010 ESPP to increase the maximum number of shares of common stock that may be issued over the term of the ESPP by 1 million shares. No more than 1,666,666 shares of the Company’s common stock may be issued under the 2010 ESPP and no other shares may be added to this plan without the approval of the Company’s stockholders.

 

2018 CEO Performance-based Stock Options

 

In May 2018, the Company granted its chief executive officer performance-based stock options (PSOs) to purchase 3,250,000 shares. PSOs are equity awards with the final number of PSOs that may vest determined based on the Company’s performance against pre-established EBITDA milestones and Amyris stock price milestones. The EBITDA milestones are measured from the grant date through December 31, 2021, and the stock price milestones are measured from the grant date through December 31, 2022. The PSOs vest in four tranches contingent upon the achievement of both the EBITDA milestones and stock price milestones for each respective tranche, and the chief executive officer’s continued employment with the Company. Over the measurement periods, the number of PSOs that may be issued and the related stock-based compensation expense that is recognized is adjusted upward or downward based upon the probability of achieving the EBITDA milestones. Depending on the probability of achieving the EBITDA milestones and stock price milestones and certification of achievement of those milestones for each vesting tranche by the Company’s Board of Directors or Compensation Committee, the PSOs issued could be from zero to 3,250,000 stock options, with an exercise price of $5.08 per share.

 

Stock-based compensation expense for this award is recognized using a graded-vesting approach over the service period beginning at the grant date through December 31, 2022, as the Company’s management has determined that certain EBITDA milestones are probable of achievement over the next four years as of December 31, 2018, The Company utilized a Monte Carlo simulation to estimate the grant date fair value of each tranche of the award which totaled $5.1 million. For the year ended December 31, 2018, the Company recognized $0.7 million of compensation expense for this award. The assumptions used to estimate the fair value of this award with performance and market vesting conditions were as follows:

 

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Stock Option Award with Performance and Market Vesting Conditions:    
Fair value of the Company’s common stock on grant date   $ 5.08  
Expected volatility     70 %
Risk-free interest rate     2.75 %
Dividend yield     0.0 %

 

Stock Option Activity

 

Stock option activity is summarized as follows:

 

Year ended December 31,   2018   2017
Options granted     4,337,119       661,094  
Weighted-average grant-date fair value per share   $ 5.18     $ 3.26  
Compensation expense related to stock options (in millions)   $ 2.6     $ 3.3  
Unrecognized compensation costs as of December 31 (in millions)   $ 8.5     $ 2.7  

 

The Company expects to recognize the December 31, 2018 balance of unrecognized costs over a weighted-average period of 3.8 years. Future option grants will increase the amount of compensation expense to be recorded in these periods.

 

Stock-based compensation expense for stock options and employee stock purchase plan rights is estimated at the grant date and offering date, respectively, based on the fair-value using the Black-Scholes option pricing model. The fair value of employee stock options is amortized on a ratable basis over the requisite service period of the awards. The fair value of employee stock options and employee stock purchase plan rights was estimated using the following weighted-average assumptions:

 

Years Ended December 31,   2018   2017
Expected dividend yield     —%       —%  
Risk-free interest rate     2.8 %     2.1 %
Expected term (in years)     6.90       6.12  
Expected volatility     80 %     84 %

 

The expected life of options is based primarily on historical share option exercise experience of the employees for options granted by the Company. All options are treated as a single group in the determination of expected life, as the Company does not currently expect substantially different exercise or post-vesting termination behavior among the employee population. The risk-free interest rate is based on the U.S. Treasury yield for a term consistent with the expected life of the awards in effect at the time of grant. Expected volatility is based on the historical volatility of the Company's common stock. The Company has no history or expectation of paying dividends on common stock.

 

Stock-based compensation expense associated with options is based on awards ultimately expected to vest. At the time of an option grant, the Company estimates the expected future rate of forfeitures based on historical experience. These estimates are revised, if necessary, in subsequent periods if actual forfeiture rates differ from those estimates. If the actual forfeiture rate is lower than estimated the Company will record additional expense and if the actual forfeiture is higher than estimated the Company will record a recovery of prior expense.

 

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The Company’s stock option activity and related information for the year ended December 31, 2018 was as follows:

 

    Number of
Stock
Options
  Weighted-
average
Exercise
Price
  Weighted-average
Remaining
Contractual
Life

(in years)
  Aggregate
Intrinsic
Value

(in thousands)
Outstanding - December 31, 2017     1,338,367     $ 33.40       7.7     $ 97  
Options granted     4,337,119     $ 5.18                  
Options exercised     (70,807 )   $ 3.68                  
Options forfeited or expired     (214,409 )   $ 19.61                  
Outstanding - December 31, 2018     5,390,270     $ 11.55       8.5     $ 29  
Vested or expected to vest after December 31, 2018     4,833,615     $ 12.28       8.4     $ 28  
Exercisable at December 31, 2018     972,229     $ 39.73       5.8     $ 12  

 

The aggregate intrinsic value of options exercised under all option plans was $0.2 million and $0 for the years ended December 31, 2018 and 2017, respectively, determined as of the date of option exercise.

 

Restricted Stock Units Activity and Expense

 

During the years ended December 31, 2018 and 2017, 5,452,664 and 523,167 RSUs, respectively, were granted with weighted-average service-inception date fair value per unit of $5.36 and $5.51, respectively. The Company recognized RSU-related stock-based compensation expense of $6.4 million and $2.8 million, respectively, for the years ended December 31, 2018 and 2017. As of December 31, 2018 and 2017, unrecognized RSU-related compensation costs totaled $23.8 million and $5.0 million, respectively.

 

Stock-based compensation expense for RSUs is measured based on the closing fair market value of the Company's common stock on the date of grant.

 

The Company’s RSU and restricted stock activity and related information for the year ended December 31, 2018 was as follows:

 

    Number of
Restricted
Stock Units
  Weighted-
average
Grant-date
Fair Value
  Weighted-
average
Remaining
Contractual
Life
(in years)
Outstanding - December 31, 2017     683,554     $ 8.66       1.4  
Awarded     5,452,664     $ 5.36          
Vested     (445,828 )   $ 8.43          
Forfeited     (395,587 )   $ 5.64          
Outstanding - December 31, 2018     5,294,803     $ 5.50       1.7  
 Vested or expected to vest after December 31, 2018     4,953,264     $ 5.50       1.6  

 

ESPP Activity and Expense

 

During the years ended December 31, 2018 and 2017, 246,230 and 47,058 shares, respectively, of the Company's common stock were purchased under the 2010 ESPP. At December 31, 2018 and 2017, 382,824 and 80,594 shares, respectively, of the Company’s common stock remained reserved for issuance under the 2010 ESPP.

 

During the years ended December 31, 2018 and 2017, the Company also recognized ESPP-related stock-based compensation expense of $0.2 million and $0.1 million, respectively.

 

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13. Divestiture

 

On December 28, 2017, the Company completed the sale of its subsidiary Amyris Brasil Ltda. (Amyris Brasil), which operated the Company’s production facility located in Brotas, Brazil, to DSM and concurrently entered into a series of commercial agreements and a credit agreement with DSM. At closing, the Company received $33.0 million in contractual cash consideration for the capital stock of Amyris Brasil, which was subject to certain post-closing working capital adjustments; and reimbursements contingent upon DSM’s utilization of certain Brazilian tax benefits it acquired with its purchase of Amyris Brasil. The Company used $12.6 million of the cash proceeds received to repay certain indebtedness of Amyris Brasil. The total fair value of the contractual consideration received by the Company for Amyris Brasil was $56.9 million and resulted in a pretax gain of $5.7 million from continuing operations. In November 2018, the Company paid DSM $1.8 million related to the final post-closing working capital adjustment. In connection with the payment, $1.8 million was recorded as a loss on divestiture in the 2018 consolidated statement of operations, in the line captioned "(Loss) gain on divestiture".

 

Concurrent with the sale of Amyris Brasil, the Company and DSM entered into a series of commercial agreements including (i) a license agreement to DSM of its farnesene product for DSM to use in the Vitamin E and lubricant markets; (ii) a royalty agreement, pursuant to which DSM agreed to pay the Company specified royalties representing a portion of the profit on the sale of Vitamin E produced from farnesene sold under the Nenter Supply Agreement assigned to DSM; (iii) a performance agreement for the Company to perform research and development to optimize farnesene for production and sale of farnesene products; and (iv) a transition services agreement for the Company to provide finance, legal, logistics, and human resource services to support the Brotas facility under DSM ownership for a six-month period with a DSM option to extend for six additional months (see Note 10, “Revenue Recognition” and Note 16, “Subsequent Events” for additional information). At closing, DSM paid the Company a nonrefundable license fee of $27.5 million and a nonrefundable royalty payment of $15.0 million. DSM also paid the Company a nonrefundable minimum annual royalty payment in 2018 and will pay a nonrefundable minimum annual royalty payment in 2019. The future nonrefundable minimum annual royalty payments were determined to be fixed and determinable with a fair value of $17.8 million and were included as part of the total arrangement consideration subject to allocation of this overall multiple-element divestiture transaction. See Note 10, “Revenue Recognition” and Note 11, "Related Party Transactions" for a full listing and details of agreements entered into with DSM. Additionally, the Company and DSM entered into a $25.0 million credit agreement that the Company used to repay all outstanding amounts under the Guanfu Note; see Note 5, “Debt” for additional information.

 

The Company accounted for the sale of Amyris Brasil as a sale of a business for proceeds of $54.8 million. The agreements entered into concurrently with the sale of Amyris Brasil including the license agreement, royalty agreement, performance agreement, transition services agreement, and credit agreement contain various elements and, as such, are deemed to be an arrangement with multiple deliverables as defined under U.S. GAAP. The Company performed an analysis to determine the fair value for all elements in the agreements with DSM and separated the elements between the non-revenue and revenue elements. After allocating the total fair value of the non-revenue elements from the fixed and determinable consideration received, the Company allocated the remaining fixed and determinable consideration to the revenue elements based on relative fair value. As such, the Company recognized $54.7 million of license revenue and $2.1 million of deferred revenue related to the performance option and transition services agreements with DSM as of December 31, 2017.

 

Results from the operations of Amyris Brasil are included in the Company's Consolidated Statements of Operations for 2017, and the Company has not segregated the results of operations or net assets of Amyris Brasil on the Company's consolidated financial statements for any period presented. The disposition of the assets and liabilities of Amyris Brasil did not qualify for classification as a discontinued operation as it did not represent a strategic shift that will have a major effect on the Company’s operations and financial results.

 

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14. Income Taxes

 

The components of loss before income taxes are as follows:

 

Years Ended December 31,
(In thousands)
  2018   2017
        (As Restated, Note 2)
United States   $ (218,109 )   $ (156,020 )
Foreign     (12,125 )     6,915  
Loss before income taxes   $ (230,234 )   $ (149,105 )

 

The components of the provision for income taxes are as follows:

 

Years Ended December 31,
(In thousands)
  2018   2017
              (As Restated, Note 2)  
Current:                
Federal   $     $ 6,564  
State           18  
Foreign           964  
Total current provision           7,546  
Deferred:                
Federal           (669 )
State            
Foreign            
Total deferred benefit           (669 )
Total provision for income taxes$   $     $ 6,877  

 

A reconciliation between the statutory federal income tax and the Company’s effective tax rates as a percentage of loss before income taxes is as follows:

 

Years Ended December 31,   2018   2017
        (As Restated, Note 2)
Statutory tax rate     (21.0 )%     (34.0 )%
State taxes, net of federal tax benefit     %     %
Stock-based compensation     %     %
Federal R&D credit     (0.6 )%     (0.2 )%
Derivative liability     4.3 %     13.9 %
Nondeductible interest     1.0 %     3.0 %
Other     (0.1 )%     (0.2 )%
Foreign losses     0.9 %     8.5 %
Change in U.S. federal tax rate     %     25.1 %
IRC Section 382 limitation     %     7.2 %
Change in valuation allowance     15.5 %     (18.6 )%
Effective income tax rate     %     4.7 %

 

 

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Temporary differences and carryforwards that gave rise to significant portions of deferred taxes are as follows:

 

December 31,
(In thousands)
  2018   2017
        (As Restated, Note 2)
Net operating loss carryforwards   $ 57,921     $ 20,066  
Property, plant and equipment     9,269       9,653  
Research and development credits     12,046       9,480  
Foreign tax credit            
Accruals and reserves     8,526       7,286  
Stock-based compensation     6,496       5,471  
Disallowed interest carryforward     2,359        
Capitalized start-up costs            
Capitalized research and development costs     27,888       32,085  
Intangible and others     3,114       3,584  
Equity investments     156        
Total deferred tax assets     127,775       87,625  
Debt discount and derivatives     (3,750 )     (6,539 )
Total deferred tax liabilities     (3,750 )     (6,539 )
Net deferred tax assets prior to valuation allowance     124,025       81,086  
Less: valuation allowance     (124,025 )     (81,086 )
Net deferred tax assets   $     $  

 

Activity in the deferred tax assets valuation allowance is summarized as follows:

 

(In thousands)   Balance at Beginning
of Year
  Additions   Reductions /
Charges
  Balance at
End of Year
Deferred tax assets valuation allowance:                                
Year Ended December 31, 2018   $ 81,086     $ 42,939     $     $ 124,025  
Year Ended December 31, 2017 (As Restated, Note 2)   $ 386,867     $     $ (305,781 )   $ 81,086  

 

Recognition of deferred tax assets is appropriate when realization of such assets is more likely than not. Based on the weight of available evidence, especially the uncertainties surrounding the realization of deferred tax assets through future taxable income, the Company believes that it is more likely than not that the net deferred tax assets will not be fully realizable. Accordingly, the Company has provided a full valuation allowance against its net deferred tax assets as of December 31, 2018 and 2017. The valuation allowance decreased by $305.8 million during the year ended December 31, 2017 and increased by $42.9 million during the year ended December 31, 2018. The valuation allowance decreased by $305.8 million during the year ended December 31, 2017 due to the partial write-off of federal net operating loss (NOL) carryforwards due to the IRC Section 382 limitation further described below and due to tax reform that changed deferred tax asset rate from 35% down to 21%.

 

On December 22, 2017, the U.S. government enacted comprehensive tax legislation, commonly referred to as the Tax Cuts and Jobs Act (Tax Act). The Tax Act makes broad and complex changes to the U.S. tax code, including, but not limited to, (1) reducing the U.S. federal corporate tax rate from 35 percent to 21 percent; (2) requiring companies to pay a one-time transition tax on certain unrepatriated earnings of foreign subsidiaries; (3) generally eliminating U.S. federal income taxes on dividends from foreign subsidiaries; (4) requiring a current inclusion in U.S. federal taxable income of certain earnings of controlled foreign corporations; (5) eliminating the corporate alternative minimum tax (AMT) and changing how existing AMT credits can be realized; (6) creating the base erosion anti-abuse tax, a new minimum tax; (7) creating a new limitation on deductible interest expense; and (8) changing the rules related to uses and limitations of NOL carryforwards created in tax years beginning after December 31, 2017.

 

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On December 22, 2017, Staff Accounting Bulletin No. 118 (SAB 118) was issued to address the application of GAAP in situations when a registrant does not have the necessary information available, prepared or analyzed (including computations) in reasonable detail to complete the accounting for certain income tax effects of the Tax Act. In accordance with SAB 118, the Company recorded a provisional amount related to the remeasurement of certain deferred tax assets and liabilities based on the rates at which they are expected to reverse in the future, which resulted in a $37.7 million net decrease related to deferred tax assets and deferred tax liabilities, with a corresponding and fully offsetting adjustment to our valuation allowance for the year ended December 31, 2017. As of December 22, 2018, the Company completed its accounting for the remeasurement of certain deferred tax assets and liabilities based on the rates at which they are expected to reverse in the future. There have been no net benefit changes to the provisional estimates disclosed in the period of enactment under SAB 118. The Tax Act also created a new requirement that certain income (i.e., GILTI) earned by controlled foreign corporations (CFCs) must be included currently in the gross income of the CFCs' U.S. shareholder. The Company has elected to treat GILTI as a period cost in its income tax provision computations.

 

As of December 31, 2018, the Company had federal net operating loss carryforwards of approximately $290.7 million and state net operating loss carryforwards $154.3 million, available to reduce future taxable income, if any. The Internal Revenue Code of 1986, as amended, imposes restrictions on the utilization of net operating losses in the event of an “ownership change” of a corporation. Accordingly, a company’s ability to use net operating losses may be limited as prescribed under Internal Revenue Code Section 382 (IRC Section 382). Events that may cause limitations in the amount of the net operating losses that the Company may use in any one year include, but are not limited to, a cumulative ownership change of more than 50% over a three-year period. During the year ended December 31, 2017, the Company experienced a cumulative ownership change of greater than 50%. As such, net operating losses generated prior to that change are subject to an annual limitation on their use. Due to the limitations imposed, the Company wrote-off $456.2 million and $115.5 million of federal NOL and state NOL carryovers that are expected to expire before they can be utilized. Additionally, the Company wrote-off $14.7 million of its historical federal research and development credit carryovers as a result of the limitations. As of December 31, 2018, the Company had foreign net operating loss carryovers of $7.3 million.

  

As of December 31, 2018, the Company had federal research and development credit carryforwards of $1.6 million and California research and development credit carryforwards of $13.5 million.

 

If not utilized, the federal net operating loss carryforward will begin expiring in 2025, and the California net operating loss carryforward will begin expiring in 2028. The federal research and development credit carryforwards will expire starting in 2038 if not utilized. The California research and development credit carryforwards can be carried forward indefinitely.

 

A reconciliation of the beginning and ending amounts of unrecognized tax benefits is as follows:

 

 

(In thousands)    
Balance at December 31, 2016   $ 9,101  
Increases in tax positions for prior period     50  
Increases in tax positions during current period     19,682  
Balance at December 31, 2017     28,833  
Increases in tax positions for prior period     55  
Increases in tax positions during current period     1,239  
Balance at December 31, 2018   $ 30,127  

 

The Company’s policy is to include interest and penalties related to unrecognized tax benefits within the provision for taxes. The Company determined that accrual for interest and penalties was not material as of December 31, 2018 or 2017.

 

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None of the unrecognized tax benefits, if recognized, would affect the effective income tax rate for any of the above years due to the valuation allowance that currently offsets deferred tax assets. The Company does not anticipate that the total amount of unrecognized income tax benefits will significantly increase or decrease in the next 12 months.

 

The Company’s primary tax jurisdiction is the United States. For United States federal and state tax purposes, returns for tax years 2005 and forward remain open and subject to tax examination by the appropriate federal or state taxing authorities. Brazil tax years 2010 and forward remain open and subject to examination.

 

As of December 31, 2018, the U.S. Internal Revenue Service (the IRS) has completed its audit of the Company for tax year 2008 and concluded that there were no adjustments resulting from the audit. While the statutes are closed for tax year 2008, the U.S. federal tax carryforwards (net operating losses and tax credits) may be adjusted by the IRS in the year in which the carryforward is utilized.

 

15. Geographical Information

 

The chief operating decision maker is the Company's Chief Executive Officer, who makes resource allocation decisions and assesses performance based on financial information presented on a consolidated basis. There are no segment managers who are held accountable by the chief operating decision maker, or anyone else, for operations, operating results, and planning for levels or components below the consolidated unit level. Accordingly, the Company has determined that it has a single reportable segment and operating segment structure.

 

Revenue

 

Revenue by geography, based on each customer's location, is shown in Note 10, "Revenue Recognition".

 

Property, Plant and Equipment

 

December 31,
(In thousands)
  2018   2017
            (As Restated, Note 2)
United States   $ 13,111     $ 10,357  
Brazil     6,447       3,357  
Europe     198       178  
    $ 19,756     $ 13,892  

 

 

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16. Subsequent Events

 

Extension and Exchange of Tranche II Note

 

On January 14, 2019, Wolverine Flagship Fund Trading Limited (Wolverine) agreed to waive payment of the Tranche II Note held by Wolverine (see Note 5, “Debt”) at maturity until July 15, 2019 in exchange for a fee, payable on or prior to July 15, 2019, of $0.6 million. Effective July 15, 2019, the due date of the waiver fee was extended to October 13, 2019 and will bear interest at a rate of 1.75% per month, compounded, from July 16, 2019 to the date of payment.

 

Evergreen Shares for 2010 Equity Incentive Plan and 2010 Employee Stock Purchase Plan

 

In February 2019, the Company's Board of Directors (the Board) approved increases to the number of shares available for issuance under the Company's 2010 Equity Incentive Plan (the Equity Plan) and 2010 Employee Stock Purchase Plan (the Purchase Plan). These shares in connection with the Equity Plan represented an automatic annual increase in the number of shares available for grant and issuance under the Equity Plan of 3,828,241 shares. This increase is equal to approximately 5.0% of the 76,564,829 total outstanding shares of the Company’s common stock as of December 31, 2018. This automatic increase was effective as of January 1, 2019. These shares in connection with the Purchase Plan represented an automatic annual increase in the number of shares reserved for issuance under the Purchase Plan of 382,824 shares. This increase is equal to approximately 0.5% of the 76,564,829 total outstanding shares of the Company’s common stock as of December 31, 2018. This automatic increase was effective as of January 1, 2019.

 

Cannabinoid Agreement

 

On March 18, 2019, the Company entered into a $300 million research, collaboration and license agreement (the Cannabinoid Agreement) with LAVVAN, Inc., a newly formed investment-backed company (Lavvan), for the development, manufacture and commercialization of cannabinoids. Under the agreement, the Company would perform research and development activities and Lavvan would be responsible for the commercialization of the cannabinoids developed under the agreement. The Cannabinoid Agreement is being principally funded on a milestone basis, with the Company also entitled to receive certain supplementary research and development funding from Lavvan. The Company could receive aggregate funding of up to $300 million over the term of the Cannabinoid Agreement if all of the milestones are achieved. Additionally, the agreement provides for profit share to the Company on Lavvan's gross profit margin once products are commercialized; these payments will be due for the next 20 years. The consummation of the transactions contemplated by the Cannabinoid Agreement is subject to certain conditions, including obtaining certain third party consents and releases and the repayment or refinancing of the 2014 Rule 144A Convertible Notes and the 2015 Rule 144A Convertible Notes (see Note 5, “Debt”). On May 2, 2019, the parties consummated the transactions contemplated by the Cannabinoid Agreement, including the formation of a special purpose entity to hold certain intellectual property created during the collaboration (the Cannabinoid Collaboration IP), the licensing of certain Company intellectual property to Lavvan, the licensing of the Cannabinoid Collaboration IP to the Company and Lavvan, and the granting by the Company to Lavvan of a lien on the Company background intellectual property being licensed to Lavvan under the Cannabinoid Agreement, which lien would be subordinated to the lien on such intellectual property under the GACP Term Loan Facility (see Note 5, “Debt”).

 

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LSA Amendments, Assignment and Waivers

 

On April 4, 2019, the Company and GACP amended the LSA (see Note 5, “Debt”) to (i) effective December 31, 2018, eliminate the conditions giving rise to the early maturity date, so that loans under the GACP Term Loan Facilities would have a maturity date of July 1, 2021, (ii) remove certain Company intellectual property related to the Cannabinoid Agreement from the lien granted by the Company to GACP under the LSA, (iii) eliminate the Company’s ability to obtain the Incremental GACP Term Loan Facility, (iv) eliminate the Company’s reinvestment rights with respect to mandatory prepayments upon asset sales, (v) restrict the Company’s ability to pay interest and principal on other indebtedness without the consent of GACP, and (vi) provide that the Company must have at all times at least $15 million of unrestricted, unencumbered cash subject to a control agreement in favor of GACP.

 

On April 4, 2019, the Company and GACP entered into a waiver agreement, pursuant to which GACP agreed to waive breaches of certain covenants under the LSA occurring prior to, as of and after December 31, 2018 through April 8, 2019, including covenants related to quarterly minimum revenues, minimum liquidity amounts and a minimum asset coverage ratio. In connection with such waiver, the Company agreed to pay GACP fees of $0.8 million.

 

On April 15, 2019, the Company, GACP and Foris Ventures, LLC (Foris, an entity affiliated with director John Doerr of Kleiner Perkins Caufield & Byers, a current stockholder, and an owner of greater than five percent of the Company’s outstanding common stock) entered into a Loan Purchase Agreement, pursuant to which Foris agreed to purchase and assume from GACP, and GACP agreed to sell and assign to Foris, the outstanding loans under the LSA and all documents and assets related thereto. In connection with such purchase and assignment, the Company agreed to repay Foris $2.5 million of the purchase price paid by Foris to GACP (the Company LPA Obligation). The closing of the loan purchase and assignment occurred on April 16, 2019.

 

On August 14, 2019, the Company and Foris entered into an Amendment No 5 and Waiver to the LSA (the LSA Amendment and Waiver), pursuant to which (i) the maturity date of the loans under the LSA was extended from July 1, 2021 to July 1, 2022, (ii) the interest rate for the loans under the LSA was modified from the sum of (A) the greater of (x) the prime rate as reported in the Wall Street Journal or (y) 4.75% plus (B) 9% to the greater of (A) 12% or (B) the rate of interest payable with respect to any indebtedness of the Company, (iii) the amortization of the loans under the LSA was delayed until December 16, 2019, (iv) certain accrued and future interest and agency fee payments under the LSA were delayed until December 16, 2019, (v) certain covenants under the LSA, including related definitions, were amended to provide the Company with greater operational and financial flexibility, including, without limitation, to permit the incurrence of the indebtedness under the Naxyris Loan Facility (as described below) and the granting of liens with respect thereto, subject to the terms of an intercreditor agreement between Foris and Naxyris S.A. (Naxyris) governing the respective rights of the parties with respect to, among other things, the assets securing the Naxyris Loan Agreement and the LSA (the Intercreditor Agreement), (vi) certain outstanding unsecured promissory notes issued by the Company to Foris on April 8, 2019, June 11, 2019, July 10, 2019 and July 26, 2019 (as described below under “Foris Credit Agreements”), in an aggregate principal amount of $32.5 million, as well as the Company LPA Obligation, were added to the loans under the LSA, made subject to the LSA and secured by the security interest in the collateral granted to Foris under the LSA, and such promissory notes and contractual obligation were cancelled in connection therewith, and (vii) Foris agreed to waive certain existing defaults under the LSA. After giving effect to the LSA Amendment and Waiver, there is $71.0 million aggregate principal amount of loans outstanding under the LSA, including with respect to covenants related to quarterly minimum revenues, minimum liquidity amounts and a minimum asset coverage ratio. In connection with the entry into the LSA Amendment and Waiver, on August 14, 2019 the Company issued to Foris a warrant to purchase up to 1,438,829 shares of Common Stock at an exercise price of $2.87 per share, with an exercise term of two years from issuance. Pursuant to the terms of the warrant, Foris may not exercise the Foris Warrant to the extent that, after giving effect to such exercise, Foris, together with its affiliates, would beneficially own in excess of 19.99% of the number of shares of common stock outstanding after giving effect to such exercise, unless the Company has obtained stockholder approval to exceed such limit in accordance with Nasdaq rules and regulations, which the Company intends to seek at its 2019 annual meeting of stockholders.

 

Foris Credit Agreements

 

On April 8, 2019, the Company and Foris entered into an agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of $8.0 million, which the Company borrowed in full on April 8, 2019 and issued to Foris a promissory note in the principal amount of $8.0 million (the April Foris Note). The April Foris Note has a maturity date of October 14, 2019. In connection with the entry into the April Foris Credit Agreement and the issuance of the April Foris Note, which has no stated interest rate, the Company agreed to pay Foris a fee of $1.0 million, payable on or prior to the maturity date of the April Foris Note (the April Foris Note Fee); provided, that the April Foris Note Fee would be reduced to $0.5 million if the Company repaid the April Foris Note in full by July 15, 2019. The April Foris Note is subordinated in right of payment to the Tranche II Note held by Wolverine (see Note 5, “Debt” and above in this Note 16, “Subsequent Events”).

 

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On June 11, 2019, the Company and Foris entered into an agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of $8.5 million, which the Company borrowed in full on June 11, 2019 and issued to Foris a promissory note in the principal amount of $8.5 million (the June Foris Note). The June Foris Note (i) accrues interest at a rate of 12.5% per annum from and including June 11, 2019, which interest is payable on the maturity date or the earlier repayment or other satisfaction of the June Foris Note, and (ii) matures on August 28, 2019; provided, that if the May 2017 Cash Warrant held by DSM and the August 2017 DSM Cash Warrant (see Note 7, “Stockholders’ Deficit”) are exercised, then the maturity date of the June Foris Note will be the business day immediately following such exercise.

 

On July 10, 2019, the Company and Foris entered into a credit agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of $16.0 million (the July Foris Credit Agreement), of which the Company borrowed $8.0 million on July 10, 2019 and $8.0 million on July 26, 2019 and issued to Foris promissory notes, each in the principal amount of $8.0 million, on such dates (the July Foris Notes). The July Foris Notes (i) accrue interest at a rate of 12.5% per annum from and including the respective date of issuance, which interest is payable on the maturity date or the earlier repayment or other satisfaction of the applicable July Foris Note, and (ii) mature on December 31, 2019. In connection with the entry into the July Foris Credit Agreement, the Company and Foris amended the warrant issued to Foris on August 17, 2018 (see Note 7, “Stockholders’ Deficit”) to reduce the exercise price of such warrant from $7.52 per share to $2.87 per share.

 

The Company may at its option repay the amounts outstanding under the April Foris Note (including the April Foris Note Fee), the June Foris Note and the July Foris Notes before their respective maturity dates, in whole or in part, at a price equal to 100% of the amount being repaid plus, in the case of the June Foris Note and the July Foris Notes, accrued and unpaid interest on such amount to the date of repayment.

 

On August 14, 2019, the April Foris Note, the June Foris Note and the July Foris Notes were added to the loans under the LSA, made subject to the LSA and secured by the security interest in the collateral granted to Foris under the LSA, and such notes were cancelled in connection therewith. See above under “LSA Amendments, Assignment and Waivers” for additional information.

 

On August 28, 2019, the Company and Foris entered into a credit agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of $19.0 million (the August Foris Credit Agreement), which the Company borrowed in full on August 28, 2019 and issued to Foris a promissory note in the principal amount of $19.0 million (the August Foris Note). The August Foris Note (i) accrues interest at a rate of 12% per annum from and including August 28, 2019, which interest is payable quarterly in arrears on each March 31, June 30, September 30 and December 31, beginning December 31, 2019, and (ii) matures on January 1, 2023. The Company may at its option repay the amounts outstanding under the August Foris Note before the maturity date, in whole or in part, at a price equal to 100% of the amount being repaid plus accrued and unpaid interest on such amount to the date of repayment.

 

In connection with the entry into the August Foris Credit Agreement, on August 28, 2019 the Company issued to Foris a warrant to purchase up to 4,871,795 shares of Common Stock at an exercise price of $3.90 per share, with an exercise term of two years from issuance in a private placement pursuant to the exemption from registration under Section 4(a)(2) of the Securities Act of 1933, as amended (the Securities Act), and Regulation D promulgated under the Securities Act. The exercise price of the warrant is subject to standard adjustments but does not contain any anti-dilution protection, and the warrants only permit “cashless” or “net” exercise after the six-month anniversary of issuance of the applicable warrant, and only to the extent that there is not an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, Foris may not exercise the warrant to the extent that, after giving effect to such exercise, Foris, together with its affiliates, would beneficially own in excess of 19.99% of the number of shares of common stock outstanding after giving effect to such exercise, unless the Company has obtained stockholder approval to exceed such limit in accordance with Nasdaq rules and regulations, which the Company intends to seek at its 2019 annual meeting of stockholders.

 

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Private Placements

 

On April 16, 2019, the Company sold and issued to Foris 6,732,369 shares of common stock at a price of $2.87 per share, as well as a warrant to purchase up to 5,424,804 shares of common stock at an exercise price of $2.87 per share, with an exercise term of two years from issuance, in a private placement pursuant to the exemption from registration under Section 4(a)(2) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of $20.0 million (the Foris Investment). The Company used the proceeds from the Foris Investment to repay a portion of the 2015 Rule 144A Convertible Notes (see Note 5, “Debt”).

 

On April 26, 2019, the Company sold and issued (i) 2,832,440 shares of common stock at a price of $5.12 per share, as well as a warrant to purchase up to 3,983,230 shares of common stock at an exercise price of $5.12 per share, with an exercise term of two years from issuance, to Foris and (ii) an aggregate of 2,043,781 shares of common stock at a price of $4.02 per share, as well as warrants to purchase up to an aggregate of 1,635,025 shares of common stock at an exercise price of $5.02 per share, with an exercise term of two years from issuance, to certain other non-affiliated investors, in each case in private placements pursuant to the exemption from registration under Section 4(a)(2) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of $23.2 million. On August 28, 2019, in connection with the entry into the August Foris Credit Agreement (as described above under "Foris Credit Agreements"), the Company and Foris amended the warrant issued to Foris on April 26, 2019 to reduce the exercise price of such warrant from $5.12 per share to $3.90 per share.

 

On April 29, 2019, the Company sold and issued (i) 913,529 shares of common stock at a price of $4.76 per share, as well as a warrant to purchase up to 1,212,787 shares of common stock at an exercise price of $4.76 per share, with an exercise term of two years from issuance, to Vivo and (ii) an aggregate of 323,382 shares of common stock at a price of $4.02 per share, as well as warrants to purchase up to an aggregate of 258,704 shares of common stock at an exercise price of $5.02 per share, with an exercise term of two years from issuance, to certain other non-affiliated investors, in each case in private placements pursuant to the exemption from registration under Section 4(a)(2) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of $5.8 million.

 

On May 3, 2019, the Company sold and issued 1,243,781 shares of common stock at a price of $4.02 per share, as well as a warrant to purchase up to 995,024 shares of common stock at an exercise price of $5.02 per share, with an exercise term of two years from issuance, to a non-affiliated investor in a private placement pursuant to the exemption from registration under Section 4(a)(2) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of $5 million.

 

The exercise price of the warrants issued in the foregoing private placements is subject to standard adjustments but does not contain any anti-dilution protection, and the warrants only permit “cashless” or “net” exercise after the six-month anniversary of issuance of the applicable warrant, and only to the extent that there is not an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, in connection with the foregoing private placements, the Company agreed not to effect any exercise or conversion of any Company security, and the investors agreed not to exercise or convert any portion of any Company security, to the extent that after giving effect to such exercise or conversion, the applicable investor, together with its affiliates, would beneficially own in excess of 19.99% of the number of shares of common stock outstanding immediately after giving effect to such exercise or conversion, and the warrants contained a similar limitation. The Company intends to seek stockholder approval for Foris to exceed such limitation in accordance with Nasdaq rules and regulations at its 2019 annual meeting of stockholders.

 

DSM Agreements

 

On April 16, 2019, the Company assigned to DSM, and DSM assumed, all of the Company’s rights and obligations under the Value Sharing Agreement (see Note 10, “Revenue Recognition”), for aggregate consideration to the Company of $57.0 million, $29.1 million of which was paid to the Company in cash, with the remaining $27.9 million being used to pay certain existing obligations of the Company to DSM, including certain obligations under the Supply Agreement Amendment (see Note 10, “Revenue Recognition”). The Company used a majority of the cash proceeds to repay a portion of the 2015 Rule 144A Convertible Notes (see Note 5, “Debt”).

 

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In addition, on April 16, 2019 the Company and DSM entered into amendments to the Supply Agreement and the Performance Agreement (see Note 10, “Revenue Recognition”), as well as the Quota Purchase Agreement relating to the December 2017 sale of Amyris Brasil to DSM (see Note 13, “Divestiture” and Note 11, "Related Party Transactions"), pursuant to which (i) DSM agreed to reduce certain manufacturing costs and fees paid by the Company related to the production of farnesene under the Supply Agreement through 2021, as well as remove the priority of certain customers over the Company with respect to production capacity at the Brotas, Brazil facility, (ii) the Company agreed to provide DSM rights to conduct certain process and downstream recovery improvements under the Performance Agreement at facilities other than the Brotas, Brazil facility in exchange for DSM providing the Company with a license to such improvements and (iii) the Company released DSM from its obligation to provide manufacturing and support services under the Quota Purchase Agreement in connection with the Company’s planned new manufacturing facility, which is no longer planned to be located at the Brotas, Brazil location.

 

On September 17, 2019, the Company and DSM entered into a credit agreement (the “2019 DSM Credit Agreement”) to make available to the Company a secured credit facility in an aggregate principal amount of $8.0 million, to be issued in separate installments of $3.0 million, $3.0 million and $2.0 million, respectively, with each installment being subject to certain closing conditions, including the payment of certain existing obligations of the Company to DSM. On September 17, 2019, the Company borrowed the first installment of $3.0 million under the 2019 DSM Credit Agreement, all of which proceeds were used to pay certain existing obligations of the Company to DSM, and issued to DSM a promissory note in the principal amount of $3.0 million. On September 19, 2019, the Company borrowed the second installment of $3.0 million under the 2019 DSM Credit Agreement, all of which proceeds were used to pay certain existing obligations of the Company to DSM, and issued to DSM a promissory note in the principal amount of $3.0 million. On September 23, 2019, the Company borrowed the final installment of $2.0 million under the 2019 DSM Credit Agreement, $1.5 million of which proceeds were used to pay certain existing obligations of the Company to DSM, and issued to DSM a promissory note in the principal amount of $2.0 million. The promissory notes issued under the 2019 DSM Credit Agreement (i) mature on August 7, 2022, (ii) accrue interest at a rate of 12.5% per annum from and including the applicable date of issuance, which interest is payable quarterly in arrears on each January 1, April 1, July 1 and October 1, beginning January 1, 2020, and (iii) are secured by a first-priority lien on certain Company intellectual property licensed to DSM. The Company may at its option repay the amounts outstanding under the 2019 DSM Credit Agreement before the maturity date, in whole or in part, at a price equal to 100% of the amount being repaid plus accrued and unpaid interest on such amount to the date of repayment. In addition, the Company is required to repay the amounts outstanding under the 2019 DSM Credit Agreement (i) in an amount equal to the gross cash proceeds, if any, received by the Company upon the exercise by DSM of any of the common stock purchase warrants issued by the Company to DSM on May 11, 2017 or August 7, 2017 (see Note 7, “Stockholders’ Deficit”) and (ii) in full upon the request of DSM at any time following the receipt by the Company of at least $50.0 million of gross cash proceeds from one or more sales of equity securities of the Company on or prior to June 30, 2020.

 

Raizen Joint Venture Agreement

 

On May 10, 2019, the Company and Raizen Energia S.A. (Raizen) entered into an agreement relating to the formation and operation of a joint venture relating to the production, sale and commercialization of alternative sweetener products. In connection with the formation of the joint venture, among other things, (i) the joint venture will construct a manufacturing facility on land owned by Raizen and leased to the joint venture (the Sweetener Plant), (ii) the Company will grant to the joint venture an exclusive, royalty-free, worldwide, license to certain technology owned by the Company relevant to the joint venture’s business, and (iii) the Company and Raizen will enter into a shareholders agreement setting forth the rights and obligations of the parties with respect to, and the management of, the joint venture. The formation of the joint venture is subject to certain conditions, including certain regulatory approvals and the achievement of certain technological and economic milestones relating to the Company’s existing production of its alternative sweetener product. If such conditions are not satisfied by December 31, 2019, the joint venture will automatically terminate. In addition, notwithstanding the satisfaction of the closing conditions, Raizen may elect not to consummate the formation and operation of the joint venture, in which event, the Company will retain the right to construct and operate the Sweetener Plant.

 

Upon the closing of the joint venture, each party will make an initial capital contribution to the joint venture of 2,500,000 Brazilian Real (R$2,500,000) and the joint venture will be owned 50% by the Company and 50% by Raizen. Within 60 days of the formation, the parties will make an aggregate cash contribution to the joint venture of U.S.$9,000,000 to purchase certain fixed assets currently owned by the Company and located at the site of the Company’s former joint venture with Sao Martinho S.A. in Pradopolis, Brazil for U.S.$3,000,000. In addition, within six months of the formation, the Company will contribute to the joint venture its existing supply agreements related to its alternative sweetener product, subject to certain exceptions, in exchange for shares of dividend-bearing preferred stock in the joint venture, which will be entitled, for a period of 10 years commencing from the initial date of operation of the Sweetener Plant, to certain priority fixed cumulative dividends including, in the event that certain technological and economic milestones are met in any fiscal quarter, a percentage of the operating cash flow of the joint venture in such quarter.

 

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After the formation of the joint venture, the parties will not conduct activities similar or identical to the joint venture. In the event that certain technological and economic milestones are not met in any fiscal year beginning with the third fiscal year after formation of the joint venture and ending with the seventh fiscal year after formation of the joint venture, Raizen shall have the right to sell all of its shares in the joint venture to the Company at a price per share equal to the higher of the book value and the amount of Raizen’s investments in the joint venture, as adjusted for Raizen’s cost of capital.

 

2014 Rule 144A Convertible Notes Exchanges

 

On May 10, 2019, the Company exchanged $13.5 million aggregate principal amount of the 2014 Rule 144A Convertible Notes (see Note 5, “Debt”) held by certain non-affiliated investors, including accrued and unpaid interest thereon up to, but excluding, May 15, 2019, for an aggregate of 3,479,008 shares of common stock and warrants to purchase an aggregate of 1,391,603 shares of common stock at an exercise price of $5.02 per share, with an exercise term of two years from issuance, in a private exchange pursuant to the exemption from registration under Section 3(a)(9) of the Securities Act.

 

On May 14, 2019, the Company exchanged $5.0 million aggregate principal amount of the 2014 Rule 144A Convertible Notes held by Foris, including accrued and unpaid interest thereon up to, but excluding, May 15, 2019, for 1,122,460 shares of common stock and a warrant to purchase up to 352,638 shares of common stock at an exercise price of $4.56 per share, with an exercise term of two years from issuance, in a private exchange pursuant to the exemption from registration under Section 3(a)(9) of the Securities Act. On August 28, 2019, in connection with the entry into the August Foris Credit Agreement (as described above under "Foris Credit Agreements"), the Company and Foris amended the warrant issued to Foris on May 14, 2019 to reduce the exercise price of such warrant from $4.56 per share to $3.90 per share.

 

On May 15, 2019, the Company exchanged $10.0 million aggregate principal amount of the 2014 Rule 144A Convertible Notes held by Maxwell (Mauritius) Pte Ltd for 2,500,000 shares of common stock in a private exchange pursuant to the exemption from registration under Section 3(a)(9) of the Securities Act.

 

On May 15, 2019, the Company exchanged $9.7 million aggregate principal amount of the 2014 Rule 144A Convertible Notes held by Total for a new senior convertible note with an equal principal amount and with substantially identical terms, except that the new note had a maturity date of June 14, 2019, in a private exchange pursuant to the exemption from registration under Section 3(a)(9) of the Securities Act. Effective June 14, 2019, the Company and Total agreed to extend the maturity date of the new note from June 14, 2019 to July 18, 2019. Effective July 18, 2019, the Company and Total agreed to (i) further extend the maturity date of the new note from July 18, 2019 to August 28, 2019 and (ii) increase the interest rate on the new note to 10.5% per annum, beginning July 18, 2019. Effective August 28, 2019, the Company and Total agreed to (i) further extend the maturity date of the new note from August 28, 2019 to October 28, 2019 and (ii) increase the interest rate on the new note to 12% per annum, beginning August 28, 2019.

 

The exercise price of the warrants issued in the foregoing exchanges is subject to standard adjustments but does not contain any anti-dilution protection, and the warrants only permit “cashless” or “net” exercise after the six-month anniversary of the exercisability of the applicable warrant, and only to the extent that there is not an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, (i) the exercisability of the warrant issued to Foris is subject to stockholder approval in accordance with Nasdaq rules and regulations, which the Company intends to seek at its 2019 annual meeting of stockholders, and (ii) each other warrant provides that the Company may not effect any exercise of such warrant to the extent that, after giving effect to such exercise, the applicable holder, together with its affiliates, would beneficially own in excess of 4.99% of the number of shares of common stock outstanding after giving effect to such exercise.

 

6% Convertible Notes due 2021 Exchanges

 

On May 15, 2019 and June 24, 2019, the Company exchanged $53.3 million and $4.7 million principal amount, respectively, of the 6% Convertible Notes due 2021 (see Note 5, “Debt”), including accrued and unpaid interest thereon, representing all then-outstanding 6% Convertible Notes due 2021, for new senior convertible notes with an equal principal amount and warrants to purchase up to 2,000,000 and 181,818 shares of common stock, respectively, at an exercise price of $5.12 per share, with an exercise term of two years from issuance, in private exchanges pursuant to the exemption from registration under Section 3(a)(9) of the Securities Act. The new notes have substantially identical terms as the 6% Convertible Notes due 2021 being exchanged, except that (i) the holders agreed to waive, until July 22, 2019, certain covenants relating to the effectiveness of the registration statement covering the shares of common stock issuable upon conversion of, or otherwise pursuant to, the new notes and the filing by the Company of reports with the SEC and (ii) during the period from July 22, 2019 to July 29, 2019, inclusive, the holders have the right to require the Company to redeem the new notes, in whole or in part, at a price equal to 125% of the principal amount being redeemed. The exercise price of the warrants is subject to standard adjustments but does not contain any anti-dilution protection, and the warrants only permit “cashless” or “net” exercise after the six-month anniversary of issuance, and only to the extent that there is not an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, the holders may not exercise the warrants, and the Company may not effect any exercise of the warrants, to the extent that, after giving effect to such exercise, the applicable holder, together with its affiliates, would beneficially own in excess of 4.99% of the number of shares of common stock outstanding after giving effect to such exercise.

 

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On July 26, 2019, one of the holders of the senior convertibles notes issued in exchange for the 6% Convertible Notes due 2021, holding a senior convertible note in the principal amount of $4.7 million, exercised its right to require the Company to redeem such note in whole at a price equal to 125% of the principal amount being redeemed, plus accrued and unpaid interest on such note to the date of repayment. Redemption of such note was initially due on July 30, 2019 and subsequently extended to August 30, 2019. The Company redeemed such note in full on August 30, 2019.

 

On July 24, 2019, Company further exchanged $53.3 million principal amount of the previously-exchanged 6% Convertible Senior Notes due 2021 as well as the warrant to purchase up to 2,000,000 shares of common stock issued on May 15, 2019, for a new senior convertible note with a principal amount of $68.3 million (the Second Exchange Note) and a new warrant to purchase up to 2,000,000 shares of common stock at an exercise price of $2.87 per share, with an exercise term of two years from May 15, 2019 (the Second Exchange Warrant) in a private exchange pursuant to the exemption from registration under Section 3(a)(9) of the Securities Act. The Second Exchange Note and Second Exchange Warrant have substantially similar terms as the note and warrant, respectively, issued on May 15, 2019, except that (i) the principal amount of the Second Exchange Note would be $68.3 million, reflecting accrued and unpaid interest and late charges under the exchanged note and a 25% premium accruing as a result of the Company’s failure to make an installment payment on the exchanged note due July 1, 2019 in the amount of $6.4 million, provided that upon an event of default under the Second Exchange Note, the Company would not be required to redeem the Second Exchange Note in cash at a price greater than the intrinsic value of the shares of common stock underlying the Second Exchange Note, (ii) the Second Exchange Note bears interest at a rate of 18% per annum, (iii) the holder agreed to extend its waiver of certain covenant breaches relating to the failure by the Company to timely file periodic reports with the SEC from July 22, 2019 to September 16, 2019, (iv) the first installment date under the Second Exchange Note will occur on October 1, 2019, (v) the Company is required to (A) make principal payments on the Second Exchange Note in the amount of $3.2 million on each of August 2, 2019 and August 22, 2019, and (B) pay all remaining amounts then outstanding under the Second Exchange Note on September 16, 2019, and if the Company fails to make any such payment on the applicable payment date, the conversion price of the Second Exchange Note will be reset to the volume-weighted average price of the common stock on the trading day immediately following the Company’s filing of a Current Report on Form 8-K with respect to its failure to make the payment due on September 16, 2019, if such volume-weighted average price is lower than the conversion price of the Second Exchange Note then in effect, subject to a price floor and (vi) the Second Exchange Warrant has an exercise price of $2.87 per share.

 

On September 16, 2019, the Company failed to pay an aggregate of $63.6 million of outstanding principal and accrued interest on the Second Exchange Note when due. The failure resulted in an event of default under the Second Exchange Note and also triggered cross-defaults under other debt instruments of the Company which permitted the holders of such indebtedness to accelerate the amounts owing under such instruments. The Company subsequently received waivers from substantially all holders of such other debt instruments to waive the right to accelerate. As a result, the indebtedness with respect to which the Company has obtained such waivers continues to be classified as long-term on the Company’s balance sheet.  The indebtedness reflected by the Second Exchange Note continues to be classified as a current liability on the Company’s balance sheet. In addition, as a result of the payment default, the conversion price of the Second Exchange Note is subject to adjustment in accordance with the terms of the Second Exchange Note.

 

The Company does not currently have sufficient funds to repay the amounts outstanding under the Second Exchange Note. To date, negotiations with the holder of the Second Exchange Note have not been successful, and there can be no assurance that a favorable outcome for the Company will be reached. The Company has executed a term sheet with an existing investor for a term loan, the proceeds of which would be used to repay a portion of the Second Exchange Note. However, there can be no assurance that the Company will be able to obtain such financing on its expected timeline, or on acceptable terms, if at all. Even if the Company does obtain such financing, it will not have sufficient funds to repay the Second Exchange Note in full without obtaining additional financing, which the Company is attempting to source.

 

The consolidated financial statements do not include any adjustments that might result from the outcome of this uncertainty.

 

Exchange of August 2013 Financing Convertible Note

 

On July 8, 2019, the August 2013 Financing Convertible Note held by Wolverine (see Note 4, “Debt”) was exchanged for 1,767,632 shares of common stock and a warrant to purchase 1,080,000 shares of common stock in a private exchange pursuant to the exemption from registration under Section 3(a)(9) of the Securities Act. The exercise price of the warrant is subject to standard adjustments but does not contain any anti-dilution protection, and the warrant only permits “cashless” or “net” exercise after the six-month anniversary of issuance, and only to the extent that there is not an effective registration statement covering the resale of the shares of common stock underlying the warrant. In addition, Wolverine may not exercise the warrant to the extent that, after giving effect to such exercise, Wolverine, together with its affiliates, would beneficially own in excess of 4.99% of the number of shares of common stock outstanding after giving effect to such exercise.

 

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Nikko Loan Agreement

 

On July 29, 2019, the Company and Nikko Chemicals Co., Ltd. (Nikko) entered into a loan agreement (the Nikko Loan Agreement) to make available to the Company secured loans in an aggregate principal amount of $5.0 million, to be issued in separate installments of $3.0 million and $2.0 million, respectively, with each installment being subject to certain closing conditions, including the entry into certain commercial agreements and other arrangements relating to the Aprinnova JV (see Note 11, “Related Party Transactions”). On July 30, 2019, the Company borrowed the first installment of $3.0 million under the Nikko Loan Agreement and received net cash proceeds of $2.8 million, with the remaining $0.2 million being withheld by Nikko as prepayment of the interest payable on such loan through the maturity date. On August 8, 2019, the Company borrowed the remaining $2.0 million available under the Nikko Loan Agreement and received net cash proceeds of $1.9 million, with the remaining $0.1 million being withheld by Nikko as prepayment of the interest payable on such loan through the maturity date. The loans (i) mature on December 18, 2020, (ii) accrue interest at a rate of 5% per annum from and including the applicable loan date through the maturity date, which interest is required to be prepaid in full on the date of the applicable loan, and (iii) are secured by a first-priority lien on 12.8% of the Aprinnova JV interests owned by the Company.

 

Aprinnova Working Capital Loan

 

Effective July 31, 2019, the Company and Nikko agreed to extend the term of the Second Aprinnova Note (see Note 5, “Debt”) from August 1, 2019 to August 1, 2020.

 

Naxyris Loan and Security Agreement

 

On August 14, 2019, the Company, certain of the Company’s subsidiaries (the Subsidiary Guarantors) and, as lender, Naxyris, an existing stockholder of the Company and an investment vehicle owned by Naxos Capital Partners SCA Sicar, which is affiliated with NAXOS S.A.R.L. (Switzerland), for which director Carole Piwnica serves as director, entered into a Loan and Security Agreement (the Naxyris Loan Agreement) to make available to the Company a secured term loan facility in an aggregate principal amount of up to $10,435,000 (the Naxyris Loan Facility), which the Company borrowed in full on August 14, 2019.

 

Loans under the Naxyris Loan Facility have a maturity date of July 1, 2022 and accrue interest at a rate per annum equal to the greater of (i) 12% or (ii) the rate of interest payable with respect to any indebtedness of the Company plus 25 basis points, which interest will be payable monthly in arrears, provided that all interest accruing from and after August 14, 2019 through December 1, 2019 shall be due and payable on December 15, 2019.

 

The obligations of the Company under the Naxyris Loan Facility are (i) guaranteed by the Subsidiary Guarantors and (ii) secured by a perfected security interest in substantially all of the assets of the Company and the Subsidiary Guarantors (the Collateral), junior in payment priority to Foris Ventures subject to certain limitations and exceptions, as well as the terms of the Intercreditor Agreement (as defined above).

 

Mandatory prepayments of the outstanding amounts under the Naxyris Loan Facility will be required upon the occurrence of certain events, including asset sales, a change in control, and the incurrence of additional indebtedness, subject to certain exceptions and reinvestment rights. Outstanding amounts under the Naxyris Loan Facility must also be prepaid to the extent that the borrowing base exceeds the outstanding principal amount of the loans under the Naxyris Loan Facility. In addition, the Company may at its option prepay the outstanding principal amount of the loans under the Naxyris Loan Facility in full before the maturity date. Any prepayment of the loans under the Naxyris Loan Facility prior to the maturity date, whether pursuant to a mandatory or optional prepayment, is subject to a prepayment charge equal to one year’s interest at the then-current interest rate for the Naxyris Loan Facility. Upon the repayment of the loans under the Naxyris loan facility, whether on the maturity date or earlier pursuant to an optional or mandatory prepayment, the Company will pay Naxyris an end of term fee. In addition, (i) the Company will be required to pay a fee equal to 6% of any amount the Company fails to pay within three business days of its due date and (ii) any interest that is not paid when due will be added to principal and will bear compound interest at the applicable rate.

 

The affirmative and negative covenants in the Naxyris Loan Agreement relate to, among other items: (i) payment of taxes; (ii) financial reporting; (iii) maintenance of insurance; and (iv) limitations on indebtedness, liens, mergers, consolidations and acquisitions, transfers of assets, dividends and other distributions in respect of capital stock, investments, loans and advances, and corporate changes. The Naxyris Loan Agreement also contains financial covenants, including covenants related to minimum revenue, liquidity, and asset coverage.

 

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September 2019 Credit Agreements

 

On September 10, 2019, the Company entered into separate credit agreements (the “Investor Credit Agreements”) with each of Schottenfeld Opportunities Fund II, L.P., Phase Five Partners, LP and Koyote Trading, LLC (the “Investors”) to make available to the Company unsecured credit facilities in an aggregate principal amount of $12.5 million, which the Company borrowed in full on September 10, 2019 and issued to the Investors separate promissory notes in the aggregate principal amount of $12.5 million (the “Investor Notes”). Each Investor Note (i) accrues interest at a rate of 12% per annum from and including September 10, 2019, which interest is payable quarterly in arrears on each March 31, June 30, September 30 and December 31, beginning December 31, 2019, and (ii) matures on January 1, 2023. The Company may at its option repay the amounts outstanding under the Investor Notes before the maturity date, in whole or in part, at a price equal to 100% of the amount being repaid plus accrued and unpaid interest on such amount to the date of repayment.

 

In connection with the entry into the Investor Credit Agreements, on September 10, 2019, the Company issued to the Investors warrants to purchase up to an aggregate of 3,205,128 shares of Common Stock at an exercise price of $3.90 per share, with an exercise term of two years from issuance in a private placement pursuant to the exemption from registration under Section 4(a)(2) of the Securities Act and Regulation D promulgated under the Securities Act. The exercise price of the warrants is subject to standard adjustments but does not contain any anti-dilution protection, and the warrants only permit “cashless” or “net” exercise after the six-month anniversary of issuance of the applicable warrant, and only to the extent that there is not an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, no Investor may exercise its warrant to the extent that, after giving effect to such exercise, such Investor, together with its affiliates, would beneficially own in excess of 9.99% of the number of shares of common stock outstanding after giving effect to such exercise. In addition, the Company agreed to file a registration statement providing for the resale by the Investors of the shares of Common Stock underlying the warrants with the SEC within 60 days following the date of the issuance of the warrants and to use commercially reasonable efforts to (i) cause such registration statement to become effective within 120 days following the date of the issuance of the warrants and (ii) keep such registration statement effective until the Investors no longer beneficially own any such shares of Common Stock or such shares of Common Stock are eligible for resale under Rule 144 under the Securities Act without regard to volume limitations. If the Company fails to file the registration statement by the filing deadline or the registration statement is not declared effective by the effectiveness deadline, or the Company fails to maintain the effectiveness of the registration statement as required by the warrants, then the exercise price of the warrants will be reduced by 10%, and by an additional 5% if such failure continues for longer than 90 days, subject to an exercise price floor of $3.31 per share, provided that upon the cure by the Company of such failure, the exercise price of the warrants will revert to $3.90 per share.

 

In connection with the entry into the Investor Credit Agreements and the issuance of the warrants, on September 10, 2019, the Company and the Investors entered into a Standstill Agreement (the “Investor Standstill Agreement”), pursuant to which the Investors agreed that, until the earliest to occur of (i) the Investors no longer beneficially owning any shares underlying the warrants, (ii) the Company entering into a definitive agreement involving the direct or indirect acquisition of all or a majority of the Company’s equity securities or all or substantially all of the Company’s assets or (iii) a person or group, with the prior approval of the Company’s Board of Directors (the “Board”), commencing a tender offer for all or a majority of the Company's equity securities, neither the Investors nor any of their respective affiliates will (without the prior written consent of the Board), among other things, (i) acquire any loans, debt securities, equity securities, or assets of the Company or any of its subsidiaries, or rights or options with respect thereto, except that the Investors shall be permitted to (a) purchase the shares underlying the warrants pursuant to the exercise of the warrants and (b) acquire beneficial ownership of up to 6.99% of the Common Stock, or (ii) make any proposal, public announcement, solicitation or offer with respect to, or otherwise solicit, seek or offer to effect, or instigate, encourage, or assist any third party with respect to: (a) any business combination, merger, tender offer, exchange offer, or similar transaction involving the Company or any of its subsidiaries; (b) any restructuring, recapitalization, liquidation, or similar transaction involving the Company or any of its subsidiaries; (c) any acquisition of any of the Company’s loans, debt securities, equity securities or assets, or rights or options with respect thereto; or (d) any proposal to seek representation on the Board or otherwise seek to control or influence the management, Board, or policies of the Company, in each case subject to certain exceptions.

 

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Selected Quarterly Financial Data (Unaudited)

 

Summary of Quarterly Results of Operations

 

    2017   2018
(In thousands)   Three Months Ended
March 31, 2017
  Three Months Ended
June 30, 2017
  Three Months Ended
September 30, 2017
  Three Months Ended
December 31, 2017
  Three Months Ended
March 31, 2018
  Three Months Ended
June 30, 2018
  Three Months Ended
September 30, 2018
  Three Months Ended
December 31, 2018
    As Restated   As Restated   As Restated   As Restated   As Restated   As Restated   As Restated    
Revenue                                
Renewable products   $ 8,037     $ 9,892     $ 10,996     $ 13,445     $ 5,195     $ 6,633     $ 9,639     $ 12,131  
Licenses and royalties     255       1,236       4,483       42,729       7,955       (513 )     142       74  
Grants and collaborations     4,688       10,291       12,179       9,440       4,709       8,939       4,534       4,166  
Revenue   $ 12,980     $ 21,419     $ 27,658     $ 65,614     $ 17,859     $ 15,059     $ 14,315     $ 16,371  
Gross profit (loss) from product sales   $ (4,731 )   $ (6,305 )   $ (6,641 )   $ (2,260 )   $ (120 )   $ 99     $ 1,065     $ (4,144 )
Net income (loss)   $ (38,037 )   $ (23,621 )   $ (58,235 )   $ (36,089 )   $ (92,802 )   $ (14,381 )   $ (74,453 )   $ (48,599 )
Net loss attributable to Amyris, Inc. common stockholders:                                                                
Basic and diluted   $ (38,037 )   $ (39,784 )   $ (85,691 )   $ (33,191 )   $ (85,298 )   $ (13,411 )   $ (76,814 )   $ (46,738 )
Net loss per share attributable to common stockholders:                                                                
Basic and diluted   $ (1.97 )   $ (1.71 )   $ (2.34 )   $ (0.69 )   $ (1.67 )   $ (0.24 )   $ (1.26 )   $ (0.63 )
Weighted-average shares of common stock outstanding used in computing net loss per share of common stock:                                                                
Basic and diluted     19,268,060       23,200,460       36,643,901       47,895,238       51,200,922       54,932,411       60,966,071       74,265,076  

 

 

 

 90 

 

 

2017 AND 2018 QUARTERLY DATA — RESTATED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

 

 

In lieu of filing amended Quarterly Reports on Form 10-Q/A for the periods ended March 31, 2017, June 30, 2017 and September 30, 2017, and March 31, 2018, June 30, 2018 and September 30, 2018, quarterly financial data as restated is included in this Annual Report on Form 10-K in the tables that follow. Amounts are computed independently each quarter, therefore, the sum of the quarterly amounts may not equal the total amount for the respective year due to rounding.

 

2017 and 2018 Quarterly Data - Restated Condensed Consolidated Balance Sheets

 

(In thousands)   March 31,
 2017
  June 30,
 2017
  September 30,
 2017
  December 31,
 2017
  March 31,
 2018
  June 30,
 2018
  September 30,
 2018
    Restated   Restated   Restated   Restated   Restated   Restated   Restated
Assets                                                        
Current assets:                                                        
Cash and cash equivalents   $ 1,297     $ 5,078     $ 15,865     $ 57,059     $ 24,084     $ 14,050     $ 19,045  
Restricted cash     301       3,815       4,078       2,994       2,454       1,846       1,258  
Short-term investments     1,188       1,556       1,743                   130        
Accounts receivable, net     8,122       15,958       14,843       18,953       6,035       9,567       15,001  
Accounts receivable - related party, net     416       1,431       10,079       4,767       18,695       4,265       7,581  
Accounts receivable, unbilled - related party                       9,901       9,247       12,683       56  
Inventories     7,077       5,729       6,410       5,408       4,998       6,632       6,260  
Prepaid expenses and other current assets     5,652       7,440       9,244       4,919       7,340       4,687       5,541  
Total current assets     24,053       41,007       62,262       104,001       72,853       53,860       54,742  
Property, plant and equipment, net     53,045       49,303       50,130       13,892       13,262       15,300       16,622  
Accounts receivable, unbilled - related party, noncurrent                       7,940       7,940       9,747       9,767  
Restricted cash, noncurrent     958       958       958       959       959       959       959  
Recoverable taxes from Brazilian government entities                       1,445       1,226       1,057       1,053  
Other assets     17,388       18,204       21,998       12,559       12,287       14,329       14,396  
Total assets   $ 95,444     $ 109,472     $ 135,348     $ 140,796     $ 108,527     $ 95,252     $ 97,539  
Liabilities, Mezzanine Equity and Stockholders' Deficit                                                        
Current liabilities:                                                        
Accounts payable   $ 16,453     $ 13,575     $ 19,314     $ 15,515     $ 15,648     $ 19,206     $ 11,380  
Accrued and other current liabilities     32,211       29,873       28,883       29,202       27,702       22,746       37,711  
Contract liabilities     3,487       6,029       4,594       4,308       9,376       6,971       4,026  
Debt, current portion     15,290       7,954       6,070       36,924       35,950       60,105       62,056  
Related party debt, current portion     34,165       5,331       5,634       20,019       27,171       49,669       47,020  
Total current liabilities     101,606       62,762       64,495       105,968       115,847       158,697       162,193  
Long-term debt, net of current portion     132,425       107,906       106,699       60,220       60,462       43,763       43,788  
Related party debt, net of current portion     39,724       40,920       43,736       46,541       39,147       17,834       18,256  
Derivative liabilities     5,144       58,606       75,767       116,497       174,152       133,845       93,561  
Other noncurrent liabilities     23,462       20,767       18,271       23,658       22,436       22,073       21,293  
Total liabilities     302,361       290,961       308,968       352,884       412,044       376,212       339,091  
Commitments and contingencies                                                        
Mezzanine equity:                                                        
Contingently redeemable common stock     5,000       5,000       5,000       5,000       5,000       5,000       5,000  
Stockholders’ deficit:                                                        
Common stock - $0.0001 par value     2       3       4       5       5       5       6  
Additional paid-in capital    

1,000,200

     

1,050,670

      1,115,371       1,114,546       1,116,859       1,154,625       1,268,679  
Accumulated other comprehensive loss     (40,581 )     (42,003 )     (40,601 )     (42,156 )     (42,293 )     (43,120 )     (43,314 )
Accumulated deficit     (1,172,475 )     (1,196,096 )     (1,254,331 )     (1,290,420 )     (1,384,025 )     (1,398,407 )     (1,472,860 )
Total Amyris, Inc. stockholders’ deficit     (212,854 )     (200,256 )     (179,557 )     (218,025 )     (309,454 )     (286,897 )     (247,489 )
Noncontrolling interest     937       937       937       937       937       937       937  
Total stockholders' deficit     (211,917 )     (199,319 )     (178,620 )     (217,088 )     (308,517 )     (285,960 )     (246,552 )
Total liabilities, mezzanine equity and stockholders' deficit   $ 95,444     $ 109,472     $ 135,348     $ 140,796     $ 108,527     $ 95,252     $ 97,539  

 

 

 

 91 

 

 

2017 and 2018 Quarterly Data - Restated Condensed Consolidated Statements of Operations

 

2017

 

(In thousands, except shares and per share amounts)   Three Months Ended
March 31, 2017
  Three Months Ended
June 30, 2017
  Six Months Ended
June 30, 2017
  Three Months Ended
September 30, 2017
  Nine Months Ended
September 30, 2017
  Three Months Ended
December 31, 2017
  Year Ended
December 31, 2017
    Restated   Restated   Restated   Restated   Restated   Restated   Restated
                             
Renewable products   $ 8,037     $ 9,892     $ 17,929     $ 10,996     $ 28,925     $ 13,445     $ 42,370  
Licenses and royalties     255       1,236       1,491       4,483       5,974       42,729       48,703  
Grants and collaborations     4,688       10,291       14,979       12,179       27,158       9,440       36,598  
Total revenue     12,980       21,419       34,399       27,658       62,057       65,614       127,671  
Cost and operating expenses                                                        
Cost of products sold     12,768       16,197       28,965       17,637       46,602       15,705       62,307  
Research and development     14,778       14,178       28,956       15,185       44,141       13,421       57,562  
Sales, general and administrative     12,778       16,583       29,361       15,454       44,815       19,038       63,853  
Total cost and operating expenses     40,324       46,958       87,282       48,276       135,558       48,164       183,722  
Loss from operations     (27,344 )     (25,539 )     (52,883 )     (20,618 )     (73,501 )     17,450       (56,051 )
Other income (expense)                                                        
(Loss) gain on divestiture                                   5,732       5,732  
Interest expense     (12,850 )     (9,973 )     (22,823 )     (8,433 )     (31,256 )     (5,825 )     (37,081 )
(Loss) gain from change in fair value of derivative instruments     2,339       26,322       28,661       (29,827 )     (1,166 )     (47,686 )     (48,852 )
Loss upon extinguishment of debt     96       (14,000 )     (13,904 )     461       (13,443 )     1,546       (11,897 )
Other income (expense), net     (319 )     (121 )     (440 )     (136 )     (576 )     (380 )     (956 )
Total other expense, net     (10,734 )     2,228       (8,506 )     (37,935 )     (46,441 )     (46,613 )     (93,054 )
Loss before income taxes     (38,078 )     (23,311 )     (61,389 )     (58,553 )     (119,942 )     (29,163 )     (149,105 )
Provision for income taxes     41       (310 )     (269 )     318       49       (6,926 )     (6,877 )
Net loss attributable to Amyris, Inc.     (38,037 )     (23,621 )     (61,658 )     (58,235 )     (119,893 )     (36,089 )     (155,982 )
Less deemed dividend related to beneficial conversion feature on Series A preferred stock           (562 )     (562 )           (562 )           (562 )
Less deemed dividend related to beneficial conversion feature on Series B preferred stock                       (634 )     (634 )           (634 )
Less deemed dividend related to beneficial conversion feature on Series D preferred stock                       (5,757 )     (5,757 )           (5,757 )
Less deemed dividend upon settlement of make-whole provision on Series A preferred stock           (9,453 )     (9,453 )     (1,026 )     (10,479 )     (26 )     (10,505 )
Less deemed dividend upon settlement of make-whole provision on Series B preferred stock                       (21,992 )     (21,992 )     (640 )     (22,632 )
Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series A preferred stock           (18,362 )     (18,362 )     (1,784 )     (20,146 )     (1,432 )     (21,578 )
Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series B preferred stock                       (24,366 )     (24,366 )           (24,366 )
Add: losses allocated to participating securities           12,214       12,985       28,103       38,813       4,996       40,159  
Net loss attributable to Amyris, Inc. common stockholders   $ (38,037 )   $ (39,784 )   $ (77,050 )   $ (85,691 )   $ (165,016 )   $ (33,191 )   $ (201,857 )
                                                         
Loss per share attributable to common stockholders:                                                        
Basic and diluted   $ (1.97 )   $ (1.71 )   $ (3.63 )   $ (2.34 )   $ (6.12 )   $ (0.69 )   $ (6.26 )
Weighted-average shares of common stock outstanding used in computing loss per share of common stock:                                                        
Basic and diluted     19,268,060       23,200,460       21,248,306       36,643,901       26,982,385       47,895,238       32,253,570  

 

 

 92 

 

 

2018

 

Results of Operations

 

(In thousands, except shares and per share amounts)   Three Months Ended
March 31, 2018
  Three Months Ended
June 30, 2018
  Six Months Ended
June 30, 2018
  Three Months Ended
September 30, 2018
  Nine Months Ended
September 30, 2018
    Restated   Restated   Restated   Restated   Restated
                     
Renewable products   $ 5,195     $ 6,633     $ 11,828     $ 9,639     $ 21,467  
Licenses and royalties     7,955       (513 )     7,442       142       7,584  
Grants and collaborations     4,709       8,939       13,648       4,534       18,182  
Total revenue     17,859       15,059       32,918       14,315       47,233  
Cost and operating expenses                                        
Cost of products sold     5,315       6,534       11,849       8,574       20,423  
Research and development     17,825       15,669       33,494       16,445       49,939  
Sales, general and administrative     18,100       19,454       37,554       27,239       64,793  
Total cost and operating expenses     41,240       41,657       82,897       52,258       135,155  
Loss from operations     (23,381 )     (26,598 )     (49,979 )     (37,943 )     (87,922 )
Other income (expense)                                        
(Loss) gain on divestiture     (1,778 )           (1,778 )           (1,778 )
Interest expense     (9,978 )     (9,580 )     (19,558 )     (9,180 )     (28,738 )
(Loss) gain from change in fair value of derivative instruments     (58,357 )     21,990       (36,367 )     (24,797 )     (61,164 )
Loss upon extinguishment of debt           (26 )     (26 )           (26 )
Other income (expense), net     692       (168 )     524       (2,533 )     (2,009 )
Total other expense, net     (69,421 )     12,216       (57,205 )     (36,510 )     (93,715 )
Loss before income taxes     (92,802 )     (14,382 )     (107,184 )     (74,453 )     (181,637 )
Provision for income taxes                              
Net loss attributable to Amyris, Inc.     (92,802 )     (14,382 )     (107,184 )     (74,453 )     (181,637 )
Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series D preferred stock                       (6,852 )     (6,852 )
Add: losses allocated to participating securities     7,504       970       7,932       4,491       12,824  
Net loss attributable to Amyris, Inc. common stockholders   $ (85,298 )   $ (13,412 )   $ (99,252 )   $ (76,814 )   $ (175,665 )
                                         
Loss per share attributable to common stockholders:                                        
Basic and diluted   $ (1.67 )   $ (0.24 )   $ (1.87 )   $ (1.26 )   $ (3.15 )
Weighted-average shares of common stock outstanding used in computing loss per share of common stock:                                        
Basic and diluted     51,200,922       54,932,411       53,076,975       60,966,071       55,735,571  

 

Revenue

 

Three Months Ended September 30, 2018 Compared with Three Months Ended September 30, 2017. Total revenue decreased by 48%. Renewable products revenue decreased by 12% primarily due to the assignment of certain farnesene supply agreements to DSM and discontinuing the sales of low-margin products, partially offset by a $1.6 million increase in revenue from Biossance products. Licenses and royalties revenue decreased by 97% due to a license fee in 2017 from DSM for which there was no comparable revenue in 2018. Grants and collaborations revenue decreased by 63% mainly due to one-time revenue in 2017 upon the termination of the Braskem/Michelin agreement and lower grant revenue from DARPA.

 

Three Months Ended June 30, 2018 Compared with Three Months Ended June 30, 2017. Total revenue decreased by 30%. Renewable products revenue decreased by 33% to $6.6 million due to the assignment of certain farnesene supply agreements to DSM and discontinuing low margin product sales, partly offset by increases in sales of our Biossance and Neossance products. Licenses and royalties revenue decreased by 141% due to no royalty revenue in the June 30, 2018 period combined with early payment discounts taken in the 2018 period. Grants and collaborations revenue decreased by 13% primarily due to decreases from Biogen, Firmenich and DARPA totaling $2.5 million, partly offset by a $1.6 million increase from DSM.

 

Three Months Ended March 31, 2018 Compared with Three Months Ended March 31, 2017. Total revenue increased by 38% primarily due to a $7.7 million increase in license and royalty revenue related to royalty revenue from DSM. Renewable products revenue decreased by 37% as a result of the assignment of certain farnesene supply agreements to DSM and discontinuing low margin product sales, partially offset by increases in Biossance and Aprinnova revenue streams. Licenses and royalties revenue increased significantly due to royalty revenues from DSM, primarily due to the adoption of ASC 606, discussed elsewhere in this document. Grants and collaborations revenue was unchanged for the comparative period.

 

 93 

 

 

Costs and Operating Expenses

 

Three Months Ended September 30, 2018 Compared with Three Months Ended September 30, 2017. Costs of products sold decreased by 51%, primarily due to (i) the December 2017 sale of our Brotas production facility to DSM, which substantially reduced our fixed production costs, (ii) the assignment of certain farnesene supply agreements to DSM with a resulting 12% decrease in renewable products revenue, and (iii) our discontinuing manufacturing of low-margin products. Research and development expenses increased by 8% due to increases in headcount to support new product development and one-time costs related to product development. Sales, general and administrative expenses increase by 76%, primarily due to increases in headcount to support our growth and expansion, professional services costs, one-time costs associated with a contract termination, and a $6.8 million charge for legal expense in connection to the August warrants exercise transaction.

 

Three Months Ended June 30, 2018 Compared with Three Months Ended June 30, 2017. Costs of products sold decreased 62%, primarily due to (i) the December 2017 sale of our Brotas production facility to DSM, which substantially reduced our fixed production costs, (ii) the assignment of certain farnesene supply agreements to DSM with a resulting 33% decrease in renewable products revenue, and (iii) our discontinuing manufacturing of low-margin products. Research and development expenses increased by 11% due to increases in headcount to support new product development and one-time costs related to product development. Sales, general and administrative expenses increased by 17% primarily due to increases in headcount to support our growth and expansion, and professional services costs, partially offset by a $0.7 million credit for services provided to a related party.

 

Three Months Ended March 31, 2018 Compared with Three Months Ended March 31, 2017. Costs of products sold decreased by 58% to $7.4 million primarily due to the December 2017 sale of our Brotas 1 production facility to DSM, which substantially reduced our fixed production costs, and due to the assignment of certain farnesene supply agreements to DSM and our discontinuing manufacturing of low-margin products. Research and development expenses increased by 21% to $17.8 million due to increases in headcount to support new product development and one-time costs related by product development. Sales, general and administrative expenses increased by 42% as a result of increases in headcount to support our growth, professional services costs, and costs related to the Amyris Brasil Ltda. transaction.

 

Other Expense, Net

 

Three Months Ended September 30, 2018 Compared with Three Months Ended September 30, 2017. Total other expense, net was $36.5 million for the three months ended September 30, 2018, compared to total other expense, net of $37.9 million for the same period in 2017. The $1.4 million decrease was primarily due to a $5.0 million decrease in the loss from change in fair value of derivative instruments, partially offset by a $2.4 million increase in other expense, which was primarily comprised of issuance costs incurred in connection with our August 2018 secondary offering in which existing shareholders sold approximately 7.7 million shares, and an additional $0.7 million increase related to an increase in interest expense.

 

Three Months Ended June 30, 2018 Compared with Three Months Ended June 30, 2017. The $8.2 million increase in total other income, net, was primarily due to a decrease in expense of $12.2 million associated with certain May 2017 warrant exercise, partially offset by the decrease in gain in fair value of derivative instruments.

 

Three Months Ended March 31, 2018 Compared with Three Months Ended March 31, 2017. The $59.3 million change in total other expense, net, was primarily due to a $58.3 million loss on the change in fair value of derivative instruments, partially offset by a $2.2 million decrease in interest expense. The loss from change in fair value of derivative instruments for the three months ended March 31, 2018 was the result of a significant increase in derivative instruments issued subsequent to March 31, 2017, and a 78% increase to our stock price during the first quarter of 2018. The $1.8 million loss on divestiture was the result of a working capital adjustment to the sale price of the Brotas 1 facility, which we sold to a related party in December 2017.

 

 94 

 

 

Q1 2017 Operating Highlights

 

Condensed Consolidated Balance Sheet

 

    March 31, 2017
(In thousands)   As Previously Reported   Adjustments   Ref.   As Restated
                 
Assets                            
Current assets:                            
Cash and cash equivalents   $ 1,297     $         $ 1,297  
Restricted cash     301                 301  
Short-term investments     1,188                 1,188  
Accounts receivable, net     8,122                 8,122  
Accounts receivable - related party, net     416                 416  
Inventories     7,077                 7,077  
Prepaid expenses and other current assets     5,652                 5,652  
Total current assets     24,053                 24,053  
Property, plant and equipment, net     53,045                 53,045  
Restricted cash, noncurrent     958                 958  
Other assets     17,388                 17,388  
Total assets   $ 95,444     $         $ 95,444  
Liabilities, Mezzanine Equity and Stockholders' Deficit                            
Current liabilities:                            
Accounts payable   $ 16,453     $         $ 16,453  
Accrued and other current liabilities     32,211                 32,211  
Contract liabilities     3,487                 3,487  
Debt, current portion     15,290                 15,290  
Related party debt, current portion     34,165                 34,165  
Total current liabilities     101,606                 101,606  
Long-term debt, net of current portion     131,759       666     j     132,425  
Related party debt, net of current portion     39,724                 39,724  
Derivative liabilities     5,144                 5,144  
Other noncurrent liabilities     23,462                 23,462  
Total liabilities     301,695       666           302,361  
Commitments and contingencies                            
Mezzanine equity:                            
Contingently redeemable common stock     5,000                 5,000  
Stockholders’ deficit:                            
Common stock - $0.0001 par value(1)     2                 2  
Additional paid-in capital     1,000,200                 1,000,200  
Accumulated other comprehensive loss     (40,581 )               (40,581 )
Accumulated deficit     (1,171,809 )     (666 )   p     (1,172,475 )
Total Amyris, Inc. stockholders’ deficit     (212,188 )     (666 )         (212,854 )
Noncontrolling interest     937                 937  
Total stockholders' deficit     (211,251 )     (666 )         (211,917 )
Total liabilities, mezzanine equity and stockholders' deficit   $ 95,444     $         $ 95,444  

 

(1)  Reflects the 15:1 reverse stock split effected by the Company on June 5, 2017.

 

Restatement adjustments:

j. Correction to amortization of debt discounts.

p. Impact to net loss of correction to amortization of debt discounts.

 

 95 

 

 

Condensed Consolidated Statements of Operations

 

   Three Months Ended
March 31, 2017
(In thousands, except shares and per share amounts)  As Previously Reported  Reclassifications(1)  Corrections  Ref  As Restated
                
Revenue                       
Renewable products  $8,292   $(255)  $      $8,037 
Licenses and royalties       255           255 
Grants and collaborations   4,688               4,688 
Total revenue   12,980               12,980 
Cost and operating expenses                       
Cost of products sold   12,768               12,768 
Research and development   14,778               14,778 
Sales, general and administrative   12,778               12,778 
Total cost and operating expenses   40,324               40,324 
Loss from operations   (27,344)              (27,344)
Other income (expense)                       
Interest expense   (12,184)       (666)  ah   (12,850)
(Loss) gain from change in fair value of derivative instruments   2,339               2,339 
Loss upon extinguishment of debt   96               96 
Other income (expense), net   (319)              (319)
Total other expense, net   (10,068)       (666)      (10,734)
Loss before income taxes   (37,412)       (666)      (38,078)
Provision for income taxes   41               41 
Net loss attributable to Amyris, Inc.   (37,371)       (666)      (38,037)
Add: losses allocated to participating securities                   
Net loss attributable to Amyris, Inc. common stockholders  $(37,371)  $   $(666)     $(38,037)
                        
Loss per share attributable to common stockholders:                       
Basic and diluted  $(1.93)               $(1.97)
Weighted-average shares of common stock outstanding used in computing loss per share of common stock:                       
Basic and diluted   19,335,948             av   19,268,060 

 

 

(1) Reclassification of revenue by type to conform to the Company's current presentation.

Restatement adjustments:

ah. Correction to amortization of debt discounts.

av. Correction to weighted-average shares outstanding.

 

 96 

 

 

Condensed Consolidated Statements of Cash Flows

 

    Three Months Ended March 31, 2017
(In thousands)   As Previously Reported   Corrections(1)   As Restated
             
Operating activities                        
Net loss   $ (37,371 )     (666 )   $ (38,037 )
Adjustments to reconcile net loss to net cash used in operating activities:                        
Depreciation and amortization     2,715             2,715  
(Gain) loss on disposal of property, plant and equipment     (55 )           (55 )
Stock-based compensation     1,646             1,646  
Amortization of debt discount     4,473       666       5,139  
(Gain) loss upon extinguishment of debt     (96 )           (96 )
(Gain) loss from change in fair value of derivative liabilities     (2,339 )           (2,339 )
(Gain) loss on foreign currency exchange rates     (295 )           (295 )
Changes in assets and liabilities:                        
Accounts receivable     5,388             5,388  
Inventories     (867 )           (867 )
Prepaid expenses and other assets     (713 )           (713 )
Accounts payable     450             450  
Accrued and other liabilities     3,515             3,515  
Contract liabilities     (1,844 )           (1,844 )
Net cash used in operating activities     (25,393 )           (25,393 )
Investing activities                        
Change in short-term investments     329             329  
Purchases of property, plant and equipment     (457 )           (457 )
Net cash (used in) provided by investing activities     (128 )           (128 )
Financing activities                        
Payment of minimum employee taxes withheld upon net share settlement of restricted stock units     (22 )           (22 )
Principal payments on capital leases     (627 )           (627 )
Proceeds from issuance of debt, net of issuance costs     1,500             1,500  
Principal payments on debt     (5,124 )           (5,124 )
Net cash provided by financing activities     (4,273 )           (4,273 )
Effect of exchange rate changes on cash, cash equivalents and restricted cash     (83 )           (83 )
Net (decrease) increase in cash, cash equivalents and restricted cash     (29,877 )           (29,877 )
Cash, cash equivalents and restricted cash at beginning of year     32,433             32,433  
Cash, cash equivalents and restricted cash at end of year   $ 2,556     $     $ 2,556  
                         
Reconciliation of cash, cash equivalents and restricted cash to the consolidated balance sheets                        
Cash and cash equivalents   $ 1,297             $ 1,297  
Restricted cash, current     301               301  
Restricted cash, noncurrent     958               958  
Total cash, cash equivalents and restricted cash   $ 2,556             $ 2,556  

 

(1) To reflect the impact of restatement corrections on the statement of cash flows.

 

 97 

 

 

Q2 2017

 

Condensed Consolidated Balance Sheet

 

    June 30, 2017
(In thousands)   As Previously Reported   Corrections   Ref.   As Restated
                 
Assets                            
Current assets:                            
Cash and cash equivalents   $ 5,078               $ 5,078  
Restricted cash     3,815                 3,815  
Short-term investments     1,556                 1,556  
Accounts receivable, net     15,958                 15,958  
Accounts receivable - related party, net     1,431                 1,431  
Inventories     5,729                 5,729  
Prepaid expenses and other current assets     7,440                 7,440  
Total current assets     41,007                 41,007  
Property, plant and equipment, net     49,303                 49,303  
Restricted cash, noncurrent     958                 958  
Other assets     21,437       (3,233 )   d     18,204  
Total assets   $ 112,705     $ (3,233 )       $ 109,472  
Liabilities, Mezzanine Equity and Stockholders' Deficit                            
Current liabilities:                            
Accounts payable   $ 14,657     $ (1,082 )   e   $ 13,575  
Accrued and other current liabilities     29,873                 29,873  
Contract liabilities     5,001       1,028     g     6,029  
Debt, current portion     7,954                 7,954  
Related party debt, current portion     5,331                 5,331  
Total current liabilities     62,816       (54 )         62,762  
Long-term debt, net of current portion     111,112       (3,206 )   j     107,906  
Related party debt, net of current portion     40,920                 40,920  
Derivative liabilities     58,606                 58,606  
Other noncurrent liabilities     20,767                 20,767  
Total liabilities     294,221       (3,260 )         290,961  
Commitments and contingencies                            
Mezzanine equity:                            
Contingently redeemable common stock     5,000                 5,000  
Convertible preferred stock     12,830      

(12,830

)   m      
Stockholders’ deficit:                            
Common stock - $0.0001 par value     3                 3  
Additional paid-in capital    

1,012,906

      37,764     m / n    

1,050,670

 
Accumulated other comprehensive loss     (42,003 )               (42,003 )
Accumulated deficit     (1,171,189 )     (24,907 )   p     (1,196,096 )
Total Amyris, Inc. stockholders’ deficit     (200,283 )     12,857           (187,426 )
Noncontrolling interest     937                 937  
Total stockholders' deficit     (199,346 )     12,857           (186,489 )
Total liabilities, mezzanine equity and stockholders' deficit   $ 112,705     $ (3,233 )       $ 109,472  

 

Restatement adjustments:

d. Revision to accounting for a license sale to a customer for which the customer paid the Company in equity.

e. Correction to uninvoiced receipts liability.

g. Revision to accounting for a license sale to a customer for which the customer paid the Company in equity, and shift in timing of royalty revenue recognition.

j. Correction to debt discount in connection with Fidelity 2015 144A Note.

m. Correction to temporary equity classification of the May 2017 Preferred Stock Series B.

n. Correction to the settlement of a make-whole provision, and loss on extinguishment of related party debt in connection with May 2017 equity offering and correction to debt discount related to 2015 144A Notes.

p. Cumulative impact of restatement corrections on accumulated deficit.

 

 98 

 

 

Condensed Consolidated Statements of Operations

 

  Three Months Ended
June 30, 2017
  Six Months Ended
June 30, 2017
(In thousands, except shares and per share amounts)  As Previously Reported  Reclassifications(1)  Corrections  Ref  As Restated  As Previously Reported  Reclassifications(1)  Corrections  Ref  As Restated
                               
Revenue                                              
Renewable products  $12,729   $(2,837)  $      $9,892   $21,021   $(3,092)  $      $17,929 
Licenses and royalties       5,497    (4,261)  ab   1,236        5,752    (4,261)  ab   1,491 
Grants and collaborations   12,950    (2,660)   1      10,291    17,638    (2,660)   1      14,979 
Total revenue   25,679        (4,260)      21,419    38,659        (4,260)      34,399 
Cost and operating expenses                                              
Cost of products sold   17,279        (1,082)  ad   16,197    30,047        (1,082)  ad   28,965 
Research and development   14,249    (72)   1      14,178    29,027    (72)   1      28,956 
Sales, general and administrative   15,949    72    562   af   16,583    28,727    72    562   af   29,361 
Total cost and operating expenses   47,477        (519)      46,958    87,801        (519)      87,282 
Loss from operations   (21,798)       (3,741)      (25,539)   (49,142)       (3,741)      (52,883)
Other income (expense)                                              
(Loss) gain on divestiture                                      
Interest expense   (9,303)       (670)  ah   (9,973)   (21,487)       (1,336)  ah   (22,823)
(Loss) gain from change in fair value of derivative instruments   35,775        (9,453)  ai   26,322    38,114        (9,453)  ai   28,661 
Loss upon extinguishment of debt   (3,624)       (10,376)  ak   (14,000)   (3,528)       (10,376)  ak   (13,904)
Other income (expense), net   (120)       (1)     (121)   (439)       (1)     (440)
Total other expense, net   22,728        (20,500)      2,228    12,660        (21,166)      (8,506)
Loss before income taxes   930        (24,241)      (23,311)   (36,482)       (24,907)      (61,389)
Provision for income taxes   (310)              (310)   (269)              (269)
Net loss attributable to Amyris, Inc.   620        (24,241)      (23,621)   (36,751)       (24,907)      (61,658)
Less deemed dividend on capital distribution to related parties   (8,648)       8,648   an       (8,648)       8,648   an    
Less deemed dividend related to beneficial conversion feature on Series A preferred stock   (562)              (562)   (562)              (562)
Less deemed dividend upon settlement of make-whole provision on Series A preferred stock           (9,453)  ap   (9,453)           (9,453)  ap   (9,453)
Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series A preferred stock           (18,362)  ar   (18,362)           (18,362)  ar   (18,362)
Less cumulative dividends on Series A and Series B preferred stock   (1,675)        1,675   aw       (1,675)       1,675   aw    
Add: losses allocated to participating securities           12,214   au   12,214            12,985   au   12,985 
Net loss attributable to Amyris, Inc. common stockholders  $(10,265)      $(29,519)     $(39,784)  $(47,636)      $(29,414)     $(77,050)
                                               
Loss per share attributable to common stockholders:                                              
Basic and diluted  $(0.44)               $(1.71)  $(2.24)               $(3.63)
Weighted-average shares of common stock outstanding used in computing loss per share of common stock:                                              
Basic and diluted   23,155,874             av   23,200,460    21,226,013             av   21,248,306 

 

(1) Reclassification of revenue and operating expense by type to conform to the Company's current presentation.

 

Restatement adjustments:

ab. Adjustment for revenue reversal related to non-cash consideration and timing of revenue recognition between quarters.

ad. Correction in connection with a sales return.

af. Correction to accounting for expenses incurred in connection with May 2017 Offering.

ah. Correction to amortization of debt discounts.

ai. Correction to accounting for make-whole liability in connection with May 2017 Offering.

ak. Correction to accounting for debt exchanges.

an. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings

ap. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings.

ar. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings

au. Correction in the computation of net loss per share to reflect participating securities.

av. Correction to weighted-average shares outstanding.

aw. Correction in the computation of net loss per share related to make-whole deemed dividends.

 

 99 

 

 

Condensed Consolidated Statements of Cash Flows

 

   Six Months Ended June 30, 2017
(In thousands)  As Previously Reported  Corrections (1)  As Restated
          
Operating activities               
Net loss  $(36,751)  $(24,907)  $(61,658)
Adjustments to reconcile net loss to net cash used in operating activities:               
Depreciation and amortization   5,550        5,550 
(Gain) loss on disposal of property, plant and equipment   (161)       (161)
Stock-based compensation   2,684        2,684 
Amortization of debt discount   7,637    4,042    11,679 
(Gain) loss upon extinguishment of debt   3,528    10,376    13,904 
Receipt of equity in connection with collaboration arrangements revenue   (2,660)   2,660     
(Gain) loss from change in fair value of derivative liabilities   (38,115)   9,453    (28,662)
(Gain) loss on foreign currency exchange rates   63        63 
Changes in assets and liabilities:               
Accounts receivable   (3,509)       (3,509)
Inventories   409        409 
Prepaid expenses and other assets   (4,220)   3,233    (987)
Accounts payable   (1,739)   657    (1,082)
Accrued and other liabilities   7,105    (7,105)     
Contract liabilities       1,028    1,028 
Net cash used in operating activities   (60,179)   (563)   (60,742)
Investing activities               
Change in short-term investments   (85)       (85)
Purchases of property, plant and equipment   (264)       (264)
Net cash (used in) provided by investing activities   (349)       (349)
Financing activities               
Proceeds from issuance of convertible preferred stock   50,661    562    51,223 
Proceeds from exercises of common stock options   69        69 
Payment of minimum employee taxes withheld upon net share settlement of restricted stock units   (110)       (110)
Principal payments on capital leases   (764)       (764)
Proceeds from issuance of debt, net of issuance costs   12,455        12,455 
Principal payments on debt   (24,372)       (24,372)
Net cash provided by financing activities   37,939    562    38,501 
Effect of exchange rate changes on cash, cash equivalents and restricted cash   7        7 
Net (decrease) increase in cash, cash equivalents and restricted cash   (22,582)      (22,582)
Cash, cash equivalents and restricted cash at beginning of year   32,433        32,433 
Cash, cash equivalents and restricted cash at end of year  $9,851   $  $9,851 
                
Reconciliation of cash, cash equivalents and restricted cash to the consolidated balance sheets               
Cash and cash equivalents  $5,078        $5,078 
Restricted cash, current   3,815         3,815 
Restricted cash, noncurrent   958         958 
Total cash, cash equivalents and restricted cash  $9,851        $9,851 

 

(1) To reflect the impact of restatement corrections on the statement of cash flows.

 

 

 100 

 

 

Q3 2017 Quarterly Data Restatement Adjustments

 

Condensed Consolidated Balance Sheet

 

    September 30, 2017
(In thousands)   As Previously Reported   Corrections   Ref.   As Restated
                 
Assets                            
Current assets:                            
Cash and cash equivalents   $ 15,865     $         $ 15,865  
Restricted cash     4,078                 4,078  
Short-term investments     1,743                 1,743  
Accounts receivable, net     24,922       (10,079 )   a     14,843  
Accounts receivable - related party, net           10,079     a     10,079  
Inventories     6,410                 6,410  
Prepaid expenses and other current assets     9,244                 9,244  
Total current assets     62,262                 62,262  
Property, plant and equipment, net     50,130                 50,130  
Restricted cash, noncurrent     958                 958  
Other assets     25,231       (3,233 )   d     21,998  
Total assets   $ 138,581     $ (3,233 )       $ 135,348  
Liabilities, Mezzanine Equity and Stockholders' Deficit                            
Current liabilities:                            
Accounts payable   $ 20,396     $ (1,082 )   e   $ 19,314  
Accrued and other current liabilities     28,883                 28,883  
Contract liabilities     7,027       (2,433 )   g     4,594  
Debt, current portion     6,070                 6,070  
Related party debt, current portion     5,634                 5,634  
Total current liabilities     68,010       (3,515 )         64,495  
Long-term debt, net of current portion     109,205       (2,506 )   j     106,699  
Related party debt, net of current portion     43,736                 43,736  
Derivative liabilities     89,770       (14,003 )   l     75,767  
Other noncurrent liabilities     18,271                   18,271  
Total liabilities     328,992       (20,024 )         308,968  
Commitments and contingencies                            
Mezzanine equity:                            
Contingently redeemable common stock     5,000                 5,000  
Stockholders’ deficit:                            
Common stock - $0.0001 par value     4                 4  
Additional paid-in capital     1,049,299       66,072     n     1,115,371  
Accumulated other comprehensive loss     (40,601 )               (40,601 )
Accumulated deficit     (1,205,050 )     (49,281 )   p     (1,254,331 )
Total Amyris, Inc. stockholders’ deficit     (196,348 )     16,791           (179,557 )
Noncontrolling interest     937                 937  
Total stockholders' deficit     (195,411 )     16,791           (178,620 )
Total liabilities, mezzanine equity and stockholders' deficit   $ 138,581     $ (3,233 )       $ 135,348  

 

Restatement adjustments:

a. Reclassification of related party accounts receivable to a separate line on the balance sheet.

d. Reversal of the fair value of non-cash consideration received in connection with a revenue arrangement.

e. Correction in connection with a sales return.

g. Revision to accounting for a license sale to a customer for which the customer paid the Company in equity, and shift in timing of royalty revenue recognition.

j. Correction to debt discount in connection with Fidelity 2015 144A Note.

l. Correction to extinguishment accounting for a make-whole equity instrument, and loss on extinguishment of related party debt in connection with May 2017 equity offering.

n. Correction to the settlement of a make-whole equity instrument, and loss on extinguishment of related party debt in connection with May 2017 equity offering.

p. Cumulative impact of restatement corrections on accumulated deficit.

 

 101 

 

 

Condensed Consolidated Statements of Operations

 

  Three Months Ended
September 30, 2017
  Nine Months Ended
September 30, 2017
(In thousands, except shares and per share amounts)  As Previously Reported  Reclassifications(1)  Corrections  Ref  As Restated  As Previously Reported  Reclassifications(1)  Corrections  Ref  As Restated
                               
                               
Renewable products  $11,315   $(319)  $      $10,996   $32,336   $(3,411)  $      $28,925 
Licenses and royalties       1,022    3,461   ab   4,483        6,774    (800)  ab   5,974 
Grants and collaborations   12,882    (703)          12,179    30,520    (3,363)   1      27,158 
Total revenue   24,197        3,461       27,658    62,856        (799)      62,057 
Cost and operating expenses                                              
Cost of products sold   17,637               17,637    47,684        (1,082)  ad   46,602 
Research and development   15,185               15,185    44,212    (72)   1      44,141 
Sales, general and administrative   15,454               15,454    44,181    72    562   af   44,815 
Total cost and operating expenses   48,276               48,276    136,077        (519)      135,558 
Loss from operations   (24,079)       3,461       (20,618)   (73,221)       (280)      (73,501)
Other income (expense)                                              
Interest expense   (7,733)       (700)  ah   (8,433)   (29,220)       (2,036)  ah   (31,256)
(Loss) gain from change in fair value of derivative instruments   (2,692)       (27,135)  ai   (29,827)   35,422        (36,588)  ai   (1,166)
Loss upon extinguishment of debt   461               461    (3,067)       (10,376)  ak   (13,443)
Other income (expense), net   (136)              (136)   (575)       (1)     (576)
Total other expense, net   (10,100)       (27,835)      (37,935)   2,560        (49,001)      (46,441)
Loss before income taxes   (34,179)       (24,374)      (58,553)   (70,661)       (49,281)      (119,942)
Provision for income taxes   318               318    49               49 
Net loss attributable to Amyris, Inc.   (33,861)       (24,374)      (58,235)   (70,612)       (49,281)      (119,893)
Less deemed dividend on capital distribution to related parties                      (8,648)       8,648   an    
Less deemed dividend related to beneficial conversion feature on Series A preferred stock                      (562)              (562)
Less deemed dividend related to beneficial conversion feature on Series B preferred stock   (634)              (634)   (634)              (634)
Less deemed dividend related to beneficial conversion feature on Series D preferred stock   (5,757)              (5,757)   (5,757)              (5,757)
Less deemed dividend upon settlement of make-whole provision on Series A preferred stock           (1,026)  ap   (1,026)           (10,479)  ap   (10,479)
Less deemed dividend upon settlement of make-whole provision on Series B preferred stock           (21,992)  aq   (21,992)           (21,992)  aq   (21,992)
Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series A preferred stock           (1,784)  ar   (1,784)           (20,146)  ar   (20,146)
Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series B preferred stock           (24,366)  as   (24,366)           (24,366)  as   (24,366)
Less cumulative dividends on Series A and Series B preferred stock   (2,567)        2,567   aw       (4,242)       4,242   aw    
Add: losses allocated to participating securities           28,103   au   28,103            38,813   au   38,813 
Net loss attributable to Amyris, Inc. common stockholders  $(42,819)      $(42,872)     $(85,691)  $(90,455)      $(74,561)     $(165,016)
                                               
Loss per share attributable to common stockholders:                                              
Basic and diluted  $(1.14)               $(2.34)  $(3.32)               $(6.12)
Weighted-average shares of common stock outstanding used in computing loss per share of common stock:                                              
Basic and diluted   37,529,694             av   36,643,901    27,280,894             av   26,982,385 

 

(1) Reclassification of revenue by type to conform to the Company's current presentation.

 

Restatement adjustments:

ab. Revision to accounting for license revenue for non-cash consideration and change in timing of recognition from a customer.

ad. Correction in connection with a sales return.

af. Correction to accounting for expenses incurred in connection with May 2017 Offering.

ah. Correction to amortization of debt discounts.

ai. Correction to accounting for make-whole liability in connection with May 2017 Offering.

ak. Correction to accounting for certain debt exchanges.

an. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings

ap. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings

aq. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings

ar. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings

as. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings

au. Correction in the computation of net loss per share to reflect participating securities.

av. Correction to weighted-average shares outstanding.

aw. Correction in the computation of net loss per share related to make-whole deemed dividends.

 

 102 

 

 

Condensed Consolidated Statements of Cash Flows

 

   Nine Months Ended September 30, 2017
(In thousands)  As Previously Reported  Corrections (1)  As Restated
          
Operating activities               
Net loss  $(70,612)   (49,281)  $(119,893)
Adjustments to reconcile net loss to net cash used in operating activities:               
Depreciation and amortization   8,124        8,124 
(Gain) loss on disposal of property, plant and equipment   37        37 
Stock-based compensation   3,942        3,942 
Amortization of debt discount   10,108    4,327    14,435 
(Gain) loss upon extinguishment of debt   3,067    10,376    13,443 
Receipt of equity in connection with collaboration arrangements revenue   (2,660)   2,660     
(Gain) loss from change in fair value of derivative liabilities   (35,054)   36,220    1,166 
(Gain) loss on foreign currency exchange rates   (205)       (205)
Changes in assets and liabilities:               
Accounts receivable   (10,947)       (10,947)
Inventories   (126)       (126)
Prepaid expenses and other assets   (12,962)   3,233    (9,729)
Accounts payable   3,119    (1,082)   2,037 
Accrued and other liabilities   404        404 
Contract liabilities   1,113    (2,433)   (1,320)
Net cash used in operating activities   (102,652)   4,020    (98,632)
Investing activities               
Change in short-term investments   2,999        2,999 
Purchases of property, plant and equipment   (487)       (487)
Net cash (used in) provided by investing activities   2,512        2,512 
Financing activities               
Proceeds from issuance of convertible preferred stock   101,427    562    101,989 
Proceeds from exercises of common stock options   147        147 
Payment of minimum employee taxes withheld upon net share settlement of restricted stock units   (87)       (87)
Proceeds from issuance of debt, net of issuance costs   13,965        13,965 
Principal payments on debt   (26,708)       (26,708)
Net cash provided by financing activities   88,744    562    89,306 
Effect of exchange rate changes on cash, cash equivalents and restricted cash   (136)       (136)
Net (decrease) increase in cash, cash equivalents and restricted cash   (11,532)   4,582    (6,950)
Cash, cash equivalents and restricted cash at beginning of year   32,433        32,433 
Cash, cash equivalents and restricted cash at end of year  $20,901   $4,582   $25,483 
                
Reconciliation of cash, cash equivalents and restricted cash to the consolidated balance sheets               
Cash and cash equivalents  $15,865        $15,865 
Restricted cash, current   4,078         4,078 
Restricted cash, noncurrent   958         958 
Total cash, cash equivalents and restricted cash  $20,901        $20,901 

 

(1) To reflect the impact of restatement corrections on the statement of cash flows.

 

 103 

 

 

Q4 2017 Quarterly Data Restatement Adjustments

 

Condensed Consolidated Balance Sheet

 

Consolidated balance sheet as of December 31, 2017 is shown in Note 2, "Restatement of 2017 Consolidated Financial Statements".

 

Condensed Consolidated Statements of Operations

 

  Three Months Ended
December 31, 2017
  Year Ended
December 31, 2017
(In thousands, except shares and per share amounts)  As Previously Reported  Corrections  Ref  As Restated  As Previously Reported  Reclassifications(1)  Corrections  Ref  As Restated
                            
                            
Renewable products  $13,445   $      $13,445   $45,781   $(3,411)  $      $42,370 
Licenses and royalties   57,703    (14,974)  ab   42,729    57,703    6,774    (15,774)  ab   48,703 
Grants and collaborations   9,440           9,440    39,960    (3,363)   1      36,598 
Total revenue   80,588    (14,974)      65,614    143,444        (15,773)      127,671 
Cost and operating expenses                                        
Cost of products sold   15,029    676   ad   15,705    62,713        (406)  ad   62,307 
Research and development   12,815    606   ae   13,421    57,027    (72)   607   ae   57,562 
Sales, general and administrative   19,038           19,038    63,219    72    562   af   63,853 
Total cost and operating expenses   46,882    1,282       48,164    182,959        763       183,722 
Loss from operations   33,706    (16,256)      17,450    (39,515)       (16,536)      (56,051)
Other income (expense)                                         
(Loss) gain on divestiture   5,732           5,732    5,732               5,732 
Interest expense   (4,813)   (1,012)  ah   (5,825)   (34,033)       (3,048)  ah   (37,081)
(Loss) gain from change in fair value of derivative instruments   (37,164)   (10,522)  ai   (47,686)   (1,742)       (47,110)  ai   (48,852)
Loss upon extinguishment of debt   1,546           1,546    (1,521)       (10,376)  ak   (11,897)
Other income (expense), net   (380)          (380)   (955)       (1)     (956)
Total other expense, net   (35,079)   (11,534)      (46,613)   (32,519)       (60,535)      (93,054)
Loss before income taxes   (1,373)   (27,790)      (29,163)   (72,034)       (77,071)      (149,105)
Provision for income taxes   (344)   (6,582)  am   (6,926)   (295)       (6,582)  am   (6,877)
Net loss attributable to Amyris, Inc.   (1,717)   (34,372)      (36,089)   (72,329)       (83,653)      (155,982)
Less deemed dividend on capital distribution to related parties                  (8,648)       8,648   an    
Less deemed dividend related to beneficial conversion feature on Series A preferred stock                  (562)              (562)
Less deemed dividend related to beneficial conversion feature on Series B preferred stock                  (634)              (634)
Less deemed dividend related to beneficial conversion feature on Series D preferred stock                  (5,757)              (5,757)
Less deemed dividend upon settlement of make-whole provision on Series A preferred stock       (26)  ap   (26)           (10,505)  ap   (10,505)
Less deemed dividend upon settlement of make-whole provision on Series B preferred stock       (640)  aq   (640)           (22,632)  aq   (22,632)
Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series A preferred stock       (1,432)  ar   (1,432)           (21,578)  ar   (21,578)
Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series B preferred stock                          (24,366)  as   (24,366)
Less cumulative dividends on Series A and Series B preferred stock   (1,197)   1,197   aw       (5,439)       5,439   aw    
Add: losses allocated to participating securities       4,996   au   4,996            40,159   au   40,159 
Net loss attributable to Amyris, Inc. common stockholders  $(2,914)  $(30,277)     $(33,191)  $(93,369)  $   $(108,488)     $(201,857)
                                          
Loss per share attributable to common stockholders:                                         
Basic and diluted  $(0.06)          $(0.69)  $(2.89)               $(6.26)
Weighted-average shares of common stock outstanding used in computing loss per share of common stock:                                         
Basic and diluted   47,895,238            47,895,238    32,253,570                 32,253,570 

 

(1) Reclassification of revenue and operating expense by type to conform to the Company's current presentation.

 

Restatement adjustments:

ab. Ginkgo partnership obligation and promissory note issuance recorded as reduction in revenue, and reversal of revenue in connection with non-cash consideration.

ad. Correction in connection with a sales return, and adjustment to uninvoiced receipts liability.

ae. Write-off of unrecoverable receivable in connection with facilities subleased to a related party, and reclassification of operating expense by classification to conform to the Company's current presentation.

af. (i) Expense incurred in connection with May 2017 equity offering, and (ii) reclassification of amounts from related party services revenue to expense offset, and reclassification of operating expense by classification to conform to the Company's current presentation.

ah. Correction to amortization of debt discounts, and interest expense in connection with Ginkgo partnership obligation.

ai. Correction to accounting for make-whole liability in connection with May 2017 Offering.

ak. Correction to accounting for certain debt exchanges.

am. Tax provision to accrue liability for uncertain tax benefit.

an. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings.

ap. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings.

aq. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings.

ar. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings.

as. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings.

au. Correction in the computation of net loss per share to reflect participating securities.

aw. Correction in the computation of net loss per share related to make-whole deemed dividends.

 

 104 

 

 

Condensed Consolidated Statements of Cash Flows

 

Consolidated statement of cash flows for the year ended December 31, 2017 is shown in Note 2, "Restatement of 2017 Consolidated Financial Statements".

 

Q1 2018 Quarterly Data Restatement Adjustments

 

Condensed Consolidated Balance Sheet

 

    March 31, 2018
(In thousands)   As
Previously
Reported
  Corrections   Ref.   As Restated
                 
Assets                            
Current assets:                            
Cash and cash equivalents   $ 24,084     $         $ 24,084  
Restricted cash     2,454                 2,454  
Accounts receivable, net     25,730       (19,695 )   a     6,035  
Accounts receivable - related party, net           18,695     a     18,695  
Accounts receivable, unbilled - related party     9,247                 9,247  
Inventories     4,998                 4,998  
Prepaid expenses and other current assets     7,340                 7,340  
Total current assets     73,853       (1,000 )         72,853  
Property, plant and equipment, net     12,880       382     b     13,262  
Accounts receivable, unbilled - related party, noncurrent     7,940                 7,940  
Restricted cash, noncurrent     959                 959  
Recoverable taxes from Brazilian government entities     1,226                 1,226  
Other assets     21,302       (9,015 )   d     12,287  
Total assets   $ 118,160     $ (9,633 )       $ 108,527  
Liabilities, Mezzanine Equity and Stockholders' Deficit                            
Current liabilities:                            
Accounts payable   $ 16,054     $ (406 )   e   $ 15,648  
Accrued and other current liabilities     26,622       1,080     f     27,702  
Contract liabilities     6,466       2,910     g     9,376  
Debt, current portion     34,252       1,698     h     35,950  
Related party debt, current portion     27,171                 27,171  
Total current liabilities     110,565       5,282           115,847  
Long-term debt, net of current portion     62,489       (2,027 )   h     60,462  
Related party debt, net of current portion     39,147                 39,147  
Derivative liabilities     183,189       (9,037 )   l     174,152  
Other noncurrent liabilities     8,981       13,455     m     22,436  
Total liabilities     404,371       7,673           412,044  
Commitments and contingencies                            
Mezzanine equity:                            
Contingently redeemable common stock     5,000                 5,000  
Stockholders’ deficit:                            
Common stock - $0.0001 par value     5                 5  
Additional paid-in capital     1,050,587       66,272     n     1,116,859  
Accumulated other comprehensive loss     (42,293 )               (42,293 )
Accumulated deficit     (1,300,447 )     (83,578 )   p     (1,384,025 )
Total Amyris, Inc. stockholders’ deficit     (292,148 )     (17,306 )         (309,454 )
Noncontrolling interest     937                 937  
Total stockholders' deficit     (291,211 )     (17,306 )         (308,517 )
Total liabilities, mezzanine equity and stockholders' deficit   $ 118,160     $ (9,633 )       $ 108,527  

 

Restatement adjustments:

a. Reclassification of related party accounts receivable to a separate line on the balance sheet and a shift in revenue recognition and accounts receivable recognition timing.

b. Revision to capitalization of internal labor cost.

d. Reversal of the fair value of an equity instrument received as consideration in a revenue arrangement.

e. Correction to uninvoiced receipts liability.

f. Liability in connection with December 2017 divestiture of Amyris Brasil Ltda.

g. Revision to accounting for a license sale to a customer for which the customer paid the Company in equity, and shift in timing of royalty revenue recognition.

h. Correction to debt discount amortization.

l. Correction to extinguishment accounting for a make-whole equity instrument, and loss on extinguishment of related party debt in connection with May 2017 equity offering.

m. Income tax liability and Ginkgo partnership liability.

n. Correction to the settlement of a make-whole equity instrument, and loss on extinguishment of related party debt in connection with May 2017 equity offering.

p. Cumulative impact of restatement corrections on accumulated deficit.

 

 105 

 

 

Condensed Consolidated Statements of Operations

 

  Three Months Ended
March 31, 2018
(In thousands, except shares and per share amounts)   As Previously Reported   Corrections   Ref   As Restated
Renewable products   $ 5,195     $         $ 5,195  
Licenses and royalties     11,437       (3,482 )   ab     7,955  
Grants and collaborations     6,366       (1,657 )   ac     4,709  
Total revenue     22,998       (5,139 )         17,859  
Cost and operating expenses                            
Cost of products sold     5,315                 5,315  
Research and development     18,813       (988 )   ae     17,825  
Sales, general and administrative     18,757       (657 )   af     18,100  
Total cost and operating expenses     42,885       (1,645 )         41,240  
Loss from operations     (19,887 )     (3,494 )         (23,381 )
Other income (expense)                            
(Loss) gain on divestiture           (1,778 )   ag     (1,778 )
Interest expense     (8,205 )     (1,773 )   ah     (9,978 )
(Loss) gain from change in fair value of derivative instruments     (63,913 )     5,556     ai     (58,357 )
Other income (expense), net     509       183     al     692  
Total other expense, net     (71,609 )     2,188           (69,421 )
Loss before income taxes     (91,496 )     (1,306 )         (92,802 )
Provision for income taxes                      
Net loss attributable to Amyris, Inc.     (91,496 )     (1,306 )         (92,802 )
Less cumulative dividends on Series A and Series B preferred stock     (395 )     395     aw      
Add: losses allocated to participating securities           7,504     au     7,504  
Net loss attributable to Amyris, Inc. common stockholders   $ (91,891 )   $ 6,593         $ (85,298 )
                             
Loss per share attributable to common stockholders:                            
Basic and diluted   $ (1.79 )               $ (1.67 )
Weighted-average shares of common stock outstanding used in computing loss per share of common stock:                            
Basic and diluted     51,200,922                   51,200,922  

 

Restatement adjustments:

ab. Reduction to revenue previously recognized in connection with DSM royalty revenue arrangement.

ac. Reclassification of a related party transaction from collaboration revenue to expense offset.

ae. Write-off of unrecoverable receivable in connection with facilities subleased to a related party, and revision to capitalization of internal labor cost.

af. Expense incurred in connection with May 2017 equity offering, and reclassification of amounts from related party services revenue to expense offset.

ag. Loss incurred in 2018 on December 2017 divestiture of Amyris Brasil Ltda.

ah. Correction to amortization of debt discounts, and interest expense in connection with Ginkgo partnership obligation.

ai. Adjustments to change in fair value of derivative liabilities in connection with May and August 2017 equity offerings.

al. Revision to accounting for shares received in satisfaction of a 2017 revenue arrangement, equity issuance costs recorded as expense, and adjustment to gain (loss) on change in accumulated other comprehensive income.

au. Correction in the computation of net loss per share to reflect participating securities.

aw. Correction in the computation of net loss per share related to make-whole deemed dividends.

 

 106 

 

 

Condensed Consolidated Statements of Cash Flows

 

    Three Months Ended March 31, 2018
(In thousands)   As Previously Reported   Corrections(1)   As Restated
Operating activities                        
Net loss   $ (91,496 )     (1,306 )   $ (92,802 )
Adjustments to reconcile net loss to net cash used in operating activities:                        
Depreciation and amortization     1,561             1,561  
Gain on change in fair value of equity investment     (315 )     315        
(Gain) loss on disposal of property, plant and equipment     1,035             1,035  
Stock-based compensation     1,278             1,278  
Amortization of debt discount     3,016       1,773       4,789  
(Gain) loss from change in fair value of derivative liabilities     63,913       (5,556 )     58,357  
(Gain) loss on foreign currency exchange rates     243             243  
Changes in assets and liabilities:                        
Accounts receivable     (926 )     1,000       74  

Accounts receivable, unbilled – related party

    93             93  
Inventories     420             420  
Prepaid expenses and other assets     (2,268 )     9,015       6,747  
Accounts payable     (108 )           (108 )
Accrued and other liabilities     (2,779 )     (8,341 )     (11,120 )
Contract liabilities     782       3,482       4,264  
Net cash used in operating activities     (25,551 )     382       (25,169 )
Investing activities                        
Purchases of property, plant and equipment     (1,202 )     (382 )     (1,584 )
Net cash (used in) provided by investing activities     (1,202 )     (382 )     (1,584 )
Financing activities                        
Proceeds from exercises of common stock options     81             81  
Payment of minimum employee taxes withheld upon net share settlement of restricted stock units     (66 )           (66 )
Principal payments on capital leases     (400 )           (400 )
Principal payments on debt     (6,534 )           (6,534 )
Proceeds from exercise of warrants     133             133  
Proceeds from issuance of common stock in private placements, net of issuance costs     92             92  
Net cash provided by financing activities     (6,694 )           (6,694 )
Effect of exchange rate changes on cash, cash equivalents and restricted cash     (68 )           (68 )
Net (decrease) increase in cash, cash equivalents and restricted cash     (33,515 )           (33,515 )
Cash, cash equivalents and restricted cash at beginning of year     61,012             61,012  
Cash, cash equivalents and restricted cash at end of year   $ 27,497     $     $ 27,497  
                         
Reconciliation of cash, cash equivalents and restricted cash to the consolidated balance sheets                        
Cash and cash equivalents   $ 24,084             $ 24,084  
Restricted cash, current     2,454               2,454  
Restricted cash, noncurrent     959               959  
Total cash, cash equivalents and restricted cash   $ 27,497             $ 27,497  

 

(1) To reflect the impact of restatement corrections on the statement of cash flows.

 

 

 107 

 

 

Q2 2018 Quarterly Data Restatement Adjustments

 

Condensed Consolidated Balance Sheet

 

    June 30, 2018
(In thousands)   As Previously Reported   Corrections   Ref.   As Restated
Assets                            
Current assets:                            
Cash and cash equivalents   $ 14,050     $         $ 14,050  
Restricted cash     1,846                 1,846  
Short-term investments     130                 130  
Accounts receivable, net     26,814       (17,247 )   a     9,567  
Accounts receivable - related party, net           4,265     a     4,265  
Accounts receivable, unbilled - related party     12,683                 12,683  
Inventories     6,632                 6,632  
Prepaid expenses and other current assets     4,687                 4,687  
Total current assets     66,842       (12,982 )         53,860  
Property, plant and equipment, net     15,300                 15,300  

Accounts receivable, unbilled, noncurrent – related party

    9,747                 9,747  
Deferred cost of products sold, noncurrent – related party                      
Restricted cash, noncurrent     959                 959  
Recoverable taxes from Brazilian government entities     1,057                 1,057  
Other assets     24,747       (10,418 )   d     14,329  
Total assets   $ 118,652     $ (23,400 )       $ 95,252  
Liabilities, Mezzanine Equity and Stockholders' Deficit                            
Current liabilities:                            
Accounts payable   $ 19,206     $         $ 19,206  
Accrued and other current liabilities     20,101       2,645     f     22,746  
Contract liabilities     9,643       (2,672 )   g     6,971  
Debt, current portion     59,987       118     h     60,105  
Related party debt, current portion     49,669                 49,669  
Total current liabilities     158,606       91           158,697  
Long-term debt, net of current portion     43,642       121     h     43,763  
Related party debt, net of current portion     18,104       (270 )   k     17,834  
Derivative liabilities     138,695       (4,850 )   l     133,845  
Other noncurrent liabilities     8,581       13,492     m     22,073  
Total liabilities     367,628       8,584           376,212  
Commitments and contingencies                            
Mezzanine equity:                            
Contingently redeemable common stock     5,000                 5,000  
Stockholders’ deficit:                            
Common stock - $0.0001 par value     5                 5  
Additional paid-in capital     1,086,814       67,811     n     1,154,625  
Accumulated other comprehensive loss     (42,818 )     (302 )   o     (43,120 )
Accumulated deficit     (1,298,914 )     (99,493 )   p     (1,398,407 )
Total Amyris, Inc. stockholders’ deficit     (254,913 )     (31,984 )         (286,897 )
Noncontrolling interest     937                 937  
Total stockholders' deficit     (253,976 )     (31,984 )         (285,960 )
Total liabilities, mezzanine equity and stockholders' deficit   $ 118,652     $ (23,400 )       $ 95,252  

 

Restatement adjustments:

a. Reclassification of related party accounts receivable to a separate line on the balance sheet, and revision to accounting for a related party royalties arrangement.

d. Reversal of prepaid royalty asset related to Ginkgo Partnership promissory note and the fair value of an equity instrument received as consideration in a revenue arrangement.

f. Liability in connection with December 2017 divestiture of Amyris Brasil Ltda.

g. Revision to accounting for a license sale to a customer for non-cash consideration, and shift in timing of royalty revenue recognition.

h. Correction to debt discount amortization.

l. Correction to extinguishment accounting for a make-whole equity instrument, and loss on extinguishment of related party debt in connection with May 2017 equity offering.

m. Income tax and Ginkgo partnership obligation liabilities.

n. Correction to the settlement of a make-whole equity instrument, and loss on extinguishment of related party debt in connection with May 2017 equity offering.

o. Correction to accumulated other comprehensive loss related to foreign currency translation gains / losses.

p. Cumulative impact of restatement corrections on accumulated deficit.

 

 108 

 

 

Condensed Consolidated Statements of Operations

 

  Three Months Ended
June 30, 2018
  Six Months Ended
June 30, 2018
(In thousands, except shares and per share amounts)  As Previously Reported  Corrections  Ref  As Restated  As Previously Reported  Corrections  Ref  As Restated
                         
                         
Renewable products  $6,633   $      $6,633   $11,828   $      $11,828 
Licenses and royalties   6,887    (7,400)  ab   (513)   18,324    (10,882)  ab   7,442 
Grants and collaborations   9,674    (735)  ac   8,939    16,040    (2,392)  ac   13,648 
Total revenue   23,194    (8,135)      15,059    46,192    (13,274)      32,918 
Cost and operating expenses                                    
Cost of products sold   5,984    550   ad   6,534    11,299    550   ad   11,849 
Research and development   15,287    382   ae   15,669    34,100    (606)  ae   33,494 
Sales, general and administrative   20,189    (735)  af   19,454    38,946    (1,392)  af   37,554 
Total cost and operating expenses   41,460    197       41,657    84,345    (1,448)      82,897 
Loss from operations   (18,266)   (8,332)      (26,598)   (38,153)   (11,826)      (49,979)
Other income (expense)                                    
(Loss) gain on divestiture                      (1,778)  ag   (1,778)
Interest expense   (8,824)   (756)  ah   (9,580)   (17,029)   (2,529)  ah   (19,558)
(Loss) gain from change in fair value of derivative instruments   24,365    (2,375)  ai   21,990    (39,548)   3,181   ai   (36,367)
Gain upon extinguishment of derivative liability   1,857    (1,857)  aj       1,857    (1,857)  aj    
Loss upon extinguishment of debt   (26)          (26)   (26)          (26)
Other income (expense), net   2,427    (2,595)  al   (168)   2,936    (2,412)  al   524 
Total other expense, net   19,799    (7,583)      12,216    (51,810)   (5,395)      (57,205)
Loss before income taxes   1,533    (15,915)      (14,382)   (89,963)   (17,221)      (107,184)
Provision for income taxes                              
Net loss attributable to Amyris, Inc.   1,533    (15,915)      (14,382)   (89,963)   (17,221)      (107,184)
Less cumulative dividends on Series A and Series B preferred stock   (399)   399   aw       (794)   794   aw    
Add: losses allocated to participating securities   (67)   1,037   au   970    (67)   7,999   au   7,932 
Net loss attributable to Amyris, Inc. common stockholders  $1,067   $(14,479)     $(13,412)  $(90,824)  $(8,428)     $(99,252)
                                     
Loss per share attributable to common stockholders:                                    
Basic and diluted  $0.02           $(0.24)  $(1.71)          $(1.87)
Weighted-average shares of common stock outstanding used in computing loss per share of common stock:                                    
Basic and diluted   54,932,411            54,932,411    53,076,975            53,076,975 

 

 

Restatement adjustments:

ab. Reduction to revenue previously recognized in connection with DSM royalty revenue arrangement.

ac. Reclassification of a related party transaction from collaboration revenue to expense offset.

ad. Adjustment to uninvoiced receipts liability, and revision in connection with change in timing of revenue recognition.

ae. Write-off of unrecoverable receivable in connection with facilities subleased to a related party, and revision to capitalization of internal labor cost.

af. Expense incurred in connection with May 2017 equity offering, and reclassification of amounts from related party services revenue to expense offset.

ag. Loss incurred in 2018 in connection with the December 2017 divestiture of Amyris Brasil Ltda.

ah. Correction to amortization of debt discounts, and interest expense in connection with various debt instruments.

ai. Correction to accounting for settlement of a make-whole equity instrument in connection with May 2017 equity offering.

aj. Reclassification to (loss) gain from change in fair value of derivative instruments.

al. Revision to accounting for shares received in satisfaction of a 2017 revenue arrangement, equity issuance costs recorded as expense, and adjustment to gain (loss) on change in accumulated other comprehensive income.

au. Correction in the computation of net loss per share to reflect participating securities.

aw. Correction in the computation of net loss per share related to make-whole deemed dividends.

 

 109 

 

 

Condensed Consolidated Statements of Cash Flows

 

    Six Months Ended June 30, 2018
(In thousands)   As Previously Reported   Corrections(1)   As Restated
Operating activities                        
Net loss   $ (89,963 )     (17,221 )   $ (107,184 )
Adjustments to reconcile net loss to net cash used in operating activities:                        
Depreciation and amortization     2,944             2,944  
Gain on change in fair value of equity investment     (1,717 )     1,717        
(Gain) loss on disposal of property, plant and equipment     942             942  
Stock-based compensation     3,178             3,178  
Amortization of debt discount     6,587       1,642       8,229  
(Gain) loss upon extinguishment of debt     26             26  
Receipt of equity in connection with collaboration arrangements revenue                      
(Gain) loss from change in fair value of derivative liabilities     39,548       (3,181 )     36,367  
(Gain) loss from extinguishment of derivative liabilities     (1,857 )     1,857        
(Gain) loss on foreign currency exchange rates     271       (302 )     (31 )
Changes in assets and liabilities:                        
Accounts receivable     (2,027 )     12,983       10,956  

Accounts receivable, unbilled – related party

    (5,150 )           (5,150 )
Inventories     (1,313 )           (1,313 )
Deferred cost of products sold                  
Prepaid expenses and other assets     (1,072 )     (606 )     (1,678 )
Accounts payable     2,681       406       3,087  
Accrued and other liabilities     (10,031 )     3,311       (6,720 )
Contract liabilities     3,959       (2,100 )     1,859  
Net cash used in operating activities     (52,994 )     (1,494 )     (54,488 )
Investing activities                        
Change in short-term investments     (157 )           (157 )
Purchases of property, plant and equipment     (4,207 )           (4,207 )
Net cash (used in) provided by investing activities     (4,364 )           (4,364 )
Financing activities                        
Proceeds from exercises of common stock options     248             248  
Payment of minimum employee taxes withheld upon net share settlement of restricted stock units     (185 )           (185 )
Principal payments on capital leases     (593 )           (593 )
Proceeds from issuance of debt, net of issuance costs     34,611       1,494       36,105  
Principal payments on debt     (37,037 )           (37,037 )
Proceeds from exercise of warrants     14,549             14,549  
Proceeds from issuance of common stock in private placements, net of issuance costs     1,416             1,416  
Proceeds from ESPP purchases     270             270  
Net cash provided by financing activities     13,279       1,494       14,773  
Effect of exchange rate changes on cash, cash equivalents and restricted cash     (78 )           (78 )
Net (decrease) increase in cash, cash equivalents and restricted cash     (44,157 )           (44,157 )
Cash, cash equivalents and restricted cash at beginning of year     61,012             61,012  
Cash, cash equivalents and restricted cash at end of year   $ 16,855     $     $ 16,855  
                         
Reconciliation of cash, cash equivalents and restricted cash to the consolidated balance sheets                        
Cash and cash equivalents   $ 14,050             $ 14,050  
Restricted cash, current     1,846               1,846  
Restricted cash, noncurrent     959               959  
Total cash, cash equivalents and restricted cash   $ 16,855             $ 16,855  

 

(1) To reflect the impact of restatement corrections on the statement of cash flows.

 

 110 

 

 

Q3 018 Quarterly Data Restatement Adjustments

 

Condensed Consolidated Balance Sheet

 

    September 30, 2018
(In thousands)   As Previously Reported   Corrections   Ref.   As Restated
Assets                            
Current assets:                            
Cash and cash equivalents   $ 19,045     $         $ 19,045  
Restricted cash     1,258                 1,258  
Accounts receivable, net     35,564       (20,563 )   a     15,001  
Accounts receivable - related party, net           7,581     a     7,581  
Accounts receivable, unbilled- related party     56                 56  
Inventories     6,260                 6,260  
Prepaid expenses and other current assets     5,541                 5,541  
Total current assets     67,724       (12,982 )         54,742  
Property, plant and equipment, net     16,622                 16,622  
Accounts receivable, unbilled, noncurrent - related party     9,767                 9,767  
Restricted cash, noncurrent     959                 959  
Recoverable taxes from Brazilian government entities     1,053                 1,053  
Other assets     26,557       (12,161 )   d     14,396  
Total assets   $ 122,682     $ (25,143 )       $ 97,539  
Liabilities, Mezzanine Equity and Stockholders' Deficit                            
Current liabilities:                            
Accounts payable   $ 11,380     $         $ 11,380  
Accrued and other current liabilities     27,263       10,448     f     37,711  
Contract liabilities     6,698       (2,672 )   g     4,026  
Debt, current portion     61,904       152     h     62,056  
Related party debt, current portion     47,020                 47,020  
Total current liabilities     154,265       7,928           162,193  
Long-term debt, net of current portion     43,667       121     j     43,788  
Related party debt, net of current portion     18,526       (270 )   j     18,256  
Derivative liabilities     98,662       (5,101 )   l     93,561  
Other noncurrent liabilities     8,152       13,141     m     21,293  
Total liabilities     323,272       15,819           339,091  
Commitments and contingencies                            
Mezzanine equity:                            
Contingently redeemable common stock     5,000                 5,000  
Stockholders’ deficit:                            
Common stock - $0.0001 par value     6                 6  
Additional paid-in capital     1,202,850       65,829     n     1,268,679  
Accumulated other comprehensive loss     (42,148 )     (1,166 )   o     (43,314 )
Accumulated deficit     (1,367,235 )     (105,625 )   p     (1,472,860 )
Total Amyris, Inc. stockholders’ deficit     (206,527 )     (40,962 )         (247,489 )
Noncontrolling interest     937                 937  
Total stockholders' deficit     (205,590 )     (40,962 )         (246,552 )
Total liabilities, mezzanine equity and stockholders' deficit   $ 122,682     $ (25,143 )       $ 97,539  

 

Restatement adjustments:

a. Reclassification of related party accounts receivable to a separate line on the balance sheet, and revision to accounting for a related party royalties arrangement.

d. Reversal of revenue and the fair value of an equity instrument received as consideration in a revenue arrangement.

f. Liability related to modification of warrants recorded as legal expense, and liability in connection with December 2017 divestiture of Amyris Brasil Ltda.

g. Revision to accounting for a related party royalties arrangement, and revision to accounting for a license sale to a customer for non-cash consideration.

h. Correction to debt discount amortization.

j. Correction to debt discount amortization.

l. Correction to extinguishment accounting for a make-whole equity instrument.

m. Income tax and Ginkgo partnership obligation liabilities.

n. Correction to the settlement of a make-whole equity instrument, and loss on extinguishment of related party debt in connection with May 2017 equity offering.

o. Correction to accumulated other comprehensive loss related to foreign currency translation gains / losses.

p. Cumulative impact of restatement corrections on accumulated deficit.

 

 111 

 

 

Condensed Consolidated Statements of Operations

 

  Three Months Ended
September 30, 2018
  Nine Months Ended
September 30, 2018
(In thousands, except shares and per share amounts)  As Previously Reported  Corrections  Ref  As Restated  As Previously Reported  Corrections  Ref  As Restated
                         
                         
Renewable products  $9,639   $      $9,639   $21,467   $      $21,467 
Licenses and royalties   142           142    18,466    (10,882)  ab   7,584 
Grants and collaborations   5,085    (551)  ac   4,534    21,125    (2,943)  ac   18,182 
Total revenue   14,866    (551)      14,315    61,058    (13,825)      47,233 
Cost and operating expenses                                    
Cost of products sold   8,574           8,574    19,873    550   ad   20,423 
Research and development   16,445           16,445    50,545    (606)  ae   49,939 
Sales, general and administrative   21,026    6,213   af   27,239    59,972    4,821   af   64,793 
Total cost and operating expenses   46,045    6,213       52,258    130,390    4,765       135,155 
Loss from operations   (31,179)   (6,764)      (37,943)   (69,332)   (18,590)      (87,922)
Other income (expense)                                    
(Loss) gain on divestiture                      (1,778)  ag   (1,778)
Interest expense   (8,658)   (522)  ah   (9,180)   (25,687)   (3,051)  ah   (28,738)
(Loss) gain from change in fair value of derivative instruments   (25,048)   251   ai   (24,797)   (64,596)   3,432   ai   (61,164)
Gain upon extinguishment of derivative liability   (1,782)   1,782   aj       75    (75)  aj    
Loss upon extinguishment of debt                  (26)          (26)
Other income (expense), net   (1,654)   (879)  al   (2,533)   1,282    (3,291)  al   (2,009)
Total other expense, net   (37,142)   632       (36,510)   (88,952)   (4,763)      (93,715)
Loss before income taxes   (68,321)   (6,132)      (74,453)   (158,284)   (23,353)      (181,637)
Provision for income taxes                              
Net loss attributable to Amyris, Inc.   (68,321)   (6,132)      (74,453)   (158,284)   (23,353)      (181,637)
Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series D preferred stock       (6,852)  at   (6,852)       (6,852)  at   (6,852)
Less cumulative dividends on Series A and Series B preferred stock   (279)   279   aw       (1,073)   1,073   aw    
Add: losses allocated to participating securities       4,491   au   4,491    (67)   12,891   au   12,824 
Net loss attributable to Amyris, Inc. common stockholders  $(68,600)  $(8,214)     $(76,814)  $(159,424)  $(16,241)     $(175,665)
                                     
Loss per share attributable to common stockholders:                                    
Basic and diluted  $(1.13)  $(0.13)     $(1.26)  $(2.86)  $(0.29)     $(3.15)
Weighted-average shares of common stock outstanding used in computing loss per share of common stock:                                    
Basic and diluted   60,966,071            60,966,071    55,735,571            55,735,571 

 

Restatement adjustments:
ab. Reduction to revenue previously recognized in connection with DSM royalty revenue arrangement.

ac. Reclassification of a related party transaction from collaboration revenue to expense offset.

ad. Adjustment to uninvoiced receipts liability.

ae. Write-off of unrecoverable receivable in connection with facilities subleased to a related party.

af. Expense incurred in connection with warrant exercise in August 2018, and reclassification of amounts from related party services revenue to expense offset.

ag. Loss incurred in 2018 on December 2017 divestiture of Amyris Brasil Ltda.

ah. Interest expense in connection with various debt instruments.

ai. Adjustments to change in fair value of derivative liabilities in connection with May and August 2017 equity offerings.

aj. Correction to extinguishment accounting for a make-whole equity instrument.

al. Revision to accounting for shares received in satisfaction of a 2017 revenue arrangement, equity issuance costs recorded as expense, and adjustment to gain (loss) on change in accumulated other comprehensive income.

at. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings.

au. Correction in the computation of net loss per share to reflect participating securities.

aw. Correction in the computation of net loss per share related to make-whole deemed dividends.

 

 112 

 

 

Condensed Consolidated Statements of Cash Flows

 

    Nine Months Ended September 30, 2018
(In thousands)   As Previously Reported   Corrections(1)   As Restated
Operating activities                        
Net loss   $ (158,284 )     (23,353 )   $ (181,637 )
Adjustments to reconcile net loss to net cash used in operating activities:                        
Depreciation and amortization     3,957             3,957  
Gain on change in fair value of equity investment     (3,460 )     3,460        
(Gain) loss on disposal of property, plant and equipment     943             943  
Stock-based compensation     6,115             6,115  
Amortization of debt discount     10,568       1,676       12,244  
(Gain) loss upon extinguishment of debt     26             26  
(Gain) loss from change in fair value of derivative liabilities     64,596       (3,432 )     61,164  
(Gain) loss from extinguishment of derivative liabilities     (75 )     75          
(Gain) loss on foreign currency exchange rates     34       (1,166 )     (1,132 )
Changes in assets and liabilities:                        
Accounts receivable     (10,756 )     12,982       2,226  

Accounts receivable, unbilled – related party

    7,457             7,457  
Inventories     (890 )           (890 )
Prepaid expenses and other assets     (1,781 )     (606 )     (2,387 )
Accounts payable     (5,201 )     406       (4,795 )
Accrued and other liabilities     (2,216 )     10,564       8,348  
Contract liabilities     1,014       (2,100 )     (1,086 )
Net cash used in operating activities     (87,953 )     (1,494 )     (89,447 )
Investing activities                        
Purchases of property, plant and equipment     (6,362 )           (6,362 )
Net cash (used in) provided by investing activities     (6,362 )           (6,362 )
Financing activities                        
Proceeds from exercises of common stock options     301             301  
Payment of minimum employee taxes withheld upon net share settlement of restricted stock units     (196 )           (196 )
Principal payments on capital leases     (848 )           (848 )
Proceeds from issuance of debt, net of issuance costs     35,149       1,494       36,643  
Principal payments on debt     (41,970 )           (41,970 )
Proceeds from exercise of warrants     60,544             60,544  
Proceeds from issuance of common stock in private placements, net of issuance costs     1,416             1,416  
Proceeds from ESPP purchases     270             270  
Net cash provided by financing activities     54,666       1,494       56,160  
Effect of exchange rate changes on cash, cash equivalents and restricted cash     (101 )           (101 )
Net (decrease) increase in cash, cash equivalents and restricted cash     (39,750 )           (39,750 )
Cash, cash equivalents and restricted cash at beginning of year     61,012             61,012  
Cash, cash equivalents and restricted cash at end of year   $ 21,262     $     $ 21,262  
                         
Reconciliation of cash, cash equivalents and restricted cash to the consolidated balance sheets                        
Cash and cash equivalents   $ 19,045             $ 19,045  
Restricted cash, current     1,258               1,258  
Restricted cash, noncurrent     959               959  
Total cash, cash equivalents and restricted cash   $ 21,262             $ 21,262  

 

(1) To reflect the impact of restatement corrections on the statement of cash flows.

 

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ITEM 9A. CONTROLS AND PROCEDURES

 

As described in additional detail in the Explanatory Note to this Annual Report on Form 10-K, in May 2019, our Board, upon the recommendation of the Audit Committee after consultation with senior management, concluded that there were material misstatements in our audited consolidated financial statements for the year ended December 31, 2017. Accordingly, our Board and senior management concluded that our audited consolidated financial statements for the year ended December 31, 2017 should no longer be relied upon and required restatement. The restated audited consolidated financial statements for year ended December 31, 2017 are provided in this Annual Report on Form 10-K.

 

  (a) Evaluation of Disclosure Controls and Procedures

 

We maintain disclosure controls and procedures (as that term is defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934 (the Exchange Act) that are designed to provide reasonable assurance that information required to be disclosed in our reports under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the U.S. Securities and Exchange Commission’s rules and forms, and that such information is accumulated and communicated to our management, including our principal executive officer (CEO) and interim chief financial officer (CFO) and, as appropriate, to allow timely decisions regarding required disclosures.

 

In connection with the preparation of this Annual Report on Form 10-K, we carried out an evaluation under the supervision of and with the participation of management, including our CEO and CFO, as of December 31, 2018, of the effectiveness of the design and operation of our disclosure controls and procedures. Based upon this evaluation, our CEO and CFO concluded that as of December 31, 2018, our disclosure controls and procedures were not effective because of the material weaknesses in our internal control over financial reporting described below.

 

Notwithstanding the existence of the material weaknesses described below, management performed additional analysis and other procedures to ensure that our consolidated financial statements were prepared in accordance with U.S. GAAP. Accordingly, management believes that the consolidated financial statements and disclosures included in this Annual Report on Form 10-K fairly present, in all material respects, in accordance with U.S. GAAP, our financial position, results of operations and cash flows for the periods presented.

 

  (b) Management’s Annual Report on Internal Control over Financial Reporting

 

Our management is responsible for establishing and maintaining adequate internal control over financial reporting and for the assessment of the effectiveness of internal control over financial reporting as defined in Rule 13a-15(f) under the Exchange Act. Our internal control over financial reporting is a process designed by and under the supervision of our CEO and CFO and effected by our board of directors, management, and other personnel, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of our consolidated financial statements for external purposes in accordance with U.S. GAAP. Our internal control over financial reporting includes those policies and procedures that (1) pertain to the maintenance of records that in reasonable detail accurately and fairly reflect the transactions and dispositions of the assets of the Company; (2) provide reasonable assurance that transactions are recorded as necessary to permit preparation of the financial statements in accordance with U.S. GAAP, and that receipts and expenditures of the Company are being made only in accordance with authorizations of management and directors of company; and (3) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use or disposition of the Company’s assets that could have a material effect on the financial statements.

 

 114 

 

 

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies and procedures may deteriorate.

 

A “material weakness” is a deficiency, or combination of deficiencies, in internal control over financial reporting, such that there is a reasonable possibility that a material misstatement of our annual or interim financial statements will not be prevented or detected on a timely basis.

 

Management, under the supervision of our CEO and CFO, and oversight of the board of directors, conducted an assessment of the effectiveness of our internal control over financial reporting as of December 31, 2018, based on the criteria set forth in Internal Control–Integrated Framework (2013) issued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO 2013 Framework). Based on this assessment, management has identified deficiencies in our internal controls over financial reporting that contributed to the identified material weaknesses described below:

 

  The Company’s control environment is not effective because the Company lacked a sufficient number of trained resources with assigned responsibility and accountability over the application of generally accepted accounting principles and financial reporting and related internal controls over complex, significant non-routine transactions and routine transactions;

 

  The Company did not have an effective risk assessment process to identify and analyze necessary changes in business operations resulting from complex significant non-routine transactions and completeness and adequacy of required disclosures;

 

  The Company did not have an effective internal and external information and communication process to ensure that relevant and reliable information was communicated timely across the organization, to enable financial personnel to effectively carry out their financial reporting and internal control roles and responsibilities; and

 

  The Company did not design, implement and operate effective monitoring activities over complex, significant non-routine transactions and the accounting for income taxes to ascertain whether the processes and internal controls were present and functioning.

 

As a consequence of the ineffective control environment, risk assessment, information and communication and monitoring activities components, the Company did not design, implement, and maintain effective control activities at the transaction level over all significant accounts to mitigate the risk of material misstatement in financial reporting, specifically:

 

  The Company did not retain the required documentation to demonstrate the consistent and timely operation of the controls at a sufficient level of precision to prevent and detect potential misstatements; and

 

  The Company did not design and operate effective controls over account reconciliations, review and approval of manual journal entries, complex, significant non-routine transactions related to licenses and royalty revenue recognition, derivative liabilities, NOL carryforward limitations, currency translation adjustments and the completeness and accuracy and timely preparation of financial statement presentation and disclosures, including earnings per share.

 

The control deficiencies create a reasonable possibility that a material misstatement of our annual or interim consolidated financial statements would not be prevented or detected on a timely basis. Therefore, we concluded that these control deficiencies are material weaknesses and our internal control over financial reporting is not effective as of December 31, 2018.

 

The Company’s independent registered public accounting firm, Macias, Gini & O’Connell LLP, who audited the December 31, 2018 consolidated financial statements included in this annual report, has issued an adverse audit report on the effectiveness of the Company’s internal control over financial reporting as of December 31, 2018. Macias, Gini & O’Connell LLP's report appears under Part II, Item 8 of this Annual Report on Form 10-K.

 

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  (c) Changes in Internal Control over Financial Reporting

 

Except for the material weaknesses discussed above in this Item 9A that were identified in the fourth quarter (and that arose in an earlier period), there were no changes in our internal control over financial reporting during the fourth quarter of 2018 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

 

  (d) Remediation Plan

 

Management has begun implementing the plan to assess risks of material misstatement over financial reporting, including the enhancement of internal control activities, and training of key process owners. The plan will be accomplished by the execution of the following:

 

  Management will augment the finance and accounting function with qualified personnel commensurate with the complexity of our processes and financial reporting requirements. Management will review the assignment of roles and responsibilities to qualified personnel to ensure our financial reporting objectives are met.

 

  Management will ensure key process owners and other relevant personnel are adequately trained on our financial reporting processes and internal controls to ensure such processes and controls are performed timely and supported with adequate documentation evidencing control performance.

 

  Management will enhance internal communication processes through the formalization of internal control documentation and related documentation standards.

 

  Management will formalize and strengthen our oversight and monitoring controls to assess the effective functioning of controls over all components and functional areas of the organization and to monitor compliance with policies and procedures.

 

  Management will document and augment key policies and internal control procedures to strengthen our identification of and accounting for complex, significant non-routine transactions and routine transactions.

 

We believe these activities will remediate the control deficiencies identified above and strengthen our internal controls over financial reporting. Management, with the oversight of the Audit Committee, has dedicated incremental resources to successfully implement and test effectiveness of the enhanced controls throughout 2019 and into 2020.

 

As we continue to evaluate and work to improve our internal control over financial reporting, management may determine to take additional measures to address control deficiencies or determine to modify the remediation plan described above. We cannot be certain, however, that we will effectively remediate such material weaknesses or when we will do so, nor can we be certain of whether additional actions will be required or the costs of any such actions. In designing and evaluating disclosure controls and procedures and internal control over financial reporting, management recognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving the desired control objectives. In addition, the design of disclosure controls and procedures and internal control over financial reporting must reflect the fact that there are resource constraints and that management is required to apply judgement in evaluating the benefits of possible controls and procedures relative to their costs.

 

 116 

 

 

Report of Independent Registered Public Accounting Firm

 

To the Board of Directors and Stockholders of Amyris, Inc.

 

Opinion on Internal Control over Financial Reporting

 

We have audited the internal control over financial reporting of Amyris, Inc. and Subsidiaries (the “Company”) as of December 31, 2018, based on criteria established in Internal Control - Integrated Framework (2013) issued by the Committee of Sponsoring Organizations of the Treadway Commission (the “COSO criteria”). In our opinion, the Company did not maintain, in all material respects, effective internal control over financial reporting as of December 31, 2018, based on the COSO criteria.

 

We do not express an opinion or any other form of assurance on management’s statements referring to any corrective actions taken by the Company after the date of management’s assessment.

 

We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States) (“PCAOB”), the consolidated balance sheet as of December 31, 2018 and the related consolidated statement of operations, comprehensive loss, stockholders’ deficit and mezzanine equity and cash flow for the year end December 31, 2018, and the related notes (collectively referred to as the “consolidated financial statements”) and our report dated October 1, 2019 expressed an unqualified opinion thereon.

 

Basis for Opinion

 

The Company’s management is responsible for maintaining effective internal control over financial reporting and for its assessment of the effectiveness of internal control over financial reporting, included in the accompanying Item 9A, management’s annual report on internal control over financial reporting. Our responsibility is to express an opinion on the Company’s internal control over financial reporting based on our audit. We are a public accounting firm registered with the PCAOB and are required to be independent with respect to the Company in accordance with U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

 

We conducted our audit of internal control over financial reporting in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether effective internal control over financial reporting was maintained in all material respects. Our audit included obtaining an understanding of internal control over financial reporting, assessing the risk that a material weakness exists, and testing and evaluating the design and operating effectiveness of internal control based on the assessed risk. Our audit also included performing such other procedures as we considered necessary in the circumstances. We believe that our audit provides a reasonable basis for our opinion.

 

A material weakness is a deficiency, or a combination of deficiencies, in internal control over financial reporting, such that there is a reasonable possibility that a material misstatement of the Company’s annual or interim financial statements will not be prevented or detected on a timely basis. Several material weaknesses regarding management’s failure to design, implement and maintain internal control over financial reporting have been identified and described in management’s assessment in Item 9A. The material weaknesses related to 1) control environment, due to material weaknesses related to lack of a sufficient number of trained resources with assigned responsibility and accountability over the application of generally accepted accounting principles and financial reporting and related internal controls over complex, significant non-routine transactions and routine transactions; 2) risk assessment, as to the lack of processes to identify and analyze necessary changes in business operations resulting from complex significant non-routine transactions and completeness and adequacy of required disclosures; 3) information and communication, as to the lack of processes to ensure that relevant and reliable information was communicated timely across the organization, to enable financial personnel to effectively carry out their financial reporting and internal control roles and responsibilities and 4) monitoring, given the lack of control activities over complex, significant non-routine transactions and accounting for income taxes to ascertain whether the processes and internal controls were present and functioning. These material weaknesses contributed to additional material weaknesses with the Company not retaining the required documentation to demonstrate the consistent and timely operation of the controls at a sufficient level of precision to prevent and detect potential misstatements and did not design and operate effective controls over account reconciliations, review and approval of manual journal entries, complex, significant non-routine transactions related to licenses and royalty revenue recognition, derivative liabilities, NOL carryforward limitations, currency translation adjustments and the completeness and accuracy and timely preparation of financial statement presentation and disclosures, including earnings per share.

 

These material weaknesses were considered in determining the nature, timing, and extent of audit tests applied in our audit of the 2018 consolidated financial statements, and this report does not affect our report dated October 1, 2019 on those consolidated financial statements.

 

 117 

 

 

Definition and Limitations of Internal Control over Financial Reporting

 

A company’s internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company’s internal control over financial reporting includes those policies and procedures that (1) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of the Company; (2) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the Company are being made only in accordance with authorizations of management and directors of the Company; and (3) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use, or disposition of the Company’s assets that could have a material effect on the financial statements.

 

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

 

/s/ Macias Gini & O'Connell LLP

 

San Francisco, California

October 1, 2019

 

 

 

 

 

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PART IV

 

ITEM 15. EXHIBITS AND FINANCIAL STATEMENT SCHEDULE

 

We have filed the following documents as part of this Annual Report on Form 10-K/A:

 

  1. Financial Statements: See "Index to Consolidated Financial Statements" in Part II, Item 8 of this Annual Report on Form 10-K/A.

 

  2. Financial Statement Schedule:

a.        Allowance for doubtful accounts: see Note 3, "Balance Sheet Details" in Part II, Item 8 of this Annual Report on Form 10-K/A.

b.       Deferred tax assets valuation allowance: see Note 14, "Income Taxes" in Part II, Item 8 of this Annual Report on Form 10-K/A.

 

  3. Exhibits: See "Index to Exhibits" immediately following the signature page of this Annual Report on Form 10-K/A.

 

  

 

 

 

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SIGNATURES

 

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

 

    AMYRIS, INC.
     
  By: /s/ Jonathan Wolter
    Jonathan Wolter
    Interim Chief Financial Officer
    October 4, 2019

 

 

 

 120 

 

 

INDEX TO EXHIBITS

 

Exhibit
No.
Description
2.01 a Quota Purchase Agreement, dated November 17, 2017, among registrant, AB Technologies LLC and DSM Produtos Nutricionais Brasil S.A.
2.02 Amendment No. 1, dated December 28, 2017, to the Quota Purchase Agreement, dated November 17, 2017, among registrant, AB Technologies LLC and DSM Produtos Nutricionais Brasil S.A.
3.01 Restated Certificate of Incorporation
3.02 Certificate of Amendment, dated May 9, 2013, to Restated Certificate of Incorporation
3.03 Certificate of Amendment, dated May 12, 2014, to Restated Certificate of Incorporation
3.04 Certificate of Amendment, dated September 18, 2015, to Restated Certificate of Incorporation
3.05 Certificate of Amendment, dated May 18, 2016, to Restated Certificate of Incorporation
3.06 Certificate of Amendment, dated June 5, 2017, to Restated Certificate of Incorporation
3.07 Form of Certificate of Designation of Preferences, Rights and Limitations of Series A 17.38% Convertible Preferred Stock (found at Exhibit A-1, herein)
3.08 Form of Certificate of Designation of Preferences, Rights and Limitations of Series B 17.38% Convertible Preferred Stock (found at Exhibit A-2, herein)
3.09 Form of Certificate of Designation of Preferences, Rights and Limitations of Series C Convertible Preferred Stock (found at Exhibit A-3, herein)
3.10 Form of Certificate of Designation of Preferences, Rights and Limitations of Series D Convertible Preferred Stock (found at Exhibit E, herein)
3.11 Restated Bylaws
4.01 Specimen of Common Stock Certificate
4.02 Form of certificate representing the Series A 17.38% Convertible Preferred Stock (found at Exhibit D, herein)
4.03 Form of certificate representing the Series B 17.38% Convertible Preferred Stock (found at Exhibit D, herein)
4.04 Form of certificate representing the Series C Convertible Preferred Stock (found at Exhibit D, herein)
4.05 Form of certificate representing the Series D Convertible Preferred Stock
4.06 a Amended and Restated Letter Agreement re: Certain Registration Rights dated May 8, 2014 between registrant and the purchasers listed therein
4.07 Warrant to Purchase Stock, dated December 23, 2011, issued to ATEL Ventures, Inc.
4.08 a Side Letter, dated June 21, 2010, between registrant and Total Gas & Power USA, SAS
4.09 Agreement, dated February 23, 2012, among registrant, Maxwell (Mauritius) Pte Ltd, Naxyris SA, Biolding Investment S.A., and Sualk Capital Ltd.
4.10 Securities Purchase Agreement, dated July 24, 2015, between registrant and the Purchasers listed therein
4.11 c Warrant to Purchase Stock issued July 29, 2015 by registrant to Total Energies Nouvelles Activités USA
4.12 Exchange Agreement, dated July 26, 2015, between registrant and the investors listed therein

 

 

 

 121 

 

 

Exhibit
No.
Description
4.13 Letter Agreement dated as of July 29, 2015 among registrant and registrant’s security holders listed therein
4.14 Warrant to Purchase Stock issued July 29, 2015 by registrant to Total Energies Nouvelles Activités USA
4.15 Warrant to Purchase Stock issued July 29, 2015 by registrant to Maxwell (Mauritius) Pte Ltd
4.16 Warrant to Purchase Stock issued July 29, 2015 by registrant to Maxwell (Mauritius) Pte Ltd
4.17 Registration Rights Agreement, dated October 20, 2015, between registrant and registrant’s security holders listed therein
4.18 Note and Warrant Purchase Agreement, dated February 12, 2016, between registrant and the purchasers listed therein
4.19 d Warrant to Purchase Stock issued February 12, 2016 by registrant to Foris Ventures, LLC
4.20 Securities Purchase Agreement, dated April 8, 2016, between registrant and Bill & Melinda Gates Foundation
4.21 Letter Agreement re Charitable Purposes and Use of Funds, dated April 8, 2016, between registrant and the Bill & Melinda Gates Foundation
4.22 Warrant to Purchase Stock issued November 16, 2016 by registrant to Nenter & Co., Inc.
4.23 Purchase Money Promissory Note issued December 19, 2016 by registrant to Nikko Chemicals Co. Ltd.
4.24 Form of Securities Purchase Agreement, dated May 8, 2017, between registrant and the other parties thereto
4.25 Amendment No. 1, dated May 30, 2017 to Securities Purchase Agreement, dated May 8, 2017, between registrant and the other parties thereto
4.26 Form of Common Stock Purchase Warrant (Cash Warrant) issued May 11, 2017 by registrant to the purchasers thereof (found at Exhibit C-1, herein)
4.27 Form of Common Stock Purchase Warrant (Dilution Warrant) issued May 11, 2017 by registrant to the purchasers thereof (found at Exhibit C-2, herein)
4.28 Securities Purchase Agreement, dated May 31, 2017, between registrant and the investor named therein
4.29 Securities Purchase Agreement, dated August 2, 2017, between registrant and DSM International B.V.
4.30 Securities Purchase Agreement, dated August 2, 2017, between registrant and affiliates of Vivo Capital LLC
4.31 Form of Common Stock Purchase Warrant (Cash Warrant) issued August 7, 2017 by registrant to DSM International B.V. (found at Exhibit B-1, herein)
4.32 Form of Common Stock Purchase Warrant (Dilution Warrant) issued August 7, 2017 by registrant to DSM International B.V. (found at Exhibit B-2, herein)
4.33 Form of Stockholder Agreement, dated August 3, 2017, between registrant and affiliates of Vivo Capital LLC (found at Exhibit C, herein)
4.34 Common Stock Purchase Warrant (Cash Warrant), issued May 31, 2017, by registrant to the investor named therein
4.35 Common Stock Purchase Warrant (Dilution Warrant), issued May 31, 2017, by registrant to the investor named therein
4.36 a Stockholder Agreement, dated May 11, 2017, between registrant and DSM International B.V.
4.37 a Amended and Restated Stockholder Agreement, dated August 7, 2017, between registrant and DSM International B.V.
4.38 Promissory Note issued November 13, 2017 by registrant to Ginkgo Bioworks, Inc.

 

 

 

 122 

 

 

Exhibit
No.
Description
4.39 Note issued December 28, 2017 by registrant to DSM Finance BV
4.40 Warrant Exercise Agreement, dated August 17, 2018, between registrant and Foris Ventures, LLC
4.41 Warrant Exercise Agreement, dated August 17, 2018, between registrant and Vivo Capital Fund VIII, L.P.
4.42 Warrant Exercise Agreement, dated August 17, 2018, between registrant and Vivo Capital Surplus Fund VIII, L.P.
4.43 Common Stock Purchase Warrant issued August 17, 2018 by registrant to Foris Ventures, LLC
4.44 Common Stock Purchase Warrant issued August 17, 2018 by registrant to Vivo Capital Fund VIII, L.P.
4.45 Common Stock Purchase Warrant issued August 17, 2018 by registrant to Vivo Capital Surplus Fund VIII, L.P.
4.46 Common Stock Purchase Warrant issued August 20, 2018 by registrant to Vivo Capital Fund VIII, L.P.
4.47 Common Stock Purchase Warrant issued August 20, 2018 by registrant to Vivo Capital Surplus Fund VIII, L.P.
4.48 Securities Purchase Agreement, dated November 19, 2018, between registrant and DSM International B.V.
4.49 Securities Purchase Agreement, dated December 6, 2018, among registrant and the investors named therein
4.50 Form of Registration Rights Agreement, dated December 10, 2018, among registrant and the investors party thereto (found at Exhibit B, herein)  
4.51 Description of Capital Stock

10.01 Lease, dated August 22, 2007, between registrant and ES East Associates, LLC
10.02 First Amendment, dated March 10, 2008, to Lease, dated August 22, 2007, between registrant and ES East Associates, LLC
10.03 Second Amendment, dated April 25, 2008, to Lease, dated August 22, 2007, between registrant and ES East Associates, LLC
10.04 Third Amendment, dated July 31, 2008, to Lease, dated August 22, 2007, between registrant and ES East Associates, LLC
10.05 Fourth Amendment, dated November 14, 2009, to Lease, dated August 22, 2007, between registrant and ES East Associates, LLC
10.06 Fifth Amendment, dated October 15, 2010, to Lease, dated August 22, 2007, between registrant and ES East, LLC
10.07 Sixth Amendment, dated April 30, 2013, to Lease, dated August 22, 2007, between registrant and ES East, LLC
10.08 Lease dated April 25, 2008 between registrant and EmeryStation Triangle, LLC

10.09 Letter, dated April 25, 2008, amending Lease between registrant and EmeryStation Triangle, LLC
10.10 Second Amendment, dated February 5, 2010, to Lease, dated April 25, 2008, between registrant and EmeryStation Triangle, LLC
10.11 Third Amendment, dated May 1, 2013, to Lease, dated April 25, 2008, between registrant and EmeryStation Triangle, LLC
10.12 Pilot Plant Expansion Right Letter dated December 22, 2008 between registrant and EmeryStation Triangle, LLC
10.13 Lease Agreement, dated August 10, 2011, between Amyris Brasil Ltda. and Techno Park Empreendimentos e Administração Imobiliária Ltda.
10.14 First Amendment, dated July 31, 2015, to Lease Agreement, dated August 10, 2011, between Amyris Brasil Ltda. and Techno Park Empreendimentos e Administração Imobiliária Ltda.

 

 

 

 123 

 

 

Exhibit
No.
Description
10.15 Second Amendment, dated October 31, 2015, to Lease Agreement, dated August 10, 2011, between Amyris Brasil Ltda. and Techno Park Empreendimentos e Administração Imobiliária Ltda.
10.16 Third Amendment, dated March 30, 2016, to Lease Agreement, dated August 10, 2011, between Amyris Brasil Ltda. and Techno Park Empreendimentos e Administração Imobiliária Ltda.
10.17 Private Instrument of Non-Residential Real Estate Lease Agreement, dated March 31, 2008, between Lucio Tomasiello and Amyris Brasil S.A. (including Amendment No. 1, dated July 5, 2008, and Amendment No. 2, dated October 30, 2008)
10.18 ae Third Amendment, dated October 1, 2012, to the Private Instrument of Non Residential Real Estate Lease Agreement, dated March 31, 2008, between Lucio Tomasiello and Amyris Brasil Ltda.
10.19 ae Fourth Amendment, dated March 3, 2015, to the Private Instrument of Non-Residential Real Estate Lease Agreement, dated March 31, 2008, among Amyris Brasil Ltda., Lucius Tomasiello and Mauricio Tomasiello
10.20 e Fifth Amendment, dated September 22, 2015, to the Private Instrument of Non-Residential Real Estate Lease Agreement, dated March 31, 2008, among Amyris Brasil Ltda., Lucius Tomasiello and Mauricio Tomasiello
10.21 e Sixth Amendment, dated October 17, 2016, to the Private Instrument of Non-Residential Real Estate Lease Agreement, dated March 31, 2008, among Amyris Brasil Ltda., Lucius Tomasiello and Mauricio Tomasiello
10.22 Seventh Amendment, dated September 25, 2017, to the Private Instrument of Non-Residential Real Estate Lease Agreement, dated March 31, 2008, among Amyris Brasil Ltda., Lucius Tomasiello and Mauricio Tomasiello
10.23 e Lease Agreement, dated May 1, 2010, between São Martinho S.A. and SMA Indústria Química S.A.
10.24 e Amendment No. 2, dated August 31, 2015, to the Lease Agreement, dated May 1, 2010, between São Martinho S.A. and SMA Indústria Química S.A.
10.25 e Amendment No. 3, dated September 1, 2016, to the Lease Agreement, dated May 1, 2010, between São Martinho S.A. and SMA Indústria Química Ltda. (f.k.a. SMA Indústria Química S.A.)
10.26 e Amendment No. 4, dated December 26, 2017, to the Lease Agreement, dated May 1, 2010, between São Martinho S.A. and SMA Indústria Química Ltda. (f.k.a. SMA Indústria Química S.A.)
10.27 a Partnership Agreement, dated October 20, 2017, between registrant and Ginkgo Bioworks, Inc.
10.28 Credit Agreement, dated December 28, 2017, between registrant and DSM Finance BV
10.29 a Joint Venture Agreement, dated December 12, 2016, among registrant, Nikko Chemicals Co. Ltd., and Nippon Surfactant Industries Co., Ltd.
10.30 a First Amended and Restated LLC Operating Agreement of Aprinnova, LLC (f/k/a Neossance, LLC) dated December 6, 2016

10.31 Loan and Security Agreement, dated June 29, 2018, among the registrant, certain subsidiaries of the registrant and GACP Finance Co., LLC
10.32 Amendment No. 1, dated August 24, 2018, to Loan and Security Agreement, dated June 29, 2018, among registrant, certain of registrant’s subsidiaries and GACP Finance Co., LLC, as administrative agent and lender

 

 

 

 124 

 

 

Exhibit
No.
Description
10.33 Amendment No. 2, dated November 14, 2018, to Loan and Security Agreement, dated June 29, 2018, among registrant, certain of registrant’s subsidiaries and GACP Finance Co., LLC, as administrative agent and lender
10.34 Amendment No. 3, dated December 14, 2018, to Loan and Security Agreement, dated June 29, 2018, among registrant, certain of registrant’s subsidiaries and GACP Finance Co., LLC, as administrative agent and lender
10.35 b Supply Agreement, dated December 28, 2017, between registrant and DSM Produtos Nutricionais Brasil S.A.
10.36 b Amendment No. 1, dated November 19, 2018, to Supply Agreement, dated December 28, 2017, between registrant and DSM Nutritional Products AG, as assignee of DSM Produtos Nutricionais Brasil S.A.
10.37 Assignment Agreement, dated December 31, 2018, between registrant and Hangzhou Xinfu Science & Tech Co. Ltd

10.38 f Offer Letter dated September 27, 2006 between registrant and John Melo
10.39 f Amendment, dated December 18, 2008, to Offer Letter, dated September 27, 2006, between registrant and John Melo
10.40 f Performance Stock Option Award Agreement, dated May 29, 2018, between the registrant and John Melo
10.41 f Amendment #1, dated May 30, 2018, to Executive Severance Plan Participation Agreement, dated December 18, 2013, between the registrant and John Melo
10.42 f Offer Letter, dated November 23, 2016, between registrant and Kathleen Valiasek
10.43 f Amendment, dated March 6, 2017, to Offer Letter, dated November 23, 2016, between registrant and Kathleen Valiasek
10.44 f Offer Letter, dated June 5, 2017, between registrant and Nicole Kelsey
10.45 f Amendment, dated September 18, 2017, to Offer Letter, dated June 5, 2017, between registrant and Nicole Kelsey
10.46 f Offer Letter, dated October 5, 2017, between registrant and Eduardo Alvarez
10.47 f 2005 Stock Option/Stock Issuance Plan, as amended on July 19, 2011
10.48 f Form of Notice of Grant of Stock Option under registrant’s 2005 Stock Option/Stock Issuance Plan
10.49 f Form of Notice of Grant of Stock Option (non-Exempt) under registrant’s 2005 Stock Option/Stock Issuance Plan
10.50 f Form of Notice of Grant of Stock Option (non-US) under registrant’s 2005 Stock Option/Stock Issuance Plan
10.51 f Form of Stock Option Agreement under registrant’s 2005 Stock Option/Stock Issuance Plan
10.52 f Form of Stock Option Agreement (non-US) under registrant’s 2005 Stock Option/Stock Issuance Plan
10.53 f Form of Stock Purchase Agreement under registrant’s 2005 Stock Option/Stock Issuance Plan
10.54 f Form of Stock Purchase Agreement (non-US) under registrant’s 2005 Stock Option/Stock Issuance Plan
10.55 f 2010 Equity Incentive Plan, as amended on May 22, 2018, and forms of award agreements thereunder
10.56 f 2010 Employee Stock Purchase Plan, as amended on May 22, 2018, and form of subscription agreement thereunder
10.57 f Executive Severance Plan, effective November 6, 2013
10.58 f Compensation arrangements between registrant and its non-employee directors

 

 

 

 125 

 

 

Exhibit
No.
Description
10.59 f Compensation arrangements between registrant and its executive officers
10.60 f Registrant’s 2018 Cash Bonus Plan
10.61 f Form of Indemnity Agreement between registrant and its directors and executive officers
16.1 Letter of PricewaterhouseCoopers LLP dated June 15, 2017
21.01 List of subsidiaries
23.01 Consent of Macias Gini & O’Connell LLP, independent registered public accounting firm
23.02 Consent of BDO USA, LLP, independent registered public accounting firm
24.01 Power of Attorney
31.01 Certification of Chief Executive Officer pursuant to Securities Exchange Act Rules 13a-14(c) and 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002
31.02 Certification of Chief Financial Officer pursuant to Securities Exchange Act Rules 13a-14(c) and 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002
32.01 g Certification of Chief Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
32.02 g Certification of Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
101.INS XBRL Instance Document
101.SCH XBRL Taxonomy Extension Schema Document
101.CAL XBRL Taxonomy Extension Calculation Linkbase Document
101.DEF XBRL Taxonomy Extension Definition Linkbase Document
101.LAB XBRL Taxonomy Extension Label Linkbase Document
101.PRE XBRL Taxonomy Extension Presentation Linkbase Document

 

 

a Portions of this exhibit, which have been granted confidential treatment by the Securities and Exchange Commission, have been omitted.
b Portions of this exhibit have been omitted pursuant to Item 601(b)(10)(iv) of Regulation S-K promulgated under the Exchange Act.
c Registrant issued substantially identical warrants to the purchasers under that certain Securities Purchase Agreement entered into on July 24, 2015. Registrant has filed the warrant issued to Total Energies Nouvelles Activites USA and has included with such exhibit a schedule (Schedule A to Exhibit 4.11) identifying each of the warrants and setting forth the material details in which the other warrants differ from the filed warrant (i.e., the names of the purchasers, the certificate numbers and the respective numbers of shares underlying the warrants).
d Substantially identical warrants were issued to three separate investors.  Registrant has filed the warrant issued to Foris Ventures, LLC, which is substantially identical in all material respects to all of such warrants except as to the parties thereto, the issue date and the number of underlying shares.
e Translation to English from Portuguese in accordance with Rule 12b-12(d) of the regulations promulgated by the Securities and Exchange Commission under the Exchange Act.
f Indicates management contract or compensatory plan or arrangement.
g This certification shall not be deemed “filed” for purposes of Section 18 of the Exchange Act or otherwise subject to the liability of that section, nor shall it be deemed incorporated by reference into any filing under the Securities Act or the Exchange Act.

 

 

 

126

 

EX-23.01 2 exh_2301.htm EXHIBIT 23.01

EXHIBIT 23.01

 

 

 

Consent of Independent Registered Public Accounting Firm

 

 

To the Board of Directors and Stockholders of Amyris, Inc.

 

We consent to the incorporation by reference in the Registration Statements (Nos. 333-169715, 333-172514, 333-180006, 333-187598, 333-188711, 333-195259, 333-203213, 333-210569, 333-217345, 333-224316 and 333-225848) on Form S-8 of Amyris, Inc and Subsidiaries (the Company) of our reports dated October 1, 2019, relating to the Company's consolidated financial statements as of and for the year ended December 31, 2018, and the effectiveness of internal control over financial reporting as of December 31, 2018, which reports appear in this December 31, 2018 Annual Report on Form 10-K/A of the Company.

 

Our report on the effectiveness of internal control over financial reporting expresses an adverse opinion on the effectiveness of the Company’s internal control over financial reporting as of December 31, 2018.

 

Our report on the consolidated financial statements refers to a change in accounting for revenue recognition in 2018 due to the adoption of Topic 606, Revenue from Contracts with Customers, and contains an emphasis paragraph that states that the Company has suffered recurring losses from operations and has current debt service requirements that raise substantial doubt about its ability to continue as a going concern. The consolidated financial statements do not include any adjustments that might result from the outcome of this uncertainty.

 

 

/s/ Macias Gini & O'Connell LLP

 

San Francisco, California

October 4, 2019

 

 

 

 

EX-23.02 3 exh_2302.htm EXHIBIT 23.02

EXHIBIT 23.02

 

 

Consent of Independent Registered Public Accounting Firm

 

Amyris, Inc.

Emeryville, California

We hereby consent to the incorporation by reference in the Registration Statements on Form S-8 (Nos. 333-169715, 333-172514, 333-180006, 333-187598, 333-188711, 333-195259, 333-203213, 333-210569, 333-217345, 333-224316 and 333-225848) of Amyris, Inc. of our report dated October 1, 2019, relating to the consolidated financial statements which appears in this Form 10-K/A. Our report contains an explanatory paragraph regarding the Company’s ability to continue as a going concern.

 

 

/s/ BDO USA, LLP

San Jose, California

 

October 4, 2019

 

 

 

 

 

 

EX-31.01 4 exh_3101.htm EXHIBIT 31.01

EXHIBIT 31.01

 

CERTIFICATION OF PERIODIC REPORT UNDER SECTION 302 OF

THE SARBANES-OXLEY ACT OF 2002

 

I, John G. Melo, certify that:

 

1.I have reviewed this annual report on Form 10-K of Amyris, Inc., as amended;

 

2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

 

3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

 

4.The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

 

a)Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
b)Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
c)Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
d)Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

 

5.The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):
a)All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
b)Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

 

 

    /s/ John G. Melo
    John G. Melo
    President and Chief Executive Officer
    October 4, 2019

 

 

 

EX-31.02 5 exh_3102.htm EXHIBIT 31.02

EXHIBIT 31.02

 

CERTIFICATION OF PERIODIC REPORT UNDER SECTION 302 OF

THE SARBANES-OXLEY ACT OF 2002

 

I, Jonathan Wolter, certify that:

 

1.I have reviewed this annual report on Form 10-K of Amyris, Inc., as amended;

 

2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

 

3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

 

4.The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

 

a)Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
b)Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
c)Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
d)Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

 

5.The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):
a)All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
b)Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

 

 

    /s/ Jonathan Wolter
    Jonathan Wolter
    Interim Chief Financial Officer
    October 4, 2019

 

 

 

EX-32.01 6 exh_3201.htm EXHIBIT 32.01

EXHIBIT 32.01

 

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350

AS ADOPTED PURSUANT TO SECTION 906

OF THE SARBANES-OXLEY ACT OF 2002

 

I, John G. Melo, President and Chief Executive Officer of Amyris, Inc. (Company), do hereby certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to the best of my knowledge:

 

the Annual Report on Form 10-K of the Company for the year ended December 31, 2018, as amended (Report) fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

 

the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company for the periods presented therein.

 

 

    /s/ John G. Melo
    John G. Melo
    President and Chief Executive Officer
    October 4, 2019

 

 

 

 

 

 

 

 

 

EX-32.02 7 exh_3202.htm EXHIBIT 32.02

EXHIBIT 32.02

 

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350

AS ADOPTED PURSUANT TO SECTION 906

OF THE SARBANES-OXLEY ACT OF 2002

 

I, Jonathan Wolter, Interim Chief Financial Officer of Amyris, Inc. (Company), do hereby certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to the best of my knowledge:

 

the Annual Report on Form 10-K of the Company for the year ended December 31, 2018, as amended (Report) fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

 

the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company for the periods presented therein.

 

 

    /s/ Jonathan Wolter
    Jonathan Wolter
    Interim Chief Financial Officer
    October 4, 2019

 

 

 

 

 

 

 

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font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;">Going Concern</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company has incurred significant operating losses since its inception and expects to continue to incur losses and negative cash flows from operations for at least the next <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12</div> months following the issuance of the financial statements. As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> the Company had negative working capital of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$119.5</div> million and an accumulated deficit of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.5</div> billion.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> the Company's debt (including related party debt), net of deferred discount and issuance costs of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$17.1</div> million and a change in fair value of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.1</div> million, totaled <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$209.7</div> million, of which <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$147.7</div> million is classified as current. The Company's debt agreements contain various covenants, including certain restrictions on the Company's business that could cause the Company to be at risk of defaults, such as restrictions on additional indebtedness, material adverse effect and cross default clauses. A failure to comply with the covenants and other provisions of the Company&#x2019;s debt instruments, including any failure to make a payment when required, would generally result in events of default under such instruments, which could permit acceleration a substantial portion of such indebtedness. If such indebtedness is accelerated, it would generally also constitute an event of default under the Company&#x2019;s other outstanding indebtedness, permitting acceleration of a substantial portion of such other outstanding indebtedness. At <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018, </div>the Company failed to meet certain covenants in connection with the GACP Term Loan Facility (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> &#x201c;Debt&#x201d;), including those associated with minimum revenue and minimum liquidity requirements. In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 2019, (</div>i) GACP provided a waiver to the Company for breaches of all covenant violations under the GACP loan and security agreement (LSA) occurring prior to, as of and after <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018 </div>through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 8, 2019, </div>and (ii) GACP sold and assigned the loans under the LSA and all documents and assets related thereto to Foris Ventures, LLC (Foris). Subsequently, Foris provided a waiver to the Company for breaches of certain covenants under the LSA through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 30, 2020 </div>and amended the financial covenants under the LSA to provide more favorable compliance terms and conditions. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> "Subsequent Events" for additional information.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Cash and cash equivalents of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$45.4</div> million as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> are <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> sufficient to fund expected future negative cash flows from operations and cash debt service obligations through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">30,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2020.</div> These factors raise substantial doubt about the Company&#x2019;s ability to continue as a going concern within <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> year after the date that these financial statements are issued. The consolidated financial statements do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> include any adjustments that might result from the outcome of this uncertainty. The Company's ability to continue as a going concern will depend, in large part, on its ability to achieve positive cash flows from operations during the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12</div> months from the date of this filing, and refinance or extend other existing debt maturities occurring later in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> all of which are uncertain and outside the control of the Company. Further, the Company's operating plan for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> contemplates a significant reduction in its net operating cash outflows as compared to the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> resulting from (i) revenue growth from sales of existing and new products with positive gross margins, (ii) reduced production costs as a result of manufacturing and technical developments, and (iii) an increase in cash inflows from collaborations and grants. If the Company is unable to complete these actions, it expects to be unable to meet its operating cash flow needs and its obligations under its existing debt facilities. This could result in an acceleration of its obligation to repay all amounts outstanding under those facilities, and the Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be forced to obtain additional equity or debt financing, which <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> occur timely or on reasonable terms, if at all, and/or liquidate its assets. In such a scenario, the value received for assets in liquidation or dissolution could be significantly lower than the value reflected in these financial statements. The Company has in the past, including in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2019, </div>had certain of its debt instruments accelerated for failure to make a payment when due. While we have been able to cure these defaults to date to avoid additional cross-acceleration, we <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> be able to cure such a default promptly in the future.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <!-- Field: Page; Sequence: 13 --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 16, 2019, </div>the Company failed to pay an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$63.6</div> million of outstanding principal and accrued interest on the Second Exchange Note when due. The failure resulted in an event of default under the Second Exchange Note and also triggered cross-defaults under other debt instruments of the Company which permitted the holders of such indebtedness to accelerate the amounts owing under such instruments. The Company subsequently received waivers from substantially all holders of such other debt instruments to waive the right to accelerate. As a result, the indebtedness with respect to which the Company has obtained such waivers continues to be classified as long-term on the Company&#x2019;s balance sheet.&nbsp; The indebtedness reflected by the Second Exchange Note continues to be classified as a current liability on the Company&#x2019;s balance sheet. In addition, as a result of the payment default, the conversion price of the Second Exchange Note is subject to adjustment in accordance with the terms of the Second Exchange Note.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> currently have sufficient funds to repay the amounts outstanding under the Second Exchange Note. To date, negotiations with the holder of the Second Exchange Note have <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> been successful, and there can be <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> assurance that a favorable outcome for the Company will be reached. The Company has executed a term sheet with an existing investor for a term loan, the proceeds of which would be used to repay a portion of the Second Exchange Note. However, there can be <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> assurance that the Company will be able to obtain such financing on its expected timeline, or on acceptable terms, if at all. Even if the Company does obtain such financing, it will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> have sufficient funds to repay the Second Exchange Note in full without obtaining additional financing, which the Company is attempting to source. The consolidated financial statements do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> include any adjustments that might result from the outcome of this uncertainty.</div></div></div></div></div></div></div></div></div></div></div></div> 0.025 147677000 56943000 62020000 106761000 17424000 11897000 1521000 10376000 35000000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font-size: 10pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6.</div> Mezzanine Equity</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">Mezzanine equity at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div> is comprised of proceeds from common shares sold on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 10, 2016 </div>to the Bill&nbsp;&amp; Melinda Gates Foundation (the Gates Foundation). On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 8, 2016, </div>the Company entered into a Securities Purchase Agreement with the Gates Foundation, pursuant to which the Company agreed to sell and issue <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">292,398</div> shares of its common stock to the Gates Foundation in a private placement at a purchase price per share of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$17.10,</div> the average of the daily closing price per share of the Company&#x2019;s common stock on the Nasdaq Stock Market for the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">twenty</div> consecutive trading days ending on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016,</div> for aggregate proceeds to the Company of approximately <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.0</div> million (the Gates Foundation Investment). The Securities Purchase Agreement includes customary representations, warranties and covenants of the parties.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">In connection with the entry into the Securities Purchase Agreement, on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016,</div> the Company and the Gates Foundation entered into a Charitable Purposes Letter Agreement, pursuant to which the Company agreed to expend an aggregate amount <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> less than the amount of the Gates Foundation Investment to develop a yeast strain that produces artemisinic acid and/or amorphadiene at a low cost and to supply such artemisinic acid and amorphadiene to companies qualified to convert artemisinic acid and amorphadiene to artemisinin for inclusion in artemisinin combination therapies used to treat malaria commencing in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017.</div> The Company is currently conducting the project. If the Company defaults in its obligation to use the proceeds from the Gates Foundation Investment as set forth above or defaults under certain other commitments in the Charitable Purposes Letter Agreement, the Gates Foundation will have the right to request that the Company redeem, or facilitate the purchase by a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">third</div> party of, the Gates Foundation Investment shares then held by the Gates Foundation at a price per share equal to the greater of (i) the closing price of the Company&#x2019;s common stock on the trading day prior to the redemption or purchase, as applicable, or (ii) an amount equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$17.10</div> plus a compounded annual return of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10%.</div> As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> the Company's remaining research and development obligation under this arrangement was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.7</div> million.</div></div> 0.045 6764000 762000 495000 467000 467000 -13413000 -13413000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Noncontrolling Interest</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Noncontrolling interests represent the portion of net income (loss), net assets and comprehensive income (loss) that is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> allocable to the Company, in situations where the Company consolidates its equity investment in a joint venture for which there are other owners. The amount of noncontrolling interest is comprised of the amount of such interests at the date of the Company's original acquisition of an equity interest in a joint venture, plus the other shareholders' share of changes in equity since the date the Company made an investment in the joint venture.</div></div></div></div></div></div></div></div></div></div></div></div> 16954000 16954000 456200000 115500000 800000 800000 12700000 2155000 6185000 6444000 800000 3113000 3113000 12472000 4412000 4412000 1800000 0 3250000 5.08 5.08 5100000 0.05 2100000 1800000 1738 5800000 0.0999 17.25 4.26 15 6.30 6.30 4.26 40204 22140 55700 12958 11530000 11530000 1000 1000 1000 6050000 777000 98246000 101124000 -2878000 200000 100000 72725000 72725000 50000000 37700000 3250000 2661000 -2661000 8046000 8046000 9000000 631000 87000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Recoverable Taxes from Brazilian Government Entities</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Recoverable taxes from Brazilian government entities represent value-added taxes paid on purchases in Brazil, which are reclaimable from the Brazilian tax authorities, net of reserves for amounts estimated <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> to be recoverable.</div></div></div></div></div></div></div></div></div></div></div></div> 3005000 1445000 1445000 700000 25000000 15000000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">Years Ended December 31, <br /> <div style="display: inline; text-decoration: underline;">(In thousands)</div></div></div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017 (As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Renewable Products</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Licenses and Royalties</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Grants and Collaborations</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">TOTAL</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Renewable Products</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Licenses and Royalties</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Grants and Collaborations</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">TOTAL</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Revenue from significant revenue agreements with:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 36%; text-align: left">DSM (related party)</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 5%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 5%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,958</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 5%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,735</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 5%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,711</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 5%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 5%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,972</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 5%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,679</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 5%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">59,651</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Firmenich</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,727</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,700</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,717</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,144</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,621</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,199</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,803</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,623</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>DARPA</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,436</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,436</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,333</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,333</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Givaudan</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,078</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,358</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,436</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,950</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,950</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Nenter</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,057</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,633</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">14,690</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Ginkgo</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(13,113</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(13,113</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Subtotal revenue from significant revenue agreements</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,823</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,658</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,246</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">38,727</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,628</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">48,691</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,815</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">98,134</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Revenue from all other customers</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,775</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(898</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,877</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,742</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,783</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29,537</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Total revenue from all customers</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">33,598</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,658</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">22,348</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">63,604</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,370</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">48,703</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">36,598</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">127,671</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> 21400000 4500000 0.1 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;">Sale of Subsidiary and Entry into Commercial Agreements</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 28, 2017, </div>the Company completed the sale of all of the capital stock of its subsidiary Amyris Brasil, a wholly-owned subsidiary, to DSM Produtos Nutricionais Brasil S.A (DSM), a related party. Amyris Brasil owned and operated the Company&#x2019;s production facility in Brotas, Brazil. The transaction resulted in a pretax gain of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.7</div> million from continuing operations in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> which was further adjusted by a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.8</div> million loss in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> related to the final working capital adjustments between the Company and DSM. The transaction did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> result in presenting Amyris Brasil as a discontinued operation in the consolidated financial statements, as the sale did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> represent a strategic shift that will have a major effect on the Company&#x2019;s operations and financial results due to the Company&#x2019;s continuing commercial presence and reinvestment in a new production facility under construction in Brazil and its continuing Brazilian operation through Amyris Biotecnologia do Brasil Ltda. (formerly SMA Ind&uacute;stria Qu&iacute;mica Ltda.). The Company and DSM also entered into a series of commercial agreements and a credit agreement concurrently with the sale of Amyris Brasil. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> &#x201c;Revenue Recognition&#x201d;, Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,</div> &#x201c;Related Party Transactions&#x201d;, Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,</div> &#x201c;Divestiture&#x201d; and Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> &#x201c;Subsequent Events&#x201d; for further information.</div></div></div></div></div></div></div></div></div></div></div></div> 0.7 0.3 0.5 0.5 <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold">December 31,<br /> (In thousands)</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="text-align: center"><div style="display: inline; font-weight: bold;">(As Restated, Note 2)</div></td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Payroll and related expenses</td> <td>&nbsp;</td> <td style="text-align: right">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,220</div></td> <td style="text-align: right">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: right">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,238</div></td> <td style="text-align: right">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 66%; text-align: left">Contract termination fees</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,092</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Accrued interest</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,853</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,213</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Asset retirement obligation<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(1)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,063</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,587</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Ginkgo partnership payments obligation</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,155</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Tax-related liabilities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,139</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,837</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Professional services</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,173</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,694</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Other</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,284</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,633</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Total accrued and other current liabilities</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28,979</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29,202</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; text-align: left"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">Years Ending December&nbsp;31 </div></div><br /> <div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; text-decoration: underline;">(In thousands)</div></div></div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Capital <br /> Leases</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Operating <br /> Leases</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total Lease <br /> Obligations</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 55%; text-align: left">2019</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">513</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,416</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,929</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2020</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">198</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,932</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,130</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">2021</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,226</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,227</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2022</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,399</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,399</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">2023</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,034</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,034</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Thereafter</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Total future minimum payments</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">712</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">36,007</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">36,719</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Less: amount representing interest</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(33</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Present value of minimum lease payments</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">679</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Less: current portion</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(484</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Long-term portion</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">195</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">December 31, </div></div><br /> <div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; text-decoration: underline;">(In thousands)</div></div></div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 62%">DSM</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 16%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,071</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 16%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,823</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Novvi</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">188</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,607</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Total</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">90</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">238</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Related party accounts receivable, net</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,349</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">14,668</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">December 31, <br /> <div style="display: inline; text-decoration: underline;">(In thousands)</div></div></div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 68%">Assets</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,904</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,635</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Liabilities</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,364</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,187</div></td> <td style="text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">December 31, </div></div><br /> <div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; text-decoration: underline;">(in thousands)</div></div></div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="11" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="11" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td style="white-space: nowrap">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Principal</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Unamortized <br /> Debt <br /> (Discount) <br /> Premium</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Net</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Principal</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Unamortized <br /> Debt <br /> (Discount) <br /> Premium</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Net</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="white-space: nowrap">Total</td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 40%; text-align: left; text-indent: 10pt">2014 Rule 144A convertible notes</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,705</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(422</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">)</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,283</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,705</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,538</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">)</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,167</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">August 2013 financing convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">21,711</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">897</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">22,608</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">R&amp;D note</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,700</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(18</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,682</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,705</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(422</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,283</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">35,116</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(659</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">34,457</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>DSM</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">DSM note</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,311</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,689</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(8,039</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,961</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Other DSM loan</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">393</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">393</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,311</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,689</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,393</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(8,039</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">17,354</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Biolding</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">February 2016 private placement</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Foris</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">2014 Rule 144A convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(181</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,819</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(660</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,340</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Temasek</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">2014 Rule 144A convertible notes</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,000</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(435</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,565</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,000</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,591</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,409</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">49,705</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(7,349</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">)</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,356</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">77,509</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(10,949</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">)</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">66,560</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold">Years Ended December 31,<br /> <div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017 (As restated, Note 2)</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Renewable Products</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Licenses and Royalties</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Grants and Collaborations</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">TOTAL</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Renewable Products</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Licenses and Royalties</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Grants and Collaborations</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">TOTAL</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Revenue from related parties:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 28%">DSM</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,958</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,735</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,711</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,972</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,679</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">59,651</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Total</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">342</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">342</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(200</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(200</div></td> <td style="text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Novvi</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,491</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,491</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Subtotal revenue from related parties</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">360</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,958</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,735</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,053</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,291</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,972</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,679</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60,942</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left"><div style="display: inline; font-size: 10pt">Revenue from all other customers<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(1)</div></div></td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">33,238</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,700</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">17,613</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">52,551</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">41,079</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(9,269</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">34,919</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">66,729</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Total revenue from all customers</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">33,598</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,658</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">22,348</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">63,604</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,370</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">48,703</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">36,598</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">127,671</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> 5000000 25000000 25000000 108670000 4953264 5.50 P1Y219D 1 1 1.1 1.1 0.1 0.1 P10Y P10Y 0.01 3652935 1200000 1643991 12600000 1852585 6329488 0 4678 0 25643 11749770 7288683 1889986 20928439 3148097 20891038 6050000 6050000 1800000 3436000 3436000 10708000 10708000 24970000 28702000 28702000 10500000 22600000 10505000 10505000 22632000 22632000 2500000 33300000 33304000 6764000 24395000 0.225 0 1800000 P5Y 2900000 2145000 14700000 42939000 305781000 0.1999 0.1999 0.05 0.0999 0.1 119500000 2100000 This Amendment No. 1 on Form 10-K/A (this &#x201c;Amendment&#x201d;) amends the Annual Report on Form 10-K of Amyris, Inc. (the &#x201c;Company&#x201d;) for the fiscal year ended December 31, 2018 (the &#x201c;Form 10-K&#x201d;), as filed with the Securities and Exchange Commission (the &#x201c;SEC&#x201d;) on October 1, 2019 (the &#x201c;Original Filing Date&#x201d;). This Amendment is being filed solely (i) for the purpose of furnishing Exhibit 101 (Interactive Data Files) to the Form 10-K, which was not included in the original filing of the Form 10-K with the SEC on the Original Filing Date, (ii) to correct administrative errors in the content of (A) the Report of Independent Registered Public Accounting Firm of BDO USA, LLP (the &#x201c;BDO Report&#x201d;), the Company&#x2019;s independent registered public accounting firm for the fiscal year ended December 31, 2017, contained in Part II, Item 8 of the Form 10-K and (B) the Reports of Independent Registered Public Accounting Firm of Macias Gini &amp; O&#x2019;Connell LLP (the &#x201c;MGO Reports&#x201d;), the Company&#x2019;s independent registered public accounting firm for the fiscal year ended December 31, 2018, contained in Part II, Item 8 and Part II, Item 9A of the Form 10-K, respectively and (iii) to correct certain other immaterial errors in Part II, Item 8 of the Form 10-K as set forth below. The BDO Report and MGO Reports in the Form 10-K incorrectly contained certain references to September 30, 2019, when the correct date was October 1, 2019. Accordingly, such reports have been updated to refer to the correct date. In addition, (i) certain references to &#x201c;Contract assets&#x201d; in the financial statement tables and related disclosure in Part II, Item 8 of the Form 10-K have been amended to refer to &#x201c;Accounts receivable, unbilled &#x2013; related party&#x201d;, (ii) a line item for &#x201c;Accounts receivable, unbilled, noncurrent - related party&#x201d; has been added to the &#x201c;Contract Balances&#x201d; table in Note 10, &#x201c;Revenue Recognition&#x201d; in Part II, Item 8 of this Amendment, (iii) the amount of federal NOL and state NOL carryovers written off by the Company as a result of events occurring during the year ended December 31, 2017, disclosed in Note 14, &#x201c;Income Taxes&#x201d; in Part II, Item 8 of the Form 10-K, has been corrected, (iv) certain legend references and explanations in the tables in Note 2, &#x201c;Restatement of 2017 Consolidated Financial Statements&#x201d; and the &#x201c;2017 and 2018 Quarterly Data &#x2013; Restated Condensed Consolidated Financial Statements&#x201d; section immediately after Note 16, &#x201c;Subsequent Events&#x201d; in Part II, Item 8 of the Form 10-K have been updated by deleting unused explanations, expanding or conforming certain explanations and adding certain explanations that were inadvertently excluded from such tables and (v) certain typographical errors in the financial statement tables and related disclosure in Part II, Item 8 of the Form 10-K have been corrected to conform to the correct disclosure provided elsewhere in Part II, Item 8 of the Form 10-K. No other changes have been made to the Form 10-K. This Amendment speaks as of the Original Filing Date and does not reflect events that may have occurred subsequent to the Original Filing Date, and, except as expressly set forth herein, does not modify or update in any way the disclosures made in the Form 10-K. Pursuant to Rule 12b-15 promulgated under the Securities Exchange Act of 1934, this Amendment sets forth the complete text of Part II, Item 8 and Part II, Item 9A of the Form 10-K as amended hereby. Part IV, Item 15 of this Amendment reflects (i) new consents of BDO USA, LLP and Macias Gini &amp; O&#x2019;Connell LLP, (ii) Exhibit 101 (Interactive Data Files) and (iii) new certifications pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 and Section 906 of the Sarbanes-Oxley Act of 2002, each of which is filed or furnished herewith, as applicable. true --12-31 FY 2018 2018-12-31 10-K/A 0001365916 103400207 Yes false Accelerated Filer 226500000 AMYRIS, INC. false true No No Common Stock amrs <div style="display: inline; font-family: times new roman; font-size: 10pt"><div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 13.5pt; text-indent: -13.5pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2.</div> Restatement of Consolidated Financial Statements</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-style: italic;">Restatement Background</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Subsequent to the issuance of the Company's unaudited condensed consolidated financial statements as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 30, 2018 </div>and as previously announced on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 5, 2019 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 14, 2019, </div>the Audit Committee (the Audit Committee) of the Board of Directors of the Company (the Board) and the Board, respectively, concluded that the Company will restate its interim condensed consolidated financial statements for the quarterly and year-to-date periods ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 31, 2018, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 30, 2018 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 30, 2018 (</div>collectively, the Restated <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> Non-Reliance Periods) and its audited consolidated financial statements for the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017 (</div>the Restated <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div> Non-Reliance Consolidated Financial Statements).</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-style: italic;">Restated <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div> Non-Reliance Consolidated Financial Statements</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">During the course of the re-audit of the Restated <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div> Financial Statements, in addition to incorrectly accounting for certain payment obligations under the Ginkgo Partnership Agreement as previously disclosed, the Company identified other accounting and financial reporting errors related to (i) the recognition of certain deemed dividends to preferred stock holders, (ii) incorrect accounting treatment for the derecognition of certain debt and derivative liability instruments, (iii) errors in computing tax expense, (iv) incorrect revenue recognition for certain non-cash consideration received under a collaboration agreement, (v) the timing of certain revenue recognition between quarters within <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> (vi) computation of earnings (loss) per share, (vii) correction of errors in cash flow statements for non-cash adjustments, and (viii) computation of loss on extinguishment of certain debt instruments.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The error corrections for the year to date audited <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div> consolidated financial statements have been reflected throughout these consolidated financial statements and accompanying notes. Also, the tables below show the impact of each adjustment by the individual financial statement line item caption and provide a brief description of the adjustment.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;"></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;">&nbsp;</div></div> </div> <!-- Field: Page; Sequence: 28; Value: 1 --> <div><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;"></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><div style="display: inline; font-weight: bold;">Consolidated Balance Sheet</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The following table presents the Company's consolidated balance sheet at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017 </div>as previously reported, restatement adjustments and as restated (in thousands):</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></div> <div> <table style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;" cellspacing="0" cellpadding="0"> <tr style="vertical-align: bottom"> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="12" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">December 31, 2017</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; font-weight: bold">&nbsp;</td> </tr> <tr style="vertical-align: bottom"> <td style="font-size: 10pt; padding-bottom: 1pt">(In thousands)</td> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="2" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">As Previously Reported</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; font-weight: bold">&nbsp;</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="2" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Corrections</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; font-weight: bold">&nbsp;</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; font-weight: bold; text-align: center">Ref.</td> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="2" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">As Restated</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; font-weight: bold">&nbsp;</td> </tr> <tr style="vertical-align: bottom"> <td style="font-size: 10pt; font-weight: bold">Assets</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="2" style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="2" style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="2" style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Current assets:</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 57%; font-size: 10pt; text-align: left; padding-left: 10pt">Cash and cash equivalents</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 9%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,059</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 9%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 6%; font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 9%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,059</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Restricted cash</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,994</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,994</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Accounts receivable, net</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,281</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(5,328</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">a</div></div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,953</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Accounts receivable - related party, net</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,340</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(4,573</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">a</div></div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,767</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Accounts receivable, unbilled - related party</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,901 </div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,901</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; padding-left: 10pt">Inventories</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,408</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,408</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt; padding-left: 10pt">Prepaid expenses and other current assets</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,525</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(606</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="padding-bottom: 1pt; font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">b</div></div></td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,919</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-left: 20pt">Total current assets</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">104,607</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(606</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">104,001</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Property, plant and equipment, net</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,892</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,892</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Accounts receivable, unbilled, noncurrent &#x2013; related party</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,940</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,940</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Restricted cash, noncurrent</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">959</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">959</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Recoverable taxes from Brazilian government entities</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,445</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,445</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt">Other assets</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">22,640</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(10,081</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="padding-bottom: 1pt; font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">c</div></div></td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,559</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-bottom: 2.5pt; padding-left: 20pt">Total assets</td> <td style="font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">151,483</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(10,687</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="padding-bottom: 2.5pt; font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">140,796</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; font-weight: bold; text-align: left">Liabilities, Mezzanine Equity and Stockholders' Deficit</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Current liabilities:</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Accounts payable</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15,921</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(406</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">d</div></div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15,515</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Accrued and other current liabilities</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29,402</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(200</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">e</div></div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29,202</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Contract liabilities</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,880</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(572</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">f</div></div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,308</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Debt, current portion</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">36,924</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">36,924</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt; padding-left: 10pt">Related party debt, current portion</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">20,019</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="padding-bottom: 1pt; font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">20,019</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-left: 20pt">Total current liabilities</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">107,146</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,178</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">105,968</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Long-term debt, net of current portion</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">61,893</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,673</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">g</div></div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60,220</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Related party debt, net of current portion</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">46,541</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">46,541</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Derivative liabilities</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">119,978</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,481</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">h</div></div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">116,497</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt">Other noncurrent liabilities</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,632</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,026</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="padding-bottom: 1pt; font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">i</div></div></td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,658</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt; padding-left: 20pt">Total liabilities</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">346,190</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,694</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="padding-bottom: 1pt; font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">352,884</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Commitments and contingencies</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Mezzanine equity:</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Contingently redeemable common stock</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,000</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,000</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Stockholders&#x2019; deficit:</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Preferred stock</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; padding-left: 10pt">Common stock - $0.0001 par value</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Additional paid-in capital</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,048,274</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">66,272</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">j</div></div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,114,546</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Accumulated other comprehensive loss</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(42,156</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(42,156</div></td> <td style="font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt; padding-left: 10pt">Accumulated deficit</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,206,767</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(83,653</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="padding-bottom: 1pt; font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">k</div></div></td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,290,420</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Total Amyris, Inc. stockholders&#x2019; deficit</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(200,644</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(17,381</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(218,025</div></td> <td style="font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt">Noncontrolling interest</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">937</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="padding-bottom: 1pt; font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">937</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt">Total stockholders' deficit</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(199,707</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(17,381</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="padding-bottom: 1pt; font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(217,088</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-bottom: 2.5pt">Total liabilities, mezzanine equity and stockholders' deficit</td> <td style="font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">151,483</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(10,687</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="padding-bottom: 2.5pt; font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">140,796</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><div style="display: inline; text-decoration: underline;">Restatement adjustments:</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">a. Reclassification of related party accounts receivable to a separate line on the balance sheet.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">b. Write-off of unrecoverable receivable in connection with facilities subleased to a related party.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">c. Correction of error in recording amounts payable under Ginkgo Partnership Agreement as prepaid royalties instead of reduction in revenue.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">d. Adjustment to uninvoiced receipts liability.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">e. Adjustment to accrued liability.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">f. Revision to accounting for equity received in satisfaction of a customer receivable.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">g. Adjustment to issuance-date fair value of a debt instrument.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">h. Make-whole derivative liabilities adjustment.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">i. Accrual of the Ginkgo Partnership Payments obligation, net of reduction to deferred revenue liability.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">j. Correction to the accounting for a make-whole equity instrument in connection with <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>equity offering.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">k. Sum of adjustments to net loss for the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017 </div>as result of corrections.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;">&nbsp;</div></div> </div> <!-- Field: Page; Sequence: 29; Value: 1 --> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <div style=" font-size: 10pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;">Consolidated Statement of Operations</div></div> <div style=" font-size: 10pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">The following table presents the Company's consolidated statements of operations for the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017 </div>as previously reported, restatement adjustments and as restated (in thousands, except per share amounts):</div> <div style=" font-size: 10pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; margin: 0pt 0"></div> <div> <table style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;" cellspacing="0" cellpadding="0"> <tr style="vertical-align: bottom"> <td style="text-align: left; vertical-align: top"></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="17" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Year Ended<br /> December 31, 2017</td> </tr> <tr style="vertical-align: bottom"> <td style="font-weight: bold">(In thousands, except shares and per share amounts)</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">As Previously Reported</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">Reclassifications<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(1)</div></div></div></td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Corrections</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">Ref</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">As Restated</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 46%; text-align: left; text-indent: -20pt; padding-left: 20pt">Renewable products</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">45,781</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,411</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">)</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 5%; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,370</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Licenses and royalties</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,703</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,774</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(15,774</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">ab</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">48,703</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt; text-indent: -20pt; padding-left: 20pt">Grants and collaborations</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">39,960</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,363</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"></td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">36,598</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt; text-indent: -20pt; padding-left: 30pt">Total revenue</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">143,444</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(15,773</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">127,671</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Cost and operating expenses</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: -20pt; padding-left: 30pt">Cost of products sold</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">62,713</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(406</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">ad</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">62,307</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 30pt">Research and development</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,027</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(72</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">607</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">ae</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,562</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt; text-indent: -20pt; padding-left: 30pt">Sales, general and administrative</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">63,219</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">72</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">562</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">af</div></div></td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">63,853</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt; text-indent: -20pt; padding-left: 40pt">Total cost and operating expenses</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">182,959</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">763</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">183,722</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt; text-indent: -20pt; padding-left: 20pt">Loss from operations</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(39,515</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(16,536</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(56,051</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Other income (expense)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: -20pt; padding-left: 30pt">(Loss) gain on divestiture</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,732</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,732</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 30pt">Interest expense</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(34,033</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,048</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">ah</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(37,081</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: -20pt; padding-left: 30pt">(Loss) gain from change in fair value of derivative instruments</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,742</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(47,110</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">ai</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(48,852</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 30pt">Loss upon extinguishment of debt</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,521</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(10,376</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">ak</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(11,897</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt; text-indent: -20pt; padding-left: 30pt">Other income (expense), net</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(955</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(956</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt; text-indent: -20pt; padding-left: 40pt">Total other expense, net</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(32,519</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(60,535</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(93,054</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Loss before income taxes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(72,034</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(77,071</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(149,105</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt; text-indent: -20pt; padding-left: 20pt">Provision for income taxes</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(295</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,582</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">am</div></div></td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,877</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Net loss attributable to Amyris, Inc.</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(72,329</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(83,653</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(155,982</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Less deemed dividend on capital distribution to related parties</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(8,648</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,648</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">an</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Less deemed dividend related to beneficial conversion feature on Series A preferred stock</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(562</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(562</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Less deemed dividend related to beneficial conversion feature on Series B preferred stock</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(634</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(634</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Less deemed dividend related to beneficial conversion feature on Series D preferred stock</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(5,757</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(5,757</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Less deemed dividend upon settlement of make-whole provision on Series A preferred stock</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(10,505</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">ap</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(10,505</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Less deemed dividend upon settlement of make-whole provision on Series B preferred stock</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(22,632</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">aq</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(22,632</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series A preferred stock</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(21,578</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">ar</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(21,578</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series B preferred stock</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(24,366</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">as</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(24,366</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Less cumulative dividends on Series A and Series B preferred stock</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(5,439</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,439</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">aw</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt; text-indent: -20pt; padding-left: 20pt">Add: losses allocated to participating securities</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">40,159</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">au</div></div></td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">40,159</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 2.5pt; text-indent: -20pt; padding-left: 20pt">Net loss attributable to Amyris, Inc. common stockholders</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(93,369</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">)</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(108,488</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(201,857</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-indent: -20pt; padding-left: 20pt">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Net loss per share attributable to common stockholders</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt; padding-left: 10pt">Basic and diluted</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2.89</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6.26</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Weighted-average shares of common stock outstanding used in computing loss per share of common stock:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt; padding-left: 10pt">Basic and diluted</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">32,253,570</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">32,253,570</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div>) Reclassification of revenue and operating expense by type to conform to the Company's current presentation.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><div style="display: inline; text-decoration: underline;">Restatement adjustments:</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">ab. Ginkgo partnership obligation and promissory note issuance recorded as reduction to revenue and correction of errors in recording revenue from non-cash consideration.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">ad. Correction in connection with a sales return, and adjustment to uninvoiced receipts liability.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">ae. Write-off of unrecoverable receivable in connection with facilities subleased to a related party, and reclassification of operating expense by classification to conform to the Company's current presentation.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">af. Expense incurred in connection with <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>equity offering.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">ah. Correction to amortization of debt discounts, and interest expense in connection with partnership payments obligation.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">ai. Correction to accounting for make-whole liability in connection with <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Offering.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">ak. Loss on extinguishment of related and unrelated party debt.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">am. Tax provision to accrue liability for unrecognized tax benefit.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">an. Loss on extinguishment of related and unrelated party debt.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">ap. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">aq. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">ar. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">as. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">au. Correction in the computation of loss per share to reflect participating securities.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">aw. Correction in the computation of net loss per share related to make-whole deemed dividends.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></div><div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"><div style="display: inline; font-weight: bold;"></div></div><div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <div style=" font-size: 10pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;">Consolidated Statement of Cash Flows</div></div> <div style=" font-size: 10pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">The following table presents the Company's consolidated statements of cash flows for the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017 </div>as previously reported, restatement adjustments and as restated (in thousands). In this table, As Restated amounts reflect the impact of corrections to the consolidated balance sheet as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017 </div>and the statement of operations for the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017, </div>as well as the Company's adoption of ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,</div> which changes how restricted cash is reported in statements of cash flows.</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</div> <div> <table style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;" cellspacing="0" cellpadding="0"> <tr style="vertical-align: bottom"> <td style="text-indent: 10pt">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="11" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Year Ended December 31, 2017</td> </tr> <tr style="vertical-align: bottom"> <td style="font-weight: bold; text-decoration: underline; text-indent: 0pt"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">As Previously Reported</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Corrections<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(1)</div></td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">As Restated</td> </tr> <tr style="vertical-align: bottom"> <td style="text-indent: 10pt">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-weight: bold; text-align: left; text-indent: 0pt">Operating activities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 61%; text-align: left; text-indent: 0pt">Net loss</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(72,329</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">)</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(83,653</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">)</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(155,982</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 0pt">Adjustments to reconcile net loss to net cash used in operating activities:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Depreciation and amortization</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,358</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,358</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">(Gain) loss on disposal of property, plant and equipment</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">142</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">142</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Stock-based compensation</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,265</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,265</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Amortization of debt discount</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,490</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,749</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15,239</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">(Gain) loss upon extinguishment of debt</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,521</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,376</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,897</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Receipt of equity in connection with collaboration arrangements revenue</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,661</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,661</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">(Gain) loss from change in fair value of derivative liabilities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,742</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">47,110</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">48,852</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">(Gain) loss on foreign currency exchange rates</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,230</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,230</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Noncash revenue reduction related to issuance of debt obligations</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,413</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,413</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Non-cash gain on divestiture</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(5,732</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(5,732</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Receipt of noncash consideration in connection with license revenue</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(8,046</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(8,046</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Changes in assets and liabilities:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 20pt">Accounts receivable</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(19,647</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(19,647</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 20pt"><div style=" text-align: left; text-indent: 20pt">Accounts receivable, unbilled &#x2013; related party</div> </td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(7,940</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(7,940</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 20pt">Inventories</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,126</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,126</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 20pt">Prepaid expenses and other assets</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(19,336</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(18,730</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 20pt">Accounts payable</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,858</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(406</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,452</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 20pt">Accrued and other liabilities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,295</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,582</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,877</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 20pt">Contract liabilities</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(7,241</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(7,241</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 30pt">Net cash used in operating activities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(100,617</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(562</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(101,179</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-weight: bold; text-align: left; text-indent: 0pt">Investing activities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Proceeds from divestiture</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">54,827</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">54,827</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Change in short-term investments</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">712</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">581</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,293</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Change in restricted cash</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">865</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(865</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Purchases of property, plant and equipment</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(4,412</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(4,412</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 20pt">Net cash (used in) provided by investing activities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">51,992</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(284</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">51,708</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-weight: bold; text-align: left; text-indent: 0pt">Financing activities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Proceeds from issuance of convertible preferred stock</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">101,124</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,878</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">98,246</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Proceeds from exercises of common stock options</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">160</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(160</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Payment of minimum employee taxes withheld upon net share settlement of restricted stock units</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(385</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(385</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Proceeds from issuance of common stock in August 2017 offering</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,759</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,759</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Issuance costs incurred</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,159</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,159</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Change in restricted cash related to contingently redeemable common stock</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,046</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,046</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Proceeds from issuance of debt, net of issuance costs</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,925</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,925</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Principal payments on debt</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(37,500</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(37,500</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Payment of swap termination</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,113</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,113</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Payment on early redemption of debt</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,909</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,909</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 20pt">Net cash provided by financing activities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">78,348</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(484</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">77,864</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 0pt">Effect of exchange rate changes on cash, cash equivalents and restricted cash</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">186</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">186</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Net (decrease) increase in cash, cash equivalents and restricted cash</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29,909</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,330</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28,579</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Cash, cash equivalents and restricted cash at beginning of year</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">27,150</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,283</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">32,433</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Cash, cash equivalents and restricted cash at end of year</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,059</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,953</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">61,012</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-indent: 10pt">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-weight: bold; text-align: left; text-indent: 0pt">Reconciliation of cash, cash equivalents and restricted cash to the consolidated balance sheets</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Cash and cash equivalents</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,059</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Restricted cash, current</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,994</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Restricted cash, noncurrent</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">959</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Total cash, cash equivalents and restricted cash</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">61,012</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-indent: 10pt">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-weight: bold; text-align: left; text-indent: 0pt">Supplemental disclosures of cash flow information:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 0pt">Cash paid for interest</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,539</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,539</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-weight: bold; text-align: left; text-indent: 0pt">Supplemental disclosures of non-cash investing and financing activities:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 0pt">Issuance of common stock upon conversion of debt</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28,702</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28,702</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 0pt">Accrued interest added to debt principal</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,816</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,816</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 0pt">Issuance of common stock for settlement of debt principal and interest payments</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,436</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,436</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 0pt">Financing of insurance premium under note payable</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">467</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">467</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 0pt">Issuance of convertible preferred stock upon conversion of debt</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">40,204</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">40,204</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 0pt">Settlement of debt principal by a related party</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 0pt">Issuance of note payable in exchange for debt extinguishment with third party</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,954</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,954</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 0pt">Issuance of common stock for settlement of debt</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,708</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,708</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 0pt">Issuance of preferred stock attributed to derivative liabilities</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">72,725</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">72,725</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div>) To reflect the impact of restatement corrections on the statement of cash flows.</div></div> 26844000 15515000 15921000 -406000 8000000 4300000 1071000 12823000 188000 1607000 90000 238000 1349000 14668000 1349000 4767000 9340000 -4573000 28979000 29202000 29402000 -200000 1173000 1694000 6440000 7818000 2300000 1600000 4900000 11400000 78631000 88269000 43300000 42200000 -43343000 -42156000 -42156000 8600000 600000 6800000 6265000 6265000 9190000 9190000 860000 176000 0 700000 6400000 2800000 200000 100000 1797000 2204000 7393000 4061000 9190000 6265000 2600000 3300000 642000 642000 501000 16602000 15239000 12490000 2749000 25986370 29921844 13703162 8203821 5392269 1338367 5294848 685007 2955732 4504212 53332381 44653251 25700000 127925000 140796000 151483000 -10687000 92215000 104001000 104607000 -606000 53199000 4153000 57352000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;">Basis of Consolidation</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The accompanying consolidated financial statements have been prepared in accordance with the accounting principles generally accepted in the United States (U.S. GAAP). The consolidated financial statements include the accounts of Amyris, Inc. and its wholly-owned and partially-owned subsidiaries in which the Company has a controlling interest after elimination of all significant intercompany accounts and transactions.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Investments and joint venture arrangements are assessed to determine whether the terms provide economic or other control over the entity requiring consolidation of the entity. Entities controlled by means other than a majority voting interest are referred to as variable-interest entities (VIEs) and are consolidated when Amyris has both the power to direct the activities of the VIE that most significantly impact its economic performance and the obligation to absorb losses or the right to receive benefits that could potentially be significant to the entity. For any investment or joint venture in which (i) the Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> have a majority ownership interest, (ii) the Company possesses the ability to exert significant influence and (iii) the entity is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> a VIE for which the Company is considered the primary beneficiary, the Company accounts for the investment or joint venture using the equity method. Following the adoption of ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">01</div> on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018 </div>described in more detail below (which was applicable to the Company on a prospective basis), equity investments in which the Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> exert significant influence and that do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> have readily determinable fair values are measured at cost, adjusted for changes from observable market transactions, less impairment (&#x201c;adjusted cost basis&#x201d;). The Company evaluates its investments for impairment by considering a variety of factors, including the earnings capacity of the related investments. Fair value measurements for the Company&#x2019;s equity investments are classified within Level <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div> of the fair value hierarchy based on the nature of the fair value inputs. Realized and unrealized gains or losses are recognized in other income or expense.</div></div></div></div></div></div></div></div></div></div></div></div> 484000 195000 217000 712000 513000 1000 198000 33000 679000 45353000 57059000 57059000 53199000 53199000 4153000 4153000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Cash and Cash Equivalents</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The Company considers all highly liquid investments purchased with an original or remaining maturity of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> months or less at the date of purchase to be cash equivalents. Cash and cash equivalents are maintained with various financial institutions.</div></div></div></div></div></div></div></div></div></div></div></div> 45400000 61012000 32433000 47054000 27150000 5283000 57059000 3953000 -13958000 28579000 29909000 -1330000 0.15 7 6.39 4.40 7.52 7.80 9.30 4.40 4.40 0.0015 4.40 6.30 4.40 4.40 6.39 4.40 0.15 2.87 7.52 2.87 3.90 2.87 5.12 5.02 3.90 4.76 5.02 5.02 5.02 4.56 3.90 5.12 2.87 3.90 3.31 5.12 1080000 190477 152381 19048 19048 171429 12.1 471204 7384190 7384190 3968116 1713565 5575118 1438829 4871795 5424804 3983230 1635025 1212787 258704 995024 2000000 181818 2000000 2000000 1080000 3205128 12097164 18042568 6292798 9543234 3968116 3616174 2082010 663228 171429 171429 81197 81197 1406 1406 29921844 26891512 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10.</div> Revenue Recognition</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Disaggregation of Revenue</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The following tables present revenue by primary geographical market, based on the location of the customer, as well as by major product and service:</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold">Years Ended December 31,<br /> (In thousands)</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center">(As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 72%">Europe</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29,405</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,823</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">United States</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">26,241</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">78,286</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Asia</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,331</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,290</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Brazil</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">942</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,159</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Other</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">685</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">113</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">63,604</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">127,671</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Significant Revenue Agreements</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">For <div style="display: inline; color: #231F20">the years ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> <div style="display: inline; font-size: 10pt">and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> the Company recognized revenue in connection with significant revenue agreements and from all other customers as follows:</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0; color: #231F20"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">Years Ended December 31, <br /> <div style="display: inline; text-decoration: underline;">(In thousands)</div></div></div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017 (As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Renewable Products</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Licenses and Royalties</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Grants and Collaborations</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">TOTAL</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Renewable Products</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Licenses and Royalties</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Grants and Collaborations</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">TOTAL</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Revenue from significant revenue agreements with:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 36%; text-align: left">DSM (related party)</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 5%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 5%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,958</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 5%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,735</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 5%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,711</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 5%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 5%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,972</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 5%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,679</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 5%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">59,651</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Firmenich</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,727</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,700</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,717</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,144</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,621</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,199</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,803</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,623</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>DARPA</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,436</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,436</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,333</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,333</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Givaudan</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,078</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,358</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,436</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,950</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,950</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Nenter</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,057</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,633</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">14,690</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Ginkgo</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(13,113</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(13,113</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Subtotal revenue from significant revenue agreements</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,823</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,658</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,246</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">38,727</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,628</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">48,691</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,815</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">98,134</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Revenue from all other customers</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,775</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(898</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,877</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,742</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,783</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29,537</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Total revenue from all customers</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">33,598</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,658</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">22,348</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">63,604</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,370</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">48,703</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">36,598</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">127,671</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Renewable <div style="display: inline; color: #231F20">Products</div></div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Firmenich Agreements</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;">&nbsp;</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In <div style="display: inline; color: #231F20"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2013,</div> the Company entered into a collaboration agreement with Firmenich SA (Firmenich) (as amended, the Firmenich Collaboration Agreement), for the development and commercialization of multiple renewable flavors and fragrances compounds. In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014,</div> the Company entered into a supply agreement with Firmenich (Firmenich Supply Agreement) for compounds developed under the Firmenich Collaboration Agreement.&nbsp;</div>The Firmenich Collaboration Agreement and&nbsp;<div style="display: inline; color: #231F20">Firmenich Supply Agreement (F</div>irmenich Agreements)&nbsp;are considered for revenue recognition purposes to comprise a single multiple-element arrangement.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2017,&nbsp;</div><div style="display: inline; color: #231F20">the&nbsp;</div>Company and Firmenich entered into an amendment of the Firmenich Collaboration Agreement, pursuant to which the parties agreed to exclude certain compounds from the scope of the agreement and to amend certain terms connected with the supply and use of such compounds when commercially produced. In addition, the parties agreed to (i) fix at a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">70/30</div> basis (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">70%</div> for Firmenich) the ratio at which the parties will share profit margins from sales of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> compounds; (ii) set at a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">70/30</div> basis (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">70%</div> for Firmenich) the ratio at which the parties will share profit margins from sales of a distinct form of compound until Firmenich receives <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$15.0</div> million more than the Company in the aggregate from such sales, after which time the parties will share the profit margins <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50/50</div> and (iii) a maximum Company cost of a compound where a specified purchase volume is satisfied, and alternative production and margin share arrangements in the event such Company cost cap is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> achieved.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2018, </div>the Company and Firmenich entered into a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">second</div> supply agreement (Firmenich Amended and Restated Supply Agreement), which incorporates all previous amendments and new changes and supersedes the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 2014 </div>supply agreement. With this Amended and Restated Supply Agreement, the parties agreed on the compounds to be supplied under the agreement and the commercial specifications of these products, and made some adjustments to the pricing of the compounds.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; color: #231F20">Pursuant to the Firmenich Collaboration Agreement, the Company agreed to pay a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div>-time success bonus to Firmenich of up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.5</div> million&nbsp;</div>if certain commercialization targets are met. Such targets have <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> yet been met as of <div style="display: inline; color: #231F20"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018.</div>&nbsp;</div>The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div>-time success bonus will expire upon termination of the Firmenich Collaboration Agreement, which has an initial term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div> years and will automatically renew at the end of such term (and at the end of any extension) for an additional <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div>-year term unless otherwise terminated. At <div style="display: inline; color: #231F20"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div></div>, the Company had a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.5</div> million liability associated with this <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div>-time success bonus <div style="display: inline; color: #231F20">that has been recorded as a reduction to the associated collaboration revenue.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Nenter Agreements</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 2016, </div>the Company and Nenter &amp; Co., Inc. (Nenter) entered into a renewable farnesene supply agreement (Nenter Supply Agreement) under which the Company agreed to supply farnesene and provide certain exclusive purchase rights, and Nenter committed to purchase minimum quantities and make quarterly royalty payments to the Company representing a portion of Nenter's profit on the sale of products produced using farnesene purchased under the agreement. The agreement expires <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2020 </div>and will automatically renew for an additional <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">five</div> years unless otherwise terminated. In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2017, </div>the Company assigned the Nenter Supply Agreement to DSM in connection with the Company's sale of its subsidiary Amyris Brasil Ltda., which owned and operated the Brotas, Brazil production facility; see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,</div> "Divestiture" and Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,</div> "Related Party Transactions" for additional information.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Licenses and Royalties</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; color: #231F20"><div style="display: inline; font-style: italic;">DSM </div></div><div style="display: inline; font-style: italic;">Agreements </div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">&nbsp;</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; color: #231F20"><div style="display: inline; font-style: italic;">DSM</div></div><div style="display: inline; font-style: italic;"> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 2017 </div>Collaboration and Licensing Agreements</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In<div style="display: inline; color: #231F20">&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July </div>and&nbsp;<div style="display: inline; color: #231F20"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September&nbsp;</div></div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> the Company entered into <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> separate collaboration agreements with DSM (DSM Collaboration Agreements) to jointly develop <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> new molecules in the Health &amp; Wellness (DSM Ingredients) market using the Company&#x2019;s technology, which the Company would produce and DSM would commercialize. Pursuant to the DSM Collaboration Agreements, DSM will, subject to certain conditions, provide funding for the development of the DSM Ingredients and, upon commercialization, the parties would enter into supply agreements whereby DSM would purchase the applicable DSM Ingredients from the Company at prices agreed by the parties. The development services will be directed by a joint steering committee with equal representation by DSM and the Company. In addition, the parties will share profit margin from DSM&#x2019;s sales of products that incorporate the DSM Ingredients subject to the DSM Collaboration Agreements.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In<div style="display: inline; color: #231F20">&nbsp;</div>connection with the entry into the DSM Collaboration Agreements, the Company and DSM also entered into certain license arrangements (DSM License Agreements) providing DSM with certain rights to use the technology underlying the development of the DSM Ingredients to produce and sell products incorporating the DSM Ingredients. Under the DSM License Agreements, DSM agreed to pay the Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$9.0</div> million for a worldwide, exclusive, perpetual, royalty-free license to produce and sell products incorporating <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> of the DSM Ingredients in the Health &amp; Wellness field.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">As discussed in Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,</div> &#x201c;Stockholders&#x2019; Deficit&#x201d;, the Company received <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$34.0</div> million of fixed consideration resulting from the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Offering and the DSM License Agreements, discussed above, and allocated this consideration to the various elements identified. The Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> allocated <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$10.6</div> million to the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Cash Warrants and DSM Dilution Warrants liabilities and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$15.6</div> million of the proceeds to the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Series B Preferred Stock. The remaining proceeds in excess of the fair value the equity awards and warrants of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$7.8</div> million was available for recognition as revenue generated from the delivery of the intellectual property licenses to DSM.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In connection with the entry into the DSM Agreements, the Company and DSM entered into the DSM Credit Letter, pursuant to which the Company granted a credit to DSM in an aggregate amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$12.0</div> million to be offset against future collaboration payments (in an amount <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> to exceed <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.0</div> million) and royalties receivable from DSM beginning in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018.</div>&nbsp; The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$7.8</div> million available for revenue recognition was reduced by an apportionment of the credit and allocated between delivered license revenue and future revenues associated with the collaboration agreements. This resulted in the recognition of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.3</div> million in licenses revenue under the DSM License Agreements and the remaining amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.5</div> million being recorded as deferred revenue. During the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> months ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017, </div>the Company and DSM terminated the DSM Credit Letter, eliminating the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$12.0</div> million credit from the DSM Collaboration Agreements. As a result of the cancelation of the Credit Letter, the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.5</div> million of deferred revenue was included as an element of consideration in the series of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2017 </div>DSM agreements described below, which were evaluated as a combined transaction for accounting purposes in conjunction with the sales of the Brotas <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div> facility discussed more fully in Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,</div> "Related Party Transactions" and Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,</div> "Divestiture".</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div><div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">DSM <div style="display: inline; color: #231F20">Value Sharing Agreement</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2017, </div>in conjunction with the Company's divestiture of its Brotas, Brazil production facility (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,</div> "Divestiture" and Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,</div> "Related Party Transactions"), the Company and DSM entered into a value sharing agreement (Value Sharing Agreement), pursuant to which DSM agreed to make certain royalty payments to the Company representing a portion of the profit on the sale of products produced using farnesene purchased under the Nenter Supply Agreement realized by Nenter and paid to DSM in accordance with the Nenter Supply Agreement. In addition, pursuant to the Value Sharing Agreement, DSM agreed to guarantee certain minimum annual royalty payments for the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> calendar years of the Value Sharing Agreement, subject to future offsets in the event that the royalty payments to which the Company would otherwise have been entitled under the Value Sharing Agreement for such years fall below certain milestones. The fair value of the nonrefundable minimum annual royalty payments were determined to be fixed and determinable, and were included as part of the total arrangement consideration subject to allocation of the overall multiple-element transaction that occurred in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2017 </div>with DSM. Under the Value Sharing Agreement, the Company is required to use certain royalty payments received by the Company with respect to the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> calendar years of the Value Sharing Agreement in excess of the guaranteed minimum annual royalty payments for such years, if any, to repay amounts outstanding under the DSM Credit Agreement; however, in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> the Company did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> receive royalty payments in excess of the guaranteed minimum annual amount. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> "Debt". The Value Sharing Agreement will expire in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2027, </div>subject to the right of each of the parties to terminate for uncured material breach by the other party or in the event the other party is subject to bankruptcy proceedings, liquidation, dissolution or similar proceedings or other specified events. During <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> the Company and DSM amended the Value Sharing Agreement to (i) provide for the use of estimates in calculating quarterly royalty payments (subject to true-up), (ii) modify how the guaranteed minimum annual royalty payment for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> will be offset against value payments accruing during <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and (iii) accelerate the minimum annual royalty payment for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018 </div>to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 30, 2018 </div>in exchange for a fee of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$750,000.</div> For the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018, </div>the Company recognized <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$7.9</div> million of revenue in connection with the DSM Value Sharing Agreement.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 2019, </div>the Company assigned to DSM all the Company&#x2019;s rights and obligations under the Value Sharing Agreement. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> &#x201c;Subsequent Events&#x201d; for additional information.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">DSM Performance Agreement</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2017, </div>in connection with the Company's divestiture of its Brotas, Brazil production facility (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,</div> "Divestiture"), the Company and DSM entered into a performance agreement (Performance Agreement), pursuant to which the Company will provide certain research and development services to DSM relating to the development of the technology underlying the farnesene-related products to be manufactured at the Brotas facility in exchange for related funding, including certain bonus payments in the event that specific performance metrics are achieved. The Company will record the bonus payments as earned revenue upon the transfer of the developed technology to DSM. If the Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> meet the established metrics under the Performance Agreement, the Company will be required to pay <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.8</div> million to DSM. The Performance Agreement will expire in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2020, </div>subject to the right of each of the parties to terminate for uncured material breach by the other party or in the event the other party is subject to bankruptcy proceedings, liquidation, dissolution or similar proceedings or other specified events.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 2019, </div>the Company and DSM amended the Performance Agreement. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> &#x201c;Subsequent Events&#x201d; for additional information.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">DSM <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2017 </div>Intellectual Property License Agreement</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2017, </div>in connection with the Company's divestiture of its Brotas, Brazil production facility (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,</div> "Divestiture"), the Company and DSM entered into a license agreement covering certain intellectual property of the Company useful in the performance of certain commercial supply agreements assigned by the Company to DSM relating to products currently manufactured at the Brotas facility (DSM <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2017 </div>Intellectual Property License Agreement). In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2017, </div>DSM paid the Company an upfront license fee of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$27.5</div> million. In accounting for the Divestiture with DSM, a multiple-element arrangement, the license of intellectual property to DSM was identified as revenue deliverable with standalone value and qualified as a separate unit of accounting. The Company performed an analysis to determine the fair value for of the license, and allocated the non-contingent consideration based on the relative fair value. The Company determined that the license had been fully delivered, and, as such, license revenue of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$54.6</div> million was recognized for the period ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31. 2017.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">DSM <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2017 </div>Supply Agreement and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018 </div>Supply Agreement Amendment</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 19, 2018, </div>the Company and DSM entered into an amendment (Supply Agreement Amendment) to the supply agreement, dated <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 28, 2017 (</div>Supply Agreement), by and between the Company and DSM. Under the Supply Agreement, DSM agreed to manufacture and supply to the Company certain products useful in the Company&#x2019;s business, at prices and on production and delivery terms and specifications set forth in the Supply Agreement, which prices are based upon DSM&#x2019;s manufacturing cost plus an agreed margin. The Supply Agreement originally provided that it would expire (i) with respect to non-farnesene related products, on the date that the Company&#x2019;s planned new specialty ingredients manufacturing facility in Brazil is fully operational and meets its production targets, but in any event <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> later than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2021 </div>and (ii) with respect to farnesene related products, on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 28, 2037, </div>subject in each case to earlier termination in certain circumstances. Pursuant to the Supply Agreement Amendment, (i) the outside expiration date of the Supply Agreement with respect to non-farnesene related products was extended to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2022, </div>with specified pricing terms added for products manufactured during <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2022,</div> (ii) DSM committed to produce certain non-farnesene related products for the Company for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> months of each calendar year during the term of the Supply Agreement and (iii) the Company agreed to (A) pay DSM a cash fee totaling <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$15.5</div> million, payable in installments during <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> (B) issue <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,643,991</div> shares of the Company's common stock to DSM, and (C) pay DSM a cash fee of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$7.3</div> million, payable on or before <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 29, 2019, </div>plus, if the closing price of the Common Stock on the trading day immediately preceding the date of such payment is less than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.41</div> per share, an amount equal to such deficiency multiplied by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,643,991.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company also entered into other transactions with DSM in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018 </div>which resulted in the Company (i) accounting for this series of transactions, including the Supply Agreement Amendment, and certain other transactions with DSM in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> as a combined arrangement, and (ii) determining and allocating the fair value to each element. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,</div> &#x201c;Related Party Transactions&#x201d; for additional information.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 2019, </div>the Company and DSM further amended the Supply Agreement. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> &#x201c;Subsequent Events&#x201d; for additional information.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">DSM <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018 </div>Letter Agreement</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 19, 2018, </div>the Company and DSM entered into a letter agreement (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018 </div>DSM Letter Agreement), pursuant to which the Company agreed (i) to cause the removal of certain existing liens on intellectual property owned by the Company and licensed to DSM and (ii) if such liens were <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> removed prior to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 15, 2018, </div>to issue to DSM shares of the Company&#x2019;s common stock with a value equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.0</div> million. On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 14, 2018, </div>the Company entered into an amendment to the GACP Term Loan Facility to remove such lien, and the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018 </div>DSM Letter Agreement was thereby terminated.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Ginkgo <div style="display: inline; color: #231F20">Agreements</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">&nbsp;</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Ginkgo Initial Strategic Partnership Agreement and Collaboration Agreement</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 2016, </div>the Company entered into a collaboration agreement (Initial Ginkgo Agreement) with Ginkgo Bioworks, Inc. (Ginkgo), pursuant to which the Company licensed certain intellectual property to Ginkgo in exchange for a fee of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$20.0</div> million to be paid by Ginkgo to the Company in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> installments, and a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10%</div> royalty on net revenue, including without limitation net sales, royalties, fees and any other amounts received by Ginkgo related directly to the license. The Company received the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> installment of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$15.0</div> million in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2016, </div>which the Company recognized as revenue in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016.</div> However, the Company did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> receive the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">second</div> installment of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.0</div> million, as the Company did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> meet the milestone criteria for the receipt of such payment.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 2016, </div>the Company and Ginkgo entered into a collaboration agreement (Ginkgo Collaboration Agreement) setting forth the terms of the Ginkgo Collaboration, under which the parties would collaborate to develop, manufacture and sell commercial products, and Ginkgo would pay royalties to the Company. The Ginkgo Collaboration Agreement provided that, subject to certain exceptions, all <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">third</div>-party contracts for the development of chemical small molecule compounds whose manufacture is enabled by the use of microbial strains and fermentation technologies that are entered into by the Company or Ginkgo during the term of the Ginkgo Collaboration Agreement would be subject to the Ginkgo Collaboration and the approval of the other party (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> to be unreasonably withheld). Responsibility for the engineering and small-scale process development of the newly developed products would be allocated between the parties on a project-by-project basis, and the Company would be principally responsible for the commercial scale-up and production of such products, with each party generally bearing its own respective costs and expenses relating to the Ginkgo Collaboration, including capital expenditures.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Under the Ginkgo Collaboration Agreement, subject to certain exceptions, including excluded or refused products and cost savings initiatives, the profit on the sale of products subject to the Ginkgo Collaboration Agreement as well as cost-sharing, milestone and &#x201c;value-creation&#x201d; payments associated with the development and production of such products would be shared equally between the parties. The parties also agreed to provide each other with a license and other rights to certain intellectual property necessary to support the development and manufacture of the products under the Ginkgo Collaboration, and also to provide each other with access to certain other intellectual property useful in connection with the activities to be undertaken under the Ginkgo Collaboration Agreement, subject to certain carve-outs.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Ginkgo Partnership Agreement</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2017, </div>the Company and Ginkgo entered into a partnership agreement (Ginkgo Partnership Agreement) to replace and supersede the Ginkgo Collaboration Agreement. Under the Ginkgo Partnership Agreement, the Company and Ginkgo agreed:</div> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; min-width: 700px;"> <tr style="vertical-align: top; text-align: justify"> <td style="width: 22.5pt; text-align: right">&nbsp;</td> <td style="width: 18pt">&#x2022;</td> <td style="text-align: justify">to continue to collaborate on limited research and development;</td> </tr> </table> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; min-width: 700px;"> <tr style="vertical-align: top; text-align: justify"> <td style="width: 22.5pt; text-align: right">&nbsp;</td> <td style="width: 18pt">&#x2022;</td> <td style="text-align: justify">to provide each other licenses (with royalties) to specified intellectual property for limited purposes;</td> </tr> </table> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; min-width: 700px;"> <tr style="vertical-align: top"> <td style="width: 22.5pt">&nbsp;</td> <td style="width: 18pt">&#x2022;</td> <td style="text-align: justify">for the Company to pay Ginkgo quarterly fees of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.8</div> million (Partnership Payments) for a total of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$12.7</div> million, beginning on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018 </div>and ending on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 30, 2022;</div></td> </tr> </table> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; min-width: 700px;"> <tr style="vertical-align: top"> <td style="width: 22.5pt">&nbsp;</td> <td style="width: 18pt">&#x2022;</td> <td style="text-align: justify">to share profit margins from sales of a certain product to be developed under the Ginkgo Partnership Agreement on a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50/50</div> basis, subject to certain conditions, provided that net profits will be payable to Ginkgo for any quarterly period to the extent that such net profits exceed the sum of (a) quarterly interest payments due under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2017 </div>Ginkgo Note (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> "Debt") and (b) Partnership Payments due in such quarter;</td> </tr> </table> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; min-width: 700px;"> <tr style="vertical-align: top"> <td style="width: 22.5pt">&nbsp;</td> <td style="width: 18pt">&#x2022;</td> <td style="text-align: justify">for the Company to issue the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$12</div> million Ginkgo Note which effectively guarantees Ginkgo <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$12</div> million minimum future royalties under the profit margin sharing provisions noted above; and</td> </tr> </table> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; min-width: 700px;"> <tr style="vertical-align: top"> <td style="width: 22.5pt">&nbsp;</td> <td style="width: 18pt">&#x2022;</td> <td style="text-align: justify">for the Company to pay Ginkgo <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.5</div> million in connection with certain fees previously owed to Ginkgo under the Ginkgo Collaboration Agreement.</td> </tr> </table> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Ginkgo Partnership Agreement provides for an initial term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years and will automatically renew for successive <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div>-year terms thereafter unless otherwise terminated. The Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> expect to recognize any future revenue under this arrangement.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company recorded the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.1</div> million present value of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$12.7</div> million partnership payments as an other liability (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,</div> "Balance Sheet Details"), with the remaining <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.6</div> million recorded as a debt discount to be recognized as interest expense under the effective interest method over the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">five</div>-year payment term. The Company also concluded the partnership payment obligation under the Ginkgo Partnership Agreement represents consideration payable to a former customer; and consequently, the present value of the partnership payments should be recorded as a reduction of cumulative revenue recognized to date from Ginkgo in the period the partnership agreement was executed. As a result, the Company recorded a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.1</div> million reduction in license revenues for the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017. </div>The Company reached a similar conclusion regarding the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$12.0</div> million Ginkgo Note (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> "Debt" under the &#x201c;Ginkgo Note&#x201d; section for further discussion regarding the accounting treatment of the Ginkgo Note) and recorded an additional <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$7.0</div> million reduction in license revenue for the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017 </div>related to the present value of the Ginkgo Note. In total, the Company recorded a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$13.1</div> million reduction in licenses and royalties revenue and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$13.1</div> million in notes payable and other liabilities as of and for the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017 </div>upon execution of the Ginkgo Partnership Agreement.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Collaborations</div></div></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">DARPA Technology Investment Agreement</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 2015, </div>the Company entered into a technology investment agreement (TIA) with The Defense Advanced Research Projects Agency (DARPA), under which the Company, with the assistance of specialized subcontractors, is working to create new research and development tools and technologies for strain engineering and scale-up activities. The agreement is being funded by DARPA on a milestone basis. Under the TIA, the Company and its subcontractors could collectively receive DARPA funding of up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$35.0</div> million over the program&#x2019;s <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">four</div> year term if all of the program&#x2019;s milestones are achieved. In conjunction with DARPA&#x2019;s funding, the Company and its subcontractors are obligated to collectively contribute approximately <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$15.5</div> million toward the program over its <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">four</div> year term (primarily by providing specified labor and/or purchasing certain equipment). For the DARPA agreement, the Company recognizes revenue using an output-based measure of progress of the milestones completed relative to remaining milestones, once acknowledged by DARPA.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Contract Assets and Liabilities</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">When a contract results in revenue being recognized in excess of the amount the Company has invoiced or has the right to invoice to the customer, a contract asset is recognized. Contract assets are transferred to accounts receivable, net when the rights to the consideration become unconditional. Contract assets are presented as Accounts receivable, unbilled &#x2013; related party on the consolidated balance sheets.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">Contract liabilities consist of payments received from customers, or such consideration that is contractually due, in advance of providing the product or performing services such that control has <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> passed to the customer.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">Trade receivables related to revenue from contracts with customers are included in accounts receivable on the consolidated balance sheets, net of the allowance for doubtful accounts. Trade receivables are recorded at the point of renewable product sale or in accordance with the contractual payment terms for licenses and royalties, and grants and collaborative research and development services for the amount payable by the customer to the Company for sale of goods or the performance of services, and for which the Company has the unconditional right to receive payment.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Contract Balances</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The following table provides information about accounts receivable and contract liabilities from contracts with customers:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold; border-bottom: Black 1pt solid"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">December 31, <br /> <div style="display: inline; text-decoration: underline;">(In thousands)</div></div></div></td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 64%; text-align: left">Accounts receivable, net</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,003</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,953</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Accounts receivable - related party, net</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,349</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,767</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Accounts receivable, unbilled - related party</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,021</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,901</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Accounts receivable, unbilled, noncurrent - related party</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,203</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,940</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td><div style="display: inline; font-size: 10pt">Contract liabilities<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(1)</div></div></td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,236</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,308</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left"><div style="display: inline; font-size: 10pt">Contract liabilities, noncurrent<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(2)</div></div></td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,587</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div>)&nbsp;&nbsp;&nbsp;&nbsp; </div>The balance in contract liabilities, current at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017 </div>represents deferred revenue, current prior to the Company's adoption of ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606,</div> "Revenue".</div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div>)&nbsp;&nbsp;&nbsp;&nbsp; </div>The balances in contract liabilities, noncurrent are included in other noncurrent liabilities on the consolidated balance sheets.&nbsp;</div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Unbilled receivables relate to the Company&#x2019;s right to consideration from DSM for (i) minimum future royalties and (ii) a material right arising from a customer option for a future transfer of technology. The Company&#x2019;s right to cash receipt for these minimum royalty amounts occurs on or before <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2019, </div>and the right to cash receipt for the customer option occurs on or before <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2020.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">Contract liabilities, current increased by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.9</div> million at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> resulting from a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.8</div> million increase upon adoption of ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606</div> on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018 </div>plus the net amount of collaboration and royalty revenues invoiced in excess of amounts recognized as revenue, less <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.3</div> million of revenue recognized during the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> that was included in deferred revenue at the beginning of the period.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Remaining Performance Obligations</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The following table provides information regarding the estimated revenue expected to be recognized in the future related to performance obligations that are unsatisfied (or partially unsatisfied) based on the Company's existing agreements with customers as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; text-align: left; text-decoration: underline"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">As of December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 79%; text-align: left">2019</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 18%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">14,131</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2020</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,925</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">2021</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2022 and thereafter</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Total from all customers</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">22,056</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In accordance with the disclosure provisions of ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606,</div> the table above excludes estimated future revenues for performance obligations that are part of a contract that has an original expected duration of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> year or less or a performance obligation with variable consideration that is recognized using the sales-based royalty exception for licenses of intellectual property. Additionally, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$21.4</div> million of estimated future revenue is excluded from the table above, as that amount represents constrained variable consideration.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div></div> 0.10 0.0001 0.0001 0.0001 250000000 250000000 76564829 45637433 76564829 45637433 81197 50000000 0 0 8000 5000 5000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Stock-based Compensation</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The Company accounts for stock-based employee compensation plans under the fair value recognition and measurement provisions of U.S. GAAP. Those provisions require all stock-based payments to employees, including grants of stock options and restricted stock units (RSUs), to be measured using the grant-date fair value of each award. The Company recognizes stock-based compensation expense net of expected forfeitures over each award's requisite service period, which is generally the vesting term. Expected forfeiture rates are estimated based on the Company's historical experience. Stock-based compensation plans are described more fully in Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,</div> "Stock-based Compensation".</div></div></div></div></div></div></div></div></div></div></div></div> -231422000 -157234000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Concentration of Credit Risk</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Financial instruments that potentially subject the Company to a concentration of credit risk consist primarily of cash and cash equivalents, short-term investments and accounts receivable. The Company places its cash equivalents and investments (primarily certificates of deposits) with high credit quality financial institutions and, by policy, limits the amount of credit exposure with any <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> financial institution. Deposits held with banks <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>exceed the amount of insurance provided on such deposits. The Company has <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> experienced any losses on its deposits of cash and cash equivalents and short-term investments.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The Company performs ongoing credit evaluation of its customers, does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> require collateral, and maintains allowances for potential credit losses on customer accounts when deemed necessary.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Customers representing <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10%</div> or greater of accounts receivable were as follows:</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div> <table style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;" cellspacing="0" cellpadding="0" align="center"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; border-bottom: Black 1pt solid">As of December 31,</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 60%; text-align: left">Customer B</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24</div></td> <td style="white-space: nowrap; width: 8%; text-align: left">%</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div></td> <td style="white-space: nowrap; width: 8%; text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Customer C</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19</div></td> <td style="white-space: nowrap; text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15</div></td> <td style="white-space: nowrap; text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Customer G </td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11</div></td> <td style="white-space: nowrap; text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">**</div></td> <td style="white-space: nowrap; text-align: left"></td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Customer A (related party)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">**</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">38</div></td> <td style="white-space: nowrap; text-align: left">%</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">______________</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-size: 8pt">** Less than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10%</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: -0.25in"><div style="display: inline; font-style: italic;">&nbsp;</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Customers representing <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10%</div> or greater of revenue were as follows:</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div> <table style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;" cellspacing="0" cellpadding="0" align="center"> <tr style="vertical-align: bottom"> <td style="font-weight: bold; border-bottom: Black 1pt solid">Years Ended December 31,</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center">(As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 60%; text-align: left">Customer A (related party)</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">17</div></td> <td style="width: 8%; text-align: left">%</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">46</div></td> <td style="width: 8%; text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Customer B</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18</div></td> <td style="text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div></td> <td style="text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Customer C</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div></td> <td style="text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">**</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Customer D</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div></td> <td style="text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">**</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Customer E</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">**</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11</div></td> <td style="text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Customer F</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">**</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">**</td> <td style="text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">______________</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-size: 8pt"></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-size: 8pt">** Less than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10%</div></div></div></div></div></div></div></div></div></div></div></div></div></div> 0.24 0.1 0.19 0.15 0.11 0.38 0.17 0.46 0.18 0.13 0.13 0.13 0.11 <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold; border-bottom: Black 1pt solid"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">December 31, <br /> <div style="display: inline; text-decoration: underline;">(In thousands)</div></div></div></td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 64%; text-align: left">Accounts receivable, net</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,003</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,953</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Accounts receivable - related party, net</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,349</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,767</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Accounts receivable, unbilled - related party</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,021</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,901</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Accounts receivable, unbilled, noncurrent - related party</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,203</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,940</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td><div style="display: inline; font-size: 10pt">Contract liabilities<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(1)</div></div></td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,236</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,308</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left"><div style="display: inline; font-size: 10pt">Contract liabilities, noncurrent<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(2)</div></div></td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,587</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> </table></div> 13100000 22700000 8021000 9901000 9901000 1203000 7940000 7940000 4500000 34700000 24400000 2100000 1204000 383000 800000 3300000 8236000 4308000 4880000 -572000 21000000 1587000 3300000 3300000 12700000 22140 89528 1394706 20921 0 36698000 62307000 62713000 -406000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Cost of Products Sold</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Cost of products sold includes the production costs of renewable products, which include the cost of raw materials, in-house manufacturing labor and overhead, amounts paid to contract manufacturers, including amortization of tolling fees, and period costs including inventory write-downs resulting from applying lower of cost or net realizable value inventory adjustments. Cost of products sold also includes certain costs related to the scale-up of production. Shipping and handling costs charged to customers are recorded as revenues. Outbound shipping costs incurred are included in cost of products sold. Such charges were <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> material for any of the periods presented.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0">The Company recognizes deferred cost of products sold as an asset on the balance sheet when a cost is incurred in connection with a revenue performance obligation that will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> be fulfilled until a future period.</div></div></div></div></div></div></div></div></div></div></div></div> 200187000 183722000 182959000 763000 -762000 -762000 6564000 964000 7546000 18000 2019 2025 2018 2025 1767632 3448821 2226105 30729 2333 3479008 1122460 2500000 1767632 4877386 370404 1 3700000 3400000 38200000 71000000 70000000 13500000 5000000 10000000 9700000 53300000 4700000 4700000 53300000 63600000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.</div> Debt</div></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">December 31, </div></div><br /> <div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; text-decoration: underline;">(In thousands)</div></div></div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="15" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="11" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td style="white-space: nowrap">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Principal</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Unamortized <br /> Debt <br /> (Discount) <br /> Premium</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Change in <br /> Fair Value</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Net</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Principal</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Unamortized <br /> Debt <br /> (Discount) <br /> Premium</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Net</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-style: italic; text-align: left">Convertible notes payable</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-weight: bold;">(As Restated, Note 2)</div></div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 37%; text-align: left">6% convertible notes due 2021</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60,000</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,082</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">)</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,918</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; width: 1%; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">2015 Rule 144A convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">37,887</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,413</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">35,474</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">37,887</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(9,458</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28,429</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2014 Rule 144A convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,004</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(867</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,137</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,004</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,170</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">20,834</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">August 2013 financing convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,415</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(70</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,345</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,009</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,126</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,883</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>December 2017 convertible notes</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,000</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(25</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,975</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">126,306</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,350</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,082</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">120,874</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">70,900</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(14,779</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">56,121</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-style: italic; text-align: left">Related party convertible notes payable</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">2014 Rule 144A convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,705</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,038</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,667</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,705</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,784</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">20,921</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">August 2013 financing convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">21,711</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">897</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">22,608</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">R&amp;D note</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,700</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(18</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,682</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,705</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,038</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,667</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50,116</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,905</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">47,211</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-style: italic; text-align: left">Loans payable and credit facilities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">GACP term loan facility</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">36,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,349</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">34,651</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Ginkgo note</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(4,047</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,953</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(4,862</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,138</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Other loans payable</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,910</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,047</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,863</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,463</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,277</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,186</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Senior secured loan facility</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28,566</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(253</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28,313</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Other credit facilities</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">381</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">381</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">52,910</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,443</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">46,467</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">47,410</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,392</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">41,018</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-style: italic; text-align: left">Related party loans payable</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">DSM note</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,311</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,689</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(8,039</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,961</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>February 2016 private placement</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Other DSM loan</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">393</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">393</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,311</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,689</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">27,393</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(8,039</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19,354</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Total debt</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">228,921</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(17,142</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">)</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,082</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">209,697</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">195,819</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(32,115</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">163,704</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Less: current portion</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(147,677</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(56,943</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Long-term debt, net of current portion</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">62,020</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">106,761</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">Future minimum payments under the debt agreements as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> are as follows:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold; text-align: left">Years ending December&nbsp;31<br /> (In thousands)</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Convertible Notes</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Loans<br /> Payable and Credit Facilities</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Related Party Convertible Notes</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Related Party Loans Payable and Credit Facilities</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 45%; text-align: left">2019</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 8%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">134,368</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 8%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,219</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 8%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,508</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 8%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,500</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 8%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">172,595</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2020</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,981</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,500</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,481</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">2021</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">34,740</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">27,521</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">62,261</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2022</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,417</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,417</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">2023</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">367</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">367</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Thereafter</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,200</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,200</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Total future minimum payments</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">134,368</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">70,924</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,508</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">32,521</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">263,321</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left"><div style="display: inline; font-size: 10pt">Less: amount representing interest<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(1)</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(7,368</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(18,014</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(803</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(7,521</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(33,706</div></td> <td style="text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Less: future conversion of accrued interest to principal</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(694</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(694</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Present value of minimum debt payments</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">126,306</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">52,910</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,705</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">228,921</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Less: current portion of debt principal</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(126,306</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,829</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(24,705</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(154,840</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Noncurrent portion of debt principal</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">49,081</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">74,081</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: left; margin-top: 0pt; margin-right: 0; margin-bottom: 0pt">______________</div> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; min-width: 700px;"> <tr style="vertical-align: top"> <td style="width: 0">&nbsp;</td> <td style="width: 0.25in"><div style="display: inline; font-size: 10pt"><div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div>)</div></div></td> <td><div style="display: inline; font-size: 10pt">Excluding net debt discount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$17.1</div> million that will be amortized to interest expense over the term of the debt.</div></td> </tr> </table> <div style=" font-size: 10pt; text-indent: -9pt; margin: 0pt 0 0pt 0.25in"></div> <div style=" font-size: 10pt; text-indent: -9pt; margin: 0pt 0 0pt 0.25in"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div style=" font-size: 10pt; margin: 0pt 0 0pt 0.25in"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Convertible Notes Payable</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">&nbsp;</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 6, 2018, </div>the Company entered into a securities purchase agreement to issue and sell <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$60.0</div> million in aggregate principal amount of senior convertible notes (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div>) that are convertible into shares of the Company&#x2019;s common stock. The securities purchase agreement prohibits the Company, subject to certain exceptions, from (i) disposing of any common stock or securities convertible into or exchangeable for shares of common stock during the period commencing on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 6, 2018 </div>and continuing through the later of (A) the date <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">90</div> days after <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 10, 2018 </div>and (B) the date <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">30</div> days after the Registration Statement (as defined below) is declared effective and (ii) effecting or entering into an agreement to effect any issuance involving a variable rate transaction for so long as the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> remain outstanding.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The closing of the issuance and sale of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> occurred on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 10, 2018, </div>for net proceeds, after deducting offering expenses payable by the Company and placement agent and advisory fees, of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$56.2</div> million.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> are general unsecured obligations of the Company. Unless earlier converted or redeemed, the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> will mature on the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">third</div> anniversary of issuance, subject to the rights of the holders to extend the maturity date in certain circumstances. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> are convertible from time to time, at the election of the holders, into shares of common stock at an initial conversion price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.32</div> per share. The conversion price is subject to adjustment in the event of any stock split, reverse stock split, recapitalization, reorganization or similar transaction. The Company has the option, upon prior notice to the holders, to settle any conversion of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> in cash.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> are payable in equal monthly installments beginning <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 1, 2019 (</div>each, an Installment Date), in either cash at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">108%</div> of such installment amount or, at the Company&#x2019;s option, subject to the satisfaction of certain equity conditions (the Equity Conditions), in shares of common stock at a discount to the then-current market price, subject to a price floor (the Installment Conversion Price). The holders have the right, upon notice to the Company, to defer all or any portion of any installment amount to a future Installment Date. In addition, if the Company elects to pay any installments in shares of common stock, the holders of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> have the right to accelerate amounts outstanding under their <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> during such month up to an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> times the relevant installment amount.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> bear interest at a rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> per annum, payable quarterly until the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> Installment Date, and then at each Installment Date thereafter. Interest on the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be paid in either cash or, at the Company&#x2019;s option, subject to the satisfaction of the Equity Conditions, shares of common stock at the Installment Conversion Price. The Company elected to make the interest payment due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2019 </div>in cash.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> contain customary terms and covenants, including (i) a restriction on the Company&#x2019;s ability to incur additional indebtedness, (ii) certain events of default, after which the holders <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>require the Company to redeem all or any portion of their <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> in cash at a price equal to the greater of (A) <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">125%</div> of the amount being redeemed and (B) the intrinsic value of the shares of common stock underlying the amount being redeemed, and (iii) certain other events, after which the holders <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>convert all or any portion of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> at a discount to the Installment Conversion Price.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In the event of a Fundamental Transaction (as defined in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div>), holders of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>require the Company to redeem all or any portion of their <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> at a price equal to the greater of (i) <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">125%</div> of the amount being redeemed and (ii) a premium to the intrinsic value of the shares of Common Stock underlying the amount being redeemed.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">Notwithstanding the foregoing, the holders will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> have the right to convert any portion of a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Note Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021,</div> and the Company will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> have the option to pay any amount in shares of common stock, if (a) the holder, together with its affiliates, would beneficially own in excess of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.99%</div> (or such other percentage as determined by the holder and notified to the Company in writing, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> to exceed <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9.99%,</div> provided that any increase of such percentage will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> be effective until <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">61</div> days after notice thereof) of the number of shares of common stock outstanding immediately after giving effect to such conversion or payment, as applicable (the Ownership Limitation), or (b) the aggregate number of shares issued with respect to the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> (and any other transaction aggregated for such purpose) after giving effect to such conversion or payment, as applicable, would exceed <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15,271,047</div> shares of common stock (the Exchange Cap), unless the Company has obtained prior stockholder approval to issue shares in excess of the Exchange Cap. In the event that (i) the Company is prohibited from issuing any shares of common stock under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> as a result of the Ownership Limitation (other than in connection with a conversion of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div>), such shares shall be held in abeyance (and the related principal amount of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> reinstated) until the holder shall notify the Company and elect to receive such shares without exceeding the Ownership Limitation, and (ii) the Company is prohibited from issuing any shares of common stock under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> as a result of the Exchange Cap, the Company will pay cash in lieu of any shares that would otherwise be deliverable in excess of the Exchange Cap.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In connection with the offering of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021,</div> the Company entered into a registration rights agreement, dated <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 10, 2018, </div>with the purchasers of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021,</div> pursuant to which the Company agreed to file a registration statement (the Registration Statement) with the Securities and Exchange Commission (the SEC) registering the resale of all of the shares of common stock issuable pursuant to the terms of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> (the Registrable Securities) under the Securities Act of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1933,</div> as amended (the Securities Act), within <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">30</div> days following <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 10, 2018, </div>and to have the Registration Statement declared effective by the SEC by the date that is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60</div> days after <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 10, 2018. </div>In the event that the Registration Statement is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> filed or declared effective within the foregoing time frames, or if thereafter, subject to certain exceptions, the Registration Statement is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> effective for any reason or the prospectus contained therein is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> available for use by the holders, Company shall pay to each holder an amount in cash equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2%</div> of such holder&#x2019;s original principal amount of Notes on the date of such failure and thereafter on every <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">30</div> day anniversary thereof until such failure is cured or <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> longer prevents the holders from freely disposing of their Registrable Securities. The Company filed the Registration Statement on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 8, 2019, </div>and it went effective on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 7, 2019.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The Company has elected to account for the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> at fair value pursuant to U.S. GAAP, as of the issuance date. Management believes that the fair value option better reflects the underlying economics of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021,</div> which contain multiple embedded derivatives. Under the fair value election, changes in fair value will be reported in the consolidated statements of operations as "Gain (loss) from change in fair value of debt" in each reporting period subsequent to the issuance of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021.</div> For the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> the Company recorded a gain of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.1</div> million, which is shown as Change in Fair Value in the table at the beginning of this Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.</div> See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,</div> "Fair Value Measurement" for information about the assumptions that the Company used to measure the fair value of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2019, </div>the Company exchanged the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> for new senior convertible notes and warrants to purchase common stock. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> &#x201c;Subsequent Events&#x201d; for additional information.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 2015, </div>the Company sold <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$57.6</div> million aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9.50%</div> convertible senior notes due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes) to certain qualified institutional buyers in a private placement. Net proceeds from the offering were <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$54.4</div> million after payment of offering expenses and placement agent fees, which together are treated as a debt discount and are being amortized over the remaining loan term using the effective interest method. The Company used <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$18.3</div> million of the net proceeds to repurchase <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$22.9</div> million aggregate principal amount of outstanding <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes as discussed below. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes bear interest at a rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9.50%</div> per year, payable semiannually in arrears on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 15 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 15 </div>of each year. Interest on the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes is payable, at the Company's option, entirely in cash or entirely in common stock valued at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">92.5%</div> of a market-based price. The Company elected to make the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 15, 2016 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 15, 2018 </div>interest payments in shares of common stock and the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 15, 2016 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 15, 2018 </div>interest payments in cash. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes matured on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 15, 2019. </div>See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> "Subsequent Events".</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes are convertible into shares of the Company's common stock at a conversion rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">61.7246</div> shares per <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1,000</div> principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes (which conversion rate is subject to adjustment in certain circumstances), representing an effective conversion price of approximately <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$16.20</div> per share as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018.</div> If converted prior to maturity, noteholders are entitled to receive a payment (the Early Conversion Payment) equal to the present value of the remaining scheduled payments of interest on the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes being converted through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 15, 2019, </div>computed using a discount rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">0.75%.</div> The Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>make the Early Conversion Payment, at its election, either in cash or, subject to certain conditions, in common stock valued at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">92.5%</div> of a market-based price. Through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> the Company has elected to make each Early Conversion Payment in shares of common stock.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 2017, </div>the Company issued an additional <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$19.1</div> million in aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes (the Additional <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes) in exchange for the cancellation of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$15.3</div> million in aggregate principal amount of other outstanding convertible promissory notes of the Company, with the same terms as the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes; provided, that the aggregate number of shares issued with respect to the Additional <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes (and any other transaction aggregated for such purpose) cannot exceed <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,652,935</div> shares of common stock without prior stockholder approval. The exchange was accounted for as an extinguishment of debt, resulting in a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.1</div> million gain in the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017, </div>the Company exchanged <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.7</div> million in aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes for shares of its Series B <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">17.38%</div> Convertible Preferred Stock and warrants to purchase common stock, as described in more detail in Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,</div> &#x201c;Stockholders&#x2019; Deficit&#x201d;. The exchange was accounted for as an extinguishment of debt, resulting in a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.0</div> million loss in the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 16, 2019, </div>the Company repaid the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes in full in cash. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> &#x201c;Subsequent Events&#x201d;.&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2014, </div>the Company sold <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$75.0</div> million in aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6.50%</div> Convertible Senior Notes due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes) to qualified institutional buyers in a private placement. The net proceeds from the offering were <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$72.0</div> million after payment of initial purchaser discounts and offering expenses, which together are treated as a debt discount and are being amortized over the remaining loan term.&nbsp;The Company used <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$9.7</div> million of the net proceeds to repay convertible notes previously issued to an affiliate of Total S.A. (together with its affiliates, Total), representing the amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes purchased by Total. Certain of the Company's affiliated entities (including Total) purchased <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$24.7</div> million in aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes bear interest at an annual rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6.5%,</div> payable semiannually in arrears on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 15 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 15 </div>of each year in cash. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes mature on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> unless earlier converted or repurchased.&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes are convertible into shares of the Company's common stock at a conversion rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">17.8073</div> shares per <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1,000</div> principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes (which conversion rate is subject to adjustment in certain circumstances), representing an effective conversion price of approximately <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$56.16</div> per share as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017, </div>the Company exchanged <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.4</div> million in aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes for shares of its Series B <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">17.38%</div> Convertible Preferred Stock and warrants to purchase common stock, as described in more detail in Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,</div> &#x201c;Stockholders&#x2019; Deficit". The exchange was accounted for as an extinguishment, resulting in a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.8</div> million loss for the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2019, </div>the Company exchanged a portion of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes, representing <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$38.2</div> million aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes, for shares of common stock, warrants to purchase common stock and a new senior convertible note (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> &#x201c;Subsequent Events&#x201d; for additional information) and repaid the remaining portion of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes in cash at maturity.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2013 </div>Financing Convertible Notes</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2013, </div>the Company entered into a Securities Purchase Agreement (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2013 </div>SPA) with Total and Temasek to sell up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$73.0</div> million in convertible notes in private placements (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2013 </div>Financing or the Tranche Notes). The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2013 </div>SPA provided for the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2013 </div>Financing to be divided into <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> tranches, each with differing closing conditions. The Tranche I Notes were due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">sixty</div> months from the date of issuance (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 16, 2018). </div>Interest accrued on the Tranche I Notes at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5%</div> per <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">six</div> months, compounded semiannually, and was payable in kind by adding to the principal or in cash. Through maturity, the Company elected to pay interest on the Tranche I Notes in kind. The Tranche I Notes totaling <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$15.2</div> million of principal and accrued interest matured and were repaid in full by conversion into shares of common stock on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 16, 2018 </div>pursuant to the Maturity Treatment Agreement terms (see &#x201c;Related Party Convertible Notes Payable - <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2013 </div>Financing Convertible Notes&#x201d; below). Upon conversion of the Tranche I Notes, the Company recognized a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$10.9</div> million loss upon extinguishment of debt in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018.</div> See the "Maturity Treatment Agreement" section below for details of the impact of that agreement on the Tranche Notes.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The Tranche II Notes are due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">sixty</div> months from the date of issuance (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 15, 2019). </div>Interest accrues on the Tranche II Notes at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10%</div> per annum, compounded annually, and is payable in kind by adding to the principal or in cash. Through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> the Company has elected to repay interest on the Tranche II Notes in kind. On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 8, 2018, </div>the Company repaid in full the Tranche II Notes held by Total totaling <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$9.8</div> million of principal and accrued interest by conversion into shares of common stock pursuant to the Maturity Treatment Agreement terms (see &#x201c;Related Party Convertible Notes Payable - <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2013 </div>Financing Convertible Notes&#x201d; below). Upon conversion of the Tranche II Notes held by Total, the Company recognized a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.5</div> million loss upon extinguishment of debt.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2018, </div>in connection with certain amendments to the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Cash Warrants (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,</div> &#x201c;Stockholders' Deficit&#x201d;), the conversion price of the Tranche Notes I and II was reduced from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.2977</div> per share to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.40</div> per share. As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> the conversion price of the remaining Tranche II Notes held by Wolverine Flagship Fund Trading Limited (Wolverine) is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.40</div> per share (which conversion price is subject to adjustment in certain circumstances, including certain price-based anti-dilution adjustments). The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2013 </div>SPA and the Tranche Notes contain customary terms, covenants and restrictions, including a limit on the Company&#x2019;s debt, subject to certain exceptions and waivers, of the greater of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$200</div> million or <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50%</div> of its consolidated total assets and the Company&#x2019;s secured debt of the greater of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$125</div> million or <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">30%</div> of its consolidated total assets. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2013 </div>SPA also requires the Company to obtain the consent of the holders of a majority of these notes before completing any change of control transaction or purchasing assets in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> transaction or in a series of related transactions in an amount greater than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$20.0</div> million, in each case while any Tranche Notes are outstanding. In addition, the Tranche Notes contain certain events of default after which the Tranche Notes <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>become due and payable immediately.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 14, 2019, </div>Wolverine agreed to waive payment of the Tranche II Note held by Wolverine at maturity until <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 15, 2019 </div>in exchange for a cash waiver fee, payable on or prior to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 15, 2019, </div>of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.6</div> million. On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2, 2019, </div>the Company and Wolverine entered into an exchange agreement whereby the parties agreed to extinguish the Tranche II Note held by Wolverine in exchange for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,767,632</div> shares of common stock and a warrant to purchase <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,080,000</div> shares of common stock. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> &#x201c;Subsequent Events&#x201d; for additional information.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Maturity Treatment Agreement</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2015, </div>the Company entered into an Exchange Agreement (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Exchange Agreement) with Total and Temasek pursuant to which Temasek exchanged <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$71.0</div> million in principal amount of outstanding Tranche Notes and Total exchanged <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$70.0</div> million in principal amount of outstanding convertible notes for shares of the Company's common stock at a price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$34.50</div> per share (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Exchange). At the closing of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Exchange, the Company, Total and Temasek also entered into a Maturity Treatment Agreement dated <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 29, 2015, </div>pursuant to which Total and Temasek agreed to convert any Tranche Notes or <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Notes held by them that were <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> canceled in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Exchange (Remaining Notes) into shares of the Company's common stock in accordance with the terms of such Remaining Notes at or prior to maturity, provided that certain events of default had <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> occurred with respect to the applicable Remaining Notes. In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017, </div>the Company entered into separate letter agreements with each of Total and Temasek, pursuant to which the Company agreed that the Remaining Notes consisting of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Notes held by Total (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$9.7</div> million in principal amount as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div>) and Temasek (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$10.0</div> million in principal amount as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div>) would <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> longer be subject to mandatory conversion at or prior to the maturity of such Remaining Notes. Accordingly, the Company will be required to pay any portion of such Remaining Notes that remain outstanding at maturity in cash in accordance with the terms of such Remaining Notes. As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> after giving effect to such letter agreements, Temasek did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> hold any Remaining Notes and Total held <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$21.8</div> million in principal amount of Remaining Notes (consisting of Tranche Notes), which Remaining Notes were converted to common stock in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018 </div>pursuant to the terms of the Maturity Treatment Agreement (see below under "Related Party Convertible Notes Payable - <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2013 </div>Financing Convertible Notes" for more information). The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Exchange Agreement contains customary terms, covenants and restrictions, including a limit on the Company&#x2019;s debt of the greater of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$200</div> million or <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50%</div> of its consolidated total assets and the Company&#x2019;s secured debt of the greater of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$125</div> million or <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">30%</div> of its consolidated total assets, subject to certain exceptions.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2017 </div>Convertible Note</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2017, </div>the Company issued and sold a convertible note under an <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 2017 </div>securities purchase agreement in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.0</div> million with a maturity date of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 1, 2018, </div>for proceeds to the Company of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.0</div> million. The Company identified certain embedded feature that required bifurcation, but the fair value of these derivative features was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0,</div> due primarily to the short-term maturity of the note and a significant out of the money conversion price at issuance and through the maturity date. The Company elected to pay each installment in cash, and the note was repaid in full in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2018.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Related Party Convertible Notes Payable</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2013 </div>Financing Convertible Notes</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">Certain of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2013 </div>Financing Convertible Notes were held by related parties; see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,</div> "Related Party Transactions" for details.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 16, 2018, </div>the Tranche I Notes held by Total totaling <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$15.2</div> million of principal and accrued interest reached maturity and were converted into <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,448,821</div> shares of common stock. Upon conversion of the Tranche I Notes, the Company recognized a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$10.9</div> million loss upon extinguishment of debt.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 8, 2018, </div>Total converted its Tranche II Notes totaling <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$9.8</div> million of principal and accrued interest, which were scheduled to mature on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 15, 2019, </div>into shares of common stock. In connection with such conversion, the Company agreed to pay Total future interest on the Tranche II Notes being converted up to, but excluding, the maturity date for such notes, which interest was converted by Total into common stock at the conversion price for the Tranche II Notes. As a result of such conversion, the Tranche II Notes held by Total converted into <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,226,105</div> shares of common stock. Upon conversion of the Tranche II Notes held by Total, the Company recognized a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.5</div> million loss upon extinguishment of debt.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">Certain of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes are held by related parties. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,</div> "Related Party Transactions" for details.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">R&amp;D Note</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 2016, </div>as a result of the restructuring of the Company&#x2019;s fuels joint venture with Total, Total Amyris BioSolutions B.V., the Company issued to Total an unsecured convertible note (the R&amp;D Note) in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.7</div> million, representing the remaining portion of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$105.0</div> million convertible note facility between the Company and Total initially established in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2012.</div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2018, </div>the Company and Total amended the R&amp;D Note to extend the maturity to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 31, 2018 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2, 2018, </div>respectively, with accrued and unpaid interest payable on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 31, 2018, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 31, 2018 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2, 2018. </div>On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2, 2018, </div>the Company repaid the R&amp;D Note in full.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Loans Payable and Credit Facilities</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">GACP <div style="display: inline; font-size: 10pt">Term Loan Facility</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 29, 2018, </div>the Company, certain of the Company&#x2019;s subsidiaries and GACP Finance Co., LLC (GACP) entered into a Loan and Security Agreement (the LSA) to borrow a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$36.0</div> million secured term loan (the GACP Term Loan Facility). The LSA also provides for an incremental secured term loan facility in an aggregate principal amount of up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$35.0</div> million (the Incremental GACP Term Loan Facility and, together with the GACP Term Loan Facility, the GACP Term Loan Facilities), subject to certain conditions and approvals, to fund the construction of a custom-built manufacturing facility in Brazil. The majority of the net proceeds from the GACP Term Loan Facility were used to repay all amounts outstanding under the Senior Secured Loan Facility between the Company and Stegodon described below. The remaining net proceeds were used on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2, 2018 </div>to repay amounts outstanding under the R&amp;D Note at maturity, as described above.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">Loans under the GACP Term Loan Facilities have a maturity date of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 1, 2021; </div>provided, that if the Company has <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> (i) met certain financial conditions on or prior to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 7, 2019 </div>or (ii) refinanced the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes with indebtedness that has a maturity date which is later than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 1, 2021 </div>or converted such notes into equity prior to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 12, 2019, </div>then the maturity date will be <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 12, 2019. </div>See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> &#x201c;Subsequent Events&#x201d; for additional information about the waiver of this provision. The GACP Term Loan Facilities will amortize beginning on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 1, 2019 </div>in quarterly installments equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2.5%</div> of the original loan amounts, with the remaining principal balance payable on the maturity date. Loans under the GACP Term Loan Facilities initially accrued interest at a rate per annum equal to the sum of (i) the greater of (A) the U.S. prime rate as reported in the Wall Street Journal and (B) <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.0%,</div> plus (ii) <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6.25%,</div> payable monthly. The GACP Term Loan Facilities are guaranteed by the subsidiaries of the Company party to the LSA and collateralized by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div>-priority liens on substantially all the Company&#x2019;s and such subsidiaries&#x2019; assets, including intellectual property, subject to certain exceptions. The LSA includes customary terms, covenants and restrictions, including mandatory prepayments upon the occurrence of certain events, including asset sales, casualty events, incurrence of additional indebtedness and borrowing base deficiencies, subject to certain exceptions and reinvestment rights. The LSA contains certain financial covenants that include quarterly minimum revenues, minimum liquidity amounts and a minimum asset coverage ratio.</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The Company paid origination fees at closing equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4%,</div> or <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.4</div> million, of the funded amount of the GACP Term Loan Facility and other closing costs totaling <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.2</div> million, plus an agency fee of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$25,000</div> per quarter during the term of the GACP Term Loan Facilities. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.6</div> million of issuance costs will be amortized using the effective interest method over the expected <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div>-year loan term.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018, </div>the Company and GACP amended the LSA to reduce the minimum revenue requirement for the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> fiscal quarters ending <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018 </div>in exchange for an increase in optional prepayment fees, an increase in the minimum liquidity amount and an increase in the base interest rate per annum, from the sum of (i) the greater of (A) the prime rate as reported in the Wall Street Journal or (B)&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.0%</div> plus (ii)&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6.25%</div> to the sum of (i) the greater of (A) the prime rate as reported in the Wall Street Journal or (B)&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.0%</div> plus (ii)&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8.25%.</div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2018, </div>the Company and GACP further amended the LSA to exclude certain intellectual property licensed to DSM from the loan collateral (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> &#x201c;Revenue Recognition&#x201d; for more information) in exchange for a further increase in the base interest rate per annum, from the sum of (i) the greater of (A) the prime rate as reported in the Wall Street Journal or (B)&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.0%</div> plus (ii)&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8.25%</div> to the sum of (i) the greater of (A) the prime rate as reported in the Wall Street Journal or (B)&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.75%</div> plus (ii)&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9.00%.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 2019, (</div>i) GACP provided a waiver to the Company for breaches of all covenant violations under the GACP loan and security agreement (LSA) occurring prior to, as of and after <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018 </div>through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 8, 2019, </div>and (ii) GACP sold and assigned the loans under the LSA and all documents and assets related thereto to Foris Ventures, LLC (Foris). Subsequently, Foris provided a waiver to the Company for breaches of certain covenants under the LSA through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 30, 2020 </div>and amended the financial covenants under the LSA to provide more favorable compliance terms and conditions. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> "Subsequent Events" for additional information.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Senior Secured Loan Facility</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 2014, </div>the Company entered into a Loan and Security Agreement (the LSA) with Hercules Technology Growth Capital, Inc. to make available to the Company a secured loan facility (the Senior Secured Loan Facility) in an initial aggregate principal amount of up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$25.0</div> million. The LSA was subsequently amended in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 2014, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 2015 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2015 </div>to (i) extend additional credit facilities to the Company in an aggregate amount of up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$31.0</div> million, of which <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$16.0</div> million was drawn by the Company, (ii) extend the maturity date of the loans, and (iii) remove, add and/or modify certain covenants and agreements under the LSA.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 2016, </div>Hercules transferred and assigned its rights and obligations under the Senior Secured Loan Facility to Stegodon Corporation (Stegodon), an affiliate of Ginkgo Bioworks, Inc. (Ginkgo).</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2018, </div>the Company and Stegodon amended the LSA to extend the date for a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.5</div> million principal payment to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 31, 2018 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2, 2018, </div>respectively. Under the amendments, the interest rate from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 1, 2018 </div>through the date of such <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.5</div> million principal payment would be the previously agreed interest rate plus <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.0%.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 29, 2018, </div>the Company repaid the Senior Secured Loan Facility in full.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Ginkgo Note</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2017, </div>the Company issued an unsecured promissory note in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$12.0</div> million to Ginkgo (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2017 </div>Ginkgo Note) in connection with the termination of the Ginkgo Collaboration Agreement and the execution of a new partnership agreement (the Ginkgo Partnership Agreement), which is described in Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> "Revenue Recognition". The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2017 </div>Ginkgo Note bears interest at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10.5%</div> per annum, payable monthly, and has a maturity date of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 19, 2022. </div>The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2017 </div>Ginkgo Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be prepaid in full without penalty or premium at any time, provided that certain payments have been made under the Company&#x2019;s partnership agreement with Ginkgo. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2017 </div>Ginkgo Note also contains customary terms, covenants and restrictions, including certain events of default after which the note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>become due and payable immediately. The Company recorded the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$7.0</div> million present value of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2017 </div>Ginkgo Note as a note payable liability, and the remaining <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.0</div> million was recorded as a debt discount which is being accreted to interest expense over the loan term using the effective interest method. Also, the Company concluded that while <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> cash was received from Ginkgo under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2017 </div>Ginkgo Note, the transaction represents consideration payable to a former customer and the present value of the note payable obligation should be recorded as a reduction of cumulative revenue recognized to date from Ginkgo in the period the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2017 </div>Ginkgo Note was executed. As a result, the Company recorded a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$7.0</div> million reduction of license revenues as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017. </div>See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> "Revenue Recognition" for additional information.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Other Loans Payable</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">&nbsp;</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Nikko Note:</div>&nbsp;In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2016, </div>in connection with the Company's formation of its cosmetics joint venture (the Aprinnova JV) with Nikko Chemicals Co., Ltd. (Nikko) made a loan to the Company in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.9</div> million and the Company issued a promissory note (the Nikko Note) to Nikko in an equal principal amount. The proceeds of the Nikko Note were used to satisfy the Company's remaining liabilities related to the Company's purchase of a manufacturing facility in Leland, North Carolina and related assets in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2016, </div>including liabilities under a promissory note in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.5</div> million issued in connection therewith. The Nikko Note (i) bears interest at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5%</div> per year, (ii) has a term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div> years, (iii) is payable in equal monthly installments of principal and interest beginning on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2017 </div>and (iv) is secured by a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div>-priority lien on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10%</div> of the Aprinnova JV interests owned by the Company. In addition, (i) the Company repaid <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$400,000</div> of the Nikko Note in equal monthly installments of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$100,000</div> as required on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2017, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 1, 2017, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 1, 2017 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 1, 2017 </div>and (ii) the Company is required to repay the Nikko Note with any profits distributed to the Company by the Aprinnova JV, beginning with the distributions for the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">fourth</div> fiscal year of the Aprinnova JV, until the Nikko Note is fully repaid. The Nikko Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be prepaid in full or in part at any time without penalty or premium. The Nikko Note contains customary terms and provisions, including certain events of default after which the Nikko Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>become due and payable immediately.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Aprinnova Working Capital Loans:&nbsp;</div>In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 2017, </div>in connection with the formation of the Aprinnova JV in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2016, </div>Nikko made a working capital loan to the Aprinnova JV in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.5</div> million and received a promissory note from the Aprinnova JV in an equal amount (the First Aprinnova Note). The First Aprinnova Note was repayable in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$375,000</div> installments plus accrued interest on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 1, 2017, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 1, 2017, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 1, 2017 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 1, 2018. </div>The First Aprinnova Note was fully repaid in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 2018. </div>In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017, </div>Nikko made a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">second</div> working capital loan to the Aprinnova JV in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.5</div> million and received a promissory note from the Aprinnova JV in an equal amount (the Second Aprinnova Note). The Second Aprinnova Note is payable in full on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 1, 2019, </div>with interest payable quarterly. Both notes bear interest at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2.75%</div> per annum. Effective <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 31, 2019, </div>the Company and Nikko agreed to extend the term of the Second Aprinnova Note to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 1, 2020. </div>See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> "Subsequent Events".</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Related Party Loans Payable</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">DSM Note</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2017, </div>the Company and DSM entered into a credit agreement (the DSM Credit Agreement) to make available to the Company an unsecured credit facility of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$25.0</div> million. On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 28, 2017, </div>the Company borrowed <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$25.0</div> million under the DSM Credit Agreement, representing the entire amount available thereunder, and issued a promissory note to DSM in an equal principal amount (the DSM Note). The Company used the proceeds of the amounts borrowed under the DSM Credit Agreement to repay all outstanding principal under a promissory note in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$25</div> million issued to Guanfu Holding Co., Ltd. in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2016 (</div>the Guanfu Note). Given multiple elements in the arrangements with DSM, the Company fair valued the DSM Note to determine the arrangement consideration that should be allocated to the DSM Note. The fair value of the DSM Note was discounted using a Company specific weighted average cost of capital rate that resulted in a debt discount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.0</div> million. The debt discount is being amortized over the loan term using the effective interest method.</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The DSM Note (i) is an unsecured obligation of the Company, (ii) matures on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2021 </div>and (iii) accrues interest from and including <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 28, 2017 </div>at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10%</div> per annum, payable quarterly. The DSM Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be prepaid in full or in part at any time without penalty or premium. In addition, the Company is required to use certain payments received by the Company from DSM under the Value Sharing Agreement (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> &#x201c;Revenue Recognition&#x201d;) to repay amounts outstanding under the DSM Credit Agreement. The DSM Credit Agreement and the DSM Note contain customary terms, covenants and restrictions, including certain events of default after which the DSM Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>become due and payable immediately.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 2016 </div>Private Placement</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 2016, </div>the Company issued and sold <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$20.0</div> million in aggregate principal amount of promissory notes (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 2016 </div>Notes), as well as warrants to purchase an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">190,477</div> shares of the Company's common stock, exercisable at a price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.15</div> per share as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 2016 </div>Warrants), resulting in aggregate proceeds to the Company of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$20.0</div> million, in a private placement to certain existing stockholders of the Company that are affiliated with members of the Company's Board of Directors (the Board): Foris Ventures, LLC (Foris, an entity affiliated with director John Doerr of Kleiner Perkins Caufield &amp; Byers, a current stockholder, and an owner of greater than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">five</div> percent of the Company&#x2019;s outstanding common stock), which purchased <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$16.0</div> million aggregate principal amount of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 2016 </div>Notes and warrants to purchase <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">152,381</div> shares of the Company's common stock; Naxyris S.A. (Naxyris, an investment vehicle owned by Naxos Capital Partners SCA Sicar; director Carole Piwnica is Director of NAXOS UK, which is affiliated with Naxos Capital Partners SCA Sicar, and was designated as a director of the Company by Naxyris), which purchased <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.0</div> million aggregate principal amount of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 2016 </div>Notes and warrants to purchase <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19,048</div> shares of the Company's common stock; and Biolding Investment SA (Biolding, a fund affiliated with director HH Sheikh Abdullah bin Khalifa Al Thani, who was designated as a director of the Company by Biolding), which purchased <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.0</div> million aggregate principal amount of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 2016 </div>Notes and warrants to purchase <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19,048</div> shares of the Company's common stock.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 2016 </div>Notes bore interest at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13.50%</div> per annum and had an initial maturity date of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 15, 2017. </div>In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017, </div>the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 2016 </div>Notes purchased by Foris and Naxyris were exchanged for shares of the Company&#x2019;s Series B <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">17.38%</div> Convertible Preferred Stock and warrants to purchase common stock; see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,</div> &#x201c;Stockholders&#x2019; Deficit&#x201d;.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017, </div>the Company and Biolding amended the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 2016 </div>Note issued to Biolding (the Biolding Note) to extend the maturity of the Biolding Note to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 15, 2017, </div>and on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 13, 2017, </div>the Company and Biolding further amended the Biolding Note to extend the maturity to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017. </div>The Company paid the Biolding Note in full on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 2, 2018.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 2016 </div>Warrants each have <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">five</div>-year terms. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 2016 </div>Warrants purchased by Naxyris were fully exercised in the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017, </div>and a gain of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.1</div> million was recorded in earnings. As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">none</div> of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">171,429</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 2016 </div>Warrants purchased by Foris or Biolding have been exercised.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">For information regarding related party loans payable subsequent to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018, </div>see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> &#x201c;Subsequent Events&#x201d;.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Letters of Credit</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 2012, </div>the Company entered into a letter of credit agreement for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.0</div> million under which it provided a letter of credit to the landlord for its headquarters in Emeryville, California in order to cover the security deposit on the lease. This letter of credit is secured by a certificate of deposit. Accordingly, the Company has <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.0</div> million of restricted cash, noncurrent in connection with this arrangement as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017.</div></div></div> 0.04 0.0625 0.04 0.04 0.04 0.0475 0.09 0.12 0.0025 60000000 9700000 10000000 21800000 12000000 71000000 60000000 37887000 37887000 24004000 24004000 4415000 4009000 5000000 126306000 70900000 24705000 24705000 21711000 3700000 24705000 50116000 36000000 12000000 12000000 4910000 6463000 28566000 381000 52910000 47410000 25000000 25000000 2000000 393000 25000000 27393000 228921000 195819000 9705000 9705000 21711000 3700000 9705000 35116000 25000000 25000000 393000 25000000 25393000 2000000 5000000 5000000 10000000 10000000 49705000 77509000 6.32 16.20 56.16 5.2977 4.40 4.40 34.50 5.2977 4.40 17.8073 9493672 2338560 1003554 867376 13703162 15300000 12000000 60000000 60000000 57600000 73000000 5000000 105000000 36000000 25000000 12000000 3900000 1500000 1500000 20000000 500000 1500000 32500000 8000000 8500000 8000000 19000000 3000000 3000000 2000000 68300000 3000000 2000000 10435000 12500000 8000000 149300000 156900000 7000000 1000000 500000 0.065 0.05 0.06 0.06 0.06 0.095 0.095 0.0625 0.0825 0.0825 0.09 0.105 0.05 0.0275 0.1 0.135 0.0175 0.0475 0 0.125 0.125 0.12 0.125 0.105 0.12 0.18 0.05 0.12 0.12 0.125 0.125 0.125 0.086 375000 6400000 3200000 18300000 3700000 22900000 P13Y P1Y180D P4Y 17100000 6600000 17100000 5000000 8000000 2413000 9458000 867000 3170000 70000 2126000 25000 3350000 14779000 1038000 3784000 -897000 18000 1038000 2905000 1349000 4047000 4862000 1047000 1277000 253000 6443000 6392000 6311000 8039000 6311000 8039000 17142000 32115000 422000 1538000 -897000 18000 422000 659000 6311000 8039000 6311000 8039000 181000 660000 435000 1591000 7349000 10949000 151700000 165400000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Debt Extinguishment</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 12pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The Company accounts for the income or loss from extinguishment of debt in accordance with ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">470,</div> <div style="display: inline; font-style: italic;">Debt,</div> which indicates that for all extinguishment of debt, the difference between the reacquisition consideration and the net carrying amount of the debt being extinguished should be recognized as gain or loss when the debt is extinguished. Losses from debt extinguishment are shown in the consolidated statements of operations under "Other income (expense)" as "Loss upon extinguishment of debt".</div></div></div></div></div></div></div></div></div></div></div></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold">December 31,<br /> (In thousands)</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="text-align: center"><div style="display: inline; font-weight: bold;">(As Restated, Note 2)</div></td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 66%; text-align: left">Prepayments, advances and deposits</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,644</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,599</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Recoverable taxes from Brazilian government entities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">631</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">87</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Other</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,291</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,233</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Total prepaid expenses and other current assets</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,566</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,919</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> -669000 -669000 3750000 6539000 1587000 383000 127775000 87625000 27888000 32085000 156000 57921000 20066000 3114000 3584000 9269000 9653000 12046000 9480000 6496000 5471000 8526000 7286000 124025000 81086000 386867000 3750000 6539000 6582000 6582000 2465000 2462000 4921000 11358000 11358000 0.0394 -8500000 600000 113100000 1200000 1800000 3800000 39500000 0 200000 41272000 108887000 1524000 7610000 42796000 116497000 42796000 116497000 119978000 -3481000 0.025 0.03 0.017 0.024 0.172 0.273 0.184 0.285 0.45 0.85 0.45 0.8 0 0.05 0.146 0.249 0.166 0.267 22000000 6600000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Derivatives</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Embedded derivatives that are required to be bifurcated from the underlying debt instrument (i.e., host) are accounted for and valued as separate financial instruments. The Company has evaluated the terms and features of its convertible notes payable and convertible preferred stock and identified compound embedded derivatives requiring bifurcation and accounting at fair value, using the valuation techniques mentioned in the <div style="display: inline; font-style: italic;">Fair Value Measurements</div> section of this Note, because the economic and contractual characteristics of the embedded derivatives met the criteria for bifurcation and separate accounting due to the instruments containing conversion options, certain &#x201c;make-whole interest&#x201d; provisions, down-round conversion price adjustment provisions and/or conversion rate adjustments.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> </div> <!-- Field: Page; Sequence: 16 --> <!-- Field: /Page --> <div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Cash warrants and anti-dilution warrants issued in conjunction with the convertible debt and equity financings are freestanding financial instruments which are also classified as derivative liabilities.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div></div></div></div></div></div></div></div></div></div></div></div></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold">Years Ended December 31,<br /> (In thousands)</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center">(As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 72%">Europe</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29,405</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,823</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">United States</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">26,241</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">78,286</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Asia</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,331</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,290</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Brazil</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">942</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,159</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Other</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">685</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">113</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">63,604</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">127,671</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12.</div> Stock-based Compensation</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Stock-based Compensation Expense Related to All Plans</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Stock-based compensation expense related to all employee stock compensation plans, including options, restricted stock units and ESPP, was as follows:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">Years Ended December 31, </div></div><br /> <div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; text-decoration: underline;">(In thousands)</div></div></div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 62%; text-align: left">Research and development</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 16%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,797</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 16%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,204</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Sales, general and administrative</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,393</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,061</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Total stock-based compensation expense</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,190</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,265</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;"></div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"></div></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">&nbsp;</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Plans</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> Equity Incentive Plan</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company's <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> Equity Incentive Plan (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> Equity Plan) became effective on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">27,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> and will terminate in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2020.</div> The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> Equity Plan provides for the granting of common stock options, restricted stock awards, stock bonuses, stock appreciation rights, restricted stock units (RSUs) and performance awards. It allows for time-based or performance-based vesting for the awards. Options granted under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> Equity Plan <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be either incentive stock options (ISOs) or non-statutory stock options (NSOs). ISOs <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be granted only to Company employees (including officers and directors who are also employees). NSOs <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be granted to Company employees, non-employee directors and consultants. The Company will be able to issue <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> more than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,000,000</div> shares pursuant to the grant of ISOs under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> Equity Plan. Options under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> Equity Plan <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be granted for periods of up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">ten</div> years. All options issued to date have had a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">ten</div>-year life. Under the plan, the exercise price of any ISOs and NSOs <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> be less than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100%</div> of the fair market value of the shares on the date of grant. The exercise price of any ISOs and NSOs granted to a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10%</div> stockholder <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> be less than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">110%</div> of the fair value of the underlying stock on the date of grant. The options and RSUs granted to-date generally vest over <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">five</div> years.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> options were outstanding to purchase <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,339,214</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,255,045</div> shares, respectively, of the Company's common stock granted under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> Equity Plan, with weighted-average exercise prices per share of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$33.40</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$26.29,</div> respectively. In addition, as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> restricted stock units representing the right to receive <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,294,803</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">683,554</div> shares, respectively, of the Company's common stock granted under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> Equity Plan were outstanding. As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,359,750</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">252,107</div> shares, respectively, of the Company&#x2019;s common stock remained available for future awards that <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be granted under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> Equity Plan.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The number of shares reserved for issuance under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> Equity Plan increases automatically on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1 </div>of each year starting with <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2011,</div> by a number of shares equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5%</div> of the Company&#x2019;s total outstanding shares as of the immediately preceding <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31.</div> However, the Company&#x2019;s Board of Directors or the Leadership Development and Compensation Committee of the Board of Directors retains the discretion to reduce the amount of the increase in any particular year.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2018, </div>shareholders approved amendments to the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> Equity Plan to (i) increase the number of shares of common stock available for grant and issuance thereunder by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9.0</div> million shares and (ii) increase the annual per-participant award limit thereunder to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.0</div> million shares. Subsequent to the amendments, the total number of shares available for grant was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,280,000,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> including the annual evergreen increases.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"></div></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2005</div> Stock Option/Stock Issuance Plan</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2005,</div> the Company established its <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2005</div> Stock Option/Stock Issuance Plan (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2005</div> Plan) which provided for the granting of common stock options, restricted stock units, restricted stock and stock purchase rights awards to employees and consultants of the Company. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2005</div> Plan allowed for time-based or performance-based vesting for the awards. Options granted under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2005</div> Plan were ISOs or NSOs. ISOs were granted only to Company employees (including officers and directors who are also employees). NSOs were granted to Company employees, non-employee directors, and consultants.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">All options issued under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2005</div> Plan had a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">ten</div>-year life. The exercise prices of ISOs and NSOs granted under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2005</div> Plan were <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> less than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100%</div> of the estimated fair value of the shares on the date of grant, as determined by the Board of Directors. The exercise price of an ISO and NSO granted to a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10%</div> stockholder could <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> be less than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">110%</div> of the estimated fair value of the underlying stock on the date of grant as determined by the Board. The options generally vested over <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5</div> years.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> options to purchase <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">52,389</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">79,322</div> shares, respectively, of the Company&#x2019;s common stock granted under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2005</div> Plan remained outstanding, and as a result of the adoption of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> Equity Plan discussed above, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">zero</div> shares of the Company&#x2019;s common stock remained available for future awards issuance under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2005</div> Plan. The options outstanding under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2005</div> Plan as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div> had a weighted-average exercise price per share of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$185.93</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$144.58,</div> respectively.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">&nbsp;</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> Employee Stock Purchase Plan</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> Employee Stock Purchase Plan (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> ESPP) became effective on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">27,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010.</div> The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> ESPP is designed to enable eligible employees to purchase shares of the Company&#x2019;s common stock at a discount. Offering periods under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> ESPP generally commence on each <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 16 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 16, </div>with each offering period lasting for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> year and consisting of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two six</div>-month purchase periods. The purchase price for shares of common stock under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> ESPP is the lesser of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">85%</div> of the fair market value of the Company&#x2019;s common stock on the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> day of the applicable offering period or the last day of each purchase period. During the life of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> ESPP, the number of shares reserved for issuance increases automatically on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1 </div>of each year, starting with <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2011,</div> by a number of shares equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1%</div> of the Company&#x2019;s total outstanding shares as of the immediately preceding <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31.</div> However, the Company&#x2019;s Board of Directors or the Leadership Development and Compensation Committee of the Board of Directors retains the discretion to reduce the amount of the increase in any particular year. In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2018, </div>shareholders approved an amendment to the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> ESPP to increase the maximum number of shares of common stock that <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be issued over the term of the ESPP by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div> million shares. <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">No</div> more than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,666,666</div> shares of the Company&#x2019;s common stock <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be issued under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> ESPP and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> other shares <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be added to this plan without the approval of the Company&#x2019;s stockholders.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> CEO Performance-based Stock Options</div></div> <div style=" font-size: 10pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2018, </div>the Company granted its chief executive officer performance-based stock options (PSOs) to purchase <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,250,000</div> shares. PSOs are equity awards with the final number of PSOs that <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>vest determined based on the Company&#x2019;s performance against pre-established EBITDA milestones and Amyris stock price milestones. The EBITDA milestones are measured from the grant date through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2021, </div>and the stock price milestones are measured from the grant date through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2022. </div>The PSOs vest in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">four</div> tranches contingent upon the achievement of both the EBITDA milestones and stock price milestones for each respective tranche, and the chief executive officer&#x2019;s continued employment with the Company. Over the measurement periods, the number of PSOs that <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be issued and the related stock-based compensation expense that is recognized is adjusted upward or downward based upon the probability of achieving the EBITDA milestones. Depending on the probability of achieving the EBITDA milestones and stock price milestones and certification of achievement of those milestones for each vesting tranche by the Company&#x2019;s Board of Directors or Compensation Committee, the PSOs issued could be from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">zero</div> to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,250,000</div> stock options, with an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.08</div> per share.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Stock-based compensation expense for this award is recognized using a graded-vesting approach over the service period beginning at the grant date through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2022, </div>as the Company&#x2019;s management has determined that certain EBITDA milestones are probable of achievement over the next <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">four</div> years as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> The Company utilized a Monte Carlo simulation to estimate the grant date fair value of each tranche of the award which totaled <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.1</div> million. For the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> the Company recognized <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.7</div> million of compensation expense for this award. The assumptions used to estimate the fair value of this award with performance and market vesting conditions were as follows:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold">Stock Option Award with Performance and Market Vesting Conditions:</td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 84%; text-align: left">Fair value of the Company&#x2019;s common stock on grant date</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.08</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Expected volatility</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">70</div></td> <td style="white-space: nowrap; text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Risk-free interest rate</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2.75</div></td> <td style="white-space: nowrap; text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Dividend yield</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">0.0</div></td> <td style="white-space: nowrap; text-align: left">%</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 12pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Stock Option Activity</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Stock option activity is summarized as follows:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; text-decoration: underline"><div style="display: inline; text-decoration: underline;">Year ended December 31,</div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 68%; text-align: left">Options granted</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,337,119</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">661,094</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Weighted-average grant-date fair value per share</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.18</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3.26</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Compensation expense related to stock options (in millions)</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2.6</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3.3</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Unrecognized compensation costs as of December 31 (in millions)</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8.5</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2.7</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company expects to recognize the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> balance of unrecognized costs over a weighted-average period of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3.8</div> years. Future option grants will increase the amount of compensation expense to be recorded in these periods.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Stock-based compensation expense for stock options and employee stock purchase plan rights is estimated at the grant date and offering date, respectively, based on the fair-value using the Black-Scholes option pricing model. The fair value of employee stock options is amortized on a ratable basis over the requisite service period of the awards. The fair value of employee stock options and employee stock purchase plan rights was estimated using the following weighted-average assumptions:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold">Years Ended December 31,</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Expected dividend yield</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;%</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;%</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 74%; text-align: left">Risk-free interest rate</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2.8</div></td> <td style="white-space: nowrap; width: 5%; text-align: left">%</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2.1</div></td> <td style="white-space: nowrap; width: 5%; text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Expected term (in years)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6.90</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6.12</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Expected volatility</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">80</div></td> <td style="white-space: nowrap; text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">84</div></td> <td style="white-space: nowrap; text-align: left">%</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 27pt; margin: 0pt 0">The expected life of options is based primarily on historical share option exercise experience of the employees for options granted by the Company. All options are treated as a single group in the determination of expected life, as the Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> currently expect substantially different exercise or post-vesting termination behavior among the employee population. The risk-free interest rate is based on the U.S. Treasury yield for a term consistent with the expected life of the awards in effect at the time of grant. Expected volatility is based on the historical volatility of the Company's common stock. The Company has <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> history or expectation of paying dividends on common stock.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 27pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 27pt; margin: 0pt 0">Stock-based compensation expense associated with options is based on awards ultimately expected to vest. At the time of an option grant, the Company estimates the expected future rate of forfeitures based on historical experience. These estimates are revised, if necessary, in subsequent periods if actual forfeiture rates differ from those estimates. If the actual forfeiture rate is lower than estimated the Company will record additional expense and if the actual forfeiture is higher than estimated the Company will record a recovery of prior expense.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 27pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 27pt; margin: 0pt 0">The Company&#x2019;s stock option activity and related information for the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> was as follows:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 27pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Number of <br /> Stock <br /> Options</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Weighted-<br /> average <br /> Exercise <br /> Price</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; text-align: center; border-bottom: Black 1pt solid"><div style="display: inline; font-weight: bold;">Weighted-average <br /> Remaining <br /> Contractual <br /> Life</div> <br /> (in years)</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; text-align: center; border-bottom: Black 1pt solid"><div style="display: inline; font-weight: bold;">Aggregate <br /> Intrinsic <br /> Value</div> <br /> (in thousands)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 48%">Outstanding - December 31, 2017</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,338,367</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">33.40</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7.7</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">97</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Options granted</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,337,119</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.18</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Options exercised</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(70,807</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3.68</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Options forfeited or expired</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(214,409</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19.61</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Outstanding - December 31, 2018</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,390,270</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11.55</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8.5</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Vested or expected to vest after December 31, 2018</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,833,615</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12.28</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8.4</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Exercisable at December 31, 2018</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">972,229</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">39.73</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.8</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The aggregate intrinsic value of options exercised under all option plans was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.2</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0</div> for the years ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> respectively, determined as of the date of option exercise.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Restricted Stock Units Activity and Expense</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">During the years ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,452,664</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">523,167</div> RSUs, respectively, were granted with weighted-average service-inception date fair value per unit of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.36</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.51,</div> respectively.&nbsp;The Company recognized RSU-related stock-based compensation expense of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.4</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.8</div> million, respectively, for the years ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017.</div> As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> unrecognized RSU-related compensation costs totaled <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$23.8</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.0</div> million, respectively.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Stock-based compensation expense for RSUs is measured based on the closing fair market value of the Company's common stock on the date of grant.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company&#x2019;s RSU and restricted stock activity and related information for the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> was as follows:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Number of <br /> Restricted <br /> Stock Units</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Weighted-<br /> average <br /> Grant-date<br /> Fair Value</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Weighted-<br /> average <br /> Remaining <br /> Contractual<br /> Life<br /> (in years)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 58%">Outstanding - December 31, 2017</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">683,554</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8.66</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1.4</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Awarded</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,452,664</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.36</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Vested</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(445,828</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8.43</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Forfeited</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(395,587</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.64</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Outstanding - December 31, 2018</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,294,803</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.50</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1.7</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">&nbsp;Vested or expected to vest after December 31, 2018</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,953,264</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.50</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1.6</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">ESPP Activity and Expense</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 12pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">During the years ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">246,230</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">47,058</div> shares, respectively, of the Company's common stock were purchased under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> ESPP. At <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">382,824</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">80,594</div> shares, respectively, of the Company&#x2019;s common stock remained reserved for issuance under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> ESPP.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">During the years ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> the Company also recognized ESPP-related stock-based compensation expense of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.2</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.1</div> million, respectively.</div> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; margin: 0pt 0"></div></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; text-decoration: underline"><div style="display: inline; text-decoration: underline;">Year ended December 31,</div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 68%; text-align: left">Options granted</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,337,119</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">661,094</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Weighted-average grant-date fair value per share</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.18</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3.26</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Compensation expense related to stock options (in millions)</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2.6</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3.3</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Unrecognized compensation costs as of December 31 (in millions)</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8.5</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2.7</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> </table></div> 17800000 33000000 17800000 5700000 5700000 -1778000 5732000 5732000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13.</div> Divestiture</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 28, 2017, </div>the Company completed the sale of its subsidiary Amyris Brasil Ltda. (Amyris Brasil), which operated the Company&#x2019;s production facility located in Brotas, Brazil, to DSM and concurrently entered into a series of commercial agreements and a credit agreement with DSM. At closing, the Company received <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$33.0</div> million in contractual cash consideration for the capital stock of Amyris Brasil, which was subject to certain post-closing working capital adjustments; and reimbursements contingent upon DSM&#x2019;s utilization of certain Brazilian tax benefits it acquired with its purchase of Amyris Brasil. The Company used <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$12.6</div> million of the cash proceeds received to repay certain indebtedness of Amyris Brasil. The total fair value of the contractual consideration received by the Company for Amyris Brasil was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$56.9</div> million and resulted in a pretax gain of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.7</div> million from continuing operations. In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018, </div>the Company paid DSM <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.8</div> million related to the final post-closing working capital adjustment. In connection with the payment, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.8</div> million was recorded as a loss on divestiture in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> consolidated statement of operations, in the line captioned "(Loss) gain on divestiture".</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Concurrent with the sale of Amyris Brasil, the Company and DSM entered into a series of commercial agreements including (i) a license agreement to DSM of its farnesene product for DSM to use in the Vitamin E and lubricant markets; (ii) a royalty agreement, pursuant to which DSM agreed to pay the Company specified royalties representing a portion of the profit on the sale of Vitamin E produced from farnesene sold under the Nenter Supply Agreement assigned to DSM; (iii) a performance agreement for the Company to perform research and development to optimize farnesene for production and sale of farnesene products; and (iv) a transition services agreement for the Company to provide finance, legal, logistics, and human resource services to support the Brotas facility under DSM ownership for a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">six</div>-month period with a DSM option to extend for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">six</div> additional months (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> &#x201c;Revenue Recognition&#x201d; and Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> &#x201c;Subsequent Events&#x201d; for additional information). At closing, DSM paid the Company a nonrefundable license fee of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$27.5</div> million and a nonrefundable royalty payment of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$15.0</div> million. DSM also paid the Company a nonrefundable minimum annual royalty payment in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and will pay a nonrefundable minimum annual royalty payment in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019.</div> The future nonrefundable minimum annual royalty payments were determined to be fixed and determinable with a fair value of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$17.8</div> million and were included as part of the total arrangement consideration subject to allocation of this overall multiple-element divestiture transaction. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> &#x201c;Revenue Recognition&#x201d; and Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,</div> "Related Party Transactions" for a full listing and details of agreements entered into with DSM. Additionally, the Company and DSM entered into a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$25.0</div> million credit agreement that the Company used to repay all outstanding amounts under the Guanfu Note; see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> &#x201c;Debt&#x201d; for additional information.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company accounted for the sale of Amyris Brasil as a sale of a business for proceeds of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$54.8</div> million. The agreements entered into concurrently with the sale of Amyris Brasil including the license agreement, royalty agreement, performance agreement, transition services agreement, and credit agreement contain various elements and, as such, are deemed to be an arrangement with multiple deliverables as defined under U.S. GAAP. The Company performed an analysis to determine the fair value for all elements in the agreements with DSM and separated the elements between the non-revenue and revenue elements. After allocating the total fair value of the non-revenue elements from the fixed and determinable consideration received, the Company allocated the remaining fixed and determinable consideration to the revenue elements based on relative fair value. As such, the Company recognized <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$54.7</div> million of license revenue and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.1</div> million of deferred revenue related to the performance option and transition services agreements with DSM as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Results from the operations of Amyris Brasil are included in the Company's Consolidated Statements of Operations for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> and the Company has <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> segregated the results of operations or net assets of Amyris Brasil on the Company's consolidated financial statements for any period presented. The disposition of the assets and liabilities of Amyris Brasil did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> qualify for classification as a discontinued operation as it did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> represent a strategic shift that will have a major effect on the Company&#x2019;s operations and financial results.</div></div> 0 2828000 6100000 2100000 600000 23667000 20019000 20019000 18689000 46541000 46541000 -3.69 -6.26 -2.89 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font-size: 10pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8.</div> Net Loss per Share Attributable to Common Stockholders</div></div> <div style=" font-size: 10pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company computes net loss per share in accordance with ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">260,</div> &#x201c;Earnings per Share.&#x201d; Basic net loss per share of common stock is computed by dividing the Company&#x2019;s net loss attributable to Amyris, Inc. common stockholders by the weighted-average number of shares of common stock outstanding during the period. Diluted net loss per share of common stock is computed by giving effect to all potentially dilutive securities, including stock options, restricted stock units, convertible preferred stock, convertible promissory notes and common stock warrants, using the treasury stock method or the as converted method, as applicable. For the years ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> basic net loss per share was the same as diluted net loss per share because the inclusion of all potentially dilutive securities outstanding was anti-dilutive. As such, the numerator and the denominator used in computing both basic and diluted net loss were the same for those years.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company follows the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div>-class method when computing net loss per common share when shares are issued that meet the definition of participating securities. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div>-class method requires income available to common stockholders for the period to be allocated between common stock and participating securities based upon their respective rights to receive dividends as if all income for the period had been distributed. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div>-class method also requires losses for the period to be allocated between common stock and participating securities based on their respective rights if the participating security contractually participates in losses. The Company&#x2019;s convertible preferred stock are participating securities as they contractually entitle the holders of such shares to participate in dividends and contractually require the holders of such shares to participate in the Company&#x2019;s losses.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The following table presents the calculation of basic and diluted net loss per share of common stock attributable to Amyris, Inc. common stockholders:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-size: 10pt; font-weight: bold"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">Years Ended December 31, <br /> <div style="display: inline; text-decoration: underline;">(In thousands, except shares and per share amounts)</div></div></div></td> <td style="font-size: 10pt; font-weight: bold">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt; text-align: center"><div style="display: inline; font-weight: bold;">(As Restated, Note 2)</div></td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 72%; font-size: 10pt; text-align: left">Net loss attributable to Amyris, Inc.</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 11%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(230,235</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">)</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 11%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(155,982</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Less deemed dividend related to beneficial conversion feature on Series A preferred stock</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(562</div></td> <td style="font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Less deemed dividend related to beneficial conversion feature on Series B preferred stock</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(634</div></td> <td style="font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Less deemed dividend related to beneficial conversion feature on Series D preferred stock</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(5,757</div></td> <td style="font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Less deemed dividend upon settlement of make-whole provision on Series A preferred stock</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(10,505</div></td> <td style="font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Less deemed dividend upon settlement of make-whole provision on Series B preferred stock</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(22,632</div></td> <td style="font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Less deemed dividend related to the recognition of discounts on Series A preferred stock upon conversion</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(21,578</div></td> <td style="font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Less deemed dividend related to the recognition of discounts on Series B preferred stock upon conversion</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(24,366</div></td> <td style="font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Less deemed dividend related to proceeds discount upon conversion of Series D preferred stock</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,852</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Add: losses allocated to participating securities</td> <td style="font-size: 10pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,991</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">40,159</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Net loss attributable to Amyris, Inc. common stockholders</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(223,096</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(201,857</div></td> <td style="font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; font-style: italic">Denominator:</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Weighted-average shares of common stock outstanding used in computing net loss per share of common stock, basic and diluted</td> <td style="font-size: 10pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60,405,910</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">32,253,570</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Basic and diluted loss per share</td> <td style="font-size: 10pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3.69</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6.26</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">)</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The following outstanding shares of potentially dilutive securities were excluded from the computation of diluted net loss per share of common stock for the periods presented because including them would have been anti-dilutive:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-size: 10pt; font-weight: bold">Years Ended December 31,</td> <td style="font-size: 10pt; font-weight: bold">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; font-weight: bold">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; white-space: nowrap">(As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 72%; font-size: 10pt; text-align: left">Period-end common stock warrants</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 11%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,986,370</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 11%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29,921,844</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Convertible promissory notes (1)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,703,162</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,203,821</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Period-end stock options to purchase common stock</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,392,269</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,338,367</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Period-end restricted stock units</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,294,848</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">685,007</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Period-end preferred shares on an as-converted basis</td> <td style="font-size: 10pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,955,732</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,504,212</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Total potentially dilutive securities excluded from computation of diluted net loss per share</td> <td style="font-size: 10pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">53,332,381</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">44,653,251</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">______________</div> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; min-width: 700px;"> <tr style="vertical-align: top"> <td style="width: 0">&nbsp;</td> <td style="width: 14pt"><div style="display: inline; font-size: 10pt"><div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div>)</div></div></td> <td style="text-align: justify"><div style="display: inline; font-size: 10pt">The potentially dilutive effect of convertible promissory notes was computed based on conversion ratios in effect at the respective year-end. A portion of the convertible promissory notes issued carries a provision for a reduction in conversion price under certain circumstances, which could potentially increase the dilutive shares outstanding. Another portion of the convertible promissory notes issued carries a provision for an increase in the conversion rate under certain circumstances, which could also potentially increase the dilutive shares outstanding.</div></td> </tr> </table></div> -77000 186000 186000 0.047 0.21 0.34 0.155 -0.186 0.251 -0.001 -0.002 11000000 10600000 12400000 11900000 9220000 7238000 23800000 5000000 P3Y292D 8500000 2700000 0.5 0.5 12904000 7635000 2364000 3187000 40200000 33100000 27000000 2000000 27900000 3000000 1500000 3000000 64100000 13500000 40400000 7700000 3000000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; text-decoration: underline"><div style="display: inline; text-decoration: underline;">December 31,</div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Risk-free interest rate</td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2.5%</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">-</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3.0%</div></td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1.7%</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">-</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2.4%</div></td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Risk-adjusted discount yield</td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">17.2%</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">-</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">27.3%</div></td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18.4%</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">-</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28.5%</div></td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Stock price volatility</td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">45.0%</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">-</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">85.0%</div></td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">45.0%</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">-</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">80.0%</div></td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 76%; text-align: left">Probability of change in control</td> <td style="width: 1%">&nbsp;</td> <td style="width: 3%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="width: 5%; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">0.0%</div></td> <td style="white-space: nowrap; width: 3%; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="width: 1%">&nbsp;</td> <td style="width: 3%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="width: 5%; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.0%</div></td> <td style="white-space: nowrap; width: 3%; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Stock price</td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.34</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.75</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Credit spread</td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">14.6%</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">-</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24.9%</div></td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16.6%</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">-</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">26.7%</div></td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Estimated conversion dates</td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">-</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2025</div></td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">-</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2025</div></td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; text-decoration: underline"><div style="display: inline; text-decoration: underline;">In thousands</div></td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 86%">Fair value at issuance on December 10, 2018</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60,000</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Change in fair value</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,082</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Fair value at December 31, 2018</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.25pt double; text-align: left">$</td> <td style="border-bottom: Black 2.25pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,918</div></td> <td style="white-space: nowrap; border-bottom: Black 2.25pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Fair Value Measurements</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The carrying amounts of certain financial instruments, such as cash equivalents, short-term investments, accounts receivable, accounts payable and accrued liabilities, approximate fair value due to their relatively short maturities.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The Company measures the following financial assets and liabilities at fair value:</div> <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; min-width: 700px;" cellspacing="0" cellpadding="0"> <tr style="vertical-align: top"> <td style="width: 27pt"></td> <td style="width: 18pt">&#x2022;</td> <td>Freestanding and bifurcated derivatives in connection with certain debt and equity financings; and</td> </tr> </table> <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; min-width: 700px;" cellspacing="0" cellpadding="0"> <tr style="vertical-align: top"> <td style="width: 27pt"></td> <td style="width: 18pt">&#x2022;</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,</div> "Fair Value Measurement", Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> "Debt" and Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> &#x201c;Subsequent Events&#x201d;), for which the Company has elected fair value accounting</td> </tr> </table> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Fair value is based on the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants. Where available, fair value is based on or derived from observable market prices or other observable inputs. Where observable prices or inputs are <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> available, valuation techniques are applied. These valuation techniques involve some level of management estimation and judgement, the degree of which is dependent on the price transparency for the instruments or market and the instruments&#x2019; complexity.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Changes to the inputs used in these valuation models have a significant impact on the estimated fair value of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> and the Company's embedded and freestanding derivatives. For example, a decrease (increase) in the estimated credit spread for the Company results in an increase (decrease) in estimated fair value. Conversely, a decrease (increase) in the stock price results in a decrease (increase) in estimated fair value.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The changes during <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div> in the fair values of the bifurcated compound embedded derivatives are primarily related to the change in price of the Company's common stock and are reflected in the consolidated statements of operations as &#x201c;Gain (loss) from change in fair value of derivative instruments&#x201d;.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">For debt instruments for which the Company has <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> elected fair value accounting, fair value is based on the present value of expected future cash flows and assumptions about the then-current market interest rates as of the reporting period and the creditworthiness of the Company. Most of the Company's debt is carried on the consolidated balance sheet on a historical cost basis net of unamortized discounts and premiums, because the Company has <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> elected the fair value option of accounting. However, for the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021,</div> the Company elected fair value accounting, so that balances reported for that debt instrument represent fair value as of each balance sheet date; see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,</div> "Fair Value Measurement", for additional information. Changes in fair value of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> are reflected in the consolidated statements of operations as &#x201c;Gain (loss) from change in fair value of debt&#x201d;.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">For all debt instruments, including any for which the Company has elected fair value accounting, the Company classifies interest that has been accrued during each period as Interest expense on the consolidated statements of operations.</div></div></div></div></div></div></div></div></div></div></div></div> 2082000 -30880000 -48852000 4089000 133517000 108670000 70007000 60000000 57918000 116497000 4135000 42796000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; text-decoration: underline"><div style="display: inline; text-decoration: underline;">(in thousands)</div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center">(As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 72%">Balance at January 1</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">116,497</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,135</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-indent: 10pt">Additions</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,089</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">133,517</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-indent: 10pt">Loss from change in fair value of derivative liabilities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">30,880</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">48,852</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-indent: 10pt">Derecognition to additional paid-in capital upon conversion or extinguishment</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(108,670</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(70,007</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Balance at December 31</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,796</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">116,497</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.</div> Fair Value Measurement</div></div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0">Assets and liabilities are measured and reported at fair value per related accounting standards that define fair value as the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. The fair value hierarchy prioritizes the inputs to valuation techniques used to measure fair value. An asset's or liability's level is based on the lowest level of input that is significant to the fair value measurement. Assets and liabilities carried at fair value are valued and disclosed in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> of the following <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> levels of the valuation hierarchy:</div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-indent: 13.5pt; margin: 0pt 0 0pt 9pt">&#x2022; <div style="display: inline; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp; </div>Level <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1:</div> Quoted market prices in active markets for identical assets or liabilities.</div> <div style=" font-size: 10pt; text-indent: 13.5pt; margin: 0pt 0 0pt 9pt">&#x2022; <div style="display: inline; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp; </div>Level <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2:</div> Observable market-based inputs or unobservable inputs that are corroborated by market data.</div> <div style=" font-size: 10pt; text-indent: 13.5pt; margin: 0pt 0 0pt 9pt">&#x2022; <div style="display: inline; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp; </div>Level <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3:</div> Unobservable inputs that are <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> corroborated by market data.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Assets and Liabilities Measured and Recorded at Fair Value on a Recurring Basis</div></div></div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> the Company&#x2019;s financial assets and financial liabilities measured at fair value on a recurring basis were classified within the fair value hierarchy as follows:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">December 31,<br /> (In thousands)</td> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="15" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="15" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017 (As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom"> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Level&nbsp;1</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Level 2</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Level&nbsp;3</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total</td> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Level&nbsp;1</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Level 2</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Level&nbsp;3</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; font-weight: bold">Assets</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; width: 36%">Money market funds</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 5%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 5%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 5%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 5%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 5%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">53,199</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 5%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 5%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 5%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">53,199</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; padding-bottom: 1pt">Certificates of deposit</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,153</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,153</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Total assets measured and recorded at fair value</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">53,199</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,153</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,352</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; font-weight: bold">Liabilities</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">6% Convertible Notes Due 2021</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,918</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,918</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Embedded derivatives in connection with the issuance of debt and equity instruments</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">723</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">723</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt">Freestanding derivative instruments in connection with the issuance of equity instruments</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,796</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,796</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">115,774</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">115,774</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-bottom: 2.5pt; text-indent: 10pt">Total liabilities measured and recorded at fair value</td> <td style="font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100,714</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100,714</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">116,497</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">116,497</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">There were <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> transfers between the levels during <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> or <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">The Company&#x2019;s assessment of the significance of a particular input to the fair value measurement in its entirety requires management to make judgements and consider factors specific to the asset or liability. The fair values of money market funds and certificates of deposit are based on fair values of identical assets. The method of determining the fair value of compound embedded derivative liabilities is described subsequently in this note. Market risk associated with compound embedded derivative liabilities relates to the potential reduction in fair value and negative impact to future earnings from a decrease in interest rates.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">At <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> the carrying value of certain financial instruments, such as cash equivalents, accounts receivable, prepaid expenses and other current assets, accounts payable and other current accrued liabilities, approximate fair value due to their relatively short maturities and low market interest rates, if applicable.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">Changes in fair value of derivative liabilities are presented as gains or losses in the consolidated statements of operations in the line captioned "Gain (loss) from change in fair value of derivative instruments".</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">Changes in the fair value of debt that is accounted for at fair value are presented as gains or losses in the consolidated statements of operations in the line captioned "Gain (loss) from change in fair value of debt".</div> <div style=" font-size: 10pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">The Company issued <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$60.0</div> million of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 10, 2018 (</div>see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> "Debt" and &#x201c;Subsequent Events&#x201d; for details) and elected the fair value option of accounting for this instrument. At <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> outstanding principal was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$60.0</div> million, and the fair value was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$57.9</div> million, which was measured using a binomial lattice model and assuming a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25.2%</div> discount yield, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">45%</div> equity volatility, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50%</div> / <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50%</div> probability of principal repayment in cash / stock, and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5%</div> probability of change in control. The Company assumed that if a change of control event were to occur, it would occur at the end of the calendar year. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> &#x201c;Debt&#x201d; and Part II, Item <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,</div> &#x201c;Subsequent Events&#x201d; for further information related to this debt instrument. For the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> the Company recorded a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.1</div> million gain from change in fair value of debt in connection with the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021,</div> as follows:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; text-decoration: underline"><div style="display: inline; text-decoration: underline;">In thousands</div></td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 86%">Fair value at issuance on December 10, 2018</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60,000</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Change in fair value</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,082</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Fair value at December 31, 2018</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.25pt double; text-align: left">$</td> <td style="border-bottom: Black 2.25pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,918</div></td> <td style="white-space: nowrap; border-bottom: Black 2.25pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Derivative Instruments</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 12pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">Derivative instruments measured at fair value on a recurring basis as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div> are as follows:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">December 31, </div></div><br /> <div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; text-decoration: underline;">(In thousands)</div></div></div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; text-align: center">&nbsp;</td> <td style="font-weight: bold; text-align: center">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center">&nbsp;</td> <td style="font-weight: bold; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center">(As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 66%; text-align: left">Equity-related derivative liabilities</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">41,272</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">108,887</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Debt-related derivative liabilities</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,524</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,610</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Total derivative liabilities</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,796</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">116,497</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">The following table provides a reconciliation of the beginning and ending liability balances associated with derivative liabilities &#x2013; either freestanding or compound embedded &#x2013; measured at fair value using significant unobservable inputs (Level <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div>):</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">&nbsp;</div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; text-decoration: underline"><div style="display: inline; text-decoration: underline;">(in thousands)</div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center">(As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 72%">Balance at January 1</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">116,497</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,135</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-indent: 10pt">Additions</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,089</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">133,517</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-indent: 10pt">Loss from change in fair value of derivative liabilities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">30,880</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">48,852</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-indent: 10pt">Derecognition to additional paid-in capital upon conversion or extinguishment</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(108,670</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(70,007</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Balance at December 31</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,796</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">116,497</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">The liabilities associated with freestanding and compound embedded derivatives represent the fair value of the equity conversion options, make-whole provisions, down round conversion price or conversion rate adjustment provisions and antidilution provisions in some of the Company's debt, preferred stock, cash warrants and antidilution warrants; see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> "Debt", and Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,</div> "Stockholders' Deficit". There is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> current observable market for these types of derivatives and, as such, the Company determined the fair value of the freestanding or embedded derivatives using the Monte Carlo or binomial lattice models.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">A binomial lattice model was used to determine if a convertible note or share of convertible preferred stock would be converted, called or held at each decision point. Within the lattice model, the following assumptions are made: (i) the convertible note or share of convertible preferred stock will be converted early if the conversion value is greater than the holding value and (ii) the convertible note or share of convertible preferred stock will be called if the holding value is greater than both (a) redemption price and (b) the conversion value at the time. If the convertible note or share of convertible preferred stock is called, the holder will maximize their value by finding the optimal decision between (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div>) redeeming at the redemption price and (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div>) converting the convertible note or share of convertible preferred stock. Using this lattice method, the Company valued the embedded and freestanding derivatives using the "with-and-without method", where the fair value of each related convertible note or share of convertible preferred stock including the embedded derivative is defined as the "with", and the fair value of the convertible note excluding the embedded derivatives is defined as the "without". This method estimates the fair value of the embedded and freestanding derivatives by looking at the difference in the values between each convertible note or share of convertible preferred stock with the embedded and freestanding derivatives and the fair value of such convertible note or share of convertible preferred stock without the embedded and freestanding derivatives. The lattice model uses the stock price, conversion price, maturity date, risk-free interest rate, estimated stock volatility and estimated credit spread. The Company marks the compound embedded derivatives to market due to the conversion price <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> being indexed to the Company's own stock.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">The Company used a Monte Carlo simulation valuation model to determine the fair value of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Cash and Dilution Warrants. Monte Carlo simulation combines a random number generator based on a probability distribution and additional inputs of volatility, time to expiration to generate a stock price and other uncertainties. The generated stock price at the time of expiration is then used to calculate the value of the option. The model then calculates results tens of thousands of times, each time using a different set of random values from the probability functions. The resulting Monte Carlo simulation valuation is based on the average of all the calculated results.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">The market-based assumptions and estimates used in valuing the compound embedded and freestanding derivative liabilities include amounts in the following ranges/amounts:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; text-decoration: underline"><div style="display: inline; text-decoration: underline;">December 31,</div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Risk-free interest rate</td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2.5%</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">-</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3.0%</div></td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1.7%</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">-</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2.4%</div></td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Risk-adjusted discount yield</td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">17.2%</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">-</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">27.3%</div></td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18.4%</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">-</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28.5%</div></td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Stock price volatility</td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">45.0%</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">-</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">85.0%</div></td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">45.0%</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">-</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">80.0%</div></td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 76%; text-align: left">Probability of change in control</td> <td style="width: 1%">&nbsp;</td> <td style="width: 3%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="width: 5%; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">0.0%</div></td> <td style="white-space: nowrap; width: 3%; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="width: 1%">&nbsp;</td> <td style="width: 3%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="width: 5%; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.0%</div></td> <td style="white-space: nowrap; width: 3%; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Stock price</td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.34</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.75</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Credit spread</td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">14.6%</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">-</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24.9%</div></td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16.6%</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">-</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">26.7%</div></td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Estimated conversion dates</td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">-</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2025</div></td> <td>&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div></td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">-</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2025</div></td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">Changes in valuation assumptions can have a significant impact on the valuation of the embedded and freestanding derivative liabilities and debt that the Company elects to account for at fair value. For example, all other things being equal, a decrease/increase in the Company&#x2019;s stock price, probability of change of control, credit spread, term to maturity/conversion or stock price volatility decreases/increases the valuation of the liabilities, whereas a decrease/increase in risk adjusted yields or risk-free interest rates increases/decreases the valuation of the liabilities. Certain of the convertible notes, shares of convertible preferred stock and warrants also include conversion or exercise price adjustment features and, for example, certain issuances of common stock by the Company at prices lower than the current conversion or exercise price result in a reduction of the conversion price of such notes or convertible preferred stock, or a reduction in the exercise price of, or an increase in the number of shares subject to, such warrants, which increases the value of the embedded and freestanding derivative liabilities and debt measured at fair value; see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> "Debt" for details.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">The Series A Preferred Stock issued in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>and Series B Preferred Stock issued in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 (</div>see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,</div> &#x201c;Stockholder&#x2019;s Deficit&#x201d;) included make-whole provisions, which are accounted for as embedded derivatives through the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2017 </div>Shareholder Approval date at which time the make-whole provision became settleable for a fixed number of common stock shares and ceased to be accounted for as a derivative liability. Cash and antidilution warrants, classified as freestanding financial instruments, were also issued in conjunction with the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Offering, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Offering and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Offering and are classified as derivative liabilities. The total derivative liability recorded for the securities issued in connection with the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Offering, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Offering and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Offering was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$113.1</div> million.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 2012, </div>the Company entered into a cross-currency interest rate swap arrangement with Banco Pine with respect to the repayment of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">R$22.0</div> million (approximately U.S. <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.6</div> million based on the exchange rate as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div>) of the Banco Pine Note. The swap arrangement exchanged the principal and interest payments under the Banco Pine Note (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,</div> "Debt") for alternative principal and interest payments that are subject to adjustment based on fluctuations in the foreign currency exchange rate between the U.S. dollar and Brazilian real. The swap had a fixed interest rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3.94%.</div> Changes in the fair value of the swap were recognized in the consolidated statements of operations, in &#x201c;Gain (loss) from change in fair value of derivative instruments". As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> the balances of the loan and the associated cross-currency interest rate swap were zero.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Assets and Liabilities Recorded at Carrying Value</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Financial Assets and Liabilities</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The carrying amounts of certain financial instruments, such as cash equivalents, accounts receivable, accounts payable and accrued liabilities, approximate fair value due to their relatively short maturities and low market interest rates, if applicable. Loans payable, credit facilities and convertible notes are recorded at carrying value (except for the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021,</div> which are recorded at fair value), which is representative of fair value at the date of acquisition. For loans payable and credit facilities recorded at carrying value, the Company estimates fair value using observable market-based inputs (Level <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div>); for convertible notes, the Company estimates fair value based on rates currently offered for instruments with similar maturities and terms (Level <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div>). The carrying amount (the total amount of net debt presented on the balance sheet) of the Company's debt at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> excluding the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes that the Company records at fair value, and at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$151.7</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$165.4</div> million, respectively. The fair value of such debt at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div> was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$149.3</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$156.9</div> million, respectively, and was determined by (i) discounting expected cash flows using current market discount rates estimated for certain of the debt instruments and (ii) using <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">third</div>-party fair value estimates for the remaining debt instruments.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"><div style="display: inline; font-weight: bold;"></div></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Assets and Liabilities Measured and Recorded at Fair Value on a Non-Recurring Basis</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 19, 2018, </div>the Company amended its supply agreement with DSM, as discussed in Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> &#x201c;Revenue Recognition&#x201d; to secure production capacity at the Brotas facility in exchange for future cash payments totaling <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$22.7</div> million, the issuance of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,643,991</div> million shares common stock valued at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.1</div> million on the date of issuance and a further cash payment for the difference between the fair value of the common stock and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$7.3</div> million on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 29, 2019. </div>In addition, the Company modified certain warrants held by DSM which resulted in the transfer of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.9</div> million of value to DSM and paid <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.8</div> million to settle certain obligations to DSM related to the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div> sale of the Brotas facility. The Company also entered into other transactions contemporaneously with the amended supply agreement as discussed in Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,</div> &#x201c;Related Party Transactions&#x201d; and Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> &#x201c;Subsequent Events&#x201d;. This series of transactions with DSM in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018 </div>was accounted for as a combined transaction in which the Company determined and allocated the fair value of the consideration to each element. The fair value of the consideration transferred to DSM under the combined arrangement totaled <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$33.3</div> million and was allocated as follows (in thousands):</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold; border-bottom: Black 1pt solid">Element</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Fair Value Allocation</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 77%; text-align: left">Manufacturing capacity reservation fee</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 20%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,395</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Legal settlement and consent waiver</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,764</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Working capital adjustment</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,145</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Total fair value of consideration transferred</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">33,304</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The fair value of these elements is based on Level <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div> inputs, which considered the lowest level of input that is significant to the fair value measurement of these elements. To determine the fair value of the manufacturing capacity reservation fee, the Company used a discounted cash flow model under a cost savings valuation approach based on a competing manufacturing quote for similar capacity, location and timing. The Company used a discount rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">22.5%</div> and a tax rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">0%</div> to discount the gross cash flows. The fair value of the legal settlement for failure to obtain consent from DSM prior to executing the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2018 </div>Vivo Warrant transaction and was determined by calculating the difference between the fair values of the warrants held by Vivo prior to and after the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2018 </div>Vivo Warrant transaction using a combination of a Monte Carlo simulation and the Black-Scholes-Merton option pricing model. The fair value of the working capital adjustment was determined to equal the difference between the preliminary estimate for working capital upon closing the Brotas facility sale and the final working capital amounts transferred.</div></div> 1600000 400000 2223000 1230000 1230000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Foreign Currency Translation</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The assets and liabilities of foreign subsidiaries, where the local currency is the functional currency, are translated from their respective functional currencies into U.S. dollars at the rates in effect at each balance sheet date, and revenue and expense amounts are translated at average rates during each period, with resulting foreign currency translation adjustments recorded in other comprehensive loss, net of tax, in the consolidated statements of stockholders&#x2019; deficit. As of&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>&nbsp;and&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> cumulative translation adjustment, net of tax, were <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$43.3</div> million&nbsp;and&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$42.2</div> million, respectively.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Where the U.S. dollar is the functional currency, remeasurement adjustments are recorded in other income (expense), net in the accompanying consolidated statements of operations. Net losses resulting from foreign exchange transactions were&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.6</div> million and&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.4</div> million&nbsp;for the years ended&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> respectively and are recorded in other income (expense), net in the consolidated statements of operations.</div></div></div></div></div></div></div></div></div></div></div></div> -4000000 -30880000 -48852000 -1742000 -47110000 900000 100000 -941000 -142000 -142000 100000 2000000 -1800000 -10900000 -6500000 10900000 6500000 -1900000 -17424000 -11897000 -1521000 -10376000 3865000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Impairment</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Long-lived assets that are held and used by the Company are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount of such assets <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> be recoverable. Determination of recoverability of long-lived assets is based on an estimate of the undiscounted future cash flows resulting from the use of the asset and its eventual disposition. Measurement of an impairment loss for long-lived assets that management expects to hold and use is based on the difference between the fair value of the asset and its carrying value. Long-lived assets to be disposed of are reported at the lower of carrying amount or fair value less costs to sell.</div></div></div></div></div></div></div></div></div></div></div></div> -218109000 -156020000 -230234000 -149105000 -12125000 6915000 -230235000 -149105000 -72034000 -77071000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">14.</div> Income Taxes</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The components of loss before income taxes are as follows:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">Years Ended December 31, <br /> <div style="display: inline; text-decoration: underline;">(In thousands)</div></div></div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center">(As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 68%; text-align: left">United States</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(218,109</div></td> <td style="width: 1%; text-align: left">)</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(156,020</div></td> <td style="width: 1%; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Foreign</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(12,125</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,915</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Loss before income taxes</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(230,234</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">)</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(149,105</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">)</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The components of the provision for income taxes are as follows:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">Years Ended December 31, <br /> <div style="display: inline; text-decoration: underline;">(In thousands)</div></div></div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td style="font-weight: bold; text-align: left">&nbsp;</td> <td style="font-weight: bold; text-align: right; white-space: nowrap"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">(As Restated, Note 2)</div></div></td> <td style="font-weight: bold; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Current:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 68%">Federal</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,564</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>State</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Foreign</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">964</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Total current provision</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,546</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Deferred:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Federal</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(669</div></td> <td style="text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>State</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Foreign</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Total deferred benefit</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(669</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Total provision for income taxes$</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,877</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">A reconciliation between the statutory federal income tax and the Company&#x2019;s effective tax rates as a percentage of loss before income taxes is as follows:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold; text-decoration: underline"><div style="display: inline; text-decoration: underline;">Years Ended December 31,</div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center">(As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 68%; text-align: left">Statutory tax rate</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(21.0</div></td> <td style="width: 1%; text-align: left">)%</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(34.0</div></td> <td style="width: 1%; text-align: left">)%</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">State taxes, net of federal tax benefit</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Stock-based compensation</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Federal R&amp;D credit</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(0.6</div></td> <td style="text-align: left">)%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(0.2</div></td> <td style="text-align: left">)%</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Derivative liability</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.3</div></td> <td style="text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13.9</div></td> <td style="text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Nondeductible interest</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1.0</div></td> <td style="text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3.0</div></td> <td style="text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Other</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(0.1</div></td> <td style="text-align: left">)%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(0.2</div></td> <td style="text-align: left">)%</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Foreign losses</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">0.9</div></td> <td style="text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8.5</div></td> <td style="text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Change in U.S. federal tax rate</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25.1</div></td> <td style="text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">IRC Section 382 limitation</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7.2</div></td> <td style="text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Change in valuation allowance</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15.5</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">%</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(18.6</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)%</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Effective income tax rate</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">%</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.7</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">%</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</div> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Temporary differences and carryforwards that gave rise to significant portions of deferred taxes are as follows:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">December 31, <br /> <div style="display: inline; text-decoration: underline;">(In thousands)</div></div></div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td style="white-space: nowrap">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center">(As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 72%; text-align: left">Net operating loss carryforwards</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,921</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">20,066</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Property, plant and equipment</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,269</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,653</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Research and development credits</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,046</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,480</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Foreign tax credit</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Accruals and reserves</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,526</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,286</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Stock-based compensation</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,496</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,471</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Disallowed interest carryforward</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,359</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Capitalized start-up costs</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Capitalized research and development costs</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">27,888</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">32,085</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Intangible and others</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,114</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,584</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Equity investments</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">156</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Total deferred tax assets</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">127,775</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">87,625</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Debt discount and derivatives</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,750</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,539</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Total deferred tax liabilities</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,750</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,539</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Net deferred tax assets prior to valuation allowance</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">124,025</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">81,086</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Less: valuation allowance</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(124,025</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(81,086</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Net deferred tax assets</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Activity in the deferred tax assets valuation allowance is summarized as follows:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; text-decoration: underline"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Balance at Beginning <br /> of Year</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Additions</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Reductions / <br /> Charges</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Balance at <br /> End of Year</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Deferred tax assets valuation allowance:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 44%">Year Ended December 31, 2018</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">81,086</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,939</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">124,025</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Year Ended December 31, 2017 (As Restated, Note 2)</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">386,867</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(305,781</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">81,086</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Recognition of deferred tax assets is appropriate when realization of such assets is more likely than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not.</div> Based on the weight of available evidence, especially the uncertainties surrounding the realization of deferred tax assets through future taxable income, the Company believes that it is more likely than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> that the net deferred tax assets will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> be fully realizable. Accordingly, the Company has provided a full valuation allowance against its net deferred tax assets as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017.</div> The valuation allowance decreased by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$305.8</div> million during the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017 </div>and increased by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$42.9</div> million during the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018. </div>The valuation allowance decreased by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$305.8</div> million during the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017 </div>due to the partial write-off of federal net operating loss (NOL) carryforwards due to the IRC Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">382</div> limitation further described below and due to tax reform that changed deferred tax asset rate from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">35%</div> down to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">21%.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 22, 2017, </div>the U.S. government enacted comprehensive tax legislation, commonly referred to as the Tax Cuts and Jobs Act (Tax Act). The Tax Act makes broad and complex changes to the U.S. tax code, including, but <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> limited to, (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div>) reducing the U.S. federal corporate tax rate from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">35</div> percent to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">21</div> percent; (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div>) requiring companies to pay a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div>-time transition tax on certain unrepatriated earnings of foreign subsidiaries; (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div>) generally eliminating U.S. federal income taxes on dividends from foreign subsidiaries; (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4</div>) requiring a current inclusion in U.S. federal taxable income of certain earnings of controlled foreign corporations; (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5</div>) eliminating the corporate alternative minimum tax (AMT) and changing how existing AMT credits can be realized; (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6</div>) creating the base erosion anti-abuse tax, a new minimum tax; (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7</div>) creating a new limitation on deductible interest expense; and (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8</div>) changing the rules related to uses and limitations of NOL carryforwards created in tax years beginning after <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 22, 2017, </div>Staff Accounting Bulletin <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">No.</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">118</div> (SAB <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">118</div>) was issued to address the application of GAAP in situations when a registrant does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> have the necessary information available, prepared or analyzed (including computations) in reasonable detail to complete the accounting for certain income tax effects of the Tax Act. In accordance with SAB <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">118,</div> the Company recorded a provisional amount related to the remeasurement of certain deferred tax assets and liabilities based on the rates at which they are expected to reverse in the future, which resulted in a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$37.7</div> million net decrease related to deferred tax assets and deferred tax liabilities, with a corresponding and fully offsetting adjustment to our valuation allowance for the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017. </div>As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 22, 2018, </div>the Company completed its accounting for the remeasurement of certain deferred tax assets and liabilities based on the rates at which they are expected to reverse in the future. There have been <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> net benefit changes to the provisional estimates disclosed in the period of enactment under SAB <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">118.</div> The Tax Act also created a new requirement that certain income (i.e., GILTI) earned by controlled foreign corporations (CFCs) must be included currently in the gross income of the CFCs' U.S. shareholder. The Company has elected to treat GILTI as a period cost in its income tax provision computations.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018, </div>the Company had federal net operating loss carryforwards of approximately <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$290.7</div> million and state net operating loss carryforwards <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$154.3</div> million, available to reduce future taxable income, if any. The Internal Revenue Code of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1986,</div> as amended, imposes restrictions on the utilization of net operating losses in the event of an &#x201c;ownership change&#x201d; of a corporation. Accordingly, a company&#x2019;s ability to use net operating losses <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be limited as prescribed under Internal Revenue Code Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">382</div> (IRC Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">382</div>). Events that <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>cause limitations in the amount of the net operating losses that the Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>use in any <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> year include, but are <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> limited to, a cumulative ownership change of more than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50%</div> over a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div>-year period. During the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017, </div>the Company experienced a cumulative ownership change of greater than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50%.</div> As such, net operating losses generated prior to that change are subject to an annual limitation on their use. Due to the limitations imposed, the Company wrote-off <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$456.2</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$115.5</div> million of federal NOL and state NOL carryovers that are expected to expire before they can be utilized. Additionally, the Company wrote-off <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$14.7</div> million of its historical federal research and development credit carryovers as a result of the limitations. As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018, </div>the Company had foreign net operating loss carryovers of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$7.3</div> million.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018, </div>the Company had federal research and development credit carryforwards of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.6</div> million and California research and development credit carryforwards of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$13.5</div> million.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">If <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> utilized, the federal net operating loss carryforward will begin expiring in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2025,</div> and the California net operating loss carryforward will begin expiring in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2028.</div> The federal research and development credit carryforwards will expire starting in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2038</div> if <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> utilized. The California research and development credit carryforwards can be carried forward indefinitely.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">A reconciliation of the beginning and ending amounts of unrecognized tax benefits is as follows:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; text-decoration: underline"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 84%">Balance at December&nbsp;31, 2016</td> <td style="width: 1%">&nbsp;</td> <td style="text-align: left; width: 1%">$</td> <td style="text-align: right; width: 13%"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,101</div></td> <td style="white-space: nowrap; text-align: left; width: 1%">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Increases in tax positions for prior period</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Increases in tax positions during current period</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19,682</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Balance at December&nbsp;31, 2017</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28,833</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Increases in tax positions for prior period</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">55</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Increases in tax positions during current period</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,239</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Balance at December&nbsp;31, 2018</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">30,127</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company&#x2019;s policy is to include interest and penalties related to unrecognized tax benefits within the provision for taxes. The Company determined that accrual for interest and penalties was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> material as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018 </div>or <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">None</div> of the unrecognized tax benefits, if recognized, would affect the effective income tax rate for any of the above years due to the valuation allowance that currently offsets deferred tax assets. The Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> anticipate that the total amount of unrecognized income tax benefits will significantly increase or decrease in the next <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12</div> months.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company&#x2019;s primary tax jurisdiction is the United States. For United States federal and state tax purposes, returns for tax years <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2005</div> and forward remain open and subject to tax examination by the appropriate federal or state taxing authorities. Brazil tax years <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> and forward remain open and subject to examination.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018, </div>the U.S. Internal Revenue Service (the IRS) has completed its audit of the Company for tax year <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2008</div> and concluded that there were <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> adjustments resulting from the audit. While the statutes are closed for tax year <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2008,</div> the U.S. federal tax carryforwards (net operating losses and tax credits) <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be adjusted by the IRS in the year in which the carryforward is utilized.</div></div> 6877000 295000 6582000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Income Taxes</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The Company is subject to income taxes in the United States and foreign jurisdictions and uses estimates to determine its provisions for income taxes. The Company uses the asset and liability method of accounting for income taxes, whereby deferred tax asset or liability account balances are calculated at the balance sheet date using current tax laws and rates in effect for the year in which the differences are expected to affect taxable income.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> </div> <!-- Field: Page; Sequence: 22 --> <!-- Field: /Page --> <div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Recognition of deferred tax assets is appropriate when realization of such assets is more likely than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not.</div> The Company recognizes a valuation allowance against its net deferred tax assets unless it is more likely than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> that such deferred tax assets will be realized. This assessment requires judgement as to the likelihood and amounts of future taxable income by tax jurisdiction.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The Company applies the provisions of Financial Accounting Standards Board (FASB) guidance on accounting for uncertainty in income taxes. The Company assesses all material positions taken in any income tax return, including all significant uncertain positions, in all tax years that are still subject to assessment or challenge by relevant taxing authorities. Assessing an uncertain tax position begins with the initial determination of the position&#x2019;s sustainability, and the tax benefit to be recognized is measured at the largest amount of benefit that is greater than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50</div>&nbsp;percent likely of being realized upon ultimate settlement. As of each balance sheet date, unresolved uncertain tax positions must be reassessed, and the Company will determine whether (i)&nbsp;the factors underlying the sustainability assertion have changed and (ii)&nbsp;the amount of the recognized tax benefit is still appropriate. The recognition and measurement of tax benefits requires significant judgement, and such judgements <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>change as new information becomes available.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div></div></div></div></div></div></div></div></div></div></div></div></div> 4286000 8150000 11603000 5452000 5858000 -406000 -7448000 19647000 19647000 8461000 13877000 7295000 6582000 -8056000 7940000 7940000 3900000 3158000 -7241000 -7241000 -41000000 14000000 4416000 3126000 3126000 13100000 865000 -865000 7000000 7000000 42703000 37081000 34033000 3048000 18524000 11539000 11539000 3853000 8213000 5253000 4225000 9693000 5408000 5408000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Inventories</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Inventories, which consist of farnesene-derived products, flavors and fragrances ingredients and clean beauty products, are stated at the lower of actual cost or net realizable value and are categorized as finished goods, work in process or raw material inventories. The Company evaluates the recoverability of its inventories based on assumptions about expected demand and net realizable value. If the Company determines that the cost of inventories exceeds their estimated net realizable value, the Company records a write-down equal to the difference between the cost of inventories and the estimated net realizable value. If actual net realizable values are less favorable than those projected by management, additional inventory write-downs <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be required that could negatively impact the Company's operating results. If actual net realizable values are more favorable, the Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>have favorable operating results when products that have been previously written down are sold in the normal course of business. The Company also evaluates the terms of its agreements with its suppliers and establishes accruals for estimated losses on adverse purchase commitments as necessary, applying the same lower of cost or net realizable value approach that is used to value inventory. Cost is computed on a weighted-average basis.</div></div></div></div></div></div></div></div></div></div></div></div> 3901000 819000 5800000 5100000 6800000 1000000 24900000 339744000 352884000 346190000 6694000 127925000 140796000 151483000 -10687000 211736000 105968000 107146000 -1178000 100714000 100714000 116497000 116497000 0 0 8000000 8000000 35000000 31000000 25000000 25000000 25000000 25000000 8000000 8500000 16000000 19000000 8000000 12500000 209697000 8000000 15200000 9800000 5000000 57918000 35474000 28429000 23137000 20834000 4345000 1883000 4975000 120874000 56121000 23667000 20921000 22608000 3682000 23667000 47211000 34651000 7953000 7138000 3863000 5186000 28313000 381000 46467000 41018000 18689000 16961000 2000000 393000 18689000 19354000 163704000 9283000 8167000 22608000 3682000 9283000 34457000 18689000 16961000 393000 18689000 17354000 2000000 4819000 4340000 9565000 8409000 42356000 66560000 124010000 36924000 36924000 57918000 0 57900000 57918000 57918000 0.252 0.45 0.5 0.5 43331000 60220000 61893000 -1673000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9.</div> Commitments and Contingencies</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Lease Obligations</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company leases certain facilities and finances certain equipment under operating and capital leases, respectively. Operating leases include leased facilities, and capital leases include leased equipment (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,</div> "Balance Sheet Details"). The Company recognizes rent expense on a straight-line basis over the noncancelable lease term and records the difference between cash rent payments and the recognition of rent expense as a deferred rent liability. Where leases contain escalation clauses, rent abatements, and/or concessions, such as rent holidays and landlord or tenant incentives or allowances, the Company applies them as straight-line rent expense over the lease term. The Company has noncancelable operating lease agreements for office, research and development, and manufacturing space that expire at various dates, with the latest expiration in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2023. </div>Rent expense under operating leases was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.8</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.1</div> million for the years ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> respectively.</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Future minimum payments under the Company's lease obligations as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> are as follows:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; text-align: left"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">Years Ending December&nbsp;31 </div></div><br /> <div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; text-decoration: underline;">(In thousands)</div></div></div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Capital <br /> Leases</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Operating <br /> Leases</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total Lease <br /> Obligations</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 55%; text-align: left">2019</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">513</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,416</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,929</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2020</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">198</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,932</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,130</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">2021</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,226</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,227</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2022</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,399</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,399</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">2023</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,034</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,034</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Thereafter</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Total future minimum payments</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">712</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">36,007</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">36,719</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Less: amount representing interest</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(33</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Present value of minimum lease payments</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">679</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Less: current portion</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(484</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Long-term portion</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">195</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 12pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Guarantor Arrangements</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company has agreements whereby it indemnifies its executive officers and directors for certain events or occurrences while the executive officer or director is serving in his or her official capacity. The indemnification period remains enforceable for the executive officer's or director&#x2019;s lifetime. The maximum potential amount of future payments the Company could be required to make under these indemnification agreements is unlimited; however, the Company has a director and officer insurance policy that limits its exposure and enables the Company to recover a portion of any future payments. As a result of its insurance policy coverage, the Company believes the estimated fair value of these indemnification agreements is minimal. Accordingly, the Company had <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> liabilities recorded for these agreements as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The GACP Term Loan Facility (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> "Debt" and Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> &#x201c;Subsequent Events&#x201d;) is collateralized by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div>-priority liens on substantially all of the Company's assets, including Company intellectual property. Certain of the Company&#x2019;s subsidiaries have guaranteed the Company&#x2019;s obligations under the GACP Term Loan Facility.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Nikko Note is collateralized by a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div>-priority lien on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10%</div> of the Aprinnova JV interests owned by the Company, as discussed in Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> "Debt".</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Other Matters</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Certain conditions <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>exist as of the date the financial statements are issued, which <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>result in a loss to the Company but will only be recorded when <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> or more future events occur or fail to occur. The Company's management assesses such contingent liabilities, and such assessment inherently involves an exercise of judgement. In assessing loss contingencies related to legal proceedings that are pending against and by the Company or unasserted claims that <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>result in such proceedings, the Company's management evaluates the perceived merits of any legal proceedings or unasserted claims as well as the perceived merits of the amount of relief sought or expected to be sought.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">If the assessment of a contingency indicates that it is probable that a material loss has been incurred and the amount of the liability can be estimated, then the estimated liability would be accrued in the Company's financial statements. If the assessment indicates that a potential material loss contingency is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> probable but is reasonably possible, or is probable but cannot be reasonably estimated, then the nature of the contingent liability, together with an estimate of the range of possible loss if determinable and material would be disclosed. Loss contingencies considered to be remote by management are generally <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> disclosed unless they involve guarantees, in which case the guarantee would be disclosed.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 3, 2019, </div>a securities class action complaint was filed against Amyris and our CEO, John G. Melo, and former CFO (and current Chief Business Officer), Kathleen Valiasek, in the U.S. District Court for the Northern District of California. The complaint seeks unspecified damages on behalf of a purported class that would comprise all persons and entities that purchased or otherwise acquired our securities between <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 15, 2018 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 19, 2019. </div>The complaint alleges securities law violations based on statements and omissions made by the Company during such period. Subsequent to the filing of the securities class action complaint described above, on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 21, 2019, </div>a purported shareholder derivative complaint was filed in the U.S. District Court for the Northern District of California (Bonner v. Doerr, et al., Case <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">No.</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4:19</div>-cv-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">03621</div>) based on similar allegations to those made in the securities class action complaint described above. The derivative complaint names Amyris, Inc. as a nominal defendant and names a number of the Company&#x2019;s current and former officers and directors as additional defendants. The lawsuit seeks to recover, on the Company's behalf, unspecified damages purportedly sustained by the Company in connection with allegedly misleading statements and/or omissions made in connection with the Company&#x2019;s securities filings. The derivative complaint also seeks a series of changes to the Company&#x2019;s corporate governance policies, restitution to the Company from the individual defendants, and an award of attorneys&#x2019; fees. These cases are in the initial pleadings stage. We believe the complaints lack merit, and intend to defend ourselves vigorously. Given the early stage of these proceedings, it is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> yet possible to reliably determine any potential liability that could result from these matters.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company is subject to disputes and claims that arise or have arisen in the ordinary course of business and that have <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> resulted in legal proceedings or have <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> been fully adjudicated. Such matters that <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>arise in the ordinary course of business are subject to many uncertainties and outcomes are <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> predictable with reasonable assurance and therefore an estimate of all the reasonably possible losses cannot be determined at this time. Therefore, if <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> or more of these legal disputes or claims resulted in settlements or legal proceedings that were resolved against the Company for amounts in excess of management&#x2019;s expectations, the Company&#x2019;s consolidated financial statements for the relevant reporting period could be materially adversely affected.</div> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"><div style="display: inline; font-weight: bold;"></div></div></div> 937000 937000 937000 107957000 77864000 78348000 -484000 -12472000 51708000 51992000 -284000 -109366000 -101179000 -100617000 -562000 -230235000 -155982000 -155982000 -230235000 -72329000 -83653000 -83653000 -223096000 -201857000 -93369000 -108488000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><div style="display: inline; font-weight: bold;">New Accounting Standards or Updates Recently Adopted</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;">&nbsp;</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">During the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> the Company adopted the following Accounting Standards Updates (ASUs):</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Revenue Recognition</div></div> The Company adopted ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606,</div> <div style="display: inline; font-style: italic;">Revenue from Contracts with Customers</div>, with a date of initial application of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018. </div>As a result, the Company has changed its accounting policy for revenue recognition as detailed above in &#x201c;Significant Accounting Policies&#x201d;. The Company applied ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606</div> using the modified retrospective approach by recognizing the cumulative effect of initially applying ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606</div> to all contracts <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> completed as of the date of adoption as an adjustment to the opening balance of accumulated deficit at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018. </div>Therefore, the comparative information has <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> been adjusted and continues to be reported under the legacy revenue recognition guidance of ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">605,</div> "Revenue Recognition".</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The Company applied ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606</div> using a practical expedient for contracts that were modified before the application date, which allowed the Company to determine an aggregate effect of all modifications that occurred before <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018, </div>when determining the satisfied and unsatisfied performance obligations, the transaction price, and allocating that transaction price to the performance obligations instead of retrospectively restating the contracts for such contract modifications.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The cumulative effect of initially applying ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606</div> resulted in an increase to accumulated deficit at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018 </div>of approximately <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.8</div> million. The most significant change in accounting policy is the Company is now required to estimate royalty revenues from licenses of the Company&#x2019;s intellectual property and recognize estimated royalty revenues at a point in time when the Company sells its renewable products to its customers (if the sales-based royalty exception does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> apply) or when the licensee sells its products to its customer (if the sales-based royalty exception does apply).</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> </div> <!-- Field: Page; Sequence: 23 --> <!-- Field: /Page --> <div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The following table presents the amounts by which revenue is affected in the current reporting period by the application of ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606</div> as compared with the legacy guidance that was in effect before the accounting change.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div> <table style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;" cellspacing="0" cellpadding="0" align="center"> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="11" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Year Ended December 31, 2018</td> </tr> <tr style="vertical-align: bottom"> <td style="font-weight: bold; border-bottom: Black 1pt solid">(In thousands)</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">As Reported</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Adjustments</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Amounts Without the Adoption of ASC 606</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 52%; text-align: left">Renewable products</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">33,598</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">33,598</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Licenses and royalties</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,658</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,094</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,752</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt">Grants and collaborations</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">22,348</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(5,786</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,562</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt">Total revenue from all customers</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">63,604</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(692</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">)</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">62,912</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Financial Instruments</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 2016, </div>the Financial Accounting Standards Board (FASB) issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">01,</div>&nbsp;<div style="display: inline; font-style: italic;">Financial Instruments-Overall (Subtopic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">825</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div>): Recognition and Measurement of Financial Assets and Financial Liabilities</div>, which changes the accounting for equity investments, financial liabilities under the fair value option, and the presentation and disclosure requirements for financial instruments. The Company adopted ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">01</div> on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018. </div>Adoption&nbsp;of this&nbsp;ASU did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div>&nbsp;impact the Company's consolidated financial position, results of operations or cash flows.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Classification of Cash Flow Elements</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2016, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15,</div>&nbsp;<div style="display: inline; font-style: italic;">Statement of Cash Flows (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">230</div>):&nbsp;Classification of Certain Cash Receipts and Cash Payments,</div>&nbsp;which affects the classification of certain cash receipts and cash payments on the statement of cash flows. ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15</div> results in a change in cash flow classification of debt prepayment or extinguishment costs. ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15</div> became effective <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018 </div>on a retrospective basis. Adoption&nbsp;of this&nbsp;ASU did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div>&nbsp;impact the Company's consolidated financial position, results of operations or cash flows.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Income Taxes Related to Intra-entity Asset Transfers</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 2016, </div>FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> <div style="display: inline; font-style: italic;">Intra-Entity Transfers of Assets Other Than Inventory</div> on simplifying the accounting for income taxes related to intra-entity asset transfers. The new guidance allows an entity to recognize the tax expense from the sale of an asset in the seller&#x2019;s tax jurisdiction when the transfers occurs, even though the pre-tax effects of that transaction are eliminated in consolidation. ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16</div> became effective <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018, </div>which the Company adopted on a modified retrospective basis.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Restricted Cash in Statement of Cash Flows</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2016, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,</div>&nbsp;<div style="display: inline; font-style: italic;">Statement of Cash Flows (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">230</div>): Restricted Cash,</div>&nbsp;which requires that a statement of cash flows explain the change during the period in the total of cash, cash equivalents, and amounts generally described as restricted cash or restricted cash equivalents. Therefore, amounts generally described as restricted cash and restricted cash equivalents should be included with cash and cash equivalents when reconciling the beginning-of-period and end-of-period total amounts shown on the statement of cash flows. The accounting standard update became effective <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018 </div>using a retrospective transition method for each period presented. Upon adoption, ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18</div> resulted in a change in the presentation of restricted cash in the statement of cash flows for current and prior periods presented.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;">&nbsp;</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Derecognition of Nonfinancial Assets</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 2017, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">05,</div>&nbsp;<div style="display: inline; font-style: italic;">Other Income&#x2014;Gains and Losses from the Derecognition of Nonfinancial Assets (Subtopic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">610</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">20</div>): Clarifying the Scope of Asset Derecognition Guidance and Accounting for Partial Sales of Nonfinancial Assets</div>, which requires entities to apply certain recognition and measurement principles in ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606</div> when they derecognize nonfinancial assets, and in substance, nonfinancial assets, and the counterparty is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> a customer. The guidance applies to: (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div>) contracts to transfer to a noncustomer a nonfinancial asset or group of nonfinancial assets, or an ownership interest in a consolidated subsidiary that does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> meet the definition of a business and is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div>-for-profit activity; and (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div>) contributions of nonfinancial assets that are <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> a business to a joint venture or other noncontrolled investee. The accounting standard update became effective <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018 </div>on a modified retrospective basis. Adoption&nbsp;of this&nbsp;ASU did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div>&nbsp;impact the Company's consolidated financial position, results of operations or cash flows.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> </div> <!-- Field: Page; Sequence: 24 --> <!-- Field: /Page --> <div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Income Taxes </div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 2018, </div>FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">05,</div> <div style="display: inline; font-style: italic;">Amendments to SEC Paragraphs Pursuant to SEC Staff Accounting Bulletin <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">No.</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">118</div></div> to address the application of GAAP in situations when a registrant does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> have the necessary information available, prepared or analyzed (including computations) in reasonable detail to complete the accounting for certain income tax effects of the Tax Act. As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018, </div>the Company's analysis for the Transition Tax has been filed with its <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017 </div>tax return and the Company considered its accounting for this area of the Tax Act to be complete as of such date and did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> make any measurement-period adjustments related to it. In addition, the Company considered its accounting for changes in the U.S. federal rate and deferred tax impact for the rate change to be complete. The Company also accounted for the tax impact related to other areas of the Tax Act and believe its analysis to be completed consistent with the guidance in ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">05.</div> The Company recognizes that the IRS is continuing to publish and finalize ongoing guidance with respect to the Act which <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>modify accounting interpretation for the Tax Act, the Company would look to account for these impacts in the period of such change is enacted.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Non-employee Stock-based Compensation</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 2018, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">07,</div> <div style="display: inline; font-style: italic;">Improvements to Nonemployee Share-Based Payment Accounting,</div> which more closely aligns the accounting for employee and nonemployee stock-based compensation. Under the new standard, companies are <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> longer required to value non-employee awards differently from employee awards. The Company adopted this accounting standard update on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018 </div>using a modified retrospective approach. Adoption&nbsp;of this&nbsp;ASU did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div>&nbsp;impact the Company's consolidated financial position, results of operations or cash flows.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><div style="display: inline; font-weight: bold;">Recent Accounting Standards or Updates <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">Not</div> Yet Effective</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Leases</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 2016, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">02,</div>&nbsp;<div style="display: inline; font-style: italic;">Leases (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">842</div>),</div>&nbsp;as subsequently updated, with fundamental changes as to how entities account for leases. Lessees will need to recognize a right-of-use asset and a lease liability for virtually all of their leases (other than leases that meet the definition of a short-term lease). The liability will be equal to the present value of lease payments. The asset will be based on the liability, subject to adjustment, such as for initial direct costs. Additional disclosures for leases will also be required.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The Company is adopting the new standard effective <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2019 </div>using a modified retrospective method, and will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> restate comparative periods. The modified retrospective transition approach requires lessees and lessors to recognize and measure existing leases at the date of initial application. The new standard provides a number of optional practical expedients in transition. The Company expects to elect the &#x201c;package of practical expedients&#x201d;, which permits it <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> to reassess under the new standard prior conclusions about lease identification, lease classification and initial direct costs.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> </div> <!-- Field: Page; Sequence: 25 --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The adoption of this standard on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2019 </div>is expected to have the effect of increasing assets and liabilities on the consolidated balance sheet by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$25.7</div> million, but is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> expected to have a material impact on the consolidated statements of operations or cash flows.&nbsp;The most significant impact relates to (i) the recognition of new Right of Use (ROU) assets and lease liabilities on the balance sheet for operating leases; and (ii) providing significant new disclosures about leasing activities. Upon adoption, the Company will recognize operating lease liabilities of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$33.6</div> million, based on the present value of the remaining minimum rental payments under current leasing standards for existing operating leases.&nbsp;The Company will also recognize ROU assets of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$29.7</div> million, which represents the operating lease liability adjusted for accrued rent.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Financial Instruments with "Down Round" Features</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2017, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,</div>&nbsp;<div style="display: inline; font-style: italic;">Earnings Per Share (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">260</div>); Distinguishing Liabilities from Equity (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">480</div>); Derivatives and Hedging (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">815</div>): Accounting for Certain Financial Instruments with Down Round Features</div>. The amendments of this ASU update the classification analysis of certain equity-linked financial instruments, or embedded features, with down round features, as well as clarify existing disclosure requirements for equity-classified instruments. When determining whether certain financial instruments should be classified as liabilities or equity instruments, a down round feature <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> longer precludes equity classification when assessing whether the instrument is indexed to an entity&#x2019;s own stock. The accounting standard update will be effective beginning in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> quarter of fiscal year <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> using a modified retrospective approach. The Company completed its assessment of the new standard and determined the impact to the consolidated balance sheet would be material. The Company anticipates recording a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$41.0</div> million reduction to derivative liabilities and a corresponding <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$41.0</div> million increase to equity on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2019.</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Fair Value Measurement</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2018, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,</div> <div style="display: inline; font-style: italic;">Fair Value Measurement (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">820</div>): Disclosure Framework&#x2014;Changes to the Disclosure Requirements for Fair Value Measurement</div>, which amends ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">820,</div> <div style="display: inline; font-style: italic;">Fair Value Measurement</div>. ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div> modifies the disclosure requirements for fair value measurements by removing, modifying or adding certain disclosures. The accounting standard update will be effective beginning in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> quarter of fiscal year <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2020,</div> with removed and modified disclosures to be adopted on a retrospective basis, and new disclosures to be adopted on a prospective basis. The Company is in the initial stages of evaluating the impact of the new standard on its consolidated financial statements.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Collaborative Revenue Arrangements</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,</div> <div style="display: inline; font-style: italic;">Clarifying the Interaction between Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">808</div> and Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606</div></div>, that clarifies the interaction between the guidance for certain collaborative arrangements and Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606,</div> the new revenue recognition standard. A collaborative arrangement is a contractual arrangement under which <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> or more parties actively participate in a joint operating activity and are exposed to significant risks and rewards that depend on the activity&#x2019;s commercial success. The ASU provides guidance on how to assess whether certain transactions between collaborative arrangement participants should be accounted for within the revenue recognition standard. The accounting standard update will be effective beginning in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> quarter of fiscal year <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2020</div> retroactively. The Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> believe that the impact of the new standard on its consolidated financial statements will be material.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Credit Losses</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 2016, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,</div> <div style="display: inline; font-style: italic;">Financial Instruments&#x2014;Credit Losses (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">326</div>), Measurement of Credit Losses on Financial Instruments</div>. ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div> requires entities to measure all expected credit losses for most financial assets held at the reporting date based on an expected loss model which includes historical experience, current conditions, and reasonable and supportable forecasts. Entities will now use forward-looking information to better form their credit loss estimates. ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div> also requires enhanced disclosures to help financial statement users better understand significant estimates and judgments used in estimating credit losses, as well as the credit quality and underwriting standards of an entity's portfolio. ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div> will become effective for the Company beginning in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> quarter of fiscal year <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2020.</div> The Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> believe that the impact of the new standard on its consolidated financial statements will be material.</div></div></div></div></div></div></div></div></div></div></div></div> 13111000 10357000 6447000 3357000 198000 178000 19756000 13892000 -93652000 -93054000 -32519000 -60535000 3900000 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2010 2011 2012 2013 2014 2015 2016 2017 2018 -136583000 -56051000 -39515000 -16536000 33600000 29700000 36007000 10416000 3034000 7399000 7226000 7932000 600000 500000 290700000 154300000 7300000 4291000 1233000 1207000 1947000 7958000 12559000 22640000 -10081000 -1187000 -1252000 -1252000 -1252000 -1187000 -1187000 3284000 2633000 23192000 23658000 10632000 13026000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold">December 31,<br /> (In thousands)</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center">(As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 66%; text-align: left">Liability for unrecognized tax benefit</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,582</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,582</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Deferred rent, net of current portion</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,440</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,818</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Ginkgo partnership payments obligation, net of current portion</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,185</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,444</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Contract liabilities, net of current portion</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,587</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">383</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Contract termination fees, net of current portion<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(1)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,530</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Capital leases, net of current portion</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">195</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">217</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Other</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">673</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,214</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Total other noncurrent liabilities</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,192</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,658</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> -2949000 -956000 -955000 -1000 673000 2214000 500000 6800000 1909000 1909000 200000 200000 200000 2159000 2159000 260000 385000 385000 10000000 9000000 3000000 11786000 22140 70904 0.1738 0.1738 5439000 -5439000 0.0001 0.0001 0.0001 5000000 5000000 14656 22171 14656 22171 0 6376 9213 8280 12958 15600000 10566000 4919000 5525000 -606000 5644000 3599000 15000000 5000000 56200000 54400000 72000000 5000000 54800000 54827000 54827000 10000000 1400000 24800000 20000000 23200000 5800000 5000000 5759000 5759000 25900000 94371000 18925000 18925000 2800000 1900000 20000000 16000000 2000000 2000000 5000000 25900000 1415000 14500000 50700000 22100000 30700000 16000000 25000000 12403000 5500000 712000 581000 1293000 676000 288000 160000 -160000 43000000 57767000 43713000 46317000 39922000 40036000 9987000 9555000 3016000 3415000 1749000 2838000 98387000 102161000 5000000 4200000 19756000 13892000 13892000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Property, Plant and Equipment, Net</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Property, plant and equipment are recorded at cost. Depreciation and amortization are computed straight-line based on the estimated useful lives of the related assets, ranging from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div> to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15</div> years for machinery, equipment and fixtures, and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15</div> years for buildings. Leasehold improvements are amortized over their estimated useful lives or the period of the related lease, whichever is shorter.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The Company expenses costs for maintenance and repairs and capitalizes major replacements, renewals and betterments. For assets retired or otherwise disposed, both cost and accumulated depreciation are eliminated from the asset and accumulated depreciation accounts, and gains or losses related to the disposal are recorded in the statement of operations for the period.</div></div></div></div></div></div></div></div></div></div></div></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-size: 10pt; font-weight: bold">December 31,<br /> (In thousands)</td> <td style="font-size: 10pt; font-weight: bold">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; font-weight: bold">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center">(As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 66%; font-size: 10pt; text-align: left">Machinery and equipment</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 14%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">43,713</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 14%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">46,317</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Leasehold improvements</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">39,922</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">40,036</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Computers and software</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,987</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,555</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Furniture and office equipment, vehicles and land</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,016</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,415</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Construction in progress</td> <td style="font-size: 10pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,749</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,838</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; text-indent: 10pt">Total property, plant and equipment, gross</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">98,387</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">102,161</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Less: accumulated depreciation and amortization</td> <td style="font-size: 10pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(78,631</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(88,269</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; text-indent: 10pt">Total property, plant and equipment, net</td> <td style="font-size: 10pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19,756</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,892</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> </tr> </table></div> P3Y P15Y P15Y 141000 6100000 2500000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11.</div> Related Party Transactions</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Related Party Divestiture</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">&nbsp;</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,</div> &#x201c;Divestiture&#x201d; for details regarding the sale of Amyris Brasil to DSM in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2017.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">&nbsp;</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Related Party Equity</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,</div> "Stockholders' Deficit" for details of these related party equity transactions:</div> <div style=" font-size: 10pt; text-indent: 24pt; margin: 0pt 0 0pt 0.5in">&#x2022; <div style="display: inline; font-size: 10pt">&nbsp;&nbsp;&nbsp; </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018 </div>DSM Securities Purchase Agreement</div> <div style=" font-size: 10pt; text-indent: 24pt; margin: 0pt 0 0pt 0.5in">&#x2022; <div style="display: inline; font-size: 10pt">&nbsp;&nbsp;&nbsp; </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2018 </div>Warrant Transactions</div> <div style=" font-size: 10pt; text-indent: 24pt; margin: 0pt 0 0pt 0.5in">&#x2022; <div style="display: inline; font-size: 10pt">&nbsp;&nbsp;&nbsp; </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Offering</div> <div style=" font-size: 10pt; text-indent: 24pt; margin: 0pt 0 0pt 0.5in">&#x2022; <div style="display: inline; font-size: 10pt">&nbsp;&nbsp;&nbsp; </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Offerings</div> <div style=" font-size: 10pt; text-indent: 24pt; margin: 0pt 0 0pt 0.5in">&#x2022; <div style="display: inline; font-size: 10pt">&nbsp;&nbsp;&nbsp; </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Exchange of Common Stock for Series C Convertible Preferred Stock</div> <div style=" font-size: 10pt; text-indent: 24pt; margin: 0pt 0 0pt 0.5in">&#x2022; <div style="display: inline; font-size: 10pt">&nbsp;&nbsp;&nbsp; </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2015 </div>PIPE Warrants</div> <div style=" font-size: 10pt; text-indent: 24pt; margin: 0pt 0 0pt 0.5in">&#x2022; <div style="display: inline; font-size: 10pt">&nbsp;&nbsp;&nbsp; </div>Temasek Funding Warrant</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">&nbsp;</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Related Party Debt</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> "Debt" for details of these related party debt transactions:</div> <div style=" font-size: 10pt; text-indent: 24pt; margin: 0pt 0 0pt 0.5in">&#x2022; <div style="display: inline; font-size: 10pt">&nbsp;&nbsp;&nbsp; </div>DSM Note (also see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,</div> "Divestiture")</div> <div style=" font-size: 10pt; text-indent: 24pt; margin: 0pt 0 0pt 0.5in">&#x2022; <div style="display: inline; font-size: 10pt">&nbsp;&nbsp;&nbsp; </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 2016 </div>Private Placement</div> <div style=" font-size: 10pt; text-indent: 24pt; margin: 0pt 0 0pt 0.5in">&#x2022; <div style="display: inline; font-size: 10pt">&nbsp;&nbsp;&nbsp; </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes</div> <div style=" font-size: 10pt; text-indent: 24pt; margin: 0pt 0 0pt 0.5in">&#x2022; <div style="display: inline; font-size: 10pt">&nbsp;&nbsp;&nbsp; </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2013 </div>Financing Convertible Notes</div> <div style=" font-size: 10pt; text-indent: 24pt; margin: 0pt 0 0pt 0.5in">&#x2022; <div style="display: inline; font-size: 10pt">&nbsp;&nbsp;&nbsp; </div>R&amp;D Note</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Related party debt was as follows:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;" cellspacing="0" cellpadding="0" align="center"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">December 31, </div></div><br /> <div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; text-decoration: underline;">(in thousands)</div></div></div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="11" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="11" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td style="white-space: nowrap">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Principal</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Unamortized <br /> Debt <br /> (Discount) <br /> Premium</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Net</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Principal</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Unamortized <br /> Debt <br /> (Discount) <br /> Premium</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Net</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="white-space: nowrap">Total</td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 40%; text-align: left; text-indent: 10pt">2014 Rule 144A convertible notes</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,705</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(422</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">)</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,283</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,705</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,538</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">)</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 7%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,167</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">August 2013 financing convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">21,711</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">897</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">22,608</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">R&amp;D note</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,700</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(18</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,682</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,705</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(422</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,283</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">35,116</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(659</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">34,457</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>DSM</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">DSM note</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,311</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,689</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(8,039</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,961</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Other DSM loan</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">393</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">393</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,311</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,689</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,393</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(8,039</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">17,354</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Biolding</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">February 2016 private placement</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Foris</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">2014 Rule 144A convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(181</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,819</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(660</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,340</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Temasek</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">2014 Rule 144A convertible notes</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,000</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(435</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,565</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,000</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,591</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,409</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">49,705</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(7,349</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">)</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,356</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">77,509</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(10,949</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">)</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">66,560</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The fair value of the derivative liabilities related to the related party R&amp;D Note, related party <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2013 </div>Financing Convertible Notes (Tranche Notes) and related party <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div> was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.2</div> million, respectively. The Company recognized (losses) gains from change in the fair value of these derivative liabilities of (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.5</div>) million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.6</div> million for the years ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> respectively; see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,</div> "Fair Value Measurement".</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">At <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> Temasek was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> longer a related party. However, the Company and Temasek were related parties when they entered into the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> convertible notes transaction, for which terms have remained unchanged since the borrowing date.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Related Party Revenue</div></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company recognized revenue from related parties and from all other customers as follows:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;" cellspacing="0" cellpadding="0"> <tr style="vertical-align: bottom"> <td style="font-weight: bold">Years Ended December 31,<br /> <div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="15" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017 (As restated, Note 2)</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Renewable Products</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Licenses and Royalties</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Grants and Collaborations</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">TOTAL</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Renewable Products</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Licenses and Royalties</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Grants and Collaborations</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">TOTAL</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Revenue from related parties:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 28%">DSM</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,958</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,735</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,711</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,972</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,679</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">59,651</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Total</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">342</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">342</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(200</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(200</div></td> <td style="text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Novvi</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,491</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,491</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Subtotal revenue from related parties</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">360</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,958</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,735</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,053</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,291</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,972</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,679</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60,942</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left"><div style="display: inline; font-size: 10pt">Revenue from all other customers<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(1)</div></div></td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">33,238</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,700</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">17,613</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">52,551</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">41,079</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(9,269</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">34,919</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">66,729</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Total revenue from all customers</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">33,598</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,658</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">22,348</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">63,604</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,370</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">48,703</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">36,598</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">127,671</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; min-width: 700px;" cellspacing="0" cellpadding="0"> <tr style="vertical-align: top"> <td style="width: 24pt">&nbsp;</td> <td style="width: 18pt"><div style="display: inline; font-size: 10pt">(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div>)</div></td> <td style="text-align: justify"><div style="display: inline; font-size: 10pt">Licenses and royalties revenue is negative for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div> due to the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$13.1</div> million reversal of cumulative to date revenue as a result of entering into the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div> Ginkgo Partnership Agreement. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10.</div> Revenue Recognition.</div></td> </tr> </table> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> "Revenue Recognition" for details of the Company's revenue agreements with DSM.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Related Party Accounts Receivable</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Related party accounts receivable was as follows:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;" cellspacing="0" cellpadding="0" align="center"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">December 31, </div></div><br /> <div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; text-decoration: underline;">(In thousands)</div></div></div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 62%">DSM</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 16%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,071</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 16%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,823</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Novvi</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">188</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,607</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Total</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">90</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">238</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Related party accounts receivable, net</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,349</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">14,668</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In addition to the amounts shown above, there were the following amounts on the consolidated balance sheet at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018:</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0 0pt 0.5in">&#x2022; <div style="display: inline; font-size: 10pt">&nbsp;&nbsp;&nbsp; </div>a total of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.0</div> million of unbilled receivables from DSM, in the lines captioned &#x201c;Accounts receivable, unbilled - related party&#x201d; and &#x201c;Accounts receivable, unbilled, noncurrent - related party&#x201d;; and</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-indent: 24pt; margin: 0pt 0 0pt 0.5in">&#x2022; <div style="display: inline; font-size: 10pt">&nbsp;&nbsp;&nbsp; </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.3</div> million of contingent consideration receivable from DSM in the line captioned "Other assets".</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">&nbsp;</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Related Party Accounts Payable</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">Amounts due to DSM that were included in Accounts payable and Accrued and other current liabilities at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018 </div>were <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.1</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.6</div> million, respectively.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"></div></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Related Party DSM Transactions</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">&nbsp;</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">The Company is party to the following significant agreements (and related amendments) with related party DSM:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <table style="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; min-width: 700px;" cellspacing="0" cellpadding="0" align="center"> <tr style="vertical-align: bottom"> <td style="width: 20%; border-bottom: Black 1pt solid"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">Related to</div></div></td> <td style="width: 45%; border-bottom: Black 1pt solid"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">Agreement</div></div></td> <td style="width: 35%; border-bottom: Black 1pt solid"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">For Additional Information, See the Note Indicated</div></div></td> </tr> <tr style="vertical-align: top; background-color: rgb(204,238,255)"> <td>Debt</td> <td>DSM Credit Agreement</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.</div> Debt<br /> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10.</div> Revenue Recognition</td> </tr> <tr style="vertical-align: top; background-color: White"> <td>Debt</td> <td>DSM Note</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.</div> Debt</td> </tr> <tr style="vertical-align: top; background-color: rgb(204,238,255)"> <td>Debt</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018 </div>DSM Letter Agreement</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.</div> Debt</td> </tr> <tr style="vertical-align: top; background-color: White"> <td>Divestiture</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2017 </div>Quota Purchase Agreement</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13.</div> Divestiture</td> </tr> <tr style="vertical-align: top; background-color: rgb(204,238,255)"> <td>Divestiture</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2017 </div>DSM Transition Services Agreement</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13.</div> Divestiture</td> </tr> <tr style="vertical-align: top; background-color: White"> <td>Equity</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Offerings</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7.</div> Stockholders' Deficit</td> </tr> <tr style="vertical-align: top; background-color: rgb(204,238,255)"> <td>Equity</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Offering</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7.</div> Stockholders' Deficit</td> </tr> <tr style="vertical-align: top; background-color: White"> <td>Equity</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018 </div>DSM Securities Purchase Agreement</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7.</div> Stockholders' Deficit</td> </tr> <tr style="vertical-align: top; background-color: rgb(204,238,255)"> <td>Revenue</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 2017 </div>Collaboration and Licensing Agreements</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10.</div> Revenue Recognition</td> </tr> <tr style="vertical-align: top; background-color: White"> <td>Revenue</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2017 </div>DSM Supply Agreement</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10.</div> Revenue Recognition</td> </tr> <tr style="vertical-align: top; background-color: rgb(204,238,255)"> <td>Revenue</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2017 </div>DSM Value Sharing Agreement, as amended</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10.</div> Revenue Recognition</td> </tr> <tr style="vertical-align: top; background-color: White"> <td>Revenue</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2017 </div>DSM Performance Agreement</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10.</div> Revenue Recognition</td> </tr> <tr style="vertical-align: top; background-color: rgb(204,238,255)"> <td>Revenue</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2017 </div>Intellectual Property License Agreement</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10.</div> Revenue Recognition</td> </tr> <tr style="vertical-align: top; background-color: White"> <td>Revenue</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018 </div>Supply Agreement Amendment</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10.</div> Revenue Recognition</td> </tr> </table> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">&nbsp;</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">Concurrent with the sale of Amyris Brasil in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2017, </div>the Company and DSM entered into a series of commercial agreements including (i) a license agreement to DSM of its farnesene product for DSM to use in the Vitamin E and lubricant markets; (ii) a royalty agreement that DSM will pay the Company specified royalties representing a portion of the profit on the sale of Vitamin E produced from farnesene under the Nenter Supply Agreement assigned to DSM; (iii) a performance agreement, which provides an option for DSM to elect a technology transfer upon the achievement of certain development milestones associated with the optimization of farnesene strains; and (iv) a transition services agreement for the Company to provide finance, legal, logistics, and human resource services to support the Brotas facility under DSM ownership for a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">six</div>-month period with a DSM option to extend for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">six</div> additional months. At closing, DSM paid the Company a nonrefundable license fee of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$27.5</div> million and a nonrefundable royalty payment of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$15.0</div> million. In addition, in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2017 </div>the Company entered into a credit agreement with DSM under which the Company borrowed <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$25</div> million; see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> "Debt" for additional information.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 2018, </div>DSM paid the Company a non-refundable minimum royalty payment of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$9.3</div> million (net of a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.7</div> million early payment discount) and will also owe the Company a final payment of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.1</div> million in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019.</div> The future nonrefundable minimum annual royalty payments were determined to be fixed and determinable with a fair value of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$17.8</div> million and were included as part of the total arrangement consideration subject to allocation of this overall multiple-element divestiture transaction.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018, </div>the Company amended the supply agreement with DSM to secure capacity at the Brotas <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div> facility for Reb M production thru <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2022.</div> See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> &#x201c;Revenue Recognition&#x201d; for information regarding the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018 </div>Supply Agreement Amendment and the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018 </div>DSM Securities Purchase Agreement. The Company also entered into other transactions with DSM in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018 </div>which resulted in the Company (i) evaluating this series of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018 </div>transactions and considering other certain transactions with DSM in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> as a combined arrangement, and (ii) determining and allocating the fair value to each element. The other transactions entered into concurrently with the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018 </div>Supply Agreement Amendment and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018 </div>DSM Securities Purchase Agreement included an agreement to finalize the working capital adjustments related to the Brotas <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div> facility sale in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2017 </div>and an amendment to reduce the exercise price of the Cash Warrant issued to DSM in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Offering and to provide a waiver for any potential claims arising from failure to obtain consent prior to amending the exercise price of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Cash Warrant in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Warrant transaction.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The contractual consideration transferred to DSM under the combined arrangement was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$34.7</div> million. The Company performed an analysis to determine the fair value of the elements and allocated (i) <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$24.4</div> million to the manufacturing capacity, (ii) <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.8</div> million to the legal settlement and related consent waiver and (iii) <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.1</div> million to the working capital adjustment. Of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$24.4</div> million fair value allocated to the manufacturing capacity, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.3</div> million was recorded as deferred cost of revenue during the period ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018 </div>and the remaining <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$21.0</div> million will be recorded as deferred cost of revenue in the period the additional payments are due and payable to DSM. The deferred cost of revenue asset will be expensed on a units of production basis as products are sold over the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">five</div>-year term of the supply agreement and evaluated for recoverability at each period end. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.8</div> million of fair value allocated to the legal settlement and related consent waiver was recorded as legal settlement expense for the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018. </div>The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.1</div> million of fair value allocated to the working capital adjustment was recorded as a loss on divestiture for the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018. </div>The contractual consideration transferred to DSM exceeded the fair value of the elements received by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.4</div> million and this excess was recorded as a reduction of licenses and royalties revenues in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> months ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Related Party Joint Venture</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2016, </div>the Company, Nikko Chemicals Co., Ltd. an existing commercial partner of the Company, and Nippon Surfactant Industries Co., Ltd., an affiliate of Nikko (collectively, Nikko) entered into a joint venture (the Aprinnova JV Agreement) pursuant to which the Company contributed certain assets, including certain intellectual property and other commercial assets relating to its business-to-business cosmetic ingredients business (the Aprinnova JV Business), as well as its Leland production facility. The Company also agreed to provide the Aprinnova JV with exclusive (to the extent <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> already granted to a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">third</div> party), royalty-free licenses to certain of the Company's intellectual property necessary to make and sell products associated with the Aprinnova JV Business (the Aprinnova JV Products). Nikko purchased their <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50%</div> interest in the Aprinnova JV in exchange for the following payments to the Company: (i) an initial payment of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$10.0</div> million and (ii) the profits, if any, distributed to Nikko in cash as members of the Aprinnova JV during the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div>-year period from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div> to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> up to a maximum of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$10.0</div> million.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Aprinnova JV operates in accordance with the Aprinnova Operating Agreement under which the Aprinnova JV is managed by a Board of Directors consisting of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">four</div> directors: <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> appointed by the Company and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> appointed by Nikko. In addition, Nikko has the right to designate the Chief Executive Officer of the Aprinnova JV from among the directors and the Company has the right to designate the Chief Financial Officer. The Company determined that it has the power to direct the activities of the Aprinnova JV that most significantly impact its economic performance because of its (i) significant control and ongoing involvement in operational decision making, (ii) guarantee of production costs for certain Aprinnova JV products, as discussed below, and (iii) control over key supply agreements, operational and administrative personnel and other production inputs. The Company has concluded that the Aprinnova JV is a variable-interest entity (VIE) under the provisions of ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">810,</div> Consolidation, and that the Company has a controlling financial interest and is the VIE's primary beneficiary. As a result, the Company accounts for its investment in the Aprinnova JV on a consolidation basis in accordance with ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">810.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Under the Aprinnova Operating Agreement, profits from the operations of the Aprinnova JV, if any, are distributed as follows: (i) first, to the Company and Nikko (the Members) in proportion to their respective unreturned capital contribution balances, until each Member&#x2019;s unreturned capital contribution balance equals <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">zero</div> and (ii) second, to the Members in proportion to their respective interests. In addition, any future capital contributions will be made by the Company and Nikko on an equal (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50%/50%</div>) basis each time, unless otherwise mutually agreed.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Pursuant to the Aprinnova JV Agreement, the Company and Nikko agreed to make working capital loans to the Aprinnova JV in the amounts of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.5</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.5</div> million, respectively, as described in more detail in Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> &#x201c;Debt&#x201d; under &#x201c;Aprinnova Working Capital Loans&#x201d;. In addition, the Company agreed to guarantee a maximum production cost for squalane and hemisqualane to be produced by the Aprinnova JV and to bear any cost of production above such guaranteed costs.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In connection with the contribution of the Leland Facility by the Company to the Aprinnova JV, at the closing of the formation of the Aprinnova JV, Nikko made a loan to the Company in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.9</div> million, and the Company in consideration therefore issued a promissory note to Nikko in an equal principal amount, as described in more detail in Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> &#x201c;Debt&#x201d; under &#x201c;Nikko Note.&#x201d;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The following presents the carrying amounts of the Aprinnova JV&#x2019;s assets and liabilities included in the accompanying consolidated balance sheets. Assets presented below are restricted for settlement of the Aprinnova JV's obligations and all liabilities presented below can only be settled using the Aprinnova JV resources.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div> <table style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;" cellspacing="0" cellpadding="0" align="center"> <tr style="vertical-align: bottom"> <td style="font-weight: bold"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">December 31, <br /> <div style="display: inline; text-decoration: underline;">(In thousands)</div></div></div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 68%">Assets</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,904</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,635</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Liabilities</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,364</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,187</div></td> <td style="text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Aprinnova JV's assets and liabilities are primarily comprised of inventory, property, plant and equipment, accounts payable and debt, which are classified in the same categories in the Company's consolidated balance sheets.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">There was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> change in noncontrolling interest for the Aprinnova JV for the years ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> due to profit sharing provisions whereby the Company retains <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100%</div> of the profits from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div> to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2020.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Office Sublease</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The Company subleases certain office space to Novvi, for which the Company charged Novvi <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.6</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.5</div> million for the years ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> respectively.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> &#x201c;Subsequent Events&#x201d; for information regarding related party transactions subsequent to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018.</div></div></div> 12600000 5500000 981000 15200000 9800000 41668000 37500000 37500000 68722000 57562000 57027000 -72000 607000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Research and Development</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Research and development costs are expensed as incurred and include costs associated with research performed pursuant to collaborative agreements and government grants, including internal research. Research and development costs consist of direct and indirect internal costs related to specific projects, as well as fees paid to others that conduct certain research activities on the Company&#x2019;s behalf.</div></div></div></div></div></div></div></div></div></div></div></div> 741000 2994000 2994000 1000000 1000000 960000 959000 959000 3063000 3587000 -1521417000 -800000 -1290420000 -1206767000 -83653000 9000000 7900000 27500000 54600000 27500000 15000000 9300000 8100000 27500000 15000000 54700000 33598000 42370000 7658000 48703000 22348000 36598000 63604000 127671000 33598000 5094000 12752000 -5786000 16562000 -692000 62912000 29405000 23823000 26241000 78286000 6331000 23290000 942000 2159000 685000 113000 18000 5958000 4735000 10711000 57972000 1679000 59651000 3727000 1700000 5717000 11144000 9621000 1199000 5803000 16623000 8436000 8436000 12333000 12333000 4078000 4358000 8436000 1950000 6000000 7950000 12057000 2633000 14690000 -13113000 -13113000 7823000 7658000 23246000 38727000 23628000 48691000 25815000 98134000 25775000 -898000 24877000 18742000 12000 10783000 29537000 33598000 42370000 45781000 -3411000 57703000 6774000 -15774000 39960000 -3363000 1000 143444000 -15773000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Revenue Recognition</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 7pt 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; text-decoration: underline;">Year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">For the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017, </div>the Company recognized revenue from the sale of renewable products, licenses of and royalties from intellectual property, and grants and collaborative research and development services. Revenue was recognized when all of the following criteria were met: persuasive evidence of an arrangement existed, delivery has occurred or services have been rendered, the fee was fixed or determinable, and collectability was reasonably assured. If sales arrangements contained multiple elements, the Company evaluated whether the components of each arrangement represent separate units of accounting.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">&nbsp;</div></div> </div> <!-- Field: Page; Sequence: 17 --> <div><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;"></div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Renewable Product Sales</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The Company&#x2019;s renewable product sales do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> include rights of return, except for sales of Biossance products. Returns are only accepted if the product does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> meet product specifications and such nonconformity is communicated to the Company within a set number of days of delivery. The Company offers a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div>-year standard warranty provision for squalane products, if the products do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> meet Company-established criteria as set forth in the Company&#x2019;s trade terms. The Company bases its return reserve on a historical rate of return for the Company&#x2019;s squalane products. Revenues are recognized, net of discounts and allowances, once passage of title and risk of loss has occurred and contractually specified acceptance criteria have been met, provided all other revenue recognition criteria have also been met.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Licenses and Royalties</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">License fees for intellectual property transferred to other parties, representing non-refundable payments received at the time of signature of license agreements, are recognized as revenue upon signature of the license agreements when the Company has <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> significant future performance obligations and collectability of the fees is assured. Upfront payments received at the beginning of licensing agreements with future service obligations are deferred and recognized as revenue on a systematic basis over the period during which the related services are rendered and all obligations are performed.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Royalties from intellectual property licenses that allow Amyris's customers to use the Company&#x2019;s intellectual property to produce and sell their products in which the Company shares in the profits are recognized in the period the royalty report is received.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Grants and Collaborative Research and Development Services</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Revenues from collaborative research and development services are recognized as the services are performed consistent with the performance requirements of the contract. In cases where the planned levels of research and development services fluctuate over the research term, the Company recognizes revenues using the proportional performance method based upon actual efforts to date relative to the amount of expected effort to be incurred by us. When up-front payments are received and the planned levels of research and development services do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> fluctuate over the research term, revenues are recorded on a ratable basis over the arrangement term, up to the amount of cash received. When up-front payments are received and the planned levels of research and development services fluctuate over the research term, revenues are recorded using the proportional performance method, up to the amount of cash received. Where arrangements include milestones that are determined to be substantive and at risk at the inception of the arrangement, revenues are recognized upon achievement of the milestone and is limited to those amounts whereby collectability is reasonably assured.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Grants are agreements that generally provide cost reimbursement for certain types of expenditures in return for research and development activities over a contractually defined period. Revenues from grants are recognized in the period during which the related costs are incurred, provided that the conditions under which the grants were provided have been met and only perfunctory obligations are outstanding.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;"></div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;"></div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018</div></div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">In accordance with a new revenue recognition standard that the Company adopted <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018, </div>the Company recognizes revenue from the sale of renewable products, licenses of and royalties from intellectual property, and grants and collaborative research and development services. Revenue is measured based on the consideration specified in a contract with a customer, and transaction price is allocated utilizing stand-alone selling price. Revenue is recognized when, or as, the Company satisfies a performance obligation by transferring control over a product or service to a customer. The Company generally does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> incur costs to obtain new contracts. The costs to fulfill a contract are expensed as incurred.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The Company accounts for a contract when it has approval and commitment to perform from both parties, the rights of the parties are identified, payment terms are established, the contract has commercial substance and collectability of the consideration is probable. Changes to contracts are assessed for whether they represent a modification or should be accounted for as a new contract. The Company considers the following indicators, among others, when determining if it is acting as a principal in the transaction and recording revenue on a gross basis: (i) the Company is primarily responsible for fulfilling the promise to provide the specified goods or service, (ii) the Company has inventory risk before the specified good or service has been transferred to a customer or after transfer of control to the customer and (iii) the Company has discretion in establishing the price for the specified good or service. If a transaction does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> meet the Company's indicators of being a principal in the transaction, then the Company is acting as an agent in the transaction and the associated revenues are recognized on a net basis.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> </div> <!-- Field: Page; Sequence: 18 --> <!-- Field: /Page --> <div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The Company&#x2019;s significant contracts and contractual terms with its customers are presented in Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> "Revenue Recognition".</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The Company recognizes revenue when control has passed to the customer. The following indicators are evaluated in determining when control has passed to the customer: (i) the Company has a right to receive payment for the product or service, (ii) the customer has legal title to the product, (iii) the Company has transferred physical possession of the product to the customer, (iv) the customer has the significant risk and rewards of ownership of the product and (v) the customer has accepted the product. For most of the Company's renewable products customers, supply agreements between the Company and each customer indicate when transfer of title occurs.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">In some cases, the Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>make a payment to a customer. When that occurs, the Company evaluates whether the payment is for a distinct good or service receivable from the customer. If the fair value of the goods or services receivable is greater than or equal to the amount paid to the customer, then the entire payment is treated as a purchase. If, on the other hand, the fair value of goods or services is less than the amount paid, then the difference is treated as a reduction in transaction price of the Company's sales to the customer.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Performance Obligations</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">A performance obligation is a promise in a contract to transfer a distinct good or service to the customer. A contract&#x2019;s transaction price is allocated to each distinct performance obligation and recognized as revenue when, or as, the performance obligation is satisfied. The Company's contracts <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>contain multiple performance obligations if a promise to transfer the individual goods or services is separately identifiable from other promises in the contracts and, therefore, is considered distinct. For contracts with multiple performance obligations, the Company determines the standalone selling price of each performance obligation and allocates the total transaction price using the relative selling price basis.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The following is a description of the principal goods and services from which the Company generates revenue.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Renewable Product Sales</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Revenues from renewable product sales are recognized as a distinct performance obligation on a gross basis as the Company is acting as a principal in these transactions, with the selling price to the customer recorded net of discounts and allowances. Revenues are recognized at a point in time when control has passed to the customer, which typically is upon the renewable products leaving the Company&#x2019;s facilities with the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> transportation carrier. The Company, on occasion, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>recognize revenue under a bill and hold arrangement, whereby the customer requests and agrees to purchase product but requests delivery at a later date. Under these arrangements, control transfers to the customer when the product is ready for delivery, which occurs when the product is identified separately as belonging to the customer, the product is ready for shipment to the customer in its current form, and the Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> have the ability to direct the product to a different customer. It is at this point that the Company has the right to receive payment, the customer obtains legal title, and the customer has the significant risks and rewards of ownership. The Company&#x2019;s renewable product sales do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> include rights of return, except for Biossance products, for which the Company estimates sales returns subsequent to sale and reduces revenue accordingly. For renewable products other than Biossance, returns are accepted only if the product does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> meet product specifications and such nonconformity is communicated to the Company within a set number of days of delivery. The Company offers a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div>-year assurance-type warranty to replace squalane products that do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> meet Company-established criteria as set forth in the Company&#x2019;s trade terms. An estimate of the cost to replace the squalane products sold is made based on a historical rate of experience and recognized as a liability and related expense when the renewable product sale is consummated.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> </div> <!-- Field: Page; Sequence: 19 --> <!-- Field: /Page --> <div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Licenses and Royalties</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Licensing of Intellectual Property: </div>When the Company&#x2019;s intellectual property licenses are determined to be distinct from the other performance obligations identified in the arrangement, revenue is recognized from non-refundable, up-front fees allocated to the license at a point in time when the license is transferred to the licensee and the licensee is able to use and benefit from the license. For intellectual property licenses that are combined with other promises, the Company utilizes judgment to assess the nature of the combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purposes of recognizing revenue from non-refundable, up-front-fees. The Company evaluates the measure of progress each reporting period and, if necessary, adjusts the measure of performance and related revenue recognized.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Royalties from Licensing of Intellectual Property:</div> The Company earns royalties from the licensing of its intellectual property whereby the licensee uses the intellectual property to produce and sell its products to its customers and the Company shares in the profits.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">When the Company&#x2019;s intellectual property license is the only performance obligation, or it is the predominant performance obligation in arrangements with multiple performance obligations, the Company applies the sales-based royalty exception which requires the Company to estimate the revenue that is recognized at a point in time when the licensee&#x2019;s product sales occur. Estimates of sales-based royalty revenues are made using the most likely outcome method, which is the single amount in a range of possible amounts, using the best evidence available at the time, derived from the licensee&#x2019;s historical sales volumes and sales prices of its products and recent commodity market pricing data and trends. Estimates are adjusted to actual or as new information becomes available.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">When the Company&#x2019;s intellectual property license is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> the predominant performance obligation in arrangements with multiple performance obligations, the royalty represents variable consideration and is allocated to the transaction price of the predominant performance obligation which generally is the supply of renewable products to the Company's customers. Revenue is estimated and recognized at a point in time when the renewable products are delivered to the customer. Estimates of the amount of variable consideration to include in the transaction price are made using the expected value method, which is the sum of probability-weighted amounts in a range of possible amounts determined based on the cost to produce the renewable product plus a reasonable margin for the profit share. The Company only includes an amount of variable consideration in the transaction price to the extent it is probable that a significant reversal in the cumulative revenue recognized will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> occur when the uncertainty associated with the variable consideration is subsequently resolved. Also, the transaction price is reduced for estimates of customer incentive payments payable by the Company for certain customer contracts.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Grants and Collaborative Research and Development Services</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Collaborative Research and Development Services:</div> The Company earns revenues from collaboration agreements with customers to perform research and development services to develop new molecules using the Company&#x2019;s technology and to scale production of the molecules for commercialization and use in the collaborator&#x2019;s products. The collaboration agreements generally include providing the Company's collaboration partners with research and development services and with licenses to the Company&#x2019;s intellectual property to use the technology underlying the development of the molecules and to sell its products that incorporate the technology. The terms of the Company's collaboration agreements typically include <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> or more of the following: advance payments for the research and development services that will be performed, nonrefundable upfront license payments, milestone payments to be received upon the achievement of the milestone events defined in the agreements, and royalty payments upon the commercialization of the molecules in which the Company shares in the customer&#x2019;s profits.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> </div> <!-- Field: Page; Sequence: 20 --> <div><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Collaboration agreements are evaluated at inception to determine whether the intellectual property licenses represent distinct performance obligations separate from the research and development services. If the licenses are determined to be distinct, the non-refundable upfront license fee is recognized as revenue at a point in time when the license is transferred to the licensee and the licensee is able to use and benefit from the license while the research and development service fees are recognized over time as the performance obligations are satisfied. The research and development service fees represent variable consideration. Estimates of the amount of variable consideration to include in the transaction price are made using the expected value method, which is the sum of probability-weighted amounts in a range of possible amounts. The Company only includes an amount of variable consideration in the transaction price to the extent it is probable that a significant reversal in the cumulative revenue recognized will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> occur when the uncertainty associated with the variable consideration is subsequently resolved. Revenue is recognized over time using either an input-based measure of labor hours expended or a time-based measure of progress towards the satisfaction of the performance obligations. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Collaboration agreements that include milestone payments are evaluated at inception to determine whether the milestone events are considered probable of achievement, and estimates are made of the amount of the milestone payments to include in the transaction price using the most likely amount method which is the single amount in a range of possible amounts. If it is probable that a significant revenue reversal will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> occur, the estimated milestone payment amount is included in the transaction price. Each reporting period, the Company re-evaluates the probability of achievement of the milestone events and any related constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative basis, which would affect collaboration revenues in the period of adjustment. Generally, revenue is recognized using an input-based measure of progress towards the satisfaction of the performance obligations which can be labor hours expended or time-based in proportion to the estimated total project effort or total projected time to complete. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized. Certain performance obligations are associated with milestones agreed between the Company and its customer. Revenue generated from the performance of services in accordance with these milestones is recognized upon confirmation from the customer that the milestone has been achieved. In these cases, amounts recognized are constrained to the amount of consideration received upon achievement of the milestone.&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The Company generally invoices its collaboration partners on a monthly or quarterly basis, or upon the completion of the effort or achievement of a milestone, based on the terms of each agreement. Deferred revenue arises from amounts received in advance of performing the research and development activities and is recognized as revenue in future periods as the performance obligations are satisfied.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Grants:</div> The Company earns revenues from grants with government agencies to, among other things, provide research and development services to develop molecules using the Company&#x2019;s technology, and create research and development tools to improve the timeline and predictability for scaling molecules from proof of concept to market by reducing time and costs. Grants typically consist of research and development milestone payments to be received upon the achievement of the milestone events defined in the agreements.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The milestone payments are evaluated at inception to determine whether the milestone events are considered probable of achievement and estimates are made of the amount of the milestone payments to include in the transaction price using the most likely amount method which is the single amount in a range of possible amounts. If it is probable that a significant revenue reversal will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> occur, the estimated milestone payment amount is included in the transaction price. Each reporting period, the Company re-evaluates the probability of achievement of the milestone events and any related constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative basis, which would affect grant revenues in the period of adjustment. Revenue is recognized over time using a time-based measure of progress towards the satisfaction of the performance obligations. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> </div></div></div></div></div></div></div></div></div></div></div></div> 360000 1291000 5958000 57972000 4735000 1679000 1053000 60942000 14131000 7925000 22056000 P1Y P1Y P1Y P1Y <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; text-align: left; text-decoration: underline"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">As of December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 79%; text-align: left">2019</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 18%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">14,131</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2020</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,925</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">2021</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2022 and thereafter</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Total from all customers</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">22,056</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> 7800000 7800000 18000 5958000 4735000 10711000 57972000 1679000 59651000 342000 342000 -200000 -200000 1491000 1491000 360000 5958000 4735000 11053000 1291000 57972000 1679000 60942000 33238000 1700000 17613000 52551000 41079000 -9269000 34919000 66729000 33598000 7658000 22348000 63604000 42370000 48703000 36598000 127671000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-size: 10pt; font-weight: bold">Years Ended December 31,</td> <td style="font-size: 10pt; font-weight: bold">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; font-weight: bold">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; white-space: nowrap">(As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 72%; font-size: 10pt; text-align: left">Period-end common stock warrants</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 11%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,986,370</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 11%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29,921,844</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Convertible promissory notes (1)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,703,162</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,203,821</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Period-end stock options to purchase common stock</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,392,269</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,338,367</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Period-end restricted stock units</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,294,848</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">685,007</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Period-end preferred shares on an as-converted basis</td> <td style="font-size: 10pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,955,732</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,504,212</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Total potentially dilutive securities excluded from computation of diluted net loss per share</td> <td style="font-size: 10pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">53,332,381</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">44,653,251</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">Years Ended December 31, <br /> <div style="display: inline; text-decoration: underline;">(In thousands)</div></div></div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td style="font-weight: bold; text-align: left">&nbsp;</td> <td style="font-weight: bold; text-align: right; white-space: nowrap"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">(As Restated, Note 2)</div></div></td> <td style="font-weight: bold; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Current:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 68%">Federal</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,564</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>State</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Foreign</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">964</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Total current provision</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,546</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Deferred:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Federal</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(669</div></td> <td style="text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>State</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Foreign</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Total deferred benefit</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(669</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Total provision for income taxes$</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,877</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; border-bottom: Black 1pt solid">Debt Instrument</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Number of Shares into Which <br /> Debt Instrument Is Convertible <br /> as of December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 84%; text-align: left">6% convertible notes due 2021</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,493,672</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2015 Rule 144A convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,338,560</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">August 2013 financing convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,003,554</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2014 Rule 144A convertible notes</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">867,376</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,703,162</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold; text-align: left">Years ending December&nbsp;31<br /> (In thousands)</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Convertible Notes</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Loans<br /> Payable and Credit Facilities</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Related Party Convertible Notes</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Related Party Loans Payable and Credit Facilities</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 45%; text-align: left">2019</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 8%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">134,368</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 8%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,219</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 8%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,508</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 8%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,500</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 8%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">172,595</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2020</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,981</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,500</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,481</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">2021</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">34,740</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">27,521</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">62,261</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2022</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,417</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,417</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">2023</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">367</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">367</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Thereafter</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,200</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,200</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Total future minimum payments</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">134,368</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">70,924</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,508</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">32,521</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">263,321</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left"><div style="display: inline; font-size: 10pt">Less: amount representing interest<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(1)</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(7,368</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(18,014</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(803</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(7,521</div></td> <td style="text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(33,706</div></td> <td style="text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Less: future conversion of accrued interest to principal</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(694</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(694</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Present value of minimum debt payments</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">126,306</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">52,910</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,705</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">228,921</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Less: current portion of debt principal</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(126,306</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,829</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(24,705</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(154,840</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Noncurrent portion of debt principal</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">49,081</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">74,081</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">December 31, </div></div><br /> <div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; text-decoration: underline;">(In thousands)</div></div></div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="15" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="11" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td style="white-space: nowrap">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Principal</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Unamortized <br /> Debt <br /> (Discount) <br /> Premium</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Change in <br /> Fair Value</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Net</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Principal</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Unamortized <br /> Debt <br /> (Discount) <br /> Premium</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Net</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-style: italic; text-align: left">Convertible notes payable</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-weight: bold;">(As Restated, Note 2)</div></div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 37%; text-align: left">6% convertible notes due 2021</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60,000</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,082</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">)</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,918</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; width: 1%; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">2015 Rule 144A convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">37,887</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,413</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">35,474</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">37,887</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(9,458</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28,429</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2014 Rule 144A convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,004</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(867</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,137</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,004</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,170</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">20,834</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">August 2013 financing convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,415</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(70</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,345</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,009</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,126</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,883</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>December 2017 convertible notes</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,000</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(25</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,975</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">126,306</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,350</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,082</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">120,874</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">70,900</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(14,779</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">56,121</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-style: italic; text-align: left">Related party convertible notes payable</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">2014 Rule 144A convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,705</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,038</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,667</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,705</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,784</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">20,921</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">August 2013 financing convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">21,711</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">897</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">22,608</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">R&amp;D note</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,700</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(18</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,682</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,705</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,038</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,667</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50,116</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,905</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">47,211</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-style: italic; text-align: left">Loans payable and credit facilities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">GACP term loan facility</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">36,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,349</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">34,651</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Ginkgo note</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(4,047</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,953</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(4,862</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,138</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Other loans payable</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,910</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,047</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,863</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,463</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,277</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,186</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Senior secured loan facility</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28,566</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(253</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28,313</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Other credit facilities</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">381</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">381</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">52,910</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,443</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">46,467</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">47,410</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,392</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">41,018</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-style: italic; text-align: left">Related party loans payable</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">DSM note</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,311</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,689</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(8,039</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,961</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>February 2016 private placement</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,000</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Other DSM loan</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">393</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">393</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,311</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,689</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">27,393</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(8,039</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19,354</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Total debt</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">228,921</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(17,142</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">)</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,082</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">209,697</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">195,819</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(32,115</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">163,704</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Less: current portion</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(147,677</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(56,943</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Long-term debt, net of current portion</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">62,020</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">106,761</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">December 31, <br /> <div style="display: inline; text-decoration: underline;">(In thousands)</div></div></div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td style="white-space: nowrap">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center">(As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 72%; text-align: left">Net operating loss carryforwards</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,921</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">20,066</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Property, plant and equipment</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,269</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,653</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Research and development credits</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,046</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,480</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Foreign tax credit</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Accruals and reserves</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,526</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,286</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Stock-based compensation</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,496</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,471</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Disallowed interest carryforward</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,359</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Capitalized start-up costs</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Capitalized research and development costs</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">27,888</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">32,085</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Intangible and others</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,114</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,584</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Equity investments</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">156</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Total deferred tax assets</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">127,775</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">87,625</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Debt discount and derivatives</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,750</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,539</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Total deferred tax liabilities</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,750</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,539</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Net deferred tax assets prior to valuation allowance</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">124,025</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">81,086</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Less: valuation allowance</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(124,025</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(81,086</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Net deferred tax assets</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">December 31, </div></div><br /> <div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; text-decoration: underline;">(In thousands)</div></div></div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; text-align: center">&nbsp;</td> <td style="font-weight: bold; text-align: center">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center">&nbsp;</td> <td style="font-weight: bold; text-align: center">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center">(As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 66%; text-align: left">Equity-related derivative liabilities</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">41,272</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">108,887</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Debt-related derivative liabilities</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,524</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,610</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Total derivative liabilities</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,796</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">116,497</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-size: 10pt; font-weight: bold"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">Years Ended December 31, <br /> <div style="display: inline; text-decoration: underline;">(In thousands, except shares and per share amounts)</div></div></div></td> <td style="font-size: 10pt; font-weight: bold">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt; text-align: center"><div style="display: inline; font-weight: bold;">(As Restated, Note 2)</div></td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 72%; font-size: 10pt; text-align: left">Net loss attributable to Amyris, Inc.</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 11%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(230,235</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">)</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 11%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(155,982</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Less deemed dividend related to beneficial conversion feature on Series A preferred stock</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(562</div></td> <td style="font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Less deemed dividend related to beneficial conversion feature on Series B preferred stock</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(634</div></td> <td style="font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Less deemed dividend related to beneficial conversion feature on Series D preferred stock</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(5,757</div></td> <td style="font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Less deemed dividend upon settlement of make-whole provision on Series A preferred stock</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(10,505</div></td> <td style="font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Less deemed dividend upon settlement of make-whole provision on Series B preferred stock</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(22,632</div></td> <td style="font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Less deemed dividend related to the recognition of discounts on Series A preferred stock upon conversion</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(21,578</div></td> <td style="font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Less deemed dividend related to the recognition of discounts on Series B preferred stock upon conversion</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(24,366</div></td> <td style="font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Less deemed dividend related to proceeds discount upon conversion of Series D preferred stock</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,852</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Add: losses allocated to participating securities</td> <td style="font-size: 10pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,991</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">40,159</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Net loss attributable to Amyris, Inc. common stockholders</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(223,096</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(201,857</div></td> <td style="font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; font-style: italic">Denominator:</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Weighted-average shares of common stock outstanding used in computing net loss per share of common stock, basic and diluted</td> <td style="font-size: 10pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60,405,910</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">32,253,570</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Basic and diluted loss per share</td> <td style="font-size: 10pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3.69</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6.26</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">)</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold; text-decoration: underline"><div style="display: inline; text-decoration: underline;">Years Ended December 31,</div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center">(As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 68%; text-align: left">Statutory tax rate</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(21.0</div></td> <td style="width: 1%; text-align: left">)%</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(34.0</div></td> <td style="width: 1%; text-align: left">)%</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">State taxes, net of federal tax benefit</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Stock-based compensation</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Federal R&amp;D credit</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(0.6</div></td> <td style="text-align: left">)%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(0.2</div></td> <td style="text-align: left">)%</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Derivative liability</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.3</div></td> <td style="text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13.9</div></td> <td style="text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Nondeductible interest</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1.0</div></td> <td style="text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3.0</div></td> <td style="text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Other</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(0.1</div></td> <td style="text-align: left">)%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(0.2</div></td> <td style="text-align: left">)%</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Foreign losses</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">0.9</div></td> <td style="text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8.5</div></td> <td style="text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Change in U.S. federal tax rate</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25.1</div></td> <td style="text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">IRC Section 382 limitation</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7.2</div></td> <td style="text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Change in valuation allowance</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15.5</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">%</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(18.6</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)%</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Effective income tax rate</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">%</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.7</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">%</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">Years Ended December 31, </div></div><br /> <div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; text-decoration: underline;">(In thousands)</div></div></div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 62%; text-align: left">Research and development</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 16%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,797</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 16%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,204</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Sales, general and administrative</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,393</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,061</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Total stock-based compensation expense</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,190</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,265</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold">December 31,<br /> (In thousands)</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="text-align: center"><div style="display: inline; font-weight: bold;">(As Restated, Note 2)</div></td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 56%; text-align: left">United States</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 19%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,111</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 19%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,357</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Brazil</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,447</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,357</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Europe</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">198</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">178</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19,756</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,892</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;" cellspacing="0" cellpadding="0"> <tr style="vertical-align: bottom"> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="12" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">December 31, 2017</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; font-weight: bold">&nbsp;</td> </tr> <tr style="vertical-align: bottom"> <td style="font-size: 10pt; padding-bottom: 1pt">(In thousands)</td> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="2" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">As Previously Reported</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; font-weight: bold">&nbsp;</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="2" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Corrections</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; font-weight: bold">&nbsp;</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; font-weight: bold; text-align: center">Ref.</td> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="2" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">As Restated</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; font-weight: bold">&nbsp;</td> </tr> <tr style="vertical-align: bottom"> <td style="font-size: 10pt; font-weight: bold">Assets</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="2" style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="2" style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="2" style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Current assets:</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 57%; font-size: 10pt; text-align: left; padding-left: 10pt">Cash and cash equivalents</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 9%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,059</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 9%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 6%; font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 9%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,059</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Restricted cash</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,994</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,994</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Accounts receivable, net</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24,281</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(5,328</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">a</div></div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,953</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Accounts receivable - related party, net</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,340</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(4,573</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">a</div></div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,767</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Accounts receivable, unbilled - related party</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,901 </div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,901</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; padding-left: 10pt">Inventories</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,408</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,408</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt; padding-left: 10pt">Prepaid expenses and other current assets</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,525</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(606</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="padding-bottom: 1pt; font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">b</div></div></td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,919</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-left: 20pt">Total current assets</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">104,607</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(606</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">104,001</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Property, plant and equipment, net</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,892</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,892</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Accounts receivable, unbilled, noncurrent &#x2013; related party</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,940</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,940</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Restricted cash, noncurrent</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">959</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">959</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Recoverable taxes from Brazilian government entities</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,445</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,445</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt">Other assets</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">22,640</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(10,081</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="padding-bottom: 1pt; font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">c</div></div></td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,559</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-bottom: 2.5pt; padding-left: 20pt">Total assets</td> <td style="font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">151,483</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(10,687</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="padding-bottom: 2.5pt; font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">140,796</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; font-weight: bold; text-align: left">Liabilities, Mezzanine Equity and Stockholders' Deficit</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Current liabilities:</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Accounts payable</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15,921</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(406</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">d</div></div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15,515</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Accrued and other current liabilities</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29,402</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(200</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">e</div></div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29,202</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Contract liabilities</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,880</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(572</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">f</div></div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,308</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Debt, current portion</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">36,924</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">36,924</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt; padding-left: 10pt">Related party debt, current portion</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">20,019</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="padding-bottom: 1pt; font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">20,019</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-left: 20pt">Total current liabilities</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">107,146</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,178</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">105,968</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Long-term debt, net of current portion</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">61,893</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,673</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">g</div></div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60,220</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Related party debt, net of current portion</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">46,541</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">46,541</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Derivative liabilities</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">119,978</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,481</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">h</div></div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">116,497</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt">Other noncurrent liabilities</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,632</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,026</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="padding-bottom: 1pt; font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">i</div></div></td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,658</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt; padding-left: 20pt">Total liabilities</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">346,190</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,694</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="padding-bottom: 1pt; font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">352,884</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Commitments and contingencies</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Mezzanine equity:</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Contingently redeemable common stock</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,000</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,000</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Stockholders&#x2019; deficit:</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Preferred stock</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; padding-left: 10pt">Common stock - $0.0001 par value</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Additional paid-in capital</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,048,274</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">66,272</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">j</div></div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,114,546</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-left: 10pt">Accumulated other comprehensive loss</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(42,156</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(42,156</div></td> <td style="font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt; padding-left: 10pt">Accumulated deficit</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,206,767</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(83,653</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="padding-bottom: 1pt; font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">k</div></div></td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,290,420</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Total Amyris, Inc. stockholders&#x2019; deficit</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(200,644</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(17,381</div></td> <td style="font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(218,025</div></td> <td style="font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt">Noncontrolling interest</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">937</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;&nbsp;&nbsp;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="padding-bottom: 1pt; font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">937</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt">Total stockholders' deficit</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(199,707</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(17,381</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="padding-bottom: 1pt; font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(217,088</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-bottom: 2.5pt">Total liabilities, mezzanine equity and stockholders' deficit</td> <td style="font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">151,483</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(10,687</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="padding-bottom: 2.5pt; font-size: 10pt; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">140,796</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> </tr> </table></div><div style="display: inline; font-family: times new roman; font-size: 10pt"><table style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;" cellspacing="0" cellpadding="0"> <tr style="vertical-align: bottom"> <td style="text-align: left; vertical-align: top"></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="17" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Year Ended<br /> December 31, 2017</td> </tr> <tr style="vertical-align: bottom"> <td style="font-weight: bold">(In thousands, except shares and per share amounts)</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">As Previously Reported</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">Reclassifications<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(1)</div></div></div></td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Corrections</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">Ref</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">As Restated</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 46%; text-align: left; text-indent: -20pt; padding-left: 20pt">Renewable products</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">45,781</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,411</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">)</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 5%; text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,370</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Licenses and royalties</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,703</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,774</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(15,774</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">ab</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">48,703</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt; text-indent: -20pt; padding-left: 20pt">Grants and collaborations</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">39,960</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,363</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"></td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">36,598</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt; text-indent: -20pt; padding-left: 30pt">Total revenue</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">143,444</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(15,773</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">127,671</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Cost and operating expenses</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: -20pt; padding-left: 30pt">Cost of products sold</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">62,713</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(406</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">ad</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">62,307</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 30pt">Research and development</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,027</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(72</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">607</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">ae</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,562</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt; text-indent: -20pt; padding-left: 30pt">Sales, general and administrative</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">63,219</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">72</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">562</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">af</div></div></td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">63,853</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt; text-indent: -20pt; padding-left: 40pt">Total cost and operating expenses</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">182,959</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">763</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">183,722</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt; text-indent: -20pt; padding-left: 20pt">Loss from operations</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(39,515</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(16,536</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(56,051</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Other income (expense)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: -20pt; padding-left: 30pt">(Loss) gain on divestiture</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,732</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,732</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 30pt">Interest expense</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(34,033</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,048</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">ah</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(37,081</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: -20pt; padding-left: 30pt">(Loss) gain from change in fair value of derivative instruments</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,742</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(47,110</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">ai</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(48,852</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 30pt">Loss upon extinguishment of debt</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,521</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(10,376</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">ak</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(11,897</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt; text-indent: -20pt; padding-left: 30pt">Other income (expense), net</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(955</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(956</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt; text-indent: -20pt; padding-left: 40pt">Total other expense, net</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(32,519</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(60,535</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(93,054</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Loss before income taxes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(72,034</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(77,071</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(149,105</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt; text-indent: -20pt; padding-left: 20pt">Provision for income taxes</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(295</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,582</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">am</div></div></td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6,877</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Net loss attributable to Amyris, Inc.</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(72,329</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(83,653</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(155,982</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Less deemed dividend on capital distribution to related parties</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(8,648</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,648</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">an</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Less deemed dividend related to beneficial conversion feature on Series A preferred stock</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(562</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(562</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Less deemed dividend related to beneficial conversion feature on Series B preferred stock</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(634</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(634</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Less deemed dividend related to beneficial conversion feature on Series D preferred stock</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(5,757</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(5,757</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Less deemed dividend upon settlement of make-whole provision on Series A preferred stock</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(10,505</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">ap</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(10,505</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Less deemed dividend upon settlement of make-whole provision on Series B preferred stock</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(22,632</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">aq</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(22,632</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series A preferred stock</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(21,578</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">ar</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(21,578</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series B preferred stock</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(24,366</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">as</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(24,366</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Less cumulative dividends on Series A and Series B preferred stock</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(5,439</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,439</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">aw</div></div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt; text-indent: -20pt; padding-left: 20pt">Add: losses allocated to participating securities</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">40,159</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"><div style="display: inline; font-size: 10pt">au</div></div></td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">40,159</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 2.5pt; text-indent: -20pt; padding-left: 20pt">Net loss attributable to Amyris, Inc. common stockholders</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(93,369</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">)</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(108,488</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(201,857</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-indent: -20pt; padding-left: 20pt">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Net loss per share attributable to common stockholders</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt; padding-left: 10pt">Basic and diluted</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2.89</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(6.26</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: -20pt; padding-left: 20pt">Weighted-average shares of common stock outstanding used in computing loss per share of common stock:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt; padding-left: 10pt">Basic and diluted</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">32,253,570</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: center"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">32,253,570</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div><div style="display: inline; font-family: times new roman; font-size: 10pt"><table style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;" cellspacing="0" cellpadding="0"> <tr style="vertical-align: bottom"> <td style="text-indent: 10pt">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="11" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Year Ended December 31, 2017</td> </tr> <tr style="vertical-align: bottom"> <td style="font-weight: bold; text-decoration: underline; text-indent: 0pt"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">As Previously Reported</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Corrections<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(1)</div></td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">As Restated</td> </tr> <tr style="vertical-align: bottom"> <td style="text-indent: 10pt">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-weight: bold; text-align: left; text-indent: 0pt">Operating activities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 61%; text-align: left; text-indent: 0pt">Net loss</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(72,329</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">)</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(83,653</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">)</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(155,982</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 0pt">Adjustments to reconcile net loss to net cash used in operating activities:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Depreciation and amortization</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,358</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,358</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">(Gain) loss on disposal of property, plant and equipment</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">142</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">142</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Stock-based compensation</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,265</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,265</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Amortization of debt discount</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,490</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,749</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15,239</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">(Gain) loss upon extinguishment of debt</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,521</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,376</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,897</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Receipt of equity in connection with collaboration arrangements revenue</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,661</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,661</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">(Gain) loss from change in fair value of derivative liabilities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,742</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">47,110</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">48,852</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">(Gain) loss on foreign currency exchange rates</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,230</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,230</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Noncash revenue reduction related to issuance of debt obligations</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,413</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,413</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Non-cash gain on divestiture</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(5,732</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(5,732</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Receipt of noncash consideration in connection with license revenue</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(8,046</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(8,046</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Changes in assets and liabilities:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 20pt">Accounts receivable</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(19,647</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(19,647</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 20pt"><div style=" text-align: left; text-indent: 20pt">Accounts receivable, unbilled &#x2013; related party</div> </td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(7,940</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(7,940</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 20pt">Inventories</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,126</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,126</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 20pt">Prepaid expenses and other assets</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(19,336</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(18,730</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 20pt">Accounts payable</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,858</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(406</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,452</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 20pt">Accrued and other liabilities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,295</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,582</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,877</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 20pt">Contract liabilities</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(7,241</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(7,241</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 30pt">Net cash used in operating activities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(100,617</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(562</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(101,179</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-weight: bold; text-align: left; text-indent: 0pt">Investing activities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Proceeds from divestiture</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">54,827</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">54,827</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Change in short-term investments</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">712</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">581</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,293</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Change in restricted cash</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">865</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(865</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Purchases of property, plant and equipment</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(4,412</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(4,412</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 20pt">Net cash (used in) provided by investing activities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">51,992</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(284</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">51,708</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-weight: bold; text-align: left; text-indent: 0pt">Financing activities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Proceeds from issuance of convertible preferred stock</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">101,124</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,878</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">98,246</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Proceeds from exercises of common stock options</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">160</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(160</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Payment of minimum employee taxes withheld upon net share settlement of restricted stock units</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(385</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(385</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Proceeds from issuance of common stock in August 2017 offering</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,759</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,759</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Issuance costs incurred</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,159</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(2,159</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Change in restricted cash related to contingently redeemable common stock</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,046</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,046</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Proceeds from issuance of debt, net of issuance costs</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,925</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,925</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Principal payments on debt</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(37,500</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(37,500</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Payment of swap termination</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,113</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(3,113</div></td> <td style="white-space: nowrap; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Payment on early redemption of debt</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,909</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,909</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 20pt">Net cash provided by financing activities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">78,348</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(484</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">77,864</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 0pt">Effect of exchange rate changes on cash, cash equivalents and restricted cash</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">186</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">186</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Net (decrease) increase in cash, cash equivalents and restricted cash</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29,909</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,330</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28,579</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Cash, cash equivalents and restricted cash at beginning of year</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">27,150</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,283</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">32,433</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Cash, cash equivalents and restricted cash at end of year</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,059</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,953</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">61,012</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-indent: 10pt">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-weight: bold; text-align: left; text-indent: 0pt">Reconciliation of cash, cash equivalents and restricted cash to the consolidated balance sheets</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Cash and cash equivalents</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,059</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Restricted cash, current</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,994</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Restricted cash, noncurrent</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">959</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Total cash, cash equivalents and restricted cash</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">61,012</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-indent: 10pt">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-weight: bold; text-align: left; text-indent: 0pt">Supplemental disclosures of cash flow information:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 0pt">Cash paid for interest</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,539</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,539</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-weight: bold; text-align: left; text-indent: 0pt">Supplemental disclosures of non-cash investing and financing activities:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 0pt">Issuance of common stock upon conversion of debt</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28,702</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28,702</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 0pt">Accrued interest added to debt principal</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,816</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,816</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 0pt">Issuance of common stock for settlement of debt principal and interest payments</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,436</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,436</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 0pt">Financing of insurance premium under note payable</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">467</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">467</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 0pt">Issuance of convertible preferred stock upon conversion of debt</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">40,204</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">40,204</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 0pt">Settlement of debt principal by a related party</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 0pt">Issuance of note payable in exchange for debt extinguishment with third party</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,954</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,954</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 0pt">Issuance of common stock for settlement of debt</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,708</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,708</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 0pt">Issuance of preferred stock attributed to derivative liabilities</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">72,725</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">72,725</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">December 31,<br /> (In thousands)</td> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="15" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="15" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017 (As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom"> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Level&nbsp;1</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Level 2</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Level&nbsp;3</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total</td> <td style="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Level&nbsp;1</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Level 2</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Level&nbsp;3</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; font-weight: bold">Assets</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; width: 36%">Money market funds</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 5%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 5%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 5%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 5%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 5%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">53,199</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 5%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 5%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 5%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">53,199</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; padding-bottom: 1pt">Certificates of deposit</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,153</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,153</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Total assets measured and recorded at fair value</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">53,199</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,153</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,352</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; font-weight: bold">Liabilities</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">6% Convertible Notes Due 2021</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,918</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">57,918</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">$</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Embedded derivatives in connection with the issuance of debt and equity instruments</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">723</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">723</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; padding-bottom: 1pt">Freestanding derivative instruments in connection with the issuance of equity instruments</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,796</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,796</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">115,774</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">115,774</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left; padding-bottom: 2.5pt; text-indent: 10pt">Total liabilities measured and recorded at fair value</td> <td style="font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100,714</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100,714</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">116,497</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">116,497</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold"><div style="display: inline; font-size: 10pt"><div style="display: inline; font-weight: bold;">Years Ended December 31, <br /> <div style="display: inline; text-decoration: underline;">(In thousands)</div></div></div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center">(As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 68%; text-align: left">United States</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(218,109</div></td> <td style="width: 1%; text-align: left">)</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(156,020</div></td> <td style="width: 1%; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Foreign</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(12,125</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,915</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Loss before income taxes</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(230,234</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">)</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(149,105</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">)</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold">December 31,<br /> (In thousands)</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="text-align: center"><div style="display: inline; font-weight: bold;">(As Restated, Note 2)</div></td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 66%; text-align: left">Raw materials</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,901</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">819</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Work in process</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">539</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">364</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Finished goods</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,253</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,225</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Total inventories</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,693</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,408</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="11" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Year Ended December 31, 2018</td> </tr> <tr style="vertical-align: bottom"> <td style="font-weight: bold; border-bottom: Black 1pt solid">(In thousands)</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">As Reported</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Adjustments</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Amounts Without the Adoption of ASC 606</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 52%; text-align: left">Renewable products</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">33,598</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">33,598</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Licenses and royalties</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,658</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,094</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,752</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt">Grants and collaborations</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">22,348</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(5,786</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,562</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt">Total revenue from all customers</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">63,604</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(692</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">)</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">62,912</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold">December 31,<br /> (In thousands)</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center">(As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 66%; text-align: left">Contingent consideration</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,286</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,150</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Deposits</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,465</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,462</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Other</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,207</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,947</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-left: 10pt">Total other assets</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,958</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,559</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Number of <br /> Stock <br /> Options</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Weighted-<br /> average <br /> Exercise <br /> Price</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; text-align: center; border-bottom: Black 1pt solid"><div style="display: inline; font-weight: bold;">Weighted-average <br /> Remaining <br /> Contractual <br /> Life</div> <br /> (in years)</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; text-align: center; border-bottom: Black 1pt solid"><div style="display: inline; font-weight: bold;">Aggregate <br /> Intrinsic <br /> Value</div> <br /> (in thousands)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 48%">Outstanding - December 31, 2017</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,338,367</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">33.40</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7.7</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">97</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Options granted</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,337,119</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.18</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Options exercised</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(70,807</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3.68</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Options forfeited or expired</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(214,409</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19.61</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Outstanding - December 31, 2018</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,390,270</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11.55</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8.5</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Vested or expected to vest after December 31, 2018</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,833,615</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12.28</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8.4</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Exercisable at December 31, 2018</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">972,229</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">39.73</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.8</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold">Stock Option Award with Performance and Market Vesting Conditions:</td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 84%; text-align: left">Fair value of the Company&#x2019;s common stock on grant date</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.08</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Expected volatility</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">70</div></td> <td style="white-space: nowrap; text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Risk-free interest rate</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2.75</div></td> <td style="white-space: nowrap; text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Dividend yield</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">0.0</div></td> <td style="white-space: nowrap; text-align: left">%</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold">Years Ended December 31,</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Expected dividend yield</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;%</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;%</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 74%; text-align: left">Risk-free interest rate</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2.8</div></td> <td style="white-space: nowrap; width: 5%; text-align: left">%</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 6%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2.1</div></td> <td style="white-space: nowrap; width: 5%; text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Expected term (in years)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6.90</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6.12</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Expected volatility</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">80</div></td> <td style="white-space: nowrap; text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">84</div></td> <td style="white-space: nowrap; text-align: left">%</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Number of <br /> Restricted <br /> Stock Units</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Weighted-<br /> average <br /> Grant-date<br /> Fair Value</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Weighted-<br /> average <br /> Remaining <br /> Contractual<br /> Life<br /> (in years)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 58%">Outstanding - December 31, 2017</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">683,554</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8.66</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1.4</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Awarded</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,452,664</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.36</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Vested</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(445,828</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8.43</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Forfeited</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(395,587</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.64</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&nbsp;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Outstanding - December 31, 2018</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,294,803</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.50</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1.7</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">&nbsp;Vested or expected to vest after December 31, 2018</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,953,264</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.50</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1.6</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; border-bottom: Black 1pt solid">Transaction</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Number Outstanding as of <br /> December 31, 2017</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Additional <br /> Warrants Issued</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Exercises</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Number Outstanding as of <br /> December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 52%">August 2018 warrant exercise agreements</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,097,164</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,097,164</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">May 2017 cash and dilution warrants</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,042,568</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(11,749,770</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,292,798</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">August 2017 cash and dilution warrants</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,543,234</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,713,565</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(7,288,683</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,968,116</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>April 2018 warrant exercise agreements</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,616,174</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,616,174</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">July 2015 related party debt exchange</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,082,010</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">471,204</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,889,986</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">663,228</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">February 2016 related party private placement</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">171,429</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">171,429</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>July 2015 private placement</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">81,197</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">81,197</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Other</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,406</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,406</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29,921,844</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">17,898,107</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(20,928,439</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">)</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">26,891,512</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; text-decoration: underline"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td>&nbsp;</td> <td colspan="3" style="white-space: nowrap">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 84%">Balance at December&nbsp;31, 2016</td> <td style="width: 1%">&nbsp;</td> <td style="text-align: left; width: 1%">$</td> <td style="text-align: right; width: 13%"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,101</div></td> <td style="white-space: nowrap; text-align: left; width: 1%">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Increases in tax positions for prior period</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Increases in tax positions during current period</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19,682</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Balance at December&nbsp;31, 2017</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28,833</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Increases in tax positions for prior period</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">55</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Increases in tax positions during current period</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,239</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Balance at December&nbsp;31, 2018</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">30,127</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;" cellspacing="0" cellpadding="0" align="center"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; border-bottom: Black 1pt solid">As of December 31,</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 60%; text-align: left">Customer B</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24</div></td> <td style="white-space: nowrap; width: 8%; text-align: left">%</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div></td> <td style="white-space: nowrap; width: 8%; text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Customer C</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19</div></td> <td style="white-space: nowrap; text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15</div></td> <td style="white-space: nowrap; text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Customer G </td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11</div></td> <td style="white-space: nowrap; text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">**</div></td> <td style="white-space: nowrap; text-align: left"></td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Customer A (related party)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">**</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">38</div></td> <td style="white-space: nowrap; text-align: left">%</td> </tr> </table></div><div style="display: inline; font-family: times new roman; font-size: 10pt"><table style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;" cellspacing="0" cellpadding="0" align="center"> <tr style="vertical-align: bottom"> <td style="font-weight: bold; border-bottom: Black 1pt solid">Years Ended December 31,</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center">(As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 60%; text-align: left">Customer A (related party)</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">17</div></td> <td style="width: 8%; text-align: left">%</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">46</div></td> <td style="width: 8%; text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Customer B</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18</div></td> <td style="text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div></td> <td style="text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Customer C</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div></td> <td style="text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">**</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Customer D</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div></td> <td style="text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">**</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Customer E</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">**</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11</div></td> <td style="text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Customer F</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">**</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">**</td> <td style="text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font-size: 10pt; text-align: justify; text-indent: -27pt; margin: 0pt 0 0pt 27pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15.</div> Geographical Information</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The chief operating decision maker is the Company's Chief Executive Officer, who makes resource allocation decisions and assesses performance based on financial information presented on a consolidated basis. There are <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> segment managers who are held accountable by the chief operating decision maker, or anyone else, for operations, operating results, and planning for levels or components below the consolidated unit level. Accordingly, the Company has determined that it has a single reportable segment and operating segment structure.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 12pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Revenue</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Revenue by geography, based on each customer's location, is shown in Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> "Revenue Recognition".</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 12pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">&nbsp;</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 12pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Property, Plant and Equipment</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 12pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold">December 31,<br /> (In thousands)</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="text-align: center"><div style="display: inline; font-weight: bold;">(As Restated, Note 2)</div></td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 56%; text-align: left">United States</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 19%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,111</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 19%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,357</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Brazil</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,447</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,357</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Europe</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">198</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">178</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19,756</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,892</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div></div> 90902000 63853000 63219000 72000 562000 9190000 6265000 6265000 P3Y P5Y P5Y 395587 5.64 5294803 683554 5452664 5.36 5.51 683554 5294803 8.66 5.50 P1Y146D P1Y255D 445828 8.43 0 0.7 0.8 0.84 0.0275 0.028 0.021 4000000 9000000 1000000 2000000 1666666 2359750 252107 9280000 0 382824 80594 972229 39.73 200000 0 5452664 523167 214409 4337119 661094 5.18 3.26 97000 29000 5339214 1255045 52389 79322 1338367 5390270 33.40 26.29 185.93 144.58 33.40 11.55 28000 4833615 12.28 3.68 19.61 5.18 17.10 2.10 1000 1000 23.40 3.34 3.75 P6Y328D P6Y43D 12000 P5Y292D P7Y255D P8Y182D P8Y146D 0.85 3.68 4.41 6.90 4.26 2.87 5.12 4.02 4.76 4.02 4.02 76564829 18273921 22171 45637433 14656 76564829 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1.</div> Basis of Presentation and Summary of Significant Accounting Policies</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;">&nbsp;</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;">Business Description</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Amyris, Inc. (Amyris or the Company) is a leading industrial biotechnology company that applies its technology platform to engineer, manufacture and sell high performance, natural, sustainably-sourced products into the Health &amp; Wellness, Clean Beauty, and Flavor &amp; Fragrance markets. The Company's proven technology platform enables the Company to rapidly engineer microbes and use them as catalysts to metabolize renewable, plant-sourced sugars into large volume, high-value ingredients. The Company's biotechnology platform and industrial fermentation process replace existing complex and expensive manufacturing processes. The Company has successfully used its technology to develop and produce several distinct molecules at commercial volumes.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;">Going Concern</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company has incurred significant operating losses since its inception and expects to continue to incur losses and negative cash flows from operations for at least the next <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12</div> months following the issuance of the financial statements. As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> the Company had negative working capital of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$119.5</div> million and an accumulated deficit of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.5</div> billion.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> the Company's debt (including related party debt), net of deferred discount and issuance costs of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$17.1</div> million and a change in fair value of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.1</div> million, totaled <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$209.7</div> million, of which <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$147.7</div> million is classified as current. The Company's debt agreements contain various covenants, including certain restrictions on the Company's business that could cause the Company to be at risk of defaults, such as restrictions on additional indebtedness, material adverse effect and cross default clauses. A failure to comply with the covenants and other provisions of the Company&#x2019;s debt instruments, including any failure to make a payment when required, would generally result in events of default under such instruments, which could permit acceleration a substantial portion of such indebtedness. If such indebtedness is accelerated, it would generally also constitute an event of default under the Company&#x2019;s other outstanding indebtedness, permitting acceleration of a substantial portion of such other outstanding indebtedness. At <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018, </div>the Company failed to meet certain covenants in connection with the GACP Term Loan Facility (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> &#x201c;Debt&#x201d;), including those associated with minimum revenue and minimum liquidity requirements. In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 2019, (</div>i) GACP provided a waiver to the Company for breaches of all covenant violations under the GACP loan and security agreement (LSA) occurring prior to, as of and after <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018 </div>through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 8, 2019, </div>and (ii) GACP sold and assigned the loans under the LSA and all documents and assets related thereto to Foris Ventures, LLC (Foris). Subsequently, Foris provided a waiver to the Company for breaches of certain covenants under the LSA through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 30, 2020 </div>and amended the financial covenants under the LSA to provide more favorable compliance terms and conditions. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> "Subsequent Events" for additional information.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Cash and cash equivalents of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$45.4</div> million as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> are <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> sufficient to fund expected future negative cash flows from operations and cash debt service obligations through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">30,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2020.</div> These factors raise substantial doubt about the Company&#x2019;s ability to continue as a going concern within <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> year after the date that these financial statements are issued. The consolidated financial statements do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> include any adjustments that might result from the outcome of this uncertainty. The Company's ability to continue as a going concern will depend, in large part, on its ability to achieve positive cash flows from operations during the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12</div> months from the date of this filing, and refinance or extend other existing debt maturities occurring later in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> all of which are uncertain and outside the control of the Company. Further, the Company's operating plan for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> contemplates a significant reduction in its net operating cash outflows as compared to the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> resulting from (i) revenue growth from sales of existing and new products with positive gross margins, (ii) reduced production costs as a result of manufacturing and technical developments, and (iii) an increase in cash inflows from collaborations and grants. If the Company is unable to complete these actions, it expects to be unable to meet its operating cash flow needs and its obligations under its existing debt facilities. This could result in an acceleration of its obligation to repay all amounts outstanding under those facilities, and the Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be forced to obtain additional equity or debt financing, which <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> occur timely or on reasonable terms, if at all, and/or liquidate its assets. In such a scenario, the value received for assets in liquidation or dissolution could be significantly lower than the value reflected in these financial statements. The Company has in the past, including in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2019, </div>had certain of its debt instruments accelerated for failure to make a payment when due. While we have been able to cure these defaults to date to avoid additional cross-acceleration, we <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> be able to cure such a default promptly in the future.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 16, 2019, </div>the Company failed to pay an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$63.6</div> million of outstanding principal and accrued interest on the Second Exchange Note when due. The failure resulted in an event of default under the Second Exchange Note and also triggered cross-defaults under other debt instruments of the Company which permitted the holders of such indebtedness to accelerate the amounts owing under such instruments. The Company subsequently received waivers from substantially all holders of such other debt instruments to waive the right to accelerate. As a result, the indebtedness with respect to which the Company has obtained such waivers continues to be classified as long-term on the Company&#x2019;s balance sheet.&nbsp; The indebtedness reflected by the Second Exchange Note continues to be classified as a current liability on the Company&#x2019;s balance sheet. In addition, as a result of the payment default, the conversion price of the Second Exchange Note is subject to adjustment in accordance with the terms of the Second Exchange Note.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> currently have sufficient funds to repay the amounts outstanding under the Second Exchange Note. To date, negotiations with the holder of the Second Exchange Note have <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> been successful, and there can be <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> assurance that a favorable outcome for the Company will be reached. The Company has executed a term sheet with an existing investor for a term loan, the proceeds of which would be used to repay a portion of the Second Exchange Note. However, there can be <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> assurance that the Company will be able to obtain such financing on its expected timeline, or on acceptable terms, if at all. Even if the Company does obtain such financing, it will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> have sufficient funds to repay the Second Exchange Note in full without obtaining additional financing, which the Company is attempting to source. The consolidated financial statements do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> include any adjustments that might result from the outcome of this uncertainty.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;">Basis of Consolidation</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The accompanying consolidated financial statements have been prepared in accordance with the accounting principles generally accepted in the United States (U.S. GAAP). The consolidated financial statements include the accounts of Amyris, Inc. and its wholly-owned and partially-owned subsidiaries in which the Company has a controlling interest after elimination of all significant intercompany accounts and transactions.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Investments and joint venture arrangements are assessed to determine whether the terms provide economic or other control over the entity requiring consolidation of the entity. Entities controlled by means other than a majority voting interest are referred to as variable-interest entities (VIEs) and are consolidated when Amyris has both the power to direct the activities of the VIE that most significantly impact its economic performance and the obligation to absorb losses or the right to receive benefits that could potentially be significant to the entity. For any investment or joint venture in which (i) the Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> have a majority ownership interest, (ii) the Company possesses the ability to exert significant influence and (iii) the entity is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> a VIE for which the Company is considered the primary beneficiary, the Company accounts for the investment or joint venture using the equity method. Following the adoption of ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">01</div> on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018 </div>described in more detail below (which was applicable to the Company on a prospective basis), equity investments in which the Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> exert significant influence and that do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> have readily determinable fair values are measured at cost, adjusted for changes from observable market transactions, less impairment (&#x201c;adjusted cost basis&#x201d;). The Company evaluates its investments for impairment by considering a variety of factors, including the earnings capacity of the related investments. Fair value measurements for the Company&#x2019;s equity investments are classified within Level <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div> of the fair value hierarchy based on the nature of the fair value inputs. Realized and unrealized gains or losses are recognized in other income or expense.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;">Sale of Subsidiary and Entry into Commercial Agreements</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 28, 2017, </div>the Company completed the sale of all of the capital stock of its subsidiary Amyris Brasil, a wholly-owned subsidiary, to DSM Produtos Nutricionais Brasil S.A (DSM), a related party. Amyris Brasil owned and operated the Company&#x2019;s production facility in Brotas, Brazil. The transaction resulted in a pretax gain of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.7</div> million from continuing operations in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> which was further adjusted by a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.8</div> million loss in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> related to the final working capital adjustments between the Company and DSM. The transaction did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> result in presenting Amyris Brasil as a discontinued operation in the consolidated financial statements, as the sale did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> represent a strategic shift that will have a major effect on the Company&#x2019;s operations and financial results due to the Company&#x2019;s continuing commercial presence and reinvestment in a new production facility under construction in Brazil and its continuing Brazilian operation through Amyris Biotecnologia do Brasil Ltda. (formerly SMA Ind&uacute;stria Qu&iacute;mica Ltda.). The Company and DSM also entered into a series of commercial agreements and a credit agreement concurrently with the sale of Amyris Brasil. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> &#x201c;Revenue Recognition&#x201d;, Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,</div> &#x201c;Related Party Transactions&#x201d;, Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,</div> &#x201c;Divestiture&#x201d; and Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> &#x201c;Subsequent Events&#x201d; for further information.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;">Use of Estimates and Judgements</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates, judgements and assumptions that affect the reported amounts of assets and liabilities, disclosures of contingent assets and liabilities at the date of the financial statements, and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates, and such differences <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be material to the consolidated financial statements.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-align: justify"></div> <!-- Field: /Page --> <div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27pt; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;">Significant Accounting Policies</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Cash and Cash Equivalents</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The Company considers all highly liquid investments purchased with an original or remaining maturity of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> months or less at the date of purchase to be cash equivalents. Cash and cash equivalents are maintained with various financial institutions.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Inventories</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Inventories, which consist of farnesene-derived products, flavors and fragrances ingredients and clean beauty products, are stated at the lower of actual cost or net realizable value and are categorized as finished goods, work in process or raw material inventories. The Company evaluates the recoverability of its inventories based on assumptions about expected demand and net realizable value. If the Company determines that the cost of inventories exceeds their estimated net realizable value, the Company records a write-down equal to the difference between the cost of inventories and the estimated net realizable value. If actual net realizable values are less favorable than those projected by management, additional inventory write-downs <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be required that could negatively impact the Company's operating results. If actual net realizable values are more favorable, the Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>have favorable operating results when products that have been previously written down are sold in the normal course of business. The Company also evaluates the terms of its agreements with its suppliers and establishes accruals for estimated losses on adverse purchase commitments as necessary, applying the same lower of cost or net realizable value approach that is used to value inventory. Cost is computed on a weighted-average basis.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 12pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Property, Plant and Equipment, Net</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Property, plant and equipment are recorded at cost. Depreciation and amortization are computed straight-line based on the estimated useful lives of the related assets, ranging from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div> to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15</div> years for machinery, equipment and fixtures, and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15</div> years for buildings. Leasehold improvements are amortized over their estimated useful lives or the period of the related lease, whichever is shorter.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The Company expenses costs for maintenance and repairs and capitalizes major replacements, renewals and betterments. For assets retired or otherwise disposed, both cost and accumulated depreciation are eliminated from the asset and accumulated depreciation accounts, and gains or losses related to the disposal are recorded in the statement of operations for the period.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Impairment</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Long-lived assets that are held and used by the Company are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount of such assets <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> be recoverable. Determination of recoverability of long-lived assets is based on an estimate of the undiscounted future cash flows resulting from the use of the asset and its eventual disposition. Measurement of an impairment loss for long-lived assets that management expects to hold and use is based on the difference between the fair value of the asset and its carrying value. Long-lived assets to be disposed of are reported at the lower of carrying amount or fair value less costs to sell.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div></div> <!-- Field: /Page --> <div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;"></div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Recoverable Taxes from Brazilian Government Entities</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Recoverable taxes from Brazilian government entities represent value-added taxes paid on purchases in Brazil, which are reclaimable from the Brazilian tax authorities, net of reserves for amounts estimated <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> to be recoverable.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Fair Value Measurements</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The carrying amounts of certain financial instruments, such as cash equivalents, short-term investments, accounts receivable, accounts payable and accrued liabilities, approximate fair value due to their relatively short maturities.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The Company measures the following financial assets and liabilities at fair value:</div> <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; min-width: 700px;" cellspacing="0" cellpadding="0"> <tr style="vertical-align: top"> <td style="width: 27pt"></td> <td style="width: 18pt">&#x2022;</td> <td>Freestanding and bifurcated derivatives in connection with certain debt and equity financings; and</td> </tr> </table> <table style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; min-width: 700px;" cellspacing="0" cellpadding="0"> <tr style="vertical-align: top"> <td style="width: 27pt"></td> <td style="width: 18pt">&#x2022;</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,</div> "Fair Value Measurement", Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> "Debt" and Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> &#x201c;Subsequent Events&#x201d;), for which the Company has elected fair value accounting</td> </tr> </table> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Fair value is based on the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants. Where available, fair value is based on or derived from observable market prices or other observable inputs. Where observable prices or inputs are <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> available, valuation techniques are applied. These valuation techniques involve some level of management estimation and judgement, the degree of which is dependent on the price transparency for the instruments or market and the instruments&#x2019; complexity.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Changes to the inputs used in these valuation models have a significant impact on the estimated fair value of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> and the Company's embedded and freestanding derivatives. For example, a decrease (increase) in the estimated credit spread for the Company results in an increase (decrease) in estimated fair value. Conversely, a decrease (increase) in the stock price results in a decrease (increase) in estimated fair value.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The changes during <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div> in the fair values of the bifurcated compound embedded derivatives are primarily related to the change in price of the Company's common stock and are reflected in the consolidated statements of operations as &#x201c;Gain (loss) from change in fair value of derivative instruments&#x201d;.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">For debt instruments for which the Company has <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> elected fair value accounting, fair value is based on the present value of expected future cash flows and assumptions about the then-current market interest rates as of the reporting period and the creditworthiness of the Company. Most of the Company's debt is carried on the consolidated balance sheet on a historical cost basis net of unamortized discounts and premiums, because the Company has <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> elected the fair value option of accounting. However, for the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021,</div> the Company elected fair value accounting, so that balances reported for that debt instrument represent fair value as of each balance sheet date; see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,</div> "Fair Value Measurement", for additional information. Changes in fair value of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes Due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> are reflected in the consolidated statements of operations as &#x201c;Gain (loss) from change in fair value of debt&#x201d;.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">For all debt instruments, including any for which the Company has elected fair value accounting, the Company classifies interest that has been accrued during each period as Interest expense on the consolidated statements of operations.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Derivatives</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Embedded derivatives that are required to be bifurcated from the underlying debt instrument (i.e., host) are accounted for and valued as separate financial instruments. The Company has evaluated the terms and features of its convertible notes payable and convertible preferred stock and identified compound embedded derivatives requiring bifurcation and accounting at fair value, using the valuation techniques mentioned in the <div style="display: inline; font-style: italic;">Fair Value Measurements</div> section of this Note, because the economic and contractual characteristics of the embedded derivatives met the criteria for bifurcation and separate accounting due to the instruments containing conversion options, certain &#x201c;make-whole interest&#x201d; provisions, down-round conversion price adjustment provisions and/or conversion rate adjustments.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> </div> <!-- Field: Page; Sequence: 17; Value: 1 --> <!-- Field: /Page --> <div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Cash warrants and anti-dilution warrants issued in conjunction with the convertible debt and equity financings are freestanding financial instruments which are also classified as derivative liabilities.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Noncontrolling Interest</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Noncontrolling interests represent the portion of net income (loss), net assets and comprehensive income (loss) that is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> allocable to the Company, in situations where the Company consolidates its equity investment in a joint venture for which there are other owners. The amount of noncontrolling interest is comprised of the amount of such interests at the date of the Company's original acquisition of an equity interest in a joint venture, plus the other shareholders' share of changes in equity since the date the Company made an investment in the joint venture.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 12pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Concentration of Credit Risk</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Financial instruments that potentially subject the Company to a concentration of credit risk consist primarily of cash and cash equivalents, short-term investments and accounts receivable. The Company places its cash equivalents and investments (primarily certificates of deposits) with high credit quality financial institutions and, by policy, limits the amount of credit exposure with any <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> financial institution. Deposits held with banks <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>exceed the amount of insurance provided on such deposits. The Company has <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> experienced any losses on its deposits of cash and cash equivalents and short-term investments.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The Company performs ongoing credit evaluation of its customers, does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> require collateral, and maintains allowances for potential credit losses on customer accounts when deemed necessary.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Customers representing <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10%</div> or greater of accounts receivable were as follows:</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div> <table style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;" cellspacing="0" cellpadding="0" align="center"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; border-bottom: Black 1pt solid">As of December 31,</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 60%; text-align: left">Customer B</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">24</div></td> <td style="white-space: nowrap; width: 8%; text-align: left">%</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div></td> <td style="white-space: nowrap; width: 8%; text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Customer C</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19</div></td> <td style="white-space: nowrap; text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15</div></td> <td style="white-space: nowrap; text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Customer G </td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11</div></td> <td style="white-space: nowrap; text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">**</div></td> <td style="white-space: nowrap; text-align: left"></td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Customer A (related party)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">**</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">38</div></td> <td style="white-space: nowrap; text-align: left">%</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">______________</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-size: 8pt">** Less than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10%</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: -0.25in"><div style="display: inline; font-style: italic;">&nbsp;</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Customers representing <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10%</div> or greater of revenue were as follows:</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div> <table style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;" cellspacing="0" cellpadding="0" align="center"> <tr style="vertical-align: bottom"> <td style="font-weight: bold; border-bottom: Black 1pt solid">Years Ended December 31,</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center">(As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 60%; text-align: left">Customer A (related party)</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">17</div></td> <td style="width: 8%; text-align: left">%</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">46</div></td> <td style="width: 8%; text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Customer B</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18</div></td> <td style="text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div></td> <td style="text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Customer C</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div></td> <td style="text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">**</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Customer D</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div></td> <td style="text-align: left">%</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">**</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Customer E</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">**</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11</div></td> <td style="text-align: left">%</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Customer F</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">**</td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">**</td> <td style="text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">______________</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-size: 8pt"></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-size: 8pt">** Less than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10%</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Revenue Recognition</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 7pt 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; text-decoration: underline;">Year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">For the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017, </div>the Company recognized revenue from the sale of renewable products, licenses of and royalties from intellectual property, and grants and collaborative research and development services. Revenue was recognized when all of the following criteria were met: persuasive evidence of an arrangement existed, delivery has occurred or services have been rendered, the fee was fixed or determinable, and collectability was reasonably assured. If sales arrangements contained multiple elements, the Company evaluated whether the components of each arrangement represent separate units of accounting.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">&nbsp;</div></div> </div> <!-- Field: Page; Sequence: 18; Value: 1 --> <!-- Field: /Page --> <div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-style: italic;"></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">&nbsp;</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Renewable Product Sales</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The Company&#x2019;s renewable product sales do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> include rights of return, except for sales of Biossance products. Returns are only accepted if the product does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> meet product specifications and such nonconformity is communicated to the Company within a set number of days of delivery. The Company offers a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div>-year standard warranty provision for squalane products, if the products do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> meet Company-established criteria as set forth in the Company&#x2019;s trade terms. The Company bases its return reserve on a historical rate of return for the Company&#x2019;s squalane products. Revenues are recognized, net of discounts and allowances, once passage of title and risk of loss has occurred and contractually specified acceptance criteria have been met, provided all other revenue recognition criteria have also been met.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Licenses and Royalties</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">License fees for intellectual property transferred to other parties, representing non-refundable payments received at the time of signature of license agreements, are recognized as revenue upon signature of the license agreements when the Company has <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> significant future performance obligations and collectability of the fees is assured. Upfront payments received at the beginning of licensing agreements with future service obligations are deferred and recognized as revenue on a systematic basis over the period during which the related services are rendered and all obligations are performed.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Royalties from intellectual property licenses that allow Amyris's customers to use the Company&#x2019;s intellectual property to produce and sell their products in which the Company shares in the profits are recognized in the period the royalty report is received.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Grants and Collaborative Research and Development Services</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Revenues from collaborative research and development services are recognized as the services are performed consistent with the performance requirements of the contract. In cases where the planned levels of research and development services fluctuate over the research term, the Company recognizes revenues using the proportional performance method based upon actual efforts to date relative to the amount of expected effort to be incurred by us. When up-front payments are received and the planned levels of research and development services do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> fluctuate over the research term, revenues are recorded on a ratable basis over the arrangement term, up to the amount of cash received. When up-front payments are received and the planned levels of research and development services fluctuate over the research term, revenues are recorded using the proportional performance method, up to the amount of cash received. Where arrangements include milestones that are determined to be substantive and at risk at the inception of the arrangement, revenues are recognized upon achievement of the milestone and is limited to those amounts whereby collectability is reasonably assured.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Grants are agreements that generally provide cost reimbursement for certain types of expenditures in return for research and development activities over a contractually defined period. Revenues from grants are recognized in the period during which the related costs are incurred, provided that the conditions under which the grants were provided have been met and only perfunctory obligations are outstanding.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;"></div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;"></div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018</div></div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">In accordance with a new revenue recognition standard that the Company adopted <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018, </div>the Company recognizes revenue from the sale of renewable products, licenses of and royalties from intellectual property, and grants and collaborative research and development services. Revenue is measured based on the consideration specified in a contract with a customer, and transaction price is allocated utilizing stand-alone selling price. Revenue is recognized when, or as, the Company satisfies a performance obligation by transferring control over a product or service to a customer. The Company generally does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> incur costs to obtain new contracts. The costs to fulfill a contract are expensed as incurred.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The Company accounts for a contract when it has approval and commitment to perform from both parties, the rights of the parties are identified, payment terms are established, the contract has commercial substance and collectability of the consideration is probable. Changes to contracts are assessed for whether they represent a modification or should be accounted for as a new contract. The Company considers the following indicators, among others, when determining if it is acting as a principal in the transaction and recording revenue on a gross basis: (i) the Company is primarily responsible for fulfilling the promise to provide the specified goods or service, (ii) the Company has inventory risk before the specified good or service has been transferred to a customer or after transfer of control to the customer and (iii) the Company has discretion in establishing the price for the specified good or service. If a transaction does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> meet the Company's indicators of being a principal in the transaction, then the Company is acting as an agent in the transaction and the associated revenues are recognized on a net basis.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> </div> <!-- Field: Page; Sequence: 19; Value: 1 --> <!-- Field: /Page --> <div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The Company&#x2019;s significant contracts and contractual terms with its customers are presented in Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> "Revenue Recognition".</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The Company recognizes revenue when control has passed to the customer. The following indicators are evaluated in determining when control has passed to the customer: (i) the Company has a right to receive payment for the product or service, (ii) the customer has legal title to the product, (iii) the Company has transferred physical possession of the product to the customer, (iv) the customer has the significant risk and rewards of ownership of the product and (v) the customer has accepted the product. For most of the Company's renewable products customers, supply agreements between the Company and each customer indicate when transfer of title occurs.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">In some cases, the Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>make a payment to a customer. When that occurs, the Company evaluates whether the payment is for a distinct good or service receivable from the customer. If the fair value of the goods or services receivable is greater than or equal to the amount paid to the customer, then the entire payment is treated as a purchase. If, on the other hand, the fair value of goods or services is less than the amount paid, then the difference is treated as a reduction in transaction price of the Company's sales to the customer.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Performance Obligations</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">A performance obligation is a promise in a contract to transfer a distinct good or service to the customer. A contract&#x2019;s transaction price is allocated to each distinct performance obligation and recognized as revenue when, or as, the performance obligation is satisfied. The Company's contracts <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>contain multiple performance obligations if a promise to transfer the individual goods or services is separately identifiable from other promises in the contracts and, therefore, is considered distinct. For contracts with multiple performance obligations, the Company determines the standalone selling price of each performance obligation and allocates the total transaction price using the relative selling price basis.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The following is a description of the principal goods and services from which the Company generates revenue.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Renewable Product Sales</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Revenues from renewable product sales are recognized as a distinct performance obligation on a gross basis as the Company is acting as a principal in these transactions, with the selling price to the customer recorded net of discounts and allowances. Revenues are recognized at a point in time when control has passed to the customer, which typically is upon the renewable products leaving the Company&#x2019;s facilities with the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> transportation carrier. The Company, on occasion, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>recognize revenue under a bill and hold arrangement, whereby the customer requests and agrees to purchase product but requests delivery at a later date. Under these arrangements, control transfers to the customer when the product is ready for delivery, which occurs when the product is identified separately as belonging to the customer, the product is ready for shipment to the customer in its current form, and the Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> have the ability to direct the product to a different customer. It is at this point that the Company has the right to receive payment, the customer obtains legal title, and the customer has the significant risks and rewards of ownership. The Company&#x2019;s renewable product sales do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> include rights of return, except for Biossance products, for which the Company estimates sales returns subsequent to sale and reduces revenue accordingly. For renewable products other than Biossance, returns are accepted only if the product does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> meet product specifications and such nonconformity is communicated to the Company within a set number of days of delivery. The Company offers a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div>-year assurance-type warranty to replace squalane products that do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> meet Company-established criteria as set forth in the Company&#x2019;s trade terms. An estimate of the cost to replace the squalane products sold is made based on a historical rate of experience and recognized as a liability and related expense when the renewable product sale is consummated.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> </div> <!-- Field: Page; Sequence: 20; Value: 1 --> <!-- Field: /Page --> <div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Licenses and Royalties</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Licensing of Intellectual Property: </div>When the Company&#x2019;s intellectual property licenses are determined to be distinct from the other performance obligations identified in the arrangement, revenue is recognized from non-refundable, up-front fees allocated to the license at a point in time when the license is transferred to the licensee and the licensee is able to use and benefit from the license. For intellectual property licenses that are combined with other promises, the Company utilizes judgment to assess the nature of the combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purposes of recognizing revenue from non-refundable, up-front-fees. The Company evaluates the measure of progress each reporting period and, if necessary, adjusts the measure of performance and related revenue recognized.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Royalties from Licensing of Intellectual Property:</div> The Company earns royalties from the licensing of its intellectual property whereby the licensee uses the intellectual property to produce and sell its products to its customers and the Company shares in the profits.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">When the Company&#x2019;s intellectual property license is the only performance obligation, or it is the predominant performance obligation in arrangements with multiple performance obligations, the Company applies the sales-based royalty exception which requires the Company to estimate the revenue that is recognized at a point in time when the licensee&#x2019;s product sales occur. Estimates of sales-based royalty revenues are made using the most likely outcome method, which is the single amount in a range of possible amounts, using the best evidence available at the time, derived from the licensee&#x2019;s historical sales volumes and sales prices of its products and recent commodity market pricing data and trends. Estimates are adjusted to actual or as new information becomes available.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">When the Company&#x2019;s intellectual property license is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> the predominant performance obligation in arrangements with multiple performance obligations, the royalty represents variable consideration and is allocated to the transaction price of the predominant performance obligation which generally is the supply of renewable products to the Company's customers. Revenue is estimated and recognized at a point in time when the renewable products are delivered to the customer. Estimates of the amount of variable consideration to include in the transaction price are made using the expected value method, which is the sum of probability-weighted amounts in a range of possible amounts determined based on the cost to produce the renewable product plus a reasonable margin for the profit share. The Company only includes an amount of variable consideration in the transaction price to the extent it is probable that a significant reversal in the cumulative revenue recognized will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> occur when the uncertainty associated with the variable consideration is subsequently resolved. Also, the transaction price is reduced for estimates of customer incentive payments payable by the Company for certain customer contracts.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Grants and Collaborative Research and Development Services</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Collaborative Research and Development Services:</div> The Company earns revenues from collaboration agreements with customers to perform research and development services to develop new molecules using the Company&#x2019;s technology and to scale production of the molecules for commercialization and use in the collaborator&#x2019;s products. The collaboration agreements generally include providing the Company's collaboration partners with research and development services and with licenses to the Company&#x2019;s intellectual property to use the technology underlying the development of the molecules and to sell its products that incorporate the technology. The terms of the Company's collaboration agreements typically include <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> or more of the following: advance payments for the research and development services that will be performed, nonrefundable upfront license payments, milestone payments to be received upon the achievement of the milestone events defined in the agreements, and royalty payments upon the commercialization of the molecules in which the Company shares in the customer&#x2019;s profits.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> </div> <!-- Field: Page; Sequence: 21; Value: 1 --> <div><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Collaboration agreements are evaluated at inception to determine whether the intellectual property licenses represent distinct performance obligations separate from the research and development services. If the licenses are determined to be distinct, the non-refundable upfront license fee is recognized as revenue at a point in time when the license is transferred to the licensee and the licensee is able to use and benefit from the license while the research and development service fees are recognized over time as the performance obligations are satisfied. The research and development service fees represent variable consideration. Estimates of the amount of variable consideration to include in the transaction price are made using the expected value method, which is the sum of probability-weighted amounts in a range of possible amounts. The Company only includes an amount of variable consideration in the transaction price to the extent it is probable that a significant reversal in the cumulative revenue recognized will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> occur when the uncertainty associated with the variable consideration is subsequently resolved. Revenue is recognized over time using either an input-based measure of labor hours expended or a time-based measure of progress towards the satisfaction of the performance obligations. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Collaboration agreements that include milestone payments are evaluated at inception to determine whether the milestone events are considered probable of achievement, and estimates are made of the amount of the milestone payments to include in the transaction price using the most likely amount method which is the single amount in a range of possible amounts. If it is probable that a significant revenue reversal will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> occur, the estimated milestone payment amount is included in the transaction price. Each reporting period, the Company re-evaluates the probability of achievement of the milestone events and any related constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative basis, which would affect collaboration revenues in the period of adjustment. Generally, revenue is recognized using an input-based measure of progress towards the satisfaction of the performance obligations which can be labor hours expended or time-based in proportion to the estimated total project effort or total projected time to complete. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized. Certain performance obligations are associated with milestones agreed between the Company and its customer. Revenue generated from the performance of services in accordance with these milestones is recognized upon confirmation from the customer that the milestone has been achieved. In these cases, amounts recognized are constrained to the amount of consideration received upon achievement of the milestone.&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The Company generally invoices its collaboration partners on a monthly or quarterly basis, or upon the completion of the effort or achievement of a milestone, based on the terms of each agreement. Deferred revenue arises from amounts received in advance of performing the research and development activities and is recognized as revenue in future periods as the performance obligations are satisfied.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt"><div style="display: inline; font-style: italic;">Grants:</div> The Company earns revenues from grants with government agencies to, among other things, provide research and development services to develop molecules using the Company&#x2019;s technology, and create research and development tools to improve the timeline and predictability for scaling molecules from proof of concept to market by reducing time and costs. Grants typically consist of research and development milestone payments to be received upon the achievement of the milestone events defined in the agreements.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">The milestone payments are evaluated at inception to determine whether the milestone events are considered probable of achievement and estimates are made of the amount of the milestone payments to include in the transaction price using the most likely amount method which is the single amount in a range of possible amounts. If it is probable that a significant revenue reversal will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> occur, the estimated milestone payment amount is included in the transaction price. Each reporting period, the Company re-evaluates the probability of achievement of the milestone events and any related constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative basis, which would affect grant revenues in the period of adjustment. Revenue is recognized over time using a time-based measure of progress towards the satisfaction of the performance obligations. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> </div> <!-- Field: Page; Sequence: 22; Value: 1 --> <!-- Field: /Page --> <div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Cost of Products Sold</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 22.5pt">Cost of products sold includes the production costs of renewable products, which include the cost of raw materials, in-house manufacturing labor and overhead, amounts paid to contract manufacturers, including amortization of tolling fees, and period costs including inventory write-downs resulting from applying lower of cost or net realizable value inventory adjustments. Cost of products sold also includes certain costs related to the scale-up of production. Shipping and handling costs charged to customers are recorded as revenues. Outbound shipping costs incurred are included in cost of products sold. Such charges were <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> material for any of the periods presented.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0">The Company recognizes deferred cost of products sold as an asset on the balance sheet when a cost is incurred in connection with a revenue performance obligation that will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> be fulfilled until a future period.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 12pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Research and Development</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Research and development costs are expensed as incurred and include costs associated with research performed pursuant to collaborative agreements and government grants, including internal research. Research and development costs consist of direct and indirect internal costs related to specific projects, as well as fees paid to others that conduct certain research activities on the Company&#x2019;s behalf.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Debt Extinguishment</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 12pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The Company accounts for the income or loss from extinguishment of debt in accordance with ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">470,</div> <div style="display: inline; font-style: italic;">Debt,</div> which indicates that for all extinguishment of debt, the difference between the reacquisition consideration and the net carrying amount of the debt being extinguished should be recognized as gain or loss when the debt is extinguished. Losses from debt extinguishment are shown in the consolidated statements of operations under "Other income (expense)" as "Loss upon extinguishment of debt".</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 12pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Stock-based Compensation</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The Company accounts for stock-based employee compensation plans under the fair value recognition and measurement provisions of U.S. GAAP. Those provisions require all stock-based payments to employees, including grants of stock options and restricted stock units (RSUs), to be measured using the grant-date fair value of each award. The Company recognizes stock-based compensation expense net of expected forfeitures over each award's requisite service period, which is generally the vesting term. Expected forfeiture rates are estimated based on the Company's historical experience. Stock-based compensation plans are described more fully in Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,</div> "Stock-based Compensation".</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Income Taxes</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The Company is subject to income taxes in the United States and foreign jurisdictions and uses estimates to determine its provisions for income taxes. The Company uses the asset and liability method of accounting for income taxes, whereby deferred tax asset or liability account balances are calculated at the balance sheet date using current tax laws and rates in effect for the year in which the differences are expected to affect taxable income.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> </div> <!-- Field: Page; Sequence: 23; Value: 1 --> <!-- Field: /Page --> <div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Recognition of deferred tax assets is appropriate when realization of such assets is more likely than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not.</div> The Company recognizes a valuation allowance against its net deferred tax assets unless it is more likely than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> that such deferred tax assets will be realized. This assessment requires judgement as to the likelihood and amounts of future taxable income by tax jurisdiction.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The Company applies the provisions of Financial Accounting Standards Board (FASB) guidance on accounting for uncertainty in income taxes. The Company assesses all material positions taken in any income tax return, including all significant uncertain positions, in all tax years that are still subject to assessment or challenge by relevant taxing authorities. Assessing an uncertain tax position begins with the initial determination of the position&#x2019;s sustainability, and the tax benefit to be recognized is measured at the largest amount of benefit that is greater than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50</div>&nbsp;percent likely of being realized upon ultimate settlement. As of each balance sheet date, unresolved uncertain tax positions must be reassessed, and the Company will determine whether (i)&nbsp;the factors underlying the sustainability assertion have changed and (ii)&nbsp;the amount of the recognized tax benefit is still appropriate. The recognition and measurement of tax benefits requires significant judgement, and such judgements <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>change as new information becomes available.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Foreign Currency Translation</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The assets and liabilities of foreign subsidiaries, where the local currency is the functional currency, are translated from their respective functional currencies into U.S. dollars at the rates in effect at each balance sheet date, and revenue and expense amounts are translated at average rates during each period, with resulting foreign currency translation adjustments recorded in other comprehensive loss, net of tax, in the consolidated statements of stockholders&#x2019; deficit. As of&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>&nbsp;and&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> cumulative translation adjustment, net of tax, were <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$43.3</div> million&nbsp;and&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$42.2</div> million, respectively.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">Where the U.S. dollar is the functional currency, remeasurement adjustments are recorded in other income (expense), net in the accompanying consolidated statements of operations. Net losses resulting from foreign exchange transactions were&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.6</div> million and&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.4</div> million&nbsp;for the years ended&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> respectively and are recorded in other income (expense), net in the consolidated statements of operations.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><div style="display: inline; font-weight: bold;">New Accounting Standards or Updates Recently Adopted</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><div style="display: inline; font-weight: bold;">&nbsp;</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">During the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> the Company adopted the following Accounting Standards Updates (ASUs):</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Revenue Recognition</div></div> The Company adopted ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606,</div> <div style="display: inline; font-style: italic;">Revenue from Contracts with Customers</div>, with a date of initial application of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018. </div>As a result, the Company has changed its accounting policy for revenue recognition as detailed above in &#x201c;Significant Accounting Policies&#x201d;. The Company applied ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606</div> using the modified retrospective approach by recognizing the cumulative effect of initially applying ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606</div> to all contracts <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> completed as of the date of adoption as an adjustment to the opening balance of accumulated deficit at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018. </div>Therefore, the comparative information has <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> been adjusted and continues to be reported under the legacy revenue recognition guidance of ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">605,</div> "Revenue Recognition".</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The Company applied ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606</div> using a practical expedient for contracts that were modified before the application date, which allowed the Company to determine an aggregate effect of all modifications that occurred before <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018, </div>when determining the satisfied and unsatisfied performance obligations, the transaction price, and allocating that transaction price to the performance obligations instead of retrospectively restating the contracts for such contract modifications.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The cumulative effect of initially applying ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606</div> resulted in an increase to accumulated deficit at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018 </div>of approximately <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.8</div> million. The most significant change in accounting policy is the Company is now required to estimate royalty revenues from licenses of the Company&#x2019;s intellectual property and recognize estimated royalty revenues at a point in time when the Company sells its renewable products to its customers (if the sales-based royalty exception does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> apply) or when the licensee sells its products to its customer (if the sales-based royalty exception does apply).</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> </div> <!-- Field: Page; Sequence: 24; Value: 1 --> <!-- Field: /Page --> <div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The following table presents the amounts by which revenue is affected in the current reporting period by the application of ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606</div> as compared with the legacy guidance that was in effect before the accounting change.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div> <table style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;" cellspacing="0" cellpadding="0" align="center"> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td style="font-weight: bold; padding-bottom: 1pt">&nbsp;</td> <td colspan="11" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Year Ended December 31, 2018</td> </tr> <tr style="vertical-align: bottom"> <td style="font-weight: bold; border-bottom: Black 1pt solid">(In thousands)</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">As Reported</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Adjustments</td> <td style="font-weight: bold; padding-bottom: 1pt; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Amounts Without the Adoption of ASC 606</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 52%; text-align: left">Renewable products</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">33,598</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 2%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 12%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">33,598</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Licenses and royalties</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,658</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,094</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,752</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt">Grants and collaborations</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">22,348</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(5,786</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">)</td> <td style="padding-bottom: 1pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,562</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt">Total revenue from all customers</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">63,604</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(692</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">)</td> <td style="padding-bottom: 2.5pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">62,912</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Financial Instruments</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 2016, </div>the Financial Accounting Standards Board (FASB) issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">01,</div>&nbsp;<div style="display: inline; font-style: italic;">Financial Instruments-Overall (Subtopic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">825</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div>): Recognition and Measurement of Financial Assets and Financial Liabilities</div>, which changes the accounting for equity investments, financial liabilities under the fair value option, and the presentation and disclosure requirements for financial instruments. The Company adopted ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">01</div> on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018. </div>Adoption&nbsp;of this&nbsp;ASU did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div>&nbsp;impact the Company's consolidated financial position, results of operations or cash flows.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Classification of Cash Flow Elements</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2016, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15,</div>&nbsp;<div style="display: inline; font-style: italic;">Statement of Cash Flows (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">230</div>):&nbsp;Classification of Certain Cash Receipts and Cash Payments,</div>&nbsp;which affects the classification of certain cash receipts and cash payments on the statement of cash flows. ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15</div> results in a change in cash flow classification of debt prepayment or extinguishment costs. ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15</div> became effective <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018 </div>on a retrospective basis. Adoption&nbsp;of this&nbsp;ASU did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div>&nbsp;impact the Company's consolidated financial position, results of operations or cash flows.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Income Taxes Related to Intra-entity Asset Transfers</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 2016, </div>FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> <div style="display: inline; font-style: italic;">Intra-Entity Transfers of Assets Other Than Inventory</div> on simplifying the accounting for income taxes related to intra-entity asset transfers. The new guidance allows an entity to recognize the tax expense from the sale of an asset in the seller&#x2019;s tax jurisdiction when the transfers occurs, even though the pre-tax effects of that transaction are eliminated in consolidation. ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16</div> became effective <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018, </div>which the Company adopted on a modified retrospective basis.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Restricted Cash in Statement of Cash Flows</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2016, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,</div>&nbsp;<div style="display: inline; font-style: italic;">Statement of Cash Flows (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">230</div>): Restricted Cash,</div>&nbsp;which requires that a statement of cash flows explain the change during the period in the total of cash, cash equivalents, and amounts generally described as restricted cash or restricted cash equivalents. Therefore, amounts generally described as restricted cash and restricted cash equivalents should be included with cash and cash equivalents when reconciling the beginning-of-period and end-of-period total amounts shown on the statement of cash flows. The accounting standard update became effective <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018 </div>using a retrospective transition method for each period presented. Upon adoption, ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18</div> resulted in a change in the presentation of restricted cash in the statement of cash flows for current and prior periods presented.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;">&nbsp;</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Derecognition of Nonfinancial Assets</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 2017, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">05,</div>&nbsp;<div style="display: inline; font-style: italic;">Other Income&#x2014;Gains and Losses from the Derecognition of Nonfinancial Assets (Subtopic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">610</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">20</div>): Clarifying the Scope of Asset Derecognition Guidance and Accounting for Partial Sales of Nonfinancial Assets</div>, which requires entities to apply certain recognition and measurement principles in ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606</div> when they derecognize nonfinancial assets, and in substance, nonfinancial assets, and the counterparty is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> a customer. The guidance applies to: (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div>) contracts to transfer to a noncustomer a nonfinancial asset or group of nonfinancial assets, or an ownership interest in a consolidated subsidiary that does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> meet the definition of a business and is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div>-for-profit activity; and (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div>) contributions of nonfinancial assets that are <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> a business to a joint venture or other noncontrolled investee. The accounting standard update became effective <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018 </div>on a modified retrospective basis. Adoption&nbsp;of this&nbsp;ASU did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div>&nbsp;impact the Company's consolidated financial position, results of operations or cash flows.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> </div> <!-- Field: Page; Sequence: 25; Value: 1 --> <!-- Field: /Page --> <div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Income Taxes </div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 2018, </div>FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">05,</div> <div style="display: inline; font-style: italic;">Amendments to SEC Paragraphs Pursuant to SEC Staff Accounting Bulletin <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">No.</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">118</div></div> to address the application of GAAP in situations when a registrant does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> have the necessary information available, prepared or analyzed (including computations) in reasonable detail to complete the accounting for certain income tax effects of the Tax Act. As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018, </div>the Company's analysis for the Transition Tax has been filed with its <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017 </div>tax return and the Company considered its accounting for this area of the Tax Act to be complete as of such date and did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> make any measurement-period adjustments related to it. In addition, the Company considered its accounting for changes in the U.S. federal rate and deferred tax impact for the rate change to be complete. The Company also accounted for the tax impact related to other areas of the Tax Act and believe its analysis to be completed consistent with the guidance in ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">05.</div> The Company recognizes that the IRS is continuing to publish and finalize ongoing guidance with respect to the Act which <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>modify accounting interpretation for the Tax Act, the Company would look to account for these impacts in the period of such change is enacted.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Non-employee Stock-based Compensation</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 2018, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">07,</div> <div style="display: inline; font-style: italic;">Improvements to Nonemployee Share-Based Payment Accounting,</div> which more closely aligns the accounting for employee and nonemployee stock-based compensation. Under the new standard, companies are <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> longer required to value non-employee awards differently from employee awards. The Company adopted this accounting standard update on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2018 </div>using a modified retrospective approach. Adoption&nbsp;of this&nbsp;ASU did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div>&nbsp;impact the Company's consolidated financial position, results of operations or cash flows.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><div style="display: inline; font-weight: bold;">Recent Accounting Standards or Updates <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">Not</div> Yet Effective</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Leases</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 2016, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">02,</div>&nbsp;<div style="display: inline; font-style: italic;">Leases (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">842</div>),</div>&nbsp;as subsequently updated, with fundamental changes as to how entities account for leases. Lessees will need to recognize a right-of-use asset and a lease liability for virtually all of their leases (other than leases that meet the definition of a short-term lease). The liability will be equal to the present value of lease payments. The asset will be based on the liability, subject to adjustment, such as for initial direct costs. Additional disclosures for leases will also be required.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The Company is adopting the new standard effective <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2019 </div>using a modified retrospective method, and will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> restate comparative periods. The modified retrospective transition approach requires lessees and lessors to recognize and measure existing leases at the date of initial application. The new standard provides a number of optional practical expedients in transition. The Company expects to elect the &#x201c;package of practical expedients&#x201d;, which permits it <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> to reassess under the new standard prior conclusions about lease identification, lease classification and initial direct costs.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> </div> <!-- Field: Page; Sequence: 26; Value: 1 --> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The adoption of this standard on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2019 </div>is expected to have the effect of increasing assets and liabilities on the consolidated balance sheet by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$25.7</div> million, but is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> expected to have a material impact on the consolidated statements of operations or cash flows.&nbsp;The most significant impact relates to (i) the recognition of new Right of Use (ROU) assets and lease liabilities on the balance sheet for operating leases; and (ii) providing significant new disclosures about leasing activities. Upon adoption, the Company will recognize operating lease liabilities of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$33.6</div> million, based on the present value of the remaining minimum rental payments under current leasing standards for existing operating leases.&nbsp;The Company will also recognize ROU assets of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$29.7</div> million, which represents the operating lease liability adjusted for accrued rent.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Financial Instruments with "Down Round" Features</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2017, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,</div>&nbsp;<div style="display: inline; font-style: italic;">Earnings Per Share (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">260</div>); Distinguishing Liabilities from Equity (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">480</div>); Derivatives and Hedging (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">815</div>): Accounting for Certain Financial Instruments with Down Round Features</div>. The amendments of this ASU update the classification analysis of certain equity-linked financial instruments, or embedded features, with down round features, as well as clarify existing disclosure requirements for equity-classified instruments. When determining whether certain financial instruments should be classified as liabilities or equity instruments, a down round feature <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> longer precludes equity classification when assessing whether the instrument is indexed to an entity&#x2019;s own stock. The accounting standard update will be effective beginning in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> quarter of fiscal year <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> using a modified retrospective approach. The Company completed its assessment of the new standard and determined the impact to the consolidated balance sheet would be material. The Company anticipates recording a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$41.0</div> million reduction to derivative liabilities and a corresponding <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$41.0</div> million increase to equity on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2019.</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Fair Value Measurement</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2018, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,</div> <div style="display: inline; font-style: italic;">Fair Value Measurement (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">820</div>): Disclosure Framework&#x2014;Changes to the Disclosure Requirements for Fair Value Measurement</div>, which amends ASC <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">820,</div> <div style="display: inline; font-style: italic;">Fair Value Measurement</div>. ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div> modifies the disclosure requirements for fair value measurements by removing, modifying or adding certain disclosures. The accounting standard update will be effective beginning in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> quarter of fiscal year <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2020,</div> with removed and modified disclosures to be adopted on a retrospective basis, and new disclosures to be adopted on a prospective basis. The Company is in the initial stages of evaluating the impact of the new standard on its consolidated financial statements.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Collaborative Revenue Arrangements</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,</div> <div style="display: inline; font-style: italic;">Clarifying the Interaction between Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">808</div> and Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606</div></div>, that clarifies the interaction between the guidance for certain collaborative arrangements and Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">606,</div> the new revenue recognition standard. A collaborative arrangement is a contractual arrangement under which <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> or more parties actively participate in a joint operating activity and are exposed to significant risks and rewards that depend on the activity&#x2019;s commercial success. The ASU provides guidance on how to assess whether certain transactions between collaborative arrangement participants should be accounted for within the revenue recognition standard. The accounting standard update will be effective beginning in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> quarter of fiscal year <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2020</div> retroactively. The Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> believe that the impact of the new standard on its consolidated financial statements will be material.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-style: italic;"><div style="display: inline; text-decoration: underline;">Credit Losses</div></div> In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 2016, </div>the FASB issued ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,</div> <div style="display: inline; font-style: italic;">Financial Instruments&#x2014;Credit Losses (Topic <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">326</div>), Measurement of Credit Losses on Financial Instruments</div>. ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div> requires entities to measure all expected credit losses for most financial assets held at the reporting date based on an expected loss model which includes historical experience, current conditions, and reasonable and supportable forecasts. Entities will now use forward-looking information to better form their credit loss estimates. ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div> also requires enhanced disclosures to help financial statement users better understand significant estimates and judgments used in estimating credit losses, as well as the credit quality and underwriting standards of an entity's portfolio. ASU <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2016</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13</div> will become effective for the Company beginning in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> quarter of fiscal year <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2020.</div> The Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> believe that the impact of the new standard on its consolidated financial statements will be material.</div></div> 47058 246230 1643991000000 292398 1643991 205168 25000 2826711 12958 1068379 1643991 6732369 2832440 2043781 913529 323382 1243781 2826711 205168 156104 407858 246230 47058 70807 134 70807 777000 777000 6100000 7300000 25000000 562000 562000 16675000 16675000 6197000 6197000 1415000 1415000 -385000 -385000 -260000 -260000 1000 1000 288000 288000 -217756000 -218025000 -200644000 -17381000 2000 990895000 -40904000 -1134438000 937000 -183508000 5000000 5000 1114546000 -42156000 -1290420000 937000 -217088000 5000000 8000 1346996000 -43343000 -1521417000 937000 -216819000 5000000 -199707000 -17381000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font-size: 10pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7.</div> Stockholders&#x2019; Deficit</div></div> <div style=" font-size: 10pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;">&nbsp;</div></div> <div style=" font-size: 10pt; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Warrants</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">The Company issues warrants in certain debt and equity transactions in order to facilitate raising equity capital or reduce borrowing costs. In connection with various debt and equity transactions (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> "Debt" and below), the Company has issued warrants exercisable for shares of common stock. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>cash and dilution warrants, and the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2015 </div>related party debt exchange warrants are accounted for as derivative liabilities. See the Temasek Funding Warrant and Series A and B sections below for more information. The following table summarizes warrant activity for the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018:</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; border-bottom: Black 1pt solid">Transaction</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Number Outstanding as of <br /> December 31, 2017</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Additional <br /> Warrants Issued</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Exercises</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Number Outstanding as of <br /> December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 52%">August 2018 warrant exercise agreements</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,097,164</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 9%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,097,164</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">May 2017 cash and dilution warrants</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18,042,568</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(11,749,770</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,292,798</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">August 2017 cash and dilution warrants</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,543,234</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,713,565</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(7,288,683</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,968,116</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>April 2018 warrant exercise agreements</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,616,174</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,616,174</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">July 2015 related party debt exchange</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,082,010</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">471,204</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(1,889,986</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">663,228</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">February 2016 related party private placement</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">171,429</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">171,429</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>July 2015 private placement</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">81,197</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">81,197</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Other</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,406</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,406</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29,921,844</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">17,898,107</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(20,928,439</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">)</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">26,891,512</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: center; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">For information regarding warrants issued subsequent to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018, </div>see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> &#x201c;Subsequent Events&#x201d;.</div> <div style=" font-size: 10pt; text-align: center; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: center; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Shares Issuable under Convertible Notes</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In connection with various debt transactions (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> "Debt"), the Company issued certain convertible notes that are convertible into shares of common stock as follows as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> at any time at the election of each debtholder:</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; border-bottom: Black 1pt solid">Debt Instrument</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Number of Shares into Which <br /> Debt Instrument Is Convertible <br /> as of December 31, 2018</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 84%; text-align: left">6% convertible notes due 2021</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 13%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,493,672</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2015 Rule 144A convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,338,560</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">August 2013 financing convertible notes</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,003,554</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">2014 Rule 144A convertible notes</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">867,376</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,703,162</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> Warrant Exercises and New Warrant Issuances</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 2018 </div>Warrant Transactions</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 12, 2018, </div>in accordance with the terms of the Warrant Exercise Agreement, certain holders of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Warrants (see below under <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> &#x201c;May 2017 </div>Offerings&#x201d;) exercised their <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Cash Warrants in full to purchase an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,616,174</div> shares of common stock for net proceeds to the Company of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$14.5</div> million and surrendered their <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Dilution Warrants for cancellation. Upon exercise of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Cash Warrants and surrender of such <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Dilution Warrants, certain derivative liabilities representing certain anti-dilution rights contained in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Warrants were effectively settled. Under the terms of the Warrant Exercise Agreements, the exercise of such <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Cash Warrants and surrender of such <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Dilution Warrants was required on the date of the Warrant Exercise Agreement in order for the Company to issue new warrants to these same holders to purchase an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,616,174</div> shares of common stock, exercisable at a price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$7.00</div> per share. The new warrants were fully exercisable upon issuance, with an expiration date of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 12, 2019. </div>The new warrants do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> provide the holders with anti-dilution protection and only permit &#x201c;cashless&#x201d; exercise after the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">six</div>-month anniversary of issuance, and only to the extent that there is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> an effective registration statement covering the resale of the shares of common stock underlying the new warrants; on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 26, 2018, </div>the Company filed such a registration statement, which was declared effective on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 11, 2018. </div>The new warrants were evaluated for liability classification, and while meeting the definition of a derivative, the freestanding instruments met the indexation and equity classification criteria to be accounted for as equity.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2018 </div>Warrant Transactions</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2018 </div>in accordance with the terms of the Warrant Exercise Agreements, Foris Ventures, LLC (Foris) and entities affiliated with Vivo Capital LLC (Vivo), related parties and holders of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Warrants and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Warrants (see below under <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> &#x201c;August 2017 </div>Vivo Offering&#x201d;), respectively, exercised their Cash Warrants and, in the case of Foris, Dilution Warrants in full and in accordance with the terms of the Warrant Exercise Agreements, to purchase an aggregate of approximately <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12.6</div> million shares of common stock for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$43.0</div> million in proceeds to the Company, and Vivo subsequently surrendered their Dilution Warrants for cancellation. In connection with the entry by the Company and Vivo into Warrant Exercise Agreement, the Company and Vivo amended the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Cash Warrants to&nbsp;(i) reduce the exercise price of such warrants from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.39</div> per share to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.40</div> per share and (ii) remove the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Offering Beneficial Ownership Limitation from such warrants. Upon exercise and surrender of such Cash Warrants and Dilution Warrants, certain derivative liabilities representing certain anti-dilution rights contained in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Warrants and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Warrants were effectively settled. Under the terms of the Warrants Exercise Agreement, the exercise of the Cash Warrants and Dilution Warrants and subsequent surrender of the Vivo Dilution Warrants was required on the date of the Warrants Exercise Agreement in order for the Company to issue a series of new warrants to these same holders to purchase an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12.1</div> million shares of common stock, exercisable at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$7.52</div> per share. The new warrants are exercisable any time after the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">six</div>-month anniversary of issuance and for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">15</div> months thereafter, with an expiration date in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2020. </div>The new warrants do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> provide the holders with anti-dilution protection and only permit &#x201c;cashless&#x201d; exercise after the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">twelve</div>-month anniversary of issuance, and only to the extent that there is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> an effective registration statement covering the resale of the shares of common stock underlying the new warrants. The new warrants were evaluated for liability classification, and while meeting the definition of a derivative, the freestanding instruments met the indexation and equity classification criteria to be accounted for as equity.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Temasek Funding Warrant &#x2013; Related Party</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">Following amendments to certain common stock purchase warrants in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2018 (</div>see below under <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> &#x201c;May 2017 </div>Offerings&#x201d; and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> &#x201c;August 2017 </div>Vivo Offering&#x201d;), and a corresponding adjustment to the conversion price of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2013 </div>financing convertible notes from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.2977</div> per share to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.40</div> per share (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> &#x201c;Debt&#x201d;), the Temasek Funding Warrant became exercisable for an additional <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">471,204</div> shares of common stock in accordance with its terms. On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 19, 2018, </div>Temasek exercised the Temasek Funding Warrant with respect to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,889,986</div> shares of common stock underlying the Temasek Funding Warrant by means of a cashless exercise, resulting in the issuance of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,852,585</div> shares of common stock to Temasek. As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018, </div>there were <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">471,204</div> shares underlying the Temasek Funding Warrant. As a result of this exercise, the derivative liability related to the Temasek Funding Warrant decreased by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$14.0</div> million.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;"></div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018 </div>DSM Securities Purchase Agreement &#x2013; Related Party</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 20, 2018, </div>the Company issued <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,643,991</div> shares of common stock (the DSM Shares) at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.68</div> per share to DSM in a private placement pursuant to a securities purchase agreement, dated <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 19, 2018, </div>between the Company and DSM (the DSM SPA), in consideration of certain agreements of DSM set forth in the Supply Agreement Amendment described in Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> "Revenue Recognition". The Company also agreed to pay DSM the difference between the DSM SPA purchase price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.41</div> and the closing share price of the Company's common stock on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 28, 2019, </div>multiplied by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,643,991.</div> At inception, the Company recorded a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.2</div> million derivative liability for the difference between <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.41</div> and the Company&#x2019;s closing stock price on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 20, 2018. </div>At <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018 </div>fair value based on the Company&#x2019;s closing stock price was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.8</div> million, resulting in a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.6</div> million loss on change in fair value for the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018. </div>At <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 28, 2019, </div>the Company's stock price was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.10,</div> and the Company owed DSM <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.8</div> million in connection with this agreement. Pursuant to the DSM SPA, the Company agreed to file a registration statement providing for the resale by DSM of the DSM Shares and to use commercially reasonable efforts to (i) cause such registration statement to become effective within <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">181</div> days following the date of the DSM SPA and (ii) keep such registration statement effective until DSM does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> own any DSM Shares or the DSM Shares are eligible for resale under Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144</div> without regard to volume limitations. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,</div> "Related Party Transactions" for additional information about the accounting for this transaction and other <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018 </div>transactions with DSM. In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 2019, </div>in connection with the assignment by the Company of its rights under the Value Sharing Agreement (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> "Revenue Recognition"), the Company satisfied its obligation under the Supply Agreement Amendment relating to the difference between <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.41</div> and the price of the Company&#x2019;s common stock on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 28, 2019. </div>See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> &#x201c;Subsequent Events&#x201d; for additional information.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;"></div></div></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; color: #231F20"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">At</div></div></div><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;"> Market Issuance Sales <div style="display: inline; color: #231F20">Agreement</div></div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 8, 2016, </div>the Company entered into an At Market Issuance Sales Agreement (ATM Sales Agreement) with FBR Capital Markets &amp; Co. and MLV &amp; Co. LLC (Agents) under which the Company would be able to issue and sell shares of its common stock having an aggregate offering price of up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$50.0</div> million (ATM Shares) from time to time through the Agents, acting as its sales agents, under the Company's Registration Statement on Form S-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div> (File <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">No.</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">333</div>-<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">203216</div>), effective <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 15, 2015. </div>Sales of the ATM Shares through the Agents would be made by any method that is deemed an "at the market offering" as defined in Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">415</div> under the Securities Act of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1933,</div> as amended, including by means of ordinary brokers' transactions at market prices, in block transactions, or as otherwise agreed by the Company and the Agents. The Company agreed to pay the applicable Agent a commission rate of up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3.0%</div> of the gross proceeds from the sale of any ATM Shares sold through such Agent under the ATM Sales Agreement. The ATM Sales Agreement included <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> commitment by other parties to purchase ATM Shares the Company offers for sale.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 0">During the&nbsp;year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> the Company issued and sold&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">205,168</div> shares of common stock under the ATM Sales Agreement, at an average price of&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.90</div> per share, resulting in total net proceeds to the Company of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.4</div> million. <div style="display: inline; color: #231F20">During</div> the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> the Company did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> sell any shares of common stock under the ATM Sales Agreement. The ATM Sales Agreement expired on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 15, 2018, </div>and as a result, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">zero</div> remained available for issuance under the ATM Sales Agreement as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018.</div></div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" color: #231F20; font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Offerings</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 32pt; margin: 0pt 7pt">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"><div style="display: inline; color: #231F20">In</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017, </div>the Company issued and sold an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">22,140</div> shares of Series A <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">17.38%</div> Convertible Preferred Stock (Series A Preferred Stock), <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">70,904</div> shares of Series B <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">17.38%</div> Convertible Preferred Stock (Series B Preferred Stock), and warrants to purchase an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,384,190</div> shares of common stock at an initial exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$7.80</div> per share, warrants to purchase an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,384,190</div> shares of common stock at an initial exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$9.30</div> per share, and warrants to purchase a number of shares of common stock sufficient to provide full-ratchet anti-dilution protection with respect to the effective price paid for the common stock underlying the Series A Preferred Stock and Series B Preferred Stock (collectively, the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Warrants) in separate offerings, certain of which were registered under the Securities Act or others of which were private placements (collectively, the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Offerings).</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 32pt; margin: 0pt 7pt">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"><div style="display: inline; color: #231F20">The</div> net proceeds to the Company from the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Offerings were <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$50.7</div> million after payment of offering expenses and placement agent fees. The Series A Preferred Stock and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Warrants relating thereto were sold to the purchasers thereof in exchange for aggregate cash consideration of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$22.1</div> million, and the Series B Preferred Stock and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Warrants relating thereto were sold to the purchasers thereof in exchange for (i) aggregate cash consideration of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$30.7</div> million and (ii) the cancellation of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$40.2</div> million of outstanding indebtedness (including accrued interest thereon) owed by the Company to certain purchasers, of which <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$33.1</div> million was from related parties, as further described below.</div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"></div></div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Series A and B Preferred Stock</div></div></div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Series A Prefer<div style="display: inline; color: #231F20">red Stock</div></div></div> <div style=" font-size: 10pt; text-indent: 0.5in; margin: 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">Each share of Series A Preferred Stock has a stated value of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1,000</div> and is convertible at any time, at the option of the holder, into common stock at a conversion price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$17.25</div> per share (Preferred Stock Conversion Rate). The Preferred Stock Conversion Rate is subject to adjustment in the event of any dividends or distributions of common stock, or any stock split, reverse stock split, recapitalization, reorganization or similar transaction. If <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> previously converted at the option of the holder, each share of Series A Preferred Stock automatically converted on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 9, 2017, </div>the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">90th</div> day following the date that the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2017 </div>Stockholder Approval (as defined below) was obtained and effected, subject to the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Offerings Beneficial Ownership Limitation (as defined below).</div> <div style=" font-size: 10pt; margin: 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">Dividends, at a rate per year equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">17.38%</div> of the stated value of the Series A Preferred Stock, will be payable semiannually from the issuance of the Series A Preferred Stock until the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">tenth</div> anniversary of the date of issuance, on each <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 15 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 15, </div>beginning <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 15, 2017, </div>on a cumulative basis, at the Company's option, in cash, out of any funds legally available for the payment of dividends, or, subject to the satisfaction of certain conditions, in Common Stock at the Preferred Stock Conversion Rate, or a combination thereof. Upon the conversion of the Series A Preferred Stock prior to the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">tenth</div> anniversary of the date of issuance, the holders of the Series Preferred A Stock shall be entitled to a payment equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1,738</div> <div style="display: inline; font-size: 10pt; color: #231F20">per <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1,000</div> of stated value of the Series A Preferred Stock, less the amount of all prior semiannual dividends paid on such converted Series A Preferred Stock prior to the relevant conversion date (Make-Whole Payment), at the Company's option, in cash, out of any funds legally available for the payment of dividends, or, subject to the satisfaction of certain conditions, in common stock at the Preferred Stock Conversion Rate, or a combination thereof. If the Company elects to pay any dividend in the form of cash, it shall provide each holder with notice of such election <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> later than the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> day of the month of prior to the applicable dividend payment date.</div></div> <div style=" font-size: 10pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; margin: 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">Unless and until converted into common stock in accordance with its terms, the Series A Preferred Stock has <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> voting rights, other than as required by law or with respect to matters specifically affecting the Series A Preferred Stock.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">Upon any liquidation, dissolution or winding-up of the Company, the holders of the Series A Preferred Stock shall be entitled to receive out of the assets of the Company the same amount that a holder of Common Stock would receive if the Series A Preferred Stock were fully converted to common stock immediately prior to such liquidation, dissolution or winding-up (without regard to whether such Series A Preferred Stock is convertible at such time), which amount shall be paid <div style="display: inline; font-style: italic;">pari passu</div> with all holders of Common Stock.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">The conversion of the Series A Preferred Stock is subject to a beneficial ownership limitation of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.99%</div> (or such other percentage <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> to exceed <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9.99%,</div> provided that any increase will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> be effective until <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">61</div> days after notice thereof by the holder) of the number of shares of common stock outstanding immediately after giving effect to the issuance of shares of common stock issuable upon conversion of such Series A Preferred Stock (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Offerings Beneficial Ownership Limitation). In addition, prior to obtaining the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2017 </div>Stockholder Approval (as defined below), the aggregate number of shares issued with respect to the Series A Preferred Stock (and any other transaction aggregated for such purpose) could <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> exceed <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,792,778</div> shares of common stock (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Exchange Cap).</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"></div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">The Series A Preferred Stock is classified as permanent equity, as the Company controls all actions or events required to settle the optional and mandatory conversion feature in shares. The Make-Whole Payment was determined to be an embedded derivative requiring bifurcation and separate recognition as a derivative liability recognized at its fair value as of the issuance date with subsequent changes in fair value recorded in earnings until the earlier of (i) <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 7, 2017 </div>when the Make-Whole shares became fixed and certain, (ii) the Series A Preferred Stock is converted into common stock, (iii) the Make-Whole Payment is voluntarily converted, or (iv) the Make-Whole Payment is paid through declared dividends or cash. A derivative liability was recognized at fair value on the date of issuance for the Make-Whole Payment in the amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$11.0</div> million. The value of the remaining Make-Whole derivative liability at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 7, 2017 </div>was extinguished to equity. All Make-Whole Payment conversions into common stock before and after <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 7, 2017, </div>were accounted for as a deemed dividend in the period converted. A derivative liability was also recognized at fair value on the date of issuance for the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Warrants issued to the Series A holders (discussed more fully below) in the amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$10.6</div> million. The Series A Preferred Stock also contained a beneficial conversion feature which was recognized up to the amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.6</div> million of proceeds allocated to the preferred stock. Net proceeds allocated to the Series A Preferred Stock were <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.6</div> million.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017, </div>all <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">22,140</div> shares of Series A Preferred Stock had been converted into common stock (with the Make-Whole Payment in each case being made in the form of common stock) and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">zero</div> shares of Series A Preferred Stock were outstanding. Upon conversion of the Series A Preferred Shares, the Company recognized a deemed dividend for the unamortized discount related to the allocation of proceeds to the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Warrants derivatives totaling <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$21.6</div> million, and deemed dividends upon settlement of the Series A Make-Whole Payment totaling <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$10.5</div> million, all as a reduction to Additional Paid-in Capital and an increase to net loss attributable to Amyris, Inc. common stockholders.</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"></div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Series B Preferred Stock</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 32pt; margin: 0pt 7pt">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">The Series B Preferred Stock has substantially identical terms to the Series A Preferred Stock, except that (i) the conversion of the Series B Preferred Stock was subject to the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2017 </div>Stockholder Approval and (ii) the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Offerings Beneficial Ownership Limitation does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> apply to DSM. The Series B Preferred Stock was classified as permanent equity at issuance due to the lack of a cash redemption feature and because the holder&#x2019;s only recourse to affect conversion was to require the Company to continually seek shareholder approval, thus effectively giving the Company control over the actions or events necessary to settle an optional or mandatory conversion feature in shares. As described in more detail below under <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> &#x201c;July 2017 </div>Stockholder Approval,&#x201d; in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2017 </div>the Company&#x2019;s stockholders approved removing a restriction preventing the Series B Preferred Stock issued in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Offerings from being convertible into common stock.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 32pt; margin: 0pt 7pt"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 7pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">The investors that purchased shares of the Series B Preferred Stock included related parties affiliated with members of the Board: Foris exchanged an aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$27.0</div> million of indebtedness, plus accrued interest thereon, for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">30,729</div> shares of Series B Preferred Stock and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Warrants to purchase <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,877,386</div> shares of Common Stock and Naxyris exchanged an aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.0</div> million of indebtedness, plus accrued interest thereon, for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,333</div> shares of Series B Preferred Stock and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Warrants to purchase <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">370,404</div> shares of common stock. The fair value of the Series B Preferred Stock, the embedded Make-Whole payment and the related warrants exceeded the carrying value of the related party debt and accrued interest exchanged by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.6</div> million which was recorded as a loss upon extinguishment of debt as the Company determined that the related parties were acting in their interests as debt holders.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">The investors that purchased shares of the Series B Preferred Stock also included non-related party holders of the Company's <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes. These investors exchanged all or a portion of their holding of such indebtedness, including accrued interest thereon, representing an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.4</div> million of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.7</div> million of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes, for Series B Preferred Stock and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Warrants in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Offerings. The fair value of the Series B Preferred Stock, the embedded Make-Whole payment and the related warrants exceeded the carrying value of the debt and accrued interest exchanged by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.9</div> million, which was recognized as a loss on extinguishment of debt in other income (expense).</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">Issuance costs of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.2</div> million were netted against the proceeds. Additional issuance costs of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.2</div> million were expensed as debt extinguishment costs for debt that was exchanged in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Offerings.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 32pt; margin: 0pt 7pt">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">Upon the closing of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Offerings, all such exchanged indebtedness was canceled and the agreements relating thereto, including any note purchase agreements or unsecured or secured promissory notes (including any security interest relating thereto), were terminated, except to the extent such investors or other investors retain a portion of such indebtedness.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 32pt; margin: 0pt 7pt"></div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">A derivative liability was recognized at fair value on the date of issuance for the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>DSM Series B Make-Whole Payment in the amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$12.4</div> million. A derivative liability was also recognized at fair value on the date of issuance for the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Warrants issued to DSM (discussed more fully below) in the amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$11.9</div> million. Upon conversion of the DSM Series B Preferred Shares, the Company recognized a deemed dividend for the unamortized discounts related to the allocation of proceeds to the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>DSM Make-Whole Payment and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Warrants derivatives totaling <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$24.4</div> million, and a deemed dividend upon settlement of all <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Series B Make-Whole Payments totaling <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$22.6</div> million, all as a reduction to Additional Paid in Capital and an increase to net loss attributable to Amyris, Inc. common stockholders. The Series B Preferred Stock issued to DSM in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Offerings also contained a contingent beneficial conversion feature that was recognized in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> months ending <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 30, 2017 </div>upon the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2017 </div>Stockholder Approval, which eliminated the contingency. As a result, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.6</div> million was recorded as a reduction to Additional Paid in Capital and was considered a deemed dividend, increasing net loss attributable to Amyris, Inc. common stockholders.</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 32pt; margin: 0pt 7pt"></div> <!-- Field: /Page --> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">89,528</div> shares of Series B Preferred Stock (including the Series B Preferred Stock issued in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Offering) have been converted into common stock (with the Make-Whole Payment in each case being made in the form of common stock) and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,376</div> shares of Series B Preferred Stock were outstanding. At <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,213</div> shares of Series B Preferred Stock were outstanding.</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div><div style="display: inline; color: #231F20">Warrants</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 32pt; margin: 0pt 7pt">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">The Company issued to each investor in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Offerings warrants to purchase a number of shares of common stock equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100%</div> of the shares of common stock into which such investor's shares of Series A Preferred Stock or Series B Preferred Stock were initially convertible (including shares of common stock issuable as payment of dividends or the Make-Whole Payment, assuming that all such dividends and the Make-Whole Payment are made in common stock), representing warrants to purchase <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">14,768,380</div> shares of common stock in the aggregate for all investors (collectively, the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Cash Warrants). The exercise price of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Cash Warrants is subject to standard adjustments as well as full-ratchet anti-dilution protection for any issuance by the Company of equity or equity-linked securities during the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div>-year period following the issuance of such warrants (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Dilution Period) at a per share price less than the then-current exercise price of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Cash Warrants, subject to certain exceptions. As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> the exercise prices of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Cash Warrants were <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.40</div> per share and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Cash Warrants had been exercised. As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> the exercise prices of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Cash Warrants were <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.40</div> per share and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,523,560</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Cash Warrants had been exercised (see <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> &#x201c;April 2018 </div>Warrant Transactions&#x201d; and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> &#x201c;August 2018 </div>Warrant Transactions&#x201d; above).</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 32pt; margin: 0pt 7pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 32pt; margin: 0pt 7pt">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">In addition, the Company issued to each investor a warrant, with an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.0015</div> per share as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> (collectively, the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Dilution Warrants), to purchase a number of shares of common stock sufficient to provide the investor with full-ratchet anti-dilution protection for any issuance by the Company of equity or equity-linked securities during the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Dilution Period at a per share price less than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.30,</div> the effective per share price paid by the investors for the shares of common stock issuable upon conversion of their Series A Preferred Stock or Series B Preferred Stock (including shares of common stock issuable as payment of dividends or the Make-Whole Payment, assuming that all such dividends and the Make-Whole Payment are made in common stock) subject to certain exceptions. As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Dilution Warrants were exercisable for an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,377,466</div> shares based on an effective per share price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.40</div> per share, of which <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,329,488</div> warrants had been exercised, resulting in a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$64.1</div> million reduction in derivative liability. See <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> &#x201c;April 2018 </div>Warrant Transactions&#x201d; and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> &#x201c;August 2018 </div>Warrant Transactions&#x201d; above regarding the cancellation of certain <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Dilution Warrants.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 32pt; margin: 0pt 7pt">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Warrants each have a term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">five</div> years from the date such warrants initially became exercisable upon the receipt and effectiveness of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2017 </div>Stockholder Approval. The exercise of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Warrants (other than the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Warrants held by DSM) is subject to the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Offerings Beneficial Ownership Limitation. In connection with the entry by the Company and Foris into a warrant exercise agreement in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2018 </div>and related transactions (see <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> &#x201c;August 2018 </div>Warrant Transactions&#x201d; above), the Company and Foris amended Foris&#x2019;s <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Cash Warrants and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Dilution Warrant to remove the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Offerings Beneficial Ownership Limitation from such warrants. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Cash Warrants are freestanding financial instruments that are accounted for as derivative liabilities and recognized at their fair value on the date of issuance of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$39.5</div> million. As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> the fair value of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Cash Warrants was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$24.1</div> million, as determined with the assistance of an independent <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">third</div>-party appraisal.</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">For the years ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> the Company recorded a loss of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$13.5</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$40.4</div> million, respectively, to reflect change in fair value of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Cash Warrants (including the anti-dilution protection feature). Subsequent changes to the fair value of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Cash Warrants will continue to be recorded in earnings until the warrants are exercised or expire in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2022.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"></div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;"></div></div></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-indent: 22pt; margin: 0pt 0"><div style="display: inline; color: #231F20"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2017 </div></div></div><div style="display: inline; font-style: italic;">Stockholder <div style="display: inline; color: #231F20">Approval</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">In connection with the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Offerings, the Company agreed to solicit from its stockholders (i) any approval required by the rules and regulations of the NASDAQ Stock Market, including without limitation for the issuance of common stock upon conversion of the Series A Preferred Stock in excess of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Exchange Cap, upon conversion of the Series B Preferred Stock and upon exercise of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Warrants (the NASDAQ Approval) and (ii) approval to effect the Reverse Stock Split (collectively, the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2017 </div>Stockholder Approval) at an annual or special meeting of stockholders to be held on or prior to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 10, 2017, </div>and to use commercially reasonable efforts to secure the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2017 </div>Stockholder Approval. The Reverse Stock Split was approved by the Company&#x2019;s stockholders in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>and the NASDAQ Approval was obtained on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 7, 2017.</div></div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;"></div></div></div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; color: #231F20"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Offering</div></div></div><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;"> &#x2013; <div style="display: inline; color: #231F20">Related Party</div></div></div></div> <div style=" font-size: 10pt; text-indent: 0.5in; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"><div style="display: inline; color: #231F20">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 7, 2017, </div>the Company issued and sold the following securities to </div>DSM <div style="display: inline; color: #231F20">in a private placement (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Offering):</div></div> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; min-width: 700px;"> <tr style="vertical-align: top"> <td style="width: 0.25in">&nbsp;</td> <td style="width: 0.25in">&#x2022;</td> <td><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,000</div> shares of Series B Preferred Stock (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Series B Preferred Stock) at a price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1,000</div> per share;</td> </tr> </table> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; min-width: 700px;"> <tr style="vertical-align: top"> <td style="width: 0.25in">&nbsp;</td> <td style="width: 0.25in">&#x2022;</td> <td style="text-align: justify">a warrant to purchase <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,968,116</div> shares of common stock at an initial exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.30</div> per share expiring in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">five</div> years (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Cash Warrant); and</td> </tr> </table> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; color: #231F20; min-width: 700px;"> <tr style="vertical-align: top"> <td style="width: 0.25in">&nbsp;</td> <td style="width: 0.25in">&#x2022;</td> <td>the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Dilution Warrant (as described below).</td> </tr> </table> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"><div style="display: inline; color: #231F20">Net proceeds to the Company were <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$25.9</div> million after payment of offering expenses </div>and the allocation of total fair value received to the elements in the arrangement.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">The exercise price of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Cash Warrant is subject to standard adjustments as well as full-ratchet anti-dilution protection for any issuance by the Company of equity or equity-linked securities during the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div>-year period following <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 7, 2017 (</div>DSM Dilution Period) at a per share price less than the then-current exercise price of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Cash Warrant, subject to certain exceptions. As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> the exercise price of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Cash Warrant was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.40</div> per share.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Dilution Warrant allows DSM to purchase a number of shares of common stock sufficient to provide DSM with full-ratchet anti-dilution protection for any issuance by the Company of equity or equity-linked securities during the DSM Dilution Period at a per share price less than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.30,</div> the effective per share price paid by DSM for the shares of common stock issuable upon conversion of its Series B Preferred Stock (including shares of common stock issuable as payment of dividends or the Make-Whole Payment (as defined below), assuming that all such dividends and the Make-Whole Payment are made in common stock), subject to certain exceptions and subject to a price floor of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.10</div> per share (Dilution Floor). The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Dilution Warrant expires <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">five</div> years from the date it is initially exercisable.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"></div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">In connection with the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Offering, the Company also agreed that, subject to certain exceptions, it would <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> (i) issue any shares of common stock or securities convertible into or exercisable or exchangeable for common stock prior to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 31, 2017, (</div>ii) effect any issuance of securities involving a variable rate transaction until <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 11, 2018 </div>or (iii) issue any shares of common stock or securities convertible into or exercisable or exchangeable for common stock at a price below the Dilution Floor without DSM's consent. On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 19, 2018, </div>the Company entered into an agreement to reduce the exercise price of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Cash Warrant from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.30</div> to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.40</div> to compensate DSM for failure to obtain its consent to reduce the exercise price of the Vivo Warrant discussed in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> &#x201c;August 2018 </div>Warrant Transactions&#x201d; section of this Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7</div> &#x201c;Stockholders&#x2019; Deficit&#x201d;. The Company determined the fair value of this agreement to be <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.8</div> million and recorded a legal settlement expense for the period ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018 </div>in that amount. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,</div> "Fair Value Measurement" for additional information. The accounting treatment for this transaction was evaluated in conjunction with the other <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018 </div>transactions discussed in Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,</div> &#x201c;Related Party Transactions&#x201d;. Also, upon execution of this agreement the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Dilution Warrant became exercisable for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,713,565</div> shares based on an effective per share price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.0001</div> per share, all of which were exercised in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2018.</div></div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">In connection with the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Offering, the Company and DSM also entered into an amendment to the stockholder agreement dated <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 11, 2017 (</div>DSM Stockholder Agreement) between the Company and DSM (Amended and Restated DSM Stockholder Agreement). Under the DSM Stockholder Agreement, DSM was granted the right to designate <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> director selected by DSM, subject to certain restrictions and a minimum beneficial ownership level of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.5%,</div> to the Board. Furthermore, DSM has the right to purchase additional shares of capital stock of the Company in connection with a sale of equity or equity-linked securities by the Company in a capital raising transaction for cash, subject to certain exceptions, to maintain its proportionate ownership percentage in the Company. Pursuant to the DSM Stockholder Agreement, DSM agreed <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> to sell or transfer any of the Series B Preferred Stock or warrants purchased by DSM in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Offerings (as defined below), or any shares of common stock issuable upon conversion or exercise thereof, other than to its affiliates, without the consent of the Company through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2018 </div>and to any competitor of the Company thereafter. DSM also agreed that, subject to certain exceptions, until <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> months after there is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> DSM director on the Board, DSM will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not,</div> without the prior consent of the Board, acquire common stock or rights to acquire common stock that would result in DSM beneficially owning more than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">33%</div> of the Company&#x2019;s outstanding voting securities at the time of acquisition. Under the DSM Stockholder Agreement, the Company agreed to use its commercially reasonable efforts to register, via <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> or more registration statements filed with the Securities and Exchange Commission (SEC) under the Securities Act of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1933,</div> as amended (Securities Act), the shares of common stock issuable upon conversion or exercise of the securities purchased by DSM in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Offerings. The Amended and Restated DSM Stockholder Agreement provides that (i) DSM has the right to designate a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">second</div> director to the Board, subject to certain restrictions and a minimum beneficial ownership level of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10%,</div> and (ii) the shares of common stock issuable upon conversion or exercise of the securities purchased by DSM in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Offering are (a) entitled to the registration rights provided for in the DSM Stockholder Agreement and (b) subject to the transfer restrictions set forth in the DSM Stockholder Agreement.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">In addition, pursuant to the Amended and Restated DSM Stockholder Agreement, the Company and DSM agreed to negotiate in good faith regarding an agreement concerning the development of certain products in the Health &amp; Wellness field and, in the event that the parties did <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> reach such agreement prior to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">90</div> days after the closing of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Offering (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Closing), (a) certain exclusive negotiating rights granted to DSM in connection with the entry into the DSM Stockholder Agreement would expire and (b) on the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> anniversary of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Closing and each subsequent anniversary thereof, the Company would make a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.0</div> million cash payment to DSM, provided that the aggregate amount of such payments would <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> exceed <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$25.0</div> million. In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 2017, </div>the Company and DSM entered into such agreement, and in connection therewith an intellectual property escrow agreement relating to certain intellectual property licenses granted by the Company to DSM upon the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Closing became effective.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"></div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">In connection with the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Offering and its <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$25.9</div> million in net proceeds, the Company also entered into a separate intellectual property license with DSM for consideration of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$9.0</div> million in cash, which DSM remitted to the Company on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 28, 2017, </div>and a credit letter (DSM Credit Letter) to be applied against future collaboration and royalty payments owed by DSM to the Company beginning in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018.</div> The DSM Credit Letter had a fair value of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$7.1</div> million and was recorded as deferred revenue on the transaction date. The total fixed consideration of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$34.0</div> million was allocated to each of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Series B Preferred Stock, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Cash Warrant, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Dilution Warrant and DSM Credit Letter at fair value based on level <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div> inputs. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Series B Preferred Stock was recognized at its fair value on the date of issuance of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$15.6</div> million, net of issuance costs of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.2</div> million. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Make-Whole Payment met the criteria to be classified in permanent equity and was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> bifurcated from the preferred stock but will be recognized as a deemed dividend upon conversion, increasing the net loss attributable to Amyris, Inc. common stockholders. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Cash Warrant and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Dilution Warrant are freestanding financial instruments and were initially recognized at their fair value of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$10.6</div> million. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Cash Warrant and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Dilution Warrant have been reported together as derivative liabilities. Changes in the fair value of the warrant derivatives for the years ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div> have been recorded in earnings as a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$7.5</div> million loss and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.0</div> million loss, respectively.</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"></div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> all the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Series B Preferred Shares have been converted into common stock.</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 7pt 0pt 0"></div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">The DSM Credit Letter was initially recorded as deferred revenue at its <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$7.1</div> million fair value, which was determined based on the assumptions that DSM would realize its credit over the next <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18</div> months to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4</div> years with a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50%</div> to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">90%</div> likelihood the credit will be utilized, fully discounted at the Company's <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8.6%</div> average cost of debt. After allocating the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$34.0</div> million in fixed consideration to the financial instruments noted above and the DSM Credit Letter, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$7.8</div> million was available for recognition as revenue related to the intellectual property licenses delivered to DSM, of which <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.3</div> million was recognized as license revenue during the year ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017. </div>The DSM Credit Letter was terminated in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2017, </div>resulting in the reversal of the remaining unrecognized <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.5</div> million deferred revenue liability previously recorded as consideration for the DSM License and Collaboration transaction. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> &#x201c;Revenue Recognition&#x201d; for additional information.</div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; color: #231F20"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Offering</div></div></div><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;"> &#x2013; <div style="display: inline; color: #231F20">Related Party</div></div></div></div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 3, 2017, </div>the Company issued and sold the following securities to Vivo in a private placement (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Offering), resulting in net proceeds to the Company of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$24.8</div> million after payment of offering expenses.</div> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; min-width: 700px;"> <tr style="vertical-align: top"> <td style="width: 57pt">&nbsp;</td> <td style="width: 18pt">&#x2022;</td> <td><div style="display: inline; color: #231F20"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,826,711</div> shares of common stock at a price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.26</div> per share;</div></td> </tr> </table> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; min-width: 700px;"> <tr style="vertical-align: top"> <td style="width: 57pt">&nbsp;</td> <td style="width: 18pt">&#x2022;</td> <td><div style="display: inline; color: #231F20"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,958</div> shares of Series D Preferred Stock at a price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1,000</div> per share;</div></td> </tr> </table> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; min-width: 700px;"> <tr style="vertical-align: top"> <td style="width: 57pt">&nbsp;</td> <td style="width: 18pt">&#x2022;</td> <td style="text-align: justify"><div style="display: inline; color: #231F20">warrants to purchase an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,575,118</div> shares of common stock at an initial exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.39</div> per share, expiring in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">five</div> years (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Cash Warrants); and</div></td> </tr> </table> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; min-width: 700px;"> <tr style="vertical-align: top"> <td style="width: 57pt">&nbsp;</td> <td style="width: 18pt">&#x2022;</td> <td><div style="display: inline; color: #231F20">the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Dilution Warrants (as described below).</div></td> </tr> </table> <div style=" font-size: 10pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"><div style="display: inline; color: #231F20">Each share of Series D Preferred Stock has a stated value of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1,000</div> and, subject to the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Offering Beneficial Ownership Limitation (as defined below), is convertible at any time, at the option of the holders, into common stock at a conversion price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.26</div> per share. The Series D Conversion Rate is subject to adjustment in the event of any dividends or distributions of the common stock, or a</div>ny stock split, reverse stock split, recapitalization, reorganization or similar transaction.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"><div style="display: inline; color: #231F20">Prior </div>to declaring any dividend or other distribution of its assets to holders of common stock, the Company shall <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> declare a dividend per share on the Series D Preferred Stock equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.0001</div> per share. In addition, the Series D Preferred Stock will be entitled to participate with the common stock on an as-converted basis with respect to any dividends or other distributions to holders of common stock. There were <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> dividends declared as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> or <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"><div style="display: inline; color: #231F20">Unless</div> and until converted into common stock in accordance with its terms, the Series D Preferred Stock has <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> voting rights, other than as required by law or with respect to matters specifically affecting the Series D Preferred Stock. <div style="display: inline; color: #231F20">The Series D Preferred Stock is classified as permanent equity, as the Company controls all actions or events required to settle the optional conversion feature in shares.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Cash Warrants and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Dilution Warrants are freestanding derivative instruments in connection with the issuance of equity instruments, which have been recorded as derivative liabilities. These warrants were recognized at their initial fair value upon issuance of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$13.0</div> million as determined by management with the assistance of an independent <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">third</div> party appraisal based on level <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div> inputs. Changes in the fair value of these derivative liabilities from the date of issuance through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> have been recorded in earnings, with losses of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$7.7</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.0</div> million recorded for the years ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> respectively. The remaining <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$12.0</div> million of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$25.0</div> million in gross proceeds received was allocated on a relative fair value basis, resulting in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.6</div> million of proceeds, net of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.2</div> million in issuance costs being allocated to the common stock sold in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Offering and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.2</div> million allocated to the Series D Preferred Stock. The Series D Preferred Stock includes a beneficial conversion feature of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.8</div> million as the full fair value of the Series D Preferred Stock of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$12.0</div> million was greater than the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.2</div> million allocated to the Series D Preferred Stock. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.8</div> million beneficial conversation feature was recorded as a reduction to Additional Paid in Capital and a deemed dividend increasing net loss attributable to Amyris, Inc. common stockholders upon conversion in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">third</div> quarter of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0; color: #231F20">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">At <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,280</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,958</div> shares, respectively of Series D Preferred Stock were outstanding. In the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">third</div> quarter of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> Vivo converted <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,678</div> shares of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Offerings Series D Preferred Stock and the Company recognized a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.8</div> million deemed dividend for the unamortized discounts created from the allocation of proceeds, as a reduction to Additional Paid in Capital and increasing net loss attributable to Amyris, Inc. common stockholders.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0; color: #231F20">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"><div style="display: inline; color: #231F20">In the event of a Fundamental Transaction, the holders of the Series D Preferred Stock will have the right to receive the consider</div>ation receivable as a result of such Fundamental Transaction by a holder of the number of shares of common stock for which the Series D Preferred Stock is convertible immediately prior to such Fundamental Transaction (without regard to whether such Series D Preferred Stock is convertible at such time), which amount shall be paid <div style="display: inline; font-style: italic;">pari passu</div> with all holders of common stock. A Fundamental Transaction is defined in the Certificate of Designation of Preferences, Rights and Limitations relating to the Series D Preferred Stock as any of the following: (i) merger with or consolidation into another legal entity; (ii) sale, lease, license, assignment, transfer or other disposition of all or substantially all of the Company&#x2019;s assets in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> or a series of related transactions; (iii) purchase offer, tender offer or exchange offer of the Company&#x2019;s common stock pursuant to which holders of the Company&#x2019;s common stock are permitted to sell, tender or exchange their shares for other securities, cash or property and has been accepted by the holders of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50%</div> or more of the outstanding common stock; (iv) reclassification, reorganization or recapitalization of the Company&#x2019;s stock; or (v) stock or share purchase agreement that results in another party acquiring more than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50%</div> of the Company&#x2019;s outstanding shares of common stock.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 32pt; margin: 0pt 8pt 0pt 7pt">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">Upon any liquidation, dissolution or winding-up of the Company, the holders of the Series D Preferred Stock shall be entitled to receive out of the assets of the Company the same amount that a holder of common stock would receive if the Series D Preferred Stock were fully converted to common stock immediately prior to such liquidation, dissolution or winding-up (without regard to whether such Series D Preferred Stock is convertible at such time), which amount shall be paid pari passu with all holders of common stock.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">The conversion of the Series D Preferred Stock is subject to a beneficial ownership limitation of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9.99%</div> (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Offering Beneficial Ownership Limitation), which limitation <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be waived by the holders on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">61</div> days&#x2019; prior notice.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">The exercise price of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Cash Warrants is subject to standard adjustments as well as full-ratchet anti-dilution protection for any issuance by the Company of equity or equity-linked securities during the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div>-year period following <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 3, 2017 (</div>Vivo Dilution Period) at a per share price less than the then-current exercise price of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Cash Warrants, subject to certain exceptions. In connection with the entry by the Company and Vivo into warrant exercise agreements in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2018 </div>and related transactions (see <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> &#x201c;August 2018 </div>Warrant Transactions&#x201d; above), the Company and Vivo amended the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Cash Warrants to&nbsp;(i) reduce the exercise price of such warrants from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.39</div> per share to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.40</div> per share and (ii) remove the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Offering Beneficial Ownership Limitation from such warrants.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Dilution Warrants allow Vivo to purchase a number of shares of common stock sufficient to provide Vivo with full-ratchet anti-dilution protection for any issuance by the Company of equity or equity-linked securities during the Vivo Dilution Period at a per share price less than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.26,</div> the effective per share price paid by Vivo for the shares of common stock issuable upon conversion of the Series D Preferred Stock, subject to certain exceptions and subject to the Dilution Floor. The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Dilution Warrants expire <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">five</div> years from the date they are initially exercisable.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"></div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2017, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">none</div> of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Warrants were exercised. As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,575,118</div> of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Cash Warrants had been exercised and the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Dilution Warrants were <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> exercisable for any shares upon cancellation as part of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2018 </div>transaction. See <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> &#x201c;August 2018 </div>Warrant Transactions&#x201d; above regarding the exercise of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Cash Warrants and the cancellation of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Dilution Warrants.</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"></div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">In connection with the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Offering, the Company agreed that it would <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> issue any shares of common stock or securities convertible into or exercisable or exchangeable for common stock at a price below the Dilution Floor without Vivo's consent.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 7pt 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"><div style="display: inline; color: #231F20">In connection with the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Offering, the Company and Vivo also entered into a Stockholder Agreement (Vivo Stockholder Agreement) setting forth certain rights and obligations of Vivo and the Company. Pursuant to the Vivo Stockholder Agreement, Vivo will have the right, subject to certain restrictions and a minimum beneficial ownership level of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.5%,</div> to (i) designate <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> director selected by Vivo to the Board and (ii) appoint </div>a representative to attend all Board meetings in a nonvoting observer capacity and to receive copies of all materials provided to directors, subject to certain exceptions<div style="display: inline; color: #231F20">. Furthermore, Vivo will have the right to purchase additional shares of capital stock of the Company in connection with a sale of equity or equity-linked securities by the Company in a capital raising transaction for cash, subject to certain exceptions, to maintain its proportionate ownership percentage in the Company. Vivo agreed <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> to sell or transfer any of the shares of common stock, Series D Preferred Stock or warrants purchased by Vivo in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Offering, or any shares of common stock issuable upon conversion or exercise thereof, other than to its affiliates, without the consent of the Company through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2018 </div>and to any</div> competitor of the Company thereafter<div style="display: inline; color: #231F20">. </div>Vivo also agreed that, subject to certain exceptions, until the later of (i) <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> years from the closing of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Offering and (ii) <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> months after there is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> Vivo director on the Board, Vivo will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not,</div> without the prior consent of the Board, acquire common stock or rights to acquire common stock that would result in Vivo beneficially owning more than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">33%</div> of the Company&#x2019;s outstanding voting securities at the time of acquisition. Under the Vivo Stockholder Agreement, the Company agreed to use its commercially reasonable efforts to register, via <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> or more registration statements filed with the SEC under the Securities Act, the shares of common stock purchased in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Offering as well as the shares of common stock issuable upon conversion or exercise of the Series D Preferred Stock and warrants purchased by Vivo in the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>Vivo Offering.</div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"><div style="display: inline; color: #231F20"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div></div></div></div><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Exchange <div style="display: inline; color: #231F20">of Common Stock for Series C Convertible Preferred Stock - Related Party</div></div></div></div> <div style=" font-size: 10pt; margin: 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017, </div>Foris and Naxyris agreed to exchange (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Exchange) their outstanding shares of common stock, representing a total of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,394,706</div> shares, for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">20,921</div> shares of the Company's Series C Convertible Preferred Stock, par value <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.0001</div> per share (Series C Preferred Stock) in a private exchange.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">Each share of Series C Preferred Stock had a stated value of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1,000</div> and would automatically convert into common stock, at a conversion price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$15.00</div> per share (Series C Conversion Rate), upon the approval by the Company's stockholders and implementation of a reverse stock split.</div> <div style=" font-size: 10pt; text-indent: 0.5in; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"><div style="display: inline; color: #231F20">The shares of Series C Preferred Stock automatically converted to common stock on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 6, 2017 </div>in connection with the </div>effectiveness of the Reverse Stock Split. The Company accounted for the Series C Preferred Stock and the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Exchange as a non-monetary transaction that had <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> impact on the consolidated financial statements.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0">&nbsp;</div> <div style=" color: #231F20; font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2015 </div>PIPE Warrants</div></div></div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"><div style="display: inline; color: #231F20">In</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 2015, </div>the Company entered into a securities purchase agreement with certain purchasers, including entities affiliated with members of the Board, under which the Company agreed to sell <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,068,379</div> shares of common stock at a price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$23.40</div> per share, for aggregate proceeds to the Company of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$25.0</div> million. In connection with the sale, the Company granted to each of the purchasers a warrant, exercisable at a price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.15</div> per share, to purchase of a number of shares of common stock equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10%</div> of the shares of common stock purchased by such investor. As of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> such warrants had been exercised with respect to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25,643</div> shares of common stock and warrants with respect to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">81,197</div> shares of common stock were outstanding.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"></div> <div style=" color: #231F20; font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">For information regarding issuances of equity securities subsequent to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018,</div> see Part II, Item <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,</div> &#x201c;Subsequent Events&#x201d;.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;"></div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Right of First Investment to Certain Investors</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22.5pt; margin: 0pt 7pt 0pt 0">In connection with investments in the Company has granted certain investors, including Vivo and DSM, a right of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> investment if the Company proposes to sell securities in certain financing transactions. With these rights, such investors <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>subscribe for a portion of any such new financing and require the Company to comply with certain notice periods, which could discourage other investors from participating in, or cause delays in its ability to close, such a financing.</div></div> 41000000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font-size: 10pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16.</div> Subsequent Events</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Extension and Exchange of Tranche II Note</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 14, 2019, </div>Wolverine Flagship Fund Trading Limited (Wolverine) agreed to waive payment of the Tranche II Note held by Wolverine (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> &#x201c;Debt&#x201d;) at maturity until <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 15, 2019 </div>in exchange for a fee, payable on or prior to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 15, 2019, </div>of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.6</div> million. Effective <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 15, 2019, </div>the due date of the waiver fee was extended to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 13, 2019 </div>and will bear interest at a rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1.75%</div> per month, compounded, from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 16, 2019 </div>to the date of payment.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Evergreen Shares for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> Equity Incentive Plan and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> Employee Stock Purchase Plan</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> February 2019, </div>the Company's Board of Directors (the Board) approved increases to the number of shares available for issuance under the Company's <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> Equity Incentive Plan (the Equity Plan) and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2010</div> Employee Stock Purchase Plan (the Purchase Plan). These shares in connection with the Equity Plan represented an automatic annual increase in the number of shares available for grant and issuance under the Equity Plan of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,828,241</div> shares. This increase is equal to approximately <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5.0%</div> of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">76,564,829</div> total outstanding shares of the Company&#x2019;s common stock as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018.</div> This automatic increase was effective as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2019. </div>These shares in connection with the Purchase Plan represented an automatic annual increase in the number of shares reserved for issuance under the Purchase Plan of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">382,824</div> shares. This increase is equal to approximately <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">0.5%</div> of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">76,564,829</div> total outstanding shares of the Company&#x2019;s common stock as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018.</div> This automatic increase was effective as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2019.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Cannabinoid Agreement</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">&nbsp;</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 18, 2019, </div>the Company entered into a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$300</div> million research, collaboration and license agreement (the Cannabinoid Agreement) with LAVVAN, Inc., a newly formed investment-backed company (Lavvan), for the development, manufacture and commercialization of cannabinoids. Under the agreement, the Company would perform research and development activities and Lavvan would be responsible for the commercialization of the cannabinoids developed under the agreement. The Cannabinoid Agreement is being principally funded on a milestone basis, with the Company also entitled to receive certain supplementary research and development funding from Lavvan. The Company could receive aggregate funding of up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$300</div> million over the term of the Cannabinoid Agreement if all of the milestones are achieved. Additionally, the agreement provides for profit share to the Company on Lavvan's gross profit margin once products are commercialized; these payments will be due for the next <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">20</div> years. The consummation of the transactions contemplated by the Cannabinoid Agreement is subject to certain conditions, including obtaining certain <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">third</div> party consents and releases and the repayment or refinancing of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes and the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> &#x201c;Debt&#x201d;). On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2, 2019, </div>the parties consummated the transactions contemplated by the Cannabinoid Agreement, including the formation of a special purpose entity to hold certain intellectual property created during the collaboration (the Cannabinoid Collaboration IP), the licensing of certain Company intellectual property to Lavvan, the licensing of the Cannabinoid Collaboration IP to the Company and Lavvan, and the granting by the Company to Lavvan of a lien on the Company background intellectual property being licensed to Lavvan under the Cannabinoid Agreement, which lien would be subordinated to the lien on such intellectual property under the GACP Term Loan Facility (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> &#x201c;Debt&#x201d;).</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div><div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">LSA Amendments, Assignment and Waivers</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 4, 2019, </div>the Company and GACP amended the LSA (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> &#x201c;Debt&#x201d;) to (i) effective <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018, </div>eliminate the conditions giving rise to the early maturity date, so that loans under the GACP Term Loan Facilities would have a maturity date of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 1, 2021, (</div>ii) remove certain Company intellectual property related to the Cannabinoid Agreement from the lien granted by the Company to GACP under the LSA, (iii) eliminate the Company&#x2019;s ability to obtain the Incremental GACP Term Loan Facility, (iv) eliminate the Company&#x2019;s reinvestment rights with respect to mandatory prepayments upon asset sales, (v) restrict the Company&#x2019;s ability to pay interest and principal on other indebtedness without the consent of GACP, and (vi) provide that the Company must have at all times at least <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$15</div> million of unrestricted, unencumbered cash subject to a control agreement in favor of GACP.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 4, 2019, </div>the Company and GACP entered into a waiver agreement, pursuant to which GACP agreed to waive breaches of certain covenants under the LSA occurring prior to, as of and after <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018 </div>through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 8, 2019, </div>including covenants related to quarterly minimum revenues, minimum liquidity amounts and a minimum asset coverage ratio. In connection with such waiver, the Company agreed to pay GACP fees of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.8</div> million.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 15, 2019, </div>the Company, GACP and Foris Ventures, LLC (Foris, an entity affiliated with director John Doerr of Kleiner Perkins Caufield &amp; Byers, a current stockholder, and an owner of greater than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">five</div> percent of the Company&#x2019;s outstanding common stock) entered into a Loan Purchase Agreement, pursuant to which Foris agreed to purchase and assume from GACP, and GACP agreed to sell and assign to Foris, the outstanding loans under the LSA and all documents and assets related thereto. In connection with such purchase and assignment, the Company agreed to repay Foris <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.5</div> million of the purchase price paid by Foris to GACP (the Company LPA Obligation). The closing of the loan purchase and assignment occurred on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 16, 2019.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 14, 2019, </div>the Company and Foris entered into an Amendment <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">No</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5</div> and Waiver to the LSA (the LSA Amendment and Waiver), pursuant to which (i) the maturity date of the loans under the LSA was extended from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 1, 2021 </div>to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 1, 2022, (</div>ii) the interest rate for the loans under the LSA was modified from the sum of (A) the greater of (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">x</div>) the prime rate as reported in the Wall Street Journal or (y)&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.75%</div> plus (B)&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9%</div> to the greater of (A) <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12%</div> or (B) the rate of interest payable with respect to any indebtedness of the Company, (iii) the amortization of the loans under the LSA was delayed until <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 16, 2019, (</div>iv) certain accrued and future interest and agency fee payments under the LSA were delayed until <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 16, 2019, (</div>v) certain covenants under the LSA, including related definitions, were amended to provide the Company with greater operational and financial flexibility, including, without limitation, to permit the incurrence of the indebtedness under the Naxyris Loan Facility (as described below) and the granting of liens with respect thereto, subject to the terms of an intercreditor agreement between Foris and Naxyris S.A. (Naxyris) governing the respective rights of the parties with respect to, among other things, the assets securing the Naxyris Loan Agreement and the LSA (the Intercreditor Agreement), (vi) certain outstanding unsecured promissory notes issued by the Company to Foris on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 8, 2019, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 11, 2019, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 10, 2019 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 26, 2019 (</div>as described below under &#x201c;Foris Credit Agreements&#x201d;), in an aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$32.5</div> million, as well as the Company LPA Obligation, were added to the loans under the LSA, made subject to the LSA and secured by the security interest in the collateral granted to Foris under the LSA, and such promissory notes and contractual obligation were cancelled in connection therewith, and (vii) Foris agreed to waive certain existing defaults under the LSA. After giving effect to the LSA Amendment and Waiver, there is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$71.0</div> million aggregate principal amount of loans outstanding under the LSA, including with respect to covenants related to quarterly minimum revenues, minimum liquidity amounts and a minimum asset coverage ratio. In connection with the entry into the LSA Amendment and Waiver, on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 14, 2019 </div>the Company issued to Foris a warrant to purchase up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,438,829</div> shares of Common Stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.87</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance. Pursuant to the terms of the warrant, Foris <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> exercise the Foris Warrant to the extent that, after giving effect to such exercise, Foris, together with its affiliates, would beneficially own in excess of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19.99%</div> of the number of shares of common stock outstanding after giving effect to such exercise, unless the Company has obtained stockholder approval to exceed such limit in accordance with Nasdaq&nbsp;rules and regulations, which the Company intends to seek at its <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> annual meeting of stockholders.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Foris Credit Agreements</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 8, 2019, </div>the Company and Foris entered into an agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.0</div> million, which the Company borrowed in full on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 8, 2019 </div>and issued to Foris a promissory note in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.0</div> million (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Note). The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Note has a maturity date of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 14, 2019. </div>In connection with the entry into the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Credit Agreement and the issuance of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Note, which has <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> stated interest rate, the Company agreed to pay Foris a fee of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.0</div> million, payable on or prior to the maturity date of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Note (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Note Fee); provided, that the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Note Fee would be reduced to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.5</div> million if the Company repaid the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Note in full by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 15, 2019. </div>The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Note is subordinated in right of payment to the Tranche II Note held by Wolverine (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> &#x201c;Debt&#x201d; and above in this Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> &#x201c;Subsequent Events&#x201d;).</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 11, 2019, </div>the Company and Foris entered into an agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.5</div> million, which the Company borrowed in full on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 11, 2019 </div>and issued to Foris a promissory note in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.5</div> million (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June </div>Foris Note). The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June </div>Foris Note (i) accrues interest at a rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12.5%</div> per annum from and including <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 11, 2019, </div>which interest is payable on the maturity date or the earlier repayment or other satisfaction of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June </div>Foris Note, and (ii) matures on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 28, 2019; </div>provided, that if the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 2017 </div>Cash Warrant held by DSM and the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2017 </div>DSM Cash Warrant (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,</div> &#x201c;Stockholders&#x2019; Deficit&#x201d;) are exercised,&nbsp;then the maturity date of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June </div>Foris Note will be the business day immediately following such exercise.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 10, 2019, </div>the Company and Foris entered into a credit agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$16.0</div> million (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July </div>Foris Credit Agreement), of which the Company borrowed <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.0</div> million on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 10, 2019 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.0</div> million on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 26, 2019 </div>and issued to Foris promissory notes, each in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.0</div> million, on such dates (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July </div>Foris Notes). The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July </div>Foris Notes (i) accrue interest at a rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12.5%</div> per annum from and including the respective date of issuance, which interest is payable on the maturity date or the earlier repayment or other satisfaction of the applicable <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July </div>Foris Note, and (ii) mature on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2019. </div>In connection with the entry into the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July </div>Foris Credit Agreement, the Company and Foris amended the warrant issued to Foris on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 17, 2018 (</div>see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,</div> &#x201c;Stockholders&#x2019; Deficit&#x201d;) to reduce the exercise price of such warrant from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$7.52</div> per share to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.87</div> per share.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>at its option repay the amounts outstanding under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Note (including the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Note Fee), the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June </div>Foris Note and the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July </div>Foris Notes before their respective maturity dates, in whole or in part, at a price equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100%</div> of the amount being repaid plus, in the case of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June </div>Foris Note and the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July </div>Foris Notes, accrued and unpaid interest on such amount to the date of repayment.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 14, 2019, </div>the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April </div>Foris Note, the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June </div>Foris Note and the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July </div>Foris Notes were added to the loans under the LSA, made subject to the LSA and secured by the security interest in the collateral granted to Foris under the LSA, and such notes were cancelled in connection therewith. See above under &#x201c;LSA Amendments, Assignment and Waivers&#x201d; for additional information.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 28, 2019, </div>the Company and Foris entered into a credit agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$19.0</div> million (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August </div>Foris Credit Agreement), which the Company borrowed in full on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 28, 2019 </div>and issued to Foris a promissory note in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$19.0</div> million (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August </div>Foris Note). The <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August </div>Foris Note (i) accrues interest at a rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12%</div> per annum from and including <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 28, 2019, </div>which interest is payable quarterly in arrears on each <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 31, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 30, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 30 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, </div>beginning <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2019, </div>and (ii) matures on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2023. </div>The Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>at its option repay the amounts outstanding under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August </div>Foris Note before the maturity date, in whole or in part, at a price equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100%</div> of the amount being repaid plus accrued and unpaid interest on such amount to the date of repayment.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In connection with the entry into the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August </div>Foris Credit Agreement, on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 28, 2019 </div>the Company issued to Foris a warrant to purchase up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,871,795</div> shares of Common Stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.90</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance in a private placement pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div>) of the Securities Act of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1933,</div> as amended (the Securities Act), and Regulation D promulgated under the Securities Act. The exercise price of the warrant is subject to standard adjustments but does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> contain any anti-dilution protection, and the warrants only permit &#x201c;cashless&#x201d; or &#x201c;net&#x201d; exercise after the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">six</div>-month anniversary of issuance of the applicable warrant, and only to the extent that there is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, Foris <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> exercise the warrant to the extent that, after giving effect to such exercise, Foris, together with its affiliates, would beneficially own in excess of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19.99%</div> of the number of shares of common stock outstanding after giving effect to such exercise, unless the Company has obtained stockholder approval to exceed such limit in accordance with Nasdaq&nbsp;rules and regulations, which the Company intends to seek at its <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> annual meeting of stockholders.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Private Placements</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">16,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019,</div> the Company sold and issued to Foris <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,732,369</div> shares of common stock at a price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.87</div> per share, as well as a warrant to purchase up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,424,804</div> shares of common stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.87</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance, in a private placement pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div>) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$20.0</div> million (the Foris Investment). The Company used the proceeds from the Foris Investment to repay a portion of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> &#x201c;Debt&#x201d;).</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 26, 2019, </div>the Company sold and issued (i) <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,832,440</div> shares of common stock at a price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.12</div> per share, as well as a warrant to purchase up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,983,230</div> shares of common stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.12</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance, to Foris and (ii) an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,043,781</div> shares of common stock at a price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.02</div> per share, as well as warrants to purchase up to an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,635,025</div> shares of common stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.02</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance, to certain other non-affiliated investors, in each case in private placements pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div>) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$23.2</div> million. On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 28, 2019, </div>in connection with the entry into the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August </div>Foris Credit Agreement (as described above under "Foris Credit Agreements"), the Company and Foris amended the warrant issued to Foris on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 26, 2019 </div>to reduce the exercise price of such warrant from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.12</div> per share to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.90</div> per share.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 29, 2019, </div>the Company sold and issued (i) <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">913,529</div> shares of common stock at a price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.76</div> per share, as well as a warrant to purchase up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,212,787</div> shares of common stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.76</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance, to Vivo and (ii) an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">323,382</div> shares of common stock at a price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.02</div> per share, as well as warrants to purchase up to an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">258,704</div> shares of common stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.02</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance, to certain other non-affiliated investors, in each case in private placements pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div>) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.8</div> million.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 3, 2019, </div>the Company sold and issued <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,243,781</div> shares of common stock at a price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.02</div> per share, as well as a warrant to purchase up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">995,024</div> shares of common stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.02</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance, to a non-affiliated investor in a private placement pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div>) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5</div> million.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The exercise price of the warrants issued in the foregoing private placements is subject to standard adjustments but does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> contain any anti-dilution protection, and the warrants only permit &#x201c;cashless&#x201d; or &#x201c;net&#x201d; exercise after the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">six</div>-month anniversary of issuance of the applicable warrant, and only to the extent that there is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, in connection with the foregoing private placements, the Company agreed <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> to effect any exercise or conversion of any Company security, and the investors agreed <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> to exercise or convert any portion of any Company security, to the extent that after giving effect to such exercise or conversion, the applicable investor, together with its affiliates, would beneficially own in excess of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19.99%</div> of the number of shares of common stock outstanding immediately after giving effect to such exercise or conversion, and the warrants contained a similar limitation. The Company intends to seek stockholder approval for Foris to exceed such limitation in accordance with Nasdaq&nbsp;rules and regulations at its <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> annual meeting of stockholders.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">DSM Agreements</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 16, 2019, </div>the Company assigned to DSM, and DSM assumed, all of the Company&#x2019;s rights and obligations under the Value Sharing Agreement (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> &#x201c;Revenue Recognition&#x201d;), for aggregate consideration to the Company of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$57.0</div> million, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$29.1</div> million of which was paid to the Company in cash, with the remaining <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$27.9</div> million being used to pay certain existing obligations of the Company to DSM, including certain obligations under the Supply Agreement Amendment (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> &#x201c;Revenue Recognition&#x201d;). The Company used a majority of the cash proceeds to repay a portion of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2015</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> &#x201c;Debt&#x201d;).</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In addition, on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 16, 2019 </div>the Company and DSM entered into amendments to the Supply Agreement and the Performance Agreement (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> &#x201c;Revenue Recognition&#x201d;), as well as the Quota Purchase Agreement relating to the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2017 </div>sale of Amyris Brasil to DSM (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,</div> &#x201c;Divestiture&#x201d; and Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,</div> "Related Party Transactions"), pursuant to which (i) DSM agreed to reduce certain manufacturing costs and fees paid by the Company related to the production of farnesene under the Supply Agreement through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021,</div> as well as remove the priority of certain customers over the Company with respect to production capacity at the Brotas, Brazil facility, (ii) the Company agreed to provide DSM rights to conduct certain process and downstream recovery improvements under the Performance Agreement at facilities other than the Brotas, Brazil facility in exchange for DSM providing the Company with a license to such improvements and (iii) the Company released DSM from its obligation to provide manufacturing and support services under the Quota Purchase Agreement in connection with the Company&#x2019;s planned new manufacturing facility, which is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> longer planned to be located at the Brotas, Brazil location.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 17, 2019, </div>the Company and DSM entered into a credit agreement (the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x201c;2019</div> DSM Credit Agreement&#x201d;) to make available to the Company a secured credit facility in an aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.0</div> million, to be issued in separate installments of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.0</div> million, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.0</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.0</div> million, respectively, with each installment being subject to certain closing conditions, including the payment of certain existing obligations of the Company to DSM. On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 17, 2019, </div>the Company borrowed the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> installment of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.0</div> million under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> DSM Credit Agreement, all of which proceeds were used to pay certain existing obligations of the Company to DSM, and issued to DSM a promissory note in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.0</div> million. On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 19, 2019, </div>the Company borrowed the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">second</div> installment of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.0</div> million under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> DSM Credit Agreement, all of which proceeds were used to pay certain existing obligations of the Company to DSM, and issued to DSM a promissory note in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.0</div> million. On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 23, 2019, </div>the Company borrowed the final installment of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.0</div> million under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> DSM Credit Agreement, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.5</div> million of which proceeds were used to pay certain existing obligations of the Company to DSM, and issued to DSM a promissory note in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.0</div> million. The promissory notes issued under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> DSM Credit Agreement (i) mature on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 7, 2022, (</div>ii) accrue interest at a rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12.5%</div> per annum from and including the applicable date of issuance, which interest is payable quarterly in arrears on each <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> April 1, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 1 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 1, </div>beginning <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2020, </div>and (iii) are secured by a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div>-priority lien on certain Company intellectual property licensed to DSM. The Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>at its option repay the amounts outstanding under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> DSM Credit Agreement before the maturity date, in whole or in part, at a price equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100%</div> of the amount being repaid plus accrued and unpaid interest on such amount to the date of repayment. In addition, the Company is required to repay the amounts outstanding under the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> DSM Credit Agreement (i) in an amount equal to the gross cash proceeds, if any, received by the Company upon the exercise by DSM of any of the common stock purchase warrants issued by the Company to DSM on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 11, 2017 </div>or <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 7, 2017 (</div>see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,</div> &#x201c;Stockholders&#x2019; Deficit&#x201d;) and (ii) in full upon the request of DSM at any time following the receipt by the Company of at least <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$50.0</div> million of gross cash proceeds from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> or more sales of equity securities of the Company on or prior to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 30, 2020.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Raizen Joint Venture Agreement</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 10, 2019, </div>the Company and Raizen Energia S.A. (Raizen) entered into an agreement relating to the formation and operation of a joint venture relating to the production, sale and commercialization of alternative sweetener products. In connection with the formation of the joint venture, among other things, (i) the joint venture will construct a manufacturing facility on land owned by Raizen and leased to the joint venture (the Sweetener Plant), (ii) the Company will grant to the joint venture an exclusive, royalty-free, worldwide, license to certain technology owned by the Company relevant to the joint venture&#x2019;s business, and (iii) the Company and Raizen will enter into a shareholders agreement setting forth the rights and obligations of the parties with respect to, and the management of, the joint venture. The formation of the joint venture is subject to certain conditions, including certain regulatory approvals and the achievement of certain technological and economic milestones relating to the Company&#x2019;s existing production of its alternative sweetener product. If such conditions are <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> satisfied by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2019, </div>the joint venture will automatically terminate. In addition, notwithstanding the satisfaction of the closing conditions, Raizen <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>elect <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> to consummate the formation and operation of the joint venture, in which event, the Company will retain the right to construct and operate the Sweetener Plant.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Upon the closing of the joint venture, each party will make an initial capital contribution to the joint venture of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,500,000</div> Brazilian Real (<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">R$2,500,000</div>) and the joint venture will be owned <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50%</div> by the Company and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">50%</div> by Raizen. Within <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60</div> days of the formation, the parties will make an aggregate cash contribution to the joint venture of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">U.S.$9,000,000</div> to purchase certain fixed assets currently owned by the Company and located at the site of the Company&#x2019;s former joint venture with Sao Martinho S.A. in Pradopolis, Brazil for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">U.S.$3,000,000.</div> In addition, within <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">six</div> months of the formation, the Company will contribute to the joint venture its existing supply agreements related to its alternative sweetener product, subject to certain exceptions, in exchange for shares of dividend-bearing preferred stock in the joint venture, which will be entitled, for a period of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10</div> years commencing from the initial date of operation of the Sweetener Plant, to certain priority fixed cumulative dividends including, in the event that certain technological and economic milestones are met in any fiscal quarter, a percentage of the operating cash flow of the joint venture in such quarter.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">After the formation of the joint venture, the parties will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> conduct activities similar or identical to the joint venture. In the event that certain technological and economic milestones are <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> met in any fiscal year beginning with the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">third</div> fiscal year after formation of the joint venture and ending with the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">seventh</div> fiscal year after formation of the joint venture, Raizen shall have the right to sell all of its shares in the joint venture to the Company at a price per share equal to the higher of the book value and the amount of Raizen&#x2019;s investments in the joint venture, as adjusted for Raizen&#x2019;s cost of capital.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes Exchanges</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 10, 2019, </div>the Company exchanged <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$13.5</div> million aggregate principal amount of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> &#x201c;Debt&#x201d;) held by certain non-affiliated investors, including accrued and unpaid interest thereon up to, but excluding, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 15, 2019, </div>for an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,479,008</div> shares of common stock and warrants to purchase an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,391,603</div> shares of common stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.02</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance, in a private exchange pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9</div>) of the Securities Act.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 14, 2019, </div>the Company exchanged <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.0</div> million aggregate principal amount of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes held by Foris, including accrued and unpaid interest thereon up to, but excluding, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 15, 2019, </div>for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,122,460</div> shares of common stock and a warrant to purchase up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">352,638</div> shares of common stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.56</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance, in a private exchange pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9</div>) of the Securities Act. On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 28, 2019, </div>in connection with the entry into the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August </div>Foris Credit Agreement (as described above under "Foris Credit Agreements"), the Company and Foris amended the warrant issued to Foris on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 14, 2019 </div>to reduce the exercise price of such warrant from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.56</div> per share to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.90</div> per share.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 15, 2019, </div>the Company exchanged <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$10.0</div> million aggregate principal amount of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes held by Maxwell (Mauritius) Pte Ltd for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,500,000</div> shares of common stock in a private exchange pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9</div>) of the Securities Act.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 15, 2019, </div>the Company exchanged <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$9.7</div> million aggregate principal amount of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2014</div> Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144A</div> Convertible Notes held by Total for a new senior convertible note with an equal principal amount and with substantially identical terms, except that the new note had a maturity date of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 14, 2019, </div>in a private exchange pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9</div>) of the Securities Act. Effective <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 14, 2019, </div>the Company and Total agreed to extend the maturity date of the new note from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 14, 2019 </div>to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 18, 2019. </div>Effective <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 18, 2019, </div>the Company and Total agreed to (i) further extend the maturity date of the new note from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 18, 2019 </div>to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 28, 2019 </div>and (ii) increase the interest rate on the new note to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10.5%</div> per annum, beginning <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 18, 2019. </div>Effective <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 28, 2019, </div>the Company and Total agreed to (i) further extend the maturity date of the new note from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 28, 2019 </div>to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 28, 2019 </div>and (ii) increase the interest rate on the new note to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12%</div> per annum, beginning <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 28, 2019.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The exercise price of the warrants issued in the foregoing exchanges is subject to standard adjustments but does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> contain any anti-dilution protection, and the warrants only permit &#x201c;cashless&#x201d; or &#x201c;net&#x201d; exercise after the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">six</div>-month anniversary of the exercisability of the applicable warrant, and only to the extent that there is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, (i) the exercisability of the warrant issued to Foris is subject to stockholder approval in accordance with Nasdaq&nbsp;rules and regulations, which the Company intends to seek at its <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2019</div> annual meeting of stockholders, and (ii) each other warrant provides that the Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> effect any exercise of such warrant to the extent that, after giving effect to such exercise, the applicable holder, together with its affiliates, would beneficially own in excess of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.99%</div> of the number of shares of common stock outstanding after giving effect to such exercise.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> Exchanges</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 15, 2019 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 24, 2019, </div>the Company exchanged <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$53.3</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.7</div> million principal amount, respectively, of the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> &#x201c;Debt&#x201d;), including accrued and unpaid interest thereon, representing all then-outstanding <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021,</div> for new senior convertible notes with an equal principal amount and warrants to purchase up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,000,000</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">181,818</div> shares of common stock, respectively, at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.12</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance, in private exchanges pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9</div>) of the Securities Act. The new notes have substantially identical terms as the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> being exchanged, except that (i) the holders agreed to waive, until <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 22, 2019, </div>certain covenants relating to the effectiveness of the registration statement covering the shares of common stock issuable upon conversion of, or otherwise pursuant to, the new notes and the filing by the Company of reports with the SEC and (ii) during the period from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 22, 2019 </div>to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 29, 2019, </div>inclusive, the holders have the right to require the Company to redeem the new notes, in whole or in part, at a price equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">125%</div> of the principal amount being redeemed. The exercise price of the warrants is subject to standard adjustments but does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> contain any anti-dilution protection, and the warrants only permit &#x201c;cashless&#x201d; or &#x201c;net&#x201d; exercise after the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">six</div>-month anniversary of issuance, and only to the extent that there is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, the holders <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> exercise the warrants, and the Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> effect any exercise of the warrants, to the extent that, after giving effect to such exercise, the applicable holder, together with its affiliates, would beneficially own in excess of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.99%</div> of the number of shares of common stock outstanding after giving effect to such exercise.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 26, 2019, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> of the holders of the senior convertibles notes issued in exchange for the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Notes due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021,</div> holding a senior convertible note in the principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.7</div> million, exercised its right to require the Company to redeem such note in whole at a price equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">125%</div> of the principal amount being redeemed, plus accrued and unpaid interest on such note to the date of repayment. Redemption of such note was initially due on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 30, 2019 </div>and subsequently extended to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 30, 2019. </div>The Company redeemed such note in full on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 30, 2019.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 24, 2019, </div>Company further exchanged <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$53.3</div> million principal amount of the previously-exchanged <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> Convertible Senior Notes due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2021</div> as well as the warrant to purchase up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,000,000</div> shares of common stock issued on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 15, 2019, </div>for a new senior convertible note with a principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$68.3</div> million (the Second Exchange Note) and a new warrant to purchase up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,000,000</div> shares of common stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.87</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 15, 2019 (</div>the Second Exchange Warrant) in a private exchange pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9</div>) of the Securities Act. The Second Exchange Note and Second Exchange Warrant have substantially similar terms as the note and warrant, respectively, issued on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> May 15, 2019, </div>except that (i) the principal amount of the Second Exchange Note would be <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$68.3</div> million, reflecting accrued and unpaid interest and late charges under the exchanged note and a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25%</div> premium accruing as a result of the Company&#x2019;s failure to make an installment payment on the exchanged note due <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 1, 2019 </div>in the amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.4</div> million, provided that upon an event of default under the Second Exchange Note, the Company would <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> be required to redeem the Second Exchange Note in cash at a price greater than&nbsp;the intrinsic value of the shares of common stock underlying the Second Exchange Note, (ii) the Second Exchange Note bears interest at a rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">18%</div> per annum, (iii) the holder agreed to extend its waiver of certain covenant breaches relating to the failure by the Company to timely file periodic reports with the SEC from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 22, 2019 </div>to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 16, 2019, (</div>iv) the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> installment date under the Second Exchange Note will occur on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> October 1, 2019, (</div>v) the Company is required to (A) make principal payments on the Second Exchange Note in the amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.2</div> million on each of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2, 2019 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 22, 2019, </div>and (B) pay all remaining amounts then outstanding under the Second Exchange Note on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 16, 2019, </div>and if the Company fails to make any such payment on the applicable payment date, the conversion price of the Second Exchange Note will be reset to the volume-weighted average price of the common stock on the trading day immediately following the Company&#x2019;s filing of a Current Report on Form <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8</div>-K with respect to its failure to make the payment due on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 16, 2019, </div>if such volume-weighted average price is lower than the conversion price of the Second Exchange Note then in effect, subject to a price floor and (vi) the Second Exchange Warrant has an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.87</div> per share.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 16, 2019, </div>the Company failed to pay an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$63.6</div> million of outstanding principal and accrued interest on the Second Exchange Note when due. The failure resulted in an event of default under the Second Exchange Note and also triggered cross-defaults under other debt instruments of the Company which permitted the holders of such indebtedness to accelerate the amounts owing under such instruments. The Company subsequently received waivers from substantially all holders of such other debt instruments to waive the right to accelerate. As a result, the indebtedness with respect to which the Company has obtained such waivers continues to be classified as long-term on the Company&#x2019;s balance sheet.&nbsp; The indebtedness reflected by the Second Exchange Note continues to be classified as a current liability on the Company&#x2019;s balance sheet. In addition, as a result of the payment default, the conversion price of the Second Exchange Note is subject to adjustment in accordance with the terms of the Second Exchange Note.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The Company does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> currently have sufficient funds to repay the amounts outstanding under the Second Exchange Note. To date, negotiations with the holder of the Second Exchange Note have <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> been successful, and there can be <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> assurance that a favorable outcome for the Company will be reached. The Company has executed a term sheet with an existing investor for a term loan, the proceeds of which would be used to repay a portion of the Second Exchange Note. However, there can be <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> assurance that the Company will be able to obtain such financing on its expected timeline, or on acceptable terms, if at all. Even if the Company does obtain such financing, it will <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> have sufficient funds to repay the Second Exchange Note in full without obtaining additional financing, which the Company is attempting to source.</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The consolidated financial statements do <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> include any adjustments that might result from the outcome of this uncertainty.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Exchange of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2013 </div>Financing Convertible Note</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 22pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 8, 2019, </div>the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 2013 </div>Financing Convertible Note held by Wolverine (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,</div> &#x201c;Debt&#x201d;) was exchanged for <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,767,632</div> shares of common stock and a warrant to purchase <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,080,000</div> shares of common stock in a private exchange pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9</div>) of the Securities Act. The exercise price of the warrant is subject to standard adjustments but does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> contain any anti-dilution protection, and the warrant only permits &#x201c;cashless&#x201d; or &#x201c;net&#x201d; exercise after the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">six</div>-month anniversary of issuance, and only to the extent that there is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> an effective registration statement covering the resale of the shares of common stock underlying the warrant. In addition, Wolverine <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> exercise the warrant to the extent that, after giving effect to such exercise, Wolverine, together with its affiliates, would beneficially own in excess of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4.99%</div> of the number of shares of common stock outstanding after giving effect to such exercise.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Nikko Loan Agreement</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 29, 2019, </div>the Company and Nikko Chemicals Co., Ltd. (Nikko) entered into a loan agreement (the Nikko Loan Agreement) to make available to the Company secured loans in an aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.0</div> million, to be issued in separate installments of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.0</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.0</div> million, respectively, with each installment being subject to certain closing conditions, including the entry into certain commercial agreements and other arrangements relating to the Aprinnova JV (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,</div> &#x201c;Related Party Transactions&#x201d;). On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 30, 2019, </div>the Company borrowed the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div> installment of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.0</div> million under the Nikko Loan Agreement and received net cash proceeds of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.8</div> million, with the remaining <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.2</div> million being withheld by Nikko as prepayment of the interest payable on such loan through the maturity date. On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 8, 2019, </div>the Company borrowed the remaining <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.0</div> million available under the Nikko Loan Agreement and received net cash proceeds of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.9</div> million, with the remaining <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.1</div> million being withheld by Nikko as prepayment of the interest payable on such loan through the maturity date. The loans (i) mature on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 18, 2020, (</div>ii) accrue interest at a rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5%</div> per annum from and including the applicable loan date through the maturity date, which interest is required to be prepaid in full on the date of the applicable loan, and (iii) are secured by a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">first</div>-priority lien on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12.8%</div> of the Aprinnova JV interests owned by the Company.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Aprinnova Working Capital Loan</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Effective <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 31, 2019, </div>the Company and Nikko agreed to extend the term of the Second Aprinnova Note (see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,</div> &#x201c;Debt&#x201d;) from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 1, 2019 </div>to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 1, 2020.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;">Naxyris Loan and Security Agreement</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 14, 2019, </div>the Company, certain of the Company&#x2019;s subsidiaries (the Subsidiary Guarantors) and, as lender, Naxyris, an existing stockholder of the Company and an investment vehicle owned by Naxos Capital Partners SCA Sicar, which is affiliated with NAXOS S.A.R.L. (Switzerland), for which director Carole Piwnica serves as director, entered into a Loan and Security Agreement (the Naxyris Loan Agreement) to make available to the Company a secured term loan facility in an aggregate principal amount of up to&nbsp;<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$10,435,000</div>&nbsp;(the Naxyris Loan Facility), which the Company borrowed in full on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 14, 2019.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Loans under the Naxyris Loan Facility have a maturity date of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> July 1, 2022 </div>and accrue interest at a rate per annum equal to the greater of (i) <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12%</div> or (ii) the rate of interest payable with respect to any indebtedness of the Company plus <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">25</div> basis points, which interest will be payable monthly in arrears, provided that all interest accruing from and after <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> August 14, 2019 </div>through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 1, 2019 </div>shall be due and payable on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 15, 2019.</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The obligations of the Company under the Naxyris Loan Facility are (i) guaranteed by the Subsidiary Guarantors and (ii) secured by a perfected security interest in substantially all of the assets of the Company and the Subsidiary Guarantors (the Collateral), junior in payment priority to Foris Ventures subject to certain limitations and exceptions, as well as the terms of the Intercreditor Agreement (as defined above).</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">Mandatory prepayments of the outstanding amounts under the Naxyris Loan Facility will be required upon the occurrence of certain events, including asset sales, a change in control, and the incurrence of additional indebtedness, subject to certain exceptions and reinvestment rights.&nbsp;Outstanding amounts under the Naxyris Loan Facility must also be prepaid to the extent that the borrowing base exceeds the outstanding principal amount of the loans under the Naxyris Loan Facility. In addition, the Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>at its option prepay the outstanding principal amount of the loans under the Naxyris Loan Facility in full before the maturity date. Any prepayment of the loans under the Naxyris Loan Facility prior to the maturity date, whether pursuant to a mandatory or optional prepayment, is subject to a prepayment charge equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> year&#x2019;s interest at the then-current interest rate for the Naxyris Loan Facility. Upon the repayment of the loans under the Naxyris loan facility, whether on the maturity date or earlier pursuant to an optional or mandatory prepayment, the Company will pay Naxyris an end of term fee. In addition, (i) the Company will be required to pay a fee equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6%</div> of any amount the Company fails to pay within <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">three</div> business days of its due date and (ii) any interest that is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> paid when due will be added to principal and will bear compound interest at the applicable rate.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">The affirmative and negative covenants in the Naxyris Loan Agreement relate to, among other items: (i) payment of taxes; (ii) financial reporting; (iii) maintenance of insurance; and (iv) limitations on indebtedness, liens, mergers, consolidations and acquisitions, transfers of assets, dividends and other distributions in respect of capital stock, investments, loans and advances, and corporate changes. The Naxyris Loan Agreement also contains financial covenants, including covenants related to minimum revenue, liquidity, and asset coverage.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-style: italic;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 2019 </div>Credit Agreements</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">On <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 10, 2019, </div>the Company entered into separate credit agreements (the &#x201c;Investor Credit Agreements&#x201d;) with each of Schottenfeld Opportunities Fund II, L.P., Phase Five Partners, LP and Koyote Trading, LLC (the &#x201c;Investors&#x201d;) to make available to the Company unsecured credit facilities in an aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$12.5</div> million, which the Company borrowed in full on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 10, 2019 </div>and issued to the Investors separate promissory notes in the aggregate principal amount of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$12.5</div> million (the &#x201c;Investor Notes&#x201d;). Each Investor Note (i) accrues interest at a rate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12%</div> per annum from and including <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 10, 2019, </div>which interest is payable quarterly in arrears on each <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> March 31, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> June 30, </div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 30 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, </div>beginning <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2019, </div>and (ii) matures on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> January 1, 2023. </div>The Company <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>at its option repay the amounts outstanding under the Investor Notes before the maturity date, in whole or in part, at a price equal to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">100%</div> of the amount being repaid plus accrued and unpaid interest on such amount to the date of repayment.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In connection with the entry into the Investor Credit Agreements, on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 10, 2019, </div>the Company issued to the Investors warrants to purchase up to an aggregate of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,205,128</div> shares of Common Stock at an exercise price of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.90</div> per share, with an exercise term of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">two</div> years from issuance in a private placement pursuant to the exemption from registration under Section <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4</div>(a)(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2</div>) of the Securities Act and Regulation D promulgated under the Securities Act. The exercise price of the warrants is subject to standard adjustments but does <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> contain any anti-dilution protection, and the warrants only permit &#x201c;cashless&#x201d; or &#x201c;net&#x201d; exercise after the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">six</div>-month anniversary of issuance of the applicable warrant, and only to the extent that there is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> Investor <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>exercise its warrant to the extent that, after giving effect to such exercise, such Investor, together with its affiliates, would beneficially own in excess of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9.99%</div> of the number of shares of common stock outstanding after giving effect to such exercise. In addition, the Company agreed to file a registration statement providing for the resale by the Investors of the shares of Common Stock underlying the warrants with the SEC within <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">60</div> days following the date of the issuance of the warrants and to use commercially reasonable efforts to (i) cause such registration statement to become effective within <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">120</div> days following the date of the issuance of the warrants and (ii) keep such registration statement effective until the Investors <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> longer beneficially own any such shares of Common Stock or such shares of Common Stock are eligible for resale under Rule <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">144</div> under the Securities Act without regard to volume limitations. If the Company fails to file the registration statement by the filing deadline or the registration statement is <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> declared effective by the effectiveness deadline, or the Company fails to maintain the effectiveness of the registration statement as required by the warrants, then the exercise price of the warrants will be reduced by <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10%,</div> and by an additional <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5%</div> if such failure continues for longer than <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">90</div> days, subject to an exercise price floor of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.31</div> per share, provided that upon the cure by the Company of such failure, the exercise price of the warrants will revert to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.90</div> per share.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">In connection with the entry into the Investor Credit Agreements and the issuance of the warrants, on <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 10, 2019, </div>the Company and the Investors entered into a Standstill Agreement (the &#x201c;Investor Standstill Agreement&#x201d;), pursuant to which the Investors agreed that, until the earliest to occur of (i) the Investors <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">no</div> longer beneficially owning any shares underlying the warrants, (ii) the Company entering into a definitive agreement involving the direct or indirect acquisition of all or a majority of the Company&#x2019;s equity securities or all or substantially all of the Company&#x2019;s assets or (iii) a person or group, with the prior approval of the&nbsp;Company&#x2019;s Board of Directors (the &#x201c;Board&#x201d;), commencing a tender offer for all or a majority of the Company's equity securities,&nbsp;neither the Investors nor any of their respective affiliates will (without the prior written consent of the Board), among other things, (i) acquire any&nbsp;loans, debt securities, equity securities, or assets of the Company or any of its subsidiaries, or rights or options with respect thereto, except that the Investors shall be permitted to (a) purchase the shares underlying the warrants pursuant to the exercise of the warrants and (b)&nbsp;acquire beneficial ownership of up to <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6.99%</div> of the Common Stock,&nbsp;or (ii) make any proposal, public announcement, solicitation or offer with respect to, or otherwise solicit, seek or offer to effect, or instigate, encourage, or assist any <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">third</div> party with respect to: (a) any business combination, merger, tender offer, exchange offer, or similar transaction involving the Company or any of its subsidiaries; (b) any restructuring, recapitalization, liquidation, or similar transaction involving the Company or any of its subsidiaries; (c) any acquisition of any of the Company&#x2019;s loans, debt securities, equity securities or assets, or rights or options with respect thereto; or (d) any proposal to seek representation on the Board or otherwise seek to control or influence the management, Board, or policies of the Company, in each case subject to certain exceptions.</div></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; text-decoration: underline"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Balance at Beginning <br /> of Year</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Additions</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Reductions / <br /> Charges</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Balance at <br /> End of Year</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Deferred tax assets valuation allowance:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 44%">Year Ended December 31, 2018</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">81,086</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">42,939</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 11%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">124,025</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Year Ended December 31, 2017 (As Restated, Note 2)</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">386,867</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(305,781</div></td> <td style="white-space: nowrap; text-align: left">)</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">81,086</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> </table></div> <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3.</div> Balance Sheet Details</div></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Allowance for Doubtful Accounts</div></div>&nbsp;</div> <div style=" font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-indent: 27pt; margin: 0pt 0">Allowance for doubtful accounts activity and balances were as follows:</div> <div style=" font-size: 10pt; text-indent: 27pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; text-decoration: underline"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Balance at <br /> Beginning of Year</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Provisions</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Recoveries <br /> (Write-offs), Net</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Balance at <br /> End of Year</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Allowance for doubtful accounts:</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 48%">Year Ended December 31, 2018</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">642</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2013;</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right">&#x2013;</td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">642</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Year Ended December 31, 2017 (as restated, Note 2)</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">501</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">141</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right">&#x2013;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">642</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 12pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">&nbsp;</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Inventories</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold">December 31,<br /> (In thousands)</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="text-align: center"><div style="display: inline; font-weight: bold;">(As Restated, Note 2)</div></td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 66%; text-align: left">Raw materials</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,901</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">819</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Work in process</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">539</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">364</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Finished goods</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,253</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,225</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Total inventories</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,693</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,408</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt"></div> <div style=" font-size: 10pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Prepaid expenses and other current assets</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold">December 31,<br /> (In thousands)</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="text-align: center"><div style="display: inline; font-weight: bold;">(As Restated, Note 2)</div></td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 66%; text-align: left">Prepayments, advances and deposits</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,644</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,599</div></td> <td style="white-space: nowrap; width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Recoverable taxes from Brazilian government entities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">631</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">87</div></td> <td style="white-space: nowrap; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Other</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,291</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,233</div></td> <td style="white-space: nowrap; border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Total prepaid expenses and other current assets</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,566</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,919</div></td> <td style="white-space: nowrap; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Property, plant and equipment, net</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-size: 10pt; font-weight: bold">December 31,<br /> (In thousands)</td> <td style="font-size: 10pt; font-weight: bold">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td colspan="3" style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; font-weight: bold">&nbsp;</td> <td colspan="3" style="font-size: 10pt; font-weight: bold; text-align: center">(As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 66%; font-size: 10pt; text-align: left">Machinery and equipment</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 14%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">43,713</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> <td style="width: 1%; font-size: 10pt">&nbsp;</td> <td style="width: 1%; font-size: 10pt; text-align: left">$</td> <td style="width: 14%; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">46,317</div></td> <td style="width: 1%; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Leasehold improvements</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">39,922</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">40,036</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Computers and software</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,987</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,555</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left">Furniture and office equipment, vehicles and land</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,016</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,415</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Construction in progress</td> <td style="font-size: 10pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,749</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,838</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; text-indent: 10pt">Total property, plant and equipment, gross</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">98,387</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt">&nbsp;</td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">102,161</div></td> <td style="font-size: 10pt; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="font-size: 10pt; text-align: left">Less: accumulated depreciation and amortization</td> <td style="font-size: 10pt">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(78,631</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> <td style="font-size: 10pt; border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">(88,269</div></td> <td style="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">)</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="font-size: 10pt; text-align: left; text-indent: 10pt">Total property, plant and equipment, net</td> <td style="font-size: 10pt">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">19,756</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> <td style="font-size: 10pt; border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,892</div></td> <td style="border-bottom: Black 2.5pt double; font-size: 10pt; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0">Property, plant and equipment, net includes <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$5.0</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.2</div> million of machinery and equipment under capital leases as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> respectively. Accumulated amortization of assets under capital lease totaled <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$2.3</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1.6</div> million as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> respectively.</div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0">Depreciation and amortization expense, including amortization of assets under capital leases, was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$4.9</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$11.4</div> million for the years ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> respectively.</div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0">Losses on disposal of property, plant and equipment were <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.9</div> million and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.1</div> million for the years ended <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December&nbsp;</div><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">31,</div> <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2018</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017,</div> respectively. Such losses or gains were included in "Research and development" expense in the consolidated statements of operations.</div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2017, </div>the Company's sold its Brotas production plant in Brazil to a unit of DSM Nutritional Products Ltd (together with its affiliates, DSM); see Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">13,</div> "Divestiture" and Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">11,</div> "Related Party Transactions" for details.</div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Other assets</div></div></div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;"></div></div></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold">December 31,<br /> (In thousands)</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center">(As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 66%; text-align: left">Contingent consideration</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,286</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,150</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Deposits</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,465</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,462</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Other</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,207</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,947</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-left: 10pt">Total other assets</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,958</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">12,559</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-indent: 22.5pt; margin: 0pt 0"></div> <!-- Field: /Page --> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div style=" font-size: 10pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Accrued and other current liabilities</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold">December 31,<br /> (In thousands)</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td>&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td style="text-align: right">&nbsp;</td> <td>&nbsp;</td> <td colspan="3" style="text-align: center"><div style="display: inline; font-weight: bold;">(As Restated, Note 2)</div></td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Payroll and related expenses</td> <td>&nbsp;</td> <td style="text-align: right">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">9,220</div></td> <td style="text-align: right">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: right">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,238</div></td> <td style="text-align: right">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 66%; text-align: left">Contract termination fees</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">4,092</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Accrued interest</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,853</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">8,213</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Asset retirement obligation<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(1)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,063</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,587</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Ginkgo partnership payments obligation</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,155</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Tax-related liabilities</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,139</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">5,837</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Professional services</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,173</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,694</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td>Other</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">3,284</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,633</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; text-indent: 10pt">Total accrued and other current liabilities</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">28,979</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">29,202</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; margin: 0pt 0">______________</div> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; min-width: 700px;"> <tr style="vertical-align: top"> <td style="width: 0">&nbsp;</td> <td style="width: 0.25in"><div style="display: inline; font-size: 10pt"><div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div>)</div></div></td> <td><div style="display: inline; font-size: 10pt">The asset retirement obligation represents liabilities incurred but <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> yet discharged in connection with our <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2013</div> abandonment of a partially constructed facility in Prad&oacute;polis, Brazil.</div></td> </tr> </table> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"><div style="display: inline; font-weight: bold;">&nbsp;</div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;">Other noncurrent liabilities</div></div></div> <div style=" font-size: 10pt; text-align: justify; text-indent: 24pt; margin: 0pt 0"><div style="display: inline; font-weight: bold;"><div style="display: inline; font-style: italic;"></div></div></div> <div style=" margin-top: 0pt; margin-bottom: 0pt">&nbsp;</div> <div> <table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="font-weight: bold">December 31,<br /> (In thousands)</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2018</td> <td style="font-weight: bold; border-bottom: Black 1pt solid">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2017</td> </tr> <tr style="vertical-align: bottom"> <td>&nbsp;</td> <td>&nbsp;</td> <td colspan="3">&nbsp;</td> <td style="font-weight: bold">&nbsp;</td> <td colspan="3" style="font-weight: bold; text-align: center">(As Restated, Note 2)</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 66%; text-align: left">Liability for unrecognized tax benefit</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,582</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> <td style="width: 1%">&nbsp;</td> <td style="width: 1%; text-align: left">$</td> <td style="width: 14%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,582</div></td> <td style="width: 1%; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Deferred rent, net of current portion</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,440</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">7,818</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Ginkgo partnership payments obligation, net of current portion</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,185</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">6,444</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Contract liabilities, net of current portion</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,587</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">383</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Contract termination fees, net of current portion<div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(1)</div></td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1,530</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">&#x2014;</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Capital leases, net of current portion</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">195</div></td> <td style="text-align: left">&nbsp;</td> <td>&nbsp;</td> <td style="text-align: left">&nbsp;</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">217</div></td> <td style="text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Other</td> <td>&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">673</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> <td style="border-bottom: Black 1pt solid; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2,214</div></td> <td style="border-bottom: Black 1pt solid; text-align: left">&nbsp;</td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; text-indent: 10pt">Total other noncurrent liabilities</td> <td>&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,192</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> <td style="border-bottom: Black 2.5pt double">&nbsp;</td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td> <td style="border-bottom: Black 2.5pt double; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">23,658</div></td> <td style="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</td> </tr> </table> </div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">______________</div> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; min-width: 700px;"> <tr style="vertical-align: top"> <td style="width: 0">&nbsp;</td> <td style="width: 0.25in"><div style="display: inline; font-size: 10pt"><div style="display: inline; bottom:.33em; font-size: 82%; position: relative; vertical-align: baseline;">(<div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">1</div>)</div></div></td> <td><div style="display: inline; font-size: 10pt">Contract liabilities, net of current portion at <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018 </div>and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">2017</div> includes <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$1,204</div> and <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$383</div> in connection with DSM, which is a related party.</div></td> </tr> </table> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0"><div style="display: inline; font-weight: bold;"></div></div> <div style=" font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> November 2017, </div>the Company entered into a partnership agreement with <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">one</div> of its former collaboration partners, Ginkgo Bioworks, Inc. and has an obligation to make quarterly payments of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$0.8</div> million from <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018 </div>through <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 2022. </div>At <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018, </div>total future minimum payments under the agreement totaled <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$12.7</div> million. The Company recorded this liability at its discounted present value of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.1</div> million and is accreting the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$6.6</div> million discount to interest expense over the <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">five</div>-year repayment period. Also, in conjunction with the partnership agreement, the Company issued a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$12.0</div> million promissory note, which is included in long-term debt at a <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$8.0</div> million carrying value, net of unamortized discount. See Note <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">10,</div> &#x201c;Revenue Recognition&#x201d; for information regarding the Ginkgo Partnership Agreement and the related accounting treatment for the partnership payments.</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">&nbsp;</div> <div style=" font-size: 10pt; text-align: justify; text-indent: 23pt; margin: 0pt 0">In <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> September 2019, </div>the Company was notified by DSM that certain contingent consideration payable to the Company upon the realization of certain NOL tax benefits transferred to DSM with the sale of the Brotas facility in <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 2017 </div>would <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> be realized due to changes in DSM&#x2019;s Brazilian legal entity structure. The Company considered this information in conjunction with the probability and timing of DSM&#x2019;s realization of the underlying NOL tax benefits and determined that <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">$3.9</div> million of the contingent consideration receivable was <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">not</div> recoverable as of <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> December 31, 2018.</div></div></div> 1600000 13500000 2139000 5837000 5000000 5000000 5000000 1600000 -13991000 -40159000 -40159000 -30880000 -48852000 -1742000 -47110000 9101000 28833000 30127000 0 0 19682000 1239000 50000 55000 <div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style="display: inline; font-family: times new roman; font-size: 10pt"><div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt"><div style="display: inline; font-weight: bold;">Use of Estimates and Judgements</div></div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">&nbsp;</div> <div style=" font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24pt">The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates, judgements and assumptions that affect the reported amounts of assets and liabilities, disclosures of contingent assets and liabilities at the date of the financial statements, and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates, and such differences <div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;"> may </div>be material to the consolidated financial statements.</div></div></div></div></div></div></div></div></div></div></div></div> 305800000 42900000 24100000 10600000 13000000 12000000 25000000 5600000 10600000 P2Y P2Y P2Y P2Y P2Y P2Y 60405910 32253570 32253570 Less than 10% Less than 10% The asset retirement obligation represents liabilities incurred but not yet discharged in connection with our 2013 abandonment of a partially constructed facility in Prad&#243;polis, Brazil. Excluding net debt discount of $17.1 million that will be amortized to interest expense over the term of the debt. The balance in contract liabilities, current at December 31, 2017 represents deferred revenue, current prior to the Company's adoption of ASC 606, "Revenue". The balances in contract liabilities, noncurrent are included in other noncurrent liabilities on the consolidated balance sheets. Contract liabilities, net of current portion at December 31, 2018 and 2017 includes $1,204 and $383 in connection with DSM, which is a related party. The potentially dilutive effect of convertible promissory notes was computed based on conversion ratios in effect at the respective year-end. A portion of the convertible promissory notes issued carries a provision for a reduction in conversion price under certain circumstances, which could potentially increase the dilutive shares outstanding. Another portion of the convertible promissory notes issued carries a provision for an increase in the conversion rate under certain circumstances, which could also potentially increase the dilutive shares outstanding. The balance in contract liabilities at December 31, 2017 represents deferred revenue, current prior to the Company's adoption of ASC 606, "Revenue". Licenses and royalties revenues is negative for 2017 due to the $13.1 million reversal of cumulative inception to date revenue as a result of entering into the 2017 Ginkgo Partnership Agreement. See Note 10. Revenue Recognition. Reclassification of revenue and operating expense by type to conform to the Company's current presentation. Reclassification of related party accounts receivable to a separate line on the balance sheet. Ginkgo partnership obligation and promissory note issuance recorded as reduction to revenue and correction of errors in recording revenue from non-cash consideration. Correction in connection with a sales return, and adjustment to uninvoiced receipts liability. Write-off of unrecoverable receivable in connection with facilities subleased to a related party, and reclassification of operating expense by classification to conform to the Company's current presentation. Expense incurred in connection with May 2017 equity offering. Correction to amortization of debt discounts, and interest expense in connection with partnership payments obligation. Correction to accounting for make-whole liability in connection with May 2017 Offering. Loss on extinguishment of related and unrelated party debt. Tax provision to accrue liability for unrecognized tax benefit. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings. Correction in the computation of loss per share to reflect participating securities. Correction in the computation of net loss per share related to make-whole deemed dividends. Write-off of unrecoverable receivable in connection with facilities subleased to a related party. Correction of error in recording amounts payable under Ginkgo Partnership Agreement as prepaid royalties instead of reduction in revenue. Adjustment to uninvoiced receipts liability. Adjustment to accrued liability. Revision to accounting for equity received in satisfaction of a customer receivable. Adjustment to issuance-date fair value of a debt instrument. Make-whole derivative liabilities adjustment. Accrual of the Ginkgo Partnership Payments obligation, net of reduction to deferred revenue liability. Correction to the accounting for a make-whole equity instrument in connection with May 2017 equity offering. 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[Member] Represents information pertaining to Nenter & Co., Inc. us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1 Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition amrs_DebtInstrumentEarlyRepaymentAmountPercentage Debt Instrument, Early Repayment Amount, Percentage The percentage of the price that can be paid early on debt. 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Adjustments for Error Correction [Domain] Award Type [Domain] amrs_ReturnRequiredForCollaborationPartnerBeforeAdjustingSplitOnSalesMargin Return Required for Collaboration Partner Before Adjusting Split on Sales Margin Represents the amount of return the collaborator must realize before an adjustment to the sales margin revenue will take place. amrs_SuccessBonus Success Bonus Represents the amount of money the company will pay to the partner if certain performance milestones are met. amrs_SalesMarginCompanyPercentageSplitFollowingReturnRequirements Sales Margin Company Percentage Split Following Return Requirements Represents the percentage of the sales margin that will go to the company after the return requirements as specified in the contract have been met. 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Related Party 2014 144A Convertible Notes [Member] Represents information pertaining to the 2014 144A Notes, which are related-party convertible notes. us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest Comprehensive loss attributable to Amyris, Inc. Measurement Input, Probability of Change in Control [Member] Measurement input using probability of change in control. Second Aprinnova Loan [Member] Represents information pertaining to a second loan to Aprinnova. Embedded Derivative Financial Instruments [Member] Measurement Input, Risk-adjusted Yields [Member] Measurement input using risk-adjusted yields. The February 2016 Warrants [Member] Represents information pertaining to the February 2016 warrants, issued in relation to the February 2016 Related Party Private Placement. amrs_DesignatedDirectorMinimumBeneficialOwnershipLevel Designated Director, Minimum Beneficial Ownership Level Represents the minimum beneficial ownership level of a designated director, with regard to a specified agreement. Nonrelated Party Debt [Member] Represents the information pertaining to nonrelated party debt. Derivative Instrument [Axis] Derivative Contract [Domain] Designated Director Two [Member] Represents information pertaining to a second designated director. Warrant 3 [Member] Represents the third group of the warrants. amrs_MinimumBeneficialOwnershipLevelToDesignateADirector Minimum Beneficial Ownership Level to Designate a Director Represents the minimum beneficial ownership level required to designate one director to the Board. Warrant 2 [Member] Represents the second group of the warrant. Warrant 1 [Member] Represents the first group of warrants. Designated Director One [Member] Represents information pertaining to a first designated director. amrs_ClassOfWarrantOrRightDilutionPeriod Class of Warrant or Right, Dilution Period Represents the period, from the date of issuance, over which the exercise price of a warrant or right is subject to standard adjustments as well as full-ratchet anti-dilution protection. Warrant 7 [Member] Represents the seventh group of the warrants. Warrant 6 [Member] Represents the sixth group of the warrants. Warrant 5 [Member] Represents the fifth group of the warrants. Warrant 4 [Member] Represents the fourth group of the warrants. Convertible Debt [Member] Letter of Credit [Member] amrs_ReceivableFromCollaborators Receivable from Collaborators Amount receivable from collaborators as of the balance sheet date. Ginkgo Bioworks, Inc. [Member] Represents the name of a buyer in an equity transaction. amrs_CollaborationAgreementPeriod Collaboration Agreement Period Represents term of collaboration agreement. amrs_RoyaltyPercentage Royalty Percentage The percent of net revenue to be paid as royalties to the Company quarterly. Loans Payable [Member] us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments Loss before income taxes Loss before income taxes us-gaap_IncomeTaxExpenseBenefit Provision for income taxes Total provision for income taxes$ Provision for income taxes Secured R&D Notes [Member] Represents information pertaining to secured R&D Notes. amrs_IncreaseDecreaseInRestrictedCashContingentlyRedeemableEquity Change in restricted cash related to contingently redeemable common stock The change in cash due to the issuance of contingently redeemable equity. (Loss) gain on divestiture Disposal Group, Not Discontinued Operation, Gain (Loss) on Disposal Loss (gain) on divestiture Non-cash gain on divestiture Loss from change in fair value of derivative instruments Gain (Loss) on Derivative Instruments, Net, Pretax, Total Derecognition of derivative liabilities upon exercise of warrants Represents the amount of the settlement of derivative liability into equity during the period. Restricted cash, noncurrent Restricted cash, noncurrent Restricted Cash and Cash Equivalents, Noncurrent, Total Restricted cash, noncurrent Restricted cash Restricted cash Restricted cash, current us-gaap_LeaseAndRentalExpense Operating Leases, Rent Expense, Total Cash and cash equivalents Cash and cash equivalents Cash and cash equivalents Royalty [Member] Derivative Liability, Debt-related [Member] Represents information relating to debt-related derivative liabilities. 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Customer B [Member] Represents information pertaining to Customer B. Customer F [Member] Represents information pertaining to Customer F. us-gaap_DisclosureTextBlockAbstract Notes to Financial Statements Noncontrolling Interest [Policy Text Block] Disclosure of accounting policy for noncontrolling interest. Customer A [Member] Represents information pertaining to Customer A. Subsequent Event [Member] Schedule of Inventory, Current [Table Text Block] Customer D [Member] Represents information pertaining to Customer D. Subsequent Event Type [Axis] Subsequent Event Type [Domain] Subsequent Events [Text Block] Deposits The $5 Million Note [Member] Represents the Amended and Restated Note that are issued and sold by the company under the April 2017 Purchase Agreement. us-gaap_UnamortizedDebtIssuanceExpense Unamortized Debt Issuance Expense Fair Value Measurement, Policy [Policy Text Block] Accounts receivable, unbilled, noncurrent – related party Accounts receivable, unbilled, noncurrent - related party Foreign Currency Transactions and Translations Policy [Policy Text Block] Other assets Other assets Total other assets Secured Promissory Note In Connection With Termination of Ginkgo Collaboration Agreement [Member] Represents the secured promissory note that issued and sold in connection with the termination of Ginkgo Collaboration Agreement. amrs_EarlyPaymentDiscount Early Payment Discount Represents the amount of early payment discount that reduces the revenue recognized. amrs_ChargeRelatedToFinalWorkingCapitalAdjustmentsBetweenTheCompanyAndACounterparty Charge Related to Final Working Capital Adjustments Between the Company and a Counterparty Represents the amount of the charge during the period related to the final working capital adjustments between the reporting entity and a counterparty. DSM Credit Agreement [Member] Represents the information pertaining to DSM Credit Agreement. Revenues us-gaap_Revenues Revenues, Total Deferred cost of products sold, noncurrent - related party amrs_MaximumDarpaFundingToBeReceivedIfAllMilestonesAreAchieved Maximum DARPA Funding to be Received if all Milestones are Achieved The maximum amount of funding that can be collectively received from DARPA by the company and its subcontractors if all of the program's milestones are achieved. Income Tax, Policy [Policy Text Block] Allowance for Doubtful Accounts Activity and Balances [Table Text Block] Tabular disclosure of doubtful accounts activity and balances. DSM Note [Member] Represents the information pertaining to DSM note. Probability of Principal Repayment in Cash [Member] Represents information pertaining to the probability of principal repayment in cash. Technology Investment Agreement with DARPA [Member] Represents the technology investment agreement with DARPA. amrs_RecoverableTaxesFromBrazilianGovernmentEntities Recoverable taxes from Brazilian government entities Represents the amount of recoverable taxes from Brazilian government entities. amrs_CollectiveObligationDue Collective Obligation Due The amount the company and its subcontracts are collectively obligated to contribute toward the program. Research and Development Expense, Policy [Policy Text Block] Probability of Principal Repayment in Stock [Member] Represents information pertaining to the probability of principal repayment in stock. Partnership Agreement [Member] Represents the information pertaining to partnership agreement. amrs_PartnershipAgreementQuarterlyFees Partnership Payments, Quarterly Fees The amount of quarterly fees to be paid to counter party pursuant to the partnership agreement. Renewable Products [Member] Represents the information pertaining to Renewable Products. Licenses and Royalties [Member] Represents the information pertaining to licenses and royalties. amrs_CollaborationAgreementAutomaticRenewalTerm Collaboration Agreement, Automatic Renewal Term Automatic renewal term for collaboration agreement. Revenue in Connection with Significant Revenue Agreement [Table Text Block] Tabular disclosure of revenue in connection with significant revenue agreement. All Other Customers [Member] Represents all other customers that are not in connection with the significant revenue agreements. us-gaap_SharesIssuedPricePerShare Shares Issued, Price Per Share Grants and Collaborations [Member] Represents the information pertaining to grants and collaborations. Schedule of Related Party Debt [Table Text Block] Tabular disclosure of information pertaining to related party debt. Total current assets us-gaap_AssetsCurrent Total current assets Related Party Debt [Member] Represents the information pertaining to related party debt. Significant Revenue Agreement [Member] Represent the information pertaining to the significant revenue agreement. Stockholders' Equity Note Disclosure [Text Block] Naxyris S.A. [Member] Represents Naxyris S.A. amrs_DebtInstrumentProceedsUsedToRepayLiabilities Debt Instrument, Proceeds Used to Repay Liabilities Represents information pertaining to proceeds from a debt instrument used to repay liabilities. Compensation Related Costs, Policy [Policy Text Block] amrs_ClassOfWarrantOrRightExercisesDuringThePeriod Class of Warrant or Right, Exercises During the Period Represents the number of warrants or rights exercised during the period. amrs_PartnershipPaymentsExpectedToBeMade Partnership Payments Expected to Be Made Represents the amount of partnership payments anticipated in the future, as of the specified date. Schedule of Related Party Accounts Receivables [Table Text Block] Tabular disclosure of related party accounts receivables. Period-end Preferred Shares [Member] Represents information pertaining to period-end preferred shares. Contract Assets - Related Party and Contract Assets, Noncurrent - Related Party [Member] Represents information included in the balance sheet line items Contract Assets - Related Party and Contract Assets, Noncurrent - Related Party. us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount Customers Other Than Related Parties [Member] Represents all customers other than related parties. Schedule of Related Party Revenues [Table Text Block] Tabular disclosure of related party revenues. 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Summary of Valuation Allowance [Table Text Block] amrs_AutomaticAnnualIncreaseInTheNumberOfSharesAvailableForGrantAndIssuance Automatic Annual Increase in the Number of Shares Available for Grant and Issuance Represents the automatic annual increase in the number of shares available for grant and issuance. amrs_PerformancebasedStockOptionsGrantDateFairValue Performance-based Stock Options, Grant Date Fair Value The amount of fair value at grant date for performance-based stock options. us-gaap_OtherAssetsCurrent Other amrs_DebtInstrumentFundedAmountAndOtherClosingCosts Debt Instrument, Funded Amount and Other Closing Costs Amount of funds and other closing costs associated with the borrowing of money under the debt instrument. amrs_DebtInstrumentAgencyFeeAmountPerQuarter Debt Instrument, Agency Fee Amount Per Quarter Amount of agency fees that accompanies borrowing money under the debt instrument per quarter. amrs_AutomaticAnnualIncreaseInSharesReservedForIssuancePercentageOfOutstandingStock Automatic Annual Increase in Shares Reserved for Issuance, Percentage of Outstanding Stock Represents the automatic annual increase in shares reserved for issuance, expressed as a percentage of the outstanding stock as of the end of the most recent fiscal year. Debt, Policy [Policy Text Block] Performance-based Stock Options [Member] Represents the information pertaining to performance-based stock options. Accounts receivable, unbilled - related party Accounts receivable, unbilled - related party us-gaap_DeferredTaxAssetsLiabilitiesNet Net deferred tax assets us-gaap_PrepaidExpenseCurrent Prepayments, advances and deposits Long-Lived Assets Intangible and others us-gaap_DeferredTaxAssetsOther Impairment or Disposal of Long-Lived Assets, Including Intangible Assets, Policy [Policy Text Block] amrs_PostClosingWorkingCapitalAdjustmentPaymentRecordedAsLossOnDivestiture Post-closing Working Capital Adjustment Payment Recorded as Loss on Divestiture Represents the amount of post-closing working capital adjustment payment recorded as loss on divestiture during the period. us-gaap_DeferredTaxAssetsGross Total deferred tax assets us-gaap_DeferredIncomeTaxLiabilities Total deferred tax liabilities Inventories Inventories Total inventories Gain from change in fair value of debt Debt, Changes in Fair Value, Gain (Loss) Gain from change in fair value of debt The amount of gain loss recognized due to changes in debt fair value. 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Lavvan [Member] Represents information pertaining to Lavvan, Inc. amrs_CommonStockIssuedDuringPeriodSharesConversionOfDebt Issuance of common stock upon conversion of debt (in shares) Number of common shares issued during the period as a result of the conversion of debt. amrs_AdjustmentsToAdditionalPaidInCapitalDeemedDividends Deemed dividend Amount of increase in additional paid in capital (APIC) resulting from dividends being declared. us-gaap_PropertyPlantAndEquipmentUsefulLife Property, Plant and Equipment, Useful Life The Cannabinoid Agreement [Member] Represents information pertaining to a research, collaboration and license agreement for the development, manufacture and commercialization of cannabinoids. Convertible Notes [Member] Related to all convertible notes. Issuance of common stock upon conversion of preferred stock (in shares) Number of common shares issued during the period as a result of the conversion of preferred stock. amrs_DebtInstrumentCovenantTermsMinimumCashAmountRedeemedPercentageUponDefault Debt Instrument, Covenant Terms, Minimum Cash Amount Redeemed Percentage Upon Default The minimum percentage of cash amount that can be redeemed in certain events of default. Issuance of common stock for settlement of debt The fair value of stock issued for settlement of debt principal payments in noncash financing activities. Construction in Progress [Member] amrs_DebtInstrumentPeriodicPaymentCashPercentageOfEachInstallmentAmount Debt Instrument, Periodic Payment, Cash Percentage of Each Installment Amount The percentage of periodic cash payments for each installment amount. 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Issuance of common stock for settlement of debt principal payments (in shares) Number of common shares issued during the period as a result of the settlement of debt principal payments. amrs_AgreementAmountOfResearchAndDevelopmentFundingThatCouldBeReceived Agreement, Amount of Research and Development Funding that Could Be Received Represents the amount of research and development funding that could by received by the reporting entity under an agreement, if all milestones are achieved. Issuance of common stock for settlement of debt interest payments (in shares) Number of common shares issued during the period as a result of the settlement of debt interest payments. Issuance costs amrs_AdjustmentsToAdditionalPaidInCapitalStockIssuedUponConversionOfDebtIssuanceCosts Amount of decrease in additional paid in capital (APIC) resulting from direct costs associated with issuing stock upon the conversion of debt. 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Cumulative effect adjustment of ASC 606 The amount of cumulative effect adjustment due to a new accounting policy. Issuance of common stock - related party The amount of cash inflow from common stock private placement issuance to related party. June Foris Credit Agreement [Member] Information pertaining to the June Foris Credit Agreement, entered into on June 11, 2019. April Foris Credit Agreement [Member] Information pertaining to the April Foris Credit Agreement, entered into on April 8, 2019. Loan and Security Agreement Amendment and Waiver [Member] Represents information pertaining to the Loan and Security Agreement Amendment and Waiver. amrs_ContractualObligationPresentValue Contractual Obligation, Present Value The present value amount of a contractual obligation. amrs_PartnershipAgreementQuarterlyPaymentAmount Partnership Agreement, Quarterly Payment Amount The amount of quarterly payments made under the partnership agreement. us-gaap_DeferredTaxLiabilitiesDerivatives Debt discount and derivatives July Foris Credit Agreement [Member] Information pertaining to the July Foris Credit Agreement, entered into on July 10, 2019. Promissory Note for Partnership Agreement With Ginkgo Bioworks [Member] Related to the promissory note. us-gaap_PaymentsOfStockIssuanceCosts Payments of Stock Issuance Costs Issuance costs incurred Concentration Risk, Credit Risk, Policy [Policy Text Block] Partnership Agreement with Ginkgo Bioworks Inc. [Member] Related to the partnership agreement with Ginkgo Bioworks Inc. amrs_ContractualObligationTerm Contractual Obligation, Term The length of a contractual obligation term. us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation Payment of minimum employee taxes withheld upon net share settlement of restricted stock units Payment of minimum employee taxes withheld upon net share settlement of restricted stock units Net amrs_LongtermDebtExcludingCurrentMaturitiesIncludingDueToRelatedParties Amount after unamortized (discount) premium and debt issuance costs of long-term debt classified as noncurrent, including due to related parties and excluding amounts to be repaid within one year or the normal operating cycle, if longer. Includes, but not limited to, notes payable, bonds payable, debentures, mortgage loans and commercial paper. Excludes capital lease obligations. amrs_LongtermDebtCurrentMaturitiesIncludingDueToRelatedParties Long-term Debt, Current Maturities, Including Due to Related Parties Net Amount, after unamortized (discount) premium and debt issuance costs, of long-term debt, classified as current including due to related parties. Includes, but not limited to, notes payable, bonds payable, debentures, mortgage loans and commercial paper. Excludes capital lease obligations. amrs_ContractualObligationInterestPayable Contractual Obligation, Interest Payable The amount of interest payable in a contractual obligation. Ginkgo partnership payments obligation The amount of partnership payments obligation classified as current. Contract termination fees The amount of contract termination fees payable classified as current. Realization of Certain NOL Tax Benefits [Member] Related to the realization of certain NOL tax benefits. amrs_ContingentConsiderationReceivable Contingent Consideration Receivable The amount of contingent consideration receivable. amrs_PreferredStockBeneficialOwnershipLimitation Preferred Stock, Beneficial Ownership Limitation The percent of limitation on the beneficial ownership of preferred stock. us-gaap_PaymentsOfDebtExtinguishmentCosts Payment on early redemption of debt Payment on early redemption of debt amrs_SupplyAgreementWarrantModificationAmount Supply Agreement, Warrant Modification Amount The amount of warrant modification amount in the supply agreement. amrs_AgreementAcceleratedPaymentFee Agreement, Accelerated Payment Fee The fee associated with accelerating the payment of a certain agreement. DSM Supply Agreement [Member] Related to the DSM supply agreement. Contract termination fees, net of current portion(1) The amount of contract termination fees classified as noncurrent. Ginkgo partnership payments obligation, net of current portion The amount of partnership payments obligation classified as noncurrent. Discount to Gross Cash Flows [Member] Related to the discount on gross cash flows. amrs_SupplyAgreementMeasurementInput Supply Agreement, Measurement Input Value of input used to measure the supply agreement. amrs_SupplyAgreementFairValueConsideration Supply Agreement, Fair Value Consideration Total fair value of consideration transferred The amount of fair value consideration under the supply agreement. amrs_SupplyAgreementPaymentsForObligationSettlements Supply Agreement, Payments for Obligation Settlements The amount of payments for obligation settlements in certain supply agreements. Manufacturing capacity reservation fee The amount of manufacturing capacity reservation fee in a certain supply agreement. Legal settlement and consent waiver The amount of legal settlement and consent waiver in a certain supply agreement. Working capital adjustment The amount of working capital adjustment from a supply agreement. Fair Value of Consideration [Table Text Block] Tabular disclosure for the fair value of a consideration. August Foris Credit Agreement [Member] Information pertaining to the August Foris Credit Agreement entered into on August 28, 2019. us-gaap_CostsAndExpenses Total cost and operating expenses Total cost and operating expenses Foris Credit Agreements [Member] Information pertaining to the Foris Credit Agreements which is comprised of the April, June, and July Foris credit agreements. Schedule of Related Party Assets and Liabilities [Table Text Block] The tabular disclosure for assets and liabilities of related party. DSM November 2018 Letter Agreement [Member] Represents the DSM November 2018 letter agreement. us-gaap_ProceedsFromIssuanceOrSaleOfEquity Proceeds from Issuance or Sale of Equity, Total amrs_ContractWithCustomerLiabilityFairValueAdjustment Contract with Customer, Liability, Fair Value Adjustment The difference between actual amount of contract with customer liability and the fair value of the elements. amrs_ClassOfWarrantOrRightStockOwnershipPercentageRestrictionOnAbilityToExercise Class of Warrant or Right, Stock Ownership Percentage, Restriction on Ability to Exercise Represents a restriction on the exercise of warrants or rights in which the exercise of warrants or rights would result in beneficial ownership of an equal or greater percentage of a specified threshold of stock in the Company. First Aprinnova Loan [Member] Represents the first aprinnova loan. Cost and operating expenses Proceeds from ESPP purchases The amount of cash inflow from employee stock ownership plan purchases. Scenario [Domain] us-gaap_ProceedsFromIssuanceOfWarrants Proceeds from Issuance of Warrants Disallowed interest carryforward Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from disallowed interest carryforward. Proceeds from exercise of warrants, net of issuance costs Proceeds from Warrant Exercises Forecast [Member] amrs_OperatingLossCarryforwardsWriteoff Operating Loss Carryforwards, Write-off The amount of operating loss carryforwards written off. amrs_CommonStockValueReservedForFutureIssuance Common Stock, Value Reserved for Future Issuance Amount of common stock reserved for future issuance. us-gaap_ProceedsFromIssuanceOfConvertiblePreferredStock Proceeds from Issuance of Convertible Preferred Stock Issuance of common stock in private placement - related party, net of issuance costs of $0 The value of stock issued during the period to related parties. December 2017 Convertible Note [Member] Represents the information pertaining to December 2017 convertible note. Proceeds from issuance of common stock in private placements, net of issuance costs Proceeds from Issuance of Private Placement Other Non-affiliated Investors [Member] Represents certain other non-affiliated investors. Common Stock Issued upon Extinguishment of Tranche II Note [Member] Represents common stock issued upon extinguishment of tranche 2 note. Warrants in Connection of Extinguishment of Tranche II Note [Member] Represents warrants issued in connection with tranche 2 note extinguishment. Proceeds from exercises of common stock options Proceeds from exercises of common stock options Issuance of common stock for settlement of debt principal and interest payments The amount of stock issued for settlement of debt principal and interest payments. Private Placement, April 26, 2019 [Member] Represents the private placement which took place on April 26, 2019. The 2015 Exchange Agreement [Member] Represents the 2015 exchange agreement. Proceeds from issuance of common stock in August 2017 offering Proceeds from Issuance of Common Stock Title of Individual [Domain] State Issuance of common stock in private placement - related party, net of issuance costs of $0 (in shares) The number of shares issued during the period to related parties. Initial Application Period Cumulative Effect Transition [Axis] amrs_DebtInstrumentCovenantMaximumAmountOfDebt Debt Instrument, Covenant, Maximum Amount of Debt The maximum amount of debt allowed under debt instrument terms. Title of Individual [Axis] us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit State Initial Application Period Cumulative Effect Transition [Domain] Issuance costs amrs_AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCostsRelatedParties The amount of adjustments to additional paid in capital from stock issuance costs to related parties. Scenario [Axis] Private Placement, April 16, 2019 [Member] Represents the private placement which took place on April 16, 2019. Difference between Revenue Guidance in Effect before and after Topic 606 [Member] Common Stock Issued Upon Conversion of Convertible Notes [Member] Represents common stock issued upon conversion of convertible notes amrs_DebtInstrumentCovenenantMaximumAmountOfSecuredDebtToTotalAssets Debt Instrument, Covenenant, Maximum Amount of Secured Debt to Total Assets The percentage of maximum amount of secured debt to total assets allowed under debt instrument terms. Foreign amrs_DebtInstrumentCovenantMaximumAmountOfSecuredDebt Debt Instrument, Covenant, Maximum Amount of Secured Debt The maximum amount of secured debt allowed under debt instrument terms. us-gaap_DeferredForeignIncomeTaxExpenseBenefit Foreign amrs_DebtInstrumentCovenantMaximumAmountOfDebtPercentageOfTotalAssets Debt Instrument, Covenant, Maximum Amount of Debt Percentage of Total Assets The percentage of maximum amount of debt to total assets allowed under debt instrument terms. Private Placement May 3, 2019 [Member] Represents private placement on may 3, 2019. Private Placement April 29, 2019 [Member] Represents the private placement on April 29, 2019. Federal amrs_WarrantExerciseBeneficialCommonStockOwnershipMaximumPercentage Warrant Exercise, Beneficial Common Stock Ownership Maximum Percentage The maximum percentage of beneficial common stock ownership under warrant exercises. us-gaap_DeferredFederalIncomeTaxExpenseBenefit Federal LSA Amendment Warrants [Member] Represents warrants issued in connection with LSA Amendment. The 2019 DSM Credit Agreement, Second Installment [Member] Represents information pertaining to the second installment of the "2019 DSM Credit Agreement" entered into on September 17, 2019. Deferred: The 2019 DSM Credit Agreement, First Installment [Member] Represents information pertaining to the first installment of the "2019 DSM Credit Agreement" entered into on September 17, 2019. The 2019 DSM Credit Agreement [Member] Represents information pertaining to the "2019 DSM Credit Agreement" entered into on September 17, 2019. amrs_ConsiderationTransferredCashAmount Consideration Transferred, Cash Amount The amount of the cash portion of the consideration transferred in accordance to certain agreements. Raizen Energia S.A. [Member] Represents Raizen Energia S.A. (Raizen). Current: amrs_ProceedsFromSaleOfEquitySecuritiesGrossTriggerRepaymentOfAmountsOutstandingUnderLineOfCredit Proceeds from Sale of Equity Securities, Gross, Trigger Repayment of Amounts Outstanding Under Line of Credit The minimum amount of gross cash proceeds from one or more sales of equity securities which would trigger a required repayment of any amounts outstanding under a line of credit. amrs_DebtInstrumentRepaymentPricePercentOfFaceAmount Debt Instrument, Repayment Price, Percent of Face Amount The repayment price, as a percent of face value, of the debt instrument excluding any accrued and unpaid interest. The 2019 DSM Credit Agreement, Third Installment [Member] Represents information pertaining to the third installment of the "2019 DSM Credit Agreement" entered into on September 17, 2019. us-gaap_CurrentIncomeTaxExpenseBenefit Total current provision Maxwell (Mauritius) Pte Ltd [Member] Represents Maxwell (Mauritius) Pte Ltd. us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1 Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period Warrants Issued for 2014 Rule 144A Convertible Notes Exchanges [Member] Represents warrants issued for 2014 Rule 144A convertible notes exchanges. amrs_DebtConversionConvertedInstrumentWarrantsIssued Debt Conversion, Converted Instrument, Warrants Issued Represents the number of warrants issued in exchange for the original debt being converted in a noncash (or part noncash) transaction. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or payments in the period. us-gaap_RevenueRemainingPerformanceObligation Revenue, Remaining Performance Obligation, Amount amrs_CapitalContributionToTheJointVenture Capital Contribution to the Joint Venture The cash outflow associated with a capital contribution to a joint venture. Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis] Foreign us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign Warrants Issued in Exchange for 6% Convertible Notes Due 2021 [Member] Represents warrants issued in exchange for 6% convertible notes due 2021. Convertible Senior Notes, 10.5% [Member] Represents the 10.5% Convertible Senior Notes. Warrants Issued in Exchange for Convertible Senior Notes, 6.0% Due 2021, Second Exchange [Member] Represents warrants issued in exchange for 6.0% convertible senior notes due 2021 issued in the "Second Exchange" on July 24, 2019. Convertible Senior Notes, 6.0%, Due in 2021, Second Exchange [Member] Represents the 6.0% convertible senior notes due 2021 issued in the "Second Exchange" on July 24, 2019. us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest Loss before income taxes United States Nikko Loan Agreement, Second Installment [Member] Represents the second installment of the Nikko Loan Agreement. Nikko Loan Agreement, First Installment [Member] Represents the first installment of the Nikko Loan Agreement. Nikko Loan Agreement [Member] Information pertaining to the Nikko Loan Agreement. amrs_DebtInstrumentPenaltyForFailureToMakePaymentPremiumIncreasePercentage Debt Instrument, Penalty for Failure to Make Payment, Premium Increase Percentage Represents the percent increase in the face amount of the debt instrument as a result of a failure to make an installment payment. Fixed Assets From Sao Martinho S.A. [Member] Related to fixed assets from Sao Martinho S.A. Fixed Assets Owned by the Company [Member] Related to fixed assets owned by the company. amrs_FirstPriorityLienOnInterestsOwnedByTheCompany First Priority Lien on Interests Owned by the Company The percent of interest owned by the company in another entity which secure a first-priority lien. amrs_ProceedsFromIssuanceOfLongtermDebtWithheldAsPrepaymentOfInterestPayable Proceeds from Issuance of Long-term Debt, Withheld as Prepayment of Interest Payable Represents the amount of proceeds from an issuance of long-term debt which are being withheld as prepayment of interest payable. Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Table Text Block] The Investors [Member] Related to the investors. amrs_DebtInstrumentFailureToPayFee Debt Instrument, Failure to Pay Fee The percent of the failure to pay fee for a debt instrument. Interest Wtih Respect to Indebtedness [Member] Related to the interest with respect to indebtedness. The Naxyris Loan Agreement [Member] Related to the Naxyris Loan Agreement. amrs_WarrantsOrRightsOutstandingReductionInExercisePrice Warrants or Rights Outstanding, Reduction in Exercise Price The amount of reduction in exercise price of warrants or rights outstanding. amrs_WarrantsOrRightsOutstandingMaximumPercentOfCommonStockOutstanding Warrants or Rights Outstanding, Maximum Percent of Common Stock Outstanding The maximum percent of common stock outstanding allowed to be held by holders of the warrants or rights. Investor Warrants [Member] Related to investor warrants. Secretariat of the Federal Revenue Bureau of Brazil [Member] The Investor Notes [Member] Related to the investor notes. State and Local Jurisdiction [Member] Income Tax Authority, Name [Axis] amrs_AdjustmentsToAdditionalPaidInCapitalDeemedDividendsOnPreferredStockDiscountsUponConversionOfPreferredStockOffset Deemed dividend on preferred stock discounts upon conversion of preferred stock The amount of adjustment to additional paid in capital from deemed dividends on preferred stock discounts upon conversion of preferred stock. Performance Option and Transition Services Agreements [Member] Related to agreements. Income Tax Authority, Name [Domain] Internal Revenue Service (IRS) [Member] amrs_WarrantsOrRightsOutstandingAdditionalReductionInExercisePrice Warrants or Rights Outstanding, Additional Reduction in Exercise Price The percentage of additional reduction in exercise price for warrants or rights outstanding. Income Tax Authority [Axis] Income Tax Authority [Domain] Disaggregation of Revenue [Table Text Block] Domestic Tax Authority [Member] Deferred cost of products sold, current - related party The amount due from related parties for deferred cost of products sold. Foreign Tax Authority [Member] us-gaap_RepaymentsOfLongTermDebt Repayments of Long-term Debt, Total Principal payments on debt Principal payments on debt us-gaap_RepaymentsOfLongTermCapitalLeaseObligations Principal payments on capital leases amrs_DebtInstrumentFacilityChargePercentage Debt Instrument, Facility Charge, Percentage Represents the facility charge for the debt instrument. Cash and Cash Equivalents, Policy [Policy Text Block] us-gaap_UnrecognizedTaxBenefits Balance Balance Accounting Policies [Abstract] Significant Accounting Policies [Text Block] us-gaap_OpenTaxYear Open Tax Year Basis of Accounting, Policy [Policy Text Block] Schedules of Concentration of Risk, by Risk Factor [Table Text Block] us-gaap_CommonStockDividendsPerShareDeclared Common Stock, Dividends, Per Share, Declared us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption Cumulative effect of change in accounting principle Increases in tax positions for prior period Increases in tax positions during current period us-gaap_ProceedsFromIssuanceOfLongTermDebt Proceeds from Issuance of Long-term Debt, Total us-gaap_ProceedsFromConvertibleDebt Proceeds from Convertible Debt us-gaap_ProceedsFromLongTermLinesOfCredit Proceeds from Long-term Lines of Credit amrs_LineOfCreditFacilityIncrementalDrawDownAmount Line of Credit Facility, Incremental Draw Down Amount Represents the line of credit facility, incremental draw down amount. Deferred rent, net of current portion us-gaap_TaxCreditCarryforwardAmount Tax Credit Carryforward, Amount Weighted-average shares of common stock outstanding used in computing net loss per share of common stock, basic and diluted (in shares) Weighted-average shares of common stock outstanding used in computing net loss per share of common stock, basic and diluted (in shares) us-gaap_SharePrice Share Price Research Tax Credit Carryforward [Member] Antidilutive securities (in shares) us-gaap_RepaymentsOfLinesOfCredit Repayments of Lines of Credit Reclassifications [Member] Represents the information pertaining to the reclassifications. Tax Credit Carryforward [Axis] amrs_DebtIssuanceCostsIncurredInConnectionWithDebtInstrumentAccountedAtFairValue Debt issuance costs incurred in connection with debt instrument accounted at fair value The amount of debt issuance costs incurred in connection with debt instrument accounted at fair value. Tax Credit Carryforward, Name [Domain] Basic and diluted loss per share (in dollars per share) Basic and diluted loss per share (in dollars per share) us-gaap_OperatingLossCarryforwards Operating Loss Carryforwards, Total Corrections [Member] Represents the information pertaining to the corrections. Settlement of derivatives liability upon exercise of warrants Amount of increase in additional paid in capital (APIC) resulting from the settlement of derivative liability upon exercise of warrants. Statement of Financial Position [Abstract] us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments Other Issuance of preferred stock attributed to derivative liabilities Issuance of preferred stock attributed to derivative liabilities Amount of proceeds from issuance of preferred stock that is attributable to derivativeliabilities. amrs_NoncashRevenueReductionRelatedToIssuanceOfDebtObligations Noncash revenue reduction related to issuance of debt obligations under Ginkgo Partnership Agreement The amount of noncash revenue reduction related to issuance of debt obligations. Effective income tax rate amrs_ReversalOfRemainingUnrecognizedDeferredRevenueLiability Reversal of Remaining Unrecognized Deferred Revenue Liability Represents reversal of remaining unrecognized deferred revenue liability. Accounts Payable [Member] Change in U.S. federal tax rate us-gaap_ProceedsFromRepaymentsOfLinesOfCredit Proceeds from (Repayments of) Lines of Credit, Total DSM Licneses [Member] Represents information related to DSM licenses Contract with Customer, Asset and Liability [Table Text Block] Warrants Issued in Exchange for August 2013 Financing Convertible Note [Member] Represents the warrants issued in exchange of the August 2013 Financing Convertible Note. Change in valuation allowance Statement of Cash Flows [Abstract] Preferred Stock Series A and Series B [Member] Represents preferred stock series A and Series B Statement of Stockholders' Equity [Abstract] Schedule of Disclosure on Geographic Areas, Long-Lived Assets in Individual Foreign Countries by Country [Table Text Block] Proceeds from issuance of debt, net of issuance costs Proceeds from issuance of debt, net of issuance costs us-gaap_RepaymentsOfDebt Repayments of Debt Other Noncurrent Liabilities [Table Text Block] Asset retirement obligation(1) Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block] Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block] Schedule of Components of Income Tax Expense (Benefit) [Table Text Block] Schedule of Deferred Tax Assets and Liabilities [Table Text Block] Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] Stock-based compensation us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost State taxes, net of federal tax benefit Financing activities Accounts receivable, net us-gaap_AccountsReceivableRelatedParties Accounts Receivable, Related Parties us-gaap_NotesReceivableRelatedParties Notes Receivable, Related Parties us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent Statutory tax rate Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] us-gaap_ConvertibleDebtFairValueDisclosures Convertible Debt, Fair Value Disclosures Customer C [Member] Represents information pertaining to Customer C. Customer G [Member] Represents information pertaining to Customer G. us-gaap_ProceedsFromEquityMethodInvestmentDividendsOrDistributionsReturnOfCapital Proceeds from Equity Method Investment, Distribution, Return of Capital Revenues [Member] Represents information pertaining to revenues. Customer E [Member] Represents information pertaining to Customer E. Accounts receivable - related party, net Accounts receivable - related party, net Accounts receivable related party, net of allowance of $0 and $23, respectively Series C Preferred Stock [Member] Series D Preferred Stock [Member] Series A Preferred Stock [Member] Period-end Common Stock Warrants [Member] Represents information pertaining to period-end common stock warrants. Series B Preferred Stock [Member] Proceeds from divestiture, net of cash transferred Proceeds from Divestiture of Businesses Tranche I Notes [Member] Represents information pertaining to the Tranche I Notes. Tranche II Notes [Member] Represents information pertaining to the Tranche II Notes. Rule 144A Convertible Note Offering [Member] Represents the Rule 144A Convertible Note Offering. Class of Stock [Axis] Class of Stock [Domain] Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] us-gaap_PaymentsToAcquireBusinessesGross Payments to Acquire Businesses, Gross Schedule of Derivative Liabilities at Fair Value [Table Text Block] us-gaap_DerivativeNotionalAmount Derivative, Notional Amount Income Tax Disclosure [Text Block] Schedule of Debt [Table Text Block] Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Share-based Payment Arrangement, Option and Stock Appreciation Rights, Activity [Table Text Block] Financing of insurance premium under note payable The amount financing of the insurance premium in a noncash (or part noncash) acquisition. Noncash is defined as information about all investing and financing activities of an enterprise during a period that affect recognized assets or liabilities but that do not result in cash receipts or cash payments in the period. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or cash payments in the period. amrs_PaymentsToAcquirePropertyPlantAndEquipmentNetOfDisposals Purchases of property, plant and equipment Purchases of property, plant and equipment The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets, net of disposals. Share-based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block] Accrued interest added to debt principal The element that represents capitalized interest, shown on the cash flow statement under "supplemental disclosures of non-cash investing and financing activities." Liquidity [Policy Text Block] Disclosure for the policy related to the liquidity of the company. amrs_PaymentsForDerivativeTermination Payment of swap termination Payment of swap termination The cash outflows used to terminate derivative swaps during the period. amrs_ConvertibleNoteOffering Convertible Note Offering Represents the convertible note offering. amrs_ReceiptOfNoncashConsiderationInConnectionWithLicenseRevenue Receipt of noncash consideration in connection with license revenue Receipt of noncash consideration in connection with license revenue The amount that represents the receipt of noncash consideration in connection with license revenue. Freestanding derivative instruments in connection with the issuance of equity instruments Fair value of equity conversion feature freestanding derivative liability. DSM [Member] Represents information related to the entity DSM. Total and Temasek [Member] Represents related parties Total and Temasek. amrs_DivestitureOfBusinessConsiderationTransferred Divestiture of Business, Consideration Transferred The total amount of consideration transferred in relation to the divestiture of a business, branch, or division. Proceeds from issuance of convertible preferred stock Proceeds from issuance of convertible preferred stock The cash inflow from issuance of preferred stocks, net of issuance costs. Machinery, Equipment, and Fixtures [Member] Related to machinery, equipment, and fixtures. Denominator [Member] Represents the denominator in the ratio. The DSM Credit Letter [Member] Related to the DSM credit letter. amrs_EffectiveIncomeTaxRateReconciliationDerivativeLiability Derivative liability Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to derivative liability. amrs_ConvertibleNoteSubstantialChangeDiscountRateUsedInCalculateValueOfRemainingInterestPayments Convertible Note Substantial Change, Discount Rate Used in Calculate Value of Remaining Interest Payments Represents the discount rate used in calculating the value of the remaining interest payments if the substantial change covenants are triggered. Vivo Cash Warrants [Member] Related to the Vivo Cash Warrants. Total Purchase Agreement [Member] Represents the Total Purchase Agreement. amrs_PreferredStockBeneficialConversionFeature Preferred Stock, Beneficial Conversion Feature Amount of a favorable spread to a preferred stock holder between the amount of preferred stock being converted and the value of the securities received upon conversion. amrs_ConsiderationTransferred Consideration Transferred The amount of consideration transferred in accordance with certain agreements. Nondeductible interest Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to non-deductible interest. Foreign losses Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to foreign losses Capitalized start-up costs Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from capitalized start-up costs. Cash Warrants [Member] Related to the cash warrants. May 2017 Dilution Warrants [Member] Related to the may 2017 dilution warrants. amrs_DeferredTaxAssetsLiabilitiesGross Net deferred tax assets prior to valuation allowance Amount, after allocation of deferred tax liability, but before allocation of valuation allowances, of deferred tax asset attributable to deductible differences and carryforwards, before jurisdictional netting. amrs_LiabilityReversalForTheConsiderationRecordedRelatedToDeferredRevenueNowBeingTerminated Liability Reversal For The Consideration Recorded Related to Deferred Revenue Now Being Terminated The amount of liability being reversed in regards to the consideration recorded for deferred revenue which is now being terminated. Amyris Brasil [Member] Related to the entity Amyris Brasil. Sale of short-term investments Maturities of short-term investments us-gaap_ProceedsFromSaleMaturityAndCollectionOfShorttermInvestments Change in short-term investments us-gaap_PaymentsToAcquireShortTermInvestments Purchase of short-term investments May 2017 warrants , May 2017 Offering Make Whole Provision [Member] Refers to information regarding May 2017 warrants, May 2017 Offering, and the Make Whole Provision. Embedded derivatives in connection with the issuance of debt and equity instruments Equity Conversion Feature Embedded Derivative Liability Fair Value Disclosures Fair value of equity conversion feature embedded derivative liability. amrs_DebtInstrumentCovenantTermsMinimumAmountOfTransactionsRequiringConsentOfNoteholders Debt Instrument Covenant Terms Minimum Amount Of Transactions Requiring Consent Of Noteholders The debt instrument covenant terms minimum amount of transactions requiring consent of noteholders. Equity Incentive Plan, 2010 [Member] Represents the equity incentive plan from 2010. amrs_SharesAvailableForIssuancePercentageOfTotalOutstandingShares Shares Available for Issuance, Percentage of Total Outstanding Shares Represents shares available for issuance as percentage of total outstanding shares. Issuance of note payable in exchange for debt extinguishment with third party The value of notes issued for debt extinguishment. Credit Facility [Axis] amrs_ContingentConsiderationLiability Contingent Consideration Liability The amount of liability accrued from certain contingent considerations. amrs_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsPeriodAvailableToGrant Share-based Compensation Arrangement by Share-based Payment Award, Options, Period Available to Grant Represents the period available to grant awards. Credit Facility [Domain] amrs_CreditLetter Credit Letter Represents the amount of credit letter. amrs_SupplyAgreementRenewableTerms Supply Agreement, Renewable Terms The renewable terms of supply agreements once the initial agreement has expired. amrs_SharebasedCompensationArrangementBySharebasedPaymentAwardMinimumPercentOfShareholderTriggeringHigherExercisePrice Share-based Compensation Arrangement by Share-based Payment Award, Minimum Percent of Shareholder Triggering Higher Exercise Price Represents minimum percent of shareholder triggering higher exercise price. amrs_CreditUtilizationLikelihoodPercentage Credit Utilization Likelihood Percentage Represents the percentage of likelihood the credit will be utilized. amrs_SharebasedCompensationArrangementBySharebasedPaymentAwardMinimumPercentOfExecrisePriceToFairMarketValueOnGrantDate Share-based Compensation Arrangement by Share-based Payment Award, Minimum Percent of Execrise Price to Fair Market Value on Grant Date Minimum percent of exercise price to fair market value on date of grant. Intellectual Property License [Member] Information pertaining to the intellectual property license. Supply Agreements [Member] Contractual agreements that involve two or more parties in the agreement to provide supplies. Settlement of debt principal by a related party The value of debt settled on behalf of the company by a related party. Property, Plant and Equipment, Including Capital Leases [Member] Property plant and equipment including capital leases. Unsecured Promissory Note [Member] Information pertaining to the unsecured promissory note. Machinery and Equipment, Furniture and Office Equipment Under Capital Lease [Member] Represents property, plant and equipment classified as machinery and equipment, furniture and office equipment, under a capital lease. amrs_SharebasedCompensationArrangementBySharebasedPaymentAwardMinimumPercentOfExecrisePriceToFairMarketValueOnGrantDateOfTenPercentOrGreaterShareholderOfCompany Share-based Compensation Arrangement by Share-based Payment Award, Minimum Percent of Execrise Price to Fair Market Value on Grant Date of Ten Percent or Greater Shareholder of Company Represents minimum percent of exercise price to fair market value on grant date of ten percent or greater shareholder of company. Employee Stock Purchase Plan, 2010 [Member] Represents the 2010 employee stock purchase plan. Stock Options and Stock Issuance Plans, 2005 [Member] Represents the 2005 stock options and stock issuance plans. amrs_ConvertiblePromissoryNoteAdditionalPrincipalAmountIssuedDuringPeriod Convertible Promissory Note, Additional Principal Amount Issued During Period Represents the additional principal amount issued during the period under a convertible promissory note. us-gaap_PaymentsToAcquirePropertyPlantAndEquipment Payments to Acquire Property, Plant, and Equipment, Total Computer Equipment and Software [Member] Represents computer equipment and software. amrs_ConvertibleDebtBeneficialCommonStockOwnershipMaximumPercentageExceptUnderSpecifiedConditions Convertible Debt, Beneficial Common Stock Ownership, Maximum Percentage Except Under Specified Conditions Represents the maximum percentage of beneficial common stock ownership under a convertible debt instrument, unless certain specified conditions are met. Recoverable taxes from Brazilian government entities Recoverable taxes from Brazilian government entities The element that represents recoverable taxes on the purchase of fixed assets. amrs_ConvertibleDebtBeneficialCommonStockOwnershipMaximumPercentageUnderSpecifiedConditions Convertible Debt, Beneficial Common Stock Ownership, Maximum Percentage Under Specified Conditions Represents the maximum percentage of beneficial common stock ownership under a convertible debt instrument, if certain specified conditions are met. Schedule of Accrued and Other Current Liabilities [Table Text Block] Tabular disclosure of accrued and other current liabilities. amrs_ConvertibleDebtBeneficialCommonStockOwnershipMaximumPercentageConditionsNumberOfDaysAfterWrittenNotice Convertible Debt, Beneficial Common Stock Ownership, Maximum Percentage, Conditions, Number of Days After Written Notice Represents the number of days of written notice required to be provided, after which the maximum percentage beneficial common stock ownership may be the higher of the two possible thresholds specified. amrs_ConvertibleDebtAggregateNumberOfSharesIssuedWithRespectToTheInitialClosingMaximum Convertible Debt, Aggregate Number of Shares Issued With Respect to the Initial Closing, Maximum Represents the maximum number of shares issueable with respect to the initial closing under a convertible debt instrument. Supplemental disclosures of cash flow information: Debt, current portion, fair value Long-term Debt, Fair Value Net loss attributable to Amyris, Inc. common stockholders us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic Net loss attributable to Amyris, Inc. common stockholders Net loss attributable to Amyris, Inc. common stockholders Related Party Convertible Notes [Member] Represents information about related party convertible notes. Stegodon [Member] Represents information pertaining to Stegodon Corporation. 2021 Represents the portion of the future minimum payments on debt that is due in three years. August 2013 Convertible Notes [Member] Represents August 2013 convertible notes. 2020 Represents the portion of the future minimum payments on debt that is due in two years. us-gaap_DebtDefaultLongtermDebtAmount Debt Instrument, Debt Default, Amount Senior Secured Convertible Note [Member] Represents senior secured convertible note. us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesBasic Add: losses allocated to participating securities Add: losses allocated to participating securities March 2014 Letter Agreement [Member] Represents March 2014 letter agreement. Ginkgo Collaboration Agreement [Member] Represents information pertaining to the Ginkgo Collaboration Agreement. 2023 Represents the portion of the future minimum payments on debt that is due in five years. amrs_DebtFutureMinimumPaymentsDueInFourYears 2022 Represents the portion of the future minimum payments on debt that is due in four years. Thereafter Represents the portion of the future minimum payments on debt that is due after five years. Nikko Note [Member] Represents information pertaining to the Nikko Note. amrs_DebtFutureMinimumPaymentsInterestIncludedInPayments Less: amount representing interest(1) Represents the interest that is included in future payments on debt, which amount is subtracted from total future minimum payments in order to calculate the present value of minimum debt payments. Contingent Consideration by Type [Axis] Nikko [Member] Represents information pertaining to Nikko Chemicals Co., Ltd. amrs_DebtFutureMinimumPaymentsDue Total future minimum payments Represents the total future minimum payments that will be due on debt. us-gaap_IncreaseDecreaseOfRestrictedInvestments Change in restricted cash Contingent Consideration Type [Domain] amrs_DebtFutureMinimumPaymentsPresentValueOfNetMinimumPaymentsCurrentMaturities Less: current portion of debt principal Represents the current portion of the present value of the net minimum payments on debt. amrs_DebtFutureMinimumPaymentsPresentValueOfNetMinimumPayments Present value of minimum debt payments Represents the present value of future minimum debt payments, net of interest. amrs_DebtInstrumentAdditionalEqualMonthlyInstallmentsAmount Debt Instrument, Additional Equal Monthly Installments, Amount Represents the amount of each additional equal monthly installment to be paid under a debt instrument. amrs_DebtInstrumentPercentageOfJointVentureInterestsOwnedByTheCompanySecuringTheDebtInstrument Debt Instrument, Percentage of Joint Venture Interests Owned By the Company Securing the Debt Instrument Represents the percentage of the company's joint venture interests securing the debt instrument. amrs_DebtInstrumentAdditionalPaymentsRequiredInFourMonthlyInstallments Debt Instrument, Additional Payments Required in Four Monthly Installments Represents the additional payments required in four monthly payments under the debt instrument. First Tranche [Member] Represents the first tranche. us-gaap_PreferredStockDividendsIncomeStatementImpact Less cumulative dividends on Series A and Series B preferred stock Conversion of All Outstanding Fidelity Notes for Aggregate Principal Amount of 2015 144A Notes [Member] Represents information pertaining to the conversion of all outstanding Fidelity Notes, together with accrued and unpaid interest thereon, for aggregate principal amount of 2015 144A Notes. Second Tranche [Member] Represents the second tranche. Net loss Net loss attributable to Amyris, Inc. Net loss Restricted Stock Units (RSUs) [Member] Restricted Stock [Member] 2019 Represents the future minimum payments on debt that are due in the next fiscal year following the latest fiscal year. Share-based Payment Arrangement, Option [Member] amrs_ConvertiblePromissoryNotesPeriodAfterWhichNotesWillBeDue Convertible Promissory Notes, Period After Which Notes Will Be Due Represents the period of time after which convertible promissory notes will be due and will be convertible into shares of common stock at the specified conversion price. Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Antidilutive Securities [Axis] Antidilutive Securities, Name [Domain] Biolding Investment SA [Member] Represents Biolding Investment stockholder. amrs_PlantManufacturingProductionProductSalesPercentage Plant Manufacturing Production, Product Sales, Percentage Represents the percentage of gross margins from product sales that, if failed to achieve, will reduce the conversion price of the notes. Firmenich [Member] Represents information pertaining to Firmenich S.A., a global flavors and fragrances company. Ginkgo Collaboration Note [Member] Represents the secured promissory note to Ginkgo. Unsecured Debt [Member] Long-term Debt, Type [Axis] California Franchise Tax Board [Member] Long-term Debt, Type [Domain] Calculated under Revenue Guidance in Effect before Topic 606 [Member] amrs_DebtInstrumentConvertibleConversionPriceInterestAccrued Debt Instrument, Convertible, Conversion Price, Interest Accrued Represents the rate of interest at which interest accrues, compounded annually, assuming no default. Capital Lease Obligations [Member] Additional paid-in capital Additional paid-in capital Value received from shareholders in common stock-related transactions that are in excess of par value or stated value and amounts received from other stock-related transactions and amount of additional paid-in capital (APIC) classified as other. us-gaap_CapitalLeasesFutureMinimumPaymentsDueThereafter Capital leases thereafter us-gaap_CapitalLeasesFutureMinimumPaymentsDue Total future minimum capital lease payments Series B Convertible Preferred Stock [Member] Represents information about Series B Convertible Preferred Stock. us-gaap_EquityMethodInvestmentOwnershipPercentage Equity Method Investment, Ownership Percentage Work in process Amount, including adjustments, of merchandise or goods in the production process expected to be completed within one year or operating cycle, if longer. 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Extinguishment of Debt, Type [Domain] Revenues, related party us-gaap_RelatedPartyCosts Related Party Costs Earnings Per Share [Text Block] us-gaap_ExtinguishmentOfDebtAmount Extinguishment of Debt, Amount us-gaap_CapitalLeasesFutureMinimumPaymentsInterestIncludedInPayments Less: amount representing interest us-gaap_IncreaseDecreaseInDerivativeLiabilities Increase (Decrease) in Derivative Liabilities BRAZIL Extinguishment of Debt [Axis] DSM Warrants [Member] Information pertaining to the DSM Warrants. us-gaap_RelatedPartyTransactionPurchasesFromRelatedParty Related Party Transaction, Purchases from Related Party Related Party Transactions Disclosure [Text Block] us-gaap_CapitalLeasesFutureMinimumPaymentsPresentValueOfNetMinimumPayments Present value of minimum lease payments us-gaap_IncreaseDecreaseInAccountsPayable Accounts payable us-gaap_IncreaseDecreaseInNotesPayableCurrent Increase (Decrease) in Notes Payable, Current, Total Rule 144A Convertible Notes [Member] Represents Rule 144A Convertible Notes. us-gaap_DebtInstrumentTerm Debt Instrument, Term Tranche Notes [Member] Represents Tranche Notes. us-gaap_DebtInstrumentDecreaseForgiveness Debt Instrument, Decrease, Forgiveness us-gaap_DebtInstrumentConvertibleConversionPrice1 Debt Instrument, Convertible, Conversion Price Allocated share-based compensation expense Share-based Payment Arrangement, Expense us-gaap_DebtInstrumentConvertibleConversionRatio1 Debt Instrument, Convertible, Conversion Ratio us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings Change in fair value Number of shares into which debt instrument is convertible Ginkgo Bioworks [Member] Represents the Ginkio Bioworks organization. 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Options granted (in shares) us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod Forfeited or expired (in shares) us-gaap_WarrantsAndRightsOutstandingTerm Warrants and Rights Outstanding, Term Line of Credit Facility, Lender [Domain] Collaborative Arrangement and Arrangement Other than Collaborative [Domain] Collaborative Arrangement [Member] Issuance of common stock for cash (in shares) Stock Issued During Period, Shares, New Issues Lender Name [Axis] Total liabilities, mezzanine equity and stockholders' deficit us-gaap_LiabilitiesAndStockholdersEquity Total liabilities, mezzanine equity and stockholders' deficit Issuance of Series A preferred stock for cash Stock Issued During Period, Value, New Issues UNITED STATES us-gaap_DerivativeLiabilityMeasurementInput Derivative liabilities, measurement input us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability Embedded Derivative, Fair Value of Embedded Derivative Liability amrs_GainLossFromFairValueAdjustmentInCollaborationAgreement Gain (Loss) From Fair Value Adjustment in Collaboration Agreement The amount gain (loss) from fair value adjustment in collaboration agreement. Measurement Input, Credit Spread [Member] us-gaap_IncreaseDecreaseInContractWithCustomerAsset Accounts receivable, unbilled – related party Accounts receivable, unbilled – related party Accumulated deficit Accumulated deficit Retained Earnings (Accumulated Deficit), Ending Balance Accumulated other comprehensive loss Accumulated other comprehensive loss amrs_DebtInstrumentRequirementUnrestrictedUnencumberedCash Debt Instrument, Requirement, Unrestricted, Unencumbered Cash The amount of unrestricted, unencumbered cash required to maintain pursuant to the debt agreement. Money Market Funds [Member] Measurement Input, Discount Rate [Member] amrs_FairValueAdjustmentOfDebt Fair Value Adjustment of Debt The amount of fair value adjustment to debt liabilities. DSM November 2018 Supply Agreement Amendment [Member] Represents information pertaining to DSM November 2018 Supply Agreement Amendment. Debt Disclosure [Text Block] amrs_ClassOfWarrantOrRightAdditionalNumberOfSecuritiesCalledByWarrantsOrRights Class of Warrant or Right, Additional Number of Securities Called by Warrants or Rights The additional number of securities called by warrants or rights due to the change of conversion price on related convertible notes. amrs_CashReservationFeePayable Cash Reservation Fee, Payable The amount of cash reservation fee pursuant to the agreement. Cash and Cash Equivalents [Axis] August 2018 New Warrants [Member] Represents a series of new warrants issused related to the August 2018 warrant transactions. DSM Value Sharing Agreement [Member] Represents the information pertaining to the DSM Value Sharing Agreement. Cash and Cash Equivalents [Domain] Cash Warrants and Dilution Warrants [Member] Represents the information pertaining to Cash Warrants and Dilution Warrants. amrs_PaymentsForDebtAgreementAmendment Payments for debt agreement amendment The cash outflow for the debt agreement amendment. amrs_AllowanceForDoubtfulAccountsReceivableExcludingRelatedPartiesCurrent Accounts receivable, allowance A valuation allowance for trade and other receivables due to an Entity, excluding related parties transaction, within one year (or the normal operating cycle, whichever is longer) that are expected to be uncollectible. Measurement Input, Price Volatility [Member] Accounts receivable, net Accounts receivable, net Accounts receivable, net of allowance of $642 and $619, respectively Amount, after allowance for credit loss, of right to consideration from customer for product sold and service rendered in normal course of business, classified as current, excluding amount receivable from related parties. Changes in assets and liabilities: amrs_ContingentFeeSharePriceTrigger Contingent Fee, Share Price Trigger The share price that would trigger the contingent fee. amrs_CashFee Cash Fee The amount of cash fee pay to the counter party. 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Product and Service [Domain] DSM Dilution Warrant [Member] Represents the information pertaining to the DSM Dilution Warrant. Statistical Measurement [Axis] Mezzanine Equity, Common Stock [Member] Represents information about Mezzanine Equity-Common Stock. Investment, Name [Domain] us-gaap_OperatingLeasesRentExpenseSubleaseRentals1 Operating Leases, Rent Expense, Sublease Rentals us-gaap_PaymentsForFees Payments for Other Fees amrs_DeemedDividendBeneficialConversionFeatureOnSeriesAPreferredStock Deemed Dividend, Beneficial Conversion Feature on Series A Preferred Stock Less deemed dividend related to beneficial conversion feature on Series A preferred stock Less deemed dividend related to beneficial conversion feature on Series A preferred stock Represents the amount of deemed dividend related to beneficial conversion feature on series A preferred Stock. Preferred stock Preferred stock - $0.0001 par value, 5,000,000 shares authorized as of December 31, 2018 and 2017, and 14,656 and 22,171 shares issued and outstanding as of December 31, 2018 and 2017, respectively Preferred Stock, Value, Issued, Ending Balance Ownership [Axis] Series D Convertible Preferred Stock [Member] The outstanding series D preferred stock that may be exchanged into common shares or other types of securities at the owner's option. Preferred stock, shares issued (in shares) Vivo Capital LLC [Member] Represents the information pertaining to the Vivo Capital LLC. Cash paid for interest Securities Purchase Agreement [Member] Represents the information pertaining to the agreement between Vivo Purchase Agreement, together with the DSM Purchase Agreement. Investment, Name [Axis] Geographical [Axis] Property, Plant and Equipment [Table Text Block] Geographical [Domain] Preferred stock, shares authorized (in shares) Europe [Member] amrs_ReceiptOfEquityInConnectionWithCollaborationArrangementsRevenue Receipt of equity in connection with collaboration arrangements revenue The amount that represents the receipt of equity in connection with collaboration arrangements revenue. Preferred stock, par value (in dollars per share) Preferred Stock, Par or Stated Value Per Share August 2017 Vito Dilution Warrants [Member] Represents the information pertaining to the Vito Dilution Warrants issued in August 2017. us-gaap_ProceedsFromCollaborators Proceeds from Collaborators Issuance of convertible preferred stock upon conversion of debt The fair value of convertible preferred stock issued upon conversion of debt in noncash financing activities. Fair Value, Inputs, Level 3 [Member] Fair Value Hierarchy and NAV [Domain] Customer [Axis] Customer [Domain] Fair Value, Inputs, Level 1 [Member] Fair Value, Inputs, Level 2 [Member] Fair Value Hierarchy and NAV [Axis] amrs_ConvertiblePreferredStockProceedsAllocatedToPreferredStock Convertible Preferred Stock, Proceeds Allocated to Preferred Stock The amount of proceeds allocated to preferred stock subsequent to the recognition of the beneficial conversion feature. us-gaap_PreferredStockCapitalSharesReservedForFutureIssuance Preferred Stock, Capital Shares Reserved for Future Issuance Series A Preferred Stock Converted Into Common Stock [Member] Represents the conversion of Series A Preferred Stock to Common Stock. Due to Related Parties [Member] Represents obligations due to related parties. amrs_ConvertiblePreferredStockBeneficialConversionFeatureProceedsAllocatedToPreferredStock Convertible Preferred Stock, Beneficial Conversion Feature, Proceeds Allocated to Preferred Stock The amount of proceeds allocated to the preferred stock in related to the beneficial conversion feature of convertible preferred stock. amrs_StockIssuanceCostsRecognized Stock Issuance Costs Recognized The incurred in related to the issuance of stocks. amrs_DeemedDividendBeneficialConversionFeatureOnSeriesBPreferredStock Less deemed dividend related to beneficial conversion feature on Series B preferred stock Less deemed dividend related to beneficial conversion feature on Series B preferred stock Represents the amount of deemed dividend related to beneficial conversion feature on series B preferred Stock. amrs_DeemedDividendBeneficialConversionFeatureOnSeriesDPreferredStock Less deemed dividend related to beneficial conversion feature on Series D preferred stock Less deemed dividend related to beneficial conversion feature on Series D preferred stock Represents the amount of deemed dividend related to beneficial conversion feature on series D preferred Stock. us-gaap_PreferredStockDividendRatePercentage Preferred Stock, Dividend Rate, Percentage Noncontrolling interest Noncontrolling interest Operating activities Beneficial conversion feature of preferred stock The amount of preferred stock conversions. us-gaap_WarrantsAndRightsOutstanding Warrants and Rights Outstanding Statement [Line Items] amrs_IncreaseDecreaseOfRecoverableTaxesOnPurchaseOfFixedAssets Prepaid expenses and other assets Prepaid expenses and other assets Represents the amount of increase (decrease) of recoverable taxes on the purchase of fixed assets. AOCI Attributable to Parent [Member] Stockholders’ deficit: Furniture and Office Equipment, Vehicles and Land [Member] Equipment commonly used in offices, vehicles used for road transportation, and real estate held. Other us-gaap_OtherAssetsMiscellaneousNoncurrent Accounting Standards Update 2017-11 [Member] Schedule of Other Assets, Noncurrent [Table Text Block] us-gaap_ContractWithCustomerAssetCumulativeCatchUpAdjustmentToRevenueModificationOfContract Contract with Customer, Asset, Cumulative Catch-up Adjustment to Revenue, Modification of Contract License and Service [Member] Mezzanine Equity Mezzanine Equity License [Member] Total liabilities us-gaap_Liabilities Liabilities, Total Total liabilities Commitments and contingencies (Note 9) Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Table Text Block] us-gaap_ContractWithCustomerLiabilityRevenueRecognized Contract with Customer, Liability, Revenue Recognized Prepaid expenses and other current assets Prepaid expenses and other current assets Total prepaid expenses and other current assets Liabilities us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities Counterparty Name [Axis] Counterparty Name [Domain] Accounting Standards Update 2014-09 [Member] Assets us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets us-gaap_ContractWithCustomerLiability Contract with Customer, Liability, Total Derivative liabilities Derivative Liability, Total Accounting Standards Update 2016-02 [Member] us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestAccrued Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued, Total Other Other Credit Facilities [Member] Represents other credit facilities not otherwise disclosed. Other Loans Payable [Member] Represents other loans payable. Type of Adoption [Domain] Aprinnova JV [Member] Represents information pertaining to Aprinnova, LLC, a joint venture. Aprinnova Notes [Member] Information pertaining to the Aprinnova Notes. us-gaap_LettersOfCreditOutstandingAmount Letters of Credit Outstanding, Amount Adjustments for New Accounting Pronouncements [Axis] May 2017 Offering Closing [Member] Sale of Series A & B Preferred Stock and May 2017 Warrants. Series A Preferred Stock and Warrants [Member] Represents Series A Preferred Stock and May 2017 Warrants. Disposal Group Classification [Axis] Disposal Group Classification [Domain] Mezzanine Equity Disclosure [Text Block] The entire disclosure of mezzanine equity. Disposal Group, Not Discontinued Operations [Member] amrs_PreferredStockAnniversaryPayment Preferred Stock, Anniversary Payment The amount of payment, per share, made to Preferred Stockholders if conversion occurs prior to the 10th anniversary of the date of issuance. amrs_BeneficiaryOwnershipConversionPercentageMaximum Beneficiary Ownership, Conversion Percentage, Maximum The amount of ownership percentage of common stock established on the conversion of preferred stock. Series B Preferred Stock and Warrants [Member] Represents Series B Preferred Stock and May 2017 Warrants. amrs_PreferredStockConversionPricePerShareToCommonStock Preferred Stock, Conversion Price Per Share to Common Stock The per share price of the conversion of preferred stock to common stock. The 2015 144A Notes [Member] Information pertaining to the 2015 144A Notes. May 2017 Warrants, Warrant 1 [Member] The first group of warrants issued in the May 2017 Offering Closing. May 2017 Warrants [Member] Information pertaining to the May 2017 Warrants. The 2014 144A Notes [Member] Information pertaining to the 2014 144A Notes. Dilution Warrants [Member] Information pertaining to the Dilution Warrants in the May 2017 Offering Closing. Issuance of common stock upon exercise of warrants Amount of increase in additional paid in capital (APIC) resulting from the exercise of warrants. DSM International B.V. [Member] Represents information pertaining to DSM International B.V. July 2015 PIPE Warrants [Member] Information pertaining to the July 2015 PIPE Warrants. May 2017 Warrants, Warrant 2 [Member] The second warrant issued in the May 2017 Offering Closing. Series A and Series B Preferred Stock [Member] Represents both Series A and Series B preferred Stock. Issuance of common stock upon exercise of warrants (in shares) Stock Issued During Period, Shares, Warrants Exercised Exercises (in shares) Number of shares issued during the period as a result of exercise of warrants. Foris and Naxyris [Member] Information pertaining to both Foris and Naxyris. Noncontrolling Interest [Member] amrs_ReservedSecondTrancheSecurities Reserved Second Tranche Securities The amount of Preferred Stock Securities and Warrants reserved to be pursuant to the stockholder agreement. Additional Warrants Issued (in shares) Class of Warrants or Right, Issued in Period The number of warrants or rights issued during the reporting period. Cost of Goods and Service [Policy Text Block] amrs_SecondTrancheClosingAnniversaryPayment Second Tranche Closing, Anniversary Payment The amount of cash payments to be made annually contingent on the Second Tranche closing, not exceeding the funding amount. amrs_CreditToCollaborationAgreements Credit to Collaboration Agreements Represents the amount of credit available in collaboration agreements that will offset collaboration payments received. amrs_IncreaseDecreaseInRevenue Increase (Decrease) in Revenue The increase (decrease) in revenue earned in the period. Retained Earnings [Member] Reverse Stock Split [Member] The conversion of a reverse stock split where there is a reduction in the shares outstanding. Temasek Funding Warrant [Member] The granted warrants to Temasek to purchase the Company’s common stock. amrs_PreferredStockStatedValue Preferred Stock, Stated Value The stated value of preferred stock. amrs_DesignatedHolderMaximumCommonStockOwnership Designated Holder Maximum Common Stock Ownership Maximum percentage interest in company's common stock allowed under Stockholder Agreement. Conversion of Common Stock Into Series C Preferred Stock [Member] Related to the conversion of common stock into Series C preferred stock. amrs_PreferredStockEffectiveConversionPrice Preferred Stock Effective Conversion Price The effective conversion price of preferred stock. 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Selling, General and Administrative Expenses [Member] amrs_CapitalLeasesAndOperatingLeasesFutureMinimumPaymentsDueNextTwelveMonths Total lease obligations 2019 Represents the future minimum payments due in the next twelve months under capital leases and operating leases. amrs_CapitalLeasesAndOperatingLeasesFutureMinimumPaymentsDueDueInTwoYears Total lease obligations 2020 Represents the future minimum payments due in two years under capital leases and operating leases. Title of 12(b) Security amrs_CapitalLeasesAndOperatingLeasesFutureMinimumPaymentsDueDueInFourYears Total lease obligations 2022 Represents the future minimum payments due in four years under capital leases and operating leases. amrs_CapitalLeasesAndOperatingLeasesFutureMinimumPaymentsDueDueInThreeYears Total lease obligations 2021 Represents the future minimum payments due in three years under capital leases and operating leases. amrs_CapitalLeasesAndOperatingLeasesFutureMinimumPaymentsDueDueInFiveYears Total lease obligations 2023 Represents the future minimum payments due in five years under capital leases and operating leases. amrs_CapitalLeasesAndOperatingLeasesFutureMinimumPaymentsDue Total future minimum lease payments Represents the total future minimum payments due under capital leases and operating leases. amrs_CapitalLeasesAndOperatingLeasesFutureMinimumPaymentsDueDueThereafter Total lease obligations thereafter Represents the future minimum payments due after five years under capital leases and operating leases. Research and Development Expense [Member] Income Statement Location [Axis] Income Statement Location [Domain] Nonmonetary Transaction Type [Domain] Collaborative Arrangement and Arrangement Other than Collaborative [Axis] Collaborative Arrangement Disclosure [Text Block] Nonmonetary Transaction Type [Axis] Novvi LLC [Member] Investee by the name of Novvi LLC. us-gaap_ContractualObligation Contractual Obligation, Total Statement [Table] us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter Operating leases thereafter us-gaap_OperatingLeasesFutureMinimumPaymentsDue Total future minimum operating lease payments us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears Operating leases 2022 us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears Operating leases 2023 us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears Operating leases 2020 us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears Operating leases 2021 us-gaap_DisposalGroupIncludingDiscontinuedOperationConsideration Disposal Group, Including Discontinued Operation, Consideration Income Statement [Abstract] us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent Operating leases 2019 Disposal Group Name [Axis] Disposal Group Name [Domain] Disposal Groups, Including Discontinued Operations, Disclosure [Text Block] Schedule of New Accounting Pronouncements and Changes in Accounting Principles [Table Text Block] Temasek [Member] Represents Temasek. amrs_ClassOfWarrantOrRightCashlessExerciseProvisionNumberExercised Class Of Warrant Or Right, Cashless Exercise Provision, Number Exercised Represents the number of warrants that were exercised during the period through the cashless exercise provision. Other noncurrent liabilities Other noncurrent liabilities Total other noncurrent liabilities Related party debt, net of current portion Related party debt, net of current portion Accounts receivable, related party, allowance A valuation allowance for trade and other receivables due to an Entity from related parties within one year (or the normal operating cycle, whichever is longer) that are expected to be uncollectible. Accounting Changes and Error Corrections [Text Block] Gates Foundation Purchase Agreement [Member] A security purchase agreement with the Gates Foundation. Vested or expected to vest (in shares) Represents the number of equity instruments, other than options, that are expected to vest after the balance sheet date. Vested or expected to vest, weighted average grant-date fair value (in dollars per share) Represents the weighted average grant date fair value of equity options, other than options, expected to vest. amrs_CompoundAnnualReturn Compound Annual Return The rate of annual return added on the redemption base price when the Company redeems its stock. Derivative liabilities us-gaap_DerivativeLiabilitiesNoncurrent Vested or expected to vest, weighted average remaining contractual life (Year) Weighted average remaining contractual term for fully vested and expected to vest equity instruments other than options outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. amrs_WorkingCapital Working Capital Represents the difference between the company's current assets and current liabilities. Long-term Debt [Member] Other Area [Member] Represents the other geographic area. Contract liabilities, noncurrent(2) Contract with Customer, Liability, Noncurrent Total Amyris, Inc. stockholders’ deficit us-gaap_StockholdersEquity Total Amyris, Inc. stockholders’ deficit Sale of Subsidiary and Entry Into Commercial Agreements, Policy [Policy Text Block] Disclosure of accounting policy on the sale of subsidiary and entry into commercial agreements. Capital leases, net of current portion Long-term portion Long-term debt, net of current portion us-gaap_LongTermDebtNoncurrent Private Placement February 2016 [Member] Represents the private placement in 2016. Interest Rate Swap [Member] Convertible Promissory Notes [Member] Information related to convertible promissory notes. us-gaap_LiabilitiesForGuaranteesOnLongDurationContractsGuaranteedBenefitLiabilityNet Liabilities for Guarantees on Long-Duration Contracts, Guaranteed Benefit Liability, Net, Ending Balance us-gaap_DerivativeFixedInterestRate Derivative, Fixed Interest Rate Convertible Senior Notes, 9.5% [Member] Represents the 9.5% Convertible Senior Notes. 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Consolidated Statements of Comprehensive Loss - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Comprehensive loss:    
Net loss $ (230,235) $ (155,982)
Foreign currency translation adjustment (1,187) (1,252)
Comprehensive loss attributable to Amyris, Inc. $ (231,422) $ (157,234)
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Note 1 - Basis of Presentation and Summary of Significant Accounting Policies - Adoption of ASC 606 (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Revenues $ 63,604 $ 127,671
Difference between Revenue Guidance in Effect before and after Topic 606 [Member] | Accounting Standards Update 2014-09 [Member]    
Revenues (692)  
Calculated under Revenue Guidance in Effect before Topic 606 [Member]    
Revenues 62,912  
Product [Member]    
Revenues 33,598 42,370
Product [Member] | Difference between Revenue Guidance in Effect before and after Topic 606 [Member] | Accounting Standards Update 2014-09 [Member]    
Revenues  
Product [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member]    
Revenues 33,598  
Licenses and Royalties [Member]    
Revenues 7,658 48,703 [1]
Licenses and Royalties [Member] | Difference between Revenue Guidance in Effect before and after Topic 606 [Member] | Accounting Standards Update 2014-09 [Member]    
Revenues 5,094  
Licenses and Royalties [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member]    
Revenues 12,752  
Grants and Collaborations [Member]    
Revenues 22,348 $ 36,598
Grants and Collaborations [Member] | Difference between Revenue Guidance in Effect before and after Topic 606 [Member] | Accounting Standards Update 2014-09 [Member]    
Revenues (5,786)  
Grants and Collaborations [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member]    
Revenues $ 16,562  
[1] Ginkgo partnership obligation and promissory note issuance recorded as reduction to revenue and correction of errors in recording revenue from non-cash consideration.
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Note 3 - Balance Sheet Details - Allowance for Doubtful Accounts Activity and Balances (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Balance at Beginning of Year $ 642 $ 501
Provisions 141
Balance at End of Year $ 642 $ 642
XML 20 R2.htm IDEA: XBRL DOCUMENT v3.19.3
Consolidated Balance Sheets - USD ($)
$ in Thousands
Dec. 31, 2018
Dec. 31, 2017
Current assets:    
Cash and cash equivalents $ 45,353 $ 57,059
Restricted cash 741 2,994
Accounts receivable, net of allowance of $642 and $619, respectively 16,003 18,953 [1]
Accounts receivable related party, net of allowance of $0 and $23, respectively 1,349 4,767 [1]
Accounts receivable, unbilled - related party 8,021 9,901
Inventories 9,693 5,408
Deferred cost of products sold, current - related party 489
Prepaid expenses and other current assets 10,566 4,919 [2]
Total current assets 92,215 104,001
Property, plant and equipment, net 19,756 13,892
Accounts receivable, unbilled, noncurrent - related party 1,203 7,940
Deferred cost of products sold, noncurrent - related party 2,828
Restricted cash, noncurrent 960 959
Recoverable taxes from Brazilian government entities 3,005 1,445
Other assets 7,958 12,559 [3]
Total assets 127,925 140,796
Current liabilities:    
Accounts payable 26,844 15,515 [4]
Accrued and other current liabilities 28,979 29,202 [5]
Contract liabilities(1) [6],[7] 8,236 4,308 [8]
Debt, current portion (includes instrument measured at fair value of $57,918 and $0, respectively) 124,010 36,924
Related party debt, current portion 23,667 20,019
Total current liabilities 211,736 105,968
Long-term debt, net of current portion 43,331 60,220 [9]
Related party debt, net of current portion 18,689 46,541
Derivative liabilities 42,796 116,497 [10]
Other noncurrent liabilities 23,192 23,658 [11]
Total liabilities 339,744 352,884
Commitments and contingencies (Note 9)
Mezzanine Equity 5,000 5,000
Stockholders’ deficit:    
Preferred stock - $0.0001 par value, 5,000,000 shares authorized as of December 31, 2018 and 2017, and 14,656 and 22,171 shares issued and outstanding as of December 31, 2018 and 2017, respectively
Common stock - $0.0001 par value, 250,000,000 shares authorized as of December 31, 2018 and 2017, respectively; 76,564,829 and 45,637,433 shares issued and outstanding as of December 31, 2018 and 2017, respectively 8 5
Additional paid-in capital 1,346,996 1,114,546 [12]
Accumulated other comprehensive loss (43,343) (42,156)
Accumulated deficit (1,521,417) (1,290,420) [13]
Total Amyris, Inc. stockholders’ deficit (217,756) (218,025)
Noncontrolling interest 937 937
Total stockholders' deficit (216,819) (217,088)
Total liabilities, mezzanine equity and stockholders' deficit $ 127,925 $ 140,796
[1] Reclassification of related party accounts receivable to a separate line on the balance sheet.
[2] Write-off of unrecoverable receivable in connection with facilities subleased to a related party.
[3] Correction of error in recording amounts payable under Ginkgo Partnership Agreement as prepaid royalties instead of reduction in revenue.
[4] Adjustment to uninvoiced receipts liability.
[5] Adjustment to accrued liability.
[6] The balance in contract liabilities at December 31, 2017 represents deferred revenue, current prior to the Company's adoption of ASC 606, "Revenue".
[7] The balance in contract liabilities, current at December 31, 2017 represents deferred revenue, current prior to the Company's adoption of ASC 606, "Revenue".
[8] Revision to accounting for equity received in satisfaction of a customer receivable.
[9] Adjustment to issuance-date fair value of a debt instrument.
[10] Make-whole derivative liabilities adjustment.
[11] Accrual of the Ginkgo Partnership Payments obligation, net of reduction to deferred revenue liability.
[12] Correction to the accounting for a make-whole equity instrument in connection with May 2017 equity offering.
[13] Sum of adjustments to net loss for the year ended December 31, 2017 as result of corrections.
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Note 14 - Income Taxes - Deferred Tax Assets and Liabilities (Details) - USD ($)
$ in Thousands
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Net operating loss carryforwards $ 57,921 $ 20,066  
Property, plant and equipment 9,269 9,653  
Research and development credits 12,046 9,480  
Foreign tax credit  
Accruals and reserves 8,526 7,286  
Stock-based compensation 6,496 5,471  
Disallowed interest carryforward 2,359  
Capitalized start-up costs  
Capitalized research and development costs 27,888 32,085  
Intangible and others 3,114 3,584  
Equity investments 156  
Total deferred tax assets 127,775 87,625  
Debt discount and derivatives (3,750) (6,539)  
Total deferred tax liabilities (3,750) (6,539)  
Net deferred tax assets prior to valuation allowance 124,025 81,086  
Less: valuation allowance (124,025) (81,086) $ (386,867)
Net deferred tax assets  
XML 22 R65.htm IDEA: XBRL DOCUMENT v3.19.3
Note 7 - Stockholders' Deficit - Warrant Activity (Details)
12 Months Ended
Dec. 31, 2018
shares
Number outstanding, beginning balance (in shares) 29,921,844
Additional Warrants Issued (in shares) 17,898,107
Exercises (in shares) (20,928,439)
Number outstanding, ending balance (in shares) 26,891,512
Warrant 6 [Member]  
Number outstanding, beginning balance (in shares)
Additional Warrants Issued (in shares) 12,097,164
Exercises (in shares)
Number outstanding, ending balance (in shares) 12,097,164
Warrant 4 [Member]  
Number outstanding, beginning balance (in shares) 18,042,568
Additional Warrants Issued (in shares)
Exercises (in shares) (11,749,770)
Number outstanding, ending balance (in shares) 6,292,798
Warrant 5 [Member]  
Number outstanding, beginning balance (in shares) 9,543,234
Additional Warrants Issued (in shares) 1,713,565
Exercises (in shares) (7,288,683)
Number outstanding, ending balance (in shares) 3,968,116
Warrant 7 [Member]  
Number outstanding, beginning balance (in shares)
Additional Warrants Issued (in shares) 3,616,174
Exercises (in shares)
Number outstanding, ending balance (in shares) 3,616,174
Warrant 2 [Member]  
Number outstanding, beginning balance (in shares) 2,082,010
Additional Warrants Issued (in shares) 471,204
Exercises (in shares) (1,889,986)
Number outstanding, ending balance (in shares) 663,228
Warrant 3 [Member]  
Number outstanding, beginning balance (in shares) 171,429
Additional Warrants Issued (in shares)
Exercises (in shares)
Number outstanding, ending balance (in shares) 171,429
Warrant 1 [Member]  
Number outstanding, beginning balance (in shares) 81,197
Additional Warrants Issued (in shares)
Exercises (in shares)
Number outstanding, ending balance (in shares) 81,197
Warrant 8 [Member]  
Number outstanding, beginning balance (in shares) 1,406
Additional Warrants Issued (in shares)
Exercises (in shares)
Number outstanding, ending balance (in shares) 1,406
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Note 5 - Debt - Debt Components (Details) - USD ($)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Nov. 30, 2017
Principal $ 228,921,000 $ 195,819,000  
Unamortized Debt Premium (17,142,000) (32,115,000)  
Gain from change in fair value of debt (2,082,000)  
Net 209,697,000 163,704,000  
Net (147,677,000) (56,943,000)  
Net 62,020,000 106,761,000  
Convertible Senior Notes, 6.0% Due in 2021 [Member]      
Principal 60,000,000    
Gain from change in fair value of debt (2,100,000)    
Convertible Debt [Member]      
Principal 126,306,000 70,900,000  
Unamortized Debt Premium (3,350,000) (14,779,000)  
Gain from change in fair value of debt (2,082,000)    
Net 120,874,000 56,121,000  
Convertible Debt [Member] | Convertible Senior Notes, 6.0% Due in 2021 [Member]      
Principal 60,000,000  
Unamortized Debt Premium  
Gain from change in fair value of debt (2,082,000)    
Net 57,918,000  
Convertible Debt [Member] | The 2015 144A Notes [Member]      
Principal 37,887,000 37,887,000  
Unamortized Debt Premium (2,413,000) (9,458,000)  
Gain from change in fair value of debt    
Net 35,474,000 28,429,000  
Convertible Debt [Member] | The 2014 144A Notes [Member]      
Principal 24,004,000 24,004,000  
Unamortized Debt Premium (867,000) (3,170,000)  
Gain from change in fair value of debt    
Net 23,137,000 20,834,000  
Convertible Debt [Member] | August 2013 Convertible Notes [Member]      
Principal 4,415,000 4,009,000  
Unamortized Debt Premium (70,000) (2,126,000)  
Gain from change in fair value of debt    
Net 4,345,000 1,883,000  
Convertible Debt [Member] | December 2017 Convertible Note [Member]      
Principal 5,000,000  
Unamortized Debt Premium (25,000)  
Gain from change in fair value of debt    
Net 4,975,000  
Related Party Convertible Notes [Member]      
Principal 24,705,000 50,116,000  
Unamortized Debt Premium (1,038,000) (2,905,000)  
Gain from change in fair value of debt    
Net 23,667,000 47,211,000  
Related Party Convertible Notes [Member] | The 2014 144A Notes [Member]      
Principal 24,705,000 24,705,000  
Unamortized Debt Premium (1,038,000) (3,784,000)  
Gain from change in fair value of debt    
Net 23,667,000 20,921,000  
Related Party Convertible Notes [Member] | August 2013 Convertible Notes [Member]      
Principal 21,711,000  
Unamortized Debt Premium 897,000  
Gain from change in fair value of debt    
Net 22,608,000  
Related Party Convertible Notes [Member] | Secured R&D Notes [Member]      
Principal 3,700,000  
Unamortized Debt Premium (18,000)  
Gain from change in fair value of debt    
Net 3,682,000  
Nonrelated Party Debt [Member]      
Principal 36,000,000  
Unamortized Debt Premium (1,349,000)  
Gain from change in fair value of debt    
Net 34,651,000  
Loans Payable [Member]      
Principal 52,910,000 47,410,000  
Unamortized Debt Premium (6,443,000) (6,392,000)  
Gain from change in fair value of debt    
Net 46,467,000 41,018,000  
Loans Payable [Member] | Ginkgo Collaboration Note [Member]      
Principal 12,000,000 12,000,000 $ 12,000,000
Unamortized Debt Premium (4,047,000) (4,862,000)  
Gain from change in fair value of debt    
Net 7,953,000 7,138,000  
Loans Payable [Member] | Other Loans Payable [Member]      
Principal 4,910,000 6,463,000  
Unamortized Debt Premium (1,047,000) (1,277,000)  
Gain from change in fair value of debt    
Net 3,863,000 5,186,000  
Loans Payable [Member] | Senior Secured Convertible Note [Member]      
Principal 28,566,000  
Unamortized Debt Premium (253,000)  
Gain from change in fair value of debt    
Net 28,313,000  
Loans Payable [Member] | Other Credit Facilities [Member]      
Principal 381,000  
Unamortized Debt Premium  
Gain from change in fair value of debt    
Net 381,000  
Related Party Loan Payable [Member]      
Principal 25,000,000 27,393,000  
Unamortized Debt Premium (6,311,000) (8,039,000)  
Gain from change in fair value of debt    
Net 18,689,000 19,354,000  
Related Party Loan Payable [Member] | Other Loans Payable [Member]      
Principal 393,000  
Unamortized Debt Premium  
Gain from change in fair value of debt    
Net 393,000  
Related Party Loan Payable [Member] | DSM Note [Member]      
Principal 25,000,000 25,000,000  
Unamortized Debt Premium (6,311,000) (8,039,000)  
Gain from change in fair value of debt    
Net 18,689,000 16,961,000  
Related Party Loan Payable [Member] | Private Placement February 2016 [Member]      
Principal 2,000,000  
Unamortized Debt Premium  
Gain from change in fair value of debt    
Net $ 2,000,000  
XML 24 R91.htm IDEA: XBRL DOCUMENT v3.19.3
Note 14 - Income Taxes (Details Textual) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount $ 42,900 $ 305,800
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent 21.00% 34.00%
Provisional Amount Due to Remeasurement of Deferred Tax Assets and Liabilities, Before Valuation Allowance   $ 37,700
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued, Total $ 0 0
Domestic Tax Authority [Member] | Internal Revenue Service (IRS) [Member]    
Operating Loss Carryforwards, Total $ 290,700  
Operating Loss Carryforwards, Write-off   456,200
Open Tax Year 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018  
Domestic Tax Authority [Member] | Internal Revenue Service (IRS) [Member] | Research Tax Credit Carryforward [Member]    
Tax Credit Carryforward, Write-offs   14,700
Tax Credit Carryforward, Amount $ 1,600  
State and Local Jurisdiction [Member]    
Operating Loss Carryforwards, Total 154,300  
Operating Loss Carryforwards, Write-off   $ 115,500
State and Local Jurisdiction [Member] | California Franchise Tax Board [Member] | Research Tax Credit Carryforward [Member]    
Tax Credit Carryforward, Amount 13,500  
Foreign Tax Authority [Member]    
Operating Loss Carryforwards, Total $ 7,300  
Foreign Tax Authority [Member] | Secretariat of the Federal Revenue Bureau of Brazil [Member]    
Open Tax Year 2010 2011 2012 2013 2014 2015 2016 2017 2018  
XML 25 R69.htm IDEA: XBRL DOCUMENT v3.19.3
Note 9 - Commitments and Contingencies (Details Textual) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Operating Leases, Rent Expense, Total $ 5,800 $ 5,100
Liabilities for Guarantees on Long-Duration Contracts, Guaranteed Benefit Liability, Net, Ending Balance $ 0 $ 0
XML 26 R99.htm IDEA: XBRL DOCUMENT v3.19.3
Note 16 - Subsequent Events (Details Textual)
1 Months Ended 9 Months Ended 12 Months Ended
Sep. 23, 2019
USD ($)
Sep. 19, 2019
USD ($)
Sep. 17, 2019
USD ($)
Sep. 10, 2019
USD ($)
$ / shares
shares
Aug. 19, 2019
Aug. 14, 2019
USD ($)
$ / shares
shares
Aug. 08, 2019
USD ($)
Jul. 30, 2019
USD ($)
Jul. 26, 2019
USD ($)
Jul. 24, 2019
USD ($)
$ / shares
shares
Jul. 08, 2019
shares
Jun. 24, 2019
USD ($)
$ / shares
shares
May 15, 2019
USD ($)
$ / shares
shares
May 14, 2019
USD ($)
$ / shares
shares
May 10, 2019
USD ($)
$ / shares
shares
May 10, 2019
BRL (R$)
shares
May 03, 2019
USD ($)
$ / shares
shares
Apr. 29, 2019
USD ($)
$ / shares
shares
Apr. 26, 2019
USD ($)
$ / shares
shares
Apr. 16, 2019
USD ($)
$ / shares
shares
Apr. 15, 2019
USD ($)
Apr. 04, 2019
USD ($)
Mar. 18, 2019
USD ($)
Aug. 03, 2017
USD ($)
Aug. 31, 2017
USD ($)
May 31, 2017
USD ($)
Jun. 30, 2020
USD ($)
Dec. 31, 2018
USD ($)
shares
Dec. 31, 2017
USD ($)
Sep. 30, 2019
Sep. 16, 2019
USD ($)
Aug. 29, 2019
USD ($)
$ / shares
Aug. 28, 2019
$ / shares
Jul. 29, 2019
USD ($)
Jul. 18, 2019
Jul. 16, 2019
Jul. 10, 2019
USD ($)
$ / shares
Jun. 11, 2019
USD ($)
Apr. 08, 2019
USD ($)
Jan. 14, 2019
USD ($)
Jan. 01, 2019
shares
Dec. 10, 2018
USD ($)
Dec. 06, 2018
USD ($)
Nov. 30, 2018
Aug. 17, 2018
$ / shares
Jun. 29, 2018
USD ($)
Shares, Outstanding, Ending Balance | shares                                                       76,564,829                                    
Long-term Debt, Gross                                                       $ 228,921,000 $ 195,819,000                                  
Proceeds from Issuance of Common Stock                                                       5,759,000                                  
Extinguishment of Debt, Amount                                                   $ 40,200,000                                        
Long-term Debt, Total                                                       $ 209,697,000 163,704,000                                  
July Foris Credit Agreement [Member]                                                                                            
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                                                                                         $ 7.52  
Convertible Senior Notes, 6.0% Due in 2021 [Member]                                                                                            
Debt Instrument, Interest Rate, Stated Percentage                                                       6.00%                           6.00% 6.00%      
Debt Instrument, Face Amount                                                                                   $ 60,000,000 $ 60,000,000      
Long-term Debt, Gross                                                       $ 60,000,000                                    
Great American Capital Partners, LLC [Member] | Loan and Security Agreement [Member]                                                                                            
Debt Instrument, Face Amount                                                                                           $ 36,000,000
Line of Credit Facility, Maximum Borrowing Capacity                                                                                           $ 35,000,000
Great American Capital Partners, LLC [Member] | Loan and Security Agreement [Member] | Minimum [Member]                                                                                            
Debt Instrument, Interest Rate, Stated Percentage                                                       8.25%                               6.25%    
Great American Capital Partners, LLC [Member] | Loan and Security Agreement [Member] | Maximum [Member]                                                                                            
Debt Instrument, Interest Rate, Stated Percentage                                                       9.00%                               8.25%    
DSM International B.V. [Member]                                                                                            
Consideration Transferred                                               $ 34,000,000 $ 34,000,000                                          
Convertible Debt [Member]                                                                                            
Long-term Debt, Gross                                                       $ 126,306,000 70,900,000                                  
Long-term Debt, Total                                                       120,874,000 56,121,000                                  
Convertible Debt [Member] | Convertible Senior Notes, 6.0% Due in 2021 [Member]                                                                                            
Long-term Debt, Gross                                                       60,000,000                                  
Long-term Debt, Total                                                       57,918,000                                  
Convertible Debt [Member] | August 2013 Convertible Notes [Member]                                                                                            
Long-term Debt, Gross                                                       4,415,000 4,009,000                                  
Long-term Debt, Total                                                       $ 4,345,000 $ 1,883,000                                  
Subsequent Event [Member] | Private Placement [Member]                                                                                            
Warrant Exercise, Beneficial Common Stock Ownership Maximum Percentage                                 19.99%                                                          
Proceeds from Issuance of Common Stock                                 $ 5,000,000 $ 5,800,000 $ 23,200,000                                                      
Subsequent Event [Member] | LSA Amendment Warrants [Member]                                                                                            
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares           1,438,829                                                                                
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares           $ 2.87                                                                                
Warrants and Rights Outstanding, Term           2 years                                                                                
Warrant Exercise, Beneficial Common Stock Ownership Maximum Percentage           19.99%                                                                                
Subsequent Event [Member] | July Foris Credit Agreement [Member]                                                                                            
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                                                                         $ 2.87                  
Subsequent Event [Member] | August Foris Credit Agreement [Member]                                                                                            
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares           4,871,795                                                                                
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares           $ 3.90                                                                                
Class of Warrant or Right, Term           2 years                                                                                
Class of Warrant or Right, Stock Ownership Percentage, Restriction on Ability to Exercise           19.99%                                                                                
Subsequent Event [Member] | Warrants Issued for 2014 Rule 144A Convertible Notes Exchanges [Member]                                                                                            
Class of Warrant or Right, Stock Ownership Percentage, Restriction on Ability to Exercise                         4.99%                                                                  
Subsequent Event [Member] | Warrants Issued in Exchange for 6% Convertible Notes Due 2021 [Member]                                                                                            
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares                   2,000,000   181,818 2,000,000                                                                  
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                       $ 5.12 $ 5.12                                                                  
Debt Instrument, Repayment Price, Percent of Face Amount                       4.99% 4.99%                                                                  
Class of Warrant or Right, Term                       2 years 2 years                                                                  
Subsequent Event [Member] | Warrants Issued in Exchange for Convertible Senior Notes, 6.0% Due 2021, Second Exchange [Member]                                                                                            
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares                   2,000,000                                                                        
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                   $ 2.87                                                                        
Class of Warrant or Right, Term                         2 years                                                                  
Subsequent Event [Member] | Warrants Issued in Exchange for August 2013 Financing Convertible Note [Member]                                                                                            
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares                     1,080,000                                                                      
Class of Warrant or Right, Stock Ownership Percentage, Restriction on Ability to Exercise                     4.99%                                                                      
Subsequent Event [Member] | Investor Warrants [Member]                                                                                            
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares       3,205,128                                                                                    
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares       $ 3.90                                                                                    
Warrants and Rights Outstanding, Term       2 years                                                                                    
Warrants or Rights Outstanding, Maximum Percent of Common Stock Outstanding       9.99%                                                                                    
Warrants or Rights Outstanding, Reduction in Exercise Price       10.00%                                                                                    
Warrants or Rights Outstanding, Additional Reduction in Exercise Price       5.00%                                                                                    
Subsequent Event [Member] | Minimum [Member] | Investor Warrants [Member]                                                                                            
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares       $ 3.31                                                                                    
Subsequent Event [Member] | Foris Ventures, LLC [Member]                                                                                            
Related Party Transaction, Purchases from Related Party                                         $ 2,500,000                                                  
Subsequent Event [Member] | Raizen Energia S.A. [Member]                                                                                            
Capital Contribution to the Joint Venture | R$                               R$ 2,500,000                                                            
Equity Method Investment, Ownership Percentage                             50.00%                                                              
Equity Method Investment, Ownership Percentage by Counterparty                             50.00%                                                              
Subsequent Event [Member] | Raizen Energia S.A. [Member] | Fixed Assets Owned by the Company [Member]                                                                                            
Payments to Acquire Property, Plant, and Equipment, Total                             $ 9,000,000                                                              
Subsequent Event [Member] | Raizen Energia S.A. [Member] | Fixed Assets From Sao Martinho S.A. [Member]                                                                                            
Payments to Acquire Property, Plant, and Equipment, Total                             $ 3,000,000                                                              
Subsequent Event [Member] | Loan and Security Agreement Amendment and Waiver [Member]                                                                                            
Debt Instrument, Interest Rate, Stated Percentage         4.75%                                                                                  
Long-term Debt, Gross           $ 71,000,000                                                                                
Subsequent Event [Member] | Loan and Security Agreement Amendment and Waiver [Member] | Base Rate [Member] | Minimum [Member]                                                                                            
Debt Instrument, Basis Spread on Variable Rate         9.00%                                                                                  
Subsequent Event [Member] | Loan and Security Agreement Amendment and Waiver [Member] | Base Rate [Member] | Maximum [Member]                                                                                            
Debt Instrument, Basis Spread on Variable Rate         12.00%                                                                                  
Subsequent Event [Member] | Convertible Senior Notes, 6.0% Due in 2021 [Member]                                                                                            
Debt Instrument, Repayment Price, Percent of Face Amount                 125.00%     125.00% 125.00%                                                                  
Debt Conversion, Original Debt, Amount                 $ 4,700,000 $ 53,300,000   $ 4,700,000 $ 53,300,000                                                                  
Debt Instrument, Penalty for Failure to Make Payment, Premium Increase Percentage                         25.00%                                                                  
Debt Instrument, Periodic Payment, Principal                         $ 6,400,000                                                                  
Subsequent Event [Member] | Convertible Senior Notes, 6.0%, Due in 2021, Second Exchange [Member]                                                                                            
Debt Instrument, Interest Rate, Stated Percentage                   18.00%                                                                        
Debt Instrument, Face Amount                   $ 68,300,000                                                                        
Debt Instrument, Periodic Payment, Principal                   $ 3,200,000                                                                        
Debt Instrument, Debt Default, Amount                                                             $ 63,600,000                              
Subsequent Event [Member] | Nikko Loan Agreement [Member]                                                                                            
Debt Instrument, Interest Rate, Stated Percentage                                                                   5.00%                        
Long-term Debt, Total                                                                   $ 5,000,000                        
Subsequent Event [Member] | Nikko Loan Agreement, First Installment [Member]                                                                                            
Debt Instrument, Face Amount               $ 3,000,000                                                                            
Proceeds from Issuance of Long-term Debt, Total               2,800,000                                                                            
Subsequent Event [Member] | Nikko Loan Agreement, Second Installment [Member]                                                                                            
Debt Instrument, Face Amount             $ 2,000,000                                                                              
Proceeds from Issuance of Long-term Debt, Total             1,900,000                                                                              
Subsequent Event [Member] | The Naxyris Loan Agreement [Member]                                                                                            
Debt Instrument, Interest Rate, Stated Percentage           12.00%                                                                                
Debt Instrument, Face Amount           $ 10,435,000                                                                                
Debt Instrument, Failure to Pay Fee           6.00%                                                                                
Subsequent Event [Member] | The Naxyris Loan Agreement [Member] | Interest Wtih Respect to Indebtedness [Member]                                                                                            
Debt Instrument, Basis Spread on Variable Rate           0.25%                                                                                
Subsequent Event [Member] | The Investor Notes [Member]                                                                                            
Debt Instrument, Interest Rate, Stated Percentage       12.00%                                                                                    
Debt Instrument, Face Amount       $ 12,500,000                                                                                    
Debt Instrument, Early Repayment Amount, Percentage       100.00%                                                                                    
Subsequent Event [Member] | Great American Capital Partners, LLC [Member] | Loan and Security Agreement [Member]                                                                                            
Debt Instrument, Requirement, Unrestricted, Unencumbered Cash                                           $ 15,000,000                                                
Payments for debt agreement amendment                                           $ 800,000                                                
Subsequent Event [Member] | Foris Ventures, LLC [Member] | April Foris Credit Agreement [Member]                                                                                            
Debt Instrument, Interest Rate, Stated Percentage                                                                             0.00%              
Debt Instrument, Face Amount                                                                             $ 8,000,000              
Line of Credit Facility, Maximum Borrowing Capacity                                                                             8,000,000              
Subsequent Event [Member] | Foris Ventures, LLC [Member] | April Foris Credit Agreement [Member] | Minimum [Member]                                                                                            
Debt Instrument, Fee Amount                                                                             1,000,000              
Subsequent Event [Member] | Foris Ventures, LLC [Member] | April Foris Credit Agreement [Member] | Maximum [Member]                                                                                            
Debt Instrument, Fee Amount                                                                             $ 500,000              
Subsequent Event [Member] | Foris Ventures, LLC [Member] | June Foris Credit Agreement [Member]                                                                                            
Debt Instrument, Interest Rate, Stated Percentage                                                                           12.50%                
Debt Instrument, Face Amount                                                                           $ 8,500,000                
Line of Credit Facility, Maximum Borrowing Capacity                                                                           $ 8,500,000                
Subsequent Event [Member] | Foris Ventures, LLC [Member] | July Foris Credit Agreement [Member]                                                                                            
Debt Instrument, Interest Rate, Stated Percentage                 12.50%                                                       12.50%                  
Debt Instrument, Face Amount                 $ 8,000,000                                                       $ 8,000,000                  
Line of Credit Facility, Maximum Borrowing Capacity                                                                         16,000,000                  
Long-term Line of Credit, Total                 $ 8,000,000                                                       $ 8,000,000                  
Subsequent Event [Member] | Foris Ventures, LLC [Member] | Foris Credit Agreements [Member]                                                                                            
Debt Instrument, Repayment Price, Percent of Face Amount                                                           100.00%                                
Subsequent Event [Member] | Foris Ventures, LLC [Member] | August Foris Credit Agreement [Member]                                                                                            
Debt Instrument, Interest Rate, Stated Percentage                                                               12.00%                            
Debt Instrument, Face Amount                                                               $ 19,000,000                            
Line of Credit Facility, Maximum Borrowing Capacity                                                               $ 19,000,000                            
Debt Instrument, Repayment Price, Percent of Face Amount                                                           100.00%                                
Subsequent Event [Member] | DSM International B.V. [Member] | The 2019 DSM Credit Agreement [Member]                                                                                            
Line of Credit Facility, Maximum Borrowing Capacity     $ 8,000,000                                                                                      
Debt Instrument, Repayment Price, Percent of Face Amount     100.00%                                                                                      
Proceeds from Sale of Equity Securities, Gross, Trigger Repayment of Amounts Outstanding Under Line of Credit                                                     $ 50,000,000                                      
Subsequent Event [Member] | DSM International B.V. [Member] | The 2019 DSM Credit Agreement, First Installment [Member]                                                                                            
Debt Instrument, Interest Rate, Stated Percentage     12.50%                                                                                      
Debt Instrument, Face Amount     $ 3,000,000                                                                                      
Extinguishment of Debt, Amount     3,000,000                                                                                      
Line of Credit Facility, Incremental Draw Down Amount     $ 3,000,000                                                                                      
Subsequent Event [Member] | DSM International B.V. [Member] | The 2019 DSM Credit Agreement, Second Installment [Member]                                                                                            
Debt Instrument, Interest Rate, Stated Percentage   12.50%                                                                                        
Debt Instrument, Face Amount   $ 3,000,000                                                                                        
Extinguishment of Debt, Amount   3,000,000                                                                                        
Line of Credit Facility, Incremental Draw Down Amount   $ 3,000,000                                                                                        
Subsequent Event [Member] | DSM International B.V. [Member] | The 2019 DSM Credit Agreement, Third Installment [Member]                                                                                            
Debt Instrument, Interest Rate, Stated Percentage 12.50%                                                                                          
Debt Instrument, Face Amount $ 2,000,000                                                                                          
Extinguishment of Debt, Amount 1,500,000                                                                                          
Line of Credit Facility, Incremental Draw Down Amount $ 2,000,000                                                                                          
Subsequent Event [Member] | The Investors [Member]                                                                                            
Line of Credit Facility, Maximum Borrowing Capacity       $ 12,500,000                                                                                    
Subsequent Event [Member] | Foris Ventures, LLC [Member] | Private Placement [Member]                                                                                            
Stock Issued During Period, Shares, New Issues | shares                                     2,832,440 6,732,369                                                    
Shares Issued, Price Per Share | $ / shares                                     $ 5.12 $ 2.87                                                    
Proceeds from Issuance of Common Stock                                       $ 20,000,000                                                    
Subsequent Event [Member] | Foris Ventures, LLC [Member] | Private Placement, April 16, 2019 [Member]                                                                                            
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares                                       5,424,804                                                    
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                                       $ 2.87                                                    
Class of Warrant or Right, Term                                       2 years                                                    
Subsequent Event [Member] | Foris Ventures, LLC [Member] | Private Placement, April 26, 2019 [Member]                                                                                            
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares                                     3,983,230                                                      
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                                     $ 5.12                         $ 3.90                            
Class of Warrant or Right, Term                                     2 years                                                      
Subsequent Event [Member] | Foris Ventures, LLC [Member] | Warrants Issued for 2014 Rule 144A Convertible Notes Exchanges [Member]                                                                                            
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                           $ 4.56                                     $ 3.90                          
Class of Warrant or Right, Term                           2 years                                                                
Debt Conversion, Converted Instrument, Warrants Issued | shares                           352,638                                                                
Subsequent Event [Member] | Foris Ventures, LLC [Member] | Rule 144A Convertible Notes [Member]                                                                                            
Debt Conversion, Original Debt, Amount                           $ 5,000,000                                                                
Debt Conversion, Converted Instrument, Shares Issued | shares                           1,122,460                                                                
Subsequent Event [Member] | Other Non-affiliated Investors [Member] | Private Placement [Member]                                                                                            
Stock Issued During Period, Shares, New Issues | shares                                 1,243,781 323,382 2,043,781                                                      
Shares Issued, Price Per Share | $ / shares                                 $ 4.02 $ 4.02 $ 4.02                                                      
Subsequent Event [Member] | Other Non-affiliated Investors [Member] | Private Placement, April 26, 2019 [Member]                                                                                            
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares                                     1,635,025                                                      
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                                     $ 5.02                                                      
Warrants and Rights Outstanding, Term                                     2 years                                                      
Subsequent Event [Member] | Other Non-affiliated Investors [Member] | Private Placement April 29, 2019 [Member]                                                                                            
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares                                   258,704                                                        
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                                   $ 5.02                                                        
Warrants and Rights Outstanding, Term                                   2 years                                                        
Subsequent Event [Member] | Other Non-affiliated Investors [Member] | Private Placement May 3, 2019 [Member]                                                                                            
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares                                 995,024                                                          
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                                 $ 5.02                                                          
Warrants and Rights Outstanding, Term                                 2 years                                                          
Subsequent Event [Member] | Other Non-affiliated Investors [Member] | Warrants Issued for 2014 Rule 144A Convertible Notes Exchanges [Member]                                                                                            
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                             $ 5.02                                                              
Class of Warrant or Right, Term                             2 years 2 years                                                            
Debt Conversion, Converted Instrument, Warrants Issued | shares                             1,391,603 1,391,603                                                            
Subsequent Event [Member] | Other Non-affiliated Investors [Member] | Rule 144A Convertible Notes [Member]                                                                                            
Debt Conversion, Original Debt, Amount                             $ 13,500,000                                                              
Debt Conversion, Converted Instrument, Shares Issued | shares                             3,479,008 3,479,008                                                            
Subsequent Event [Member] | Vivo Capital LLC [Member] | Private Placement [Member]                                                                                            
Stock Issued During Period, Shares, New Issues | shares                                   913,529                                                        
Shares Issued, Price Per Share | $ / shares                                   $ 4.76                                                        
Subsequent Event [Member] | Vivo Capital LLC [Member] | Private Placement April 29, 2019 [Member]                                                                                            
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares                                   1,212,787                                                        
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                                   $ 4.76                                                        
Warrants and Rights Outstanding, Term                                   2 years                                                        
Subsequent Event [Member] | DSM International B.V. [Member]                                                                                            
Consideration Transferred                                       $ 57,000,000                                                    
Consideration Transferred, Cash Amount                                       29,100,000                                                    
Extinguishment of Debt, Amount                                       $ 27,900,000                                                    
Subsequent Event [Member] | Maxwell (Mauritius) Pte Ltd [Member] | Rule 144A Convertible Notes [Member]                                                                                            
Debt Conversion, Original Debt, Amount                         $ 10,000,000                                                                  
Debt Conversion, Converted Instrument, Shares Issued | shares                         2,500,000                                                                  
Subsequent Event [Member] | Total [Member] | Rule 144A Convertible Notes [Member]                                                                                            
Debt Conversion, Original Debt, Amount                         $ 9,700,000                                                                  
Subsequent Event [Member] | Total [Member] | Convertible Senior Notes, 10.5% [Member]                                                                                            
Debt Instrument, Interest Rate, Stated Percentage                                                                 12.00%   10.50%                      
Subsequent Event [Member] | Nikko [Member] | Nikko Loan Agreement [Member] | Aprinnova JV [Member]                                                                                            
First Priority Lien on Interests Owned by the Company                                                                   12.80%                        
Subsequent Event [Member] | Nikko [Member] | Nikko Loan Agreement, First Installment [Member]                                                                                            
Proceeds from Issuance of Long-term Debt, Withheld as Prepayment of Interest Payable               $ 200,000                                                                            
Subsequent Event [Member] | Nikko [Member] | Nikko Loan Agreement, Second Installment [Member]                                                                                            
Proceeds from Issuance of Long-term Debt, Withheld as Prepayment of Interest Payable             $ 100,000                                                                              
Subsequent Event [Member] | The Cannabinoid Agreement [Member] | Lavvan [Member]                                                                                            
Agreement Amount                                             $ 300,000,000                                              
Agreement, Amount of Research and Development Funding that Could Be Received                                             $ 300,000,000                                              
Agreement, Profit Sharing to Be Received from the Counterparty, Period                                             20 years                                              
Subsequent Event [Member] | Equity Incentive Plan, 2010 [Member]                                                                                            
Automatic Annual Increase in the Number of Shares Available for Grant and Issuance | shares                                                                                 3,828,241          
Automatic Annual Increase in Shares Available for Grant and Issuance, Percentage of Outstanding Stock                                                                                 5.00%          
Automatic Annual Increase in the Number of Shares Reserved for Issuance | shares                                                                                 382,824          
Automatic Annual Increase in Shares Reserved for Issuance, Percentage of Outstanding Stock | shares                                                                                 0.5          
Subsequent Event [Member] | Tranche II Notes [Member]                                                                                            
Debt Instrument, Cash Waiver Fee Amount Payable                                                                               $ 600,000            
Debt Instrument, Interest Rate, Stated Percentage                                                                       1.75%                    
Subsequent Event [Member] | Unsecured Promissory Note [Member] | Loan and Security Agreement Amendment and Waiver [Member]                                                                                            
Debt Instrument, Face Amount           $ 32,500,000                                                                                
Subsequent Event [Member] | Convertible Debt [Member] | August 2013 Convertible Notes [Member]                                                                                            
Debt Conversion, Converted Instrument, Shares Issued | shares                     1,767,632                                                                      
Debt Conversion, Converted Instrument, Warrants or Options Issued | shares                     1                                                                      
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XML 30 R23.htm IDEA: XBRL DOCUMENT v3.19.3
Note 14 - Income Taxes
12 Months Ended
Dec. 31, 2018
Notes to Financial Statements  
Income Tax Disclosure [Text Block]
14.
Income Taxes
 
The components of loss before income taxes are as follows:
 
Years Ended December 31,
(In thousands)
  2018   2017
        (As Restated, Note 2)
United States   $
(218,109
)   $
(156,020
)
Foreign    
(12,125
)    
6,915
 
Loss before income taxes   $
(230,234
)   $
(149,105
)
 
The components of the provision for income taxes are as follows:
 
Years Ended December 31,
(In thousands)
  2018   2017
             
(As Restated, Note 2)
 
Current:                
Federal   $
    $
6,564
 
State    
     
18
 
Foreign    
     
964
 
Total current provision    
     
7,546
 
Deferred:                
Federal    
     
(669
)
State    
     
 
Foreign    
     
 
Total deferred benefit    
     
(669
)
Total provision for income taxes$   $
    $
6,877
 
 
A reconciliation between the statutory federal income tax and the Company’s effective tax rates as a percentage of loss before income taxes is as follows:
 
Years Ended December 31,
  2018   2017
        (As Restated, Note 2)
Statutory tax rate    
(21.0
)%    
(34.0
)%
State taxes, net of federal tax benefit    
%    
%
Stock-based compensation    
%    
%
Federal R&D credit    
(0.6
)%    
(0.2
)%
Derivative liability    
4.3
%    
13.9
%
Nondeductible interest    
1.0
%    
3.0
%
Other    
(0.1
)%    
(0.2
)%
Foreign losses    
0.9
%    
8.5
%
Change in U.S. federal tax rate    
%    
25.1
%
IRC Section 382 limitation    
%    
7.2
%
Change in valuation allowance    
15.5
%    
(18.6
)%
Effective income tax rate    
%    
4.7
%
 
Temporary differences and carryforwards that gave rise to significant portions of deferred taxes are as follows:
 
December 31,
(In thousands)
  2018   2017
        (As Restated, Note 2)
Net operating loss carryforwards   $
57,921
    $
20,066
 
Property, plant and equipment    
9,269
     
9,653
 
Research and development credits    
12,046
     
9,480
 
Foreign tax credit    
     
 
Accruals and reserves    
8,526
     
7,286
 
Stock-based compensation    
6,496
     
5,471
 
Disallowed interest carryforward    
2,359
     
 
Capitalized start-up costs    
     
 
Capitalized research and development costs    
27,888
     
32,085
 
Intangible and others    
3,114
     
3,584
 
Equity investments    
156
     
 
Total deferred tax assets    
127,775
     
87,625
 
Debt discount and derivatives    
(3,750
)    
(6,539
)
Total deferred tax liabilities    
(3,750
)    
(6,539
)
Net deferred tax assets prior to valuation allowance    
124,025
     
81,086
 
Less: valuation allowance    
(124,025
)    
(81,086
)
Net deferred tax assets   $
    $
 
 
Activity in the deferred tax assets valuation allowance is summarized as follows:
 
(In thousands)
  Balance at Beginning
of Year
  Additions   Reductions /
Charges
  Balance at
End of Year
Deferred tax assets valuation allowance:                                
Year Ended December 31, 2018   $
81,086
    $
42,939
    $
    $
124,025
 
Year Ended December 31, 2017 (As Restated, Note 2)   $
386,867
    $
    $
(305,781
)   $
81,086
 
 
Recognition of deferred tax assets is appropriate when realization of such assets is more likely than
not.
Based on the weight of available evidence, especially the uncertainties surrounding the realization of deferred tax assets through future taxable income, the Company believes that it is more likely than
not
that the net deferred tax assets will
not
be fully realizable. Accordingly, the Company has provided a full valuation allowance against its net deferred tax assets as of
December 31, 2018
and
2017.
The valuation allowance decreased by
$305.8
million during the year ended
December 31, 2017
and increased by
$42.9
million during the year ended
December 31, 2018.
The valuation allowance decreased by
$305.8
million during the year ended
December 31, 2017
due to the partial write-off of federal net operating loss (NOL) carryforwards due to the IRC Section
382
limitation further described below and due to tax reform that changed deferred tax asset rate from
35%
down to
21%.
 
On
December 22, 2017,
the U.S. government enacted comprehensive tax legislation, commonly referred to as the Tax Cuts and Jobs Act (Tax Act). The Tax Act makes broad and complex changes to the U.S. tax code, including, but
not
limited to, (
1
) reducing the U.S. federal corporate tax rate from
35
percent to
21
percent; (
2
) requiring companies to pay a
one
-time transition tax on certain unrepatriated earnings of foreign subsidiaries; (
3
) generally eliminating U.S. federal income taxes on dividends from foreign subsidiaries; (
4
) requiring a current inclusion in U.S. federal taxable income of certain earnings of controlled foreign corporations; (
5
) eliminating the corporate alternative minimum tax (AMT) and changing how existing AMT credits can be realized; (
6
) creating the base erosion anti-abuse tax, a new minimum tax; (
7
) creating a new limitation on deductible interest expense; and (
8
) changing the rules related to uses and limitations of NOL carryforwards created in tax years beginning after
December 31, 2017.
 
On
December 22, 2017,
Staff Accounting Bulletin
No.
118
(SAB
118
) was issued to address the application of GAAP in situations when a registrant does
not
have the necessary information available, prepared or analyzed (including computations) in reasonable detail to complete the accounting for certain income tax effects of the Tax Act. In accordance with SAB
118,
the Company recorded a provisional amount related to the remeasurement of certain deferred tax assets and liabilities based on the rates at which they are expected to reverse in the future, which resulted in a
$37.7
million net decrease related to deferred tax assets and deferred tax liabilities, with a corresponding and fully offsetting adjustment to our valuation allowance for the year ended
December 31, 2017.
As of
December 22, 2018,
the Company completed its accounting for the remeasurement of certain deferred tax assets and liabilities based on the rates at which they are expected to reverse in the future. There have been
no
net benefit changes to the provisional estimates disclosed in the period of enactment under SAB
118.
The Tax Act also created a new requirement that certain income (i.e., GILTI) earned by controlled foreign corporations (CFCs) must be included currently in the gross income of the CFCs' U.S. shareholder. The Company has elected to treat GILTI as a period cost in its income tax provision computations.
 
As of
December 31, 2018,
the Company had federal net operating loss carryforwards of approximately
$290.7
million and state net operating loss carryforwards
$154.3
million, available to reduce future taxable income, if any. The Internal Revenue Code of
1986,
as amended, imposes restrictions on the utilization of net operating losses in the event of an “ownership change” of a corporation. Accordingly, a company’s ability to use net operating losses
may
be limited as prescribed under Internal Revenue Code Section
382
(IRC Section
382
). Events that
may
cause limitations in the amount of the net operating losses that the Company
may
use in any
one
year include, but are
not
limited to, a cumulative ownership change of more than
50%
over a
three
-year period. During the year ended
December 31, 2017,
the Company experienced a cumulative ownership change of greater than
50%.
As such, net operating losses generated prior to that change are subject to an annual limitation on their use. Due to the limitations imposed, the Company wrote-off
$456.2
million and
$115.5
million of federal NOL and state NOL carryovers that are expected to expire before they can be utilized. Additionally, the Company wrote-off
$14.7
million of its historical federal research and development credit carryovers as a result of the limitations. As of
December 31, 2018,
the Company had foreign net operating loss carryovers of
$7.3
million.
  
As of
December 31, 2018,
the Company had federal research and development credit carryforwards of
$1.6
million and California research and development credit carryforwards of
$13.5
million.
 
If
not
utilized, the federal net operating loss carryforward will begin expiring in
2025,
and the California net operating loss carryforward will begin expiring in
2028.
The federal research and development credit carryforwards will expire starting in
2038
if
not
utilized. The California research and development credit carryforwards can be carried forward indefinitely.
 
A reconciliation of the beginning and ending amounts of unrecognized tax benefits is as follows:
 
 
(In thousands)
   
Balance at December 31, 2016   $
9,101
 
Increases in tax positions for prior period    
50
 
Increases in tax positions during current period    
19,682
 
Balance at December 31, 2017    
28,833
 
Increases in tax positions for prior period    
55
 
Increases in tax positions during current period    
1,239
 
Balance at December 31, 2018   $
30,127
 
 
The Company’s policy is to include interest and penalties related to unrecognized tax benefits within the provision for taxes. The Company determined that accrual for interest and penalties was
not
material as of
December 31, 2018
or
2017.
 
None
of the unrecognized tax benefits, if recognized, would affect the effective income tax rate for any of the above years due to the valuation allowance that currently offsets deferred tax assets. The Company does
not
anticipate that the total amount of unrecognized income tax benefits will significantly increase or decrease in the next
12
months.
 
The Company’s primary tax jurisdiction is the United States. For United States federal and state tax purposes, returns for tax years
2005
and forward remain open and subject to tax examination by the appropriate federal or state taxing authorities. Brazil tax years
2010
and forward remain open and subject to examination.
 
As of
December 31, 2018,
the U.S. Internal Revenue Service (the IRS) has completed its audit of the Company for tax year
2008
and concluded that there were
no
adjustments resulting from the audit. While the statutes are closed for tax year
2008,
the U.S. federal tax carryforwards (net operating losses and tax credits)
may
be adjusted by the IRS in the year in which the carryforward is utilized.
XML 31 R15.htm IDEA: XBRL DOCUMENT v3.19.3
Note 6 - Mezzanine Equity
12 Months Ended
Dec. 31, 2018
Notes to Financial Statements  
Mezzanine Equity Disclosure [Text Block]
6.
Mezzanine Equity
 
Mezzanine equity at
December 
31,
2018
and
2017
is comprised of proceeds from common shares sold on
May 10, 2016
to the Bill & Melinda Gates Foundation (the Gates Foundation). On
April 8, 2016,
the Company entered into a Securities Purchase Agreement with the Gates Foundation, pursuant to which the Company agreed to sell and issue
292,398
shares of its common stock to the Gates Foundation in a private placement at a purchase price per share of
$17.10,
the average of the daily closing price per share of the Company’s common stock on the Nasdaq Stock Market for the
twenty
consecutive trading days ending on
April 
7,
2016,
for aggregate proceeds to the Company of approximately
$5.0
million (the Gates Foundation Investment). The Securities Purchase Agreement includes customary representations, warranties and covenants of the parties.
 
In connection with the entry into the Securities Purchase Agreement, on
April 
8,
2016,
the Company and the Gates Foundation entered into a Charitable Purposes Letter Agreement, pursuant to which the Company agreed to expend an aggregate amount
not
less than the amount of the Gates Foundation Investment to develop a yeast strain that produces artemisinic acid and/or amorphadiene at a low cost and to supply such artemisinic acid and amorphadiene to companies qualified to convert artemisinic acid and amorphadiene to artemisinin for inclusion in artemisinin combination therapies used to treat malaria commencing in
2017.
The Company is currently conducting the project. If the Company defaults in its obligation to use the proceeds from the Gates Foundation Investment as set forth above or defaults under certain other commitments in the Charitable Purposes Letter Agreement, the Gates Foundation will have the right to request that the Company redeem, or facilitate the purchase by a
third
party of, the Gates Foundation Investment shares then held by the Gates Foundation at a price per share equal to the greater of (i) the closing price of the Company’s common stock on the trading day prior to the redemption or purchase, as applicable, or (ii) an amount equal to
$17.10
plus a compounded annual return of
10%.
As of
December 
31,
2018,
the Company's remaining research and development obligation under this arrangement was
$0.7
million.
XML 32 R11.htm IDEA: XBRL DOCUMENT v3.19.3
Note 2 - Restatement of Consolidated Financial Statements
12 Months Ended
Dec. 31, 2018
Notes to Financial Statements  
Accounting Changes and Error Corrections [Text Block]
2.
Restatement of Consolidated Financial Statements
 
Restatement Background
 
Subsequent to the issuance of the Company's unaudited condensed consolidated financial statements as of
September 30, 2018
and as previously announced on
April 5, 2019
and
May 14, 2019,
the Audit Committee (the Audit Committee) of the Board of Directors of the Company (the Board) and the Board, respectively, concluded that the Company will restate its interim condensed consolidated financial statements for the quarterly and year-to-date periods ended
March 31, 2018,
June 30, 2018
and
September 30, 2018 (
collectively, the Restated
2018
Non-Reliance Periods) and its audited consolidated financial statements for the year ended
December 31, 2017 (
the Restated
2017
Non-Reliance Consolidated Financial Statements).
 
Restated
2017
Non-Reliance Consolidated Financial Statements
 
During the course of the re-audit of the Restated
2017
Financial Statements, in addition to incorrectly accounting for certain payment obligations under the Ginkgo Partnership Agreement as previously disclosed, the Company identified other accounting and financial reporting errors related to (i) the recognition of certain deemed dividends to preferred stock holders, (ii) incorrect accounting treatment for the derecognition of certain debt and derivative liability instruments, (iii) errors in computing tax expense, (iv) incorrect revenue recognition for certain non-cash consideration received under a collaboration agreement, (v) the timing of certain revenue recognition between quarters within
2017,
(vi) computation of earnings (loss) per share, (vii) correction of errors in cash flow statements for non-cash adjustments, and (viii) computation of loss on extinguishment of certain debt instruments.
 
The error corrections for the year to date audited
2017
consolidated financial statements have been reflected throughout these consolidated financial statements and accompanying notes. Also, the tables below show the impact of each adjustment by the individual financial statement line item caption and provide a brief description of the adjustment.
 
Consolidated Balance Sheet
 
The following table presents the Company's consolidated balance sheet at
December 31, 2017
as previously reported, restatement adjustments and as restated (in thousands):
    December 31, 2017  
(In thousands)   As Previously Reported     Corrections     Ref.   As Restated  
Assets                      
Current assets:                            
Cash and cash equivalents   $
57,059
    $
—  
   
 
  $
57,059
 
Restricted cash    
2,994
     
—  
   
 
   
2,994
 
Accounts receivable, net    
24,281
     
(5,328
)  
a
   
18,953
 
Accounts receivable - related party, net    
9,340
     
(4,573
)  
a
   
4,767
 
Accounts receivable, unbilled - related party    
     
9,901
   
 
   
9,901
 
Inventories    
5,408
     
—  
   
 
   
5,408
 
Prepaid expenses and other current assets    
5,525
     
(606
)  
b
   
4,919
 
Total current assets    
104,607
     
(606
)  
 
   
104,001
 
Property, plant and equipment, net    
13,892
     
—  
   
 
   
13,892
 
Accounts receivable, unbilled, noncurrent – related party    
7,940
     
—  
   
 
   
7,940
 
Restricted cash, noncurrent    
959
     
—  
   
 
   
959
 
Recoverable taxes from Brazilian government entities    
1,445
     
—  
   
 
   
1,445
 
Other assets    
22,640
     
(10,081
)  
c
   
12,559
 
Total assets   $
151,483
    $
(10,687
)  
 
  $
140,796
 
Liabilities, Mezzanine Equity and Stockholders' Deficit                            
Current liabilities:                            
Accounts payable   $
15,921
    $
(406
)  
d
  $
15,515
 
Accrued and other current liabilities    
29,402
     
(200
)  
e
   
29,202
 
Contract liabilities    
4,880
     
(572
)  
f
   
4,308
 
Debt, current portion    
36,924
     
—  
   
 
   
36,924
 
Related party debt, current portion    
20,019
     
—  
   
 
   
20,019
 
Total current liabilities    
107,146
     
(1,178
)  
 
   
105,968
 
Long-term debt, net of current portion    
61,893
     
(1,673
)  
g
   
60,220
 
Related party debt, net of current portion    
46,541
     
—  
   
 
   
46,541
 
Derivative liabilities    
119,978
     
(3,481
)  
h
   
116,497
 
Other noncurrent liabilities    
10,632
     
13,026
   
i
   
23,658
 
Total liabilities    
346,190
     
6,694
   
 
   
352,884
 
Commitments and contingencies                            
Mezzanine equity:                            
Contingently redeemable common stock    
5,000
     
—  
   
 
   
5,000
 
Stockholders’ deficit:                            
Preferred stock    
—  
     
—  
   
 
   
—  
 
Common stock - $0.0001 par value    
5
     
—  
   
 
   
5
 
Additional paid-in capital    
1,048,274
     
66,272
   
j
   
1,114,546
 
Accumulated other comprehensive loss    
(42,156
)    
—  
   
 
   
(42,156
)
Accumulated deficit    
(1,206,767
)    
(83,653
)  
k
   
(1,290,420
)
Total Amyris, Inc. stockholders’ deficit    
(200,644
)    
(17,381
)  
 
   
(218,025
)
Noncontrolling interest    
937
     
—  
   
 
   
937
 
Total stockholders' deficit    
(199,707
)    
(17,381
)  
 
   
(217,088
)
Total liabilities, mezzanine equity and stockholders' deficit   $
151,483
    $
(10,687
)  
 
  $
140,796
 
 
Restatement adjustments:
a. Reclassification of related party accounts receivable to a separate line on the balance sheet.
b. Write-off of unrecoverable receivable in connection with facilities subleased to a related party.
c. Correction of error in recording amounts payable under Ginkgo Partnership Agreement as prepaid royalties instead of reduction in revenue.
d. Adjustment to uninvoiced receipts liability.
e. Adjustment to accrued liability.
f. Revision to accounting for equity received in satisfaction of a customer receivable.
g. Adjustment to issuance-date fair value of a debt instrument.
h. Make-whole derivative liabilities adjustment.
i. Accrual of the Ginkgo Partnership Payments obligation, net of reduction to deferred revenue liability.
j. Correction to the accounting for a make-whole equity instrument in connection with
May 2017
equity offering.
k. Sum of adjustments to net loss for the year ended
December 31, 2017
as result of corrections.
 
Consolidated Statement of Operations
 
The following table presents the Company's consolidated statements of operations for the year ended
December 31, 2017
as previously reported, restatement adjustments and as restated (in thousands, except per share amounts):
 
  Year Ended
December 31, 2017
(In thousands, except shares and per share amounts)   As Previously Reported  
Reclassifications
(1)
  Corrections   Ref   As Restated
                     
                     
Renewable products   $
45,781
    $
(3,411
)   $
   
 
  $
42,370
 
Licenses and royalties    
57,703
     
6,774
     
(15,774
)  
ab
   
48,703
 
Grants and collaborations    
39,960
     
(3,363
)    
1
       
36,598
 
Total revenue    
143,444
     
     
(15,773
)  
 
   
127,671
 
Cost and operating expenses    
 
     
     
 
   
 
   
 
 
Cost of products sold    
62,713
     
     
(406
)  
ad
   
62,307
 
Research and development    
57,027
     
(72
)    
607
   
ae
   
57,562
 
Sales, general and administrative    
63,219
     
72
     
562
   
af
   
63,853
 
Total cost and operating expenses    
182,959
     
     
763
   
 
   
183,722
 
Loss from operations    
(39,515
)    
     
(16,536
)  
 
   
(56,051
)
Other income (expense)                                    
(Loss) gain on divestiture    
5,732
     
     
   
 
   
5,732
 
Interest expense    
(34,033
)    
     
(3,048
)  
ah
   
(37,081
)
(Loss) gain from change in fair value of derivative instruments    
(1,742
)    
     
(47,110
)  
ai
   
(48,852
)
Loss upon extinguishment of debt    
(1,521
)    
     
(10,376
)  
ak
   
(11,897
)
Other income (expense), net    
(955
)    
     
(1
)  
 
   
(956
)
Total other expense, net    
(32,519
)    
     
(60,535
)  
 
   
(93,054
)
Loss before income taxes    
(72,034
)    
     
(77,071
)  
 
   
(149,105
)
Provision for income taxes    
(295
)    
     
(6,582
)  
am
   
(6,877
)
Net loss attributable to Amyris, Inc.    
(72,329
)    
     
(83,653
)  
 
   
(155,982
)
Less deemed dividend on capital distribution to related parties    
(8,648
)    
     
8,648
   
an
   
 
Less deemed dividend related to beneficial conversion feature on Series A preferred stock    
(562
)    
     
   
 
   
(562
)
Less deemed dividend related to beneficial conversion feature on Series B preferred stock    
(634
)    
     
   
 
   
(634
)
Less deemed dividend related to beneficial conversion feature on Series D preferred stock    
(5,757
)    
     
   
 
   
(5,757
)
Less deemed dividend upon settlement of make-whole provision on Series A preferred stock    
     
     
(10,505
)  
ap
   
(10,505
)
Less deemed dividend upon settlement of make-whole provision on Series B preferred stock    
     
     
(22,632
)  
aq
   
(22,632
)
Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series A preferred stock    
     
     
(21,578
)  
ar
   
(21,578
)
Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series B preferred stock    
     
     
(24,366
)  
as
   
(24,366
)
Less cumulative dividends on Series A and Series B preferred stock    
(5,439
)    
     
5,439
   
aw
   
 
Add: losses allocated to participating securities    
     
     
40,159
   
au
   
40,159
 
Net loss attributable to Amyris, Inc. common stockholders   $
(93,369
)    
    $
(108,488
)  
 
  $
(201,857
)
                                     
Net loss per share attributable to common stockholders                                    
Basic and diluted   $
(2.89
)    
 
     
 
   
 
  $
(6.26
)
Weighted-average shares of common stock outstanding used in computing loss per share of common stock:                                    
Basic and diluted    
32,253,570
     
 
     
 
   
 
   
32,253,570
 
 
(
1
) Reclassification of revenue and operating expense by type to conform to the Company's current presentation.
 
Restatement adjustments:
ab. Ginkgo partnership obligation and promissory note issuance recorded as reduction to revenue and correction of errors in recording revenue from non-cash consideration.
ad. Correction in connection with a sales return, and adjustment to uninvoiced receipts liability.
ae. Write-off of unrecoverable receivable in connection with facilities subleased to a related party, and reclassification of operating expense by classification to conform to the Company's current presentation.
af. Expense incurred in connection with
May 2017
equity offering.
ah. Correction to amortization of debt discounts, and interest expense in connection with partnership payments obligation.
ai. Correction to accounting for make-whole liability in connection with
May 2017
Offering.
ak. Loss on extinguishment of related and unrelated party debt.
am. Tax provision to accrue liability for unrecognized tax benefit.
an. Loss on extinguishment of related and unrelated party debt.
ap. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings.
aq. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings.
ar. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings.
as. Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings.
au. Correction in the computation of loss per share to reflect participating securities.
aw. Correction in the computation of net loss per share related to make-whole deemed dividends.
 
Consolidated Statement of Cash Flows
 
The following table presents the Company's consolidated statements of cash flows for the year ended
December 31, 2017
as previously reported, restatement adjustments and as restated (in thousands). In this table, As Restated amounts reflect the impact of corrections to the consolidated balance sheet as of
December 31, 2017
and the statement of operations for the year ended
December 31, 2017,
as well as the Company's adoption of ASU
2016
-
18,
which changes how restricted cash is reported in statements of cash flows.
 
    Year Ended December 31, 2017
(In thousands)
  As Previously Reported   Corrections
(1)
  As Restated
             
Operating activities                        
Net loss   $
(72,329
)    
(83,653
)   $
(155,982
)
Adjustments to reconcile net loss to net cash used in operating activities:                        
Depreciation and amortization    
11,358
     
     
11,358
 
(Gain) loss on disposal of property, plant and equipment    
142
     
     
142
 
Stock-based compensation    
6,265
     
     
6,265
 
Amortization of debt discount    
12,490
     
2,749
     
15,239
 
(Gain) loss upon extinguishment of debt    
1,521
     
10,376
     
11,897
 
Receipt of equity in connection with collaboration arrangements revenue    
(2,661
)    
2,661
     
 
(Gain) loss from change in fair value of derivative liabilities    
1,742
     
47,110
     
48,852
 
(Gain) loss on foreign currency exchange rates    
(1,230
)    
     
(1,230
)
Noncash revenue reduction related to issuance of debt obligations    
     
13,413
     
13,413
 
Non-cash gain on divestiture    
(5,732
)    
     
(5,732
)
Receipt of noncash consideration in connection with license revenue    
(8,046
)    
     
(8,046
)
Changes in assets and liabilities:                        
Accounts receivable    
(19,647
)    
     
(19,647
)
Accounts receivable, unbilled – related party
   
(7,940
)    
     
(7,940
)
Inventories    
(3,126
)    
     
(3,126
)
Prepaid expenses and other assets    
(19,336
)    
606
     
(18,730
)
Accounts payable    
5,858
     
(406
)    
5,452
 
Accrued and other liabilities    
7,295
     
6,582
     
13,877
 
Contract liabilities    
(7,241
)    
     
(7,241
)
Net cash used in operating activities    
(100,617
)    
(562
)    
(101,179
)
Investing activities                        
Proceeds from divestiture    
54,827
     
     
54,827
 
Change in short-term investments    
712
     
581
     
1,293
 
Change in restricted cash    
865
     
(865
)    
 
Purchases of property, plant and equipment    
(4,412
)    
     
(4,412
)
Net cash (used in) provided by investing activities    
51,992
     
(284
)    
51,708
 
Financing activities                        
Proceeds from issuance of convertible preferred stock    
101,124
     
(2,878
)    
98,246
 
Proceeds from exercises of common stock options    
160
     
(160
)    
 
Payment of minimum employee taxes withheld upon net share settlement of restricted stock units    
(385
)    
     
(385
)
Proceeds from issuance of common stock in August 2017 offering    
     
5,759
     
5,759
 
Issuance costs incurred    
     
(2,159
)    
(2,159
)
Change in restricted cash related to contingently redeemable common stock    
1,046
     
(1,046
)    
 
Proceeds from issuance of debt, net of issuance costs    
18,925
     
     
18,925
 
Principal payments on debt    
(37,500
)    
     
(37,500
)
Payment of swap termination    
(3,113
)    
     
(3,113
)
Payment on early redemption of debt    
(1,909
)    
     
(1,909
)
Net cash provided by financing activities    
78,348
     
(484
)    
77,864
 
Effect of exchange rate changes on cash, cash equivalents and restricted cash    
186
     
     
186
 
Net (decrease) increase in cash, cash equivalents and restricted cash    
29,909
     
(1,330
)    
28,579
 
Cash, cash equivalents and restricted cash at beginning of year    
27,150
     
5,283
     
32,433
 
Cash, cash equivalents and restricted cash at end of year   $
57,059
     
3,953
     
61,012
 
                         
Reconciliation of cash, cash equivalents and restricted cash to the consolidated balance sheets                        
Cash and cash equivalents    
 
     
 
    $
57,059
 
Restricted cash, current    
 
     
 
     
2,994
 
Restricted cash, noncurrent    
 
     
 
     
959
 
Total cash, cash equivalents and restricted cash    
 
     
 
    $
61,012
 
                         
Supplemental disclosures of cash flow information:                        
Cash paid for interest   $
11,539
    $
    $
11,539
 
Supplemental disclosures of non-cash investing and financing activities:                        
Issuance of common stock upon conversion of debt   $
28,702
    $
    $
28,702
 
Accrued interest added to debt principal   $
2,816
    $
    $
2,816
 
Issuance of common stock for settlement of debt principal and interest payments   $
3,436
    $
    $
3,436
 
Financing of insurance premium under note payable   $
467
    $
    $
467
 
Issuance of convertible preferred stock upon conversion of debt   $
40,204
    $
    $
40,204
 
Settlement of debt principal by a related party   $
25,000
    $
    $
25,000
 
Issuance of note payable in exchange for debt extinguishment with third party   $
16,954
    $
    $
16,954
 
Issuance of common stock for settlement of debt   $
10,708
    $
    $
10,708
 
Issuance of preferred stock attributed to derivative liabilities   $
    $
72,725
    $
72,725
 
 
(
1
) To reflect the impact of restatement corrections on the statement of cash flows.
XML 33 R19.htm IDEA: XBRL DOCUMENT v3.19.3
Note 10 - Revenue Recognition
12 Months Ended
Dec. 31, 2018
Notes to Financial Statements  
Collaborative Arrangement Disclosure [Text Block]
10.
Revenue Recognition
 
Disaggregation of Revenue
 
The following tables present revenue by primary geographical market, based on the location of the customer, as well as by major product and service:
 
Years Ended December 31,
(In thousands)
  2018   2017
        (As Restated, Note 2)
Europe   $
29,405
    $
23,823
 
United States    
26,241
     
78,286
 
Asia    
6,331
     
23,290
 
Brazil    
942
     
2,159
 
Other    
685
     
113
 
    $
63,604
    $
127,671
 
 
Significant Revenue Agreements
 
For
the years ended
December 
31,
2018
and
2017,
the Company recognized revenue in connection with significant revenue agreements and from all other customers as follows:
 
Years Ended December 31,
(In thousands)
  2018   2017 (As Restated, Note 2)
    Renewable Products   Licenses and Royalties   Grants and Collaborations   TOTAL   Renewable Products   Licenses and Royalties   Grants and Collaborations   TOTAL
Revenue from significant revenue agreements with:                                                                
DSM (related party)   $
18
    $
5,958
    $
4,735
    $
10,711
    $
    $
57,972
    $
1,679
    $
59,651
 
Firmenich    
3,727
     
1,700
     
5,717
     
11,144
     
9,621
     
1,199
     
5,803
     
16,623
 
DARPA    
     
     
8,436
     
8,436
     
     
     
12,333
     
12,333
 
Givaudan    
4,078
     
     
4,358
     
8,436
     
1,950
     
     
6,000
     
7,950
 
Nenter    
     
     
     
     
12,057
     
2,633
     
     
14,690
 
Ginkgo    
     
     
     
     
     
(13,113
)    
     
(13,113
)
Subtotal revenue from significant revenue agreements    
7,823
     
7,658
     
23,246
     
38,727
     
23,628
     
48,691
     
25,815
     
98,134
 
Revenue from all other customers    
25,775
     
     
(898
)    
24,877
     
18,742
     
12
     
10,783
     
29,537
 
Total revenue from all customers   $
33,598
    $
7,658
    $
22,348
    $
63,604
    $
42,370
    $
48,703
    $
36,598
    $
127,671
 
 
Renewable
Products
 
Firmenich Agreements
 
In
2013,
the Company entered into a collaboration agreement with Firmenich SA (Firmenich) (as amended, the Firmenich Collaboration Agreement), for the development and commercialization of multiple renewable flavors and fragrances compounds. In
2014,
the Company entered into a supply agreement with Firmenich (Firmenich Supply Agreement) for compounds developed under the Firmenich Collaboration Agreement. 
The Firmenich Collaboration Agreement and 
Firmenich Supply Agreement (F
irmenich Agreements) are considered for revenue recognition purposes to comprise a single multiple-element arrangement.
 
In
July 2017, 
the 
Company and Firmenich entered into an amendment of the Firmenich Collaboration Agreement, pursuant to which the parties agreed to exclude certain compounds from the scope of the agreement and to amend certain terms connected with the supply and use of such compounds when commercially produced. In addition, the parties agreed to (i) fix at a
70/30
basis (
70%
for Firmenich) the ratio at which the parties will share profit margins from sales of
two
compounds; (ii) set at a
70/30
basis (
70%
for Firmenich) the ratio at which the parties will share profit margins from sales of a distinct form of compound until Firmenich receives
$15.0
million more than the Company in the aggregate from such sales, after which time the parties will share the profit margins
50/50
and (iii) a maximum Company cost of a compound where a specified purchase volume is satisfied, and alternative production and margin share arrangements in the event such Company cost cap is
not
achieved.
 
In
August 2018,
the Company and Firmenich entered into a
second
supply agreement (Firmenich Amended and Restated Supply Agreement), which incorporates all previous amendments and new changes and supersedes the
September 2014
supply agreement. With this Amended and Restated Supply Agreement, the parties agreed on the compounds to be supplied under the agreement and the commercial specifications of these products, and made some adjustments to the pricing of the compounds.
 
Pursuant to the Firmenich Collaboration Agreement, the Company agreed to pay a
one
-time success bonus to Firmenich of up to
$2.5
million 
if certain commercialization targets are met. Such targets have
not
yet been met as of
December 
31,
2018.
 
The
one
-time success bonus will expire upon termination of the Firmenich Collaboration Agreement, which has an initial term of
10
years and will automatically renew at the end of such term (and at the end of any extension) for an additional
3
-year term unless otherwise terminated. At
December 
31,
2018
, the Company had a
$0.5
million liability associated with this
one
-time success bonus
that has been recorded as a reduction to the associated collaboration revenue.
 
Nenter Agreements
 
In 
April 2016,
the Company and Nenter & Co., Inc. (Nenter) entered into a renewable farnesene supply agreement (Nenter Supply Agreement) under which the Company agreed to supply farnesene and provide certain exclusive purchase rights, and Nenter committed to purchase minimum quantities and make quarterly royalty payments to the Company representing a portion of Nenter's profit on the sale of products produced using farnesene purchased under the agreement. The agreement expires
December 31, 2020
and will automatically renew for an additional
five
years unless otherwise terminated. In
December 2017,
the Company assigned the Nenter Supply Agreement to DSM in connection with the Company's sale of its subsidiary Amyris Brasil Ltda., which owned and operated the Brotas, Brazil production facility; see Note
13,
"Divestiture" and Note
11,
"Related Party Transactions" for additional information.
 
Licenses and Royalties
 
DSM
Agreements
 
DSM
July
and
September 2017
Collaboration and Licensing Agreements
 
In
 
July
and 
September 
2017,
the Company entered into
three
separate collaboration agreements with DSM (DSM Collaboration Agreements) to jointly develop
three
new molecules in the Health & Wellness (DSM Ingredients) market using the Company’s technology, which the Company would produce and DSM would commercialize. Pursuant to the DSM Collaboration Agreements, DSM will, subject to certain conditions, provide funding for the development of the DSM Ingredients and, upon commercialization, the parties would enter into supply agreements whereby DSM would purchase the applicable DSM Ingredients from the Company at prices agreed by the parties. The development services will be directed by a joint steering committee with equal representation by DSM and the Company. In addition, the parties will share profit margin from DSM’s sales of products that incorporate the DSM Ingredients subject to the DSM Collaboration Agreements.
 
In
 
connection with the entry into the DSM Collaboration Agreements, the Company and DSM also entered into certain license arrangements (DSM License Agreements) providing DSM with certain rights to use the technology underlying the development of the DSM Ingredients to produce and sell products incorporating the DSM Ingredients. Under the DSM License Agreements, DSM agreed to pay the Company
$9.0
million for a worldwide, exclusive, perpetual, royalty-free license to produce and sell products incorporating
one
of the DSM Ingredients in the Health & Wellness field.
 
As discussed in Note
7,
“Stockholders’ Deficit”, the Company received
$34.0
million of fixed consideration resulting from the
August 2017
DSM Offering and the DSM License Agreements, discussed above, and allocated this consideration to the various elements identified. The Company
first
allocated
$10.6
million to the
August 2017
DSM Cash Warrants and DSM Dilution Warrants liabilities and
$15.6
million of the proceeds to the
August 2017
DSM Series B Preferred Stock. The remaining proceeds in excess of the fair value the equity awards and warrants of
$7.8
million was available for recognition as revenue generated from the delivery of the intellectual property licenses to DSM.
 
In connection with the entry into the DSM Agreements, the Company and DSM entered into the DSM Credit Letter, pursuant to which the Company granted a credit to DSM in an aggregate amount of
$12.0
million to be offset against future collaboration payments (in an amount
not
to exceed
$6.0
million) and royalties receivable from DSM beginning in
2018.
  The
$7.8
million available for revenue recognition was reduced by an apportionment of the credit and allocated between delivered license revenue and future revenues associated with the collaboration agreements. This resulted in the recognition of
$3.3
million in licenses revenue under the DSM License Agreements and the remaining amount of
$4.5
million being recorded as deferred revenue. During the
three
months ended
December 31, 2017,
the Company and DSM terminated the DSM Credit Letter, eliminating the
$12.0
million credit from the DSM Collaboration Agreements. As a result of the cancelation of the Credit Letter, the
$4.5
million of deferred revenue was included as an element of consideration in the series of
December 2017
DSM agreements described below, which were evaluated as a combined transaction for accounting purposes in conjunction with the sales of the Brotas
1
facility discussed more fully in Note
11,
"Related Party Transactions" and Note
13,
"Divestiture".
 
DSM
Value Sharing Agreement
 
In
December 2017,
in conjunction with the Company's divestiture of its Brotas, Brazil production facility (see Note
13,
"Divestiture" and Note
11,
"Related Party Transactions"), the Company and DSM entered into a value sharing agreement (Value Sharing Agreement), pursuant to which DSM agreed to make certain royalty payments to the Company representing a portion of the profit on the sale of products produced using farnesene purchased under the Nenter Supply Agreement realized by Nenter and paid to DSM in accordance with the Nenter Supply Agreement. In addition, pursuant to the Value Sharing Agreement, DSM agreed to guarantee certain minimum annual royalty payments for the
first
three
calendar years of the Value Sharing Agreement, subject to future offsets in the event that the royalty payments to which the Company would otherwise have been entitled under the Value Sharing Agreement for such years fall below certain milestones. The fair value of the nonrefundable minimum annual royalty payments were determined to be fixed and determinable, and were included as part of the total arrangement consideration subject to allocation of the overall multiple-element transaction that occurred in
December 2017
with DSM. Under the Value Sharing Agreement, the Company is required to use certain royalty payments received by the Company with respect to the
first
three
calendar years of the Value Sharing Agreement in excess of the guaranteed minimum annual royalty payments for such years, if any, to repay amounts outstanding under the DSM Credit Agreement; however, in
2018,
the Company did
not
receive royalty payments in excess of the guaranteed minimum annual amount. See Note
5,
"Debt". The Value Sharing Agreement will expire in
December 2027,
subject to the right of each of the parties to terminate for uncured material breach by the other party or in the event the other party is subject to bankruptcy proceedings, liquidation, dissolution or similar proceedings or other specified events. During
2018,
the Company and DSM amended the Value Sharing Agreement to (i) provide for the use of estimates in calculating quarterly royalty payments (subject to true-up), (ii) modify how the guaranteed minimum annual royalty payment for
2018
will be offset against value payments accruing during
2018
and (iii) accelerate the minimum annual royalty payment for
2019
from
December 31, 2018
to
June 30, 2018
in exchange for a fee of
$750,000.
For the year ended
December 31, 2018,
the Company recognized
$7.9
million of revenue in connection with the DSM Value Sharing Agreement.
 
In
April 2019,
the Company assigned to DSM all the Company’s rights and obligations under the Value Sharing Agreement. See Note
16,
“Subsequent Events” for additional information.
 
DSM Performance Agreement
 
In
December 2017,
in connection with the Company's divestiture of its Brotas, Brazil production facility (see Note
13,
"Divestiture"), the Company and DSM entered into a performance agreement (Performance Agreement), pursuant to which the Company will provide certain research and development services to DSM relating to the development of the technology underlying the farnesene-related products to be manufactured at the Brotas facility in exchange for related funding, including certain bonus payments in the event that specific performance metrics are achieved. The Company will record the bonus payments as earned revenue upon the transfer of the developed technology to DSM. If the Company does
not
meet the established metrics under the Performance Agreement, the Company will be required to pay
$1.8
million to DSM. The Performance Agreement will expire in
December 2020,
subject to the right of each of the parties to terminate for uncured material breach by the other party or in the event the other party is subject to bankruptcy proceedings, liquidation, dissolution or similar proceedings or other specified events.
 
In
April 2019,
the Company and DSM amended the Performance Agreement. See Note
16,
“Subsequent Events” for additional information.
 
DSM
November 2017
Intellectual Property License Agreement
 
In
November 2017,
in connection with the Company's divestiture of its Brotas, Brazil production facility (see Note
13,
"Divestiture"), the Company and DSM entered into a license agreement covering certain intellectual property of the Company useful in the performance of certain commercial supply agreements assigned by the Company to DSM relating to products currently manufactured at the Brotas facility (DSM
November 2017
Intellectual Property License Agreement). In
December 2017,
DSM paid the Company an upfront license fee of
$27.5
million. In accounting for the Divestiture with DSM, a multiple-element arrangement, the license of intellectual property to DSM was identified as revenue deliverable with standalone value and qualified as a separate unit of accounting. The Company performed an analysis to determine the fair value for of the license, and allocated the non-contingent consideration based on the relative fair value. The Company determined that the license had been fully delivered, and, as such, license revenue of
$54.6
million was recognized for the period ended
December 31. 2017.
 
DSM
December 2017
Supply Agreement and
November 2018
Supply Agreement Amendment
 
On
November 19, 2018,
the Company and DSM entered into an amendment (Supply Agreement Amendment) to the supply agreement, dated
December 28, 2017 (
Supply Agreement), by and between the Company and DSM. Under the Supply Agreement, DSM agreed to manufacture and supply to the Company certain products useful in the Company’s business, at prices and on production and delivery terms and specifications set forth in the Supply Agreement, which prices are based upon DSM’s manufacturing cost plus an agreed margin. The Supply Agreement originally provided that it would expire (i) with respect to non-farnesene related products, on the date that the Company’s planned new specialty ingredients manufacturing facility in Brazil is fully operational and meets its production targets, but in any event
no
later than
December 31, 2021
and (ii) with respect to farnesene related products, on
December 28, 2037,
subject in each case to earlier termination in certain circumstances. Pursuant to the Supply Agreement Amendment, (i) the outside expiration date of the Supply Agreement with respect to non-farnesene related products was extended to
December 31, 2022,
with specified pricing terms added for products manufactured during
2022,
(ii) DSM committed to produce certain non-farnesene related products for the Company for
two
months of each calendar year during the term of the Supply Agreement and (iii) the Company agreed to (A) pay DSM a cash fee totaling
$15.5
million, payable in installments during
2018
and
2019,
(B) issue
1,643,991
shares of the Company's common stock to DSM, and (C) pay DSM a cash fee of
$7.3
million, payable on or before
March 29, 2019,
plus, if the closing price of the Common Stock on the trading day immediately preceding the date of such payment is less than
$4.41
per share, an amount equal to such deficiency multiplied by
1,643,991.
 
The Company also entered into other transactions with DSM in
November 2018
which resulted in the Company (i) accounting for this series of transactions, including the Supply Agreement Amendment, and certain other transactions with DSM in
2018
as a combined arrangement, and (ii) determining and allocating the fair value to each element. See Note
11,
“Related Party Transactions” for additional information.
 
In
April 2019,
the Company and DSM further amended the Supply Agreement. See Note
16,
“Subsequent Events” for additional information.
 
DSM
November 2018
Letter Agreement
 
On
November 19, 2018,
the Company and DSM entered into a letter agreement (
November 2018
DSM Letter Agreement), pursuant to which the Company agreed (i) to cause the removal of certain existing liens on intellectual property owned by the Company and licensed to DSM and (ii) if such liens were
not
removed prior to
December 15, 2018,
to issue to DSM shares of the Company’s common stock with a value equal to
$5.0
million. On
December 14, 2018,
the Company entered into an amendment to the GACP Term Loan Facility to remove such lien, and the
November 2018
DSM Letter Agreement was thereby terminated.
 
Ginkgo
Agreements
 
Ginkgo Initial Strategic Partnership Agreement and Collaboration Agreement
 
In
June 2016,
the Company entered into a collaboration agreement (Initial Ginkgo Agreement) with Ginkgo Bioworks, Inc. (Ginkgo), pursuant to which the Company licensed certain intellectual property to Ginkgo in exchange for a fee of
$20.0
million to be paid by Ginkgo to the Company in
two
installments, and a
10%
royalty on net revenue, including without limitation net sales, royalties, fees and any other amounts received by Ginkgo related directly to the license. The Company received the
first
installment of
$15.0
million in
July 2016,
which the Company recognized as revenue in
2016.
However, the Company did
not
receive the
second
installment of
$5.0
million, as the Company did
not
meet the milestone criteria for the receipt of such payment.
 
In
September 2016,
the Company and Ginkgo entered into a collaboration agreement (Ginkgo Collaboration Agreement) setting forth the terms of the Ginkgo Collaboration, under which the parties would collaborate to develop, manufacture and sell commercial products, and Ginkgo would pay royalties to the Company. The Ginkgo Collaboration Agreement provided that, subject to certain exceptions, all
third
-party contracts for the development of chemical small molecule compounds whose manufacture is enabled by the use of microbial strains and fermentation technologies that are entered into by the Company or Ginkgo during the term of the Ginkgo Collaboration Agreement would be subject to the Ginkgo Collaboration and the approval of the other party (
not
to be unreasonably withheld). Responsibility for the engineering and small-scale process development of the newly developed products would be allocated between the parties on a project-by-project basis, and the Company would be principally responsible for the commercial scale-up and production of such products, with each party generally bearing its own respective costs and expenses relating to the Ginkgo Collaboration, including capital expenditures.
 
Under the Ginkgo Collaboration Agreement, subject to certain exceptions, including excluded or refused products and cost savings initiatives, the profit on the sale of products subject to the Ginkgo Collaboration Agreement as well as cost-sharing, milestone and “value-creation” payments associated with the development and production of such products would be shared equally between the parties. The parties also agreed to provide each other with a license and other rights to certain intellectual property necessary to support the development and manufacture of the products under the Ginkgo Collaboration, and also to provide each other with access to certain other intellectual property useful in connection with the activities to be undertaken under the Ginkgo Collaboration Agreement, subject to certain carve-outs.
 
Ginkgo Partnership Agreement
 
In
November 2017,
the Company and Ginkgo entered into a partnership agreement (Ginkgo Partnership Agreement) to replace and supersede the Ginkgo Collaboration Agreement. Under the Ginkgo Partnership Agreement, the Company and Ginkgo agreed:
  to continue to collaborate on limited research and development;
  to provide each other licenses (with royalties) to specified intellectual property for limited purposes;
  for the Company to pay Ginkgo quarterly fees of
$0.8
million (Partnership Payments) for a total of
$12.7
million, beginning on
December 31, 2018
and ending on
September 30, 2022;
  to share profit margins from sales of a certain product to be developed under the Ginkgo Partnership Agreement on a
50/50
basis, subject to certain conditions, provided that net profits will be payable to Ginkgo for any quarterly period to the extent that such net profits exceed the sum of (a) quarterly interest payments due under the
November 2017
Ginkgo Note (see Note
5,
"Debt") and (b) Partnership Payments due in such quarter;
 
  for the Company to issue the
$12
million Ginkgo Note which effectively guarantees Ginkgo
$12
million minimum future royalties under the profit margin sharing provisions noted above; and
 
  for the Company to pay Ginkgo
$0.5
million in connection with certain fees previously owed to Ginkgo under the Ginkgo Collaboration Agreement.
 
The Ginkgo Partnership Agreement provides for an initial term of
two
years and will automatically renew for successive
one
-year terms thereafter unless otherwise terminated. The Company does
not
expect to recognize any future revenue under this arrangement.
 
The Company recorded the
$6.1
million present value of the
$12.7
million partnership payments as an other liability (see Note
3,
"Balance Sheet Details"), with the remaining
$6.6
million recorded as a debt discount to be recognized as interest expense under the effective interest method over the
five
-year payment term. The Company also concluded the partnership payment obligation under the Ginkgo Partnership Agreement represents consideration payable to a former customer; and consequently, the present value of the partnership payments should be recorded as a reduction of cumulative revenue recognized to date from Ginkgo in the period the partnership agreement was executed. As a result, the Company recorded a
$6.1
million reduction in license revenues for the year ended
December 31, 2017.
The Company reached a similar conclusion regarding the
$12.0
million Ginkgo Note (see Note
5,
"Debt" under the “Ginkgo Note” section for further discussion regarding the accounting treatment of the Ginkgo Note) and recorded an additional
$7.0
million reduction in license revenue for the year ended
December 31, 2017
related to the present value of the Ginkgo Note. In total, the Company recorded a
$13.1
million reduction in licenses and royalties revenue and
$13.1
million in notes payable and other liabilities as of and for the year ended
December 31, 2017
upon execution of the Ginkgo Partnership Agreement.
 
Collaborations
 
DARPA Technology Investment Agreement
 
In
September 2015,
the Company entered into a technology investment agreement (TIA) with The Defense Advanced Research Projects Agency (DARPA), under which the Company, with the assistance of specialized subcontractors, is working to create new research and development tools and technologies for strain engineering and scale-up activities. The agreement is being funded by DARPA on a milestone basis. Under the TIA, the Company and its subcontractors could collectively receive DARPA funding of up to
$35.0
million over the program’s
four
year term if all of the program’s milestones are achieved. In conjunction with DARPA’s funding, the Company and its subcontractors are obligated to collectively contribute approximately
$15.5
million toward the program over its
four
year term (primarily by providing specified labor and/or purchasing certain equipment). For the DARPA agreement, the Company recognizes revenue using an output-based measure of progress of the milestones completed relative to remaining milestones, once acknowledged by DARPA.
 
Contract Assets and Liabilities
 
When a contract results in revenue being recognized in excess of the amount the Company has invoiced or has the right to invoice to the customer, a contract asset is recognized. Contract assets are transferred to accounts receivable, net when the rights to the consideration become unconditional. Contract assets are presented as Accounts receivable, unbilled – related party on the consolidated balance sheets.
 
Contract liabilities consist of payments received from customers, or such consideration that is contractually due, in advance of providing the product or performing services such that control has
not
passed to the customer.
 
Trade receivables related to revenue from contracts with customers are included in accounts receivable on the consolidated balance sheets, net of the allowance for doubtful accounts. Trade receivables are recorded at the point of renewable product sale or in accordance with the contractual payment terms for licenses and royalties, and grants and collaborative research and development services for the amount payable by the customer to the Company for sale of goods or the performance of services, and for which the Company has the unconditional right to receive payment.
 
Contract Balances
 
The following table provides information about accounts receivable and contract liabilities from contracts with customers:
 
December 31,
(In thousands)
  2018   2017
Accounts receivable, net   $
16,003
    $
18,953
 
Accounts receivable - related party, net   $
1,349
    $
4,767
 
Accounts receivable, unbilled - related party   $
8,021
    $
9,901
 
Accounts receivable, unbilled, noncurrent - related party   $
1,203
    $
7,940
 
Contract liabilities
(1)
  $
8,236
    $
4,308
 
Contract liabilities, noncurrent
(2)
  $
1,587
    $
 
 
(
1
)    
The balance in contract liabilities, current at
December 31, 2017
represents deferred revenue, current prior to the Company's adoption of ASC
606,
"Revenue".
(
2
)    
The balances in contract liabilities, noncurrent are included in other noncurrent liabilities on the consolidated balance sheets. 
 
Unbilled receivables relate to the Company’s right to consideration from DSM for (i) minimum future royalties and (ii) a material right arising from a customer option for a future transfer of technology. The Company’s right to cash receipt for these minimum royalty amounts occurs on or before
December 31, 2019,
and the right to cash receipt for the customer option occurs on or before
December 31, 2020.
 
Contract liabilities, current increased by
$3.9
million at
December 
31,
2018
resulting from a
$0.8
million increase upon adoption of ASC
606
on
January 1, 2018
plus the net amount of collaboration and royalty revenues invoiced in excess of amounts recognized as revenue, less
$3.3
million of revenue recognized during the year ended
December 
31,
2018
that was included in deferred revenue at the beginning of the period.
 
Remaining Performance Obligations
 
The following table provides information regarding the estimated revenue expected to be recognized in the future related to performance obligations that are unsatisfied (or partially unsatisfied) based on the Company's existing agreements with customers as of
December 
31,
2018.
 
(In thousands)
  As of December 31, 2018
2019   $
14,131
 
2020    
7,925
 
2021    
 
2022 and thereafter    
 
Total from all customers   $
22,056
 
 
In accordance with the disclosure provisions of ASC
606,
the table above excludes estimated future revenues for performance obligations that are part of a contract that has an original expected duration of
one
year or less or a performance obligation with variable consideration that is recognized using the sales-based royalty exception for licenses of intellectual property. Additionally,
$21.4
million of estimated future revenue is excluded from the table above, as that amount represents constrained variable consideration.
XML 34 R32.htm IDEA: XBRL DOCUMENT v3.19.3
Note 7 - Stockholders' Deficit (Tables)
12 Months Ended
Dec. 31, 2018
Notes Tables  
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
Transaction   Number Outstanding as of
December 31, 2017
  Additional
Warrants Issued
  Exercises   Number Outstanding as of
December 31, 2018
August 2018 warrant exercise agreements    
     
12,097,164
     
     
12,097,164
 
May 2017 cash and dilution warrants    
18,042,568
     
     
(11,749,770
)    
6,292,798
 
August 2017 cash and dilution warrants    
9,543,234
     
1,713,565
     
(7,288,683
)    
3,968,116
 
April 2018 warrant exercise agreements    
     
3,616,174
     
     
3,616,174
 
July 2015 related party debt exchange    
2,082,010
     
471,204
     
(1,889,986
)    
663,228
 
February 2016 related party private placement    
171,429
     
     
     
171,429
 
July 2015 private placement    
81,197
     
     
     
81,197
 
Other    
1,406
     
     
     
1,406
 
     
29,921,844
     
17,898,107
     
(20,928,439
)    
26,891,512
 
Schedule of Debt Conversions [Table Text Block]
Debt Instrument   Number of Shares into Which
Debt Instrument Is Convertible
as of December 31, 2018
6% convertible notes due 2021    
9,493,672
 
2015 Rule 144A convertible notes    
2,338,560
 
August 2013 financing convertible notes    
1,003,554
 
2014 Rule 144A convertible notes    
867,376
 
     
13,703,162
 
XML 35 R36.htm IDEA: XBRL DOCUMENT v3.19.3
Note 11 - Related Party Transactions (Tables)
12 Months Ended
Dec. 31, 2018
Notes Tables  
Schedule of Related Party Debt [Table Text Block]
December 31,

(in thousands)
  2018   2017
    Principal   Unamortized
Debt
(Discount)
Premium
  Net   Principal   Unamortized
Debt
(Discount)
Premium
  Net
Total                        
2014 Rule 144A convertible notes   $
9,705
    $
(422
)   $
9,283
    $
9,705
    $
(1,538
)   $
8,167
 
August 2013 financing convertible notes    
     
     
     
21,711
     
897
     
22,608
 
R&D note    
     
     
     
3,700
     
(18
)    
3,682
 
     
9,705
     
(422
)    
9,283
     
35,116
     
(659
)    
34,457
 
DSM                                                
DSM note    
25,000
     
(6,311
)    
18,689
     
25,000
     
(8,039
)    
16,961
 
Other DSM loan    
     
     
     
393
     
     
393
 
     
25,000
     
(6,311
)    
18,689
     
25,393
     
(8,039
)    
17,354
 
Biolding                                                
February 2016 private placement    
     
     
     
2,000
     
     
2,000
 
                                                 
Foris                                                
2014 Rule 144A convertible notes    
5,000
     
(181
)    
4,819
     
5,000
     
(660
)    
4,340
 
                                                 
Temasek                                                
2014 Rule 144A convertible notes    
10,000
     
(435
)    
9,565
     
10,000
     
(1,591
)    
8,409
 
    $
49,705
    $
(7,349
)   $
42,356
    $
77,509
    $
(10,949
)   $
66,560
 
Schedule of Related Party Revenues [Table Text Block]
Years Ended December 31,
(In thousands)
  2018   2017 (As restated, Note 2)
    Renewable Products   Licenses and Royalties   Grants and Collaborations   TOTAL   Renewable Products   Licenses and Royalties   Grants and Collaborations   TOTAL
Revenue from related parties:                                                                
DSM   $
18
    $
5,958
    $
4,735
    $
10,711
    $
    $
57,972
    $
1,679
    $
59,651
 
Total    
342
     
     
     
342
     
(200
)    
     
     
(200
)
Novvi    
     
     
     
     
1,491
     
     
     
1,491
 
Subtotal revenue from related parties    
360
     
5,958
     
4,735
     
11,053
     
1,291
     
57,972
     
1,679
     
60,942
 
Revenue from all other customers
(1)
   
33,238
     
1,700
     
17,613
     
52,551
     
41,079
     
(9,269
)    
34,919
     
66,729
 
Total revenue from all customers   $
33,598
    $
7,658
    $
22,348
    $
63,604
    $
42,370
    $
48,703
    $
36,598
    $
127,671
 
Schedule of Related Party Accounts Receivables [Table Text Block]
December 31,

(In thousands)
  2018   2017
DSM   $
1,071
    $
12,823
 
Novvi    
188
     
1,607
 
Total    
90
     
238
 
Related party accounts receivable, net   $
1,349
    $
14,668
 
Schedule of Related Party Assets and Liabilities [Table Text Block]
December 31,
(In thousands)
  2018   2017
Assets   $
12,904
    $
7,635
 
Liabilities   $
2,364
    $
3,187
 
XML 36 R57.htm IDEA: XBRL DOCUMENT v3.19.3
Note 4 - Fair Value Measurement - Reconciliation for Compound Embedded Derivative Liability (Details) - Fair Value, Inputs, Level 3 [Member] - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Fair value at issuance on December 10, 2018 $ 116,497 $ 4,135
Additions 4,089 133,517
Change in fair value 30,880 48,852
Derecognition to additional paid-in capital upon conversion or extinguishment (108,670) (70,007)
Fair value at December 31, 2018 $ 42,796 $ 116,497
XML 37 R53.htm IDEA: XBRL DOCUMENT v3.19.3
Note 4 - Fair Value Measurement (Details Textual)
shares in Millions, R$ in Millions
12 Months Ended
Mar. 29, 2019
USD ($)
Nov. 19, 2018
USD ($)
shares
Dec. 31, 2018
USD ($)
Dec. 10, 2018
USD ($)
Dec. 06, 2018
USD ($)
Dec. 31, 2017
USD ($)
Aug. 31, 2017
USD ($)
Jun. 30, 2012
USD ($)
Jun. 30, 2012
BRL (R$)
Long-term Debt, Gross     $ 228,921,000     $ 195,819,000      
Long-term Debt, Fair Value     57,918,000     0      
Derivative Liability, Total     42,796,000     116,497,000      
Debt, Long-term and Short-term, Combined Amount, Total     151,700,000     165,400,000      
Debt Instrument, Fair Value Disclosure, Total     149,300,000     $ 156,900,000      
Stock Issued During Period, Value, New Issues     $ 1,415,000            
Supply Agreement, Fair Value Consideration   $ 33,304,000              
DSM Supply Agreement [Member]                  
Contract with Customer, Asset, after Allowance for Credit Loss, Total   $ 22,700,000              
Stock Issued During Period, Shares, New Issues | shares   1,643,991              
Stock Issued During Period, Value, New Issues   $ 6,100,000              
Supply Agreement, Warrant Modification Amount   2,900,000              
Supply Agreement, Payments for Obligation Settlements   1,800,000              
Supply Agreement, Fair Value Consideration   $ 33,300,000              
DSM Supply Agreement [Member] | Subsequent Event [Member]                  
Stock Issued During Period, Value, New Issues $ 7,300,000                
May 2017 warrants , May 2017 Offering Make Whole Provision [Member]                  
Derivative Liability, Total             $ 113,100,000    
Interest Rate Swap [Member] | Banco Pine [Member]                  
Derivative, Notional Amount               $ 6,600,000 R$ 22
Derivative, Fixed Interest Rate               3.94% 3.94%
Measurement Input, Discount Rate [Member] | DSM Supply Agreement [Member]                  
Supply Agreement, Measurement Input   0.225              
Discount to Gross Cash Flows [Member] | DSM Supply Agreement [Member]                  
Supply Agreement, Measurement Input   0              
Convertible Senior Notes, 6.0% Due in 2021 [Member]                  
Debt Instrument, Face Amount       $ 60,000,000 $ 60,000,000        
Debt Instrument, Interest Rate, Stated Percentage     6.00% 6.00% 6.00%        
Long-term Debt, Gross     $ 60,000,000            
Long-term Debt, Fair Value     $ 57,900,000            
Convertible Senior Notes, 6.0% Due in 2021 [Member] | Measurement Input, Discount Rate [Member]                  
Long-term Debt, Measurement Input     0.252            
Convertible Senior Notes, 6.0% Due in 2021 [Member] | Measurement Input, Price Volatility [Member]                  
Long-term Debt, Measurement Input     0.45            
Convertible Senior Notes, 6.0% Due in 2021 [Member] | Probability of Principal Repayment in Cash [Member]                  
Long-term Debt, Measurement Input     0.5            
Convertible Senior Notes, 6.0% Due in 2021 [Member] | Probability of Principal Repayment in Stock [Member]                  
Long-term Debt, Measurement Input     0.5            
Convertible Senior Notes, 6.0% Due in 2021 [Member] | Measurement Input, Probability of Change in Control [Member]                  
Fair Value Adjustment of Debt     $ 2,100,000            
XML 38 R88.htm IDEA: XBRL DOCUMENT v3.19.3
Note 12 - Stock-based Compensation - Share-based Compensation, Stock Options and Stock Appreciation Rights Award Activity (Details) - USD ($)
$ / shares in Units, $ in Thousands
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Outstanding (in shares) 1,338,367  
Outstanding, weighted average exercise price (in dollars per share) $ 33.40  
Outstanding, weighted average remaining contractual life (Year) 8 years 182 days 7 years 255 days
Outstanding, aggregate intrinsic value $ 29 $ 97
Options granted (in shares) 4,337,119 661,094
Granted, weighted average exercise price (in dollars per share) $ 5.18  
Exercised (in shares) (70,807)  
Exercised, weighted average exercise price (in dollars per share) $ 3.68  
Forfeited or expired (in shares) (214,409)  
Forfeited or expired, weighted average exercise price (in dollars per share) $ 19.61  
Outstanding (in shares) 5,390,270 1,338,367
Outstanding, weighted average exercise price (in dollars per share) $ 11.55 $ 33.40
Vested or expected to vest (in shares) 4,833,615  
Vested and expected to vest, weighted average exercise price (in dollars per share) $ 12.28  
Vested and expected to vest, weighted average remaining contractual life (Year) 8 years 146 days  
Vested and expected to vest, aggregate intrinsic value $ 28  
Exercisable (in shares) 972,229  
Exercisable, weighted average exercise price (in dollars per share) $ 39.73  
Exercisable, weighted average remaining contractual life (Year) 5 years 292 days  
Exercisable, aggregate intrinsic value $ 12  
XML 39 R78.htm IDEA: XBRL DOCUMENT v3.19.3
Note 11 - Related Party Transactions (Details Textual) - USD ($)
1 Months Ended 3 Months Ended 12 Months Ended 36 Months Ended
Dec. 28, 2017
Jun. 30, 2018
Dec. 31, 2016
Dec. 31, 2018
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2019
Derivative Liability, Total       $ 42,796,000   $ 42,796,000 $ 116,497,000  
Accounts Receivable, Related Parties       1,349,000   1,349,000 14,668,000  
Due to Related Parties, Current, Total       23,667,000   23,667,000 20,019,000  
Revenue from Contract with Customer, Including Assessed Tax           63,604,000 127,671,000  
Working Capital       119,500,000   119,500,000    
Contract with Customer, Liability, Current [1],[2]       8,236,000   8,236,000 4,308,000 [3]  
Contract with Customer, Liability, Noncurrent [4]       $ 1,587,000   1,587,000  
Operating Leases, Rent Expense, Sublease Rentals           $ 600,000 500,000  
Nikko [Member] | First Aprinnova Loan [Member]                
Debt Instrument, Face Amount     $ 500,000          
Nikko [Member] | Second Aprinnova Loan [Member]                
Debt Instrument, Face Amount     1,500,000          
Aprinnova JV [Member] | Nikko [Member]                
Equity Method Investment, Ownership Percentage       50.00%   50.00%    
Payments to Acquire Businesses, Gross     10,000,000          
Notes Receivable, Related Parties     $ 3,900,000          
Forecast [Member] | Aprinnova JV [Member] | Nikko [Member] | Maximum [Member]                
Proceeds from Equity Method Investment, Distribution, Return of Capital               $ 10,000,000
Licenses and Royalties [Member]                
Revenue from Contract with Customer, Including Assessed Tax           $ 7,658,000 48,703,000 [5]  
Related Party Convertible Notes [Member]                
Derivative Liability, Total       $ 200,000   200,000 0  
Derivative, Gain (Loss) on Derivative, Net, Total           (8,500,000) 600,000  
Ginkgo Collaboration Agreement [Member] | Licenses and Royalties [Member]                
Contract with Customer, Asset, Cumulative Catch-up Adjustment to Revenue, Modification of Contract             13,100,000  
DSM International B.V. [Member]                
Accounts Receivable, Related Parties       1,071,000   1,071,000 12,823,000  
Revenue from Contract with Customer, Including Assessed Tax   $ 9,300,000            
Disposal Group, Including Discontinued Operation, Consideration $ 17,800,000              
Contract with Customer, Liability, Total       34,700,000   34,700,000    
Legal Fees           6,800,000    
Working Capital       2,100,000   2,100,000    
Contract with Customer, Liability, Current       1,204,000   1,204,000 383,000  
Post-closing Working Capital Adjustment Payment Recorded as Loss on Divestiture           2,100,000    
Contract with Customer, Liability, Fair Value Adjustment       1,400,000        
DSM International B.V. [Member] | Contract Assets - Related Party and Contract Assets, Noncurrent - Related Party [Member]                
Accounts Receivable, Related Parties       8,000,000   8,000,000    
DSM International B.V. [Member] | Other Assets [Member]                
Accounts Receivable, Related Parties       4,300,000   4,300,000    
DSM International B.V. [Member] | Accounts Payable [Member]                
Due to Related Parties, Current, Total       2,100,000   2,100,000    
DSM International B.V. [Member] | Accrued and Other Current Liabilities [Member]                
Due to Related Parties, Current, Total       600,000   600,000    
DSM International B.V. [Member] | License [Member]                
Revenue from Contract with Customer, Including Assessed Tax 27,500,000         54,700,000    
DSM International B.V. [Member] | Royalty [Member]                
Revenue from Contract with Customer, Including Assessed Tax $ 15,000,000              
Line of Credit Facility, Maximum Borrowing Capacity             $ 25,000,000  
Early Payment Discount   $ 700,000            
DSM International B.V. [Member] | Royalty [Member] | Forecast [Member]                
Revenue from Contract with Customer, Including Assessed Tax         $ 8,100,000      
DSM International B.V. [Member] | Manufactured Product, Other [Member]                
Contract with Customer, Liability, Total       24,400,000   24,400,000    
Contract with Customer, Liability, Current       3,300,000   3,300,000    
Contract with Customer, Liability, Noncurrent       $ 21,000,000   $ 21,000,000    
[1] The balance in contract liabilities at December 31, 2017 represents deferred revenue, current prior to the Company's adoption of ASC 606, "Revenue".
[2] The balance in contract liabilities, current at December 31, 2017 represents deferred revenue, current prior to the Company's adoption of ASC 606, "Revenue".
[3] Revision to accounting for equity received in satisfaction of a customer receivable.
[4] The balances in contract liabilities, noncurrent are included in other noncurrent liabilities on the consolidated balance sheets.
[5] Ginkgo partnership obligation and promissory note issuance recorded as reduction to revenue and correction of errors in recording revenue from non-cash consideration.
XML 40 R80.htm IDEA: XBRL DOCUMENT v3.19.3
Note 11 - Related Party Transactions - Related Party Revenues (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Revenues $ 63,604 $ 127,671
Customers Other Than Related Parties [Member]    
Revenues [1] 52,551 66,729
DSM International B.V. [Member]    
Revenues 10,711 59,651
Total [Member]    
Revenues 342 (200)
Novvi LLC [Member]    
Revenues 1,491
Related Parties [Member]    
Revenues 11,053 60,942
Renewable Products [Member]    
Revenues 33,598 42,370
Renewable Products [Member] | Customers Other Than Related Parties [Member]    
Revenues [1] 33,238 41,079
Renewable Products [Member] | DSM International B.V. [Member]    
Revenues 18
Renewable Products [Member] | Total [Member]    
Revenues 342 (200)
Renewable Products [Member] | Novvi LLC [Member]    
Revenues 1,491
Renewable Products [Member] | Related Parties [Member]    
Revenues 360 1,291
Licenses and Royalties [Member]    
Revenues 7,658 48,703
Licenses and Royalties [Member] | Customers Other Than Related Parties [Member]    
Revenues [1] 1,700 (9,269)
Licenses and Royalties [Member] | DSM International B.V. [Member]    
Revenues 5,958 57,972
Licenses and Royalties [Member] | Total [Member]    
Revenues
Licenses and Royalties [Member] | Novvi LLC [Member]    
Revenues
Licenses and Royalties [Member] | Related Parties [Member]    
Revenues 5,958 57,972
Grants and Collaborations [Member]    
Revenues 22,348 36,598
Grants and Collaborations [Member] | Customers Other Than Related Parties [Member]    
Revenues [1] 17,613 34,919
Grants and Collaborations [Member] | DSM International B.V. [Member]    
Revenues 4,735 1,679
Grants and Collaborations [Member] | Total [Member]    
Revenues
Grants and Collaborations [Member] | Novvi LLC [Member]    
Revenues
Grants and Collaborations [Member] | Related Parties [Member]    
Revenues $ 4,735 $ 1,679
[1] Licenses and royalties revenues is negative for 2017 due to the $13.1 million reversal of cumulative inception to date revenue as a result of entering into the 2017 Ginkgo Partnership Agreement. See Note 10. Revenue Recognition.
XML 41 R70.htm IDEA: XBRL DOCUMENT v3.19.3
Note 9 - Commitments and Contingencies - Future Minimum Payments for Lease Obligations (Details) - USD ($)
$ in Thousands
Dec. 31, 2018
Dec. 31, 2017
Capital leases 2019 $ 513  
Operating leases 2019 10,416  
Total lease obligations 2019 10,929  
Capital leases 2020 198  
Operating leases 2020 7,932  
Total lease obligations 2020 8,130  
Capital leases 2021 1  
Operating leases 2021 7,226  
Total lease obligations 2021 7,227  
Capital leases 2022  
Operating leases 2022 7,399  
Total lease obligations 2022 7,399  
Capital leases 2023  
Operating leases 2023 3,034  
Total lease obligations 2023 3,034  
Capital leases thereafter  
Operating leases thereafter  
Total lease obligations thereafter  
Total future minimum capital lease payments 712  
Total future minimum operating lease payments 36,007  
Total future minimum lease payments 36,719  
Less: amount representing interest (33)  
Present value of minimum lease payments 679  
Less: current portion (484)  
Long-term portion $ 195 $ 217
XML 43 R74.htm IDEA: XBRL DOCUMENT v3.19.3
Note 10 - Revenue Recognition - Revenue in Connection With Significant Revenue Agreement (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Revenues $ 63,604 $ 127,671
Renewable Products [Member]    
Revenues 33,598 42,370
Licenses and Royalties [Member]    
Revenues 7,658 48,703 [1]
Grants and Collaborations [Member]    
Revenues 22,348 36,598
All Other Customers [Member]    
Revenues 24,877 29,537
All Other Customers [Member] | Renewable Products [Member]    
Revenues 25,775 18,742
All Other Customers [Member] | Licenses and Royalties [Member]    
Revenues 12
All Other Customers [Member] | Grants and Collaborations [Member]    
Revenues (898) 10,783
Significant Revenue Agreement [Member]    
Revenues 38,727 98,134
Significant Revenue Agreement [Member] | Renewable Products [Member]    
Revenues 7,823 23,628
Significant Revenue Agreement [Member] | Licenses and Royalties [Member]    
Revenues 7,658 48,691
Significant Revenue Agreement [Member] | Grants and Collaborations [Member]    
Revenues 23,246 25,815
Significant Revenue Agreement [Member] | DSM International B.V. [Member]    
Revenues 10,711 59,651
Significant Revenue Agreement [Member] | DSM International B.V. [Member] | Renewable Products [Member]    
Revenues 18
Significant Revenue Agreement [Member] | DSM International B.V. [Member] | Licenses and Royalties [Member]    
Revenues 5,958 57,972
Significant Revenue Agreement [Member] | DSM International B.V. [Member] | Grants and Collaborations [Member]    
Revenues 4,735 1,679
Significant Revenue Agreement [Member] | Firmenich [Member]    
Revenues 11,144 16,623
Significant Revenue Agreement [Member] | Firmenich [Member] | Renewable Products [Member]    
Revenues 3,727 9,621
Significant Revenue Agreement [Member] | Firmenich [Member] | Licenses and Royalties [Member]    
Revenues 1,700 1,199
Significant Revenue Agreement [Member] | Firmenich [Member] | Grants and Collaborations [Member]    
Revenues 5,717 5,803
Significant Revenue Agreement [Member] | DARPA [Member]    
Revenues 8,436 12,333
Significant Revenue Agreement [Member] | DARPA [Member] | Renewable Products [Member]    
Revenues
Significant Revenue Agreement [Member] | DARPA [Member] | Licenses and Royalties [Member]    
Revenues
Significant Revenue Agreement [Member] | DARPA [Member] | Grants and Collaborations [Member]    
Revenues 8,436 12,333
Significant Revenue Agreement [Member] | Givaudan International, SA [Member]    
Revenues 8,436 7,950
Significant Revenue Agreement [Member] | Givaudan International, SA [Member] | Renewable Products [Member]    
Revenues 4,078 1,950
Significant Revenue Agreement [Member] | Givaudan International, SA [Member] | Licenses and Royalties [Member]    
Revenues
Significant Revenue Agreement [Member] | Givaudan International, SA [Member] | Grants and Collaborations [Member]    
Revenues 4,358 6,000
Significant Revenue Agreement [Member] | Nenter & Co., Inc. [Member]    
Revenues 14,690
Significant Revenue Agreement [Member] | Nenter & Co., Inc. [Member] | Renewable Products [Member]    
Revenues 12,057
Significant Revenue Agreement [Member] | Nenter & Co., Inc. [Member] | Licenses and Royalties [Member]    
Revenues 2,633
Significant Revenue Agreement [Member] | Nenter & Co., Inc. [Member] | Grants and Collaborations [Member]    
Revenues
Significant Revenue Agreement [Member] | Ginkgo Bioworks, Inc. [Member]    
Revenues (13,113)
Significant Revenue Agreement [Member] | Ginkgo Bioworks, Inc. [Member] | Renewable Products [Member]    
Revenues
Significant Revenue Agreement [Member] | Ginkgo Bioworks, Inc. [Member] | Licenses and Royalties [Member]    
Revenues (13,113)
Significant Revenue Agreement [Member] | Ginkgo Bioworks, Inc. [Member] | Grants and Collaborations [Member]    
Revenues
[1] Ginkgo partnership obligation and promissory note issuance recorded as reduction to revenue and correction of errors in recording revenue from non-cash consideration.
XML 44 R84.htm IDEA: XBRL DOCUMENT v3.19.3
Note 12 - Stock-based Compensation - Employee Service Share-based Compensation, Allocation of Recognized Period Costs (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Allocated share-based compensation expense $ 9,190 $ 6,265
Research and Development Expense [Member]    
Allocated share-based compensation expense 1,797 2,204
Selling, General and Administrative Expenses [Member]    
Allocated share-based compensation expense $ 7,393 $ 4,061
XML 45 R18.htm IDEA: XBRL DOCUMENT v3.19.3
Note 9 - Commitments and Contingencies
12 Months Ended
Dec. 31, 2018
Notes to Financial Statements  
Contingencies Disclosure [Text Block]
9.
Commitments and Contingencies
 
Lease Obligations
 
The Company leases certain facilities and finances certain equipment under operating and capital leases, respectively. Operating leases include leased facilities, and capital leases include leased equipment (see Note
3,
"Balance Sheet Details"). The Company recognizes rent expense on a straight-line basis over the noncancelable lease term and records the difference between cash rent payments and the recognition of rent expense as a deferred rent liability. Where leases contain escalation clauses, rent abatements, and/or concessions, such as rent holidays and landlord or tenant incentives or allowances, the Company applies them as straight-line rent expense over the lease term. The Company has noncancelable operating lease agreements for office, research and development, and manufacturing space that expire at various dates, with the latest expiration in
May 2023.
Rent expense under operating leases was
$5.8
million and
$5.1
million for the years ended
December 
31,
2018
and
2017,
respectively.
 
Future minimum payments under the Company's lease obligations as of
December 
31,
2018,
are as follows:
 
Years Ending December 31

(In thousands)
  Capital
Leases
  Operating
Leases
  Total Lease
Obligations
2019   $
513
    $
10,416
    $
10,929
 
2020    
198
     
7,932
     
8,130
 
2021    
1
     
7,226
     
7,227
 
2022    
     
7,399
     
7,399
 
2023    
     
3,034
     
3,034
 
Thereafter    
     
     
 
Total future minimum payments    
712
    $
36,007
    $
36,719
 
Less: amount representing interest    
(33
)    
 
     
 
 
Present value of minimum lease payments    
679
     
 
     
 
 
Less: current portion    
(484
)    
 
     
 
 
Long-term portion   $
195
     
 
     
 
 
 
Guarantor Arrangements
 
The Company has agreements whereby it indemnifies its executive officers and directors for certain events or occurrences while the executive officer or director is serving in his or her official capacity. The indemnification period remains enforceable for the executive officer's or director’s lifetime. The maximum potential amount of future payments the Company could be required to make under these indemnification agreements is unlimited; however, the Company has a director and officer insurance policy that limits its exposure and enables the Company to recover a portion of any future payments. As a result of its insurance policy coverage, the Company believes the estimated fair value of these indemnification agreements is minimal. Accordingly, the Company had
no
liabilities recorded for these agreements as of
December 
31,
2018
and
2017.
 
The GACP Term Loan Facility (see Note
5,
"Debt" and Note
16,
“Subsequent Events”) is collateralized by
first
-priority liens on substantially all of the Company's assets, including Company intellectual property. Certain of the Company’s subsidiaries have guaranteed the Company’s obligations under the GACP Term Loan Facility.
 
The Nikko Note is collateralized by a
first
-priority lien on
10%
of the Aprinnova JV interests owned by the Company, as discussed in Note
5,
"Debt".
 
Other Matters
 
Certain conditions
may
exist as of the date the financial statements are issued, which
may
result in a loss to the Company but will only be recorded when
one
or more future events occur or fail to occur. The Company's management assesses such contingent liabilities, and such assessment inherently involves an exercise of judgement. In assessing loss contingencies related to legal proceedings that are pending against and by the Company or unasserted claims that
may
result in such proceedings, the Company's management evaluates the perceived merits of any legal proceedings or unasserted claims as well as the perceived merits of the amount of relief sought or expected to be sought.
 
If the assessment of a contingency indicates that it is probable that a material loss has been incurred and the amount of the liability can be estimated, then the estimated liability would be accrued in the Company's financial statements. If the assessment indicates that a potential material loss contingency is
not
probable but is reasonably possible, or is probable but cannot be reasonably estimated, then the nature of the contingent liability, together with an estimate of the range of possible loss if determinable and material would be disclosed. Loss contingencies considered to be remote by management are generally
not
disclosed unless they involve guarantees, in which case the guarantee would be disclosed.
 
On
April 3, 2019,
a securities class action complaint was filed against Amyris and our CEO, John G. Melo, and former CFO (and current Chief Business Officer), Kathleen Valiasek, in the U.S. District Court for the Northern District of California. The complaint seeks unspecified damages on behalf of a purported class that would comprise all persons and entities that purchased or otherwise acquired our securities between
March 15, 2018
and
March 19, 2019.
The complaint alleges securities law violations based on statements and omissions made by the Company during such period. Subsequent to the filing of the securities class action complaint described above, on
June 21, 2019,
a purported shareholder derivative complaint was filed in the U.S. District Court for the Northern District of California (Bonner v. Doerr, et al., Case
No.
4:19
-cv-
03621
) based on similar allegations to those made in the securities class action complaint described above. The derivative complaint names Amyris, Inc. as a nominal defendant and names a number of the Company’s current and former officers and directors as additional defendants. The lawsuit seeks to recover, on the Company's behalf, unspecified damages purportedly sustained by the Company in connection with allegedly misleading statements and/or omissions made in connection with the Company’s securities filings. The derivative complaint also seeks a series of changes to the Company’s corporate governance policies, restitution to the Company from the individual defendants, and an award of attorneys’ fees. These cases are in the initial pleadings stage. We believe the complaints lack merit, and intend to defend ourselves vigorously. Given the early stage of these proceedings, it is
not
yet possible to reliably determine any potential liability that could result from these matters.
 
The Company is subject to disputes and claims that arise or have arisen in the ordinary course of business and that have
not
resulted in legal proceedings or have
not
been fully adjudicated. Such matters that
may
arise in the ordinary course of business are subject to many uncertainties and outcomes are
not
predictable with reasonable assurance and therefore an estimate of all the reasonably possible losses cannot be determined at this time. Therefore, if
one
or more of these legal disputes or claims resulted in settlements or legal proceedings that were resolved against the Company for amounts in excess of management’s expectations, the Company’s consolidated financial statements for the relevant reporting period could be materially adversely affected.
XML 46 R14.htm IDEA: XBRL DOCUMENT v3.19.3
Note 5 - Debt
12 Months Ended
Dec. 31, 2018
Notes to Financial Statements  
Debt Disclosure [Text Block]
5.
Debt
 
December 31,

(In thousands)
  2018   2017
    Principal   Unamortized
Debt
(Discount)
Premium
  Change in
Fair Value
  Net   Principal   Unamortized
Debt
(Discount)
Premium
  Net
Convertible notes payable    
 
     
 
     
 
     
 
     
 
   
(As Restated, Note 2)
   
 
 
6% convertible notes due 2021   $
60,000
    $
    $
(2,082
)   $
57,918
    $
    $
 
  $
 
2015 Rule 144A convertible notes    
37,887
     
(2,413
)    
     
35,474
     
37,887
     
(9,458
)
   
28,429
 
2014 Rule 144A convertible notes    
24,004
     
(867
)    
     
23,137
     
24,004
     
(3,170
)
   
20,834
 
August 2013 financing convertible notes    
4,415
     
(70
)    
     
4,345
     
4,009
     
(2,126
)
   
1,883
 
December 2017 convertible notes    
     
     
     
     
5,000
     
(25
)
   
4,975
 
     
126,306
     
(3,350
)    
(2,082
)    
120,874
     
70,900
     
(14,779
)
   
56,121
 
Related party convertible notes payable                                                        
2014 Rule 144A convertible notes    
24,705
     
(1,038
)    
     
23,667
     
24,705
     
(3,784
)
   
20,921
 
August 2013 financing convertible notes    
     
     
     
     
21,711
     
897
 
   
22,608
 
R&D note    
     
     
     
     
3,700
     
(18
)
   
3,682
 
     
24,705
     
(1,038
)    
     
23,667
     
50,116
     
(2,905
)
   
47,211
 
Loans payable and credit facilities                                                        
GACP term loan facility    
36,000
     
(1,349
)    
     
34,651
     
     
 
   
 
Ginkgo note    
12,000
     
(4,047
)    
     
7,953
     
12,000
     
(4,862
)
   
7,138
 
Other loans payable    
4,910
     
(1,047
)    
     
3,863
     
6,463
     
(1,277
)
   
5,186
 
Senior secured loan facility    
     
     
     
     
28,566
     
(253
)
   
28,313
 
Other credit facilities    
     
     
     
     
381
     
 
   
381
 
     
52,910
     
(6,443
)    
     
46,467
     
47,410
     
(6,392
)
   
41,018
 
Related party loans payable                                                        
DSM note    
25,000
     
(6,311
)    
     
18,689
     
25,000
     
(8,039
)
   
16,961
 
February 2016 private placement    
     
     
     
     
2,000
     
 
   
2,000
 
Other DSM loan    
     
     
     
     
393
     
 
   
393
 
     
25,000
     
(6,311
)    
     
18,689
     
27,393
     
(8,039
)
   
19,354
 
Total debt   $
228,921
    $
(17,142
)   $
(2,082
)    
209,697
    $
195,819
    $
(32,115
)
   
163,704
 
Less: current portion    
 
     
 
     
 
     
(147,677
)    
 
     
 
 
   
(56,943
)
Long-term debt, net of current portion    
 
     
 
     
 
    $
62,020
     
 
     
 
 
  $
106,761
 
 
Future minimum payments under the debt agreements as of
December 
31,
2018
are as follows:
 
Years ending December 31
(In thousands)
  Convertible Notes   Loans
Payable and Credit Facilities
  Related Party Convertible Notes   Related Party Loans Payable and Credit Facilities   Total
2019   $
134,368
    $
10,219
    $
25,508
    $
2,500
    $
172,595
 
2020    
     
9,981
     
     
2,500
     
12,481
 
2021    
     
34,740
     
     
27,521
     
62,261
 
2022    
     
13,417
     
     
     
13,417
 
2023    
     
367
     
     
     
367
 
Thereafter    
     
2,200
     
     
     
2,200
 
Total future minimum payments    
134,368
     
70,924
     
25,508
     
32,521
     
263,321
 
Less: amount representing interest
(1)
   
(7,368
)    
(18,014
)    
(803
)    
(7,521
)    
(33,706
)
Less: future conversion of accrued interest to principal    
(694
)    
     
     
     
(694
)
Present value of minimum debt payments    
126,306
     
52,910
     
24,705
     
25,000
     
228,921
 
Less: current portion of debt principal    
(126,306
)    
(3,829
)    
(24,705
)    
     
(154,840
)
Noncurrent portion of debt principal   $
    $
49,081
    $
    $
25,000
    $
74,081
 
______________
 
(
1
)
Excluding net debt discount of
$17.1
million that will be amortized to interest expense over the term of the debt.
 
Convertible Notes Payable
 
6%
Convertible Notes Due
2021
 
On
December 6, 2018,
the Company entered into a securities purchase agreement to issue and sell
$60.0
million in aggregate principal amount of senior convertible notes (the
6%
Convertible Notes Due
2021
) that are convertible into shares of the Company’s common stock. The securities purchase agreement prohibits the Company, subject to certain exceptions, from (i) disposing of any common stock or securities convertible into or exchangeable for shares of common stock during the period commencing on
December 6, 2018
and continuing through the later of (A) the date
90
days after
December 10, 2018
and (B) the date
30
days after the Registration Statement (as defined below) is declared effective and (ii) effecting or entering into an agreement to effect any issuance involving a variable rate transaction for so long as the
6%
Convertible Notes Due
2021
remain outstanding.
 
The closing of the issuance and sale of the
6%
Convertible Notes Due
2021
occurred on
December 10, 2018,
for net proceeds, after deducting offering expenses payable by the Company and placement agent and advisory fees, of
$56.2
million.
 
The
6%
Convertible Notes Due
2021
are general unsecured obligations of the Company. Unless earlier converted or redeemed, the
6%
Convertible Notes Due
2021
will mature on the
third
anniversary of issuance, subject to the rights of the holders to extend the maturity date in certain circumstances. The
6%
Convertible Notes Due
2021
are convertible from time to time, at the election of the holders, into shares of common stock at an initial conversion price of
$6.32
per share. The conversion price is subject to adjustment in the event of any stock split, reverse stock split, recapitalization, reorganization or similar transaction. The Company has the option, upon prior notice to the holders, to settle any conversion of the
6%
Convertible Notes Due
2021
in cash.
 
The
6%
Convertible Notes Due
2021
are payable in equal monthly installments beginning
April 1, 2019 (
each, an Installment Date), in either cash at
108%
of such installment amount or, at the Company’s option, subject to the satisfaction of certain equity conditions (the Equity Conditions), in shares of common stock at a discount to the then-current market price, subject to a price floor (the Installment Conversion Price). The holders have the right, upon notice to the Company, to defer all or any portion of any installment amount to a future Installment Date. In addition, if the Company elects to pay any installments in shares of common stock, the holders of the
6%
Convertible Notes Due
2021
have the right to accelerate amounts outstanding under their
6%
Convertible Notes Due
2021
during such month up to an aggregate of
three
times the relevant installment amount.
 
The
6%
Convertible Notes Due
2021
bear interest at a rate of
6%
per annum, payable quarterly until the
first
Installment Date, and then at each Installment Date thereafter. Interest on the
6%
Convertible Notes Due
2021
may
be paid in either cash or, at the Company’s option, subject to the satisfaction of the Equity Conditions, shares of common stock at the Installment Conversion Price. The Company elected to make the interest payment due
January 1, 2019
in cash.
 
The
6%
Convertible Notes Due
2021
contain customary terms and covenants, including (i) a restriction on the Company’s ability to incur additional indebtedness, (ii) certain events of default, after which the holders
may
require the Company to redeem all or any portion of their
6%
Convertible Notes Due
2021
in cash at a price equal to the greater of (A)
125%
of the amount being redeemed and (B) the intrinsic value of the shares of common stock underlying the amount being redeemed, and (iii) certain other events, after which the holders
may
convert all or any portion of the
6%
Convertible Notes Due
2021
at a discount to the Installment Conversion Price.
 
In the event of a Fundamental Transaction (as defined in the
6%
Convertible Notes Due
2021
), holders of the
6%
Convertible Notes Due
2021
may
require the Company to redeem all or any portion of their
6%
Convertible Notes Due
2021
at a price equal to the greater of (i)
125%
of the amount being redeemed and (ii) a premium to the intrinsic value of the shares of Common Stock underlying the amount being redeemed.
 
Notwithstanding the foregoing, the holders will
not
have the right to convert any portion of a
6%
Convertible Note Due
2021,
and the Company will
not
have the option to pay any amount in shares of common stock, if (a) the holder, together with its affiliates, would beneficially own in excess of
4.99%
(or such other percentage as determined by the holder and notified to the Company in writing,
not
to exceed
9.99%,
provided that any increase of such percentage will
not
be effective until
61
days after notice thereof) of the number of shares of common stock outstanding immediately after giving effect to such conversion or payment, as applicable (the Ownership Limitation), or (b) the aggregate number of shares issued with respect to the
6%
Convertible Notes Due
2021
(and any other transaction aggregated for such purpose) after giving effect to such conversion or payment, as applicable, would exceed
15,271,047
shares of common stock (the Exchange Cap), unless the Company has obtained prior stockholder approval to issue shares in excess of the Exchange Cap. In the event that (i) the Company is prohibited from issuing any shares of common stock under the
6%
Convertible Notes Due
2021
as a result of the Ownership Limitation (other than in connection with a conversion of
6%
Convertible Notes Due
2021
), such shares shall be held in abeyance (and the related principal amount of the
6%
Convertible Notes Due
2021
reinstated) until the holder shall notify the Company and elect to receive such shares without exceeding the Ownership Limitation, and (ii) the Company is prohibited from issuing any shares of common stock under the
6%
Convertible Notes Due
2021
as a result of the Exchange Cap, the Company will pay cash in lieu of any shares that would otherwise be deliverable in excess of the Exchange Cap.
 
In connection with the offering of the
6%
Convertible Notes Due
2021,
the Company entered into a registration rights agreement, dated
December 10, 2018,
with the purchasers of the
6%
Convertible Notes Due
2021,
pursuant to which the Company agreed to file a registration statement (the Registration Statement) with the Securities and Exchange Commission (the SEC) registering the resale of all of the shares of common stock issuable pursuant to the terms of the
6%
Convertible Notes Due
2021
(the Registrable Securities) under the Securities Act of
1933,
as amended (the Securities Act), within
30
days following
December 10, 2018,
and to have the Registration Statement declared effective by the SEC by the date that is
60
days after
December 10, 2018.
In the event that the Registration Statement is
not
filed or declared effective within the foregoing time frames, or if thereafter, subject to certain exceptions, the Registration Statement is
not
effective for any reason or the prospectus contained therein is
not
available for use by the holders, Company shall pay to each holder an amount in cash equal to
2%
of such holder’s original principal amount of Notes on the date of such failure and thereafter on every
30
day anniversary thereof until such failure is cured or
no
longer prevents the holders from freely disposing of their Registrable Securities. The Company filed the Registration Statement on
January 8, 2019,
and it went effective on
February 7, 2019.
 
The Company has elected to account for the
6%
Convertible Notes Due
2021
at fair value pursuant to U.S. GAAP, as of the issuance date. Management believes that the fair value option better reflects the underlying economics of the
6%
Convertible Notes Due
2021,
which contain multiple embedded derivatives. Under the fair value election, changes in fair value will be reported in the consolidated statements of operations as "Gain (loss) from change in fair value of debt" in each reporting period subsequent to the issuance of the
6%
Convertible Notes Due
2021.
For the year ended
December 
31,
2018,
the Company recorded a gain of
$2.1
million, which is shown as Change in Fair Value in the table at the beginning of this Note
4.
See Note
4,
"Fair Value Measurement" for information about the assumptions that the Company used to measure the fair value of the
6%
Convertible Notes Due
2021.
 
In
May,
June
and
July 2019,
the Company exchanged the
6%
Convertible Notes Due
2021
for new senior convertible notes and warrants to purchase common stock. See Note
16,
“Subsequent Events” for additional information.
 
2015
Rule
144A
Convertible Notes
 
In
October 2015,
the Company sold
$57.6
million aggregate principal amount of
9.50%
convertible senior notes due
2019
(the
2015
Rule
144A
Convertible Notes) to certain qualified institutional buyers in a private placement. Net proceeds from the offering were
$54.4
million after payment of offering expenses and placement agent fees, which together are treated as a debt discount and are being amortized over the remaining loan term using the effective interest method. The Company used
$18.3
million of the net proceeds to repurchase
$22.9
million aggregate principal amount of outstanding
2014
Rule
144A
Convertible Notes as discussed below. The
2015
Rule
144A
Convertible Notes bear interest at a rate of
9.50%
per year, payable semiannually in arrears on
April 15
and
October 15
of each year. Interest on the
2015
Rule
144A
Convertible Notes is payable, at the Company's option, entirely in cash or entirely in common stock valued at
92.5%
of a market-based price. The Company elected to make the
April 15, 2016
and
2017
and
October 15, 2018
interest payments in shares of common stock and the
October 15, 2016
and
2017
and
April 15, 2018
interest payments in cash. The
2015
Rule
144A
Convertible Notes matured on
April 15, 2019.
See Note
16,
"Subsequent Events".
 
The
2015
Rule
144A
Convertible Notes are convertible into shares of the Company's common stock at a conversion rate of
61.7246
shares per
$1,000
principal amount of
2015
Rule
144A
Convertible Notes (which conversion rate is subject to adjustment in certain circumstances), representing an effective conversion price of approximately
$16.20
per share as of
December 
31,
2018.
If converted prior to maturity, noteholders are entitled to receive a payment (the Early Conversion Payment) equal to the present value of the remaining scheduled payments of interest on the
2015
Rule
144A
Convertible Notes being converted through
April 15, 2019,
computed using a discount rate of
0.75%.
The Company
may
make the Early Conversion Payment, at its election, either in cash or, subject to certain conditions, in common stock valued at
92.5%
of a market-based price. Through
December 
31,
2018,
the Company has elected to make each Early Conversion Payment in shares of common stock.
 
In
January 2017,
the Company issued an additional
$19.1
million in aggregate principal amount of
2015
Rule
144A
Convertible Notes (the Additional
2015
Rule
144A
Convertible Notes) in exchange for the cancellation of
$15.3
million in aggregate principal amount of other outstanding convertible promissory notes of the Company, with the same terms as the
2015
Rule
144A
Convertible Notes; provided, that the aggregate number of shares issued with respect to the Additional
2015
Rule
144A
Convertible Notes (and any other transaction aggregated for such purpose) cannot exceed
3,652,935
shares of common stock without prior stockholder approval. The exchange was accounted for as an extinguishment of debt, resulting in a
$0.1
million gain in the year ended
December 31, 2017.
 
In
May 2017,
the Company exchanged
$3.7
million in aggregate principal amount of
2015
Rule
144A
Convertible Notes for shares of its Series B
17.38%
Convertible Preferred Stock and warrants to purchase common stock, as described in more detail in Note
7,
“Stockholders’ Deficit”. The exchange was accounted for as an extinguishment of debt, resulting in a
$2.0
million loss in the year ended
December 31, 2017.
 
On
April 16, 2019,
the Company repaid the
2015
Rule
144A
Convertible Notes in full in cash. See Note
16,
“Subsequent Events”. 
 
2014
Rule
144A
Convertible Notes
 
In
May 2014,
the Company sold
$75.0
million in aggregate principal amount of
6.50%
Convertible Senior Notes due
2019
(the
2014
Rule
144A
Convertible Notes) to qualified institutional buyers in a private placement. The net proceeds from the offering were
$72.0
million after payment of initial purchaser discounts and offering expenses, which together are treated as a debt discount and are being amortized over the remaining loan term. The Company used
$9.7
million of the net proceeds to repay convertible notes previously issued to an affiliate of Total S.A. (together with its affiliates, Total), representing the amount of
2014
Rule
144A
Convertible Notes purchased by Total. Certain of the Company's affiliated entities (including Total) purchased
$24.7
million in aggregate principal amount of
2014
Rule
144A
Convertible Notes. The
2014
Rule
144A
Convertible Notes bear interest at an annual rate of
6.5%,
payable semiannually in arrears on
May 15
and
November 15
of each year in cash. The
2014
Rule
144A
Convertible Notes mature on
May 
15,
2019,
unless earlier converted or repurchased. 
 
The
2014
Rule
144A
Convertible Notes are convertible into shares of the Company's common stock at a conversion rate of
17.8073
shares per
$1,000
principal amount of
2014
Rule
144A
Convertible Notes (which conversion rate is subject to adjustment in certain circumstances), representing an effective conversion price of approximately
$56.16
per share as of
December 
31,
2018.
 
In
May 2017,
the Company exchanged
$3.4
million in aggregate principal amount of
2014
Rule
144A
Convertible Notes for shares of its Series B
17.38%
Convertible Preferred Stock and warrants to purchase common stock, as described in more detail in Note
7,
“Stockholders’ Deficit". The exchange was accounted for as an extinguishment, resulting in a
$1.8
million loss for the year ended
December 31, 2017.
 
In
May 2019,
the Company exchanged a portion of the
2014
Rule
144A
Convertible Notes, representing
$38.2
million aggregate principal amount of
2014
Rule
144A
Convertible Notes, for shares of common stock, warrants to purchase common stock and a new senior convertible note (see Note
16,
“Subsequent Events” for additional information) and repaid the remaining portion of the
2014
Rule
144A
Convertible Notes in cash at maturity.
 
August 2013
Financing Convertible Notes
 
In
August 2013,
the Company entered into a Securities Purchase Agreement (the
August 2013
SPA) with Total and Temasek to sell up to
$73.0
million in convertible notes in private placements (the
August 2013
Financing or the Tranche Notes). The
August 2013
SPA provided for the
August 2013
Financing to be divided into
two
tranches, each with differing closing conditions. The Tranche I Notes were due
sixty
months from the date of issuance (
October 16, 2018).
Interest accrued on the Tranche I Notes at
5%
per
six
months, compounded semiannually, and was payable in kind by adding to the principal or in cash. Through maturity, the Company elected to pay interest on the Tranche I Notes in kind. The Tranche I Notes totaling
$15.2
million of principal and accrued interest matured and were repaid in full by conversion into shares of common stock on
October 16, 2018
pursuant to the Maturity Treatment Agreement terms (see “Related Party Convertible Notes Payable -
August 2013
Financing Convertible Notes” below). Upon conversion of the Tranche I Notes, the Company recognized a
$10.9
million loss upon extinguishment of debt in
2018.
See the "Maturity Treatment Agreement" section below for details of the impact of that agreement on the Tranche Notes.
 
The Tranche II Notes are due
sixty
months from the date of issuance (
January 15, 2019).
Interest accrues on the Tranche II Notes at
10%
per annum, compounded annually, and is payable in kind by adding to the principal or in cash. Through
December 
31,
2018,
the Company has elected to repay interest on the Tranche II Notes in kind. On
November 8, 2018,
the Company repaid in full the Tranche II Notes held by Total totaling
$9.8
million of principal and accrued interest by conversion into shares of common stock pursuant to the Maturity Treatment Agreement terms (see “Related Party Convertible Notes Payable -
August 2013
Financing Convertible Notes” below). Upon conversion of the Tranche II Notes held by Total, the Company recognized a
$6.5
million loss upon extinguishment of debt.
 
In
August 2018,
in connection with certain amendments to the
August 2017
Vivo Cash Warrants (see Note
7,
“Stockholders' Deficit”), the conversion price of the Tranche Notes I and II was reduced from
$5.2977
per share to
$4.40
per share. As of
December 
31,
2018,
the conversion price of the remaining Tranche II Notes held by Wolverine Flagship Fund Trading Limited (Wolverine) is
$4.40
per share (which conversion price is subject to adjustment in certain circumstances, including certain price-based anti-dilution adjustments). The
August 2013
SPA and the Tranche Notes contain customary terms, covenants and restrictions, including a limit on the Company’s debt, subject to certain exceptions and waivers, of the greater of
$200
million or
50%
of its consolidated total assets and the Company’s secured debt of the greater of
$125
million or
30%
of its consolidated total assets. The
August 2013
SPA also requires the Company to obtain the consent of the holders of a majority of these notes before completing any change of control transaction or purchasing assets in
one
transaction or in a series of related transactions in an amount greater than
$20.0
million, in each case while any Tranche Notes are outstanding. In addition, the Tranche Notes contain certain events of default after which the Tranche Notes
may
become due and payable immediately.
 
On
January 14, 2019,
Wolverine agreed to waive payment of the Tranche II Note held by Wolverine at maturity until
July 15, 2019
in exchange for a cash waiver fee, payable on or prior to
July 15, 2019,
of
$0.6
million. On
July 2, 2019,
the Company and Wolverine entered into an exchange agreement whereby the parties agreed to extinguish the Tranche II Note held by Wolverine in exchange for
1,767,632
shares of common stock and a warrant to purchase
1,080,000
shares of common stock. See Note
16,
“Subsequent Events” for additional information.
 
Maturity Treatment Agreement
 
In
July 2015,
the Company entered into an Exchange Agreement (the
2015
Exchange Agreement) with Total and Temasek pursuant to which Temasek exchanged
$71.0
million in principal amount of outstanding Tranche Notes and Total exchanged
$70.0
million in principal amount of outstanding convertible notes for shares of the Company's common stock at a price of
$34.50
per share (
2015
Exchange). At the closing of the
2015
Exchange, the Company, Total and Temasek also entered into a Maturity Treatment Agreement dated
July 29, 2015,
pursuant to which Total and Temasek agreed to convert any Tranche Notes or
2014
144A
Notes held by them that were
not
canceled in the
2015
Exchange (Remaining Notes) into shares of the Company's common stock in accordance with the terms of such Remaining Notes at or prior to maturity, provided that certain events of default had
not
occurred with respect to the applicable Remaining Notes. In
May 2017,
the Company entered into separate letter agreements with each of Total and Temasek, pursuant to which the Company agreed that the Remaining Notes consisting of
2014
144A
Notes held by Total (
$9.7
million in principal amount as of
December 
31,
2017
) and Temasek (
$10.0
million in principal amount as of
December 
31,
2017
) would
no
longer be subject to mandatory conversion at or prior to the maturity of such Remaining Notes. Accordingly, the Company will be required to pay any portion of such Remaining Notes that remain outstanding at maturity in cash in accordance with the terms of such Remaining Notes. As of
December 
31,
2017,
after giving effect to such letter agreements, Temasek did
not
hold any Remaining Notes and Total held
$21.8
million in principal amount of Remaining Notes (consisting of Tranche Notes), which Remaining Notes were converted to common stock in
October
and
November 2018
pursuant to the terms of the Maturity Treatment Agreement (see below under "Related Party Convertible Notes Payable -
August 2013
Financing Convertible Notes" for more information). The
2015
Exchange Agreement contains customary terms, covenants and restrictions, including a limit on the Company’s debt of the greater of
$200
million or
50%
of its consolidated total assets and the Company’s secured debt of the greater of
$125
million or
30%
of its consolidated total assets, subject to certain exceptions.
 
December 2017
Convertible Note
 
In
December 2017,
the Company issued and sold a convertible note under an
April 2017
securities purchase agreement in the principal amount of
$5.0
million with a maturity date of
June 1, 2018,
for proceeds to the Company of
$5.0
million. The Company identified certain embedded feature that required bifurcation, but the fair value of these derivative features was
$0,
due primarily to the short-term maturity of the note and a significant out of the money conversion price at issuance and through the maturity date. The Company elected to pay each installment in cash, and the note was repaid in full in
May 2018.
 
Related Party Convertible Notes Payable
 
August 2013
Financing Convertible Notes
 
Certain of the
August 2013
Financing Convertible Notes were held by related parties; see Note
11,
"Related Party Transactions" for details.
 
On
October 16, 2018,
the Tranche I Notes held by Total totaling
$15.2
million of principal and accrued interest reached maturity and were converted into
3,448,821
shares of common stock. Upon conversion of the Tranche I Notes, the Company recognized a
$10.9
million loss upon extinguishment of debt.
 
On
November 8, 2018,
Total converted its Tranche II Notes totaling
$9.8
million of principal and accrued interest, which were scheduled to mature on
January 15, 2019,
into shares of common stock. In connection with such conversion, the Company agreed to pay Total future interest on the Tranche II Notes being converted up to, but excluding, the maturity date for such notes, which interest was converted by Total into common stock at the conversion price for the Tranche II Notes. As a result of such conversion, the Tranche II Notes held by Total converted into
2,226,105
shares of common stock. Upon conversion of the Tranche II Notes held by Total, the Company recognized a
$6.5
million loss upon extinguishment of debt.
 
2014
Rule
144A
Convertible Notes
 
Certain of the
2014
Rule
144A
Convertible Notes are held by related parties. See Note
11,
"Related Party Transactions" for details.
 
R&D Note
 
In
March 2016,
as a result of the restructuring of the Company’s fuels joint venture with Total, Total Amyris BioSolutions B.V., the Company issued to Total an unsecured convertible note (the R&D Note) in the principal amount of
$3.7
million, representing the remaining portion of the
$105.0
million convertible note facility between the Company and Total initially established in
2012.
In
March
and
May 2018,
the Company and Total amended the R&D Note to extend the maturity to
May 31, 2018
and
July 2, 2018,
respectively, with accrued and unpaid interest payable on
March 31, 2018,
May 31, 2018
and
July 2, 2018.
On
July 2, 2018,
the Company repaid the R&D Note in full.
 
Loans Payable and Credit Facilities
 
GACP
Term Loan Facility
 
On
June 29, 2018,
the Company, certain of the Company’s subsidiaries and GACP Finance Co., LLC (GACP) entered into a Loan and Security Agreement (the LSA) to borrow a
$36.0
million secured term loan (the GACP Term Loan Facility). The LSA also provides for an incremental secured term loan facility in an aggregate principal amount of up to
$35.0
million (the Incremental GACP Term Loan Facility and, together with the GACP Term Loan Facility, the GACP Term Loan Facilities), subject to certain conditions and approvals, to fund the construction of a custom-built manufacturing facility in Brazil. The majority of the net proceeds from the GACP Term Loan Facility were used to repay all amounts outstanding under the Senior Secured Loan Facility between the Company and Stegodon described below. The remaining net proceeds were used on
July 2, 2018
to repay amounts outstanding under the R&D Note at maturity, as described above.
 
Loans under the GACP Term Loan Facilities have a maturity date of
July 1, 2021;
provided, that if the Company has
not
(i) met certain financial conditions on or prior to
January 7, 2019
or (ii) refinanced the
2015
Rule
144A
Convertible Notes and
2014
Rule
144A
Convertible Notes with indebtedness that has a maturity date which is later than
July 1, 2021
or converted such notes into equity prior to
January 12, 2019,
then the maturity date will be
January 12, 2019.
See Note
16,
“Subsequent Events” for additional information about the waiver of this provision. The GACP Term Loan Facilities will amortize beginning on
July 1, 2019
in quarterly installments equal to
2.5%
of the original loan amounts, with the remaining principal balance payable on the maturity date. Loans under the GACP Term Loan Facilities initially accrued interest at a rate per annum equal to the sum of (i) the greater of (A) the U.S. prime rate as reported in the Wall Street Journal and (B)
4.0%,
plus (ii)
6.25%,
payable monthly. The GACP Term Loan Facilities are guaranteed by the subsidiaries of the Company party to the LSA and collateralized by
first
-priority liens on substantially all the Company’s and such subsidiaries’ assets, including intellectual property, subject to certain exceptions. The LSA includes customary terms, covenants and restrictions, including mandatory prepayments upon the occurrence of certain events, including asset sales, casualty events, incurrence of additional indebtedness and borrowing base deficiencies, subject to certain exceptions and reinvestment rights. The LSA contains certain financial covenants that include quarterly minimum revenues, minimum liquidity amounts and a minimum asset coverage ratio.
 
The Company paid origination fees at closing equal to
4%,
or
$1.4
million, of the funded amount of the GACP Term Loan Facility and other closing costs totaling
$0.2
million, plus an agency fee of
$25,000
per quarter during the term of the GACP Term Loan Facilities. The
$1.6
million of issuance costs will be amortized using the effective interest method over the expected
3
-year loan term.
 
In
November 2018,
the Company and GACP amended the LSA to reduce the minimum revenue requirement for the
two
fiscal quarters ending
December 31, 2018
in exchange for an increase in optional prepayment fees, an increase in the minimum liquidity amount and an increase in the base interest rate per annum, from the sum of (i) the greater of (A) the prime rate as reported in the Wall Street Journal or (B) 
4.0%
plus (ii) 
6.25%
to the sum of (i) the greater of (A) the prime rate as reported in the Wall Street Journal or (B) 
4.0%
plus (ii) 
8.25%.
In
December 2018,
the Company and GACP further amended the LSA to exclude certain intellectual property licensed to DSM from the loan collateral (see Note
10,
“Revenue Recognition” for more information) in exchange for a further increase in the base interest rate per annum, from the sum of (i) the greater of (A) the prime rate as reported in the Wall Street Journal or (B) 
4.0%
plus (ii) 
8.25%
to the sum of (i) the greater of (A) the prime rate as reported in the Wall Street Journal or (B) 
4.75%
plus (ii) 
9.00%.
 
In
April 2019, (
i) GACP provided a waiver to the Company for breaches of all covenant violations under the GACP loan and security agreement (LSA) occurring prior to, as of and after
December 31, 2018
through
April 8, 2019,
and (ii) GACP sold and assigned the loans under the LSA and all documents and assets related thereto to Foris Ventures, LLC (Foris). Subsequently, Foris provided a waiver to the Company for breaches of certain covenants under the LSA through
June 30, 2020
and amended the financial covenants under the LSA to provide more favorable compliance terms and conditions. See Note
16,
"Subsequent Events" for additional information.
 
Senior Secured Loan Facility
 
In
March 2014,
the Company entered into a Loan and Security Agreement (the LSA) with Hercules Technology Growth Capital, Inc. to make available to the Company a secured loan facility (the Senior Secured Loan Facility) in an initial aggregate principal amount of up to
$25.0
million. The LSA was subsequently amended in
June 2014,
March 2015
and
November 2015
to (i) extend additional credit facilities to the Company in an aggregate amount of up to
$31.0
million, of which
$16.0
million was drawn by the Company, (ii) extend the maturity date of the loans, and (iii) remove, add and/or modify certain covenants and agreements under the LSA.
 
In
June 2016,
Hercules transferred and assigned its rights and obligations under the Senior Secured Loan Facility to Stegodon Corporation (Stegodon), an affiliate of Ginkgo Bioworks, Inc. (Ginkgo).
 
In
March
and
May 2018,
the Company and Stegodon amended the LSA to extend the date for a
$5.5
million principal payment to
May 31, 2018
and
July 2, 2018,
respectively. Under the amendments, the interest rate from
April 1, 2018
through the date of such
$5.5
million principal payment would be the previously agreed interest rate plus
5.0%.
 
On
June 29, 2018,
the Company repaid the Senior Secured Loan Facility in full.
 
Ginkgo Note
 
In
November 2017,
the Company issued an unsecured promissory note in the principal amount of
$12.0
million to Ginkgo (the
November 2017
Ginkgo Note) in connection with the termination of the Ginkgo Collaboration Agreement and the execution of a new partnership agreement (the Ginkgo Partnership Agreement), which is described in Note
10,
"Revenue Recognition". The
November 2017
Ginkgo Note bears interest at
10.5%
per annum, payable monthly, and has a maturity date of
October 19, 2022.
The
November 2017
Ginkgo Note
may
be prepaid in full without penalty or premium at any time, provided that certain payments have been made under the Company’s partnership agreement with Ginkgo. The
November 2017
Ginkgo Note also contains customary terms, covenants and restrictions, including certain events of default after which the note
may
become due and payable immediately. The Company recorded the
$7.0
million present value of the
November 2017
Ginkgo Note as a note payable liability, and the remaining
$5.0
million was recorded as a debt discount which is being accreted to interest expense over the loan term using the effective interest method. Also, the Company concluded that while
no
cash was received from Ginkgo under the
November 2017
Ginkgo Note, the transaction represents consideration payable to a former customer and the present value of the note payable obligation should be recorded as a reduction of cumulative revenue recognized to date from Ginkgo in the period the
November 2017
Ginkgo Note was executed. As a result, the Company recorded a
$7.0
million reduction of license revenues as of
December 31, 2017.
See Note
10,
"Revenue Recognition" for additional information.
 
Other Loans Payable
 
Nikko Note:
 In
December 2016,
in connection with the Company's formation of its cosmetics joint venture (the Aprinnova JV) with Nikko Chemicals Co., Ltd. (Nikko) made a loan to the Company in the principal amount of
$3.9
million and the Company issued a promissory note (the Nikko Note) to Nikko in an equal principal amount. The proceeds of the Nikko Note were used to satisfy the Company's remaining liabilities related to the Company's purchase of a manufacturing facility in Leland, North Carolina and related assets in
December 2016,
including liabilities under a promissory note in the principal amount of
$3.5
million issued in connection therewith. The Nikko Note (i) bears interest at
5%
per year, (ii) has a term of
13
years, (iii) is payable in equal monthly installments of principal and interest beginning on
January 1, 2017
and (iv) is secured by a
first
-priority lien on
10%
of the Aprinnova JV interests owned by the Company. In addition, (i) the Company repaid
$400,000
of the Nikko Note in equal monthly installments of
$100,000
as required on
January 1, 2017,
February 1, 2017,
March 1, 2017
and
April 1, 2017
and (ii) the Company is required to repay the Nikko Note with any profits distributed to the Company by the Aprinnova JV, beginning with the distributions for the
fourth
fiscal year of the Aprinnova JV, until the Nikko Note is fully repaid. The Nikko Note
may
be prepaid in full or in part at any time without penalty or premium. The Nikko Note contains customary terms and provisions, including certain events of default after which the Nikko Note
may
become due and payable immediately.
 
Aprinnova Working Capital Loans: 
In
February 2017,
in connection with the formation of the Aprinnova JV in
December 2016,
Nikko made a working capital loan to the Aprinnova JV in the principal amount of
$1.5
million and received a promissory note from the Aprinnova JV in an equal amount (the First Aprinnova Note). The First Aprinnova Note was repayable in
$375,000
installments plus accrued interest on
May 1, 2017,
August 1, 2017,
November 1, 2017
and
February 1, 2018.
The First Aprinnova Note was fully repaid in
January 2018.
In
August 2017,
Nikko made a
second
working capital loan to the Aprinnova JV in the principal amount of
$1.5
million and received a promissory note from the Aprinnova JV in an equal amount (the Second Aprinnova Note). The Second Aprinnova Note is payable in full on
August 1, 2019,
with interest payable quarterly. Both notes bear interest at
2.75%
per annum. Effective
July 31, 2019,
the Company and Nikko agreed to extend the term of the Second Aprinnova Note to
August 1, 2020.
See Note
16,
"Subsequent Events".
 
Related Party Loans Payable
 
DSM Note
 
In
December 2017,
the Company and DSM entered into a credit agreement (the DSM Credit Agreement) to make available to the Company an unsecured credit facility of
$25.0
million. On
December 28, 2017,
the Company borrowed
$25.0
million under the DSM Credit Agreement, representing the entire amount available thereunder, and issued a promissory note to DSM in an equal principal amount (the DSM Note). The Company used the proceeds of the amounts borrowed under the DSM Credit Agreement to repay all outstanding principal under a promissory note in the principal amount of
$25
million issued to Guanfu Holding Co., Ltd. in
December 2016 (
the Guanfu Note). Given multiple elements in the arrangements with DSM, the Company fair valued the DSM Note to determine the arrangement consideration that should be allocated to the DSM Note. The fair value of the DSM Note was discounted using a Company specific weighted average cost of capital rate that resulted in a debt discount of
$8.0
million. The debt discount is being amortized over the loan term using the effective interest method.
 
The DSM Note (i) is an unsecured obligation of the Company, (ii) matures on
December 31, 2021
and (iii) accrues interest from and including
December 28, 2017
at
10%
per annum, payable quarterly. The DSM Note
may
be prepaid in full or in part at any time without penalty or premium. In addition, the Company is required to use certain payments received by the Company from DSM under the Value Sharing Agreement (see Note
10,
“Revenue Recognition”) to repay amounts outstanding under the DSM Credit Agreement. The DSM Credit Agreement and the DSM Note contain customary terms, covenants and restrictions, including certain events of default after which the DSM Note
may
become due and payable immediately.
 
February 2016
Private Placement
 
In
February 2016,
the Company issued and sold
$20.0
million in aggregate principal amount of promissory notes (the
February 2016
Notes), as well as warrants to purchase an aggregate of
190,477
shares of the Company's common stock, exercisable at a price of
$0.15
per share as of
December 
31,
2018
(the
February 2016
Warrants), resulting in aggregate proceeds to the Company of
$20.0
million, in a private placement to certain existing stockholders of the Company that are affiliated with members of the Company's Board of Directors (the Board): Foris Ventures, LLC (Foris, an entity affiliated with director John Doerr of Kleiner Perkins Caufield & Byers, a current stockholder, and an owner of greater than
five
percent of the Company’s outstanding common stock), which purchased
$16.0
million aggregate principal amount of the
February 2016
Notes and warrants to purchase
152,381
shares of the Company's common stock; Naxyris S.A. (Naxyris, an investment vehicle owned by Naxos Capital Partners SCA Sicar; director Carole Piwnica is Director of NAXOS UK, which is affiliated with Naxos Capital Partners SCA Sicar, and was designated as a director of the Company by Naxyris), which purchased
$2.0
million aggregate principal amount of the
February 2016
Notes and warrants to purchase
19,048
shares of the Company's common stock; and Biolding Investment SA (Biolding, a fund affiliated with director HH Sheikh Abdullah bin Khalifa Al Thani, who was designated as a director of the Company by Biolding), which purchased
$2.0
million aggregate principal amount of the
February 2016
Notes and warrants to purchase
19,048
shares of the Company's common stock.
 
The
February 2016
Notes bore interest at
13.50%
per annum and had an initial maturity date of
May 15, 2017.
In
May 2017,
the
February 2016
Notes purchased by Foris and Naxyris were exchanged for shares of the Company’s Series B
17.38%
Convertible Preferred Stock and warrants to purchase common stock; see Note
7,
“Stockholders’ Deficit”.
 
In
May 2017,
the Company and Biolding amended the
February 2016
Note issued to Biolding (the Biolding Note) to extend the maturity of the Biolding Note to
November 15, 2017,
and on
November 13, 2017,
the Company and Biolding further amended the Biolding Note to extend the maturity to
December 31, 2017.
The Company paid the Biolding Note in full on
January 2, 2018.
 
The
February 2016
Warrants each have
five
-year terms. The
February 2016
Warrants purchased by Naxyris were fully exercised in the year ended
December 31, 2017,
and a gain of
$0.1
million was recorded in earnings. As of
December 
31,
2018,
none
of the
171,429
February 2016
Warrants purchased by Foris or Biolding have been exercised.
 
For information regarding related party loans payable subsequent to
December 31, 2018,
see Note
16,
“Subsequent Events”.
 
Letters of Credit
 
In
June 2012,
the Company entered into a letter of credit agreement for
$1.0
million under which it provided a letter of credit to the landlord for its headquarters in Emeryville, California in order to cover the security deposit on the lease. This letter of credit is secured by a certificate of deposit. Accordingly, the Company has
$1.0
million of restricted cash, noncurrent in connection with this arrangement as of
December 
31,
2018
and
2017.
XML 47 R10.htm IDEA: XBRL DOCUMENT v3.19.3
Note 1 - Basis of Presentation and Summary of Significant Accounting Policies
12 Months Ended
Dec. 31, 2018
Notes to Financial Statements  
Significant Accounting Policies [Text Block]
1.
Basis of Presentation and Summary of Significant Accounting Policies
 
Business Description
 
Amyris, Inc. (Amyris or the Company) is a leading industrial biotechnology company that applies its technology platform to engineer, manufacture and sell high performance, natural, sustainably-sourced products into the Health & Wellness, Clean Beauty, and Flavor & Fragrance markets. The Company's proven technology platform enables the Company to rapidly engineer microbes and use them as catalysts to metabolize renewable, plant-sourced sugars into large volume, high-value ingredients. The Company's biotechnology platform and industrial fermentation process replace existing complex and expensive manufacturing processes. The Company has successfully used its technology to develop and produce several distinct molecules at commercial volumes.
 
Going Concern
 
The Company has incurred significant operating losses since its inception and expects to continue to incur losses and negative cash flows from operations for at least the next
12
months following the issuance of the financial statements. As of
December 
31,
2018,
the Company had negative working capital of
$119.5
million and an accumulated deficit of
$1.5
billion.
 
As of
December 
31,
2018,
the Company's debt (including related party debt), net of deferred discount and issuance costs of
$17.1
million and a change in fair value of
$2.1
million, totaled
$209.7
million, of which
$147.7
million is classified as current. The Company's debt agreements contain various covenants, including certain restrictions on the Company's business that could cause the Company to be at risk of defaults, such as restrictions on additional indebtedness, material adverse effect and cross default clauses. A failure to comply with the covenants and other provisions of the Company’s debt instruments, including any failure to make a payment when required, would generally result in events of default under such instruments, which could permit acceleration a substantial portion of such indebtedness. If such indebtedness is accelerated, it would generally also constitute an event of default under the Company’s other outstanding indebtedness, permitting acceleration of a substantial portion of such other outstanding indebtedness. At
December 31, 2018,
the Company failed to meet certain covenants in connection with the GACP Term Loan Facility (see Note
5,
“Debt”), including those associated with minimum revenue and minimum liquidity requirements. In
April 2019, (
i) GACP provided a waiver to the Company for breaches of all covenant violations under the GACP loan and security agreement (LSA) occurring prior to, as of and after
December 31, 2018
through
April 8, 2019,
and (ii) GACP sold and assigned the loans under the LSA and all documents and assets related thereto to Foris Ventures, LLC (Foris). Subsequently, Foris provided a waiver to the Company for breaches of certain covenants under the LSA through
June 30, 2020
and amended the financial covenants under the LSA to provide more favorable compliance terms and conditions. See Note
16,
"Subsequent Events" for additional information.
 
Cash and cash equivalents of
$45.4
million as of
December 
31,
2018
are
not
sufficient to fund expected future negative cash flows from operations and cash debt service obligations through
September 
30,
2020.
These factors raise substantial doubt about the Company’s ability to continue as a going concern within
one
year after the date that these financial statements are issued. The consolidated financial statements do
not
include any adjustments that might result from the outcome of this uncertainty. The Company's ability to continue as a going concern will depend, in large part, on its ability to achieve positive cash flows from operations during the
12
months from the date of this filing, and refinance or extend other existing debt maturities occurring later in
2019,
all of which are uncertain and outside the control of the Company. Further, the Company's operating plan for
2019
contemplates a significant reduction in its net operating cash outflows as compared to the year ended
December 
31,
2018,
resulting from (i) revenue growth from sales of existing and new products with positive gross margins, (ii) reduced production costs as a result of manufacturing and technical developments, and (iii) an increase in cash inflows from collaborations and grants. If the Company is unable to complete these actions, it expects to be unable to meet its operating cash flow needs and its obligations under its existing debt facilities. This could result in an acceleration of its obligation to repay all amounts outstanding under those facilities, and the Company
may
be forced to obtain additional equity or debt financing, which
may
not
occur timely or on reasonable terms, if at all, and/or liquidate its assets. In such a scenario, the value received for assets in liquidation or dissolution could be significantly lower than the value reflected in these financial statements. The Company has in the past, including in
July 2019,
had certain of its debt instruments accelerated for failure to make a payment when due. While we have been able to cure these defaults to date to avoid additional cross-acceleration, we
may
not
be able to cure such a default promptly in the future.
 
On
September 16, 2019,
the Company failed to pay an aggregate of
$63.6
million of outstanding principal and accrued interest on the Second Exchange Note when due. The failure resulted in an event of default under the Second Exchange Note and also triggered cross-defaults under other debt instruments of the Company which permitted the holders of such indebtedness to accelerate the amounts owing under such instruments. The Company subsequently received waivers from substantially all holders of such other debt instruments to waive the right to accelerate. As a result, the indebtedness with respect to which the Company has obtained such waivers continues to be classified as long-term on the Company’s balance sheet.  The indebtedness reflected by the Second Exchange Note continues to be classified as a current liability on the Company’s balance sheet. In addition, as a result of the payment default, the conversion price of the Second Exchange Note is subject to adjustment in accordance with the terms of the Second Exchange Note.
 
The Company does
not
currently have sufficient funds to repay the amounts outstanding under the Second Exchange Note. To date, negotiations with the holder of the Second Exchange Note have
not
been successful, and there can be
no
assurance that a favorable outcome for the Company will be reached. The Company has executed a term sheet with an existing investor for a term loan, the proceeds of which would be used to repay a portion of the Second Exchange Note. However, there can be
no
assurance that the Company will be able to obtain such financing on its expected timeline, or on acceptable terms, if at all. Even if the Company does obtain such financing, it will
not
have sufficient funds to repay the Second Exchange Note in full without obtaining additional financing, which the Company is attempting to source. The consolidated financial statements do
not
include any adjustments that might result from the outcome of this uncertainty.
 
Basis of Consolidation
 
The accompanying consolidated financial statements have been prepared in accordance with the accounting principles generally accepted in the United States (U.S. GAAP). The consolidated financial statements include the accounts of Amyris, Inc. and its wholly-owned and partially-owned subsidiaries in which the Company has a controlling interest after elimination of all significant intercompany accounts and transactions.
 
Investments and joint venture arrangements are assessed to determine whether the terms provide economic or other control over the entity requiring consolidation of the entity. Entities controlled by means other than a majority voting interest are referred to as variable-interest entities (VIEs) and are consolidated when Amyris has both the power to direct the activities of the VIE that most significantly impact its economic performance and the obligation to absorb losses or the right to receive benefits that could potentially be significant to the entity. For any investment or joint venture in which (i) the Company does
not
have a majority ownership interest, (ii) the Company possesses the ability to exert significant influence and (iii) the entity is
not
a VIE for which the Company is considered the primary beneficiary, the Company accounts for the investment or joint venture using the equity method. Following the adoption of ASU
2016
-
01
on
January 1, 2018
described in more detail below (which was applicable to the Company on a prospective basis), equity investments in which the Company does
not
exert significant influence and that do
not
have readily determinable fair values are measured at cost, adjusted for changes from observable market transactions, less impairment (“adjusted cost basis”). The Company evaluates its investments for impairment by considering a variety of factors, including the earnings capacity of the related investments. Fair value measurements for the Company’s equity investments are classified within Level
3
of the fair value hierarchy based on the nature of the fair value inputs. Realized and unrealized gains or losses are recognized in other income or expense.
 
Sale of Subsidiary and Entry into Commercial Agreements
 
On
December 28, 2017,
the Company completed the sale of all of the capital stock of its subsidiary Amyris Brasil, a wholly-owned subsidiary, to DSM Produtos Nutricionais Brasil S.A (DSM), a related party. Amyris Brasil owned and operated the Company’s production facility in Brotas, Brazil. The transaction resulted in a pretax gain of
$5.7
million from continuing operations in
2017,
which was further adjusted by a
$1.8
million loss in
2018
related to the final working capital adjustments between the Company and DSM. The transaction did
not
result in presenting Amyris Brasil as a discontinued operation in the consolidated financial statements, as the sale did
not
represent a strategic shift that will have a major effect on the Company’s operations and financial results due to the Company’s continuing commercial presence and reinvestment in a new production facility under construction in Brazil and its continuing Brazilian operation through Amyris Biotecnologia do Brasil Ltda. (formerly SMA Indústria Química Ltda.). The Company and DSM also entered into a series of commercial agreements and a credit agreement concurrently with the sale of Amyris Brasil. See Note
10,
“Revenue Recognition”, Note
11,
“Related Party Transactions”, Note
13,
“Divestiture” and Note
16,
“Subsequent Events” for further information.
 
Use of Estimates and Judgements
 
The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates, judgements and assumptions that affect the reported amounts of assets and liabilities, disclosures of contingent assets and liabilities at the date of the financial statements, and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates, and such differences
may
be material to the consolidated financial statements.
 
Significant Accounting Policies
 
Cash and Cash Equivalents
 
The Company considers all highly liquid investments purchased with an original or remaining maturity of
three
months or less at the date of purchase to be cash equivalents. Cash and cash equivalents are maintained with various financial institutions.
 
Inventories
 
Inventories, which consist of farnesene-derived products, flavors and fragrances ingredients and clean beauty products, are stated at the lower of actual cost or net realizable value and are categorized as finished goods, work in process or raw material inventories. The Company evaluates the recoverability of its inventories based on assumptions about expected demand and net realizable value. If the Company determines that the cost of inventories exceeds their estimated net realizable value, the Company records a write-down equal to the difference between the cost of inventories and the estimated net realizable value. If actual net realizable values are less favorable than those projected by management, additional inventory write-downs
may
be required that could negatively impact the Company's operating results. If actual net realizable values are more favorable, the Company
may
have favorable operating results when products that have been previously written down are sold in the normal course of business. The Company also evaluates the terms of its agreements with its suppliers and establishes accruals for estimated losses on adverse purchase commitments as necessary, applying the same lower of cost or net realizable value approach that is used to value inventory. Cost is computed on a weighted-average basis.
 
Property, Plant and Equipment, Net
 
Property, plant and equipment are recorded at cost. Depreciation and amortization are computed straight-line based on the estimated useful lives of the related assets, ranging from
3
to
15
years for machinery, equipment and fixtures, and
15
years for buildings. Leasehold improvements are amortized over their estimated useful lives or the period of the related lease, whichever is shorter.
 
The Company expenses costs for maintenance and repairs and capitalizes major replacements, renewals and betterments. For assets retired or otherwise disposed, both cost and accumulated depreciation are eliminated from the asset and accumulated depreciation accounts, and gains or losses related to the disposal are recorded in the statement of operations for the period.
 
Impairment
 
Long-lived assets that are held and used by the Company are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount of such assets
may
not
be recoverable. Determination of recoverability of long-lived assets is based on an estimate of the undiscounted future cash flows resulting from the use of the asset and its eventual disposition. Measurement of an impairment loss for long-lived assets that management expects to hold and use is based on the difference between the fair value of the asset and its carrying value. Long-lived assets to be disposed of are reported at the lower of carrying amount or fair value less costs to sell.
 
Recoverable Taxes from Brazilian Government Entities
 
Recoverable taxes from Brazilian government entities represent value-added taxes paid on purchases in Brazil, which are reclaimable from the Brazilian tax authorities, net of reserves for amounts estimated
not
to be recoverable.
 
Fair Value Measurements
 
The carrying amounts of certain financial instruments, such as cash equivalents, short-term investments, accounts receivable, accounts payable and accrued liabilities, approximate fair value due to their relatively short maturities.
 
The Company measures the following financial assets and liabilities at fair value:
Freestanding and bifurcated derivatives in connection with certain debt and equity financings; and
6%
Convertible Notes Due
2021
(see Note
4,
"Fair Value Measurement", Note
5,
"Debt" and Note
16,
“Subsequent Events”), for which the Company has elected fair value accounting
 
Fair value is based on the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants. Where available, fair value is based on or derived from observable market prices or other observable inputs. Where observable prices or inputs are
not
available, valuation techniques are applied. These valuation techniques involve some level of management estimation and judgement, the degree of which is dependent on the price transparency for the instruments or market and the instruments’ complexity.
 
Changes to the inputs used in these valuation models have a significant impact on the estimated fair value of the
6%
Convertible Notes Due
2021
and the Company's embedded and freestanding derivatives. For example, a decrease (increase) in the estimated credit spread for the Company results in an increase (decrease) in estimated fair value. Conversely, a decrease (increase) in the stock price results in a decrease (increase) in estimated fair value.
 
The changes during
2018
and
2017
in the fair values of the bifurcated compound embedded derivatives are primarily related to the change in price of the Company's common stock and are reflected in the consolidated statements of operations as “Gain (loss) from change in fair value of derivative instruments”.
 
For debt instruments for which the Company has
not
elected fair value accounting, fair value is based on the present value of expected future cash flows and assumptions about the then-current market interest rates as of the reporting period and the creditworthiness of the Company. Most of the Company's debt is carried on the consolidated balance sheet on a historical cost basis net of unamortized discounts and premiums, because the Company has
not
elected the fair value option of accounting. However, for the
6%
Notes Due
2021,
the Company elected fair value accounting, so that balances reported for that debt instrument represent fair value as of each balance sheet date; see Note
4,
"Fair Value Measurement", for additional information. Changes in fair value of the
6%
Convertible Notes Due
2021
are reflected in the consolidated statements of operations as “Gain (loss) from change in fair value of debt”.
 
For all debt instruments, including any for which the Company has elected fair value accounting, the Company classifies interest that has been accrued during each period as Interest expense on the consolidated statements of operations.
 
Derivatives
 
Embedded derivatives that are required to be bifurcated from the underlying debt instrument (i.e., host) are accounted for and valued as separate financial instruments. The Company has evaluated the terms and features of its convertible notes payable and convertible preferred stock and identified compound embedded derivatives requiring bifurcation and accounting at fair value, using the valuation techniques mentioned in the
Fair Value Measurements
section of this Note, because the economic and contractual characteristics of the embedded derivatives met the criteria for bifurcation and separate accounting due to the instruments containing conversion options, certain “make-whole interest” provisions, down-round conversion price adjustment provisions and/or conversion rate adjustments.
 
Cash warrants and anti-dilution warrants issued in conjunction with the convertible debt and equity financings are freestanding financial instruments which are also classified as derivative liabilities.
 
Noncontrolling Interest
 
Noncontrolling interests represent the portion of net income (loss), net assets and comprehensive income (loss) that is
not
allocable to the Company, in situations where the Company consolidates its equity investment in a joint venture for which there are other owners. The amount of noncontrolling interest is comprised of the amount of such interests at the date of the Company's original acquisition of an equity interest in a joint venture, plus the other shareholders' share of changes in equity since the date the Company made an investment in the joint venture.
 
Concentration of Credit Risk
 
Financial instruments that potentially subject the Company to a concentration of credit risk consist primarily of cash and cash equivalents, short-term investments and accounts receivable. The Company places its cash equivalents and investments (primarily certificates of deposits) with high credit quality financial institutions and, by policy, limits the amount of credit exposure with any
one
financial institution. Deposits held with banks
may
exceed the amount of insurance provided on such deposits. The Company has
not
experienced any losses on its deposits of cash and cash equivalents and short-term investments.
 
The Company performs ongoing credit evaluation of its customers, does
not
require collateral, and maintains allowances for potential credit losses on customer accounts when deemed necessary.
 
Customers representing
10%
or greater of accounts receivable were as follows:
 
As of December 31,   2018   2017
Customer B    
24
%    
10
%
Customer C    
19
%    
15
%
Customer G    
11
%    
**
Customer A (related party)    
**
     
38
%
______________
** Less than
10%
 
Customers representing
10%
or greater of revenue were as follows:
 
Years Ended December 31,   2018   2017
        (As Restated, Note 2)
Customer A (related party)    
17
%    
46
%
Customer B    
18
%    
13
%
Customer C    
13
%    
**
 
Customer D    
13
%    
**
 
Customer E    
**
     
11
%
Customer F     **       **  
 
______________
** Less than
10%
 
Revenue Recognition
 
Year ended
December 31, 2017
 
For the year ended
December 31, 2017,
the Company recognized revenue from the sale of renewable products, licenses of and royalties from intellectual property, and grants and collaborative research and development services. Revenue was recognized when all of the following criteria were met: persuasive evidence of an arrangement existed, delivery has occurred or services have been rendered, the fee was fixed or determinable, and collectability was reasonably assured. If sales arrangements contained multiple elements, the Company evaluated whether the components of each arrangement represent separate units of accounting.
 
 
Renewable Product Sales
 
The Company’s renewable product sales do
not
include rights of return, except for sales of Biossance products. Returns are only accepted if the product does
not
meet product specifications and such nonconformity is communicated to the Company within a set number of days of delivery. The Company offers a
two
-year standard warranty provision for squalane products, if the products do
not
meet Company-established criteria as set forth in the Company’s trade terms. The Company bases its return reserve on a historical rate of return for the Company’s squalane products. Revenues are recognized, net of discounts and allowances, once passage of title and risk of loss has occurred and contractually specified acceptance criteria have been met, provided all other revenue recognition criteria have also been met.
 
Licenses and Royalties
 
License fees for intellectual property transferred to other parties, representing non-refundable payments received at the time of signature of license agreements, are recognized as revenue upon signature of the license agreements when the Company has
no
significant future performance obligations and collectability of the fees is assured. Upfront payments received at the beginning of licensing agreements with future service obligations are deferred and recognized as revenue on a systematic basis over the period during which the related services are rendered and all obligations are performed.
 
Royalties from intellectual property licenses that allow Amyris's customers to use the Company’s intellectual property to produce and sell their products in which the Company shares in the profits are recognized in the period the royalty report is received.
 
Grants and Collaborative Research and Development Services
 
Revenues from collaborative research and development services are recognized as the services are performed consistent with the performance requirements of the contract. In cases where the planned levels of research and development services fluctuate over the research term, the Company recognizes revenues using the proportional performance method based upon actual efforts to date relative to the amount of expected effort to be incurred by us. When up-front payments are received and the planned levels of research and development services do
not
fluctuate over the research term, revenues are recorded on a ratable basis over the arrangement term, up to the amount of cash received. When up-front payments are received and the planned levels of research and development services fluctuate over the research term, revenues are recorded using the proportional performance method, up to the amount of cash received. Where arrangements include milestones that are determined to be substantive and at risk at the inception of the arrangement, revenues are recognized upon achievement of the milestone and is limited to those amounts whereby collectability is reasonably assured.
 
Grants are agreements that generally provide cost reimbursement for certain types of expenditures in return for research and development activities over a contractually defined period. Revenues from grants are recognized in the period during which the related costs are incurred, provided that the conditions under which the grants were provided have been met and only perfunctory obligations are outstanding.
 
Year ended
December 31, 2018
 
In accordance with a new revenue recognition standard that the Company adopted
January 1, 2018,
the Company recognizes revenue from the sale of renewable products, licenses of and royalties from intellectual property, and grants and collaborative research and development services. Revenue is measured based on the consideration specified in a contract with a customer, and transaction price is allocated utilizing stand-alone selling price. Revenue is recognized when, or as, the Company satisfies a performance obligation by transferring control over a product or service to a customer. The Company generally does
not
incur costs to obtain new contracts. The costs to fulfill a contract are expensed as incurred.
 
The Company accounts for a contract when it has approval and commitment to perform from both parties, the rights of the parties are identified, payment terms are established, the contract has commercial substance and collectability of the consideration is probable. Changes to contracts are assessed for whether they represent a modification or should be accounted for as a new contract. The Company considers the following indicators, among others, when determining if it is acting as a principal in the transaction and recording revenue on a gross basis: (i) the Company is primarily responsible for fulfilling the promise to provide the specified goods or service, (ii) the Company has inventory risk before the specified good or service has been transferred to a customer or after transfer of control to the customer and (iii) the Company has discretion in establishing the price for the specified good or service. If a transaction does
not
meet the Company's indicators of being a principal in the transaction, then the Company is acting as an agent in the transaction and the associated revenues are recognized on a net basis.
 
The Company’s significant contracts and contractual terms with its customers are presented in Note
10,
"Revenue Recognition".
 
The Company recognizes revenue when control has passed to the customer. The following indicators are evaluated in determining when control has passed to the customer: (i) the Company has a right to receive payment for the product or service, (ii) the customer has legal title to the product, (iii) the Company has transferred physical possession of the product to the customer, (iv) the customer has the significant risk and rewards of ownership of the product and (v) the customer has accepted the product. For most of the Company's renewable products customers, supply agreements between the Company and each customer indicate when transfer of title occurs.
 
In some cases, the Company
may
make a payment to a customer. When that occurs, the Company evaluates whether the payment is for a distinct good or service receivable from the customer. If the fair value of the goods or services receivable is greater than or equal to the amount paid to the customer, then the entire payment is treated as a purchase. If, on the other hand, the fair value of goods or services is less than the amount paid, then the difference is treated as a reduction in transaction price of the Company's sales to the customer.
 
Performance Obligations
 
A performance obligation is a promise in a contract to transfer a distinct good or service to the customer. A contract’s transaction price is allocated to each distinct performance obligation and recognized as revenue when, or as, the performance obligation is satisfied. The Company's contracts
may
contain multiple performance obligations if a promise to transfer the individual goods or services is separately identifiable from other promises in the contracts and, therefore, is considered distinct. For contracts with multiple performance obligations, the Company determines the standalone selling price of each performance obligation and allocates the total transaction price using the relative selling price basis.
 
The following is a description of the principal goods and services from which the Company generates revenue.
 
Renewable Product Sales
 
Revenues from renewable product sales are recognized as a distinct performance obligation on a gross basis as the Company is acting as a principal in these transactions, with the selling price to the customer recorded net of discounts and allowances. Revenues are recognized at a point in time when control has passed to the customer, which typically is upon the renewable products leaving the Company’s facilities with the
first
transportation carrier. The Company, on occasion,
may
recognize revenue under a bill and hold arrangement, whereby the customer requests and agrees to purchase product but requests delivery at a later date. Under these arrangements, control transfers to the customer when the product is ready for delivery, which occurs when the product is identified separately as belonging to the customer, the product is ready for shipment to the customer in its current form, and the Company does
not
have the ability to direct the product to a different customer. It is at this point that the Company has the right to receive payment, the customer obtains legal title, and the customer has the significant risks and rewards of ownership. The Company’s renewable product sales do
not
include rights of return, except for Biossance products, for which the Company estimates sales returns subsequent to sale and reduces revenue accordingly. For renewable products other than Biossance, returns are accepted only if the product does
not
meet product specifications and such nonconformity is communicated to the Company within a set number of days of delivery. The Company offers a
two
-year assurance-type warranty to replace squalane products that do
not
meet Company-established criteria as set forth in the Company’s trade terms. An estimate of the cost to replace the squalane products sold is made based on a historical rate of experience and recognized as a liability and related expense when the renewable product sale is consummated.
 
Licenses and Royalties
 
Licensing of Intellectual Property:
When the Company’s intellectual property licenses are determined to be distinct from the other performance obligations identified in the arrangement, revenue is recognized from non-refundable, up-front fees allocated to the license at a point in time when the license is transferred to the licensee and the licensee is able to use and benefit from the license. For intellectual property licenses that are combined with other promises, the Company utilizes judgment to assess the nature of the combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purposes of recognizing revenue from non-refundable, up-front-fees. The Company evaluates the measure of progress each reporting period and, if necessary, adjusts the measure of performance and related revenue recognized.
 
Royalties from Licensing of Intellectual Property:
The Company earns royalties from the licensing of its intellectual property whereby the licensee uses the intellectual property to produce and sell its products to its customers and the Company shares in the profits.
 
When the Company’s intellectual property license is the only performance obligation, or it is the predominant performance obligation in arrangements with multiple performance obligations, the Company applies the sales-based royalty exception which requires the Company to estimate the revenue that is recognized at a point in time when the licensee’s product sales occur. Estimates of sales-based royalty revenues are made using the most likely outcome method, which is the single amount in a range of possible amounts, using the best evidence available at the time, derived from the licensee’s historical sales volumes and sales prices of its products and recent commodity market pricing data and trends. Estimates are adjusted to actual or as new information becomes available.
 
When the Company’s intellectual property license is
not
the predominant performance obligation in arrangements with multiple performance obligations, the royalty represents variable consideration and is allocated to the transaction price of the predominant performance obligation which generally is the supply of renewable products to the Company's customers. Revenue is estimated and recognized at a point in time when the renewable products are delivered to the customer. Estimates of the amount of variable consideration to include in the transaction price are made using the expected value method, which is the sum of probability-weighted amounts in a range of possible amounts determined based on the cost to produce the renewable product plus a reasonable margin for the profit share. The Company only includes an amount of variable consideration in the transaction price to the extent it is probable that a significant reversal in the cumulative revenue recognized will
not
occur when the uncertainty associated with the variable consideration is subsequently resolved. Also, the transaction price is reduced for estimates of customer incentive payments payable by the Company for certain customer contracts.
 
Grants and Collaborative Research and Development Services
 
Collaborative Research and Development Services:
The Company earns revenues from collaboration agreements with customers to perform research and development services to develop new molecules using the Company’s technology and to scale production of the molecules for commercialization and use in the collaborator’s products. The collaboration agreements generally include providing the Company's collaboration partners with research and development services and with licenses to the Company’s intellectual property to use the technology underlying the development of the molecules and to sell its products that incorporate the technology. The terms of the Company's collaboration agreements typically include
one
or more of the following: advance payments for the research and development services that will be performed, nonrefundable upfront license payments, milestone payments to be received upon the achievement of the milestone events defined in the agreements, and royalty payments upon the commercialization of the molecules in which the Company shares in the customer’s profits.
 
Collaboration agreements are evaluated at inception to determine whether the intellectual property licenses represent distinct performance obligations separate from the research and development services. If the licenses are determined to be distinct, the non-refundable upfront license fee is recognized as revenue at a point in time when the license is transferred to the licensee and the licensee is able to use and benefit from the license while the research and development service fees are recognized over time as the performance obligations are satisfied. The research and development service fees represent variable consideration. Estimates of the amount of variable consideration to include in the transaction price are made using the expected value method, which is the sum of probability-weighted amounts in a range of possible amounts. The Company only includes an amount of variable consideration in the transaction price to the extent it is probable that a significant reversal in the cumulative revenue recognized will
not
occur when the uncertainty associated with the variable consideration is subsequently resolved. Revenue is recognized over time using either an input-based measure of labor hours expended or a time-based measure of progress towards the satisfaction of the performance obligations. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized.
 
Collaboration agreements that include milestone payments are evaluated at inception to determine whether the milestone events are considered probable of achievement, and estimates are made of the amount of the milestone payments to include in the transaction price using the most likely amount method which is the single amount in a range of possible amounts. If it is probable that a significant revenue reversal will
not
occur, the estimated milestone payment amount is included in the transaction price. Each reporting period, the Company re-evaluates the probability of achievement of the milestone events and any related constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative basis, which would affect collaboration revenues in the period of adjustment. Generally, revenue is recognized using an input-based measure of progress towards the satisfaction of the performance obligations which can be labor hours expended or time-based in proportion to the estimated total project effort or total projected time to complete. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized. Certain performance obligations are associated with milestones agreed between the Company and its customer. Revenue generated from the performance of services in accordance with these milestones is recognized upon confirmation from the customer that the milestone has been achieved. In these cases, amounts recognized are constrained to the amount of consideration received upon achievement of the milestone. 
 
The Company generally invoices its collaboration partners on a monthly or quarterly basis, or upon the completion of the effort or achievement of a milestone, based on the terms of each agreement. Deferred revenue arises from amounts received in advance of performing the research and development activities and is recognized as revenue in future periods as the performance obligations are satisfied.
 
Grants:
The Company earns revenues from grants with government agencies to, among other things, provide research and development services to develop molecules using the Company’s technology, and create research and development tools to improve the timeline and predictability for scaling molecules from proof of concept to market by reducing time and costs. Grants typically consist of research and development milestone payments to be received upon the achievement of the milestone events defined in the agreements.
 
The milestone payments are evaluated at inception to determine whether the milestone events are considered probable of achievement and estimates are made of the amount of the milestone payments to include in the transaction price using the most likely amount method which is the single amount in a range of possible amounts. If it is probable that a significant revenue reversal will
not
occur, the estimated milestone payment amount is included in the transaction price. Each reporting period, the Company re-evaluates the probability of achievement of the milestone events and any related constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative basis, which would affect grant revenues in the period of adjustment. Revenue is recognized over time using a time-based measure of progress towards the satisfaction of the performance obligations. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized.
 
Cost of Products Sold
 
Cost of products sold includes the production costs of renewable products, which include the cost of raw materials, in-house manufacturing labor and overhead, amounts paid to contract manufacturers, including amortization of tolling fees, and period costs including inventory write-downs resulting from applying lower of cost or net realizable value inventory adjustments. Cost of products sold also includes certain costs related to the scale-up of production. Shipping and handling costs charged to customers are recorded as revenues. Outbound shipping costs incurred are included in cost of products sold. Such charges were
not
material for any of the periods presented.
 
The Company recognizes deferred cost of products sold as an asset on the balance sheet when a cost is incurred in connection with a revenue performance obligation that will
not
be fulfilled until a future period.
 
Research and Development
 
Research and development costs are expensed as incurred and include costs associated with research performed pursuant to collaborative agreements and government grants, including internal research. Research and development costs consist of direct and indirect internal costs related to specific projects, as well as fees paid to others that conduct certain research activities on the Company’s behalf.
 
Debt Extinguishment
 
The Company accounts for the income or loss from extinguishment of debt in accordance with ASC
470,
Debt,
which indicates that for all extinguishment of debt, the difference between the reacquisition consideration and the net carrying amount of the debt being extinguished should be recognized as gain or loss when the debt is extinguished. Losses from debt extinguishment are shown in the consolidated statements of operations under "Other income (expense)" as "Loss upon extinguishment of debt".
 
Stock-based Compensation
 
The Company accounts for stock-based employee compensation plans under the fair value recognition and measurement provisions of U.S. GAAP. Those provisions require all stock-based payments to employees, including grants of stock options and restricted stock units (RSUs), to be measured using the grant-date fair value of each award. The Company recognizes stock-based compensation expense net of expected forfeitures over each award's requisite service period, which is generally the vesting term. Expected forfeiture rates are estimated based on the Company's historical experience. Stock-based compensation plans are described more fully in Note
12,
"Stock-based Compensation".
 
Income Taxes
 
The Company is subject to income taxes in the United States and foreign jurisdictions and uses estimates to determine its provisions for income taxes. The Company uses the asset and liability method of accounting for income taxes, whereby deferred tax asset or liability account balances are calculated at the balance sheet date using current tax laws and rates in effect for the year in which the differences are expected to affect taxable income.
 
Recognition of deferred tax assets is appropriate when realization of such assets is more likely than
not.
The Company recognizes a valuation allowance against its net deferred tax assets unless it is more likely than
not
that such deferred tax assets will be realized. This assessment requires judgement as to the likelihood and amounts of future taxable income by tax jurisdiction.
 
The Company applies the provisions of Financial Accounting Standards Board (FASB) guidance on accounting for uncertainty in income taxes. The Company assesses all material positions taken in any income tax return, including all significant uncertain positions, in all tax years that are still subject to assessment or challenge by relevant taxing authorities. Assessing an uncertain tax position begins with the initial determination of the position’s sustainability, and the tax benefit to be recognized is measured at the largest amount of benefit that is greater than
50
 percent likely of being realized upon ultimate settlement. As of each balance sheet date, unresolved uncertain tax positions must be reassessed, and the Company will determine whether (i) the factors underlying the sustainability assertion have changed and (ii) the amount of the recognized tax benefit is still appropriate. The recognition and measurement of tax benefits requires significant judgement, and such judgements
may
change as new information becomes available.
 
Foreign Currency Translation
 
The assets and liabilities of foreign subsidiaries, where the local currency is the functional currency, are translated from their respective functional currencies into U.S. dollars at the rates in effect at each balance sheet date, and revenue and expense amounts are translated at average rates during each period, with resulting foreign currency translation adjustments recorded in other comprehensive loss, net of tax, in the consolidated statements of stockholders’ deficit. As of 
December 
31,
2018
 and 
2017,
cumulative translation adjustment, net of tax, were
$43.3
million and 
$42.2
million, respectively.
 
Where the U.S. dollar is the functional currency, remeasurement adjustments are recorded in other income (expense), net in the accompanying consolidated statements of operations. Net losses resulting from foreign exchange transactions were 
$1.6
million and 
$0.4
million for the years ended 
December 
31,
2018
and
2017,
respectively and are recorded in other income (expense), net in the consolidated statements of operations.
 
New Accounting Standards or Updates Recently Adopted
 
During the year ended
December 
31,
2018
the Company adopted the following Accounting Standards Updates (ASUs):
 
Revenue Recognition
The Company adopted ASC
606,
Revenue from Contracts with Customers
, with a date of initial application of
January 1, 2018.
As a result, the Company has changed its accounting policy for revenue recognition as detailed above in “Significant Accounting Policies”. The Company applied ASC
606
using the modified retrospective approach by recognizing the cumulative effect of initially applying ASC
606
to all contracts
not
completed as of the date of adoption as an adjustment to the opening balance of accumulated deficit at
January 1, 2018.
Therefore, the comparative information has
not
been adjusted and continues to be reported under the legacy revenue recognition guidance of ASC
605,
"Revenue Recognition".
 
The Company applied ASC
606
using a practical expedient for contracts that were modified before the application date, which allowed the Company to determine an aggregate effect of all modifications that occurred before
January 1, 2018,
when determining the satisfied and unsatisfied performance obligations, the transaction price, and allocating that transaction price to the performance obligations instead of retrospectively restating the contracts for such contract modifications.
 
The cumulative effect of initially applying ASC
606
resulted in an increase to accumulated deficit at
January 1, 2018
of approximately
$0.8
million. The most significant change in accounting policy is the Company is now required to estimate royalty revenues from licenses of the Company’s intellectual property and recognize estimated royalty revenues at a point in time when the Company sells its renewable products to its customers (if the sales-based royalty exception does
not
apply) or when the licensee sells its products to its customer (if the sales-based royalty exception does apply).
 
The following table presents the amounts by which revenue is affected in the current reporting period by the application of ASC
606
as compared with the legacy guidance that was in effect before the accounting change.
 
    Year Ended December 31, 2018
(In thousands)   As Reported   Adjustments   Amounts Without the Adoption of ASC 606
Renewable products   $
33,598
    $
    $
33,598
 
Licenses and royalties    
7,658
     
5,094
     
12,752
 
Grants and collaborations    
22,348
     
(5,786
)    
16,562
 
Total revenue from all customers   $
63,604
    $
(692
)   $
62,912
 
 
Financial Instruments
In
January 2016,
the Financial Accounting Standards Board (FASB) issued ASU
2016
-
01,
 
Financial Instruments-Overall (Subtopic
825
-
10
): Recognition and Measurement of Financial Assets and Financial Liabilities
, which changes the accounting for equity investments, financial liabilities under the fair value option, and the presentation and disclosure requirements for financial instruments. The Company adopted ASU
2016
-
01
on
January 1, 2018.
Adoption of this ASU did
not
 impact the Company's consolidated financial position, results of operations or cash flows.
 
Classification of Cash Flow Elements
In
August 2016,
the FASB issued ASU
2016
-
15,
 
Statement of Cash Flows (Topic
230
): Classification of Certain Cash Receipts and Cash Payments,
 which affects the classification of certain cash receipts and cash payments on the statement of cash flows. ASU
2016
-
15
results in a change in cash flow classification of debt prepayment or extinguishment costs. ASU
2016
-
15
became effective
January 1, 2018
on a retrospective basis. Adoption of this ASU did
not
 impact the Company's consolidated financial position, results of operations or cash flows.
 
Income Taxes Related to Intra-entity Asset Transfers
In
October 2016,
FASB issued ASU
2016
-
16,
Intra-Entity Transfers of Assets Other Than Inventory
on simplifying the accounting for income taxes related to intra-entity asset transfers. The new guidance allows an entity to recognize the tax expense from the sale of an asset in the seller’s tax jurisdiction when the transfers occurs, even though the pre-tax effects of that transaction are eliminated in consolidation. ASU
2016
-
16
became effective
January 1, 2018,
which the Company adopted on a modified retrospective basis.
 
Restricted Cash in Statement of Cash Flows
In
November 2016,
the FASB issued ASU
2016
-
18,
 
Statement of Cash Flows (Topic
230
): Restricted Cash,
 which requires that a statement of cash flows explain the change during the period in the total of cash, cash equivalents, and amounts generally described as restricted cash or restricted cash equivalents. Therefore, amounts generally described as restricted cash and restricted cash equivalents should be included with cash and cash equivalents when reconciling the beginning-of-period and end-of-period total amounts shown on the statement of cash flows. The accounting standard update became effective
January 1, 2018
using a retrospective transition method for each period presented. Upon adoption, ASU
2016
-
18
resulted in a change in the presentation of restricted cash in the statement of cash flows for current and prior periods presented.
 
Derecognition of Nonfinancial Assets
In
February 2017,
the FASB issued ASU
2017
-
05,
 
Other Income—Gains and Losses from the Derecognition of Nonfinancial Assets (Subtopic
610
-
20
): Clarifying the Scope of Asset Derecognition Guidance and Accounting for Partial Sales of Nonfinancial Assets
, which requires entities to apply certain recognition and measurement principles in ASC
606
when they derecognize nonfinancial assets, and in substance, nonfinancial assets, and the counterparty is
not
a customer. The guidance applies to: (
1
) contracts to transfer to a noncustomer a nonfinancial asset or group of nonfinancial assets, or an ownership interest in a consolidated subsidiary that does
not
meet the definition of a business and is
not
a
not
-for-profit activity; and (
2
) contributions of nonfinancial assets that are
not
a business to a joint venture or other noncontrolled investee. The accounting standard update became effective
January 1, 2018
on a modified retrospective basis. Adoption of this ASU did
not
 impact the Company's consolidated financial position, results of operations or cash flows.
 
Income Taxes
In
March 2018,
FASB issued ASU
2018
-
05,
Amendments to SEC Paragraphs Pursuant to SEC Staff Accounting Bulletin
No.
118
to address the application of GAAP in situations when a registrant does
not
have the necessary information available, prepared or analyzed (including computations) in reasonable detail to complete the accounting for certain income tax effects of the Tax Act. As of
December 31, 2018,
the Company's analysis for the Transition Tax has been filed with its
December 31, 2017
tax return and the Company considered its accounting for this area of the Tax Act to be complete as of such date and did
not
make any measurement-period adjustments related to it. In addition, the Company considered its accounting for changes in the U.S. federal rate and deferred tax impact for the rate change to be complete. The Company also accounted for the tax impact related to other areas of the Tax Act and believe its analysis to be completed consistent with the guidance in ASU
2018
-
05.
The Company recognizes that the IRS is continuing to publish and finalize ongoing guidance with respect to the Act which
may
modify accounting interpretation for the Tax Act, the Company would look to account for these impacts in the period of such change is enacted.
 
Non-employee Stock-based Compensation
In
June 2018,
the FASB issued ASU
2018
-
07,
Improvements to Nonemployee Share-Based Payment Accounting,
which more closely aligns the accounting for employee and nonemployee stock-based compensation. Under the new standard, companies are
no
longer required to value non-employee awards differently from employee awards. The Company adopted this accounting standard update on
January 1, 2018
using a modified retrospective approach. Adoption of this ASU did
not
 impact the Company's consolidated financial position, results of operations or cash flows.
 
Recent Accounting Standards or Updates
Not
Yet Effective
 
Leases
In
February 2016,
the FASB issued ASU
2016
-
02,
 
Leases (Topic
842
),
 as subsequently updated, with fundamental changes as to how entities account for leases. Lessees will need to recognize a right-of-use asset and a lease liability for virtually all of their leases (other than leases that meet the definition of a short-term lease). The liability will be equal to the present value of lease payments. The asset will be based on the liability, subject to adjustment, such as for initial direct costs. Additional disclosures for leases will also be required.
 
The Company is adopting the new standard effective
January 1, 2019
using a modified retrospective method, and will
not
restate comparative periods. The modified retrospective transition approach requires lessees and lessors to recognize and measure existing leases at the date of initial application. The new standard provides a number of optional practical expedients in transition. The Company expects to elect the “package of practical expedients”, which permits it
not
to reassess under the new standard prior conclusions about lease identification, lease classification and initial direct costs.
 
The adoption of this standard on
January 1, 2019
is expected to have the effect of increasing assets and liabilities on the consolidated balance sheet by
$25.7
million, but is
not
expected to have a material impact on the consolidated statements of operations or cash flows. The most significant impact relates to (i) the recognition of new Right of Use (ROU) assets and lease liabilities on the balance sheet for operating leases; and (ii) providing significant new disclosures about leasing activities. Upon adoption, the Company will recognize operating lease liabilities of
$33.6
million, based on the present value of the remaining minimum rental payments under current leasing standards for existing operating leases. The Company will also recognize ROU assets of
$29.7
million, which represents the operating lease liability adjusted for accrued rent.
 
Financial Instruments with "Down Round" Features
In
July 2017,
the FASB issued ASU
2017
-
11,
 
Earnings Per Share (Topic
260
); Distinguishing Liabilities from Equity (Topic
480
); Derivatives and Hedging (Topic
815
): Accounting for Certain Financial Instruments with Down Round Features
. The amendments of this ASU update the classification analysis of certain equity-linked financial instruments, or embedded features, with down round features, as well as clarify existing disclosure requirements for equity-classified instruments. When determining whether certain financial instruments should be classified as liabilities or equity instruments, a down round feature
no
longer precludes equity classification when assessing whether the instrument is indexed to an entity’s own stock. The accounting standard update will be effective beginning in the
first
quarter of fiscal year
2019
using a modified retrospective approach. The Company completed its assessment of the new standard and determined the impact to the consolidated balance sheet would be material. The Company anticipates recording a
$41.0
million reduction to derivative liabilities and a corresponding
$41.0
million increase to equity on
January 1, 2019.
 
Fair Value Measurement
In
August 2018,
the FASB issued ASU
2018
-
13,
Fair Value Measurement (Topic
820
): Disclosure Framework—Changes to the Disclosure Requirements for Fair Value Measurement
, which amends ASC
820,
Fair Value Measurement
. ASU
2018
-
13
modifies the disclosure requirements for fair value measurements by removing, modifying or adding certain disclosures. The accounting standard update will be effective beginning in the
first
quarter of fiscal year
2020,
with removed and modified disclosures to be adopted on a retrospective basis, and new disclosures to be adopted on a prospective basis. The Company is in the initial stages of evaluating the impact of the new standard on its consolidated financial statements.
 
Collaborative Revenue Arrangements
In
November 2018,
the FASB issued ASU
2018
-
18,
Clarifying the Interaction between Topic
808
and Topic
606
, that clarifies the interaction between the guidance for certain collaborative arrangements and Topic
606,
the new revenue recognition standard. A collaborative arrangement is a contractual arrangement under which
two
or more parties actively participate in a joint operating activity and are exposed to significant risks and rewards that depend on the activity’s commercial success. The ASU provides guidance on how to assess whether certain transactions between collaborative arrangement participants should be accounted for within the revenue recognition standard. The accounting standard update will be effective beginning in the
first
quarter of fiscal year
2020
retroactively. The Company does
not
believe that the impact of the new standard on its consolidated financial statements will be material.
 
Credit Losses
In
June 2016,
the FASB issued ASU
2016
-
13,
Financial Instruments—Credit Losses (Topic
326
), Measurement of Credit Losses on Financial Instruments
. ASU
2016
-
13
requires entities to measure all expected credit losses for most financial assets held at the reporting date based on an expected loss model which includes historical experience, current conditions, and reasonable and supportable forecasts. Entities will now use forward-looking information to better form their credit loss estimates. ASU
2016
-
13
also requires enhanced disclosures to help financial statement users better understand significant estimates and judgments used in estimating credit losses, as well as the credit quality and underwriting standards of an entity's portfolio. ASU
2016
-
13
will become effective for the Company beginning in the
first
quarter of fiscal year
2020.
The Company does
not
believe that the impact of the new standard on its consolidated financial statements will be material.
XML 48 R33.htm IDEA: XBRL DOCUMENT v3.19.3
Note 8 - Net Loss Per Share Attributable to Common Stockholders (Tables)
12 Months Ended
Dec. 31, 2018
Notes Tables  
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Years Ended December 31,
(In thousands, except shares and per share amounts)
  2018   2017
           
(As Restated, Note 2)
Net loss attributable to Amyris, Inc.    
(230,235
)    
(155,982
)
Less deemed dividend related to beneficial conversion feature on Series A preferred stock    
     
(562
)
Less deemed dividend related to beneficial conversion feature on Series B preferred stock    
     
(634
)
Less deemed dividend related to beneficial conversion feature on Series D preferred stock    
     
(5,757
)
Less deemed dividend upon settlement of make-whole provision on Series A preferred stock    
     
(10,505
)
Less deemed dividend upon settlement of make-whole provision on Series B preferred stock    
     
(22,632
)
Less deemed dividend related to the recognition of discounts on Series A preferred stock upon conversion    
     
(21,578
)
Less deemed dividend related to the recognition of discounts on Series B preferred stock upon conversion    
     
(24,366
)
Less deemed dividend related to proceeds discount upon conversion of Series D preferred stock    
(6,852
)    
 
Add: losses allocated to participating securities    
13,991
     
40,159
 
Net loss attributable to Amyris, Inc. common stockholders   $
(223,096
)   $
(201,857
)
                 
Denominator:                
Weighted-average shares of common stock outstanding used in computing net loss per share of common stock, basic and diluted    
60,405,910
     
32,253,570
 
Basic and diluted loss per share   $
(3.69
)   $
(6.26
)
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Years Ended December 31,   2018   2017
        (As Restated, Note 2)
Period-end common stock warrants    
25,986,370
     
29,921,844
 
Convertible promissory notes (1)    
13,703,162
     
8,203,821
 
Period-end stock options to purchase common stock    
5,392,269
     
1,338,367
 
Period-end restricted stock units    
5,294,848
     
685,007
 
Period-end preferred shares on an as-converted basis    
2,955,732
     
4,504,212
 
Total potentially dilutive securities excluded from computation of diluted net loss per share    
53,332,381
     
44,653,251
 
XML 49 R37.htm IDEA: XBRL DOCUMENT v3.19.3
Note 12 - Stock-based Compensation (Tables)
12 Months Ended
Dec. 31, 2018
Notes Tables  
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Years Ended December 31,

(In thousands)
  2018   2017
Research and development   $
1,797
    $
2,204
 
Sales, general and administrative    
7,393
     
4,061
 
Total stock-based compensation expense   $
9,190
    $
6,265
 
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Years Ended December 31,   2018   2017
Expected dividend yield    
—%
     
—%
 
Risk-free interest rate    
2.8
%    
2.1
%
Expected term (in years)    
6.90
     
6.12
 
Expected volatility    
80
%    
84
%
Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block]
Year ended December 31,
  2018   2017
Options granted    
4,337,119
     
661,094
 
Weighted-average grant-date fair value per share   $
5.18
    $
3.26
 
Compensation expense related to stock options (in millions)   $
2.6
    $
3.3
 
Unrecognized compensation costs as of December 31 (in millions)   $
8.5
    $
2.7
 
Share-based Payment Arrangement, Option and Stock Appreciation Rights, Activity [Table Text Block]
    Number of
Stock
Options
  Weighted-
average
Exercise
Price
 
Weighted-average
Remaining
Contractual
Life

(in years)
 
Aggregate
Intrinsic
Value

(in thousands)
Outstanding - December 31, 2017    
1,338,367
    $
33.40
     
7.7
    $
97
 
Options granted    
4,337,119
    $
5.18
     
 
     
 
 
Options exercised    
(70,807
)   $
3.68
     
 
     
 
 
Options forfeited or expired    
(214,409
)   $
19.61
     
 
     
 
 
Outstanding - December 31, 2018    
5,390,270
    $
11.55
     
8.5
    $
29
 
Vested or expected to vest after December 31, 2018    
4,833,615
    $
12.28
     
8.4
    $
28
 
Exercisable at December 31, 2018    
972,229
    $
39.73
     
5.8
    $
12
 
Share-based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block]
    Number of
Restricted
Stock Units
  Weighted-
average
Grant-date
Fair Value
  Weighted-
average
Remaining
Contractual
Life
(in years)
Outstanding - December 31, 2017    
683,554
    $
8.66
     
1.4
 
Awarded    
5,452,664
    $
5.36
     
 
 
Vested    
(445,828
)   $
8.43
     
 
 
Forfeited    
(395,587
)   $
5.64
     
 
 
Outstanding - December 31, 2018    
5,294,803
    $
5.50
     
1.7
 
 Vested or expected to vest after December 31, 2018    
4,953,264
    $
5.50
     
1.6
 
Performance-based Stock Options [Member]  
Notes Tables  
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Stock Option Award with Performance and Market Vesting Conditions:    
Fair value of the Company’s common stock on grant date   $
5.08
 
Expected volatility    
70
%
Risk-free interest rate    
2.75
%
Dividend yield    
0.0
%
XML 50 R56.htm IDEA: XBRL DOCUMENT v3.19.3
Note 4 - Fair Value Measurement - Derivative Instruments (Details) - USD ($)
$ in Thousands
Dec. 31, 2018
Dec. 31, 2017
Derivative liabilities $ 42,796 $ 116,497
Derivative Liability, Equity-related [Member]    
Derivative liabilities 41,272 108,887
Derivative Liability, Debt-related [Member]    
Derivative liabilities $ 1,524 $ 7,610
XML 51 R52.htm IDEA: XBRL DOCUMENT v3.19.3
Note 3 - Balance Sheet Details - Other Noncurrent Liabilities (Details) - USD ($)
$ in Thousands
Dec. 31, 2018
Dec. 31, 2017
Liability for unrecognized tax benefit $ 6,582 $ 6,582
Deferred rent, net of current portion 6,440 7,818
Ginkgo partnership payments obligation, net of current portion 6,185 6,444
Contract liabilities, net of current portion 1,587 383
Contract termination fees, net of current portion(1) [1] 1,530
Capital leases, net of current portion 195 217
Other 673 2,214
Total other noncurrent liabilities $ 23,192 $ 23,658 [2]
[1] Contract liabilities, net of current portion at December 31, 2018 and 2017 includes $1,204 and $383 in connection with DSM, which is a related party.
[2] Accrual of the Ginkgo Partnership Payments obligation, net of reduction to deferred revenue liability.
XML 52 R81.htm IDEA: XBRL DOCUMENT v3.19.3
Note 11 - Related Party Transactions - Related Party Accounts Receivable (Details) - USD ($)
$ in Thousands
Dec. 31, 2018
Dec. 31, 2017
Accounts receivable, net $ 1,349 $ 14,668
DSM International B.V. [Member]    
Accounts receivable, net 1,071 12,823
Novvi LLC [Member]    
Accounts receivable, net 188 1,607
Total [Member]    
Accounts receivable, net $ 90 $ 238
XML 53 R71.htm IDEA: XBRL DOCUMENT v3.19.3
Note 10 - Revenue Recognition 1 (Details Textual) - USD ($)
1 Months Ended 6 Months Ended 12 Months Ended
Nov. 19, 2018
Aug. 03, 2017
Dec. 31, 2017
Nov. 30, 2017
Aug. 31, 2017
Jul. 31, 2017
Jun. 30, 2016
Apr. 30, 2016
Jun. 30, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Sep. 30, 2017
Sep. 30, 2015
Revenues, Total                   $ 63,604,000 $ 127,671,000      
Revenue from Contract with Customer, Including Assessed Tax                   63,604,000 127,671,000      
Long-term Debt, Gross     $ 195,819,000             228,921,000 195,819,000      
Due to Related Parties, Current, Total     20,019,000             23,667,000 20,019,000      
Debt Instrument, Unamortized Discount, Total                   17,100,000        
Interest Expense, Total                   42,703,000 37,081,000 [1]      
Increase (Decrease) in Contract with Customer, Liability                   3,158,000 (7,241,000)      
Contract with Customer, Liability, Current [3],[4]     4,308,000 [2]             8,236,000 4,308,000 [2]      
Revenue, Remaining Performance Obligation, Constrained Variable Consideration, Amount                   21,400,000        
Accounting Standards Update 2014-09 [Member]                            
Increase (Decrease) in Contract with Customer, Liability                   3,900,000        
Contract with Customer, Liability, Current                   800,000        
Loans Payable [Member]                            
Long-term Debt, Gross     47,410,000             52,910,000 47,410,000      
Ginkgo Collaboration Note [Member] | Loans Payable [Member]                            
Long-term Debt, Gross     12,000,000 $ 12,000,000           12,000,000 12,000,000      
Debt Instrument, Unamortized Discount, Total                   6,600,000        
Licenses and Royalties [Member]                            
Revenues, Total                   7,658,000 48,703,000      
Revenue from Contract with Customer, Including Assessed Tax                   7,658,000 48,703,000 [5]      
Royalty [Member]                            
Contract with Customer, Liability, Revenue Recognized                   3,300,000        
Technology Investment Agreement with DARPA [Member]                            
Maximum DARPA Funding to be Received if all Milestones are Achieved                           $ 35,000,000
Collective Obligation Due                           $ 15,500,000
Firmenich [Member] | Master Collaboration Agreement [Member] | Flavors and Fragrances Compounds [Member]                            
Sales Margin Company Percentage Split           30.00%                
Sales Margin Collaborator Percentage Split           70.00%                
Return Required for Collaboration Partner Before Adjusting Split on Sales Margin           $ 15,000,000                
Sales Margin Company Percentage Split Following Return Requirements           50.00%                
Success Bonus           $ 2,500,000                
Contingent Consideration Liability                   500,000        
Nenter & Co., Inc. [Member] | Supply Agreements [Member]                            
Supply Agreement, Renewable Terms               5 years            
DSM International B.V. [Member]                            
Consideration Transferred   $ 34,000,000     $ 34,000,000                  
Warrants and Rights Outstanding         10,600,000                  
Performance Agreement, Contingent Obligation     1,800,000               1,800,000      
DSM International B.V. [Member] | Cash Warrants [Member]                            
Warrants and Rights Outstanding         10,600,000                  
Revenues, Total         $ 7,800,000                  
DSM International B.V. [Member] | License [Member]                            
Revenue from Contract with Customer, Including Assessed Tax     $ 27,500,000               54,600,000      
DSM International B.V. [Member] | Collaborative Arrangement [Member]                            
Receivable from Collaborators                         $ 9,000,000  
Credit to Collaboration Agreements                         12,000,000  
DSM International B.V. [Member] | Collaborative Arrangement [Member] | Maximum [Member]                            
Credit to Collaboration Agreements                         6,000,000  
DSM International B.V. [Member] | DSM Licneses [Member]                            
Contract with Customer, Liability, Revenue Recognized                     3,300,000      
Contract with Customer, Liability, Total                         $ 4,500,000  
DSM International B.V. [Member] | DSM Value Sharing Agreement [Member]                            
Agreement, Accelerated Payment Fee                   750,000        
Revenue from Contract with Customer, Including Assessed Tax                   7,900,000        
DSM International B.V. [Member] | DSM November 2018 Supply Agreement Amendment [Member]                            
Cash Reservation Fee, Payable $ 15,500,000                          
Stock Issued During Period, Shares, New Issues 1,643,991                          
Cash Fee $ 7,300,000                          
Contingent Fee, Share Price Trigger $ 4.41                          
DSM International B.V. [Member] | DSM November 2018 Letter Agreement [Member]                            
Common Stock, Value Reserved for Future Issuance $ 5,000,000                          
Ginkgo Bioworks [Member]                            
Expected Proceeds from Collaborators             $ 20,000,000              
Royalty Percentage             10.00%              
Proceeds from Collaborators                 $ 5,000,000     $ 15,000,000    
Ginkgo Bioworks, Inc. [Member] | Partnership Agreement [Member]                            
Sales Margin Company Percentage Split       50.00%                    
Partnership Payments, Quarterly Fees       $ 800,000                    
Partnership Payments Expected to Be Made       12,700,000                    
Payments for Other Fees       $ 500,000                    
Collaboration Agreement Period       2 years                    
Collaboration Agreement, Automatic Renewal Term       1 year                    
Increase (Decrease) in Notes Payable, Current, Total                     13,100,000      
Ginkgo Bioworks, Inc. [Member] | Partnership Agreement [Member] | Other Liabilities [Member]                            
Due to Related Parties, Current, Total                   $ 6,100,000        
Ginkgo Bioworks, Inc. [Member] | Partnership Agreement [Member] | License [Member]                            
Related Party Costs                     6,100,000      
Interest Expense, Total                     7,000,000      
Ginkgo Bioworks, Inc. [Member] | Partnership Agreement [Member] | Licenses and Royalties [Member]                            
Increase (Decrease) in Revenue                     $ 13,100,000      
[1] Correction to amortization of debt discounts, and interest expense in connection with partnership payments obligation.
[2] Revision to accounting for equity received in satisfaction of a customer receivable.
[3] The balance in contract liabilities at December 31, 2017 represents deferred revenue, current prior to the Company's adoption of ASC 606, "Revenue".
[4] The balance in contract liabilities, current at December 31, 2017 represents deferred revenue, current prior to the Company's adoption of ASC 606, "Revenue".
[5] Ginkgo partnership obligation and promissory note issuance recorded as reduction to revenue and correction of errors in recording revenue from non-cash consideration.
XML 54 R75.htm IDEA: XBRL DOCUMENT v3.19.3
Note 10 - Revenue Recognition - Contract Balances (Details) - USD ($)
$ in Thousands
Dec. 31, 2018
Dec. 31, 2017
Accounts receivable, net $ 16,003 $ 18,953 [1]
Accounts receivable - related party, net 1,349 4,767 [1]
Accounts receivable, unbilled - related party 8,021 9,901
Accounts receivable, unbilled, noncurrent - related party 1,203 7,940
Contract liabilities(1) [2],[3] 8,236 4,308 [4]
Contract liabilities, noncurrent(2) [5] $ 1,587
[1] Reclassification of related party accounts receivable to a separate line on the balance sheet.
[2] The balance in contract liabilities at December 31, 2017 represents deferred revenue, current prior to the Company's adoption of ASC 606, "Revenue".
[3] The balance in contract liabilities, current at December 31, 2017 represents deferred revenue, current prior to the Company's adoption of ASC 606, "Revenue".
[4] Revision to accounting for equity received in satisfaction of a customer receivable.
[5] The balances in contract liabilities, noncurrent are included in other noncurrent liabilities on the consolidated balance sheets.
XML 55 R85.htm IDEA: XBRL DOCUMENT v3.19.3
Note 12 - Stock-based Compensation - Share-based Payment Award, Stock Options with Performance, Valuation Assumptions (Details) - Performance-based Stock Options [Member]
12 Months Ended
Dec. 31, 2018
$ / shares
Fair value of the Company’s common stock on grant date (in dollars per share) $ 5.08
Expected volatility 70.00%
Risk-free interest rate 2.75%
Dividend yield 0.00%
XML 56 R89.htm IDEA: XBRL DOCUMENT v3.19.3
Note 12 - Stock-based Compensation - Temporal Display of Share-based Compensation, Restricted Stock and Restricted Stock Units Activity (Details) - Restricted Stock Units (RSUs) [Member] - $ / shares
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Outstanding, RSUs (in shares) 683,554  
Outstanding, weighted average grant-date fair value (in dollars per share) $ 8.66  
Outstanding, weighted average remaining contractual life (Year) 1 year 255 days 1 year 146 days
Awarded (in shares) 5,452,664  
Awarded, weighted average grant-date fair value (in dollars per share) $ 5.36 $ 5.51
Vested (in shares) (445,828)  
Vested, weighted average grant-date fair value (in dollars per share) $ 8.43  
Forfeited (in shares) (395,587)  
Forfeited, weighted average grant-date fair value (in dollars per share) $ 5.64  
Outstanding, RSUs (in shares) 5,294,803 683,554
Outstanding, weighted average grant-date fair value (in dollars per share) $ 5.50 $ 8.66
Vested or expected to vest (in shares) 4,953,264  
Vested or expected to vest, weighted average grant-date fair value (in dollars per share) $ 5.50  
Vested or expected to vest, weighted average remaining contractual life (Year) 1 year 219 days  
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    Note 11 - Related Party Transactions - Related Party Debt (Details) - USD ($)
    Dec. 31, 2018
    Dec. 31, 2017
    Jul. 31, 2015
    Related party debt, gross $ 228,921,000 $ 195,819,000  
    Unamortized Debt Premium (17,142,000) (32,115,000)  
    Due to related parties, net 209,697,000 163,704,000  
    Total [Member] | Related Party 2014 144A Convertible Notes [Member]      
    Related party debt, gross     $ 9,700,000
    Temasek [Member] | Related Party 2014 144A Convertible Notes [Member]      
    Related party debt, gross     $ 10,000,000
    Related Party Debt [Member] | DSM Note [Member]      
    Due to related parties, net   16,961,000  
    Related Party Debt [Member] | Total [Member]      
    Related party debt, gross 9,705,000 35,116,000  
    Unamortized Debt Premium (422,000) (659,000)  
    Due to related parties, net 9,283,000 34,457,000  
    Related Party Debt [Member] | Total [Member] | The 2014 144A Notes [Member]      
    Related party debt, gross 9,705,000 9,705,000  
    Unamortized Debt Premium (422,000) (1,538,000)  
    Due to related parties, net 9,283,000 8,167,000  
    Related Party Debt [Member] | Total [Member] | August 2013 Convertible Notes [Member]      
    Related party debt, gross 21,711,000  
    Unamortized Debt Premium 897,000  
    Due to related parties, net 22,608,000  
    Related Party Debt [Member] | Total [Member] | R&D Note [Member]      
    Related party debt, gross 3,700,000  
    Unamortized Debt Premium (18,000)  
    Due to related parties, net 3,682,000  
    Related Party Debt [Member] | DSM International B.V. [Member]      
    Related party debt, gross 25,000,000 25,393,000  
    Unamortized Debt Premium (6,311,000) (8,039,000)  
    Due to related parties, net 18,689,000 17,354,000  
    Related Party Debt [Member] | DSM International B.V. [Member] | DSM Note [Member]      
    Related party debt, gross 25,000,000 25,000,000  
    Unamortized Debt Premium (6,311,000) (8,039,000)  
    Due to related parties, net 18,689,000    
    Related Party Debt [Member] | DSM International B.V. [Member] | Other Loans Payable [Member]      
    Related party debt, gross 393,000  
    Unamortized Debt Premium  
    Due to related parties, net 393,000  
    Related Party Debt [Member] | Biolding Investment SA [Member] | Private Placement February 2016 [Member]      
    Related party debt, gross 2,000,000  
    Unamortized Debt Premium  
    Due to related parties, net 2,000,000  
    Related Party Debt [Member] | Foris Ventures, LLC [Member]      
    Related party debt, gross 49,705,000 77,509,000  
    Unamortized Debt Premium (7,349,000) (10,949,000)  
    Due to related parties, net 42,356,000 66,560,000  
    Related Party Debt [Member] | Foris Ventures, LLC [Member] | Related Party 2014 144A Convertible Notes [Member]      
    Related party debt, gross 5,000,000 5,000,000  
    Unamortized Debt Premium (181,000) (660,000)  
    Due to related parties, net 4,819,000 4,340,000  
    Related Party Debt [Member] | Temasek [Member] | Related Party 2014 144A Convertible Notes [Member]      
    Related party debt, gross 10,000,000 10,000,000  
    Unamortized Debt Premium (435,000) (1,591,000)  
    Due to related parties, net $ 9,565,000 $ 8,409,000  

    XML 59 R7.htm IDEA: XBRL DOCUMENT v3.19.3
    Consolidated Statements of Stockholders' Deficit and Mezzanine Equity - USD ($)
    $ in Thousands
    Series A Preferred Stock [Member]
    Preferred Stock [Member]
    Series A Preferred Stock [Member]
    Common Stock [Member]
    Series A Preferred Stock [Member]
    Additional Paid-in Capital [Member]
    Series A Preferred Stock [Member]
    AOCI Attributable to Parent [Member]
    Series A Preferred Stock [Member]
    Retained Earnings [Member]
    Series A Preferred Stock [Member]
    Noncontrolling Interest [Member]
    Series A Preferred Stock [Member]
    Mezzanine Equity, Common Stock [Member]
    Series A Preferred Stock [Member]
    Series B Preferred Stock [Member]
    Preferred Stock [Member]
    Series B Preferred Stock [Member]
    Common Stock [Member]
    Series B Preferred Stock [Member]
    Additional Paid-in Capital [Member]
    Series B Preferred Stock [Member]
    AOCI Attributable to Parent [Member]
    Series B Preferred Stock [Member]
    Retained Earnings [Member]
    Series B Preferred Stock [Member]
    Noncontrolling Interest [Member]
    Series B Preferred Stock [Member]
    Mezzanine Equity, Common Stock [Member]
    Series B Preferred Stock [Member]
    Series D Preferred Stock [Member]
    Preferred Stock [Member]
    Series D Preferred Stock [Member]
    Common Stock [Member]
    Series D Preferred Stock [Member]
    Additional Paid-in Capital [Member]
    Series D Preferred Stock [Member]
    AOCI Attributable to Parent [Member]
    Series D Preferred Stock [Member]
    Retained Earnings [Member]
    Series D Preferred Stock [Member]
    Noncontrolling Interest [Member]
    Series D Preferred Stock [Member]
    Mezzanine Equity, Common Stock [Member]
    Series D Preferred Stock [Member]
    Preferred Stock [Member]
    Common Stock [Member]
    Additional Paid-in Capital [Member]
    AOCI Attributable to Parent [Member]
    Retained Earnings [Member]
    Noncontrolling Interest [Member]
    Mezzanine Equity, Common Stock [Member]
    Total
    Balance (in shares) at Dec. 31, 2016                                                 18,273,921            
    Balance at Dec. 31, 2016                                                 $ 2 $ 990,895 $ (40,904) $ (1,134,438) $ 937 $ 5,000 $ (183,508)
    Issuance of Series A preferred stock for cash (in shares) 22,140             55,700             12,958                            
    Issuance of Series A preferred stock for cash $ 562 $ 562 $ 16,675 $ 16,675 $ 6,197 $ 6,197                
    Issuance of Series B preferred stock upon conversion of debt, net of issuance costs of $0 (in shares)                 40,204                                            
    Issuance of Series B preferred stock upon conversion of debt, net of issuance costs of $0                 11,530 11,530                                
    Issuance of common stock due to rounding from reverse stock split (in shares)                                                 6,473            
    Issuance of common stock due to rounding from reverse stock split                                                
    Issuance of common stock for cash (in shares)                                                 2,826,711            
    Issuance of common stock for cash                                                 5,527 5,527
    Issuance of common stock upon conversion of preferred stock (in shares)                                                 (108,831) 17,274,017            
    Issuance of common stock upon conversion of preferred stock                                                 $ 3 3
    Issuance of common stock upon conversion of debt (in shares)                                                 2,257,786            
    Issuance of common stock upon conversion of debt                                                 12,687 12,687
    Issuance of common stock for settlement of debt principal payments (in shares)                                                 1,246,165            
    Issuance of common stock for settlement of debt principal payments                                                 10,707 10,707
    Issuance of common stock for settlement of debt interest payments (in shares)                                                 400,967            
    Issuance of common stock for settlement of debt interest payments                                                 3,436 3,436
    Issuance of common stock upon exercise of warrants (in shares)                                                 3,148,097            
    Issuance of common stock upon exercise of warrants                                                 50,449 50,449
    Issuance of common stock upon restricted stock settlement (in shares)                                                 156,104            
    Issuance of common stock upon restricted stock settlement                                                 (385) (385)
    Issuance of common stock upon ESPP purchase (in shares)                                                 47,058            
    Issuance of common stock upon ESPP purchase                                                
    Issuance of common stock upon exercise of stock options (in shares)                                                 134            
    Issuance of common stock upon exercise of stock options                                                 1 1
    Beneficial conversion feature of preferred stock 562 562 634 634 5,757 5,757                
    Deemed dividend (562) (562) (634) (634) (5,757) (5,757)                
    Deemed dividend on preferred stock discounts upon conversion of preferred stock 21,578 21,578 24,366 24,366                              
    Deemed dividend on preferred stock discounts upon conversion of preferred stock (21,578) (21,578) (24,366) (24,366)                                
    Settlement of make-whole provision on preferred stock 10,505 10,505 22,632 22,632                                
    Deemed dividend upon settlement of make-whole provision on preferred stock $ (10,505) (10,505) $ (22,632) (22,632)                                
    Stock-based compensation                                                 6,265 6,265
    Foreign currency translation adjustment                                                 (1,252) (1,252)
    Net loss                                                 (155,982) (155,982)
    Balance (in shares) at Dec. 31, 2017                                                 22,171 45,637,433            
    Balance at Dec. 31, 2017                                                 $ 5 1,114,546 (42,156) (1,290,420) 937 5,000 (217,088)
    Issuance of Series A preferred stock for cash                                                 1,415 1,415
    Issuance of common stock for cash (in shares)                                                 205,168            
    Issuance of common stock upon conversion of preferred stock (in shares)                                                 (7,515) 1,548,480            
    Issuance of common stock upon conversion of preferred stock                                                
    Issuance of common stock upon conversion of debt (in shares)                                                 5,674,926            
    Issuance of common stock upon conversion of debt                                                 $ 1 42,368 42,369
    Issuance of common stock for settlement of debt interest payments (in shares)                                                 238,898            
    Issuance of common stock for settlement of debt interest payments                                                 1,800 $ 1,800
    Issuance of common stock upon exercise of warrants (in shares)                                                 20,891,038           20,928,439
    Issuance of common stock upon exercise of warrants                                                 $ 2 62,152 $ 62,154
    Issuance of common stock upon restricted stock settlement (in shares)                                                 407,858            
    Issuance of common stock upon restricted stock settlement                                                 (260) (260)
    Issuance of common stock upon ESPP purchase (in shares)                                                 246,230            
    Issuance of common stock upon ESPP purchase                                                 777 $ 777
    Issuance of common stock upon exercise of stock options (in shares)                                                 70,807           70,807
    Issuance of common stock upon exercise of stock options                                                 288 $ 288
    Deemed dividend on preferred stock discounts upon conversion of preferred stock                             6,852 6,852                
    Deemed dividend on preferred stock discounts upon conversion of preferred stock                                 $ (6,852) $ (6,852)                
    Deemed dividend upon settlement of make-whole provision on preferred stock                                                            
    Stock-based compensation                                                 9,190 9,190
    Foreign currency translation adjustment                                                 (1,187) (1,187)
    Net loss                                                 (230,235) (230,235)
    Cumulative effect of change in accounting principle (Accounting Standards Update 2014-09 [Member]) at Dec. 31, 2017                                                 (762) (762)
    Settlement of derivatives liability upon exercise of warrants                                                 108,670 108,670
    Issuance of common stock in private placement - related party, net of issuance costs of $0 (in shares)                                                 1,643,991            
    Issuance of common stock in private placement - related party, net of issuance costs of $0                                                 6,050 $ 6,050
    Balance (in shares) at Dec. 31, 2018                                                 14,656 76,564,829           76,564,829
    Balance at Dec. 31, 2018                                                 $ 8 $ 1,346,996 $ (43,343) $ (1,521,417) $ 937 $ 5,000 $ (216,819)
    XML 60 R43.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 2 - Restatement of Consolidated Financial Statements - Consolidated Financial Statements (Details) - USD ($)
    $ / shares in Units, $ in Thousands
    1 Months Ended 12 Months Ended
    Dec. 28, 2017
    May 31, 2017
    Dec. 31, 2018
    Dec. 31, 2017
    Dec. 31, 2018
    Dec. 31, 2017
    Dec. 31, 2016
    Cash and cash equivalents     $ 45,353 $ 57,059 $ 45,353 $ 57,059  
    Restricted cash     741 2,994 741 2,994  
    Accounts receivable, net         16,003 18,953 [1]  
    Accounts receivable - related party, net         1,349 4,767 [1]  
    Accounts receivable, unbilled - related party         8,021 9,901  
    Inventories         9,693 5,408  
    Prepaid expenses and other current assets         10,566 4,919 [2]  
    Total current assets         92,215 104,001  
    Property, plant and equipment, net         19,756 13,892  
    Accounts receivable, unbilled, noncurrent – related party         1,203 7,940  
    Restricted cash, noncurrent     960 959 960 959  
    Recoverable taxes from Brazilian government entities         3,005 1,445  
    Other assets         7,958 12,559 [3]  
    Total assets         127,925 140,796  
    Accounts payable         26,844 15,515 [4]  
    Accrued and other current liabilities         28,979 29,202 [5]  
    Contract liabilities [6],[7]         8,236 4,308 [8]  
    Debt, current portion         124,010 36,924  
    Related party debt, current portion         23,667 20,019  
    Total current liabilities         211,736 105,968  
    Long-term debt, net of current portion         43,331 60,220 [9]  
    Related party debt, net of current portion         18,689 46,541  
    Derivative liabilities         42,796 116,497 [10]  
    Other noncurrent liabilities         23,192 23,658 [11]  
    Total liabilities         339,744 352,884  
    Mezzanine Equity         5,000 5,000  
    Preferred stock          
    Common stock - $0.0001 par value         8 5  
    Additional paid-in capital         1,346,996 1,114,546 [12]  
    Accumulated other comprehensive loss         (43,343) (42,156)  
    Accumulated deficit         (1,521,417) (1,290,420) [13]  
    Total Amyris, Inc. stockholders’ deficit         (217,756) (218,025)  
    Noncontrolling interest         937 937  
    Total stockholders' deficit         (216,819) (217,088) $ (183,508)
    Total liabilities, mezzanine equity and stockholders' deficit         $ 127,925 140,796  
    Revenue from Contract with Customer, Including Assessed Tax     63,604 127,671      
    Cost of products sold     36,698 62,307 [14]      
    Research and development     68,722 57,562 [15]      
    Sales, general and administrative     90,902 63,853 [16]      
    Total cost and operating expenses     200,187 183,722 [16]      
    Loss from operations     (136,583) (56,051)      
    Disposal Group, Not Discontinued Operation, Gain (Loss) on Disposal $ 5,700   (1,778) 5,732      
    Interest expense     (42,703) (37,081) [17]      
    Gain (Loss) on Derivative Instruments, Net, Pretax, Total     (30,880) (48,852) [18]      
    Gain (Loss) on Extinguishment of Debt, Total   $ (1,900) (17,424) (11,897) [19]      
    Other income (expense), net     (2,949) (956)      
    Total other expense, net     (93,652) (93,054)      
    Loss before income taxes     (230,235) (149,105)      
    Provision for income taxes     (6,877) [20]      
    Net loss     (230,235) (155,982)      
    Less deemed dividend on capital distribution to related parties [19]            
    Less deemed dividend related to beneficial conversion feature on Series A preferred stock     (562)      
    Less deemed dividend related to beneficial conversion feature on Series B preferred stock     (634)      
    Less deemed dividend related to beneficial conversion feature on Series D preferred stock     (5,757)      
    Less deemed dividend upon settlement of make-whole provision on Series A preferred stock     (10,505) [21]      
    Label Less deemed dividend upon settlement of make-whole provision on Series B preferred stock     (22,632) [21]      
    Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series A preferred stock     (21,578) [21]      
    Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series B preferred stock     (24,366) [21]      
    Add: losses allocated to participating securities     13,991 40,159 [22]      
    Net loss attributable to Amyris, Inc. common stockholders     $ (223,096) $ (201,857)      
    Basic and diluted loss per share (in dollars per share)     $ (3.69) $ (6.26)      
    Weighted-average shares of common stock outstanding used in computing net loss per share of common stock, basic and diluted (in shares)     60,405,910 32,253,570      
    Depreciation and amortization     $ 4,921 $ 11,358      
    (Gain) loss on disposal of property, plant and equipment     941 142      
    Stock-based compensation     9,190 6,265      
    Amortization of debt discount     16,602 15,239      
    (Gain) loss upon extinguishment of debt     17,424 11,897      
    Receipt of equity in connection with collaboration arrangements revenue            
    (Gain) loss from change in fair value of derivative liabilities     30,880 48,852      
    (Gain) loss on foreign currency exchange rates     (2,223) (1,230)      
    Noncash revenue reduction related to issuance of debt obligations under Ginkgo Partnership Agreement     13,413      
    Non-cash gain on divestiture $ (5,700)   1,778 (5,732)      
    Receipt of noncash consideration in connection with license revenue     (8,046)      
    Accounts receivable     7,448 (19,647)      
    Accounts receivable, unbilled – related party     8,056 (7,940)      
    Inventories     (4,416) (3,126)      
    Prepaid expenses and other assets     (6,383) (18,730)      
    Accounts payable     11,603 5,452      
    Accrued and other liabilities     8,461 13,877      
    Increase (Decrease) in Contract with Customer, Liability     3,158 (7,241)      
    Net cash used in operating activities     (109,366) (101,179)      
    Proceeds from Divestiture of Businesses     54,827      
    Change in short-term investments       1,293      
    Change in restricted cash            
    Purchases of property, plant and equipment     (12,472) (4,412)      
    Net cash (used in) provided by investing activities     (12,472) 51,708      
    Proceeds from issuance of convertible preferred stock     98,246      
    Proceeds from exercises of common stock options     288      
    Payment of minimum employee taxes withheld upon net share settlement of restricted stock units     (260) (385)      
    Proceeds from issuance of common stock in August 2017 offering     5,759      
    Issuance costs incurred     (2,159)      
    Change in restricted cash related to contingently redeemable common stock            
    Proceeds from issuance of debt, net of issuance costs     94,371 18,925      
    Principal payments on debt     (41,668) (37,500)      
    Payment of swap termination     (3,113)      
    Payment on early redemption of debt     (1,909)      
    Net cash provided by financing activities     107,957 77,864      
    Effect of exchange rate changes on cash, cash equivalents and restricted cash     (77) 186      
    Net (decrease) increase in cash, cash equivalents and restricted cash     (13,958) 28,579      
    Cash, cash equivalents and restricted cash at beginning of year     61,012 32,433      
    Cash, cash equivalents and restricted cash at end of year     47,054 61,012      
    Cash and cash equivalents     45,353 57,059      
    Restricted cash, current     741 2,994      
    Restricted cash, noncurrent     960 959      
    Cash paid for interest     18,524 11,539      
    Issuance of common stock upon conversion of convertible notes     24,970 28,702      
    Accrued interest added to debt principal     3,664 2,816      
    Issuance of common stock for settlement of debt principal and interest payments     1,800 3,436      
    Financing of insurance premium under note payable     495 467      
    Issuance of convertible preferred stock upon conversion of debt     40,204      
    Settlement of debt principal by a related party     25,000      
    Issuance of note payable in exchange for debt extinguishment with third party     16,954      
    Issuance of common stock for settlement of debt     10,708      
    Issuance of preferred stock attributed to derivative liabilities     72,725      
    Preferred Stock Series A and Series B [Member]              
    Less cumulative dividends on Series A and Series B preferred stock [23]            
    Renewable Products [Member]              
    Revenue from Contract with Customer, Including Assessed Tax     33,598 42,370      
    Licenses and Royalties [Member]              
    Revenue from Contract with Customer, Including Assessed Tax     7,658 48,703 [24]      
    Grants and Collaborations [Member]              
    Revenue from Contract with Customer, Including Assessed Tax     22,348 36,598      
    Previously Reported [Member]              
    Cash and cash equivalents       57,059   57,059  
    Restricted cash       2,994   2,994  
    Accounts receivable, net [1]           24,281  
    Accounts receivable - related party, net [1]           9,340  
    Accounts receivable, unbilled - related party            
    Inventories           5,408  
    Prepaid expenses and other current assets [2]           5,525  
    Total current assets           104,607  
    Property, plant and equipment, net           13,892  
    Accounts receivable, unbilled, noncurrent – related party           7,940  
    Restricted cash, noncurrent       959   959  
    Recoverable taxes from Brazilian government entities           1,445  
    Other assets [3]           22,640  
    Total assets           151,483  
    Accounts payable [4]           15,921  
    Accrued and other current liabilities [5]           29,402  
    Contract liabilities [8]           4,880  
    Debt, current portion           36,924  
    Related party debt, current portion           20,019  
    Total current liabilities           107,146  
    Long-term debt, net of current portion [9]           61,893  
    Related party debt, net of current portion           46,541  
    Derivative liabilities [10]           119,978  
    Other noncurrent liabilities [11]           10,632  
    Total liabilities           346,190  
    Mezzanine Equity           5,000  
    Preferred stock            
    Common stock - $0.0001 par value           5  
    Additional paid-in capital [12]           1,048,274  
    Accumulated other comprehensive loss           (42,156)  
    Accumulated deficit [13]           (1,206,767)  
    Total Amyris, Inc. stockholders’ deficit           (200,644)  
    Noncontrolling interest           937  
    Total stockholders' deficit           (199,707)  
    Total liabilities, mezzanine equity and stockholders' deficit           151,483  
    Revenue from Contract with Customer, Including Assessed Tax       143,444      
    Cost of products sold [14]       62,713      
    Research and development [15]       57,027      
    Sales, general and administrative [16]       63,219      
    Total cost and operating expenses [16]       182,959      
    Loss from operations       (39,515)      
    Disposal Group, Not Discontinued Operation, Gain (Loss) on Disposal       5,732      
    Interest expense [17]       (34,033)      
    Gain (Loss) on Derivative Instruments, Net, Pretax, Total [18]       (1,742)      
    Gain (Loss) on Extinguishment of Debt, Total [19]       (1,521)      
    Other income (expense), net       (955)      
    Total other expense, net       (32,519)      
    Loss before income taxes       (72,034)      
    Provision for income taxes [20]       (295)      
    Net loss       (72,329)      
    Less deemed dividend on capital distribution to related parties [19]       (8,648)      
    Less deemed dividend related to beneficial conversion feature on Series A preferred stock       (562)      
    Less deemed dividend related to beneficial conversion feature on Series B preferred stock       (634)      
    Less deemed dividend related to beneficial conversion feature on Series D preferred stock       (5,757)      
    Less deemed dividend upon settlement of make-whole provision on Series A preferred stock [21]            
    Label Less deemed dividend upon settlement of make-whole provision on Series B preferred stock [21]            
    Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series A preferred stock [21]            
    Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series B preferred stock [21]            
    Add: losses allocated to participating securities [22]            
    Net loss attributable to Amyris, Inc. common stockholders       $ (93,369)      
    Basic and diluted loss per share (in dollars per share)       $ (2.89)      
    Weighted-average shares of common stock outstanding used in computing net loss per share of common stock, basic and diluted (in shares)       32,253,570      
    Depreciation and amortization       $ 11,358      
    (Gain) loss on disposal of property, plant and equipment       142      
    Stock-based compensation       6,265      
    Amortization of debt discount       12,490      
    (Gain) loss upon extinguishment of debt       1,521      
    Receipt of equity in connection with collaboration arrangements revenue       (2,661)      
    (Gain) loss from change in fair value of derivative liabilities       1,742      
    (Gain) loss on foreign currency exchange rates       (1,230)      
    Noncash revenue reduction related to issuance of debt obligations under Ginkgo Partnership Agreement            
    Non-cash gain on divestiture       (5,732)      
    Receipt of noncash consideration in connection with license revenue       (8,046)      
    Accounts receivable       (19,647)      
    Accounts receivable, unbilled – related party       (7,940)      
    Inventories       (3,126)      
    Prepaid expenses and other assets       (19,336)      
    Accounts payable       5,858      
    Accrued and other liabilities       7,295      
    Increase (Decrease) in Contract with Customer, Liability       (7,241)      
    Net cash used in operating activities       (100,617)      
    Proceeds from Divestiture of Businesses       54,827      
    Change in short-term investments       712      
    Change in restricted cash       865      
    Purchases of property, plant and equipment       (4,412)      
    Net cash (used in) provided by investing activities       51,992      
    Proceeds from issuance of convertible preferred stock       101,124      
    Proceeds from exercises of common stock options       160      
    Payment of minimum employee taxes withheld upon net share settlement of restricted stock units       (385)      
    Proceeds from issuance of common stock in August 2017 offering            
    Issuance costs incurred            
    Change in restricted cash related to contingently redeemable common stock       1,046      
    Proceeds from issuance of debt, net of issuance costs       18,925      
    Principal payments on debt       (37,500)      
    Payment of swap termination       (3,113)      
    Payment on early redemption of debt       (1,909)      
    Net cash provided by financing activities       78,348      
    Effect of exchange rate changes on cash, cash equivalents and restricted cash       186      
    Net (decrease) increase in cash, cash equivalents and restricted cash       29,909      
    Cash, cash equivalents and restricted cash at beginning of year     57,059 27,150      
    Cash, cash equivalents and restricted cash at end of year       57,059      
    Cash and cash equivalents       57,059      
    Restricted cash, current       2,994      
    Restricted cash, noncurrent       959      
    Cash paid for interest       11,539      
    Issuance of common stock upon conversion of convertible notes       28,702      
    Accrued interest added to debt principal       2,816      
    Issuance of common stock for settlement of debt principal and interest payments       3,436      
    Financing of insurance premium under note payable       467      
    Issuance of convertible preferred stock upon conversion of debt       40,204      
    Settlement of debt principal by a related party       25,000      
    Issuance of note payable in exchange for debt extinguishment with third party       16,954      
    Issuance of common stock for settlement of debt       10,708      
    Issuance of preferred stock attributed to derivative liabilities            
    Previously Reported [Member] | Preferred Stock Series A and Series B [Member]              
    Less cumulative dividends on Series A and Series B preferred stock [23]       (5,439)      
    Previously Reported [Member] | Renewable Products [Member]              
    Revenue from Contract with Customer, Including Assessed Tax       45,781      
    Previously Reported [Member] | Licenses and Royalties [Member]              
    Revenue from Contract with Customer, Including Assessed Tax [24]       57,703      
    Previously Reported [Member] | Grants and Collaborations [Member]              
    Revenue from Contract with Customer, Including Assessed Tax       39,960      
    Restatement Adjustment [Member]              
    Cash and cash equivalents [25]          
    Restricted cash [25]          
    Accounts receivable, net [1]           (5,328)  
    Accounts receivable - related party, net [1]           (4,573)  
    Accounts receivable, unbilled - related party           9,901  
    Inventories            
    Prepaid expenses and other current assets [2]           (606)  
    Total current assets           (606)  
    Property, plant and equipment, net            
    Accounts receivable, unbilled, noncurrent – related party            
    Restricted cash, noncurrent [25]          
    Recoverable taxes from Brazilian government entities            
    Other assets [3]           (10,081)  
    Total assets           (10,687)  
    Accounts payable [4]           (406)  
    Accrued and other current liabilities [5]           (200)  
    Contract liabilities [8]           (572)  
    Debt, current portion            
    Related party debt, current portion            
    Total current liabilities           (1,178)  
    Long-term debt, net of current portion [9]           (1,673)  
    Related party debt, net of current portion            
    Derivative liabilities [10]           (3,481)  
    Other noncurrent liabilities [11]           13,026  
    Total liabilities           6,694  
    Mezzanine Equity            
    Preferred stock            
    Common stock - $0.0001 par value            
    Additional paid-in capital [12]           66,272  
    Accumulated other comprehensive loss            
    Accumulated deficit [13]           (83,653)  
    Total Amyris, Inc. stockholders’ deficit           (17,381)  
    Noncontrolling interest            
    Total stockholders' deficit           (17,381)  
    Total liabilities, mezzanine equity and stockholders' deficit           $ (10,687)  
    Disposal Group, Not Discontinued Operation, Gain (Loss) on Disposal [25]            
    Net loss [25]       (83,653)      
    Depreciation and amortization [25]            
    (Gain) loss on disposal of property, plant and equipment [25]            
    Stock-based compensation [25]            
    Amortization of debt discount [25]       2,749      
    (Gain) loss upon extinguishment of debt [25]       10,376      
    Receipt of equity in connection with collaboration arrangements revenue [25]       2,661      
    (Gain) loss from change in fair value of derivative liabilities [25]       47,110      
    (Gain) loss on foreign currency exchange rates [25]            
    Noncash revenue reduction related to issuance of debt obligations under Ginkgo Partnership Agreement [25]       13,413      
    Non-cash gain on divestiture [25]            
    Receipt of noncash consideration in connection with license revenue [25]            
    Accounts receivable [25]            
    Accounts receivable, unbilled – related party [25]            
    Inventories [25]            
    Prepaid expenses and other assets [25]       606      
    Accounts payable [25]       (406)      
    Accrued and other liabilities [25]       6,582      
    Increase (Decrease) in Contract with Customer, Liability [25]            
    Net cash used in operating activities [25]       (562)      
    Proceeds from Divestiture of Businesses [25]            
    Change in short-term investments [25]       581      
    Change in restricted cash [25]       (865)      
    Purchases of property, plant and equipment [25]            
    Net cash (used in) provided by investing activities [25]       (284)      
    Proceeds from issuance of convertible preferred stock [25]       (2,878)      
    Proceeds from exercises of common stock options [25]       (160)      
    Payment of minimum employee taxes withheld upon net share settlement of restricted stock units [25]            
    Proceeds from issuance of common stock in August 2017 offering [25]       5,759      
    Issuance costs incurred [25]       (2,159)      
    Change in restricted cash related to contingently redeemable common stock [25]       (1,046)      
    Proceeds from issuance of debt, net of issuance costs [25]            
    Principal payments on debt [25]            
    Payment of swap termination [25]            
    Payment on early redemption of debt [25]            
    Net cash provided by financing activities [25]       (484)      
    Effect of exchange rate changes on cash, cash equivalents and restricted cash [25]            
    Net (decrease) increase in cash, cash equivalents and restricted cash [25]       (1,330)      
    Cash, cash equivalents and restricted cash at beginning of year [25]     $ 3,953 5,283      
    Cash, cash equivalents and restricted cash at end of year [25]       3,953      
    Cash and cash equivalents [25]            
    Restricted cash, current [25]            
    Restricted cash, noncurrent [25]            
    Cash paid for interest [25]            
    Issuance of common stock upon conversion of convertible notes [25]            
    Accrued interest added to debt principal [25]            
    Issuance of common stock for settlement of debt principal and interest payments [25]            
    Financing of insurance premium under note payable [25]            
    Issuance of convertible preferred stock upon conversion of debt [25]            
    Settlement of debt principal by a related party [25]            
    Issuance of note payable in exchange for debt extinguishment with third party [25]            
    Issuance of common stock for settlement of debt [25]            
    Issuance of preferred stock attributed to derivative liabilities [25]       72,725      
    Restatement Adjustment [Member] | Reclassifications [Member]              
    Revenue from Contract with Customer, Including Assessed Tax [25]            
    Cost of products sold [14],[25]            
    Research and development [15],[25]       (72)      
    Sales, general and administrative [16],[25]       72      
    Total cost and operating expenses [16],[25]            
    Loss from operations [25]            
    Disposal Group, Not Discontinued Operation, Gain (Loss) on Disposal [25]            
    Interest expense [17],[25]            
    Gain (Loss) on Derivative Instruments, Net, Pretax, Total [18],[25]            
    Gain (Loss) on Extinguishment of Debt, Total [19],[25]            
    Other income (expense), net [25]            
    Total other expense, net [25]            
    Loss before income taxes [25]            
    Provision for income taxes [20],[25]            
    Net loss [25]            
    Less deemed dividend on capital distribution to related parties [19],[25]            
    Less deemed dividend related to beneficial conversion feature on Series A preferred stock [25]            
    Less deemed dividend related to beneficial conversion feature on Series B preferred stock [25]            
    Less deemed dividend related to beneficial conversion feature on Series D preferred stock [25]            
    Less deemed dividend upon settlement of make-whole provision on Series A preferred stock [21],[25]            
    Label Less deemed dividend upon settlement of make-whole provision on Series B preferred stock [21],[25]            
    Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series A preferred stock [21],[25]            
    Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series B preferred stock [21],[25]            
    Add: losses allocated to participating securities [22],[25]            
    Net loss attributable to Amyris, Inc. common stockholders [25]            
    Basic and diluted loss per share (in dollars per share) [25]            
    Weighted-average shares of common stock outstanding used in computing net loss per share of common stock, basic and diluted (in shares) [25]            
    Non-cash gain on divestiture [25]            
    Restatement Adjustment [Member] | Reclassifications [Member] | Preferred Stock Series A and Series B [Member]              
    Less cumulative dividends on Series A and Series B preferred stock [23],[25]            
    Restatement Adjustment [Member] | Corrections [Member]              
    Revenue from Contract with Customer, Including Assessed Tax       (15,773)      
    Cost of products sold [14]       (406)      
    Research and development [15]       607      
    Sales, general and administrative [16]       562      
    Total cost and operating expenses [16]       763      
    Loss from operations       (16,536)      
    Disposal Group, Not Discontinued Operation, Gain (Loss) on Disposal            
    Interest expense [17]       (3,048)      
    Gain (Loss) on Derivative Instruments, Net, Pretax, Total [18]       (47,110)      
    Gain (Loss) on Extinguishment of Debt, Total [19]       (10,376)      
    Other income (expense), net       (1)      
    Total other expense, net       (60,535)      
    Loss before income taxes       (77,071)      
    Provision for income taxes [20]       (6,582)      
    Net loss       (83,653)      
    Less deemed dividend on capital distribution to related parties [19]       8,648      
    Less deemed dividend related to beneficial conversion feature on Series A preferred stock            
    Less deemed dividend related to beneficial conversion feature on Series B preferred stock            
    Less deemed dividend related to beneficial conversion feature on Series D preferred stock            
    Less deemed dividend upon settlement of make-whole provision on Series A preferred stock [21]       (10,505)      
    Label Less deemed dividend upon settlement of make-whole provision on Series B preferred stock [21]       (22,632)      
    Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series A preferred stock [21]       (21,578)      
    Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series B preferred stock [21]       (24,366)      
    Add: losses allocated to participating securities [22]       40,159      
    Net loss attributable to Amyris, Inc. common stockholders       $ (108,488)      
    Basic and diluted loss per share (in dollars per share)            
    Weighted-average shares of common stock outstanding used in computing net loss per share of common stock, basic and diluted (in shares)            
    Non-cash gain on divestiture            
    Restatement Adjustment [Member] | Corrections [Member] | Preferred Stock Series A and Series B [Member]              
    Less cumulative dividends on Series A and Series B preferred stock [23]       5,439      
    Restatement Adjustment [Member] | Renewable Products [Member] | Reclassifications [Member]              
    Revenue from Contract with Customer, Including Assessed Tax [25]       (3,411)      
    Restatement Adjustment [Member] | Renewable Products [Member] | Corrections [Member]              
    Revenue from Contract with Customer, Including Assessed Tax            
    Restatement Adjustment [Member] | Licenses and Royalties [Member] | Reclassifications [Member]              
    Revenue from Contract with Customer, Including Assessed Tax [24],[25]       6,774      
    Restatement Adjustment [Member] | Licenses and Royalties [Member] | Corrections [Member]              
    Revenue from Contract with Customer, Including Assessed Tax [24]       (15,774)      
    Restatement Adjustment [Member] | Grants and Collaborations [Member] | Reclassifications [Member]              
    Revenue from Contract with Customer, Including Assessed Tax [25]       (3,363)      
    Restatement Adjustment [Member] | Grants and Collaborations [Member] | Corrections [Member]              
    Revenue from Contract with Customer, Including Assessed Tax       $ 1      
    [1] Reclassification of related party accounts receivable to a separate line on the balance sheet.
    [2] Write-off of unrecoverable receivable in connection with facilities subleased to a related party.
    [3] Correction of error in recording amounts payable under Ginkgo Partnership Agreement as prepaid royalties instead of reduction in revenue.
    [4] Adjustment to uninvoiced receipts liability.
    [5] Adjustment to accrued liability.
    [6] The balance in contract liabilities at December 31, 2017 represents deferred revenue, current prior to the Company's adoption of ASC 606, "Revenue".
    [7] The balance in contract liabilities, current at December 31, 2017 represents deferred revenue, current prior to the Company's adoption of ASC 606, "Revenue".
    [8] Revision to accounting for equity received in satisfaction of a customer receivable.
    [9] Adjustment to issuance-date fair value of a debt instrument.
    [10] Make-whole derivative liabilities adjustment.
    [11] Accrual of the Ginkgo Partnership Payments obligation, net of reduction to deferred revenue liability.
    [12] Correction to the accounting for a make-whole equity instrument in connection with May 2017 equity offering.
    [13] Sum of adjustments to net loss for the year ended December 31, 2017 as result of corrections.
    [14] Correction in connection with a sales return, and adjustment to uninvoiced receipts liability.
    [15] Write-off of unrecoverable receivable in connection with facilities subleased to a related party, and reclassification of operating expense by classification to conform to the Company's current presentation.
    [16] Expense incurred in connection with May 2017 equity offering.
    [17] Correction to amortization of debt discounts, and interest expense in connection with partnership payments obligation.
    [18] Correction to accounting for make-whole liability in connection with May 2017 Offering.
    [19] Loss on extinguishment of related and unrelated party debt.
    [20] Tax provision to accrue liability for unrecognized tax benefit.
    [21] Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings.
    [22] Correction in the computation of loss per share to reflect participating securities.
    [23] Correction in the computation of net loss per share related to make-whole deemed dividends.
    [24] Ginkgo partnership obligation and promissory note issuance recorded as reduction to revenue and correction of errors in recording revenue from non-cash consideration.
    [25] Reclassification of revenue and operating expense by type to conform to the Company's current presentation.
    XML 61 R47.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 3 - Balance Sheet Details - Inventory, Current (Details) - USD ($)
    $ in Thousands
    Dec. 31, 2018
    Dec. 31, 2017
    Raw materials $ 3,901 $ 819
    Work in process 539 364
    Finished goods 5,253 4,225
    Total inventories $ 9,693 $ 5,408
    XML 62 R3.htm IDEA: XBRL DOCUMENT v3.19.3
    Consolidated Balance Sheets (Parentheticals) - USD ($)
    $ in Thousands
    Dec. 31, 2018
    Dec. 31, 2017
    Accounts receivable, allowance $ 642 $ 619
    Accounts receivable, related party, allowance 0 23
    Debt, current portion, fair value $ 57,918 $ 0
    Preferred stock, par value (in dollars per share) $ 0.0001 $ 0.0001
    Preferred stock, shares authorized (in shares) 5,000,000 5,000,000
    Preferred stock, shares issued (in shares) 14,656 22,171
    Preferred stock, shares outstanding (in shares) 14,656 22,171
    Common stock, par value (in dollars per share) $ 0.0001 $ 0.0001
    Common stock, shares authorized (in shares) 250,000,000 250,000,000
    Common stock, shares issued (in shares) 76,564,829 45,637,433
    Common stock, shares outstanding (in shares) 76,564,829 45,637,433
    XML 63 R68.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 8 - Net Loss Per Share Attributable to Common Stockholders - Antidilutive Securities Excluded From Computation of Earnings Per Share (Details) - shares
    12 Months Ended
    Dec. 31, 2018
    Dec. 31, 2017
    Antidilutive securities (in shares) 53,332,381 44,653,251
    Period-end Common Stock Warrants [Member]    
    Antidilutive securities (in shares) 25,986,370 29,921,844
    Convertible Promissory Notes [Member]    
    Antidilutive securities (in shares) [1] 13,703,162 8,203,821
    Stock Options to Purchase Common Stock [Member]    
    Antidilutive securities (in shares) 5,392,269 1,338,367
    Restricted Stock Units (RSUs) [Member]    
    Antidilutive securities (in shares) 5,294,848 685,007
    Period-end Preferred Shares [Member]    
    Antidilutive securities (in shares) 2,955,732 4,504,212
    [1] The potentially dilutive effect of convertible promissory notes was computed based on conversion ratios in effect at the respective year-end. A portion of the convertible promissory notes issued carries a provision for a reduction in conversion price under certain circumstances, which could potentially increase the dilutive shares outstanding. Another portion of the convertible promissory notes issued carries a provision for an increase in the conversion rate under certain circumstances, which could also potentially increase the dilutive shares outstanding.
    XML 64 R98.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 15 - Geographical Information - Long-lived Assets by Geography (Details) - USD ($)
    $ in Thousands
    Dec. 31, 2018
    Dec. 31, 2017
    Long-Lived Assets $ 19,756 $ 13,892
    UNITED STATES    
    Long-Lived Assets 13,111 10,357
    BRAZIL    
    Long-Lived Assets 6,447 3,357
    Europe [Member]    
    Long-Lived Assets $ 198 $ 178
    XML 65 R94.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 14 - Income Taxes - Effective Tax Rate Reconciliation (Details)
    12 Months Ended
    Dec. 31, 2018
    Dec. 31, 2017
    Statutory tax rate (21.00%) (34.00%)
    State taxes, net of federal tax benefit
    Stock-based compensation
    Federal R&D credit (0.60%) (0.20%)
    Derivative liability 4.30% 13.90%
    Nondeductible interest 1.00% 3.00%
    Other (0.10%) (0.20%)
    Foreign losses 0.90% 8.50%
    Change in U.S. federal tax rate 25.10%
    IRC Section 382 limitation 7.20%
    Change in valuation allowance 15.50% (18.60%)
    Effective income tax rate 4.70%
    XML 66 R64.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 7 - Stockholders' Deficit (Details Textual)
    1 Months Ended 3 Months Ended 12 Months Ended
    May 03, 2019
    USD ($)
    Apr. 29, 2019
    USD ($)
    $ / shares
    shares
    Apr. 26, 2019
    USD ($)
    Apr. 16, 2019
    USD ($)
    Mar. 29, 2019
    USD ($)
    Nov. 20, 2018
    USD ($)
    $ / shares
    shares
    Nov. 19, 2018
    USD ($)
    $ / shares
    shares
    Oct. 19, 2018
    shares
    Apr. 12, 2018
    USD ($)
    $ / shares
    shares
    Oct. 28, 2017
    USD ($)
    Aug. 07, 2017
    USD ($)
    $ / shares
    shares
    Aug. 03, 2017
    USD ($)
    $ / shares
    shares
    Aug. 03, 2017
    USD ($)
    $ / shares
    shares
    Mar. 08, 2016
    USD ($)
    Nov. 30, 2018
    USD ($)
    Aug. 31, 2018
    USD ($)
    $ / shares
    shares
    Dec. 31, 2017
    USD ($)
    $ / shares
    shares
    Aug. 31, 2017
    USD ($)
    May 31, 2017
    USD ($)
    $ / shares
    shares
    Jul. 31, 2015
    USD ($)
    $ / shares
    shares
    Dec. 31, 2018
    USD ($)
    $ / shares
    shares
    Dec. 31, 2017
    USD ($)
    $ / shares
    shares
    Dec. 31, 2018
    USD ($)
    $ / shares
    shares
    Dec. 31, 2017
    USD ($)
    $ / shares
    shares
    Mar. 28, 2019
    USD ($)
    $ / shares
    Jul. 31, 2018
    $ / shares
    Class of Warrants or Right, Issued in Period | shares                                             17,898,107      
    Stock Issued During Period, Shares, Warrants Exercised | shares                                             20,928,439      
    Proceeds from Warrant Exercises                                             $ 57,767,000    
    Derivative Liability, Total                                 $ 116,497,000       $ 42,796,000 $ 116,497,000 $ 42,796,000 $ 116,497,000    
    Share Price | $ / shares                                 $ 3.75       $ 3.34 $ 3.75 $ 3.34 $ 3.75    
    Proceeds from Issuance of Common Stock                                             $ 5,759,000    
    Extinguishment of Debt, Amount                                     $ 40,200,000              
    Preferred Stock, Shares Outstanding, Ending Balance | shares                                 22,171       14,656 22,171 14,656 22,171    
    Adjustments to Additional Paid in Capital, Dividends in Excess of Retained Earnings                                     8,600,000              
    Gain (Loss) on Extinguishment of Debt, Total                                     $ (1,900,000)       $ (17,424,000) $ (11,897,000) [1]    
    Payments of Stock Issuance Costs                                             2,159,000    
    Deemed Dividend Related to Proceeds Discount and Issuance Costs Upon Conversion of Series B Preferred Stock                                             24,366,000 [2]    
    Adjustments to Additional Paid in Capital, Other                                         $ 6,800,000          
    Proceeds from Issuance of Private Placement                                             1,415,000    
    Revenue from Contract with Customer, Including Assessed Tax                                             63,604,000 127,671,000    
    Preferred Stock, Value, Issued, Ending Balance                                          
    Gain (Loss) on Derivative Instruments, Net, Pretax, Total                                             (30,880,000) (48,852,000) [3]    
    Revenues, Total                                             63,604,000 127,671,000    
    Deemed Dividend, Beneficial Conversion Feature on Series A Preferred Stock                                             $ 562,000    
    Preferred Stock, Par or Stated Value Per Share | $ / shares                                 $ 0.0001       $ 0.0001 $ 0.0001 $ 0.0001 $ 0.0001    
    Stock Issued During Period, Value, New Issues                                             $ 1,415,000      
    Common Stock, Shares, Outstanding, Ending Balance | shares                                 45,637,433       76,564,829 45,637,433 76,564,829 45,637,433    
    Foris and Naxyris [Member]                                                    
    Conversion of Stock, Shares Converted | shares                                     1,394,706              
    Affiliated Entity [Member]                                                    
    Stock Issued During Period, Shares, New Issues | shares                                       1,068,379            
    Common Stock [Member]                                                    
    Stock Issued During Period, Shares, Warrants Exercised | shares                                             20,891,038 3,148,097    
    Stock Issued During Period, Shares, New Issues | shares                                             205,168 2,826,711    
    Stock Issued During Period, Value, New Issues                                                  
    Embedded Derivative Financial Instruments [Member]                                                    
    Class of Warrant or Right, Securities Called by Warrants As Percentage of Shares Purchased By Investor                                         100.00%   100.00%      
    Series A Preferred Stock Converted Into Common Stock [Member]                                                    
    Conversion of Stock, Shares Converted | shares                                             22,140      
    Series B Preferred Stock Converted Into Common Stock [Member]                                                    
    Conversion of Stock, Shares Converted | shares                                             89,528      
    Due to Related Parties [Member]                                                    
    Extinguishment of Debt, Amount                                     $ 33,100,000              
    Due to Related Parties [Member] | Foris Ventures, LLC [Member]                                                    
    Extinguishment of Debt, Amount                                     27,000,000              
    Due to Related Parties [Member] | Naxyris S.A. [Member]                                                    
    Extinguishment of Debt, Amount                                     $ 2,000,000              
    Series A Preferred Stock [Member]                                                    
    Preferred Stock, Capital Shares Reserved for Future Issuance | shares                                     22,140              
    Preferred Stock, Dividend Rate, Percentage                                     17.38%              
    Preferred Stock, Stated Value | $ / shares                                     $ 1,000              
    Preferred Stock, Conversion Price Per Share to Common Stock | $ / shares                                     17.25              
    Preferred Stock, Anniversary Payment | $ / shares                                     $ 1,738              
    Preferred Stock, Shares Outstanding, Ending Balance | shares                                         0   0      
    Adjustments to Additional Paid in Capital, Deemed Dividends on Preferred Stock Discounts Upon Conversion of Preferred Stock                                             $ 21,578,000    
    Stockholders' Equity, Deemed Dividend Upon Settlement of Make-whole Provision on Series A Preferred Stock                                   $ 10,500,000         10,505,000    
    Stock Issued During Period, Value, New Issues                                               562,000    
    Series A Preferred Stock [Member] | Common Stock [Member]                                                    
    Adjustments to Additional Paid in Capital, Deemed Dividends on Preferred Stock Discounts Upon Conversion of Preferred Stock                                                  
    Stockholders' Equity, Deemed Dividend Upon Settlement of Make-whole Provision on Series A Preferred Stock                                                  
    Stock Issued During Period, Value, New Issues                                                  
    Series A Preferred Stock [Member] | Minimum [Member]                                                    
    Beneficiary Ownership, Conversion Percentage, Maximum                                     4.99%              
    Series A Preferred Stock [Member] | Maximum [Member]                                                    
    Beneficiary Ownership, Conversion Percentage, Maximum                                     9.99%              
    Series B Preferred Stock [Member]                                                    
    Preferred Stock, Capital Shares Reserved for Future Issuance | shares                                     70,904              
    Preferred Stock, Dividend Rate, Percentage                                     17.38%              
    Preferred Stock, Shares Outstanding, Ending Balance | shares                                 9,213       6,376 9,213 6,376 9,213    
    Adjustments to Additional Paid in Capital, Deemed Dividends on Preferred Stock Discounts Upon Conversion of Preferred Stock                                             $ 24,366,000    
    Stockholders' Equity, Deemed Dividend Upon Settlement of Make-whole Provision on Series A Preferred Stock                                             22,632,000    
    Stock Issuance Costs Recognized                                             1,200,000      
    Stock Issued During Period, Value, New Issues                                               16,675,000    
    Series B Preferred Stock [Member] | Common Stock [Member]                                                    
    Adjustments to Additional Paid in Capital, Deemed Dividends on Preferred Stock Discounts Upon Conversion of Preferred Stock                                                  
    Stockholders' Equity, Deemed Dividend Upon Settlement of Make-whole Provision on Series A Preferred Stock                                                  
    Stock Issued During Period, Value, New Issues                                                  
    Series B Preferred Stock [Member] | Foris Ventures, LLC [Member]                                                    
    Debt Conversion, Converted Instrument, Shares Issued | shares                                     30,729              
    Debt Conversion, Converted Instrument, Warrants or Options Issued | shares                                     4,877,386              
    Series B Preferred Stock [Member] | Naxyris S.A. [Member]                                                    
    Debt Conversion, Converted Instrument, Shares Issued | shares                                     2,333              
    Debt Conversion, Converted Instrument, Warrants or Options Issued | shares                                     370,404              
    Series A and Series B Preferred Stock [Member]                                                    
    Convertible Debt, Aggregate Number of Shares Issued With Respect to the Initial Closing, Maximum | shares                                     3,792,778              
    Embedded Derivative, Fair Value of Embedded Derivative Liability                                     $ 11,000,000   $ 10,600,000   $ 10,600,000      
    Convertible Preferred Stock, Beneficial Conversion Feature, Proceeds Allocated to Preferred Stock                                     600,000              
    Convertible Preferred Stock, Proceeds Allocated to Preferred Stock                                     $ 600,000              
    Series D Preferred Stock [Member]                                                    
    Preferred Stock, Stated Value | $ / shares                       $ 1,000 $ 1,000                          
    Preferred Stock, Conversion Price Per Share to Common Stock | $ / shares                       $ 4.26 $ 4.26                          
    Preferred Stock, Shares Outstanding, Ending Balance | shares                                 12,958       8,280 12,958 8,280 12,958    
    Adjustments to Additional Paid in Capital, Deemed Dividends on Preferred Stock Discounts Upon Conversion of Preferred Stock                                             $ 6,852,000    
    Payments of Stock Issuance Costs                       $ 200,000                            
    Common Stock, Dividends, Per Share, Declared | $ / shares                       $ 0.0001                            
    Dividends, Preferred Stock, Total                                             $ 0      
    Preferred Stock, Beneficial Conversion Feature                       $ 5,800,000                            
    Deemed Dividend, Beneficial Conversion Feature on Series A Preferred Stock                                           $ 5,800,000        
    Preferred Stock, Beneficial Ownership Limitation                                         9.99%   9.99%      
    Stock Issued During Period, Value, New Issues                                               6,197,000    
    Series D Preferred Stock [Member] | Common Stock [Member]                                                    
    Adjustments to Additional Paid in Capital, Deemed Dividends on Preferred Stock Discounts Upon Conversion of Preferred Stock                                                  
    Stock Issued During Period, Value, New Issues                                                  
    Series C Preferred Stock [Member]                                                    
    Preferred Stock, Stated Value | $ / shares                                     $ 1,000              
    Preferred Stock, Conversion Price Per Share to Common Stock | $ / shares                                     $ 15              
    Series C Preferred Stock [Member] | Conversion of Common Stock Into Series C Preferred Stock [Member] | Foris and Naxyris [Member]                                                    
    Conversion of Stock, Shares Issued | shares                                     20,921              
    DSM Supply Agreement [Member]                                                    
    Stock Issued During Period, Shares, New Issues | shares             1,643,991,000,000                                      
    Stock Issued During Period, Value, New Issues             $ 6,100,000                                      
    Subsequent Event [Member]                                                    
    Share Price | $ / shares                                                 $ 2.10  
    Subsequent Event [Member] | DSM Supply Agreement [Member]                                                    
    Shares Issued, Price Per Share | $ / shares                                                 $ 4.41  
    Stock Issued During Period, Value, New Issues         $ 7,300,000                                          
    DSM International B.V. [Member]                                                    
    Adjustments to Additional Paid in Capital, Other                                     $ 600,000              
    Warrants and Rights Outstanding                                   $ 10,600,000                
    Payments for Legal Settlements                                             6,800,000      
    Designated Holder Maximum Common Stock Ownership                                   33.00%                
    Second Tranche Closing, Anniversary Payment                                   $ 5,000,000                
    Reserved Second Tranche Securities                                   25,000,000                
    Proceeds from Issuance of Private Placement                                   25,900,000                
    Credit Letter                                   7,100,000                
    Consideration Transferred                         $ 34,000,000         34,000,000                
    Equity Conversion Feature Embedded Derivative Liability Fair Value Disclosures                                   $ 0                
    Gain (Loss) on Derivative Instruments, Net, Pretax, Total                                               (4,000,000)    
    Reversal of Remaining Unrecognized Deferred Revenue Liability                                 $ 4,500,000                  
    DSM International B.V. [Member] | Measurement Input, Discount Rate [Member]                                                    
    Debt Instrument, Measurement Input                                   0.086                
    DSM International B.V. [Member] | License [Member]                                                    
    Revenue from Contract with Customer, Including Assessed Tax                                 27,500,000             54,600,000    
    DSM International B.V. [Member] | Designated Director One [Member]                                                    
    Designated Director, Minimum Beneficial Ownership Level                                   4.50%                
    DSM International B.V. [Member] | Designated Director Two [Member]                                                    
    Designated Director, Minimum Beneficial Ownership Level                                   10.00%                
    DSM International B.V. [Member] | Minimum [Member]                                                    
    Credit Utilization Likelihood Percentage                                   50.00%                
    DSM International B.V. [Member] | Maximum [Member]                                                    
    Credit Utilization Likelihood Percentage                                   90.00%                
    DSM International B.V. [Member] | Series B Preferred Stock [Member]                                                    
    Embedded Derivative, Fair Value of Embedded Derivative Liability                                     $ 12,400,000   $ 11,900,000   11,900,000      
    Stockholders' Equity, Deemed Dividend Upon Settlement of Make-whole Provision on Series A Preferred Stock                             $ 22,600,000                      
    Payments of Stock Issuance Costs                                   $ 200,000         200,000      
    Deemed Dividend Related to Proceeds Discount and Issuance Costs Upon Conversion of Series B Preferred Stock                                             $ 24,400,000      
    Preferred Stock, Value, Issued, Ending Balance                                   $ 15,600,000                
    DSM International B.V. [Member] | Series B Convertible Preferred Stock [Member]                                                    
    Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                                         $ 4.40   $ 4.40      
    Stock Issued During Period, Shares, New Issues | shares                     25,000                              
    Share Price | $ / shares                     $ 1,000                              
    Proceeds from Issuance of Convertible Preferred Stock                     $ 25,900,000                              
    DSM International B.V. [Member] | Intellectual Property License [Member]                                                    
    Revenues, Total                                             $ 7,800,000      
    Liability Reversal For The Consideration Recorded Related to Deferred Revenue Now Being Terminated                                               3,300,000    
    DSM International B.V. [Member] | Intellectual Property License [Member] | License [Member]                                                    
    Revenue from Contract with Customer, Including Assessed Tax                   $ 9,000,000                                
    DSM International B.V. [Member] | Subsequent Event [Member]                                                    
    Extinguishment of Debt, Amount       $ 27,900,000                                            
    Consideration Transferred       $ 57,000,000                                            
    Foris and Naxyris [Member] | Series C Preferred Stock [Member]                                                    
    Preferred Stock, Par or Stated Value Per Share | $ / shares                                     $ 0.0001              
    Private Placement [Member] | Subsequent Event [Member]                                                    
    Proceeds from Issuance of Common Stock $ 5,000,000 $ 5,800,000 $ 23,200,000                                              
    Private Placement [Member] | DSM [Member]                                                    
    Stock Issued During Period, Shares, New Issues | shares           1,643,991                                        
    Shares Issued, Price Per Share | $ / shares           $ 3.68                                        
    Derivative Liability, Total           $ 1,200,000                             $ 1,800,000   1,800,000      
    Gain (Loss) From Fair Value Adjustment in Collaboration Agreement                                             $ 600,000      
    Private Placement [Member] | DSM [Member] | Subsequent Event [Member]                                                    
    Derivative Liability, Total                                                 $ 3,800,000  
    Private Placement [Member] | Vivo Capital LLC [Member] | Subsequent Event [Member]                                                    
    Stock Issued During Period, Shares, New Issues | shares   913,529                                                
    Shares Issued, Price Per Share | $ / shares   $ 4.76                                                
    At the Market Offering [Member]                                                    
    Stock Issued During Period, Shares, New Issues | shares                                             205,168      
    Common Stock, Value, Subscriptions                           $ 50,000,000     $ 0       $ 0 $ 0 $ 0 0    
    Commission Rate                           3.00%                        
    Proceeds from Issuance of Common Stock                                             $ 1,400,000      
    At The Market Offering, Six Months Ended [Member]                                                    
    Shares Issued, Price Per Share | $ / shares                                         $ 6.90   $ 6.90      
    May 2017 Offering Closing [Member]                                                    
    Proceeds from Issuance or Sale of Equity, Total                                     $ 50,700,000              
    May 2017 Offering Closing [Member] | Series A Preferred Stock and Warrants [Member]                                                    
    Proceeds from Issuance or Sale of Equity, Total                                     22,100,000              
    May 2017 Offering Closing [Member] | Series B Preferred Stock and Warrants [Member]                                                    
    Proceeds from Issuance or Sale of Equity, Total                                     30,700,000              
    Securities Purchase Agreement [Member] | Vivo Capital LLC [Member]                                                    
    Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                       $ 6.39 $ 6.39                          
    Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares                       5,575,118 5,575,118                          
    Stock Issued During Period, Shares, New Issues | shares                       2,826,711                            
    Shares Issued, Price Per Share | $ / shares                       $ 4.26 $ 4.26                          
    Proceeds from Issuance of Common Stock                       $ 24,800,000                            
    Class of Warrant or Right, Term                       5 years                            
    Securities Purchase Agreement [Member] | Vivo Capital LLC [Member] | Series D Convertible Preferred Stock [Member]                                                    
    Stock Issued During Period, Shares, New Issues | shares                       12,958                            
    Share Price | $ / shares                       $ 1,000 $ 1,000                          
    August 2013 Convertible Notes [Member]                                                    
    Debt Instrument, Convertible, Conversion Price | $ / shares                               $ 4.40                   $ 5.2977
    March 2014 Letter Agreement [Member]                                                    
    Debt Conversion, Original Debt, Amount                                     3,400,000              
    Gain (Loss) on Extinguishment of Debt, Total                                               (1,800,000)    
    Conversion of All Outstanding Fidelity Notes for Aggregate Principal Amount of 2015 144A Notes [Member]                                                    
    Debt Conversion, Original Debt, Amount                                     3,700,000              
    Gain (Loss) on Extinguishment of Debt, Total                                               $ 2,000,000    
    The DSM Credit Letter [Member] | DSM International B.V. [Member] | Minimum [Member]                                                    
    Debt Instrument, Term                                   1 year 180 days                
    The DSM Credit Letter [Member] | DSM International B.V. [Member] | Maximum [Member]                                                    
    Debt Instrument, Term                                   4 years                
    May 2017 Warrants [Member]                                                    
    Class of Warrants or Right, Issued in Period | shares                 3,616,174                           8,523,560 0    
    Proceeds from Issuance of Warrants                 $ 14,500,000                                  
    Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                 $ 7               $ 4.40       $ 4.40 $ 4.40 $ 4.40 $ 4.40    
    Derivative Liability, Total                                     $ 39,500,000              
    Fair Value Adjustment of Warrants                                             $ 13,500,000 $ 40,400,000    
    Class of Warrant or Right, Term                                             5 years      
    Warrants and Rights Outstanding                                         $ 24,100,000   $ 24,100,000      
    Cash Warrants and Dilution Warrants [Member]                                                    
    Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                               $ 4.40                   $ 6.39
    Stock Issued During Period, Shares, Warrants Exercised | shares                               12,600,000                    
    Proceeds from Warrant Exercises                               $ 43,000,000                    
    August 2018 New Warrants [Member]                                                    
    Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                               $ 7.52                    
    Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares                               12.1                    
    Temasek Funding Warrant [Member]                                                    
    Stock Issued During Period, Shares, Warrants Exercised | shares               1,852,585                                    
    Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares                                         471,204   471,204      
    Class of Warrant or Right, Additional Number of Securities Called by Warrants or Rights | shares                               471,204                    
    Class Of Warrant Or Right, Cashless Exercise Provision, Number Exercised | shares               1,889,986                                    
    Increase (Decrease) in Derivative Liabilities                                             $ 14,000,000      
    May 2017 Warrants, Warrant 1 [Member]                                                    
    Class of Warrants or Right, Issued in Period | shares                                             14,768,380      
    Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                                     $ 7.80              
    Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares                                     7,384,190              
    Class of Warrant or Right, Dilution Period                                             3 years      
    May 2017 Warrants, Warrant 2 [Member]                                                    
    Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                                     $ 9.30              
    Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares                                     7,384,190              
    May 2017 Dilution Warrants [Member]                                                    
    Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                                         $ 0.0015   $ 0.0015      
    Dilution Warrants [Member]                                                    
    Class of Warrants or Right, Issued in Period | shares                                             6,377,466      
    Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                                         4.40   $ 4.40      
    Stock Issued During Period, Shares, Warrants Exercised | shares                                             6,329,488      
    Preferred Stock Effective Conversion Price | $ / shares                                         $ 6.30   $ 6.30      
    Fair Value Adjustment of Warrants                                             $ 64,100,000      
    DSM Warrants [Member] | DSM International B.V. [Member]                                                    
    Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares             $ 4.40       $ 6.30                              
    Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares                     3,968,116                              
    Class of Warrant or Right, Term                     5 years                              
    DSM Dilution Warrant [Member] | DSM International B.V. [Member]                                                    
    Class of Warrant or Right, Number of Securities Called by Warrants or Rights | shares                                         1,713,565   1,713,565      
    Preferred Stock Effective Conversion Price | $ / shares                     $ 6.30                              
    Class of Warrant or Right, Term                     5 years                              
    Common Stock, Dividends, Per Share, Declared | $ / shares                     $ 0.10                              
    Cash Warrants [Member] | DSM International B.V. [Member]                                                    
    Stock Issued During Period, Shares, Warrants Exercised | shares                                             0      
    Warrants and Rights Outstanding                                   $ 10,600,000                
    Revenues, Total                                   $ 7,800,000                
    Vivo Cash Warrants [Member]                                                    
    Fair Value Adjustment of Warrants                                             $ 7,700,000 3,000,000    
    Warrants and Rights Outstanding                       $ 13,000,000 $ 13,000,000       $ 12,000,000         $ 12,000,000   12,000,000    
    Vivo Cash Warrants [Member] | Common Stock [Member]                                                    
    Warrants and Rights Outstanding                       $ 5,600,000 $ 5,600,000       $ 25,000,000         $ 25,000,000   $ 25,000,000    
    August 2017 Vito Dilution Warrants [Member]                                                    
    Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                               $ 4.40                    
    Stock Issued During Period, Shares, Warrants Exercised | shares                                         4,678     0    
    Class Of Warrant Or Right, Cashless Exercise Provision, Number Exercised | shares                                             5,575,118      
    Preferred Stock Effective Conversion Price | $ / shares                       $ 4.26 $ 4.26                          
    Class of Warrant or Right, Term                       5 years                            
    Designated Holder Maximum Common Stock Ownership                       33.00%                            
    Minimum Beneficial Ownership Level to Designate a Director                       4.50%                            
    July 2015 PIPE Warrants [Member] | Affiliated Entity [Member]                                                    
    Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                                 $ 0.15         $ 0.15   $ 0.15    
    Stock Issued During Period, Shares, Warrants Exercised | shares                                               25,643    
    Share Price | $ / shares                                       $ 23.40            
    Class of Warrant or Right, Securities Called by Warrants As Percentage of Shares Purchased By Investor                                 10.00%         10.00%   10.00%    
    Stock Issued During Period, Value, New Issues                                       $ 25,000,000            
    Common Stock, Shares, Outstanding, Ending Balance | shares                                 81,197         81,197   81,197    
    [1] Loss on extinguishment of related and unrelated party debt.
    [2] Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings.
    [3] Correction to accounting for make-whole liability in connection with May 2017 Offering.
    XML 67 R60.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 5 - Debt (Details Textual) - USD ($)
    1 Months Ended 3 Months Ended 12 Months Ended 18 Months Ended
    Jul. 26, 2019
    Jul. 24, 2019
    Jul. 02, 2019
    Jun. 24, 2019
    May 15, 2019
    Dec. 10, 2018
    Dec. 06, 2018
    Nov. 08, 2018
    Oct. 16, 2018
    Jun. 29, 2018
    Dec. 28, 2017
    Feb. 15, 2016
    May 31, 2019
    Dec. 31, 2018
    Nov. 30, 2018
    Jul. 02, 2018
    Mar. 31, 2018
    Dec. 31, 2017
    May 31, 2017
    Feb. 28, 2017
    Jan. 31, 2017
    Dec. 31, 2016
    Oct. 31, 2015
    Jul. 31, 2015
    May 31, 2014
    Jan. 31, 2014
    Oct. 31, 2013
    Jul. 02, 2018
    Dec. 31, 2018
    Dec. 31, 2017
    Nov. 30, 2015
    Jan. 14, 2019
    Aug. 31, 2018
    Jul. 31, 2018
    Nov. 30, 2017
    Aug. 31, 2017
    Oct. 31, 2016
    Mar. 31, 2016
    Feb. 29, 2016
    Mar. 31, 2014
    Aug. 31, 2013
    Jun. 30, 2012
    Debt Instrument, Unamortized Discount, Total                           $ 17,100,000                             $ 17,100,000                          
    Debt, Changes in Fair Value, Gain (Loss)                                                         2,082,000                        
    Gain (Loss) on Extinguishment of Debt, Total                                     $ (1,900,000)                   (17,424,000) (11,897,000) [1]                        
    Repayments of Long-term Debt, Total                                                         41,668,000 37,500,000                        
    Long-term Debt, Gross                           228,921,000       $ 195,819,000                     228,921,000 195,819,000                        
    Long-term Debt, Total                           209,697,000       163,704,000                     209,697,000 163,704,000                        
    Debt Instrument, Fair Value Disclosure, Total                           149,300,000       156,900,000                     149,300,000 156,900,000                        
    Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net, Total                           17,100,000                             17,100,000                          
    Interest Expense, Total                                                         42,703,000 37,081,000 [2]                        
    Proceeds from Issuance of Private Placement                                                         1,415,000                        
    Letters of Credit Outstanding, Amount                                                                                   $ 1,000,000
    Restricted Cash and Cash Equivalents, Noncurrent, Total                           960,000       959,000                     960,000 959,000                        
    Private Placement February 2016 [Member]                                                                                    
    Debt Instrument, Interest Rate, Stated Percentage                       13.50%                                                            
    DSM Credit Agreement [Member]                                                                                    
    Debt Instrument, Interest Rate, Stated Percentage                     10.00%                                                              
    Line of Credit Facility, Maximum Borrowing Capacity                     $ 25,000,000             25,000,000                       25,000,000                        
    Proceeds from Long-term Lines of Credit                     25,000,000                                                              
    Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net, Total                     $ 8,000,000                                                              
    Letter of Credit [Member]                                                                                    
    Restricted Cash and Cash Equivalents, Noncurrent, Total                           $ 1,000,000       1,000,000                     $ 1,000,000 $ 1,000,000                        
    Foris Ventures, LLC [Member] | Private Placement February 2016 [Member]                                                                                    
    Class of Warrant or Right, Number of Securities Called by Warrants or Rights                       152,381                                                            
    Proceeds from Issuance of Private Placement                       $ 16,000,000                                                            
    Naxyris S.A. [Member] | Private Placement February 2016 [Member]                                                                                    
    Class of Warrant or Right, Number of Securities Called by Warrants or Rights                       19,048                                                            
    Proceeds from Issuance of Private Placement                       $ 2,000,000                                                            
    Biolding Investment SA [Member] | Private Placement February 2016 [Member]                                                                                    
    Class of Warrant or Right, Number of Securities Called by Warrants or Rights                       19,048                                                            
    Proceeds from Issuance of Private Placement                       $ 2,000,000                                                            
    The February 2016 Warrants [Member]                                                                                    
    Class of Warrant or Right, Number of Securities Called by Warrants or Rights                           171,429                             171,429                          
    Class of Warrant or Right, Term                                                           5 years                        
    Class of Warrant or Right, Exercises During the Period                                                         0                          
    Related Party Convertible Notes [Member]                                                                                    
    Debt, Changes in Fair Value, Gain (Loss)                                                                                  
    Debt Instrument Covenant Terms Minimum Amount Of Transactions Requiring Consent Of Noteholders                           $ 20,000,000                             20,000,000                          
    Long-term Debt, Gross                           24,705,000       50,116,000                     24,705,000 $ 50,116,000                        
    Long-term Debt, Total                           $ 23,667,000       47,211,000                     $ 23,667,000 47,211,000                        
    Unsecured Promissory Notes, 2016 [Member] | Private Placement February 2016 [Member]                                                                                    
    Debt Instrument, Face Amount                                                                             $ 20,000,000      
    Class of Warrant or Right, Number of Securities Called by Warrants or Rights                           190,477                             190,477                          
    Class of Warrant or Right, Exercise Price of Warrants or Rights                           $ 0.15                             $ 0.15                          
    Proceeds from Issuance of Private Placement                       $ 20,000,000                                                            
    Subsequent Event [Member] | Warrants in Connection of Extinguishment of Tranche II Note [Member]                                                                                    
    Class of Warrant or Right, Number of Securities Called by Warrants or Rights     1,080,000                                                                              
    Subsequent Event [Member] | Common Stock Issued upon Extinguishment of Tranche II Note [Member]                                                                                    
    Debt Conversion, Converted Instrument, Shares Issued     1,767,632                                                                              
    Series A Preferred Stock [Member]                                                                                    
    Preferred Stock, Dividend Rate, Percentage                                     17.38%                                              
    Total and Temasek [Member] | Common Stock Issued Upon Conversion of Convertible Notes [Member]                                                                                    
    Debt Instrument, Convertible, Conversion Price                                               $ 34.50                                    
    Total [Member]                                                                                    
    Debt Instrument, Repurchase Amount                                                                           $ 3,700,000        
    Convertible Senior Notes, 6.0% Due in 2021 [Member]                                                                                    
    Debt Instrument, Face Amount           $ 60,000,000 $ 60,000,000                                                                      
    Debt Instrument, Interest Rate, Stated Percentage           6.00% 6.00%             6.00%                             6.00%                          
    Proceeds from Convertible Debt           $ 56,200,000                                                                        
    Debt Instrument, Convertible, Conversion Price             $ 6.32                                                                      
    Debt Instrument, Periodic Payment, Cash Percentage of Each Installment Amount             108.00%                                                                      
    Debt Instrument, Covenant Terms, Minimum Cash Amount Redeemed Percentage Upon Default             125.00%                                                                      
    Debt Instrument, Covenant Terms, Minimum Cash Amount Redeemed Percentage Upon Fundamental Transaction             125.00%                                                                      
    Convertible Debt, Beneficial Common Stock Ownership, Maximum Percentage Except Under Specified Conditions             4.99%                                                                      
    Convertible Debt, Beneficial Common Stock Ownership, Maximum Percentage Under Specified Conditions             9.99%                                                                      
    Convertible Debt, Beneficial Common Stock Ownership, Maximum Percentage, Conditions, Number of Days After Written Notice             61 days                                                                      
    Convertible Debt, Aggregate Number of Shares Issued With Respect to the Initial Closing, Maximum             15,271,047                                                                      
    Debt Instrument, Covenant Terms, Percent of Principal Compensation to be Paid             2.00%                                                                      
    Debt, Changes in Fair Value, Gain (Loss)                                                         $ 2,100,000                          
    Long-term Debt, Gross                           $ 60,000,000                             $ 60,000,000                          
    Convertible Senior Notes, 6.0% Due in 2021 [Member] | Subsequent Event [Member]                                                                                    
    Debt Conversion, Original Debt, Amount $ 4,700,000 $ 53,300,000   $ 4,700,000 $ 53,300,000                                                                          
    Rule 144A Convertible Note Offering [Member]                                                                                    
    Debt Instrument, Face Amount                                             $ 57,600,000                                      
    Debt Instrument, Interest Rate, Stated Percentage                                             9.50%                                      
    Proceeds from Convertible Debt                                             $ 54,400,000   $ 72,000,000                                  
    Debt Instrument, Convertible, Conversion Price                           $ 56.16                             $ 56.16                          
    Convertible Note Offering                                                 $ 75,000,000                                  
    Debt Instrument, Interest Rate, Effective Percentage                                                 6.50%                                  
    Rule 144A Convertible Note Offering [Member] | Subsequent Event [Member]                                                                                    
    Debt Conversion, Original Debt, Amount                         $ 38,200,000                                                          
    Rule 144A Convertible Note Offering [Member] | Denominator [Member]                                                                                    
    Debt Instrument, Convertible, Conversion Rate, Principle Amount                                                         $ 1,000                          
    Rule 144A Convertible Note Offering [Member] | Reverse Stock Split [Member]                                                                                    
    Debt Instrument, Convertible, Conversion Ratio                                                         17.8073                          
    Rule 144A Convertible Note Offering [Member] | Affiliated Entity [Member]                                                                                    
    Debt Instrument, Repurchase Amount                                             18,300,000                                      
    Debt Instrument, Repurchased Face Amount                                             $ 22,900,000                                      
    Convertible Senior Notes, 9.5% [Member]                                                                                    
    Debt Instrument, Interest Rate, Stated Percentage                                             9.50%                                      
    Debt Instrument, Convertible, Conversion Price                           $ 16.20                             $ 16.20                          
    Debt Instrument, Interest, Payable in Common Stock, Percentage of Market-based Price                                             92.50%                                      
    Debt Instrument, Convertible, Conversion Rate, Shares                                                         61.7246                          
    Debt Instrument, Convertible, Conversion Rate, Principle Amount                                                         $ 1,000                          
    Convertible Note Substantial Change, Discount Rate Used in Calculate Value of Remaining Interest Payments                           0.75%                             0.75%                          
    Debt Instrument, Convertible Percentage of Average Price Per Share the Stock will be Valued upon Early Conversion                                                         92.50%                          
    Convertible Promissory Note, Additional Principal Amount Issued During Period                                         $ 19,100,000                                          
    Debt Instrument, Decrease, Forgiveness                                         $ 15,300,000                                          
    Shares Issuable with Respect to Debt Instrument, Maximum Number of Shares of Common Stock Without Prior Approval                                         3,652,935                                          
    Gain (Loss) on Extinguishment of Debt, Total                                                           100,000                        
    Conversion of All Outstanding Fidelity Notes for Aggregate Principal Amount of 2015 144A Notes [Member]                                                                                    
    Gain (Loss) on Extinguishment of Debt, Total                                                           2,000,000                        
    Debt Conversion, Original Debt, Amount                                     $ 3,700,000                                              
    March 2014 Letter Agreement [Member]                                                                                    
    Gain (Loss) on Extinguishment of Debt, Total                                                           (1,800,000)                        
    Debt Conversion, Original Debt, Amount                                     $ 3,400,000                                              
    August 2013 Convertible Notes [Member]                                                                                    
    Debt Instrument, Convertible, Conversion Price                                                                 $ 4.40 $ 5.2977                
    August 2013 Convertible Notes [Member] | Related Party Convertible Notes [Member]                                                                                    
    Debt, Changes in Fair Value, Gain (Loss)                                                                                  
    Convertible Promissory Notes, Period After Which Notes Will Be Due                                                     5 years                              
    Long-term Debt, Gross                                 21,711,000                     21,711,000                        
    Long-term Debt, Total                                 $ 22,608,000                     $ 22,608,000                        
    August 2013 Convertible Notes [Member] | Total and Temasek [Member]                                                                                    
    Debt Instrument, Face Amount                                                                                 $ 73,000,000  
    First Tranche [Member] | Related Party Convertible Notes [Member]                                                                                    
    Gain (Loss) on Extinguishment of Debt, Total                 $ (10,900,000)                                                                  
    Plant Manufacturing Production, Product Sales, Percentage                                                     5.00%                              
    Repayments of Long-term Debt, Total                 15,200,000                                                                  
    Second Tranche [Member] | Related Party Convertible Notes [Member]                                                                                    
    Debt Instrument, Convertible, Conversion Price                           $ 4.40                             $ 4.40                          
    Convertible Promissory Notes, Period After Which Notes Will Be Due                                                   60 years                                
    Debt Instrument, Convertible, Conversion Price, Interest Accrued                                                   10.00%                                
    Debt Instrument, Covenant Terms, Maximum Debt                           $ 200,000,000                             $ 200,000,000                          
    Debt Instrument, Covenant Terms, Maximum Debt, Percentage of Consolidated Assets                           50.00%                             50.00%                          
    Debt Instrument, Covenant Terms, Maximum Secured Debt                           $ 125,000,000                             $ 125,000,000                          
    Debt Instrument, Covenant Terms, Maximum Secured Debt, Percentage of Consolidated Assets                           30.00%                             30.00%                          
    Second Tranche [Member] | Subsequent Event [Member] | Related Party Convertible Notes [Member]                                                                                    
    Debt Instrument, Cash Waiver Fee Amount Payable                                                               $ 600,000                    
    Tranche Notes [Member] | Related Party Convertible Notes [Member]                                                                                    
    Debt Instrument, Convertible, Conversion Price                                   $ 5.2977                       $ 5.2977     $ 4.40                  
    Gain (Loss) on Extinguishment of Debt, Total               $ (6,500,000)                                                                    
    Repayments of Long-term Debt, Total               9,800,000                                                                    
    Related Party Convertible Notes [Member] | Temasek [Member]                                                                                    
    Debt Conversion, Original Debt, Amount                                               $ 71,000,000                                    
    Related Party Convertible Notes [Member] | Total [Member]                                                                                    
    Debt Conversion, Original Debt, Amount                                               70,000,000                                    
    Long-term Debt, Gross                                               21,800,000                                    
    Related Party 2014 144A Convertible Notes [Member] | Temasek [Member]                                                                                    
    Long-term Debt, Gross                                               10,000,000                                    
    Related Party 2014 144A Convertible Notes [Member] | Total [Member]                                                                                    
    Long-term Debt, Gross                                               9,700,000                                    
    The 2015 Exchange Agreement [Member]                                                                                    
    Debt Instrument, Covenant, Maximum Amount of Debt                                               $ 200,000,000                                    
    Debt Instrument, Covenant, Maximum Amount of Debt Percentage of Total Assets                                               50.00%                                    
    Debt Instrument, Covenant, Maximum Amount of Secured Debt                                               $ 125,000,000                                    
    Debt Instrument, Covenenant, Maximum Amount of Secured Debt to Total Assets                                               30.00%                                    
    The $5 Million Note [Member]                                                                                    
    Debt Instrument, Face Amount                                   $ 5,000,000                       $ 5,000,000                        
    Proceeds from Convertible Debt                                   5,000,000                                                
    Convertible Debt, Fair Value Disclosures                                   $ 0                       0                        
    Tranche I Notes [Member]                                                                                    
    Gain (Loss) on Extinguishment of Debt, Total                 $ 10,900,000                                                                  
    Debt Conversion, Converted Instrument, Shares Issued                 3,448,821                                                                  
    Long-term Debt, Total                 $ 15,200,000                                                                  
    Tranche II Notes [Member]                                                                                    
    Gain (Loss) on Extinguishment of Debt, Total               $ 6,500,000                                                                    
    Debt Conversion, Converted Instrument, Shares Issued               2,226,105                                                                    
    Long-term Debt, Total               $ 9,800,000                                                                    
    Total Purchase Agreement [Member] | Total [Member]                                                                                    
    Debt Instrument, Face Amount                                                                           $ 105,000,000        
    Loan and Security Agreement [Member] | Great American Capital Partners, LLC [Member]                                                                                    
    Debt Instrument, Face Amount                   $ 36,000,000                                                                
    Line of Credit Facility, Maximum Borrowing Capacity                   $ 35,000,000                                                                
    Loan Annual Amortization Percentage of Loan Accounts Outstanding                   2.50%                                                                
    Debt Instrument, Facility Charge, Percentage                           4.00%                             4.00%                          
    Debt Instrument, Origination Fee Amount                           $ 1,400,000                             $ 1,400,000                          
    Debt Instrument, Funded Amount and Other Closing Costs                           200,000                             200,000                          
    Debt Instrument, Agency Fee Amount Per Quarter                           25,000                             25,000                          
    Unamortized Debt Issuance Expense                           $ 1,600,000                             $ 1,600,000                          
    Loan and Security Agreement [Member] | Great American Capital Partners, LLC [Member] | Minimum [Member]                                                                                    
    Debt Instrument, Interest Rate, Stated Percentage                           8.25% 6.25%                           8.25%                          
    Loan and Security Agreement [Member] | Great American Capital Partners, LLC [Member] | Minimum [Member] | Prime Rate [Member]                                                                                    
    Debt Instrument, Basis Spread on Variable Rate                   4.00%       4.00% 4.00%                                                      
    Loan and Security Agreement [Member] | Great American Capital Partners, LLC [Member] | Maximum [Member]                                                                                    
    Debt Instrument, Interest Rate, Stated Percentage                           9.00% 8.25%                           9.00%                          
    Loan and Security Agreement [Member] | Great American Capital Partners, LLC [Member] | Maximum [Member] | Prime Rate [Member]                                                                                    
    Debt Instrument, Basis Spread on Variable Rate                   6.25%       4.75% 4.00%                                                      
    Loan and Security Agreement [Member] | Hercules Technology Growth Capital, Inc. (Hercules) [Member]                                                                                    
    Debt Instrument, Face Amount                                                                               $ 25,000,000    
    Line of Credit Facility, Maximum Borrowing Capacity                                                             $ 31,000,000                      
    Proceeds from Long-term Lines of Credit                                                             $ 16,000,000                      
    Loan and Security Agreement [Member] | Stegodon [Member]                                                                                    
    Repayments of Lines of Credit                                 $ 5,500,000                                                  
    Proceeds from (Repayments of) Lines of Credit, Total                                                       $ 5,500,000                            
    Debt Instrument, Interest Rate, Increase (Decrease)                               5.00%                                                    
    Secured Promissory Note In Connection With Termination of Ginkgo Collaboration Agreement [Member]                                                                                    
    Debt Instrument, Face Amount                                                                     $ 12,000,000              
    Debt Instrument, Interest Rate, Stated Percentage                                                                     10.50%              
    Debt Instrument, Fair Value Disclosure, Total                                                                     $ 7,000,000              
    Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net, Total                                                                     $ 5,000,000              
    Secured Promissory Note In Connection With Termination of Ginkgo Collaboration Agreement [Member] | License [Member]                                                                                    
    Interest Expense, Total                                                           $ 7,000,000                        
    Nikko Note [Member] | Nikko [Member]                                                                                    
    Debt Instrument, Face Amount                                           $ 3,900,000                                        
    Debt Instrument, Interest Rate, Stated Percentage                                           5.00%                                        
    Debt Instrument, Proceeds Used to Repay Liabilities                                           $ 3,500,000                                        
    Debt Instrument, Term                                           13 years                                        
    Debt Instrument, Percentage of Joint Venture Interests Owned By the Company Securing the Debt Instrument                                           10.00%                                        
    Debt Instrument, Additional Payments Required in Four Monthly Installments                                           $ 400,000                                        
    Debt Instrument, Additional Equal Monthly Installments, Amount                                           100,000                                        
    Aprinnova Notes [Member] | Unsecured Debt [Member] | Aprinnova JV [Member]                                                                                    
    Debt Instrument, Face Amount                                       $ 1,500,000                                            
    Debt Instrument, Periodic Payment, Total                                       $ 375,000                                            
    Second Aprinnova Loan [Member] | Nikko [Member]                                                                                    
    Debt Instrument, Face Amount                                           $ 1,500,000                                        
    Second Aprinnova Loan [Member] | Unsecured Debt [Member] | Aprinnova JV [Member] | Nikko [Member]                                                                                    
    Debt Instrument, Face Amount                                                                       $ 1,500,000            
    Debt Instrument, Interest Rate, Stated Percentage                                       2.75%                                            
    Guanfu Credit Agreement [Member] | Unsecured Debt [Member] | Guanfu Holding Co., Ltd [Member]                                                                                    
    Line of Credit Facility, Maximum Borrowing Capacity                                                                         $ 25,000,000          
    [1] Loss on extinguishment of related and unrelated party debt.
    [2] Correction to amortization of debt discounts, and interest expense in connection with partnership payments obligation.
    XML 68 R90.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 13 - Divestiture (Details Textual) - USD ($)
    1 Months Ended 12 Months Ended
    Dec. 28, 2017
    Nov. 30, 2018
    Jun. 30, 2018
    Dec. 31, 2018
    Dec. 31, 2017
    Disposal Group, Not Discontinued Operation, Gain (Loss) on Disposal $ 5,700,000     $ (1,778,000) $ 5,732,000
    Revenue from Contract with Customer, Including Assessed Tax       63,604,000 127,671,000
    Proceeds from Divestiture of Businesses       54,827,000
    DSM International B.V. [Member]          
    Disposal Group, Including Discontinued Operation, Consideration 17,800,000        
    Post-closing Working Capital Adjustment Payment Recorded as Loss on Divestiture       2,100,000  
    Revenue from Contract with Customer, Including Assessed Tax     $ 9,300,000    
    Contract with Customer, Liability, Total       34,700,000  
    DSM Credit Agreement [Member]          
    Line of Credit Facility, Maximum Borrowing Capacity 25,000,000       25,000,000
    Royalty [Member] | DSM International B.V. [Member]          
    Revenue from Contract with Customer, Including Assessed Tax 15,000,000        
    Line of Credit Facility, Maximum Borrowing Capacity         $ 25,000,000
    License [Member] | DSM International B.V. [Member]          
    Revenue from Contract with Customer, Including Assessed Tax 27,500,000     54,700,000  
    Performance Option and Transition Services Agreements [Member] | DSM International B.V. [Member]          
    Contract with Customer, Liability, Total       2,100,000  
    DSM [Member]          
    Disposal Group, Including Discontinued Operation, Consideration 17,800,000        
    DSM [Member] | License and Service [Member]          
    Revenue from Contract with Customer, Including Assessed Tax 27,500,000        
    DSM [Member] | Royalty [Member]          
    Revenue from Contract with Customer, Including Assessed Tax 15,000,000        
    Amyris Brasil [Member]          
    Divestiture of Business, Consideration Transferred 56,900,000        
    Disposal Group, Not Discontinued Operation, Gain (Loss) on Disposal 5,700,000        
    Proceeds from Divestiture of Businesses       $ 54,800,000  
    Amyris Brasil [Member] | DSM [Member]          
    Post-closing Working Capital Adjustment Payment Recorded as Loss on Divestiture   $ 1,800,000      
    Amyris Brasil [Member] | Disposal Group, Not Discontinued Operations [Member]          
    Disposal Group, Including Discontinued Operation, Consideration 33,000,000        
    Repayments of Debt $ 12,600,000        
    XML 69 R26.htm IDEA: XBRL DOCUMENT v3.19.3
    Significant Accounting Policies (Policies)
    12 Months Ended
    Dec. 31, 2018
    Accounting Policies [Abstract]  
    Liquidity [Policy Text Block]
    Going Concern
     
    The Company has incurred significant operating losses since its inception and expects to continue to incur losses and negative cash flows from operations for at least the next
    12
    months following the issuance of the financial statements. As of
    December 
    31,
    2018,
    the Company had negative working capital of
    $119.5
    million and an accumulated deficit of
    $1.5
    billion.
     
    As of
    December 
    31,
    2018,
    the Company's debt (including related party debt), net of deferred discount and issuance costs of
    $17.1
    million and a change in fair value of
    $2.1
    million, totaled
    $209.7
    million, of which
    $147.7
    million is classified as current. The Company's debt agreements contain various covenants, including certain restrictions on the Company's business that could cause the Company to be at risk of defaults, such as restrictions on additional indebtedness, material adverse effect and cross default clauses. A failure to comply with the covenants and other provisions of the Company’s debt instruments, including any failure to make a payment when required, would generally result in events of default under such instruments, which could permit acceleration a substantial portion of such indebtedness. If such indebtedness is accelerated, it would generally also constitute an event of default under the Company’s other outstanding indebtedness, permitting acceleration of a substantial portion of such other outstanding indebtedness. At
    December 31, 2018,
    the Company failed to meet certain covenants in connection with the GACP Term Loan Facility (see Note
    5,
    “Debt”), including those associated with minimum revenue and minimum liquidity requirements. In
    April 2019, (
    i) GACP provided a waiver to the Company for breaches of all covenant violations under the GACP loan and security agreement (LSA) occurring prior to, as of and after
    December 31, 2018
    through
    April 8, 2019,
    and (ii) GACP sold and assigned the loans under the LSA and all documents and assets related thereto to Foris Ventures, LLC (Foris). Subsequently, Foris provided a waiver to the Company for breaches of certain covenants under the LSA through
    June 30, 2020
    and amended the financial covenants under the LSA to provide more favorable compliance terms and conditions. See Note
    16,
    "Subsequent Events" for additional information.
     
    Cash and cash equivalents of
    $45.4
    million as of
    December 
    31,
    2018
    are
    not
    sufficient to fund expected future negative cash flows from operations and cash debt service obligations through
    September 
    30,
    2020.
    These factors raise substantial doubt about the Company’s ability to continue as a going concern within
    one
    year after the date that these financial statements are issued. The consolidated financial statements do
    not
    include any adjustments that might result from the outcome of this uncertainty. The Company's ability to continue as a going concern will depend, in large part, on its ability to achieve positive cash flows from operations during the
    12
    months from the date of this filing, and refinance or extend other existing debt maturities occurring later in
    2019,
    all of which are uncertain and outside the control of the Company. Further, the Company's operating plan for
    2019
    contemplates a significant reduction in its net operating cash outflows as compared to the year ended
    December 
    31,
    2018,
    resulting from (i) revenue growth from sales of existing and new products with positive gross margins, (ii) reduced production costs as a result of manufacturing and technical developments, and (iii) an increase in cash inflows from collaborations and grants. If the Company is unable to complete these actions, it expects to be unable to meet its operating cash flow needs and its obligations under its existing debt facilities. This could result in an acceleration of its obligation to repay all amounts outstanding under those facilities, and the Company
    may
    be forced to obtain additional equity or debt financing, which
    may
    not
    occur timely or on reasonable terms, if at all, and/or liquidate its assets. In such a scenario, the value received for assets in liquidation or dissolution could be significantly lower than the value reflected in these financial statements. The Company has in the past, including in
    July 2019,
    had certain of its debt instruments accelerated for failure to make a payment when due. While we have been able to cure these defaults to date to avoid additional cross-acceleration, we
    may
    not
    be able to cure such a default promptly in the future.
     
    On
    September 16, 2019,
    the Company failed to pay an aggregate of
    $63.6
    million of outstanding principal and accrued interest on the Second Exchange Note when due. The failure resulted in an event of default under the Second Exchange Note and also triggered cross-defaults under other debt instruments of the Company which permitted the holders of such indebtedness to accelerate the amounts owing under such instruments. The Company subsequently received waivers from substantially all holders of such other debt instruments to waive the right to accelerate. As a result, the indebtedness with respect to which the Company has obtained such waivers continues to be classified as long-term on the Company’s balance sheet.  The indebtedness reflected by the Second Exchange Note continues to be classified as a current liability on the Company’s balance sheet. In addition, as a result of the payment default, the conversion price of the Second Exchange Note is subject to adjustment in accordance with the terms of the Second Exchange Note.
     
    The Company does
    not
    currently have sufficient funds to repay the amounts outstanding under the Second Exchange Note. To date, negotiations with the holder of the Second Exchange Note have
    not
    been successful, and there can be
    no
    assurance that a favorable outcome for the Company will be reached. The Company has executed a term sheet with an existing investor for a term loan, the proceeds of which would be used to repay a portion of the Second Exchange Note. However, there can be
    no
    assurance that the Company will be able to obtain such financing on its expected timeline, or on acceptable terms, if at all. Even if the Company does obtain such financing, it will
    not
    have sufficient funds to repay the Second Exchange Note in full without obtaining additional financing, which the Company is attempting to source. The consolidated financial statements do
    not
    include any adjustments that might result from the outcome of this uncertainty.
    Basis of Accounting, Policy [Policy Text Block]
    Basis of Consolidation
     
    The accompanying consolidated financial statements have been prepared in accordance with the accounting principles generally accepted in the United States (U.S. GAAP). The consolidated financial statements include the accounts of Amyris, Inc. and its wholly-owned and partially-owned subsidiaries in which the Company has a controlling interest after elimination of all significant intercompany accounts and transactions.
     
    Investments and joint venture arrangements are assessed to determine whether the terms provide economic or other control over the entity requiring consolidation of the entity. Entities controlled by means other than a majority voting interest are referred to as variable-interest entities (VIEs) and are consolidated when Amyris has both the power to direct the activities of the VIE that most significantly impact its economic performance and the obligation to absorb losses or the right to receive benefits that could potentially be significant to the entity. For any investment or joint venture in which (i) the Company does
    not
    have a majority ownership interest, (ii) the Company possesses the ability to exert significant influence and (iii) the entity is
    not
    a VIE for which the Company is considered the primary beneficiary, the Company accounts for the investment or joint venture using the equity method. Following the adoption of ASU
    2016
    -
    01
    on
    January 1, 2018
    described in more detail below (which was applicable to the Company on a prospective basis), equity investments in which the Company does
    not
    exert significant influence and that do
    not
    have readily determinable fair values are measured at cost, adjusted for changes from observable market transactions, less impairment (“adjusted cost basis”). The Company evaluates its investments for impairment by considering a variety of factors, including the earnings capacity of the related investments. Fair value measurements for the Company’s equity investments are classified within Level
    3
    of the fair value hierarchy based on the nature of the fair value inputs. Realized and unrealized gains or losses are recognized in other income or expense.
    Sale of Subsidiary and Entry Into Commercial Agreements, Policy [Policy Text Block]
    Sale of Subsidiary and Entry into Commercial Agreements
     
    On
    December 28, 2017,
    the Company completed the sale of all of the capital stock of its subsidiary Amyris Brasil, a wholly-owned subsidiary, to DSM Produtos Nutricionais Brasil S.A (DSM), a related party. Amyris Brasil owned and operated the Company’s production facility in Brotas, Brazil. The transaction resulted in a pretax gain of
    $5.7
    million from continuing operations in
    2017,
    which was further adjusted by a
    $1.8
    million loss in
    2018
    related to the final working capital adjustments between the Company and DSM. The transaction did
    not
    result in presenting Amyris Brasil as a discontinued operation in the consolidated financial statements, as the sale did
    not
    represent a strategic shift that will have a major effect on the Company’s operations and financial results due to the Company’s continuing commercial presence and reinvestment in a new production facility under construction in Brazil and its continuing Brazilian operation through Amyris Biotecnologia do Brasil Ltda. (formerly SMA Indústria Química Ltda.). The Company and DSM also entered into a series of commercial agreements and a credit agreement concurrently with the sale of Amyris Brasil. See Note
    10,
    “Revenue Recognition”, Note
    11,
    “Related Party Transactions”, Note
    13,
    “Divestiture” and Note
    16,
    “Subsequent Events” for further information.
    Use of Estimates, Policy [Policy Text Block]
    Use of Estimates and Judgements
     
    The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates, judgements and assumptions that affect the reported amounts of assets and liabilities, disclosures of contingent assets and liabilities at the date of the financial statements, and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates, and such differences
    may
    be material to the consolidated financial statements.
    Cash and Cash Equivalents, Policy [Policy Text Block]
    Cash and Cash Equivalents
     
    The Company considers all highly liquid investments purchased with an original or remaining maturity of
    three
    months or less at the date of purchase to be cash equivalents. Cash and cash equivalents are maintained with various financial institutions.
    Inventory, Policy [Policy Text Block]
    Inventories
     
    Inventories, which consist of farnesene-derived products, flavors and fragrances ingredients and clean beauty products, are stated at the lower of actual cost or net realizable value and are categorized as finished goods, work in process or raw material inventories. The Company evaluates the recoverability of its inventories based on assumptions about expected demand and net realizable value. If the Company determines that the cost of inventories exceeds their estimated net realizable value, the Company records a write-down equal to the difference between the cost of inventories and the estimated net realizable value. If actual net realizable values are less favorable than those projected by management, additional inventory write-downs
    may
    be required that could negatively impact the Company's operating results. If actual net realizable values are more favorable, the Company
    may
    have favorable operating results when products that have been previously written down are sold in the normal course of business. The Company also evaluates the terms of its agreements with its suppliers and establishes accruals for estimated losses on adverse purchase commitments as necessary, applying the same lower of cost or net realizable value approach that is used to value inventory. Cost is computed on a weighted-average basis.
    Property, Plant and Equipment, Policy [Policy Text Block]
    Property, Plant and Equipment, Net
     
    Property, plant and equipment are recorded at cost. Depreciation and amortization are computed straight-line based on the estimated useful lives of the related assets, ranging from
    3
    to
    15
    years for machinery, equipment and fixtures, and
    15
    years for buildings. Leasehold improvements are amortized over their estimated useful lives or the period of the related lease, whichever is shorter.
     
    The Company expenses costs for maintenance and repairs and capitalizes major replacements, renewals and betterments. For assets retired or otherwise disposed, both cost and accumulated depreciation are eliminated from the asset and accumulated depreciation accounts, and gains or losses related to the disposal are recorded in the statement of operations for the period.
    Impairment or Disposal of Long-Lived Assets, Including Intangible Assets, Policy [Policy Text Block]
    Impairment
     
    Long-lived assets that are held and used by the Company are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount of such assets
    may
    not
    be recoverable. Determination of recoverability of long-lived assets is based on an estimate of the undiscounted future cash flows resulting from the use of the asset and its eventual disposition. Measurement of an impairment loss for long-lived assets that management expects to hold and use is based on the difference between the fair value of the asset and its carrying value. Long-lived assets to be disposed of are reported at the lower of carrying amount or fair value less costs to sell.
    Recoverable Taxes from Brazilian Government Entities [Policy Text Block]
    Recoverable Taxes from Brazilian Government Entities
     
    Recoverable taxes from Brazilian government entities represent value-added taxes paid on purchases in Brazil, which are reclaimable from the Brazilian tax authorities, net of reserves for amounts estimated
    not
    to be recoverable.
    Fair Value Measurement, Policy [Policy Text Block]
    Fair Value Measurements
     
    The carrying amounts of certain financial instruments, such as cash equivalents, short-term investments, accounts receivable, accounts payable and accrued liabilities, approximate fair value due to their relatively short maturities.
     
    The Company measures the following financial assets and liabilities at fair value:
    Freestanding and bifurcated derivatives in connection with certain debt and equity financings; and
    6%
    Convertible Notes Due
    2021
    (see Note
    4,
    "Fair Value Measurement", Note
    5,
    "Debt" and Note
    16,
    “Subsequent Events”), for which the Company has elected fair value accounting
     
    Fair value is based on the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants. Where available, fair value is based on or derived from observable market prices or other observable inputs. Where observable prices or inputs are
    not
    available, valuation techniques are applied. These valuation techniques involve some level of management estimation and judgement, the degree of which is dependent on the price transparency for the instruments or market and the instruments’ complexity.
     
    Changes to the inputs used in these valuation models have a significant impact on the estimated fair value of the
    6%
    Convertible Notes Due
    2021
    and the Company's embedded and freestanding derivatives. For example, a decrease (increase) in the estimated credit spread for the Company results in an increase (decrease) in estimated fair value. Conversely, a decrease (increase) in the stock price results in a decrease (increase) in estimated fair value.
     
    The changes during
    2018
    and
    2017
    in the fair values of the bifurcated compound embedded derivatives are primarily related to the change in price of the Company's common stock and are reflected in the consolidated statements of operations as “Gain (loss) from change in fair value of derivative instruments”.
     
    For debt instruments for which the Company has
    not
    elected fair value accounting, fair value is based on the present value of expected future cash flows and assumptions about the then-current market interest rates as of the reporting period and the creditworthiness of the Company. Most of the Company's debt is carried on the consolidated balance sheet on a historical cost basis net of unamortized discounts and premiums, because the Company has
    not
    elected the fair value option of accounting. However, for the
    6%
    Notes Due
    2021,
    the Company elected fair value accounting, so that balances reported for that debt instrument represent fair value as of each balance sheet date; see Note
    4,
    "Fair Value Measurement", for additional information. Changes in fair value of the
    6%
    Convertible Notes Due
    2021
    are reflected in the consolidated statements of operations as “Gain (loss) from change in fair value of debt”.
     
    For all debt instruments, including any for which the Company has elected fair value accounting, the Company classifies interest that has been accrued during each period as Interest expense on the consolidated statements of operations.
    Derivatives, Policy [Policy Text Block]
    Derivatives
     
    Embedded derivatives that are required to be bifurcated from the underlying debt instrument (i.e., host) are accounted for and valued as separate financial instruments. The Company has evaluated the terms and features of its convertible notes payable and convertible preferred stock and identified compound embedded derivatives requiring bifurcation and accounting at fair value, using the valuation techniques mentioned in the
    Fair Value Measurements
    section of this Note, because the economic and contractual characteristics of the embedded derivatives met the criteria for bifurcation and separate accounting due to the instruments containing conversion options, certain “make-whole interest” provisions, down-round conversion price adjustment provisions and/or conversion rate adjustments.
     
    Cash warrants and anti-dilution warrants issued in conjunction with the convertible debt and equity financings are freestanding financial instruments which are also classified as derivative liabilities.
     
    Noncontrolling Interest [Policy Text Block]
    Noncontrolling Interest
     
    Noncontrolling interests represent the portion of net income (loss), net assets and comprehensive income (loss) that is
    not
    allocable to the Company, in situations where the Company consolidates its equity investment in a joint venture for which there are other owners. The amount of noncontrolling interest is comprised of the amount of such interests at the date of the Company's original acquisition of an equity interest in a joint venture, plus the other shareholders' share of changes in equity since the date the Company made an investment in the joint venture.
    Concentration Risk, Credit Risk, Policy [Policy Text Block]
    Concentration of Credit Risk
     
    Financial instruments that potentially subject the Company to a concentration of credit risk consist primarily of cash and cash equivalents, short-term investments and accounts receivable. The Company places its cash equivalents and investments (primarily certificates of deposits) with high credit quality financial institutions and, by policy, limits the amount of credit exposure with any
    one
    financial institution. Deposits held with banks
    may
    exceed the amount of insurance provided on such deposits. The Company has
    not
    experienced any losses on its deposits of cash and cash equivalents and short-term investments.
     
    The Company performs ongoing credit evaluation of its customers, does
    not
    require collateral, and maintains allowances for potential credit losses on customer accounts when deemed necessary.
     
    Customers representing
    10%
    or greater of accounts receivable were as follows:
     
    As of December 31,   2018   2017
    Customer B    
    24
    %    
    10
    %
    Customer C    
    19
    %    
    15
    %
    Customer G    
    11
    %    
    **
    Customer A (related party)    
    **
         
    38
    %
    ______________
    ** Less than
    10%
     
    Customers representing
    10%
    or greater of revenue were as follows:
     
    Years Ended December 31,   2018   2017
            (As Restated, Note 2)
    Customer A (related party)    
    17
    %    
    46
    %
    Customer B    
    18
    %    
    13
    %
    Customer C    
    13
    %    
    **
     
    Customer D    
    13
    %    
    **
     
    Customer E    
    **
         
    11
    %
    Customer F     **       **  
     
    ______________
    ** Less than
    10%
    Revenue from Contract with Customer [Policy Text Block]
    Revenue Recognition
     
    Year ended
    December 31, 2017
     
    For the year ended
    December 31, 2017,
    the Company recognized revenue from the sale of renewable products, licenses of and royalties from intellectual property, and grants and collaborative research and development services. Revenue was recognized when all of the following criteria were met: persuasive evidence of an arrangement existed, delivery has occurred or services have been rendered, the fee was fixed or determinable, and collectability was reasonably assured. If sales arrangements contained multiple elements, the Company evaluated whether the components of each arrangement represent separate units of accounting.
     
    Renewable Product Sales
     
    The Company’s renewable product sales do
    not
    include rights of return, except for sales of Biossance products. Returns are only accepted if the product does
    not
    meet product specifications and such nonconformity is communicated to the Company within a set number of days of delivery. The Company offers a
    two
    -year standard warranty provision for squalane products, if the products do
    not
    meet Company-established criteria as set forth in the Company’s trade terms. The Company bases its return reserve on a historical rate of return for the Company’s squalane products. Revenues are recognized, net of discounts and allowances, once passage of title and risk of loss has occurred and contractually specified acceptance criteria have been met, provided all other revenue recognition criteria have also been met.
     
    Licenses and Royalties
     
    License fees for intellectual property transferred to other parties, representing non-refundable payments received at the time of signature of license agreements, are recognized as revenue upon signature of the license agreements when the Company has
    no
    significant future performance obligations and collectability of the fees is assured. Upfront payments received at the beginning of licensing agreements with future service obligations are deferred and recognized as revenue on a systematic basis over the period during which the related services are rendered and all obligations are performed.
     
    Royalties from intellectual property licenses that allow Amyris's customers to use the Company’s intellectual property to produce and sell their products in which the Company shares in the profits are recognized in the period the royalty report is received.
     
    Grants and Collaborative Research and Development Services
     
    Revenues from collaborative research and development services are recognized as the services are performed consistent with the performance requirements of the contract. In cases where the planned levels of research and development services fluctuate over the research term, the Company recognizes revenues using the proportional performance method based upon actual efforts to date relative to the amount of expected effort to be incurred by us. When up-front payments are received and the planned levels of research and development services do
    not
    fluctuate over the research term, revenues are recorded on a ratable basis over the arrangement term, up to the amount of cash received. When up-front payments are received and the planned levels of research and development services fluctuate over the research term, revenues are recorded using the proportional performance method, up to the amount of cash received. Where arrangements include milestones that are determined to be substantive and at risk at the inception of the arrangement, revenues are recognized upon achievement of the milestone and is limited to those amounts whereby collectability is reasonably assured.
     
    Grants are agreements that generally provide cost reimbursement for certain types of expenditures in return for research and development activities over a contractually defined period. Revenues from grants are recognized in the period during which the related costs are incurred, provided that the conditions under which the grants were provided have been met and only perfunctory obligations are outstanding.
     
    Year ended
    December 31, 2018
     
    In accordance with a new revenue recognition standard that the Company adopted
    January 1, 2018,
    the Company recognizes revenue from the sale of renewable products, licenses of and royalties from intellectual property, and grants and collaborative research and development services. Revenue is measured based on the consideration specified in a contract with a customer, and transaction price is allocated utilizing stand-alone selling price. Revenue is recognized when, or as, the Company satisfies a performance obligation by transferring control over a product or service to a customer. The Company generally does
    not
    incur costs to obtain new contracts. The costs to fulfill a contract are expensed as incurred.
     
    The Company accounts for a contract when it has approval and commitment to perform from both parties, the rights of the parties are identified, payment terms are established, the contract has commercial substance and collectability of the consideration is probable. Changes to contracts are assessed for whether they represent a modification or should be accounted for as a new contract. The Company considers the following indicators, among others, when determining if it is acting as a principal in the transaction and recording revenue on a gross basis: (i) the Company is primarily responsible for fulfilling the promise to provide the specified goods or service, (ii) the Company has inventory risk before the specified good or service has been transferred to a customer or after transfer of control to the customer and (iii) the Company has discretion in establishing the price for the specified good or service. If a transaction does
    not
    meet the Company's indicators of being a principal in the transaction, then the Company is acting as an agent in the transaction and the associated revenues are recognized on a net basis.
     
    The Company’s significant contracts and contractual terms with its customers are presented in Note
    10,
    "Revenue Recognition".
     
    The Company recognizes revenue when control has passed to the customer. The following indicators are evaluated in determining when control has passed to the customer: (i) the Company has a right to receive payment for the product or service, (ii) the customer has legal title to the product, (iii) the Company has transferred physical possession of the product to the customer, (iv) the customer has the significant risk and rewards of ownership of the product and (v) the customer has accepted the product. For most of the Company's renewable products customers, supply agreements between the Company and each customer indicate when transfer of title occurs.
     
    In some cases, the Company
    may
    make a payment to a customer. When that occurs, the Company evaluates whether the payment is for a distinct good or service receivable from the customer. If the fair value of the goods or services receivable is greater than or equal to the amount paid to the customer, then the entire payment is treated as a purchase. If, on the other hand, the fair value of goods or services is less than the amount paid, then the difference is treated as a reduction in transaction price of the Company's sales to the customer.
     
    Performance Obligations
     
    A performance obligation is a promise in a contract to transfer a distinct good or service to the customer. A contract’s transaction price is allocated to each distinct performance obligation and recognized as revenue when, or as, the performance obligation is satisfied. The Company's contracts
    may
    contain multiple performance obligations if a promise to transfer the individual goods or services is separately identifiable from other promises in the contracts and, therefore, is considered distinct. For contracts with multiple performance obligations, the Company determines the standalone selling price of each performance obligation and allocates the total transaction price using the relative selling price basis.
     
    The following is a description of the principal goods and services from which the Company generates revenue.
     
    Renewable Product Sales
     
    Revenues from renewable product sales are recognized as a distinct performance obligation on a gross basis as the Company is acting as a principal in these transactions, with the selling price to the customer recorded net of discounts and allowances. Revenues are recognized at a point in time when control has passed to the customer, which typically is upon the renewable products leaving the Company’s facilities with the
    first
    transportation carrier. The Company, on occasion,
    may
    recognize revenue under a bill and hold arrangement, whereby the customer requests and agrees to purchase product but requests delivery at a later date. Under these arrangements, control transfers to the customer when the product is ready for delivery, which occurs when the product is identified separately as belonging to the customer, the product is ready for shipment to the customer in its current form, and the Company does
    not
    have the ability to direct the product to a different customer. It is at this point that the Company has the right to receive payment, the customer obtains legal title, and the customer has the significant risks and rewards of ownership. The Company’s renewable product sales do
    not
    include rights of return, except for Biossance products, for which the Company estimates sales returns subsequent to sale and reduces revenue accordingly. For renewable products other than Biossance, returns are accepted only if the product does
    not
    meet product specifications and such nonconformity is communicated to the Company within a set number of days of delivery. The Company offers a
    two
    -year assurance-type warranty to replace squalane products that do
    not
    meet Company-established criteria as set forth in the Company’s trade terms. An estimate of the cost to replace the squalane products sold is made based on a historical rate of experience and recognized as a liability and related expense when the renewable product sale is consummated.
     
    Licenses and Royalties
     
    Licensing of Intellectual Property:
    When the Company’s intellectual property licenses are determined to be distinct from the other performance obligations identified in the arrangement, revenue is recognized from non-refundable, up-front fees allocated to the license at a point in time when the license is transferred to the licensee and the licensee is able to use and benefit from the license. For intellectual property licenses that are combined with other promises, the Company utilizes judgment to assess the nature of the combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purposes of recognizing revenue from non-refundable, up-front-fees. The Company evaluates the measure of progress each reporting period and, if necessary, adjusts the measure of performance and related revenue recognized.
     
    Royalties from Licensing of Intellectual Property:
    The Company earns royalties from the licensing of its intellectual property whereby the licensee uses the intellectual property to produce and sell its products to its customers and the Company shares in the profits.
     
    When the Company’s intellectual property license is the only performance obligation, or it is the predominant performance obligation in arrangements with multiple performance obligations, the Company applies the sales-based royalty exception which requires the Company to estimate the revenue that is recognized at a point in time when the licensee’s product sales occur. Estimates of sales-based royalty revenues are made using the most likely outcome method, which is the single amount in a range of possible amounts, using the best evidence available at the time, derived from the licensee’s historical sales volumes and sales prices of its products and recent commodity market pricing data and trends. Estimates are adjusted to actual or as new information becomes available.
     
    When the Company’s intellectual property license is
    not
    the predominant performance obligation in arrangements with multiple performance obligations, the royalty represents variable consideration and is allocated to the transaction price of the predominant performance obligation which generally is the supply of renewable products to the Company's customers. Revenue is estimated and recognized at a point in time when the renewable products are delivered to the customer. Estimates of the amount of variable consideration to include in the transaction price are made using the expected value method, which is the sum of probability-weighted amounts in a range of possible amounts determined based on the cost to produce the renewable product plus a reasonable margin for the profit share. The Company only includes an amount of variable consideration in the transaction price to the extent it is probable that a significant reversal in the cumulative revenue recognized will
    not
    occur when the uncertainty associated with the variable consideration is subsequently resolved. Also, the transaction price is reduced for estimates of customer incentive payments payable by the Company for certain customer contracts.
     
    Grants and Collaborative Research and Development Services
     
    Collaborative Research and Development Services:
    The Company earns revenues from collaboration agreements with customers to perform research and development services to develop new molecules using the Company’s technology and to scale production of the molecules for commercialization and use in the collaborator’s products. The collaboration agreements generally include providing the Company's collaboration partners with research and development services and with licenses to the Company’s intellectual property to use the technology underlying the development of the molecules and to sell its products that incorporate the technology. The terms of the Company's collaboration agreements typically include
    one
    or more of the following: advance payments for the research and development services that will be performed, nonrefundable upfront license payments, milestone payments to be received upon the achievement of the milestone events defined in the agreements, and royalty payments upon the commercialization of the molecules in which the Company shares in the customer’s profits.
     
    Collaboration agreements are evaluated at inception to determine whether the intellectual property licenses represent distinct performance obligations separate from the research and development services. If the licenses are determined to be distinct, the non-refundable upfront license fee is recognized as revenue at a point in time when the license is transferred to the licensee and the licensee is able to use and benefit from the license while the research and development service fees are recognized over time as the performance obligations are satisfied. The research and development service fees represent variable consideration. Estimates of the amount of variable consideration to include in the transaction price are made using the expected value method, which is the sum of probability-weighted amounts in a range of possible amounts. The Company only includes an amount of variable consideration in the transaction price to the extent it is probable that a significant reversal in the cumulative revenue recognized will
    not
    occur when the uncertainty associated with the variable consideration is subsequently resolved. Revenue is recognized over time using either an input-based measure of labor hours expended or a time-based measure of progress towards the satisfaction of the performance obligations. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized.
     
    Collaboration agreements that include milestone payments are evaluated at inception to determine whether the milestone events are considered probable of achievement, and estimates are made of the amount of the milestone payments to include in the transaction price using the most likely amount method which is the single amount in a range of possible amounts. If it is probable that a significant revenue reversal will
    not
    occur, the estimated milestone payment amount is included in the transaction price. Each reporting period, the Company re-evaluates the probability of achievement of the milestone events and any related constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative basis, which would affect collaboration revenues in the period of adjustment. Generally, revenue is recognized using an input-based measure of progress towards the satisfaction of the performance obligations which can be labor hours expended or time-based in proportion to the estimated total project effort or total projected time to complete. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized. Certain performance obligations are associated with milestones agreed between the Company and its customer. Revenue generated from the performance of services in accordance with these milestones is recognized upon confirmation from the customer that the milestone has been achieved. In these cases, amounts recognized are constrained to the amount of consideration received upon achievement of the milestone. 
     
    The Company generally invoices its collaboration partners on a monthly or quarterly basis, or upon the completion of the effort or achievement of a milestone, based on the terms of each agreement. Deferred revenue arises from amounts received in advance of performing the research and development activities and is recognized as revenue in future periods as the performance obligations are satisfied.
     
    Grants:
    The Company earns revenues from grants with government agencies to, among other things, provide research and development services to develop molecules using the Company’s technology, and create research and development tools to improve the timeline and predictability for scaling molecules from proof of concept to market by reducing time and costs. Grants typically consist of research and development milestone payments to be received upon the achievement of the milestone events defined in the agreements.
     
    The milestone payments are evaluated at inception to determine whether the milestone events are considered probable of achievement and estimates are made of the amount of the milestone payments to include in the transaction price using the most likely amount method which is the single amount in a range of possible amounts. If it is probable that a significant revenue reversal will
    not
    occur, the estimated milestone payment amount is included in the transaction price. Each reporting period, the Company re-evaluates the probability of achievement of the milestone events and any related constraint and, if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative basis, which would affect grant revenues in the period of adjustment. Revenue is recognized over time using a time-based measure of progress towards the satisfaction of the performance obligations. The measure of progress is evaluated each reporting period and, if necessary, adjustments are made to the measure of progress and the related revenue recognized.
     
    Cost of Goods and Service [Policy Text Block]
    Cost of Products Sold
     
    Cost of products sold includes the production costs of renewable products, which include the cost of raw materials, in-house manufacturing labor and overhead, amounts paid to contract manufacturers, including amortization of tolling fees, and period costs including inventory write-downs resulting from applying lower of cost or net realizable value inventory adjustments. Cost of products sold also includes certain costs related to the scale-up of production. Shipping and handling costs charged to customers are recorded as revenues. Outbound shipping costs incurred are included in cost of products sold. Such charges were
    not
    material for any of the periods presented.
     
    The Company recognizes deferred cost of products sold as an asset on the balance sheet when a cost is incurred in connection with a revenue performance obligation that will
    not
    be fulfilled until a future period.
    Research and Development Expense, Policy [Policy Text Block]
    Research and Development
     
    Research and development costs are expensed as incurred and include costs associated with research performed pursuant to collaborative agreements and government grants, including internal research. Research and development costs consist of direct and indirect internal costs related to specific projects, as well as fees paid to others that conduct certain research activities on the Company’s behalf.
    Debt, Policy [Policy Text Block]
    Debt Extinguishment
     
    The Company accounts for the income or loss from extinguishment of debt in accordance with ASC
    470,
    Debt,
    which indicates that for all extinguishment of debt, the difference between the reacquisition consideration and the net carrying amount of the debt being extinguished should be recognized as gain or loss when the debt is extinguished. Losses from debt extinguishment are shown in the consolidated statements of operations under "Other income (expense)" as "Loss upon extinguishment of debt".
    Compensation Related Costs, Policy [Policy Text Block]
    Stock-based Compensation
     
    The Company accounts for stock-based employee compensation plans under the fair value recognition and measurement provisions of U.S. GAAP. Those provisions require all stock-based payments to employees, including grants of stock options and restricted stock units (RSUs), to be measured using the grant-date fair value of each award. The Company recognizes stock-based compensation expense net of expected forfeitures over each award's requisite service period, which is generally the vesting term. Expected forfeiture rates are estimated based on the Company's historical experience. Stock-based compensation plans are described more fully in Note
    12,
    "Stock-based Compensation".
    Income Tax, Policy [Policy Text Block]
    Income Taxes
     
    The Company is subject to income taxes in the United States and foreign jurisdictions and uses estimates to determine its provisions for income taxes. The Company uses the asset and liability method of accounting for income taxes, whereby deferred tax asset or liability account balances are calculated at the balance sheet date using current tax laws and rates in effect for the year in which the differences are expected to affect taxable income.
     
    Recognition of deferred tax assets is appropriate when realization of such assets is more likely than
    not.
    The Company recognizes a valuation allowance against its net deferred tax assets unless it is more likely than
    not
    that such deferred tax assets will be realized. This assessment requires judgement as to the likelihood and amounts of future taxable income by tax jurisdiction.
     
    The Company applies the provisions of Financial Accounting Standards Board (FASB) guidance on accounting for uncertainty in income taxes. The Company assesses all material positions taken in any income tax return, including all significant uncertain positions, in all tax years that are still subject to assessment or challenge by relevant taxing authorities. Assessing an uncertain tax position begins with the initial determination of the position’s sustainability, and the tax benefit to be recognized is measured at the largest amount of benefit that is greater than
    50
     percent likely of being realized upon ultimate settlement. As of each balance sheet date, unresolved uncertain tax positions must be reassessed, and the Company will determine whether (i) the factors underlying the sustainability assertion have changed and (ii) the amount of the recognized tax benefit is still appropriate. The recognition and measurement of tax benefits requires significant judgement, and such judgements
    may
    change as new information becomes available.
     
    Foreign Currency Transactions and Translations Policy [Policy Text Block]
    Foreign Currency Translation
     
    The assets and liabilities of foreign subsidiaries, where the local currency is the functional currency, are translated from their respective functional currencies into U.S. dollars at the rates in effect at each balance sheet date, and revenue and expense amounts are translated at average rates during each period, with resulting foreign currency translation adjustments recorded in other comprehensive loss, net of tax, in the consolidated statements of stockholders’ deficit. As of 
    December 
    31,
    2018
     and 
    2017,
    cumulative translation adjustment, net of tax, were
    $43.3
    million and 
    $42.2
    million, respectively.
     
    Where the U.S. dollar is the functional currency, remeasurement adjustments are recorded in other income (expense), net in the accompanying consolidated statements of operations. Net losses resulting from foreign exchange transactions were 
    $1.6
    million and 
    $0.4
    million for the years ended 
    December 
    31,
    2018
    and
    2017,
    respectively and are recorded in other income (expense), net in the consolidated statements of operations.
    New Accounting Pronouncements, Policy [Policy Text Block]
    New Accounting Standards or Updates Recently Adopted
     
    During the year ended
    December 
    31,
    2018
    the Company adopted the following Accounting Standards Updates (ASUs):
     
    Revenue Recognition
    The Company adopted ASC
    606,
    Revenue from Contracts with Customers
    , with a date of initial application of
    January 1, 2018.
    As a result, the Company has changed its accounting policy for revenue recognition as detailed above in “Significant Accounting Policies”. The Company applied ASC
    606
    using the modified retrospective approach by recognizing the cumulative effect of initially applying ASC
    606
    to all contracts
    not
    completed as of the date of adoption as an adjustment to the opening balance of accumulated deficit at
    January 1, 2018.
    Therefore, the comparative information has
    not
    been adjusted and continues to be reported under the legacy revenue recognition guidance of ASC
    605,
    "Revenue Recognition".
     
    The Company applied ASC
    606
    using a practical expedient for contracts that were modified before the application date, which allowed the Company to determine an aggregate effect of all modifications that occurred before
    January 1, 2018,
    when determining the satisfied and unsatisfied performance obligations, the transaction price, and allocating that transaction price to the performance obligations instead of retrospectively restating the contracts for such contract modifications.
     
    The cumulative effect of initially applying ASC
    606
    resulted in an increase to accumulated deficit at
    January 1, 2018
    of approximately
    $0.8
    million. The most significant change in accounting policy is the Company is now required to estimate royalty revenues from licenses of the Company’s intellectual property and recognize estimated royalty revenues at a point in time when the Company sells its renewable products to its customers (if the sales-based royalty exception does
    not
    apply) or when the licensee sells its products to its customer (if the sales-based royalty exception does apply).
     
    The following table presents the amounts by which revenue is affected in the current reporting period by the application of ASC
    606
    as compared with the legacy guidance that was in effect before the accounting change.
     
        Year Ended December 31, 2018
    (In thousands)   As Reported   Adjustments   Amounts Without the Adoption of ASC 606
    Renewable products   $
    33,598
        $
        $
    33,598
     
    Licenses and royalties    
    7,658
         
    5,094
         
    12,752
     
    Grants and collaborations    
    22,348
         
    (5,786
    )    
    16,562
     
    Total revenue from all customers   $
    63,604
        $
    (692
    )   $
    62,912
     
     
    Financial Instruments
    In
    January 2016,
    the Financial Accounting Standards Board (FASB) issued ASU
    2016
    -
    01,
     
    Financial Instruments-Overall (Subtopic
    825
    -
    10
    ): Recognition and Measurement of Financial Assets and Financial Liabilities
    , which changes the accounting for equity investments, financial liabilities under the fair value option, and the presentation and disclosure requirements for financial instruments. The Company adopted ASU
    2016
    -
    01
    on
    January 1, 2018.
    Adoption of this ASU did
    not
     impact the Company's consolidated financial position, results of operations or cash flows.
     
    Classification of Cash Flow Elements
    In
    August 2016,
    the FASB issued ASU
    2016
    -
    15,
     
    Statement of Cash Flows (Topic
    230
    ): Classification of Certain Cash Receipts and Cash Payments,
     which affects the classification of certain cash receipts and cash payments on the statement of cash flows. ASU
    2016
    -
    15
    results in a change in cash flow classification of debt prepayment or extinguishment costs. ASU
    2016
    -
    15
    became effective
    January 1, 2018
    on a retrospective basis. Adoption of this ASU did
    not
     impact the Company's consolidated financial position, results of operations or cash flows.
     
    Income Taxes Related to Intra-entity Asset Transfers
    In
    October 2016,
    FASB issued ASU
    2016
    -
    16,
    Intra-Entity Transfers of Assets Other Than Inventory
    on simplifying the accounting for income taxes related to intra-entity asset transfers. The new guidance allows an entity to recognize the tax expense from the sale of an asset in the seller’s tax jurisdiction when the transfers occurs, even though the pre-tax effects of that transaction are eliminated in consolidation. ASU
    2016
    -
    16
    became effective
    January 1, 2018,
    which the Company adopted on a modified retrospective basis.
     
    Restricted Cash in Statement of Cash Flows
    In
    November 2016,
    the FASB issued ASU
    2016
    -
    18,
     
    Statement of Cash Flows (Topic
    230
    ): Restricted Cash,
     which requires that a statement of cash flows explain the change during the period in the total of cash, cash equivalents, and amounts generally described as restricted cash or restricted cash equivalents. Therefore, amounts generally described as restricted cash and restricted cash equivalents should be included with cash and cash equivalents when reconciling the beginning-of-period and end-of-period total amounts shown on the statement of cash flows. The accounting standard update became effective
    January 1, 2018
    using a retrospective transition method for each period presented. Upon adoption, ASU
    2016
    -
    18
    resulted in a change in the presentation of restricted cash in the statement of cash flows for current and prior periods presented.
     
    Derecognition of Nonfinancial Assets
    In
    February 2017,
    the FASB issued ASU
    2017
    -
    05,
     
    Other Income—Gains and Losses from the Derecognition of Nonfinancial Assets (Subtopic
    610
    -
    20
    ): Clarifying the Scope of Asset Derecognition Guidance and Accounting for Partial Sales of Nonfinancial Assets
    , which requires entities to apply certain recognition and measurement principles in ASC
    606
    when they derecognize nonfinancial assets, and in substance, nonfinancial assets, and the counterparty is
    not
    a customer. The guidance applies to: (
    1
    ) contracts to transfer to a noncustomer a nonfinancial asset or group of nonfinancial assets, or an ownership interest in a consolidated subsidiary that does
    not
    meet the definition of a business and is
    not
    a
    not
    -for-profit activity; and (
    2
    ) contributions of nonfinancial assets that are
    not
    a business to a joint venture or other noncontrolled investee. The accounting standard update became effective
    January 1, 2018
    on a modified retrospective basis. Adoption of this ASU did
    not
     impact the Company's consolidated financial position, results of operations or cash flows.
     
    Income Taxes
    In
    March 2018,
    FASB issued ASU
    2018
    -
    05,
    Amendments to SEC Paragraphs Pursuant to SEC Staff Accounting Bulletin
    No.
    118
    to address the application of GAAP in situations when a registrant does
    not
    have the necessary information available, prepared or analyzed (including computations) in reasonable detail to complete the accounting for certain income tax effects of the Tax Act. As of
    December 31, 2018,
    the Company's analysis for the Transition Tax has been filed with its
    December 31, 2017
    tax return and the Company considered its accounting for this area of the Tax Act to be complete as of such date and did
    not
    make any measurement-period adjustments related to it. In addition, the Company considered its accounting for changes in the U.S. federal rate and deferred tax impact for the rate change to be complete. The Company also accounted for the tax impact related to other areas of the Tax Act and believe its analysis to be completed consistent with the guidance in ASU
    2018
    -
    05.
    The Company recognizes that the IRS is continuing to publish and finalize ongoing guidance with respect to the Act which
    may
    modify accounting interpretation for the Tax Act, the Company would look to account for these impacts in the period of such change is enacted.
     
    Non-employee Stock-based Compensation
    In
    June 2018,
    the FASB issued ASU
    2018
    -
    07,
    Improvements to Nonemployee Share-Based Payment Accounting,
    which more closely aligns the accounting for employee and nonemployee stock-based compensation. Under the new standard, companies are
    no
    longer required to value non-employee awards differently from employee awards. The Company adopted this accounting standard update on
    January 1, 2018
    using a modified retrospective approach. Adoption of this ASU did
    not
     impact the Company's consolidated financial position, results of operations or cash flows.
     
    Recent Accounting Standards or Updates
    Not
    Yet Effective
     
    Leases
    In
    February 2016,
    the FASB issued ASU
    2016
    -
    02,
     
    Leases (Topic
    842
    ),
     as subsequently updated, with fundamental changes as to how entities account for leases. Lessees will need to recognize a right-of-use asset and a lease liability for virtually all of their leases (other than leases that meet the definition of a short-term lease). The liability will be equal to the present value of lease payments. The asset will be based on the liability, subject to adjustment, such as for initial direct costs. Additional disclosures for leases will also be required.
     
    The Company is adopting the new standard effective
    January 1, 2019
    using a modified retrospective method, and will
    not
    restate comparative periods. The modified retrospective transition approach requires lessees and lessors to recognize and measure existing leases at the date of initial application. The new standard provides a number of optional practical expedients in transition. The Company expects to elect the “package of practical expedients”, which permits it
    not
    to reassess under the new standard prior conclusions about lease identification, lease classification and initial direct costs.
     
    The adoption of this standard on
    January 1, 2019
    is expected to have the effect of increasing assets and liabilities on the consolidated balance sheet by
    $25.7
    million, but is
    not
    expected to have a material impact on the consolidated statements of operations or cash flows. The most significant impact relates to (i) the recognition of new Right of Use (ROU) assets and lease liabilities on the balance sheet for operating leases; and (ii) providing significant new disclosures about leasing activities. Upon adoption, the Company will recognize operating lease liabilities of
    $33.6
    million, based on the present value of the remaining minimum rental payments under current leasing standards for existing operating leases. The Company will also recognize ROU assets of
    $29.7
    million, which represents the operating lease liability adjusted for accrued rent.
     
    Financial Instruments with "Down Round" Features
    In
    July 2017,
    the FASB issued ASU
    2017
    -
    11,
     
    Earnings Per Share (Topic
    260
    ); Distinguishing Liabilities from Equity (Topic
    480
    ); Derivatives and Hedging (Topic
    815
    ): Accounting for Certain Financial Instruments with Down Round Features
    . The amendments of this ASU update the classification analysis of certain equity-linked financial instruments, or embedded features, with down round features, as well as clarify existing disclosure requirements for equity-classified instruments. When determining whether certain financial instruments should be classified as liabilities or equity instruments, a down round feature
    no
    longer precludes equity classification when assessing whether the instrument is indexed to an entity’s own stock. The accounting standard update will be effective beginning in the
    first
    quarter of fiscal year
    2019
    using a modified retrospective approach. The Company completed its assessment of the new standard and determined the impact to the consolidated balance sheet would be material. The Company anticipates recording a
    $41.0
    million reduction to derivative liabilities and a corresponding
    $41.0
    million increase to equity on
    January 1, 2019.
     
    Fair Value Measurement
    In
    August 2018,
    the FASB issued ASU
    2018
    -
    13,
    Fair Value Measurement (Topic
    820
    ): Disclosure Framework—Changes to the Disclosure Requirements for Fair Value Measurement
    , which amends ASC
    820,
    Fair Value Measurement
    . ASU
    2018
    -
    13
    modifies the disclosure requirements for fair value measurements by removing, modifying or adding certain disclosures. The accounting standard update will be effective beginning in the
    first
    quarter of fiscal year
    2020,
    with removed and modified disclosures to be adopted on a retrospective basis, and new disclosures to be adopted on a prospective basis. The Company is in the initial stages of evaluating the impact of the new standard on its consolidated financial statements.
     
    Collaborative Revenue Arrangements
    In
    November 2018,
    the FASB issued ASU
    2018
    -
    18,
    Clarifying the Interaction between Topic
    808
    and Topic
    606
    , that clarifies the interaction between the guidance for certain collaborative arrangements and Topic
    606,
    the new revenue recognition standard. A collaborative arrangement is a contractual arrangement under which
    two
    or more parties actively participate in a joint operating activity and are exposed to significant risks and rewards that depend on the activity’s commercial success. The ASU provides guidance on how to assess whether certain transactions between collaborative arrangement participants should be accounted for within the revenue recognition standard. The accounting standard update will be effective beginning in the
    first
    quarter of fiscal year
    2020
    retroactively. The Company does
    not
    believe that the impact of the new standard on its consolidated financial statements will be material.
     
    Credit Losses
    In
    June 2016,
    the FASB issued ASU
    2016
    -
    13,
    Financial Instruments—Credit Losses (Topic
    326
    ), Measurement of Credit Losses on Financial Instruments
    . ASU
    2016
    -
    13
    requires entities to measure all expected credit losses for most financial assets held at the reporting date based on an expected loss model which includes historical experience, current conditions, and reasonable and supportable forecasts. Entities will now use forward-looking information to better form their credit loss estimates. ASU
    2016
    -
    13
    also requires enhanced disclosures to help financial statement users better understand significant estimates and judgments used in estimating credit losses, as well as the credit quality and underwriting standards of an entity's portfolio. ASU
    2016
    -
    13
    will become effective for the Company beginning in the
    first
    quarter of fiscal year
    2020.
    The Company does
    not
    believe that the impact of the new standard on its consolidated financial statements will be material.
    XML 70 R22.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 13 - Divestiture
    12 Months Ended
    Dec. 31, 2018
    Notes to Financial Statements  
    Disposal Groups, Including Discontinued Operations, Disclosure [Text Block]
    13.
    Divestiture
     
    On
    December 28, 2017,
    the Company completed the sale of its subsidiary Amyris Brasil Ltda. (Amyris Brasil), which operated the Company’s production facility located in Brotas, Brazil, to DSM and concurrently entered into a series of commercial agreements and a credit agreement with DSM. At closing, the Company received
    $33.0
    million in contractual cash consideration for the capital stock of Amyris Brasil, which was subject to certain post-closing working capital adjustments; and reimbursements contingent upon DSM’s utilization of certain Brazilian tax benefits it acquired with its purchase of Amyris Brasil. The Company used
    $12.6
    million of the cash proceeds received to repay certain indebtedness of Amyris Brasil. The total fair value of the contractual consideration received by the Company for Amyris Brasil was
    $56.9
    million and resulted in a pretax gain of
    $5.7
    million from continuing operations. In
    November 2018,
    the Company paid DSM
    $1.8
    million related to the final post-closing working capital adjustment. In connection with the payment,
    $1.8
    million was recorded as a loss on divestiture in the
    2018
    consolidated statement of operations, in the line captioned "(Loss) gain on divestiture".
     
    Concurrent with the sale of Amyris Brasil, the Company and DSM entered into a series of commercial agreements including (i) a license agreement to DSM of its farnesene product for DSM to use in the Vitamin E and lubricant markets; (ii) a royalty agreement, pursuant to which DSM agreed to pay the Company specified royalties representing a portion of the profit on the sale of Vitamin E produced from farnesene sold under the Nenter Supply Agreement assigned to DSM; (iii) a performance agreement for the Company to perform research and development to optimize farnesene for production and sale of farnesene products; and (iv) a transition services agreement for the Company to provide finance, legal, logistics, and human resource services to support the Brotas facility under DSM ownership for a
    six
    -month period with a DSM option to extend for
    six
    additional months (see Note
    10,
    “Revenue Recognition” and Note
    16,
    “Subsequent Events” for additional information). At closing, DSM paid the Company a nonrefundable license fee of
    $27.5
    million and a nonrefundable royalty payment of
    $15.0
    million. DSM also paid the Company a nonrefundable minimum annual royalty payment in
    2018
    and will pay a nonrefundable minimum annual royalty payment in
    2019.
    The future nonrefundable minimum annual royalty payments were determined to be fixed and determinable with a fair value of
    $17.8
    million and were included as part of the total arrangement consideration subject to allocation of this overall multiple-element divestiture transaction. See Note
    10,
    “Revenue Recognition” and Note
    11,
    "Related Party Transactions" for a full listing and details of agreements entered into with DSM. Additionally, the Company and DSM entered into a
    $25.0
    million credit agreement that the Company used to repay all outstanding amounts under the Guanfu Note; see Note
    5,
    “Debt” for additional information.
     
    The Company accounted for the sale of Amyris Brasil as a sale of a business for proceeds of
    $54.8
    million. The agreements entered into concurrently with the sale of Amyris Brasil including the license agreement, royalty agreement, performance agreement, transition services agreement, and credit agreement contain various elements and, as such, are deemed to be an arrangement with multiple deliverables as defined under U.S. GAAP. The Company performed an analysis to determine the fair value for all elements in the agreements with DSM and separated the elements between the non-revenue and revenue elements. After allocating the total fair value of the non-revenue elements from the fixed and determinable consideration received, the Company allocated the remaining fixed and determinable consideration to the revenue elements based on relative fair value. As such, the Company recognized
    $54.7
    million of license revenue and
    $2.1
    million of deferred revenue related to the performance option and transition services agreements with DSM as of
    December 31, 2017.
     
    Results from the operations of Amyris Brasil are included in the Company's Consolidated Statements of Operations for
    2017,
    and the Company has
    not
    segregated the results of operations or net assets of Amyris Brasil on the Company's consolidated financial statements for any period presented. The disposition of the assets and liabilities of Amyris Brasil did
    not
    qualify for classification as a discontinued operation as it did
    not
    represent a strategic shift that will have a major effect on the Company’s operations and financial results.
    XML 71 R39.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 15 - Geographical Information (Tables)
    12 Months Ended
    Dec. 31, 2018
    Notes Tables  
    Schedule of Disclosure on Geographic Areas, Long-Lived Assets in Individual Foreign Countries by Country [Table Text Block]
    December 31,
    (In thousands)
      2018   2017
               
    (As Restated, Note 2)
    United States   $
    13,111
        $
    10,357
     
    Brazil    
    6,447
         
    3,357
     
    Europe    
    198
         
    178
     
        $
    19,756
        $
    13,892
     
    XML 72 R31.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 5 - Debt (Tables)
    12 Months Ended
    Dec. 31, 2018
    Notes Tables  
    Schedule of Debt [Table Text Block]
    December 31,

    (In thousands)
      2018   2017
        Principal   Unamortized
    Debt
    (Discount)
    Premium
      Change in
    Fair Value
      Net   Principal   Unamortized
    Debt
    (Discount)
    Premium
      Net
    Convertible notes payable    
     
         
     
         
     
         
     
         
     
       
    (As Restated, Note 2)
       
     
     
    6% convertible notes due 2021   $
    60,000
        $
        $
    (2,082
    )   $
    57,918
        $
        $
     
      $
     
    2015 Rule 144A convertible notes    
    37,887
         
    (2,413
    )    
         
    35,474
         
    37,887
         
    (9,458
    )
       
    28,429
     
    2014 Rule 144A convertible notes    
    24,004
         
    (867
    )    
         
    23,137
         
    24,004
         
    (3,170
    )
       
    20,834
     
    August 2013 financing convertible notes    
    4,415
         
    (70
    )    
         
    4,345
         
    4,009
         
    (2,126
    )
       
    1,883
     
    December 2017 convertible notes    
         
         
         
         
    5,000
         
    (25
    )
       
    4,975
     
         
    126,306
         
    (3,350
    )    
    (2,082
    )    
    120,874
         
    70,900
         
    (14,779
    )
       
    56,121
     
    Related party convertible notes payable                                                        
    2014 Rule 144A convertible notes    
    24,705
         
    (1,038
    )    
         
    23,667
         
    24,705
         
    (3,784
    )
       
    20,921
     
    August 2013 financing convertible notes    
         
         
         
         
    21,711
         
    897
     
       
    22,608
     
    R&D note    
         
         
         
         
    3,700
         
    (18
    )
       
    3,682
     
         
    24,705
         
    (1,038
    )    
         
    23,667
         
    50,116
         
    (2,905
    )
       
    47,211
     
    Loans payable and credit facilities                                                        
    GACP term loan facility    
    36,000
         
    (1,349
    )    
         
    34,651
         
         
     
       
     
    Ginkgo note    
    12,000
         
    (4,047
    )    
         
    7,953
         
    12,000
         
    (4,862
    )
       
    7,138
     
    Other loans payable    
    4,910
         
    (1,047
    )    
         
    3,863
         
    6,463
         
    (1,277
    )
       
    5,186
     
    Senior secured loan facility    
         
         
         
         
    28,566
         
    (253
    )
       
    28,313
     
    Other credit facilities    
         
         
         
         
    381
         
     
       
    381
     
         
    52,910
         
    (6,443
    )    
         
    46,467
         
    47,410
         
    (6,392
    )
       
    41,018
     
    Related party loans payable                                                        
    DSM note    
    25,000
         
    (6,311
    )    
         
    18,689
         
    25,000
         
    (8,039
    )
       
    16,961
     
    February 2016 private placement    
         
         
         
         
    2,000
         
     
       
    2,000
     
    Other DSM loan    
         
         
         
         
    393
         
     
       
    393
     
         
    25,000
         
    (6,311
    )    
         
    18,689
         
    27,393
         
    (8,039
    )
       
    19,354
     
    Total debt   $
    228,921
        $
    (17,142
    )   $
    (2,082
    )    
    209,697
        $
    195,819
        $
    (32,115
    )
       
    163,704
     
    Less: current portion    
     
         
     
         
     
         
    (147,677
    )    
     
         
     
     
       
    (56,943
    )
    Long-term debt, net of current portion    
     
         
     
         
     
        $
    62,020
         
     
         
     
     
      $
    106,761
     
    Schedule of Long-term Debt Instruments [Table Text Block]
    Years ending December 31
    (In thousands)
      Convertible Notes   Loans
    Payable and Credit Facilities
      Related Party Convertible Notes   Related Party Loans Payable and Credit Facilities   Total
    2019   $
    134,368
        $
    10,219
        $
    25,508
        $
    2,500
        $
    172,595
     
    2020    
         
    9,981
         
         
    2,500
         
    12,481
     
    2021    
         
    34,740
         
         
    27,521
         
    62,261
     
    2022    
         
    13,417
         
         
         
    13,417
     
    2023    
         
    367
         
         
         
    367
     
    Thereafter    
         
    2,200
         
         
         
    2,200
     
    Total future minimum payments    
    134,368
         
    70,924
         
    25,508
         
    32,521
         
    263,321
     
    Less: amount representing interest
    (1)
       
    (7,368
    )    
    (18,014
    )    
    (803
    )    
    (7,521
    )    
    (33,706
    )
    Less: future conversion of accrued interest to principal    
    (694
    )    
         
         
         
    (694
    )
    Present value of minimum debt payments    
    126,306
         
    52,910
         
    24,705
         
    25,000
         
    228,921
     
    Less: current portion of debt principal    
    (126,306
    )    
    (3,829
    )    
    (24,705
    )    
         
    (154,840
    )
    Noncurrent portion of debt principal   $
        $
    49,081
        $
        $
    25,000
        $
    74,081
     
    XML 73 R35.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 10 - Revenue Recognition (Tables)
    12 Months Ended
    Dec. 31, 2018
    Notes Tables  
    Disaggregation of Revenue [Table Text Block]
    Years Ended December 31,
    (In thousands)
      2018   2017
            (As Restated, Note 2)
    Europe   $
    29,405
        $
    23,823
     
    United States    
    26,241
         
    78,286
     
    Asia    
    6,331
         
    23,290
     
    Brazil    
    942
         
    2,159
     
    Other    
    685
         
    113
     
        $
    63,604
        $
    127,671
     
    Revenue in Connection with Significant Revenue Agreement [Table Text Block]
    Years Ended December 31,
    (In thousands)
      2018   2017 (As Restated, Note 2)
        Renewable Products   Licenses and Royalties   Grants and Collaborations   TOTAL   Renewable Products   Licenses and Royalties   Grants and Collaborations   TOTAL
    Revenue from significant revenue agreements with:                                                                
    DSM (related party)   $
    18
        $
    5,958
        $
    4,735
        $
    10,711
        $
        $
    57,972
        $
    1,679
        $
    59,651
     
    Firmenich    
    3,727
         
    1,700
         
    5,717
         
    11,144
         
    9,621
         
    1,199
         
    5,803
         
    16,623
     
    DARPA    
         
         
    8,436
         
    8,436
         
         
         
    12,333
         
    12,333
     
    Givaudan    
    4,078
         
         
    4,358
         
    8,436
         
    1,950
         
         
    6,000
         
    7,950
     
    Nenter    
         
         
         
         
    12,057
         
    2,633
         
         
    14,690
     
    Ginkgo    
         
         
         
         
         
    (13,113
    )    
         
    (13,113
    )
    Subtotal revenue from significant revenue agreements    
    7,823
         
    7,658
         
    23,246
         
    38,727
         
    23,628
         
    48,691
         
    25,815
         
    98,134
     
    Revenue from all other customers    
    25,775
         
         
    (898
    )    
    24,877
         
    18,742
         
    12
         
    10,783
         
    29,537
     
    Total revenue from all customers   $
    33,598
        $
    7,658
        $
    22,348
        $
    63,604
        $
    42,370
        $
    48,703
        $
    36,598
        $
    127,671
     
    Contract with Customer, Asset and Liability [Table Text Block]
    December 31,
    (In thousands)
      2018   2017
    Accounts receivable, net   $
    16,003
        $
    18,953
     
    Accounts receivable - related party, net   $
    1,349
        $
    4,767
     
    Accounts receivable, unbilled - related party   $
    8,021
        $
    9,901
     
    Accounts receivable, unbilled, noncurrent - related party   $
    1,203
        $
    7,940
     
    Contract liabilities
    (1)
      $
    8,236
        $
    4,308
     
    Contract liabilities, noncurrent
    (2)
      $
    1,587
        $
     
    Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Table Text Block]
    (In thousands)
      As of December 31, 2018
    2019   $
    14,131
     
    2020    
    7,925
     
    2021    
     
    2022 and thereafter    
     
    Total from all customers   $
    22,056
     
    XML 74 R16.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 7 - Stockholders' Deficit
    12 Months Ended
    Dec. 31, 2018
    Notes to Financial Statements  
    Stockholders' Equity Note Disclosure [Text Block]
    7.
    Stockholders’ Deficit
     
    Warrants
     
    The Company issues warrants in certain debt and equity transactions in order to facilitate raising equity capital or reduce borrowing costs. In connection with various debt and equity transactions (see Note
    5,
    "Debt" and below), the Company has issued warrants exercisable for shares of common stock. The
    May 2017
    and
    August 2017
    cash and dilution warrants, and the
    July 2015
    related party debt exchange warrants are accounted for as derivative liabilities. See the Temasek Funding Warrant and Series A and B sections below for more information. The following table summarizes warrant activity for the year ended
    December 
    31,
    2018:
     
     
    Transaction   Number Outstanding as of
    December 31, 2017
      Additional
    Warrants Issued
      Exercises   Number Outstanding as of
    December 31, 2018
    August 2018 warrant exercise agreements    
         
    12,097,164
         
         
    12,097,164
     
    May 2017 cash and dilution warrants    
    18,042,568
         
         
    (11,749,770
    )    
    6,292,798
     
    August 2017 cash and dilution warrants    
    9,543,234
         
    1,713,565
         
    (7,288,683
    )    
    3,968,116
     
    April 2018 warrant exercise agreements    
         
    3,616,174
         
         
    3,616,174
     
    July 2015 related party debt exchange    
    2,082,010
         
    471,204
         
    (1,889,986
    )    
    663,228
     
    February 2016 related party private placement    
    171,429
         
         
         
    171,429
     
    July 2015 private placement    
    81,197
         
         
         
    81,197
     
    Other    
    1,406
         
         
         
    1,406
     
         
    29,921,844
         
    17,898,107
         
    (20,928,439
    )    
    26,891,512
     
     
    For information regarding warrants issued subsequent to
    December 31, 2018,
    see Note
    16,
    “Subsequent Events”.
     
    Shares Issuable under Convertible Notes
     
    In connection with various debt transactions (see Note
    5,
    "Debt"), the Company issued certain convertible notes that are convertible into shares of common stock as follows as of
    December 
    31,
    2018,
    at any time at the election of each debtholder:
     
    Debt Instrument   Number of Shares into Which
    Debt Instrument Is Convertible
    as of December 31, 2018
    6% convertible notes due 2021    
    9,493,672
     
    2015 Rule 144A convertible notes    
    2,338,560
     
    August 2013 financing convertible notes    
    1,003,554
     
    2014 Rule 144A convertible notes    
    867,376
     
         
    13,703,162
     
     
    2018
    Warrant Exercises and New Warrant Issuances
     
    April 2018
    Warrant Transactions
     
    On
    April 12, 2018,
    in accordance with the terms of the Warrant Exercise Agreement, certain holders of the
    May 2017
    Warrants (see below under
    “May 2017
    Offerings”) exercised their
    May 2017
    Cash Warrants in full to purchase an aggregate of
    3,616,174
    shares of common stock for net proceeds to the Company of
    $14.5
    million and surrendered their
    May 2017
    Dilution Warrants for cancellation. Upon exercise of the
    May 2017
    Cash Warrants and surrender of such
    May 2017
    Dilution Warrants, certain derivative liabilities representing certain anti-dilution rights contained in the
    May 2017
    Warrants were effectively settled. Under the terms of the Warrant Exercise Agreements, the exercise of such
    May 2017
    Cash Warrants and surrender of such
    May 2017
    Dilution Warrants was required on the date of the Warrant Exercise Agreement in order for the Company to issue new warrants to these same holders to purchase an aggregate of
    3,616,174
    shares of common stock, exercisable at a price of
    $7.00
    per share. The new warrants were fully exercisable upon issuance, with an expiration date of
    July 12, 2019.
    The new warrants do
    not
    provide the holders with anti-dilution protection and only permit “cashless” exercise after the
    six
    -month anniversary of issuance, and only to the extent that there is
    not
    an effective registration statement covering the resale of the shares of common stock underlying the new warrants; on
    September 26, 2018,
    the Company filed such a registration statement, which was declared effective on
    October 11, 2018.
    The new warrants were evaluated for liability classification, and while meeting the definition of a derivative, the freestanding instruments met the indexation and equity classification criteria to be accounted for as equity.
     
    August 2018
    Warrant Transactions
     
    In
    August 2018
    in accordance with the terms of the Warrant Exercise Agreements, Foris Ventures, LLC (Foris) and entities affiliated with Vivo Capital LLC (Vivo), related parties and holders of the
    May 2017
    Warrants and
    August 2017
    Warrants (see below under
    “August 2017
    Vivo Offering”), respectively, exercised their Cash Warrants and, in the case of Foris, Dilution Warrants in full and in accordance with the terms of the Warrant Exercise Agreements, to purchase an aggregate of approximately
    12.6
    million shares of common stock for
    $43.0
    million in proceeds to the Company, and Vivo subsequently surrendered their Dilution Warrants for cancellation. In connection with the entry by the Company and Vivo into Warrant Exercise Agreement, the Company and Vivo amended the
    August 2017
    Vivo Cash Warrants to (i) reduce the exercise price of such warrants from
    $6.39
    per share to
    $4.40
    per share and (ii) remove the
    August 2017
    Vivo Offering Beneficial Ownership Limitation from such warrants. Upon exercise and surrender of such Cash Warrants and Dilution Warrants, certain derivative liabilities representing certain anti-dilution rights contained in the
    May 2017
    Warrants and
    August 2017
    Warrants were effectively settled. Under the terms of the Warrants Exercise Agreement, the exercise of the Cash Warrants and Dilution Warrants and subsequent surrender of the Vivo Dilution Warrants was required on the date of the Warrants Exercise Agreement in order for the Company to issue a series of new warrants to these same holders to purchase an aggregate of
    12.1
    million shares of common stock, exercisable at
    $7.52
    per share. The new warrants are exercisable any time after the
    six
    -month anniversary of issuance and for
    15
    months thereafter, with an expiration date in
    May 2020.
    The new warrants do
    not
    provide the holders with anti-dilution protection and only permit “cashless” exercise after the
    twelve
    -month anniversary of issuance, and only to the extent that there is
    not
    an effective registration statement covering the resale of the shares of common stock underlying the new warrants. The new warrants were evaluated for liability classification, and while meeting the definition of a derivative, the freestanding instruments met the indexation and equity classification criteria to be accounted for as equity.
     
    Temasek Funding Warrant – Related Party
     
    Following amendments to certain common stock purchase warrants in
    August 2018 (
    see below under
    “May 2017
    Offerings” and
    “August 2017
    Vivo Offering”), and a corresponding adjustment to the conversion price of the
    August 2013
    financing convertible notes from
    $5.2977
    per share to
    $4.40
    per share (see Note
    5,
    “Debt”), the Temasek Funding Warrant became exercisable for an additional
    471,204
    shares of common stock in accordance with its terms. On
    October 19, 2018,
    Temasek exercised the Temasek Funding Warrant with respect to
    1,889,986
    shares of common stock underlying the Temasek Funding Warrant by means of a cashless exercise, resulting in the issuance of
    1,852,585
    shares of common stock to Temasek. As of
    December 31, 2018,
    there were
    471,204
    shares underlying the Temasek Funding Warrant. As a result of this exercise, the derivative liability related to the Temasek Funding Warrant decreased by
    $14.0
    million.
     
    November 2018
    DSM Securities Purchase Agreement – Related Party
     
    On
    November 20, 2018,
    the Company issued
    1,643,991
    shares of common stock (the DSM Shares) at
    $3.68
    per share to DSM in a private placement pursuant to a securities purchase agreement, dated
    November 19, 2018,
    between the Company and DSM (the DSM SPA), in consideration of certain agreements of DSM set forth in the Supply Agreement Amendment described in Note
    10,
    "Revenue Recognition". The Company also agreed to pay DSM the difference between the DSM SPA purchase price of
    $4.41
    and the closing share price of the Company's common stock on
    March 28, 2019,
    multiplied by
    1,643,991.
    At inception, the Company recorded a
    $1.2
    million derivative liability for the difference between
    $4.41
    and the Company’s closing stock price on
    November 20, 2018.
    At
    December 31, 2018
    fair value based on the Company’s closing stock price was
    $1.8
    million, resulting in a
    $0.6
    million loss on change in fair value for the year ended
    December 31, 2018.
    At
    March 28, 2019,
    the Company's stock price was
    $2.10,
    and the Company owed DSM
    $3.8
    million in connection with this agreement. Pursuant to the DSM SPA, the Company agreed to file a registration statement providing for the resale by DSM of the DSM Shares and to use commercially reasonable efforts to (i) cause such registration statement to become effective within
    181
    days following the date of the DSM SPA and (ii) keep such registration statement effective until DSM does
    not
    own any DSM Shares or the DSM Shares are eligible for resale under Rule
    144
    without regard to volume limitations. See Note
    11,
    "Related Party Transactions" for additional information about the accounting for this transaction and other
    November 2018
    transactions with DSM. In
    April 2019,
    in connection with the assignment by the Company of its rights under the Value Sharing Agreement (see Note
    10,
    "Revenue Recognition"), the Company satisfied its obligation under the Supply Agreement Amendment relating to the difference between
    $4.41
    and the price of the Company’s common stock on
    March 28, 2019.
    See Note
    16,
    “Subsequent Events” for additional information.
     
    At
    Market Issuance Sales
    Agreement
     
    On
    March 8, 2016,
    the Company entered into an At Market Issuance Sales Agreement (ATM Sales Agreement) with FBR Capital Markets & Co. and MLV & Co. LLC (Agents) under which the Company would be able to issue and sell shares of its common stock having an aggregate offering price of up to
    $50.0
    million (ATM Shares) from time to time through the Agents, acting as its sales agents, under the Company's Registration Statement on Form S-
    3
    (File
    No.
    333
    -
    203216
    ), effective
    April 15, 2015.
    Sales of the ATM Shares through the Agents would be made by any method that is deemed an "at the market offering" as defined in Rule
    415
    under the Securities Act of
    1933,
    as amended, including by means of ordinary brokers' transactions at market prices, in block transactions, or as otherwise agreed by the Company and the Agents. The Company agreed to pay the applicable Agent a commission rate of up to
    3.0%
    of the gross proceeds from the sale of any ATM Shares sold through such Agent under the ATM Sales Agreement. The ATM Sales Agreement included
    no
    commitment by other parties to purchase ATM Shares the Company offers for sale.
     
    During the year ended
    December 
    31,
    2018,
    the Company issued and sold 
    205,168
    shares of common stock under the ATM Sales Agreement, at an average price of 
    $6.90
    per share, resulting in total net proceeds to the Company of
    $1.4
    million.
    During
    the year ended
    December 
    31,
    2017,
    the Company did
    not
    sell any shares of common stock under the ATM Sales Agreement. The ATM Sales Agreement expired on
    April 15, 2018,
    and as a result,
    zero
    remained available for issuance under the ATM Sales Agreement as of
    December 
    31,
    2018.
     
    May 2017
    Offerings
     
    In
    May 2017,
    the Company issued and sold an aggregate of
    22,140
    shares of Series A
    17.38%
    Convertible Preferred Stock (Series A Preferred Stock),
    70,904
    shares of Series B
    17.38%
    Convertible Preferred Stock (Series B Preferred Stock), and warrants to purchase an aggregate of
    7,384,190
    shares of common stock at an initial exercise price of
    $7.80
    per share, warrants to purchase an aggregate of
    7,384,190
    shares of common stock at an initial exercise price of
    $9.30
    per share, and warrants to purchase a number of shares of common stock sufficient to provide full-ratchet anti-dilution protection with respect to the effective price paid for the common stock underlying the Series A Preferred Stock and Series B Preferred Stock (collectively, the
    May 2017
    Warrants) in separate offerings, certain of which were registered under the Securities Act or others of which were private placements (collectively, the
    May 2017
    Offerings).
     
    The
    net proceeds to the Company from the
    May 2017
    Offerings were
    $50.7
    million after payment of offering expenses and placement agent fees. The Series A Preferred Stock and
    May 2017
    Warrants relating thereto were sold to the purchasers thereof in exchange for aggregate cash consideration of
    $22.1
    million, and the Series B Preferred Stock and
    May 2017
    Warrants relating thereto were sold to the purchasers thereof in exchange for (i) aggregate cash consideration of
    $30.7
    million and (ii) the cancellation of
    $40.2
    million of outstanding indebtedness (including accrued interest thereon) owed by the Company to certain purchasers, of which
    $33.1
    million was from related parties, as further described below.
     
    Series A and B Preferred Stock
     
    Series A Prefer
    red Stock
     
    Each share of Series A Preferred Stock has a stated value of
    $1,000
    and is convertible at any time, at the option of the holder, into common stock at a conversion price of
    $17.25
    per share (Preferred Stock Conversion Rate). The Preferred Stock Conversion Rate is subject to adjustment in the event of any dividends or distributions of common stock, or any stock split, reverse stock split, recapitalization, reorganization or similar transaction. If
    not
    previously converted at the option of the holder, each share of Series A Preferred Stock automatically converted on
    October 9, 2017,
    the
    90th
    day following the date that the
    July 2017
    Stockholder Approval (as defined below) was obtained and effected, subject to the
    May 2017
    Offerings Beneficial Ownership Limitation (as defined below).
     
    Dividends, at a rate per year equal to
    17.38%
    of the stated value of the Series A Preferred Stock, will be payable semiannually from the issuance of the Series A Preferred Stock until the
    tenth
    anniversary of the date of issuance, on each
    October 15
    and
    April 15,
    beginning
    October 15, 2017,
    on a cumulative basis, at the Company's option, in cash, out of any funds legally available for the payment of dividends, or, subject to the satisfaction of certain conditions, in Common Stock at the Preferred Stock Conversion Rate, or a combination thereof. Upon the conversion of the Series A Preferred Stock prior to the
    tenth
    anniversary of the date of issuance, the holders of the Series Preferred A Stock shall be entitled to a payment equal to
    $1,738
    per
    $1,000
    of stated value of the Series A Preferred Stock, less the amount of all prior semiannual dividends paid on such converted Series A Preferred Stock prior to the relevant conversion date (Make-Whole Payment), at the Company's option, in cash, out of any funds legally available for the payment of dividends, or, subject to the satisfaction of certain conditions, in common stock at the Preferred Stock Conversion Rate, or a combination thereof. If the Company elects to pay any dividend in the form of cash, it shall provide each holder with notice of such election
    not
    later than the
    first
    day of the month of prior to the applicable dividend payment date.
     
    Unless and until converted into common stock in accordance with its terms, the Series A Preferred Stock has
    no
    voting rights, other than as required by law or with respect to matters specifically affecting the Series A Preferred Stock.
     
    Upon any liquidation, dissolution or winding-up of the Company, the holders of the Series A Preferred Stock shall be entitled to receive out of the assets of the Company the same amount that a holder of Common Stock would receive if the Series A Preferred Stock were fully converted to common stock immediately prior to such liquidation, dissolution or winding-up (without regard to whether such Series A Preferred Stock is convertible at such time), which amount shall be paid
    pari passu
    with all holders of Common Stock.
     
    The conversion of the Series A Preferred Stock is subject to a beneficial ownership limitation of
    4.99%
    (or such other percentage
    not
    to exceed
    9.99%,
    provided that any increase will
    not
    be effective until
    61
    days after notice thereof by the holder) of the number of shares of common stock outstanding immediately after giving effect to the issuance of shares of common stock issuable upon conversion of such Series A Preferred Stock (
    May 2017
    Offerings Beneficial Ownership Limitation). In addition, prior to obtaining the
    July 2017
    Stockholder Approval (as defined below), the aggregate number of shares issued with respect to the Series A Preferred Stock (and any other transaction aggregated for such purpose) could
    not
    exceed
    3,792,778
    shares of common stock (
    May 2017
    Exchange Cap).
     
    The Series A Preferred Stock is classified as permanent equity, as the Company controls all actions or events required to settle the optional and mandatory conversion feature in shares. The Make-Whole Payment was determined to be an embedded derivative requiring bifurcation and separate recognition as a derivative liability recognized at its fair value as of the issuance date with subsequent changes in fair value recorded in earnings until the earlier of (i)
    July 7, 2017
    when the Make-Whole shares became fixed and certain, (ii) the Series A Preferred Stock is converted into common stock, (iii) the Make-Whole Payment is voluntarily converted, or (iv) the Make-Whole Payment is paid through declared dividends or cash. A derivative liability was recognized at fair value on the date of issuance for the Make-Whole Payment in the amount of
    $11.0
    million. The value of the remaining Make-Whole derivative liability at
    July 7, 2017
    was extinguished to equity. All Make-Whole Payment conversions into common stock before and after
    July 7, 2017,
    were accounted for as a deemed dividend in the period converted. A derivative liability was also recognized at fair value on the date of issuance for the
    May 2017
    Warrants issued to the Series A holders (discussed more fully below) in the amount of
    $10.6
    million. The Series A Preferred Stock also contained a beneficial conversion feature which was recognized up to the amount of
    $0.6
    million of proceeds allocated to the preferred stock. Net proceeds allocated to the Series A Preferred Stock were
    $0.6
    million.
     
    As of
    December 31, 2017,
    all
    22,140
    shares of Series A Preferred Stock had been converted into common stock (with the Make-Whole Payment in each case being made in the form of common stock) and
    zero
    shares of Series A Preferred Stock were outstanding. Upon conversion of the Series A Preferred Shares, the Company recognized a deemed dividend for the unamortized discount related to the allocation of proceeds to the
    May 2017
    Warrants derivatives totaling
    $21.6
    million, and deemed dividends upon settlement of the Series A Make-Whole Payment totaling
    $10.5
    million, all as a reduction to Additional Paid-in Capital and an increase to net loss attributable to Amyris, Inc. common stockholders.
     
    Series B Preferred Stock
     
    The Series B Preferred Stock has substantially identical terms to the Series A Preferred Stock, except that (i) the conversion of the Series B Preferred Stock was subject to the
    July 2017
    Stockholder Approval and (ii) the
    May 2017
    Offerings Beneficial Ownership Limitation does
    not
    apply to DSM. The Series B Preferred Stock was classified as permanent equity at issuance due to the lack of a cash redemption feature and because the holder’s only recourse to affect conversion was to require the Company to continually seek shareholder approval, thus effectively giving the Company control over the actions or events necessary to settle an optional or mandatory conversion feature in shares. As described in more detail below under
    “July 2017
    Stockholder Approval,” in
    July 2017
    the Company’s stockholders approved removing a restriction preventing the Series B Preferred Stock issued in the
    May 2017
    Offerings from being convertible into common stock.
     
    The investors that purchased shares of the Series B Preferred Stock included related parties affiliated with members of the Board: Foris exchanged an aggregate principal amount of
    $27.0
    million of indebtedness, plus accrued interest thereon, for
    30,729
    shares of Series B Preferred Stock and
    May 2017
    Warrants to purchase
    4,877,386
    shares of Common Stock and Naxyris exchanged an aggregate principal amount of
    $2.0
    million of indebtedness, plus accrued interest thereon, for
    2,333
    shares of Series B Preferred Stock and
    May 2017
    Warrants to purchase
    370,404
    shares of common stock. The fair value of the Series B Preferred Stock, the embedded Make-Whole payment and the related warrants exceeded the carrying value of the related party debt and accrued interest exchanged by
    $8.6
    million which was recorded as a loss upon extinguishment of debt as the Company determined that the related parties were acting in their interests as debt holders.
     
    The investors that purchased shares of the Series B Preferred Stock also included non-related party holders of the Company's
    2014
    Rule
    144A
    Convertible Notes and
    2015
    Rule
    144A
    Convertible Notes. These investors exchanged all or a portion of their holding of such indebtedness, including accrued interest thereon, representing an aggregate of
    $3.4
    million of
    2014
    Rule
    144A
    Convertible Notes and
    $3.7
    million of
    2015
    Rule
    144A
    Convertible Notes, for Series B Preferred Stock and
    May 2017
    Warrants in the
    May 2017
    Offerings. The fair value of the Series B Preferred Stock, the embedded Make-Whole payment and the related warrants exceeded the carrying value of the debt and accrued interest exchanged by
    $1.9
    million, which was recognized as a loss on extinguishment of debt in other income (expense).
     
    Issuance costs of
    $1.2
    million were netted against the proceeds. Additional issuance costs of
    $0.2
    million were expensed as debt extinguishment costs for debt that was exchanged in the
    May 2017
    Offerings.
     
    Upon the closing of the
    May 2017
    Offerings, all such exchanged indebtedness was canceled and the agreements relating thereto, including any note purchase agreements or unsecured or secured promissory notes (including any security interest relating thereto), were terminated, except to the extent such investors or other investors retain a portion of such indebtedness.
     
    A derivative liability was recognized at fair value on the date of issuance for the
    May 2017
    DSM Series B Make-Whole Payment in the amount of
    $12.4
    million. A derivative liability was also recognized at fair value on the date of issuance for the
    May 2017
    Warrants issued to DSM (discussed more fully below) in the amount of
    $11.9
    million. Upon conversion of the DSM Series B Preferred Shares, the Company recognized a deemed dividend for the unamortized discounts related to the allocation of proceeds to the
    May 2017
    DSM Make-Whole Payment and
    May 2017
    Warrants derivatives totaling
    $24.4
    million, and a deemed dividend upon settlement of all
    May 2017
    Series B Make-Whole Payments totaling
    $22.6
    million, all as a reduction to Additional Paid in Capital and an increase to net loss attributable to Amyris, Inc. common stockholders. The Series B Preferred Stock issued to DSM in the
    May 2017
    Offerings also contained a contingent beneficial conversion feature that was recognized in the
    three
    months ending
    September 30, 2017
    upon the
    July 2017
    Stockholder Approval, which eliminated the contingency. As a result,
    $0.6
    million was recorded as a reduction to Additional Paid in Capital and was considered a deemed dividend, increasing net loss attributable to Amyris, Inc. common stockholders.
     
    As of
    December 
    31,
    2018,
    89,528
    shares of Series B Preferred Stock (including the Series B Preferred Stock issued in the
    August 2017
    DSM Offering) have been converted into common stock (with the Make-Whole Payment in each case being made in the form of common stock) and
    6,376
    shares of Series B Preferred Stock were outstanding. At
    December 31, 2017,
    9,213
    shares of Series B Preferred Stock were outstanding.
     
    May 2017
    Warrants
     
    The Company issued to each investor in the
    May 2017
    Offerings warrants to purchase a number of shares of common stock equal to
    100%
    of the shares of common stock into which such investor's shares of Series A Preferred Stock or Series B Preferred Stock were initially convertible (including shares of common stock issuable as payment of dividends or the Make-Whole Payment, assuming that all such dividends and the Make-Whole Payment are made in common stock), representing warrants to purchase
    14,768,380
    shares of common stock in the aggregate for all investors (collectively, the
    May 2017
    Cash Warrants). The exercise price of the
    May 2017
    Cash Warrants is subject to standard adjustments as well as full-ratchet anti-dilution protection for any issuance by the Company of equity or equity-linked securities during the
    three
    -year period following the issuance of such warrants (
    May 2017
    Dilution Period) at a per share price less than the then-current exercise price of the
    May 2017
    Cash Warrants, subject to certain exceptions. As of
    December 
    31,
    2017,
    the exercise prices of the
    May 2017
    Cash Warrants were
    $4.40
    per share and
    no
    May 2017
    Cash Warrants had been exercised. As of
    December 
    31,
    2018,
    the exercise prices of the
    May 2017
    Cash Warrants were
    $4.40
    per share and
    8,523,560
    May 2017
    Cash Warrants had been exercised (see
    “April 2018
    Warrant Transactions” and
    “August 2018
    Warrant Transactions” above).
     
    In addition, the Company issued to each investor a warrant, with an exercise price of
    $0.0015
    per share as of
    December 
    31,
    2018
    (collectively, the
    May 2017
    Dilution Warrants), to purchase a number of shares of common stock sufficient to provide the investor with full-ratchet anti-dilution protection for any issuance by the Company of equity or equity-linked securities during the
    May 2017
    Dilution Period at a per share price less than
    $6.30,
    the effective per share price paid by the investors for the shares of common stock issuable upon conversion of their Series A Preferred Stock or Series B Preferred Stock (including shares of common stock issuable as payment of dividends or the Make-Whole Payment, assuming that all such dividends and the Make-Whole Payment are made in common stock) subject to certain exceptions. As of
    December 
    31,
    2018,
    the
    May 2017
    Dilution Warrants were exercisable for an aggregate of
    6,377,466
    shares based on an effective per share price of
    $4.40
    per share, of which
    6,329,488
    warrants had been exercised, resulting in a
    $64.1
    million reduction in derivative liability. See
    “April 2018
    Warrant Transactions” and
    “August 2018
    Warrant Transactions” above regarding the cancellation of certain
    May 2017
    Dilution Warrants.
     
    The
    May 2017
    Warrants each have a term of
    five
    years from the date such warrants initially became exercisable upon the receipt and effectiveness of the
    July 2017
    Stockholder Approval. The exercise of the
    May 2017
    Warrants (other than the
    May 2017
    Warrants held by DSM) is subject to the
    May 2017
    Offerings Beneficial Ownership Limitation. In connection with the entry by the Company and Foris into a warrant exercise agreement in
    August 2018
    and related transactions (see
    “August 2018
    Warrant Transactions” above), the Company and Foris amended Foris’s
    May 2017
    Cash Warrants and
    May 2017
    Dilution Warrant to remove the
    May 2017
    Offerings Beneficial Ownership Limitation from such warrants. The
    May 2017
    Cash Warrants are freestanding financial instruments that are accounted for as derivative liabilities and recognized at their fair value on the date of issuance of
    $39.5
    million. As of
    December 
    31,
    2018,
    the fair value of the
    May 2017
    Cash Warrants was
    $24.1
    million, as determined with the assistance of an independent
    third
    -party appraisal.
     
    For the years ended
    December 
    31,
    2018
    and
    2017,
    the Company recorded a loss of
    $13.5
    million and
    $40.4
    million, respectively, to reflect change in fair value of the
    May 2017
    Cash Warrants (including the anti-dilution protection feature). Subsequent changes to the fair value of the
    May 2017
    Cash Warrants will continue to be recorded in earnings until the warrants are exercised or expire in
    July 2022.
     
    July 2017
    Stockholder
    Approval
     
    In connection with the
    May 2017
    Offerings, the Company agreed to solicit from its stockholders (i) any approval required by the rules and regulations of the NASDAQ Stock Market, including without limitation for the issuance of common stock upon conversion of the Series A Preferred Stock in excess of the
    May 2017
    Exchange Cap, upon conversion of the Series B Preferred Stock and upon exercise of the
    May 2017
    Warrants (the NASDAQ Approval) and (ii) approval to effect the Reverse Stock Split (collectively, the
    July 2017
    Stockholder Approval) at an annual or special meeting of stockholders to be held on or prior to
    July 10, 2017,
    and to use commercially reasonable efforts to secure the
    July 2017
    Stockholder Approval. The Reverse Stock Split was approved by the Company’s stockholders in
    May 2017
    and the NASDAQ Approval was obtained on
    July 7, 2017.
     
    August 2017
    DSM Offering
    Related Party
     
    On
    August 7, 2017,
    the Company issued and sold the following securities to
    DSM
    in a private placement (
    August 2017
    DSM Offering):
     
    25,000
    shares of Series B Preferred Stock (
    August 2017
    DSM Series B Preferred Stock) at a price of
    $1,000
    per share;
      a warrant to purchase
    3,968,116
    shares of common stock at an initial exercise price of
    $6.30
    per share expiring in
    five
    years (
    August 2017
    DSM Cash Warrant); and
      the
    August 2017
    DSM Dilution Warrant (as described below).
     
    Net proceeds to the Company were
    $25.9
    million after payment of offering expenses
    and the allocation of total fair value received to the elements in the arrangement.
     
    The exercise price of the
    August 2017
    DSM Cash Warrant is subject to standard adjustments as well as full-ratchet anti-dilution protection for any issuance by the Company of equity or equity-linked securities during the
    three
    -year period following
    August 7, 2017 (
    DSM Dilution Period) at a per share price less than the then-current exercise price of the
    August 2017
    DSM Cash Warrant, subject to certain exceptions. As of
    December 
    31,
    2018,
    the exercise price of the
    August 2017
    DSM Cash Warrant was
    $4.40
    per share.
     
    The
    August 2017
    DSM Dilution Warrant allows DSM to purchase a number of shares of common stock sufficient to provide DSM with full-ratchet anti-dilution protection for any issuance by the Company of equity or equity-linked securities during the DSM Dilution Period at a per share price less than
    $6.30,
    the effective per share price paid by DSM for the shares of common stock issuable upon conversion of its Series B Preferred Stock (including shares of common stock issuable as payment of dividends or the Make-Whole Payment (as defined below), assuming that all such dividends and the Make-Whole Payment are made in common stock), subject to certain exceptions and subject to a price floor of
    $0.10
    per share (Dilution Floor). The
    August 2017
    DSM Dilution Warrant expires
    five
    years from the date it is initially exercisable.
     
    In connection with the
    August 2017
    DSM Offering, the Company also agreed that, subject to certain exceptions, it would
    not
    (i) issue any shares of common stock or securities convertible into or exercisable or exchangeable for common stock prior to
    October 31, 2017, (
    ii) effect any issuance of securities involving a variable rate transaction until
    May 11, 2018
    or (iii) issue any shares of common stock or securities convertible into or exercisable or exchangeable for common stock at a price below the Dilution Floor without DSM's consent. On
    November 19, 2018,
    the Company entered into an agreement to reduce the exercise price of the
    August 2017
    DSM Cash Warrant from
    $6.30
    to
    $4.40
    to compensate DSM for failure to obtain its consent to reduce the exercise price of the Vivo Warrant discussed in the
    “August 2018
    Warrant Transactions” section of this Note
    7
    “Stockholders’ Deficit”. The Company determined the fair value of this agreement to be
    $6.8
    million and recorded a legal settlement expense for the period ended
    December 31, 2018
    in that amount. See Note
    4,
    "Fair Value Measurement" for additional information. The accounting treatment for this transaction was evaluated in conjunction with the other
    November 2018
    transactions discussed in Note
    11,
    “Related Party Transactions”. Also, upon execution of this agreement the
    August 2017
    DSM Dilution Warrant became exercisable for
    1,713,565
    shares based on an effective per share price of
    $0.0001
    per share, all of which were exercised in
    November 2018.
     
    In connection with the
    August 2017
    DSM Offering, the Company and DSM also entered into an amendment to the stockholder agreement dated
    May 11, 2017 (
    DSM Stockholder Agreement) between the Company and DSM (Amended and Restated DSM Stockholder Agreement). Under the DSM Stockholder Agreement, DSM was granted the right to designate
    one
    director selected by DSM, subject to certain restrictions and a minimum beneficial ownership level of
    4.5%,
    to the Board. Furthermore, DSM has the right to purchase additional shares of capital stock of the Company in connection with a sale of equity or equity-linked securities by the Company in a capital raising transaction for cash, subject to certain exceptions, to maintain its proportionate ownership percentage in the Company. Pursuant to the DSM Stockholder Agreement, DSM agreed
    not
    to sell or transfer any of the Series B Preferred Stock or warrants purchased by DSM in the
    May 2017
    Offerings (as defined below), or any shares of common stock issuable upon conversion or exercise thereof, other than to its affiliates, without the consent of the Company through
    May 2018
    and to any competitor of the Company thereafter. DSM also agreed that, subject to certain exceptions, until
    three
    months after there is
    no
    DSM director on the Board, DSM will
    not,
    without the prior consent of the Board, acquire common stock or rights to acquire common stock that would result in DSM beneficially owning more than
    33%
    of the Company’s outstanding voting securities at the time of acquisition. Under the DSM Stockholder Agreement, the Company agreed to use its commercially reasonable efforts to register, via
    one
    or more registration statements filed with the Securities and Exchange Commission (SEC) under the Securities Act of
    1933,
    as amended (Securities Act), the shares of common stock issuable upon conversion or exercise of the securities purchased by DSM in the
    May 2017
    Offerings. The Amended and Restated DSM Stockholder Agreement provides that (i) DSM has the right to designate a
    second
    director to the Board, subject to certain restrictions and a minimum beneficial ownership level of
    10%,
    and (ii) the shares of common stock issuable upon conversion or exercise of the securities purchased by DSM in the
    August 2017
    DSM Offering are (a) entitled to the registration rights provided for in the DSM Stockholder Agreement and (b) subject to the transfer restrictions set forth in the DSM Stockholder Agreement.
     
    In addition, pursuant to the Amended and Restated DSM Stockholder Agreement, the Company and DSM agreed to negotiate in good faith regarding an agreement concerning the development of certain products in the Health & Wellness field and, in the event that the parties did
    not
    reach such agreement prior to
    90
    days after the closing of the
    August 2017
    DSM Offering (
    August 2017
    DSM Closing), (a) certain exclusive negotiating rights granted to DSM in connection with the entry into the DSM Stockholder Agreement would expire and (b) on the
    first
    anniversary of the
    August 2017
    DSM Closing and each subsequent anniversary thereof, the Company would make a
    $5.0
    million cash payment to DSM, provided that the aggregate amount of such payments would
    not
    exceed
    $25.0
    million. In
    September 2017,
    the Company and DSM entered into such agreement, and in connection therewith an intellectual property escrow agreement relating to certain intellectual property licenses granted by the Company to DSM upon the
    August 2017
    DSM Closing became effective.
     
    In connection with the
    August 2017
    DSM Offering and its
    $25.9
    million in net proceeds, the Company also entered into a separate intellectual property license with DSM for consideration of
    $9.0
    million in cash, which DSM remitted to the Company on
    October 28, 2017,
    and a credit letter (DSM Credit Letter) to be applied against future collaboration and royalty payments owed by DSM to the Company beginning in
    2018.
    The DSM Credit Letter had a fair value of
    $7.1
    million and was recorded as deferred revenue on the transaction date. The total fixed consideration of
    $34.0
    million was allocated to each of the
    August 2017
    DSM Series B Preferred Stock,
    August 2017
    DSM Cash Warrant,
    August 2017
    DSM Dilution Warrant and DSM Credit Letter at fair value based on level
    3
    inputs. The
    August 2017
    DSM Series B Preferred Stock was recognized at its fair value on the date of issuance of
    $15.6
    million, net of issuance costs of
    $0.2
    million. The
    August 2017
    Make-Whole Payment met the criteria to be classified in permanent equity and was
    not
    bifurcated from the preferred stock but will be recognized as a deemed dividend upon conversion, increasing the net loss attributable to Amyris, Inc. common stockholders. The
    August 2017
    DSM Cash Warrant and
    August 2017
    DSM Dilution Warrant are freestanding financial instruments and were initially recognized at their fair value of
    $10.6
    million. The
    August 2017
    DSM Cash Warrant and
    August 2017
    DSM Dilution Warrant have been reported together as derivative liabilities. Changes in the fair value of the warrant derivatives for the years ended
    December 
    31,
    2018
    and
    2017
    have been recorded in earnings as a
    $7.5
    million loss and
    $4.0
    million loss, respectively.
     
    As of
    December 
    31,
    2018,
    all the
    August 2017
    Series B Preferred Shares have been converted into common stock.
     
    The DSM Credit Letter was initially recorded as deferred revenue at its
    $7.1
    million fair value, which was determined based on the assumptions that DSM would realize its credit over the next
    18
    months to
    4
    years with a
    50%
    to
    90%
    likelihood the credit will be utilized, fully discounted at the Company's
    8.6%
    average cost of debt. After allocating the
    $34.0
    million in fixed consideration to the financial instruments noted above and the DSM Credit Letter,
    $7.8
    million was available for recognition as revenue related to the intellectual property licenses delivered to DSM, of which
    $3.3
    million was recognized as license revenue during the year ended
    December 31, 2017.
    The DSM Credit Letter was terminated in
    December 2017,
    resulting in the reversal of the remaining unrecognized
    $4.5
    million deferred revenue liability previously recorded as consideration for the DSM License and Collaboration transaction. See Note
    10,
    “Revenue Recognition” for additional information.
     
    August 2017
    Vivo Offering
    Related Party
     
    On
    August 3, 2017,
    the Company issued and sold the following securities to Vivo in a private placement (
    August 2017
    Vivo Offering), resulting in net proceeds to the Company of
    $24.8
    million after payment of offering expenses.
     
    2,826,711
    shares of common stock at a price of
    $4.26
    per share;
     
    12,958
    shares of Series D Preferred Stock at a price of
    $1,000
    per share;
     
    warrants to purchase an aggregate of
    5,575,118
    shares of common stock at an initial exercise price of
    $6.39
    per share, expiring in
    five
    years (
    August 2017
    Vivo Cash Warrants); and
     
    the
    August 2017
    Vivo Dilution Warrants (as described below).
     
    Each share of Series D Preferred Stock has a stated value of
    $1,000
    and, subject to the
    August 2017
    Vivo Offering Beneficial Ownership Limitation (as defined below), is convertible at any time, at the option of the holders, into common stock at a conversion price of
    $4.26
    per share. The Series D Conversion Rate is subject to adjustment in the event of any dividends or distributions of the common stock, or a
    ny stock split, reverse stock split, recapitalization, reorganization or similar transaction.
     
    Prior
    to declaring any dividend or other distribution of its assets to holders of common stock, the Company shall
    first
    declare a dividend per share on the Series D Preferred Stock equal to
    $0.0001
    per share. In addition, the Series D Preferred Stock will be entitled to participate with the common stock on an as-converted basis with respect to any dividends or other distributions to holders of common stock. There were
    no
    dividends declared as of
    December 
    31,
    2018
    or
    2017.
     
    Unless
    and until converted into common stock in accordance with its terms, the Series D Preferred Stock has
    no
    voting rights, other than as required by law or with respect to matters specifically affecting the Series D Preferred Stock.
    The Series D Preferred Stock is classified as permanent equity, as the Company controls all actions or events required to settle the optional conversion feature in shares.
     
    The
    August 2017
    Vivo Cash Warrants and
    August 2017
    Vivo Dilution Warrants are freestanding derivative instruments in connection with the issuance of equity instruments, which have been recorded as derivative liabilities. These warrants were recognized at their initial fair value upon issuance of
    $13.0
    million as determined by management with the assistance of an independent
    third
    party appraisal based on level
    3
    inputs. Changes in the fair value of these derivative liabilities from the date of issuance through
    December 
    31,
    2018
    have been recorded in earnings, with losses of
    $7.7
    million and
    $3.0
    million recorded for the years ended
    December 
    31,
    2018
    and
    2017,
    respectively. The remaining
    $12.0
    million of the
    $25.0
    million in gross proceeds received was allocated on a relative fair value basis, resulting in
    $5.6
    million of proceeds, net of
    $0.2
    million in issuance costs being allocated to the common stock sold in the
    August 2017
    Vivo Offering and
    $6.2
    million allocated to the Series D Preferred Stock. The Series D Preferred Stock includes a beneficial conversion feature of
    $5.8
    million as the full fair value of the Series D Preferred Stock of
    $12.0
    million was greater than the
    $6.2
    million allocated to the Series D Preferred Stock. The
    $5.8
    million beneficial conversation feature was recorded as a reduction to Additional Paid in Capital and a deemed dividend increasing net loss attributable to Amyris, Inc. common stockholders upon conversion in the
    third
    quarter of
    2017.
     
    At
    December 31, 2018
    and
    2017,
    8,280
    and
    12,958
    shares, respectively of Series D Preferred Stock were outstanding. In the
    third
    quarter of
    2018
    Vivo converted
    4,678
    shares of
    August 2017
    Offerings Series D Preferred Stock and the Company recognized a
    $6.8
    million deemed dividend for the unamortized discounts created from the allocation of proceeds, as a reduction to Additional Paid in Capital and increasing net loss attributable to Amyris, Inc. common stockholders.
     
    In the event of a Fundamental Transaction, the holders of the Series D Preferred Stock will have the right to receive the consider
    ation receivable as a result of such Fundamental Transaction by a holder of the number of shares of common stock for which the Series D Preferred Stock is convertible immediately prior to such Fundamental Transaction (without regard to whether such Series D Preferred Stock is convertible at such time), which amount shall be paid
    pari passu
    with all holders of common stock. A Fundamental Transaction is defined in the Certificate of Designation of Preferences, Rights and Limitations relating to the Series D Preferred Stock as any of the following: (i) merger with or consolidation into another legal entity; (ii) sale, lease, license, assignment, transfer or other disposition of all or substantially all of the Company’s assets in
    one
    or a series of related transactions; (iii) purchase offer, tender offer or exchange offer of the Company’s common stock pursuant to which holders of the Company’s common stock are permitted to sell, tender or exchange their shares for other securities, cash or property and has been accepted by the holders of
    50%
    or more of the outstanding common stock; (iv) reclassification, reorganization or recapitalization of the Company’s stock; or (v) stock or share purchase agreement that results in another party acquiring more than
    50%
    of the Company’s outstanding shares of common stock.
     
    Upon any liquidation, dissolution or winding-up of the Company, the holders of the Series D Preferred Stock shall be entitled to receive out of the assets of the Company the same amount that a holder of common stock would receive if the Series D Preferred Stock were fully converted to common stock immediately prior to such liquidation, dissolution or winding-up (without regard to whether such Series D Preferred Stock is convertible at such time), which amount shall be paid pari passu with all holders of common stock.
     
    The conversion of the Series D Preferred Stock is subject to a beneficial ownership limitation of
    9.99%
    (
    August 2017
    Vivo Offering Beneficial Ownership Limitation), which limitation
    may
    be waived by the holders on
    61
    days’ prior notice.
     
    The exercise price of the
    August 2017
    Vivo Cash Warrants is subject to standard adjustments as well as full-ratchet anti-dilution protection for any issuance by the Company of equity or equity-linked securities during the
    three
    -year period following
    August 3, 2017 (
    Vivo Dilution Period) at a per share price less than the then-current exercise price of the
    August 2017
    Vivo Cash Warrants, subject to certain exceptions. In connection with the entry by the Company and Vivo into warrant exercise agreements in
    August 2018
    and related transactions (see
    “August 2018
    Warrant Transactions” above), the Company and Vivo amended the
    August 2017
    Vivo Cash Warrants to (i) reduce the exercise price of such warrants from
    $6.39
    per share to
    $4.40
    per share and (ii) remove the
    August 2017
    Vivo Offering Beneficial Ownership Limitation from such warrants.
     
    The
    August 2017
    Vivo Dilution Warrants allow Vivo to purchase a number of shares of common stock sufficient to provide Vivo with full-ratchet anti-dilution protection for any issuance by the Company of equity or equity-linked securities during the Vivo Dilution Period at a per share price less than
    $4.26,
    the effective per share price paid by Vivo for the shares of common stock issuable upon conversion of the Series D Preferred Stock, subject to certain exceptions and subject to the Dilution Floor. The
    August 2017
    Vivo Dilution Warrants expire
    five
    years from the date they are initially exercisable.
     
    As of
    December 31, 2017,
    none
    of the
    August 2017
    Vivo Warrants were exercised. As of
    December 
    31,
    2018,
    5,575,118
    of the
    August 2017
    Vivo Cash Warrants had been exercised and the
    August 2017
    Vivo Dilution Warrants were
    not
    exercisable for any shares upon cancellation as part of the
    August 2018
    transaction. See
    “August 2018
    Warrant Transactions” above regarding the exercise of the
    August 2017
    Vivo Cash Warrants and the cancellation of the
    August 2017
    Vivo Dilution Warrants.
     
    In connection with the
    August 2017
    Vivo Offering, the Company agreed that it would
    not
    issue any shares of common stock or securities convertible into or exercisable or exchangeable for common stock at a price below the Dilution Floor without Vivo's consent.
     
    In connection with the
    August 2017
    Vivo Offering, the Company and Vivo also entered into a Stockholder Agreement (Vivo Stockholder Agreement) setting forth certain rights and obligations of Vivo and the Company. Pursuant to the Vivo Stockholder Agreement, Vivo will have the right, subject to certain restrictions and a minimum beneficial ownership level of
    4.5%,
    to (i) designate
    one
    director selected by Vivo to the Board and (ii) appoint
    a representative to attend all Board meetings in a nonvoting observer capacity and to receive copies of all materials provided to directors, subject to certain exceptions
    . Furthermore, Vivo will have the right to purchase additional shares of capital stock of the Company in connection with a sale of equity or equity-linked securities by the Company in a capital raising transaction for cash, subject to certain exceptions, to maintain its proportionate ownership percentage in the Company. Vivo agreed
    not
    to sell or transfer any of the shares of common stock, Series D Preferred Stock or warrants purchased by Vivo in the
    August 2017
    Vivo Offering, or any shares of common stock issuable upon conversion or exercise thereof, other than to its affiliates, without the consent of the Company through
    August 2018
    and to any
    competitor of the Company thereafter
    .
    Vivo also agreed that, subject to certain exceptions, until the later of (i)
    three
    years from the closing of the
    August 2017
    Vivo Offering and (ii)
    three
    months after there is
    no
    Vivo director on the Board, Vivo will
    not,
    without the prior consent of the Board, acquire common stock or rights to acquire common stock that would result in Vivo beneficially owning more than
    33%
    of the Company’s outstanding voting securities at the time of acquisition. Under the Vivo Stockholder Agreement, the Company agreed to use its commercially reasonable efforts to register, via
    one
    or more registration statements filed with the SEC under the Securities Act, the shares of common stock purchased in the
    August 2017
    Vivo Offering as well as the shares of common stock issuable upon conversion or exercise of the Series D Preferred Stock and warrants purchased by Vivo in the
    August 2017
    Vivo Offering.
     
    May 2017
    Exchange
    of Common Stock for Series C Convertible Preferred Stock - Related Party
     
    In
    May 2017,
    Foris and Naxyris agreed to exchange (
    May 2017
    Exchange) their outstanding shares of common stock, representing a total of
    1,394,706
    shares, for
    20,921
    shares of the Company's Series C Convertible Preferred Stock, par value
    $0.0001
    per share (Series C Preferred Stock) in a private exchange.
     
    Each share of Series C Preferred Stock had a stated value of
    $1,000
    and would automatically convert into common stock, at a conversion price of
    $15.00
    per share (Series C Conversion Rate), upon the approval by the Company's stockholders and implementation of a reverse stock split.
     
    The shares of Series C Preferred Stock automatically converted to common stock on
    June 6, 2017
    in connection with the
    effectiveness of the Reverse Stock Split. The Company accounted for the Series C Preferred Stock and the
    May 2017
    Exchange as a non-monetary transaction that had
    no
    impact on the consolidated financial statements.
     
    July 2015
    PIPE Warrants
     
    In
    July 2015,
    the Company entered into a securities purchase agreement with certain purchasers, including entities affiliated with members of the Board, under which the Company agreed to sell
    1,068,379
    shares of common stock at a price of
    $23.40
    per share, for aggregate proceeds to the Company of
    $25.0
    million. In connection with the sale, the Company granted to each of the purchasers a warrant, exercisable at a price of
    $0.15
    per share, to purchase of a number of shares of common stock equal to
    10%
    of the shares of common stock purchased by such investor. As of
    December 
    31,
    2018
    and
    2017,
    such warrants had been exercised with respect to
    25,643
    shares of common stock and warrants with respect to
    81,197
    shares of common stock were outstanding.
     
    For information regarding issuances of equity securities subsequent to
    December 
    31,
    2018,
    see Part II, Item
    8,
    “Subsequent Events”.
     
    Right of First Investment to Certain Investors
     
    In connection with investments in the Company has granted certain investors, including Vivo and DSM, a right of
    first
    investment if the Company proposes to sell securities in certain financing transactions. With these rights, such investors
    may
    subscribe for a portion of any such new financing and require the Company to comply with certain notice periods, which could discourage other investors from participating in, or cause delays in its ability to close, such a financing.
    XML 75 R12.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 3 - Balance Sheet Details
    12 Months Ended
    Dec. 31, 2018
    Notes to Financial Statements  
    Supplemental Balance Sheet Disclosures [Text Block]
    3.
    Balance Sheet Details
     
    Allowance for Doubtful Accounts
     
     
    Allowance for doubtful accounts activity and balances were as follows:
     
    (In thousands)
      Balance at
    Beginning of Year
      Provisions   Recoveries
    (Write-offs), Net
      Balance at
    End of Year
    Allowance for doubtful accounts:                                
    Year Ended December 31, 2018   $
    642
        $
        $     $
    642
     
    Year Ended December 31, 2017 (as restated, Note 2)   $
    501
        $
    141
        $     $
    642
     
     
    Inventories
     
    December 31,
    (In thousands)
      2018   2017
               
    (As Restated, Note 2)
    Raw materials   $
    3,901
        $
    819
     
    Work in process    
    539
         
    364
     
    Finished goods    
    5,253
         
    4,225
     
    Total inventories   $
    9,693
        $
    5,408
     
     
    Prepaid expenses and other current assets
     
    December 31,
    (In thousands)
      2018   2017
               
    (As Restated, Note 2)
    Prepayments, advances and deposits   $
    5,644
        $
    3,599
     
    Recoverable taxes from Brazilian government entities    
    631
         
    87
     
    Other    
    4,291
         
    1,233
     
    Total prepaid expenses and other current assets   $
    10,566
        $
    4,919
     
     
    Property, plant and equipment, net
     
    December 31,
    (In thousands)
      2018   2017
            (As Restated, Note 2)
    Machinery and equipment   $
    43,713
        $
    46,317
     
    Leasehold improvements    
    39,922
         
    40,036
     
    Computers and software    
    9,987
         
    9,555
     
    Furniture and office equipment, vehicles and land    
    3,016
         
    3,415
     
    Construction in progress    
    1,749
         
    2,838
     
    Total property, plant and equipment, gross    
    98,387
         
    102,161
     
    Less: accumulated depreciation and amortization    
    (78,631
    )    
    (88,269
    )
    Total property, plant and equipment, net   $
    19,756
        $
    13,892
     
     
    Property, plant and equipment, net includes
    $5.0
    million and
    $4.2
    million of machinery and equipment under capital leases as of
    December 
    31,
    2018
    and
    2017,
    respectively. Accumulated amortization of assets under capital lease totaled
    $2.3
    million and
    $1.6
    million as of
    December 
    31,
    2018
    and
    2017,
    respectively.
     
    Depreciation and amortization expense, including amortization of assets under capital leases, was
    $4.9
    million and
    $11.4
    million for the years ended
    December 
    31,
    2018
    and
    2017,
    respectively.
     
    Losses on disposal of property, plant and equipment were
    $0.9
    million and
    $0.1
    million for the years ended
    December 
    31,
    2018
    and
    2017,
    respectively. Such losses or gains were included in "Research and development" expense in the consolidated statements of operations.
     
    In
    December 2017,
    the Company's sold its Brotas production plant in Brazil to a unit of DSM Nutritional Products Ltd (together with its affiliates, DSM); see Note
    13,
    "Divestiture" and Note
    11,
    "Related Party Transactions" for details.
     
    Other assets
     
    December 31,
    (In thousands)
      2018   2017
            (As Restated, Note 2)
    Contingent consideration   $
    4,286
        $
    8,150
     
    Deposits    
    2,465
         
    2,462
     
    Other    
    1,207
         
    1,947
     
    Total other assets   $
    7,958
        $
    12,559
     
     
    Accrued and other current liabilities
     
    December 31,
    (In thousands)
      2018   2017
               
    (As Restated, Note 2)
    Payroll and related expenses   $
    9,220
        $
    7,238
     
    Contract termination fees    
    4,092
         
     
    Accrued interest    
    3,853
         
    8,213
     
    Asset retirement obligation
    (1)
       
    3,063
         
    3,587
     
    Ginkgo partnership payments obligation    
    2,155
         
     
    Tax-related liabilities    
    2,139
         
    5,837
     
    Professional services    
    1,173
         
    1,694
     
    Other    
    3,284
         
    2,633
     
    Total accrued and other current liabilities   $
    28,979
        $
    29,202
     
     
    ______________
     
    (
    1
    )
    The asset retirement obligation represents liabilities incurred but
    not
    yet discharged in connection with our
    2013
    abandonment of a partially constructed facility in Pradópolis, Brazil.
     
    Other noncurrent liabilities
     
    December 31,
    (In thousands)
      2018   2017
            (As Restated, Note 2)
    Liability for unrecognized tax benefit   $
    6,582
        $
    6,582
     
    Deferred rent, net of current portion    
    6,440
         
    7,818
     
    Ginkgo partnership payments obligation, net of current portion    
    6,185
         
    6,444
     
    Contract liabilities, net of current portion    
    1,587
         
    383
     
    Contract termination fees, net of current portion
    (1)
       
    1,530
         
     
    Capital leases, net of current portion    
    195
         
    217
     
    Other    
    673
         
    2,214
     
    Total other noncurrent liabilities   $
    23,192
        $
    23,658
     
    ______________
     
    (
    1
    )
    Contract liabilities, net of current portion at
    December 31, 2018
    and
    2017
    includes
    $1,204
    and
    $383
    in connection with DSM, which is a related party.
     
    In
    November 2017,
    the Company entered into a partnership agreement with
    one
    of its former collaboration partners, Ginkgo Bioworks, Inc. and has an obligation to make quarterly payments of
    $0.8
    million from
    December 31, 2018
    through
    September 2022.
    At
    December 31, 2018,
    total future minimum payments under the agreement totaled
    $12.7
    million. The Company recorded this liability at its discounted present value of
    $6.1
    million and is accreting the
    $6.6
    million discount to interest expense over the
    five
    -year repayment period. Also, in conjunction with the partnership agreement, the Company issued a
    $12.0
    million promissory note, which is included in long-term debt at a
    $8.0
    million carrying value, net of unamortized discount. See Note
    10,
    “Revenue Recognition” for information regarding the Ginkgo Partnership Agreement and the related accounting treatment for the partnership payments.
     
    In
    September 2019,
    the Company was notified by DSM that certain contingent consideration payable to the Company upon the realization of certain NOL tax benefits transferred to DSM with the sale of the Brotas facility in
    December 2017
    would
    not
    be realized due to changes in DSM’s Brazilian legal entity structure. The Company considered this information in conjunction with the probability and timing of DSM’s realization of the underlying NOL tax benefits and determined that
    $3.9
    million of the contingent consideration receivable was
    not
    recoverable as of
    December 31, 2018.
    XML 76 R83.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 12 - Stock-based Compensation (Details Textual) - USD ($)
    1 Months Ended 12 Months Ended
    Sep. 28, 2010
    May 31, 2018
    Dec. 31, 2018
    Dec. 31, 2017
    Dec. 31, 2005
    Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number, Ending Balance     5,390,270 1,338,367  
    Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance     $ 11.55 $ 33.40  
    Performance-based Stock Options, Grant Date Fair Value     $ 5,100,000    
    Share-based Payment Arrangement, Expense     9,190,000 $ 6,265,000  
    Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value     $ 200,000 0  
    Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period     70,807    
    Chief Executive Officer [Member]          
    Purchasable Shares Under Performance Based Options   3,250,000      
    Performance-Based Stock Options, Exercise Price     $ 5.08    
    Performance-based Stock Options [Member]          
    Performance-Based Stock Options, Exercise Price     $ 5.08    
    Share-based Payment Arrangement, Expense     $ 700,000    
    Share-based Payment Arrangement, Option [Member]          
    Share-based Payment Arrangement, Expense     $ 2,600,000 3,300,000  
    Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition     3 years 292 days    
    Restricted Stock Units (RSUs) [Member]          
    Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period     5,452,664    
    Share-based Payment Arrangement, Expense     $ 6,400,000 2,800,000  
    Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value     $ 5,452,664 $ 523,167  
    Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value     $ 5.36 $ 5.51  
    Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total     $ 23,800,000 $ 5,000,000  
    Minimum [Member] | Chief Executive Officer [Member]          
    Performance-Based Stock Options Contingently Available for Issuance     0    
    Maximum [Member] | Chief Executive Officer [Member]          
    Performance-Based Stock Options Contingently Available for Issuance     3,250,000    
    Equity Incentive Plan, 2010 [Member]          
    Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized 2,000,000        
    Share-based Compensation Arrangement by Share-based Payment Award, Options, Period Available to Grant 10 years        
    Share-based Compensation Arrangement by Share-based Payment Award, Minimum Percent of Execrise Price to Fair Market Value on Grant Date 100.00%        
    Share-based Compensation Arrangement by Share-based Payment Award, Minimum Percent of Shareholder Triggering Higher Exercise Price 10.00%        
    Share-based Compensation Arrangement by Share-based Payment Award, Minimum Percent of Execrise Price to Fair Market Value on Grant Date of Ten Percent or Greater Shareholder of Company 110.00%        
    Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number, Ending Balance     5,339,214 1,255,045  
    Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance     $ 33.40 $ 26.29  
    Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant   9,280,000 2,359,750 252,107  
    Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized   9,000,000      
    Share-based Compensation Arrangement by Share-based Payment Award, Maximum Number of Shares Per Employee   4,000,000      
    Equity Incentive Plan, 2010 [Member] | Restricted Stock [Member]          
    Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period     5,294,803 683,554  
    Equity Incentive Plan, 2010 [Member] | Minimum [Member]          
    Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period 3 years        
    Equity Incentive Plan, 2010 [Member] | Maximum [Member]          
    Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period 5 years        
    Stock Options and Stock Issuance Plans, 2005 [Member]          
    Share-based Compensation Arrangement by Share-based Payment Award, Options, Period Available to Grant         10 years
    Share-based Compensation Arrangement by Share-based Payment Award, Minimum Percent of Execrise Price to Fair Market Value on Grant Date         100.00%
    Share-based Compensation Arrangement by Share-based Payment Award, Minimum Percent of Shareholder Triggering Higher Exercise Price         10.00%
    Share-based Compensation Arrangement by Share-based Payment Award, Minimum Percent of Execrise Price to Fair Market Value on Grant Date of Ten Percent or Greater Shareholder of Company         110.00%
    Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period         5 years
    Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number, Ending Balance     52,389 79,322  
    Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance     $ 185.93 $ 144.58  
    Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant     0    
    Employee Stock Purchase Plan, 2010 [Member]          
    Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized   1,666,666      
    Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant     382,824 80,594  
    Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized   1,000,000      
    Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent 85.00%        
    Shares Available for Issuance, Percentage of Total Outstanding Shares 1.00%        
    Share-based Payment Arrangement, Expense     $ 200,000 $ 100,000  
    Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period     246,230 47,058  
    XML 77 R73.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 10 - Revenue Recognition - Disaggregation of Revenue (Details) - USD ($)
    $ in Thousands
    12 Months Ended
    Dec. 31, 2018
    Dec. 31, 2017
    Revenues $ 63,604 $ 127,671
    Product [Member]    
    Revenues 33,598 42,370
    Europe [Member]    
    Revenues   23,823
    Europe [Member] | Product [Member]    
    Revenues 29,405  
    UNITED STATES    
    Revenues 26,241 78,286
    Asia [Member]    
    Revenues 6,331 23,290
    BRAZIL    
    Revenues 942 2,159
    Other Area [Member]    
    Revenues $ 685 $ 113
    XML 78 R77.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 10 - Revenue Recognition - Remaining Performance Obligations 2 (Details)
    $ in Thousands
    Dec. 31, 2018
    USD ($)
    Revenue, Remaining Performance Obligation, Amount $ 22,056
    Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2019-01-01  
    Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period 1 year
    Revenue, Remaining Performance Obligation, Amount $ 14,131
    Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2020-01-01  
    Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period 1 year
    Revenue, Remaining Performance Obligation, Amount $ 7,925
    Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2021-01-01  
    Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period 1 year
    Revenue, Remaining Performance Obligation, Amount
    Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2022-01-01  
    Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period 1 year
    Revenue, Remaining Performance Obligation, Amount
    XML 79 R87.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 12 - Stock-based Compensation - Share-based Payment Award, Stock Options, Valuation Assumptions (Details) - Share-based Payment Arrangement, Option [Member]
    12 Months Ended
    Dec. 31, 2018
    Dec. 31, 2017
    Expected dividend yield
    Risk-free interest rate 2.80% 2.10%
    Expected term (in years) (Year) 6 years 328 days 6 years 43 days
    Expected volatility 80.00% 84.00%
    XML 80 R54.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 4 - Fair Value Measurement - Fair Value, Assets, and Liabilities Measured on Recurring Basis (Details) - USD ($)
    $ in Thousands
    Dec. 31, 2018
    Dec. 31, 2017
    Debt, current portion, fair value $ 57,918 $ 0
    Fair Value, Recurring [Member]    
    Total assets measured and recorded at fair value 57,352
    Debt, current portion, fair value 57,918
    Embedded derivatives in connection with the issuance of debt and equity instruments 723
    Freestanding derivative instruments in connection with the issuance of equity instruments 42,796 115,774
    Total liabilities measured and recorded at fair value 100,714 116,497
    Fair Value, Recurring [Member] | Money Market Funds [Member]    
    Cash equivalents 53,199
    Fair Value, Recurring [Member] | Certificates of Deposit [Member]    
    Cash equivalents 4,153
    Fair Value, Inputs, Level 1 [Member] | Fair Value, Recurring [Member]    
    Total assets measured and recorded at fair value 53,199
    Debt, current portion, fair value
    Embedded derivatives in connection with the issuance of debt and equity instruments
    Freestanding derivative instruments in connection with the issuance of equity instruments
    Total liabilities measured and recorded at fair value
    Fair Value, Inputs, Level 1 [Member] | Fair Value, Recurring [Member] | Money Market Funds [Member]    
    Cash equivalents 53,199
    Fair Value, Inputs, Level 1 [Member] | Fair Value, Recurring [Member] | Certificates of Deposit [Member]    
    Cash equivalents
    Fair Value, Inputs, Level 2 [Member] | Fair Value, Recurring [Member]    
    Total assets measured and recorded at fair value 4,153
    Debt, current portion, fair value
    Embedded derivatives in connection with the issuance of debt and equity instruments
    Freestanding derivative instruments in connection with the issuance of equity instruments
    Total liabilities measured and recorded at fair value
    Fair Value, Inputs, Level 2 [Member] | Fair Value, Recurring [Member] | Money Market Funds [Member]    
    Cash equivalents
    Fair Value, Inputs, Level 2 [Member] | Fair Value, Recurring [Member] | Certificates of Deposit [Member]    
    Cash equivalents 4,153
    Fair Value, Inputs, Level 3 [Member] | Fair Value, Recurring [Member]    
    Total assets measured and recorded at fair value
    Debt, current portion, fair value 57,918
    Embedded derivatives in connection with the issuance of debt and equity instruments 723
    Freestanding derivative instruments in connection with the issuance of equity instruments 42,796 115,774
    Total liabilities measured and recorded at fair value 100,714 116,497
    Fair Value, Inputs, Level 3 [Member] | Fair Value, Recurring [Member] | Money Market Funds [Member]    
    Cash equivalents
    Fair Value, Inputs, Level 3 [Member] | Fair Value, Recurring [Member] | Certificates of Deposit [Member]    
    Cash equivalents
    XML 81 R50.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 3 - Balance Sheet Details - Other Assets (Details) - USD ($)
    $ in Thousands
    Dec. 31, 2018
    Dec. 31, 2017
    Contingent consideration $ 4,286 $ 8,150
    Deposits 2,465 2,462
    Other 1,207 1,947
    Total other assets $ 7,958 $ 12,559 [1]
    [1] Correction of error in recording amounts payable under Ginkgo Partnership Agreement as prepaid royalties instead of reduction in revenue.
    XML 82 R58.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 4 - Fair Value Measurement - Market-based Assumption and Estimates for Compound Embedded Derivative Liabilities Valuation (Details)
    12 Months Ended
    Dec. 31, 2018
    $ / shares
    Dec. 31, 2017
    $ / shares
    Share Price $ 3.34 $ 3.75
    Measurement Input, Probability of Change in Control [Member]    
    Derivative liabilities, measurement input 0 0.05
    Minimum [Member]    
    Estimated conversion dates 2019 2018
    Minimum [Member] | Measurement Input, Risk Free Interest Rate [Member]    
    Derivative liabilities, measurement input 0.025 0.017
    Minimum [Member] | Measurement Input, Risk-adjusted Yields [Member]    
    Derivative liabilities, measurement input 0.172 0.184
    Minimum [Member] | Measurement Input, Price Volatility [Member]    
    Derivative liabilities, measurement input 0.45 0.45
    Minimum [Member] | Measurement Input, Credit Spread [Member]    
    Derivative liabilities, measurement input 0.146 0.166
    Maximum [Member]    
    Estimated conversion dates 2025 2025
    Maximum [Member] | Measurement Input, Risk Free Interest Rate [Member]    
    Derivative liabilities, measurement input 0.03 0.024
    Maximum [Member] | Measurement Input, Risk-adjusted Yields [Member]    
    Derivative liabilities, measurement input 0.273 0.285
    Maximum [Member] | Measurement Input, Price Volatility [Member]    
    Derivative liabilities, measurement input 0.85 0.8
    Maximum [Member] | Measurement Input, Credit Spread [Member]    
    Derivative liabilities, measurement input 0.249 0.267
    XML 83 R96.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 14 - Income Taxes - Activity in the Deferred Tax Assets Valuation Allowance (Details) - USD ($)
    $ in Thousands
    12 Months Ended
    Dec. 31, 2018
    Dec. 31, 2017
    Balance at Beginning of Year $ 81,086 $ 386,867
    Additions 42,939
    Reductions/Charges (305,781)
    Balance at End of Year $ 124,025 $ 81,086
    XML 84 R66.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 7 - Stockholders' Deficit - Number of Callable Shares (Details)
    12 Months Ended
    Dec. 31, 2018
    Convertible Senior Notes, 6.0% Due in 2021 [Member]  
    Number of shares into which debt instrument is convertible 9,493,672
    The 2015 144A Notes [Member]  
    Number of shares into which debt instrument is convertible 2,338,560
    August 2013 Convertible Notes [Member]  
    Number of shares into which debt instrument is convertible 1,003,554
    The 2014 144A Notes [Member]  
    Number of shares into which debt instrument is convertible 867,376
    Convertible Notes [Member]  
    Number of shares into which debt instrument is convertible 13,703,162
    XML 85 R62.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 5 - Debt - Long-term Debt Instruments (Details)
    $ in Thousands
    Dec. 31, 2018
    USD ($)
    2019 $ 172,595
    2020 12,481
    2021 62,261
    2022 13,417
    2023 367
    Thereafter 2,200
    Total future minimum payments 263,321
    Less: amount representing interest(1) (33,706) [1]
    Less: future conversion of accrued interest to principal (694)
    Present value of minimum debt payments 228,921
    Less: current portion of debt principal (154,840)
    Noncurrent portion of debt principal 74,081
    Convertible Debt [Member]  
    2019 134,368
    2020
    2021
    2022
    2023
    Thereafter
    Total future minimum payments 134,368
    Less: amount representing interest(1) (7,368) [1]
    Less: future conversion of accrued interest to principal (694)
    Present value of minimum debt payments 126,306
    Less: current portion of debt principal (126,306)
    Noncurrent portion of debt principal
    Loans Payable and Credit Facilities [Member]  
    2019 10,219
    2020 9,981
    2021 34,740
    2022 13,417
    2023 367
    Thereafter 2,200
    Total future minimum payments 70,924
    Less: amount representing interest(1) (18,014) [1]
    Less: future conversion of accrued interest to principal
    Present value of minimum debt payments 52,910
    Less: current portion of debt principal (3,829)
    Noncurrent portion of debt principal 49,081
    Related Party Convertible Notes [Member]  
    2019 25,508
    2020
    2021
    2022
    2023
    Thereafter
    Total future minimum payments 25,508
    Less: amount representing interest(1) (803) [1]
    Less: future conversion of accrued interest to principal
    Present value of minimum debt payments 24,705
    Less: current portion of debt principal (24,705)
    Noncurrent portion of debt principal
    Related Party Loans Payable and Credit Facilities [Member]  
    2019 2,500
    2020 2,500
    2021 27,521
    2022
    2023
    Thereafter
    Total future minimum payments 32,521
    Less: amount representing interest(1) (7,521) [1]
    Less: future conversion of accrued interest to principal
    Present value of minimum debt payments 25,000
    Less: current portion of debt principal
    Noncurrent portion of debt principal $ 25,000
    [1] Excluding net debt discount of $17.1 million that will be amortized to interest expense over the term of the debt.
    XML 86 R92.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 14 - Income Taxes - Components of Income Loss (Details) - USD ($)
    $ in Thousands
    12 Months Ended
    Dec. 31, 2018
    Dec. 31, 2017
    United States $ (218,109) $ (156,020)
    Foreign (12,125) 6,915
    Loss before income taxes $ (230,234) $ (149,105)
    XML 87 R9.htm IDEA: XBRL DOCUMENT v3.19.3
    Consolidated Statements of Cash Flows - USD ($)
    $ in Thousands
    12 Months Ended
    Dec. 31, 2018
    Dec. 31, 2017
    Operating activities    
    Net loss $ (230,235) $ (155,982)
    Adjustments to reconcile net loss to net cash used in operating activities:    
    Loss from change in fair value of derivative liabilities 30,880 48,852
    Loss upon conversion or extinguishment of debt 17,424 11,897
    Amortization of debt discount 16,602 15,239
    Stock-based compensation 9,190 6,265
    Modification of warrants recorded as legal expense 6,764
    Depreciation and amortization 4,921 11,358
    Issuance costs on warrant exercises for cash 4,389
    Impairment of other assets 3,865
    Debt issuance costs expensed due to fair value option 3,810
    Loss (gain) on divestiture 1,778 (5,732)
    Loss on disposal of property, plant and equipment 941 142
    Gain on foreign currency exchange rates (2,223) (1,230)
    Gain from change in fair value of debt (2,082)
    Noncash revenue reduction related to issuance of debt obligations under Ginkgo Partnership Agreement 13,413
    Receipt of noncash consideration in connection with license revenue (8,046)
    Changes in assets and liabilities:    
    Accounts receivable 7,448 (19,647)
    Accounts receivable, unbilled – related party 8,056 (7,940)
    Inventories (4,416) (3,126)
    Deferred cost of products sold (3,317)
    Prepaid expenses and other assets (6,383) (18,730)
    Accounts payable 11,603 5,452
    Accrued and other liabilities 8,461 13,877
    Contract liabilities 3,158 (7,241)
    Net cash used in operating activities (109,366) (101,179)
    Investing activities    
    Purchases of property, plant and equipment (12,472) (4,412)
    Proceeds from divestiture, net of cash transferred 54,827
    Maturities of short-term investments 12,403
    Sale of short-term investments 676
    Purchase of short-term investments (11,786)
    Net cash (used in) provided by investing activities (12,472) 51,708
    Financing activities    
    Proceeds from issuance of debt, net of issuance costs 94,371 18,925
    Proceeds from exercise of warrants, net of issuance costs 57,767
    Proceeds from issuance of common stock in private placements, net of issuance costs 1,415
    Proceeds from ESPP purchases 777
    Proceeds from exercises of common stock options 288
    Principal payments on debt (41,668) (37,500)
    Debt issuance costs incurred in connection with debt instrument accounted at fair value (3,752)
    Principal payments on capital leases (981)
    Payment of minimum employee taxes withheld upon net share settlement of restricted stock units (260) (385)
    Proceeds from issuance of convertible preferred stock 98,246
    Proceeds from issuance of common stock in August 2017 offering 5,759
    Issuance costs incurred (2,159)
    Payment of swap termination (3,113)
    Payment on early redemption of debt (1,909)
    Net cash provided by financing activities 107,957 77,864
    Effect of exchange rate changes on cash, cash equivalents and restricted cash (77) 186
    Net (decrease) increase in cash, cash equivalents and restricted cash (13,958) 28,579
    Cash, cash equivalents and restricted cash at beginning of year 61,012 32,433
    Cash, cash equivalents and restricted cash at end of year 47,054 61,012
    Cash and cash equivalents 45,353 57,059
    Restricted cash, current 741 2,994
    Restricted cash, noncurrent 960 959
    Supplemental disclosures of cash flow information:    
    Cash paid for interest 18,524 11,539
    Supplemental disclosures of non-cash investing and financing activities:    
    Derecognition of derivative liabilities upon exercise of warrants 108,670
    Issuance of common stock upon conversion of convertible notes 24,970 28,702
    Issuance of common stock - related party 6,050
    Accrued interest added to debt principal 3,664 2,816
    Issuance of common stock for settlement of debt principal and interest payments 1,800 3,436
    Cumulative effect adjustment of ASC 606 762
    Financing of insurance premium under note payable 495 467
    Financing of equipment under financing leases 271
    Issuance of preferred stock attributed to derivative liabilities 72,725
    Issuance of convertible preferred stock upon conversion of debt 40,204
    Settlement of debt principal by a related party 25,000
    Issuance of note payable in exchange for debt extinguishment with third party 16,954
    Issuance of common stock for settlement of debt $ 10,708
    XML 88 R49.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 3 - Balance Sheet Details - Property, Plant and Equipment (Details) - USD ($)
    $ in Thousands
    Dec. 31, 2018
    Dec. 31, 2017
    Property, plant and equipment $ 98,387 $ 102,161
    Less: accumulated depreciation and amortization (78,631) (88,269)
    Total property, plant and equipment, net 19,756 13,892
    Machinery and Equipment [Member]    
    Property, plant and equipment 43,713 46,317
    Leasehold Improvements [Member]    
    Property, plant and equipment 39,922 40,036
    Computer Equipment and Software [Member]    
    Property, plant and equipment 9,987 9,555
    Furniture and Office Equipment, Vehicles and Land [Member]    
    Property, plant and equipment 3,016 3,415
    Construction in Progress [Member]    
    Property, plant and equipment $ 1,749 $ 2,838
    XML 89 R5.htm IDEA: XBRL DOCUMENT v3.19.3
    Consolidated Statements of Operations (Parentheticals) - USD ($)
    $ in Thousands
    12 Months Ended
    Dec. 31, 2018
    Dec. 31, 2017
    Revenues, related party $ 1,053 $ 60,942
    Product [Member]    
    Revenues, related party 360 1,291
    Licenses and Royalties [Member]    
    Revenues, related party 5,958 57,972
    Grants and Collaborations [Member]    
    Revenues, related party $ 4,735 $ 1,679
    XML 90 R41.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 1 - Basis of Presentation and Summary of Significant Accounting Policies - Concentration of Credit Risk (Details) - Customer Concentration Risk [Member]
    12 Months Ended
    Dec. 31, 2018
    Dec. 31, 2017
    Accounts Receivable [Member] | Customer B [Member]    
    Concentration risk percentage 24.00% 10.00%
    Accounts Receivable [Member] | Customer A [Member]    
    Concentration risk percentage [1] 38.00%
    Accounts Receivable [Member] | Customer C [Member]    
    Concentration risk percentage 19.00% 15.00%
    Accounts Receivable [Member] | Customer G [Member]    
    Concentration risk percentage 11.00% [1]
    Revenues [Member] | Customer B [Member]    
    Concentration risk percentage 18.00% 13.00%
    Revenues [Member] | Customer A [Member]    
    Concentration risk percentage 17.00% 46.00%
    Revenues [Member] | Customer C [Member]    
    Concentration risk percentage 13.00% [2]
    Revenues [Member] | Customer D [Member]    
    Concentration risk percentage 13.00% [2]
    Revenues [Member] | Customer E [Member]    
    Concentration risk percentage [2] 11.00%
    Revenues [Member] | Customer F [Member]    
    Concentration risk percentage [2]
    [1] Less than 10%
    [2] Less than 10%
    XML 91 R45.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 3 - Balance Sheet Details (Details Textual) - USD ($)
    $ in Thousands
    1 Months Ended 12 Months Ended
    Nov. 30, 2017
    Dec. 31, 2018
    Dec. 31, 2017
    Property, Plant and Equipment, Net, Ending Balance   $ 19,756 $ 13,892
    Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance   78,631 88,269
    Contract with Customer, Liability, Current [1],[2]   8,236 4,308 [3]
    Long-term Debt, Total   209,697 163,704
    Realization of Certain NOL Tax Benefits [Member]      
    Contingent Consideration Receivable   0 3,900
    Promissory Note for Partnership Agreement With Ginkgo Bioworks [Member]      
    Debt Instrument, Face Amount $ 12,000    
    Long-term Debt, Total 8,000    
    Partnership Agreement with Ginkgo Bioworks Inc. [Member]      
    Partnership Agreement, Quarterly Payment Amount $ 800    
    Contractual Obligation, Total   12,700  
    Contractual Obligation, Present Value   6,100  
    Contractual Obligation, Interest Payable   6,600  
    Contractual Obligation, Term 5 years    
    DSM International B.V. [Member]      
    Contract with Customer, Liability, Current   1,204 383
    Other Expense, Net [Member]      
    Gain (Loss) on Disposition of Property Plant Equipment, Excluding Oil and Gas Property and Timber Property   900 100
    Property, Plant and Equipment, Including Capital Leases [Member]      
    Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance   4,900 11,400
    Capital Lease Obligations [Member]      
    Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance   2,300 1,600
    Capital Lease Obligations [Member] | Machinery and Equipment, Furniture and Office Equipment Under Capital Lease [Member]      
    Property, Plant and Equipment, Net, Ending Balance   $ 5,000 $ 4,200
    [1] The balance in contract liabilities at December 31, 2017 represents deferred revenue, current prior to the Company's adoption of ASC 606, "Revenue".
    [2] The balance in contract liabilities, current at December 31, 2017 represents deferred revenue, current prior to the Company's adoption of ASC 606, "Revenue".
    [3] Revision to accounting for equity received in satisfaction of a customer receivable.
    XML 92 R1.htm IDEA: XBRL DOCUMENT v3.19.3
    Document And Entity Information - USD ($)
    $ in Millions
    12 Months Ended
    Dec. 31, 2018
    Sep. 26, 2019
    Jun. 28, 2019
    Document Information [Line Items]      
    Entity Registrant Name AMYRIS, INC.    
    Entity Central Index Key 0001365916    
    Trading Symbol amrs    
    Current Fiscal Year End Date --12-31    
    Entity Filer Category Accelerated Filer    
    Entity Current Reporting Status Yes    
    Entity Voluntary Filers No    
    Entity Well-known Seasoned Issuer No    
    Entity Emerging Growth Company false    
    Entity Small Business true    
    Entity Common Stock, Shares Outstanding (in shares)   103,400,207  
    Entity Public Float     $ 226.5
    Entity Shell Company false    
    Document Type 10-K/A    
    Document Period End Date Dec. 31, 2018    
    Document Fiscal Year Focus 2018    
    Document Fiscal Period Focus FY    
    Amendment Flag true    
    Amendment Description This Amendment No. 1 on Form 10-K/A (this “Amendment”) amends the Annual Report on Form 10-K of Amyris, Inc. (the “Company”) for the fiscal year ended December 31, 2018 (the “Form 10-K”), as filed with the Securities and Exchange Commission (the “SEC”) on October 1, 2019 (the “Original Filing Date”). This Amendment is being filed solely (i) for the purpose of furnishing Exhibit 101 (Interactive Data Files) to the Form 10-K, which was not included in the original filing of the Form 10-K with the SEC on the Original Filing Date, (ii) to correct administrative errors in the content of (A) the Report of Independent Registered Public Accounting Firm of BDO USA, LLP (the “BDO Report”), the Company’s independent registered public accounting firm for the fiscal year ended December 31, 2017, contained in Part II, Item 8 of the Form 10-K and (B) the Reports of Independent Registered Public Accounting Firm of Macias Gini & O’Connell LLP (the “MGO Reports”), the Company’s independent registered public accounting firm for the fiscal year ended December 31, 2018, contained in Part II, Item 8 and Part II, Item 9A of the Form 10-K, respectively and (iii) to correct certain other immaterial errors in Part II, Item 8 of the Form 10-K as set forth below. The BDO Report and MGO Reports in the Form 10-K incorrectly contained certain references to September 30, 2019, when the correct date was October 1, 2019. Accordingly, such reports have been updated to refer to the correct date. In addition, (i) certain references to “Contract assets” in the financial statement tables and related disclosure in Part II, Item 8 of the Form 10-K have been amended to refer to “Accounts receivable, unbilled – related party”, (ii) a line item for “Accounts receivable, unbilled, noncurrent - related party” has been added to the “Contract Balances” table in Note 10, “Revenue Recognition” in Part II, Item 8 of this Amendment, (iii) the amount of federal NOL and state NOL carryovers written off by the Company as a result of events occurring during the year ended December 31, 2017, disclosed in Note 14, “Income Taxes” in Part II, Item 8 of the Form 10-K, has been corrected, (iv) certain legend references and explanations in the tables in Note 2, “Restatement of 2017 Consolidated Financial Statements” and the “2017 and 2018 Quarterly Data – Restated Condensed Consolidated Financial Statements” section immediately after Note 16, “Subsequent Events” in Part II, Item 8 of the Form 10-K have been updated by deleting unused explanations, expanding or conforming certain explanations and adding certain explanations that were inadvertently excluded from such tables and (v) certain typographical errors in the financial statement tables and related disclosure in Part II, Item 8 of the Form 10-K have been corrected to conform to the correct disclosure provided elsewhere in Part II, Item 8 of the Form 10-K. No other changes have been made to the Form 10-K. This Amendment speaks as of the Original Filing Date and does not reflect events that may have occurred subsequent to the Original Filing Date, and, except as expressly set forth herein, does not modify or update in any way the disclosures made in the Form 10-K. Pursuant to Rule 12b-15 promulgated under the Securities Exchange Act of 1934, this Amendment sets forth the complete text of Part II, Item 8 and Part II, Item 9A of the Form 10-K as amended hereby. Part IV, Item 15 of this Amendment reflects (i) new consents of BDO USA, LLP and Macias Gini & O’Connell LLP, (ii) Exhibit 101 (Interactive Data Files) and (iii) new certifications pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 and Section 906 of the Sarbanes-Oxley Act of 2002, each of which is filed or furnished herewith, as applicable.    
    Title of 12(b) Security Common Stock    
    XML 93 R24.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 15 - Geographical Information
    12 Months Ended
    Dec. 31, 2018
    Notes to Financial Statements  
    Segment Reporting Disclosure [Text Block]
    15.
    Geographical Information
     
    The chief operating decision maker is the Company's Chief Executive Officer, who makes resource allocation decisions and assesses performance based on financial information presented on a consolidated basis. There are
    no
    segment managers who are held accountable by the chief operating decision maker, or anyone else, for operations, operating results, and planning for levels or components below the consolidated unit level. Accordingly, the Company has determined that it has a single reportable segment and operating segment structure.
     
    Revenue
     
    Revenue by geography, based on each customer's location, is shown in Note
    10,
    "Revenue Recognition".
     
    Property, Plant and Equipment
     
    December 31,
    (In thousands)
      2018   2017
               
    (As Restated, Note 2)
    United States   $
    13,111
        $
    10,357
     
    Brazil    
    6,447
         
    3,357
     
    Europe    
    198
         
    178
     
        $
    19,756
        $
    13,892
     
    XML 94 R20.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 11 - Related Party Transactions
    12 Months Ended
    Dec. 31, 2018
    Notes to Financial Statements  
    Related Party Transactions Disclosure [Text Block]
    11.
    Related Party Transactions
     
    Related Party Divestiture
     
    See Note
    13,
    “Divestiture” for details regarding the sale of Amyris Brasil to DSM in
    December 2017.
     
    Related Party Equity
     
    See Note
    7,
    "Stockholders' Deficit" for details of these related party equity transactions:
       
    November 2018
    DSM Securities Purchase Agreement
       
    August 2018
    Warrant Transactions
       
    August 2017
    DSM Offering
       
    May 2017
    Offerings
       
    May 2017
    Exchange of Common Stock for Series C Convertible Preferred Stock
       
    July 2015
    PIPE Warrants
       
    Temasek Funding Warrant
     
    Related Party Debt
     
    See Note
    5,
    "Debt" for details of these related party debt transactions:
       
    DSM Note (also see Note
    13,
    "Divestiture")
       
    February 2016
    Private Placement
       
    2014
    Rule
    144A
    Convertible Notes
       
    August 2013
    Financing Convertible Notes
       
    R&D Note
     
     
    Related party debt was as follows:
     
    December 31,

    (in thousands)
      2018   2017
        Principal   Unamortized
    Debt
    (Discount)
    Premium
      Net   Principal   Unamortized
    Debt
    (Discount)
    Premium
      Net
    Total                        
    2014 Rule 144A convertible notes   $
    9,705
        $
    (422
    )   $
    9,283
        $
    9,705
        $
    (1,538
    )   $
    8,167
     
    August 2013 financing convertible notes    
         
         
         
    21,711
         
    897
         
    22,608
     
    R&D note    
         
         
         
    3,700
         
    (18
    )    
    3,682
     
         
    9,705
         
    (422
    )    
    9,283
         
    35,116
         
    (659
    )    
    34,457
     
    DSM                                                
    DSM note    
    25,000
         
    (6,311
    )    
    18,689
         
    25,000
         
    (8,039
    )    
    16,961
     
    Other DSM loan    
         
         
         
    393
         
         
    393
     
         
    25,000
         
    (6,311
    )    
    18,689
         
    25,393
         
    (8,039
    )    
    17,354
     
    Biolding                                                
    February 2016 private placement    
         
         
         
    2,000
         
         
    2,000
     
                                                     
    Foris                                                
    2014 Rule 144A convertible notes    
    5,000
         
    (181
    )    
    4,819
         
    5,000
         
    (660
    )    
    4,340
     
                                                     
    Temasek                                                
    2014 Rule 144A convertible notes    
    10,000
         
    (435
    )    
    9,565
         
    10,000
         
    (1,591
    )    
    8,409
     
        $
    49,705
        $
    (7,349
    )   $
    42,356
        $
    77,509
        $
    (10,949
    )   $
    66,560
     
     
    The fair value of the derivative liabilities related to the related party R&D Note, related party
    August 2013
    Financing Convertible Notes (Tranche Notes) and related party
    2014
    Rule
    144A
    Convertible Notes as of
    December 
    31,
    2018
    and
    2017
    was
    $0
    and
    $0.2
    million, respectively. The Company recognized (losses) gains from change in the fair value of these derivative liabilities of (
    $8.5
    ) million and
    $0.6
    million for the years ended
    December 
    31,
    2018
    and
    2017,
    respectively; see Note
    4,
    "Fair Value Measurement".
     
    At
    December 
    31,
    2018,
    Temasek was
    no
    longer a related party. However, the Company and Temasek were related parties when they entered into the
    2014
    Rule
    144A
    convertible notes transaction, for which terms have remained unchanged since the borrowing date.
     
    Related Party Revenue
     
    The Company recognized revenue from related parties and from all other customers as follows:
     
    Years Ended December 31,
    (In thousands)
      2018   2017 (As restated, Note 2)
        Renewable Products   Licenses and Royalties   Grants and Collaborations   TOTAL   Renewable Products   Licenses and Royalties   Grants and Collaborations   TOTAL
    Revenue from related parties:                                                                
    DSM   $
    18
        $
    5,958
        $
    4,735
        $
    10,711
        $
        $
    57,972
        $
    1,679
        $
    59,651
     
    Total    
    342
         
         
         
    342
         
    (200
    )    
         
         
    (200
    )
    Novvi    
         
         
         
         
    1,491
         
         
         
    1,491
     
    Subtotal revenue from related parties    
    360
         
    5,958
         
    4,735
         
    11,053
         
    1,291
         
    57,972
         
    1,679
         
    60,942
     
    Revenue from all other customers
    (1)
       
    33,238
         
    1,700
         
    17,613
         
    52,551
         
    41,079
         
    (9,269
    )    
    34,919
         
    66,729
     
    Total revenue from all customers   $
    33,598
        $
    7,658
        $
    22,348
        $
    63,604
        $
    42,370
        $
    48,703
        $
    36,598
        $
    127,671
     
     
     
    (
    1
    )
    Licenses and royalties revenue is negative for
    2017
    due to the
    $13.1
    million reversal of cumulative to date revenue as a result of entering into the
    2017
    Ginkgo Partnership Agreement. See Note
    10.
    Revenue Recognition.
     
    See Note
    10,
    "Revenue Recognition" for details of the Company's revenue agreements with DSM.
     
    Related Party Accounts Receivable
     
    Related party accounts receivable was as follows:
     
    December 31,

    (In thousands)
      2018   2017
    DSM   $
    1,071
        $
    12,823
     
    Novvi    
    188
         
    1,607
     
    Total    
    90
         
    238
     
    Related party accounts receivable, net   $
    1,349
        $
    14,668
     
     
    In addition to the amounts shown above, there were the following amounts on the consolidated balance sheet at
    December 
    31,
    2018:
     
       
    a total of
    $8.0
    million of unbilled receivables from DSM, in the lines captioned “Accounts receivable, unbilled - related party” and “Accounts receivable, unbilled, noncurrent - related party”; and
     
       
    $4.3
    million of contingent consideration receivable from DSM in the line captioned "Other assets".
     
    Related Party Accounts Payable
     
    Amounts due to DSM that were included in Accounts payable and Accrued and other current liabilities at
    December 31, 2018
    were
    $2.1
    million and
    $0.6
    million, respectively.
     
    Related Party DSM Transactions
     
    The Company is party to the following significant agreements (and related amendments) with related party DSM:
     
    Related to
    Agreement
    For Additional Information, See the Note Indicated
    Debt DSM Credit Agreement
    5.
    Debt
    10.
    Revenue Recognition
    Debt DSM Note
    5.
    Debt
    Debt
    November 2018
    DSM Letter Agreement
    5.
    Debt
    Divestiture
    November 2017
    Quota Purchase Agreement
    13.
    Divestiture
    Divestiture
    December 2017
    DSM Transition Services Agreement
    13.
    Divestiture
    Equity
    May 2017
    Offerings
    7.
    Stockholders' Deficit
    Equity
    August 2017
    DSM Offering
    7.
    Stockholders' Deficit
    Equity
    November 2018
    DSM Securities Purchase Agreement
    7.
    Stockholders' Deficit
    Revenue
    July
    and
    September 2017
    Collaboration and Licensing Agreements
    10.
    Revenue Recognition
    Revenue
    December 2017
    DSM Supply Agreement
    10.
    Revenue Recognition
    Revenue
    December 2017
    DSM Value Sharing Agreement, as amended
    10.
    Revenue Recognition
    Revenue
    December 2017
    DSM Performance Agreement
    10.
    Revenue Recognition
    Revenue
    November 2017
    Intellectual Property License Agreement
    10.
    Revenue Recognition
    Revenue
    November 2018
    Supply Agreement Amendment
    10.
    Revenue Recognition
     
    Concurrent with the sale of Amyris Brasil in
    December 2017,
    the Company and DSM entered into a series of commercial agreements including (i) a license agreement to DSM of its farnesene product for DSM to use in the Vitamin E and lubricant markets; (ii) a royalty agreement that DSM will pay the Company specified royalties representing a portion of the profit on the sale of Vitamin E produced from farnesene under the Nenter Supply Agreement assigned to DSM; (iii) a performance agreement, which provides an option for DSM to elect a technology transfer upon the achievement of certain development milestones associated with the optimization of farnesene strains; and (iv) a transition services agreement for the Company to provide finance, legal, logistics, and human resource services to support the Brotas facility under DSM ownership for a
    six
    -month period with a DSM option to extend for
    six
    additional months. At closing, DSM paid the Company a nonrefundable license fee of
    $27.5
    million and a nonrefundable royalty payment of
    $15.0
    million. In addition, in
    December 2017
    the Company entered into a credit agreement with DSM under which the Company borrowed
    $25
    million; see Note
    5,
    "Debt" for additional information.
     
    In
    June 2018,
    DSM paid the Company a non-refundable minimum royalty payment of
    $9.3
    million (net of a
    $0.7
    million early payment discount) and will also owe the Company a final payment of
    $8.1
    million in
    2019.
    The future nonrefundable minimum annual royalty payments were determined to be fixed and determinable with a fair value of
    $17.8
    million and were included as part of the total arrangement consideration subject to allocation of this overall multiple-element divestiture transaction.
     
    In
    November 2018,
    the Company amended the supply agreement with DSM to secure capacity at the Brotas
    1
    facility for Reb M production thru
    2022.
    See Note
    10,
    “Revenue Recognition” for information regarding the
    November 2018
    Supply Agreement Amendment and the
    November 2018
    DSM Securities Purchase Agreement. The Company also entered into other transactions with DSM in
    November 2018
    which resulted in the Company (i) evaluating this series of
    November 2018
    transactions and considering other certain transactions with DSM in
    2018
    as a combined arrangement, and (ii) determining and allocating the fair value to each element. The other transactions entered into concurrently with the
    November 2018
    Supply Agreement Amendment and
    November 2018
    DSM Securities Purchase Agreement included an agreement to finalize the working capital adjustments related to the Brotas
    1
    facility sale in
    December 2017
    and an amendment to reduce the exercise price of the Cash Warrant issued to DSM in the
    August 2017
    DSM Offering and to provide a waiver for any potential claims arising from failure to obtain consent prior to amending the exercise price of the
    August 2017
    Vivo Cash Warrant in the
    August 2017
    Warrant transaction.
     
    The contractual consideration transferred to DSM under the combined arrangement was
    $34.7
    million. The Company performed an analysis to determine the fair value of the elements and allocated (i)
    $24.4
    million to the manufacturing capacity, (ii)
    $6.8
    million to the legal settlement and related consent waiver and (iii)
    $2.1
    million to the working capital adjustment. Of the
    $24.4
    million fair value allocated to the manufacturing capacity,
    $3.3
    million was recorded as deferred cost of revenue during the period ended
    December 31, 2018
    and the remaining
    $21.0
    million will be recorded as deferred cost of revenue in the period the additional payments are due and payable to DSM. The deferred cost of revenue asset will be expensed on a units of production basis as products are sold over the
    five
    -year term of the supply agreement and evaluated for recoverability at each period end. The
    $6.8
    million of fair value allocated to the legal settlement and related consent waiver was recorded as legal settlement expense for the year ended
    December 31, 2018.
    The
    $2.1
    million of fair value allocated to the working capital adjustment was recorded as a loss on divestiture for the year ended
    December 31, 2018.
    The contractual consideration transferred to DSM exceeded the fair value of the elements received by
    $1.4
    million and this excess was recorded as a reduction of licenses and royalties revenues in the
    three
    months ended
    December 31, 2018.
     
    Related Party Joint Venture
     
    In
    December 2016,
    the Company, Nikko Chemicals Co., Ltd. an existing commercial partner of the Company, and Nippon Surfactant Industries Co., Ltd., an affiliate of Nikko (collectively, Nikko) entered into a joint venture (the Aprinnova JV Agreement) pursuant to which the Company contributed certain assets, including certain intellectual property and other commercial assets relating to its business-to-business cosmetic ingredients business (the Aprinnova JV Business), as well as its Leland production facility. The Company also agreed to provide the Aprinnova JV with exclusive (to the extent
    not
    already granted to a
    third
    party), royalty-free licenses to certain of the Company's intellectual property necessary to make and sell products associated with the Aprinnova JV Business (the Aprinnova JV Products). Nikko purchased their
    50%
    interest in the Aprinnova JV in exchange for the following payments to the Company: (i) an initial payment of
    $10.0
    million and (ii) the profits, if any, distributed to Nikko in cash as members of the Aprinnova JV during the
    three
    -year period from
    2017
    to
    2019,
    up to a maximum of
    $10.0
    million.
     
    The Aprinnova JV operates in accordance with the Aprinnova Operating Agreement under which the Aprinnova JV is managed by a Board of Directors consisting of
    four
    directors:
    two
    appointed by the Company and
    two
    appointed by Nikko. In addition, Nikko has the right to designate the Chief Executive Officer of the Aprinnova JV from among the directors and the Company has the right to designate the Chief Financial Officer. The Company determined that it has the power to direct the activities of the Aprinnova JV that most significantly impact its economic performance because of its (i) significant control and ongoing involvement in operational decision making, (ii) guarantee of production costs for certain Aprinnova JV products, as discussed below, and (iii) control over key supply agreements, operational and administrative personnel and other production inputs. The Company has concluded that the Aprinnova JV is a variable-interest entity (VIE) under the provisions of ASC
    810,
    Consolidation, and that the Company has a controlling financial interest and is the VIE's primary beneficiary. As a result, the Company accounts for its investment in the Aprinnova JV on a consolidation basis in accordance with ASC
    810.
     
    Under the Aprinnova Operating Agreement, profits from the operations of the Aprinnova JV, if any, are distributed as follows: (i) first, to the Company and Nikko (the Members) in proportion to their respective unreturned capital contribution balances, until each Member’s unreturned capital contribution balance equals
    zero
    and (ii) second, to the Members in proportion to their respective interests. In addition, any future capital contributions will be made by the Company and Nikko on an equal (
    50%/50%
    ) basis each time, unless otherwise mutually agreed.
     
    Pursuant to the Aprinnova JV Agreement, the Company and Nikko agreed to make working capital loans to the Aprinnova JV in the amounts of
    $0.5
    million and
    $1.5
    million, respectively, as described in more detail in Note
    5,
    “Debt” under “Aprinnova Working Capital Loans”. In addition, the Company agreed to guarantee a maximum production cost for squalane and hemisqualane to be produced by the Aprinnova JV and to bear any cost of production above such guaranteed costs.
     
    In connection with the contribution of the Leland Facility by the Company to the Aprinnova JV, at the closing of the formation of the Aprinnova JV, Nikko made a loan to the Company in the principal amount of
    $3.9
    million, and the Company in consideration therefore issued a promissory note to Nikko in an equal principal amount, as described in more detail in Note
    5,
    “Debt” under “Nikko Note.”
     
    The following presents the carrying amounts of the Aprinnova JV’s assets and liabilities included in the accompanying consolidated balance sheets. Assets presented below are restricted for settlement of the Aprinnova JV's obligations and all liabilities presented below can only be settled using the Aprinnova JV resources.
     
    December 31,
    (In thousands)
      2018   2017
    Assets   $
    12,904
        $
    7,635
     
    Liabilities   $
    2,364
        $
    3,187
     
     
    The Aprinnova JV's assets and liabilities are primarily comprised of inventory, property, plant and equipment, accounts payable and debt, which are classified in the same categories in the Company's consolidated balance sheets.
     
    There was
    no
    change in noncontrolling interest for the Aprinnova JV for the years ended
    December 
    31,
    2018
    and
    2017,
    due to profit sharing provisions whereby the Company retains
    100%
    of the profits from
    2017
    to
    2020.
     
    Office Sublease
     
    The Company subleases certain office space to Novvi, for which the Company charged Novvi
    $0.6
    million and
    $0.5
    million for the years ended
    December 
    31,
    2018
    and
    2017,
    respectively.
     
    See Note
    16,
    “Subsequent Events” for information regarding related party transactions subsequent to
    December 
    31,
    2018.
    XML 95 R28.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 2 - Restatement of Consolidated Financial Statements (Tables)
    12 Months Ended
    Dec. 31, 2018
    Notes Tables  
    Schedule of Error Corrections and Prior Period Adjustments [Table Text Block]
        December 31, 2017  
    (In thousands)   As Previously Reported     Corrections     Ref.   As Restated  
    Assets                      
    Current assets:                            
    Cash and cash equivalents   $
    57,059
        $
    —  
       
     
      $
    57,059
     
    Restricted cash    
    2,994
         
    —  
       
     
       
    2,994
     
    Accounts receivable, net    
    24,281
         
    (5,328
    )  
    a
       
    18,953
     
    Accounts receivable - related party, net    
    9,340
         
    (4,573
    )  
    a
       
    4,767
     
    Accounts receivable, unbilled - related party    
         
    9,901
       
     
       
    9,901
     
    Inventories    
    5,408
         
    —  
       
     
       
    5,408
     
    Prepaid expenses and other current assets    
    5,525
         
    (606
    )  
    b
       
    4,919
     
    Total current assets    
    104,607
         
    (606
    )  
     
       
    104,001
     
    Property, plant and equipment, net    
    13,892
         
    —  
       
     
       
    13,892
     
    Accounts receivable, unbilled, noncurrent – related party    
    7,940
         
    —  
       
     
       
    7,940
     
    Restricted cash, noncurrent    
    959
         
    —  
       
     
       
    959
     
    Recoverable taxes from Brazilian government entities    
    1,445
         
    —  
       
     
       
    1,445
     
    Other assets    
    22,640
         
    (10,081
    )  
    c
       
    12,559
     
    Total assets   $
    151,483
        $
    (10,687
    )  
     
      $
    140,796
     
    Liabilities, Mezzanine Equity and Stockholders' Deficit                            
    Current liabilities:                            
    Accounts payable   $
    15,921
        $
    (406
    )  
    d
      $
    15,515
     
    Accrued and other current liabilities    
    29,402
         
    (200
    )  
    e
       
    29,202
     
    Contract liabilities    
    4,880
         
    (572
    )  
    f
       
    4,308
     
    Debt, current portion    
    36,924
         
    —  
       
     
       
    36,924
     
    Related party debt, current portion    
    20,019
         
    —  
       
     
       
    20,019
     
    Total current liabilities    
    107,146
         
    (1,178
    )  
     
       
    105,968
     
    Long-term debt, net of current portion    
    61,893
         
    (1,673
    )  
    g
       
    60,220
     
    Related party debt, net of current portion    
    46,541
         
    —  
       
     
       
    46,541
     
    Derivative liabilities    
    119,978
         
    (3,481
    )  
    h
       
    116,497
     
    Other noncurrent liabilities    
    10,632
         
    13,026
       
    i
       
    23,658
     
    Total liabilities    
    346,190
         
    6,694
       
     
       
    352,884
     
    Commitments and contingencies                            
    Mezzanine equity:                            
    Contingently redeemable common stock    
    5,000
         
    —  
       
     
       
    5,000
     
    Stockholders’ deficit:                            
    Preferred stock    
    —  
         
    —  
       
     
       
    —  
     
    Common stock - $0.0001 par value    
    5
         
    —  
       
     
       
    5
     
    Additional paid-in capital    
    1,048,274
         
    66,272
       
    j
       
    1,114,546
     
    Accumulated other comprehensive loss    
    (42,156
    )    
    —  
       
     
       
    (42,156
    )
    Accumulated deficit    
    (1,206,767
    )    
    (83,653
    )  
    k
       
    (1,290,420
    )
    Total Amyris, Inc. stockholders’ deficit    
    (200,644
    )    
    (17,381
    )  
     
       
    (218,025
    )
    Noncontrolling interest    
    937
         
    —  
       
     
       
    937
     
    Total stockholders' deficit    
    (199,707
    )    
    (17,381
    )  
     
       
    (217,088
    )
    Total liabilities, mezzanine equity and stockholders' deficit   $
    151,483
        $
    (10,687
    )  
     
      $
    140,796
     
      Year Ended
    December 31, 2017
    (In thousands, except shares and per share amounts)   As Previously Reported  
    Reclassifications
    (1)
      Corrections   Ref   As Restated
                         
                         
    Renewable products   $
    45,781
        $
    (3,411
    )   $
       
     
      $
    42,370
     
    Licenses and royalties    
    57,703
         
    6,774
         
    (15,774
    )  
    ab
       
    48,703
     
    Grants and collaborations    
    39,960
         
    (3,363
    )    
    1
           
    36,598
     
    Total revenue    
    143,444
         
         
    (15,773
    )  
     
       
    127,671
     
    Cost and operating expenses    
     
         
         
     
       
     
       
     
     
    Cost of products sold    
    62,713
         
         
    (406
    )  
    ad
       
    62,307
     
    Research and development    
    57,027
         
    (72
    )    
    607
       
    ae
       
    57,562
     
    Sales, general and administrative    
    63,219
         
    72
         
    562
       
    af
       
    63,853
     
    Total cost and operating expenses    
    182,959
         
         
    763
       
     
       
    183,722
     
    Loss from operations    
    (39,515
    )    
         
    (16,536
    )  
     
       
    (56,051
    )
    Other income (expense)                                    
    (Loss) gain on divestiture    
    5,732
         
         
       
     
       
    5,732
     
    Interest expense    
    (34,033
    )    
         
    (3,048
    )  
    ah
       
    (37,081
    )
    (Loss) gain from change in fair value of derivative instruments    
    (1,742
    )    
         
    (47,110
    )  
    ai
       
    (48,852
    )
    Loss upon extinguishment of debt    
    (1,521
    )    
         
    (10,376
    )  
    ak
       
    (11,897
    )
    Other income (expense), net    
    (955
    )    
         
    (1
    )  
     
       
    (956
    )
    Total other expense, net    
    (32,519
    )    
         
    (60,535
    )  
     
       
    (93,054
    )
    Loss before income taxes    
    (72,034
    )    
         
    (77,071
    )  
     
       
    (149,105
    )
    Provision for income taxes    
    (295
    )    
         
    (6,582
    )  
    am
       
    (6,877
    )
    Net loss attributable to Amyris, Inc.    
    (72,329
    )    
         
    (83,653
    )  
     
       
    (155,982
    )
    Less deemed dividend on capital distribution to related parties    
    (8,648
    )    
         
    8,648
       
    an
       
     
    Less deemed dividend related to beneficial conversion feature on Series A preferred stock    
    (562
    )    
         
       
     
       
    (562
    )
    Less deemed dividend related to beneficial conversion feature on Series B preferred stock    
    (634
    )    
         
       
     
       
    (634
    )
    Less deemed dividend related to beneficial conversion feature on Series D preferred stock    
    (5,757
    )    
         
       
     
       
    (5,757
    )
    Less deemed dividend upon settlement of make-whole provision on Series A preferred stock    
         
         
    (10,505
    )  
    ap
       
    (10,505
    )
    Less deemed dividend upon settlement of make-whole provision on Series B preferred stock    
         
         
    (22,632
    )  
    aq
       
    (22,632
    )
    Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series A preferred stock    
         
         
    (21,578
    )  
    ar
       
    (21,578
    )
    Less deemed dividend related to proceeds discount and issuance costs upon conversion of Series B preferred stock    
         
         
    (24,366
    )  
    as
       
    (24,366
    )
    Less cumulative dividends on Series A and Series B preferred stock    
    (5,439
    )    
         
    5,439
       
    aw
       
     
    Add: losses allocated to participating securities    
         
         
    40,159
       
    au
       
    40,159
     
    Net loss attributable to Amyris, Inc. common stockholders   $
    (93,369
    )    
        $
    (108,488
    )  
     
      $
    (201,857
    )
                                         
    Net loss per share attributable to common stockholders                                    
    Basic and diluted   $
    (2.89
    )    
     
         
     
       
     
      $
    (6.26
    )
    Weighted-average shares of common stock outstanding used in computing loss per share of common stock:                                    
    Basic and diluted    
    32,253,570
         
     
         
     
       
     
       
    32,253,570
     
        Year Ended December 31, 2017
    (In thousands)
      As Previously Reported   Corrections
    (1)
      As Restated
                 
    Operating activities                        
    Net loss   $
    (72,329
    )    
    (83,653
    )   $
    (155,982
    )
    Adjustments to reconcile net loss to net cash used in operating activities:                        
    Depreciation and amortization    
    11,358
         
         
    11,358
     
    (Gain) loss on disposal of property, plant and equipment    
    142
         
         
    142
     
    Stock-based compensation    
    6,265
         
         
    6,265
     
    Amortization of debt discount    
    12,490
         
    2,749
         
    15,239
     
    (Gain) loss upon extinguishment of debt    
    1,521
         
    10,376
         
    11,897
     
    Receipt of equity in connection with collaboration arrangements revenue    
    (2,661
    )    
    2,661
         
     
    (Gain) loss from change in fair value of derivative liabilities    
    1,742
         
    47,110
         
    48,852
     
    (Gain) loss on foreign currency exchange rates    
    (1,230
    )    
         
    (1,230
    )
    Noncash revenue reduction related to issuance of debt obligations    
         
    13,413
         
    13,413
     
    Non-cash gain on divestiture    
    (5,732
    )    
         
    (5,732
    )
    Receipt of noncash consideration in connection with license revenue    
    (8,046
    )    
         
    (8,046
    )
    Changes in assets and liabilities:                        
    Accounts receivable    
    (19,647
    )    
         
    (19,647
    )
    Accounts receivable, unbilled – related party
       
    (7,940
    )    
         
    (7,940
    )
    Inventories    
    (3,126
    )    
         
    (3,126
    )
    Prepaid expenses and other assets    
    (19,336
    )    
    606
         
    (18,730
    )
    Accounts payable    
    5,858
         
    (406
    )    
    5,452
     
    Accrued and other liabilities    
    7,295
         
    6,582
         
    13,877
     
    Contract liabilities    
    (7,241
    )    
         
    (7,241
    )
    Net cash used in operating activities    
    (100,617
    )    
    (562
    )    
    (101,179
    )
    Investing activities                        
    Proceeds from divestiture    
    54,827
         
         
    54,827
     
    Change in short-term investments    
    712
         
    581
         
    1,293
     
    Change in restricted cash    
    865
         
    (865
    )    
     
    Purchases of property, plant and equipment    
    (4,412
    )    
         
    (4,412
    )
    Net cash (used in) provided by investing activities    
    51,992
         
    (284
    )    
    51,708
     
    Financing activities                        
    Proceeds from issuance of convertible preferred stock    
    101,124
         
    (2,878
    )    
    98,246
     
    Proceeds from exercises of common stock options    
    160
         
    (160
    )    
     
    Payment of minimum employee taxes withheld upon net share settlement of restricted stock units    
    (385
    )    
         
    (385
    )
    Proceeds from issuance of common stock in August 2017 offering    
         
    5,759
         
    5,759
     
    Issuance costs incurred    
         
    (2,159
    )    
    (2,159
    )
    Change in restricted cash related to contingently redeemable common stock    
    1,046
         
    (1,046
    )    
     
    Proceeds from issuance of debt, net of issuance costs    
    18,925
         
         
    18,925
     
    Principal payments on debt    
    (37,500
    )    
         
    (37,500
    )
    Payment of swap termination    
    (3,113
    )    
         
    (3,113
    )
    Payment on early redemption of debt    
    (1,909
    )    
         
    (1,909
    )
    Net cash provided by financing activities    
    78,348
         
    (484
    )    
    77,864
     
    Effect of exchange rate changes on cash, cash equivalents and restricted cash    
    186
         
         
    186
     
    Net (decrease) increase in cash, cash equivalents and restricted cash    
    29,909
         
    (1,330
    )    
    28,579
     
    Cash, cash equivalents and restricted cash at beginning of year    
    27,150
         
    5,283
         
    32,433
     
    Cash, cash equivalents and restricted cash at end of year   $
    57,059
         
    3,953
         
    61,012
     
                             
    Reconciliation of cash, cash equivalents and restricted cash to the consolidated balance sheets                        
    Cash and cash equivalents    
     
         
     
        $
    57,059
     
    Restricted cash, current    
     
         
     
         
    2,994
     
    Restricted cash, noncurrent    
     
         
     
         
    959
     
    Total cash, cash equivalents and restricted cash    
     
         
     
        $
    61,012
     
                             
    Supplemental disclosures of cash flow information:                        
    Cash paid for interest   $
    11,539
        $
        $
    11,539
     
    Supplemental disclosures of non-cash investing and financing activities:                        
    Issuance of common stock upon conversion of debt   $
    28,702
        $
        $
    28,702
     
    Accrued interest added to debt principal   $
    2,816
        $
        $
    2,816
     
    Issuance of common stock for settlement of debt principal and interest payments   $
    3,436
        $
        $
    3,436
     
    Financing of insurance premium under note payable   $
    467
        $
        $
    467
     
    Issuance of convertible preferred stock upon conversion of debt   $
    40,204
        $
        $
    40,204
     
    Settlement of debt principal by a related party   $
    25,000
        $
        $
    25,000
     
    Issuance of note payable in exchange for debt extinguishment with third party   $
    16,954
        $
        $
    16,954
     
    Issuance of common stock for settlement of debt   $
    10,708
        $
        $
    10,708
     
    Issuance of preferred stock attributed to derivative liabilities   $
        $
    72,725
        $
    72,725
     
    XML 96 R97.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 14 - Income Taxes - Uncertain Tax Benefits (Details) - USD ($)
    $ in Thousands
    12 Months Ended
    Dec. 31, 2018
    Dec. 31, 2017
    Balance $ 28,833 $ 9,101
    Increases in tax positions for prior period 55 50
    Increases in tax positions during current period 1,239 19,682
    Balance $ 30,127 $ 28,833
    XML 97 R67.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 8 - Net Loss Per Share Attributable to Common Stockholders - Calculation of Basic and Diluted Net Loss Per Share of Common Stock (Details) - USD ($)
    $ / shares in Units, $ in Thousands
    1 Months Ended 3 Months Ended 12 Months Ended
    Aug. 31, 2017
    Dec. 31, 2017
    Dec. 31, 2018
    Dec. 31, 2017
    Less deemed dividend related to beneficial conversion feature on Series A preferred stock     $ (562)
    Less deemed dividend related to beneficial conversion feature on Series B preferred stock     (634)
    Less deemed dividend related to beneficial conversion feature on Series D preferred stock     (5,757)
    Add: losses allocated to participating securities     13,991 40,159 [1]
    Net loss attributable to Amyris, Inc. common stockholders     $ (223,096) $ (201,857)
    Weighted-average shares of common stock outstanding used in computing net loss per share of common stock, basic and diluted (in shares)     60,405,910 32,253,570
    Basic and diluted loss per share (in dollars per share)     $ (3.69) $ (6.26)
    Series A Preferred Stock [Member]        
    Less deemed dividend upon settlement of make-whole provision on preferred stock $ (10,500)   $ (10,505)
    Less deemed dividend related to the recognition of discounts on Series A preferred stock upon conversion     (21,578)
    Series B Preferred Stock [Member]        
    Less deemed dividend upon settlement of make-whole provision on preferred stock     (22,632)
    Less deemed dividend related to the recognition of discounts on Series A preferred stock upon conversion     (24,366)
    Series D Preferred Stock [Member]        
    Less deemed dividend related to beneficial conversion feature on Series A preferred stock   $ (5,800)    
    Less deemed dividend related to the recognition of discounts on Series A preferred stock upon conversion     $ (6,852)
    [1] Correction in the computation of loss per share to reflect participating securities.
    XML 98 R63.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 6 - Mezzanine Equity (Details Textual) - USD ($)
    $ / shares in Units, $ in Thousands
    12 Months Ended
    Apr. 08, 2016
    Dec. 31, 2018
    Dec. 31, 2017
    Share Price   $ 3.34 $ 3.75
    Proceeds from Issuance of Private Placement   $ 1,415
    Gates Foundation Purchase Agreement [Member]      
    Stock Issued During Period, Shares, New Issues 292,398    
    Share Price $ 17.10    
    Proceeds from Issuance of Private Placement $ 5,000    
    Compound Annual Return 10.00%    
    Research and Development Obligation, Remaining Amount   $ 700  
    XML 99 R93.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 14 - Income Taxes - Components of Benefit (Provision) (Details) - USD ($)
    $ in Thousands
    12 Months Ended
    Dec. 31, 2018
    Dec. 31, 2017
    Current:    
    Federal $ 6,564
    State 18
    Foreign 964
    Total current provision 7,546
    Deferred:    
    Federal (669)
    State
    Foreign
    Total deferred benefit (669)
    Total provision for income taxes$ $ 6,877 [1]
    [1] Tax provision to accrue liability for unrecognized tax benefit.
    XML 100 R4.htm IDEA: XBRL DOCUMENT v3.19.3
    Consolidated Statements of Operations - USD ($)
    $ in Thousands
    12 Months Ended
    Dec. 31, 2018
    Dec. 31, 2017
    Revenue    
    Revenues $ 63,604 $ 127,671
    Cost and operating expenses    
    Cost of products sold 36,698 62,307 [1]
    Research and development 68,722 57,562 [2]
    Sales, general and administrative 90,902 63,853 [3]
    Impairment of other assets 3,865
    Total cost and operating expenses 200,187 183,722 [3]
    Loss from operations (136,583) (56,051)
    Other income (expense)    
    (Loss) gain on divestiture (1,778) 5,732
    Interest expense (42,703) (37,081) [4]
    Loss from change in fair value of derivative instruments (30,880) (48,852) [5]
    Gain from change in fair value of debt 2,082
    Loss upon extinguishment of debt (17,424) (11,897) [6]
    Other income (expense), net (2,949) (956)
    Total other expense, net (93,652) (93,054)
    Loss before income taxes (230,235) (149,105)
    Provision for income taxes (6,877) [7]
    Net loss attributable to Amyris, Inc. (230,235) (155,982)
    Less deemed dividend related to beneficial conversion feature on Series A preferred stock (562)
    Less deemed dividend related to beneficial conversion feature on Series B preferred stock (634)
    Less deemed dividend related to beneficial conversion feature on Series D preferred stock (5,757)
    Less deemed dividend upon settlement of make-whole provision on Series A preferred stock (10,505) [8]
    Less deemed dividend upon settlement of make-whole provision on Series B preferred stock (22,632) [8]
    Less deemed dividend related to the recognition of discounts on Series A preferred stock upon conversion (21,578) [8]
    Less deemed dividend related to the recognition of discounts on Series B preferred stock upon conversion (24,366) [8]
    Less deemed dividend related to proceeds discount upon conversion of Series D preferred stock (6,852)
    Add: losses allocated to participating securities 13,991 40,159 [9]
    Net loss attributable to Amyris, Inc. common stockholders $ (223,096) $ (201,857)
    Weighted-average shares of common stock outstanding used in computing net loss per share of common stock, basic and diluted (in shares) 60,405,910 32,253,570
    Basic and diluted loss per share (in dollars per share) $ (3.69) $ (6.26)
    Product [Member]    
    Revenue    
    Revenues $ 33,598 $ 42,370
    Licenses and Royalties [Member]    
    Revenue    
    Revenues 7,658 48,703 [10]
    Grants and Collaborations [Member]    
    Revenue    
    Revenues $ 22,348 $ 36,598
    [1] Correction in connection with a sales return, and adjustment to uninvoiced receipts liability.
    [2] Write-off of unrecoverable receivable in connection with facilities subleased to a related party, and reclassification of operating expense by classification to conform to the Company's current presentation.
    [3] Expense incurred in connection with May 2017 equity offering.
    [4] Correction to amortization of debt discounts, and interest expense in connection with partnership payments obligation.
    [5] Correction to accounting for make-whole liability in connection with May 2017 Offering.
    [6] Loss on extinguishment of related and unrelated party debt.
    [7] Tax provision to accrue liability for unrecognized tax benefit.
    [8] Correction to record deemed dividend in connection with discounts and freestanding instruments related to preferred stock offerings.
    [9] Correction in the computation of loss per share to reflect participating securities.
    [10] Ginkgo partnership obligation and promissory note issuance recorded as reduction to revenue and correction of errors in recording revenue from non-cash consideration.
    XML 101 R40.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 1 - Basis of Presentation and Summary of Significant Accounting Policies (Details Textual) - USD ($)
    12 Months Ended
    Jan. 01, 2019
    Dec. 28, 2017
    Dec. 31, 2018
    Dec. 31, 2017
    Sep. 16, 2019
    Jul. 24, 2019
    Dec. 10, 2018
    Dec. 06, 2018
    Jan. 01, 2018
    Working Capital     $ 119,500,000            
    Retained Earnings (Accumulated Deficit), Ending Balance     (1,521,417,000) $ (1,290,420,000) [1]          
    Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net, Total     17,100,000            
    Debt, Changes in Fair Value, Gain (Loss)     2,082,000          
    Long-term Debt, Total     209,697,000 163,704,000          
    Long-term Debt, Current Maturities, Including Due to Related Parties     147,677,000 56,943,000          
    Cash, Cash Equivalents, and Short-term Investments, Total     45,400,000            
    Disposal Group, Not Discontinued Operation, Gain (Loss) on Disposal   $ 5,700,000 (1,778,000) 5,732,000          
    Accumulated Other Comprehensive Income (Loss), Foreign Currency Translation Adjustment, Net of Tax, Ending Balance     43,300,000 42,200,000          
    Foreign Currency Transaction Gain (Loss), before Tax, Total     2,223,000 1,230,000          
    Assets, Total     127,925,000 140,796,000          
    Liabilities, Total     339,744,000 352,884,000          
    Accounting Standards Update 2014-09 [Member]                  
    Retained Earnings (Accumulated Deficit), Ending Balance                 $ (800,000)
    Accounting Standards Update 2016-02 [Member]                  
    Assets, Total $ 25,700,000                
    Operating Lease, Liability, Total 33,600,000                
    Operating Lease, Right-of-Use Asset 29,700,000                
    Liabilities, Total 24,900,000                
    Accounting Standards Update 2017-11 [Member]                  
    Increase (Decrease) in Derivative Liabilities (41,000,000)                
    Stockholders' Equity, Period Increase (Decrease), Total $ 41,000,000                
    Other Expense, Net [Member]                  
    Foreign Currency Transaction Gain (Loss), before Tax, Total     $ 1,600,000 $ 400,000          
    Machinery, Equipment, and Fixtures [Member] | Minimum [Member]                  
    Property, Plant and Equipment, Useful Life     3 years            
    Machinery, Equipment, and Fixtures [Member] | Maximum [Member]                  
    Property, Plant and Equipment, Useful Life     15 years            
    Building [Member]                  
    Property, Plant and Equipment, Useful Life     15 years            
    DSM [Member]                  
    Charge Related to Final Working Capital Adjustments Between the Company and a Counterparty     $ 1,800,000            
    Convertible Senior Notes, 6.0%, Due in 2021, Second Exchange [Member] | Subsequent Event [Member]                  
    Debt Instrument, Debt Default, Amount         $ 63,600,000        
    Debt Instrument, Interest Rate, Stated Percentage           18.00%      
    Convertible Senior Notes, 6.0% Due in 2021 [Member]                  
    Debt, Changes in Fair Value, Gain (Loss)     $ 2,100,000            
    Debt Instrument, Interest Rate, Stated Percentage     6.00%       6.00% 6.00%  
    [1] Sum of adjustments to net loss for the year ended December 31, 2017 as result of corrections.
    XML 102 R44.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 2 - Restatement of Consolidated Financial Statements - Consolidated Financial Statements (Details) (Parentheticals) - $ / shares
    Dec. 31, 2018
    Dec. 31, 2017
    Common stock, par value (in dollars per share) $ 0.0001 $ 0.0001
    XML 103 R8.htm IDEA: XBRL DOCUMENT v3.19.3
    Consolidated Statements of Stockholders' Deficit and Mezzanine Equity (Parentheticals) - USD ($)
    $ in Thousands
    12 Months Ended
    Dec. 31, 2018
    Dec. 31, 2017
    Series B Preferred Stock [Member]    
    Issuance costs   $ 0
    Issuance costs   860
    Series D Preferred Stock [Member]    
    Issuance costs   $ 176
    Additional Paid-in Capital [Member]    
    Issuance costs $ 0  
    Issuance costs $ 0  
    XML 104 R48.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 3 - Balance Sheet Details - Prepaid Expenses and Other Current Assets (Details) - USD ($)
    $ in Thousands
    Dec. 31, 2018
    Dec. 31, 2017
    Prepayments, advances and deposits $ 5,644 $ 3,599
    Recoverable taxes from Brazilian government entities 631 87
    Other 4,291 1,233
    Total prepaid expenses and other current assets $ 10,566 $ 4,919 [1]
    [1] Write-off of unrecoverable receivable in connection with facilities subleased to a related party.
    XML 105 R29.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 3 - Balance Sheet Details (Tables)
    12 Months Ended
    Dec. 31, 2018
    Notes Tables  
    Allowance for Doubtful Accounts Activity and Balances [Table Text Block] <div style="display: inline; font-family: times new roman; font-size: 10pt"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; min-; min-width: 700px;"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; font-weight: bold; text-decoration: underline"><div style="display: inline; text-decoration: underline;">(In thousands)</div></td> <td style="font-weight: bold"> </td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Balance at <br /> Beginning of Year</td> <td style="font-weight: bold; border-bottom: Black 1pt solid"> </td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Provisions</td> <td style="font-weight: bold; border-bottom: Black 1pt solid"> </td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Recoveries <br /> (Write-offs), Net</td> <td style="font-weight: bold; border-bottom: Black 1pt solid"> </td> <td colspan="3" style="white-space: nowrap; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Balance at <br /> End of Year</td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Allowance for doubtful accounts:</td> <td> </td> <td style="text-align: left"> </td> <td style="text-align: right"> </td> <td style="white-space: nowrap; text-align: left"> </td> <td> </td> <td style="text-align: left"> </td> <td style="text-align: right"> </td> <td style="white-space: nowrap; text-align: left"> </td> <td> </td> <td style="text-align: left"> </td> <td style="text-align: right"> </td> <td style="white-space: nowrap; text-align: left"> </td> <td> </td> <td style="text-align: left"> </td> <td style="text-align: right"> </td> <td style="white-space: nowrap; text-align: left"> </td> </tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 48%">Year Ended December 31, 2018</td> <td style="width: 1%"> </td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">642</div></td> <td style="white-space: nowrap; width: 1%; text-align: left"> </td> <td style="width: 1%"> </td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">–</div></td> <td style="white-space: nowrap; width: 1%; text-align: left"> </td> <td style="width: 1%"> </td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right">–</td> <td style="white-space: nowrap; width: 1%; text-align: left"> </td> <td style="width: 1%"> </td> <td style="width: 1%; text-align: left">$</td> <td style="width: 10%; text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">642</div></td> <td style="white-space: nowrap; width: 1%; text-align: left"> </td> </tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td>Year Ended December 31, 2017 (as restated, Note 2)</td> <td> </td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">501</div></td> <td style="white-space: nowrap; text-align: left"> </td> <td> </td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">141</div></td> <td style="white-space: nowrap; text-align: left"> </td> <td> </td> <td style="text-align: left">$</td> <td style="text-align: right">–</td> <td style="white-space: nowrap; text-align: left"> </td> <td> </td> <td style="text-align: left">$</td> <td style="text-align: right"><div style="display: inline; font-style: italic; font-weight: inherit; font-style: normal;">642</div></td> <td style="white-space: nowrap; text-align: left"> </td> </tr> </table></div>
    Schedule of Inventory, Current [Table Text Block]
    December 31,
    (In thousands)
      2018   2017
               
    (As Restated, Note 2)
    Raw materials   $
    3,901
        $
    819
     
    Work in process    
    539
         
    364
     
    Finished goods    
    5,253
         
    4,225
     
    Total inventories   $
    9,693
        $
    5,408
     
    Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Table Text Block]
    December 31,
    (In thousands)
      2018   2017
               
    (As Restated, Note 2)
    Prepayments, advances and deposits   $
    5,644
        $
    3,599
     
    Recoverable taxes from Brazilian government entities    
    631
         
    87
     
    Other    
    4,291
         
    1,233
     
    Total prepaid expenses and other current assets   $
    10,566
        $
    4,919
     
    Property, Plant and Equipment [Table Text Block]
    December 31,
    (In thousands)
      2018   2017
            (As Restated, Note 2)
    Machinery and equipment   $
    43,713
        $
    46,317
     
    Leasehold improvements    
    39,922
         
    40,036
     
    Computers and software    
    9,987
         
    9,555
     
    Furniture and office equipment, vehicles and land    
    3,016
         
    3,415
     
    Construction in progress    
    1,749
         
    2,838
     
    Total property, plant and equipment, gross    
    98,387
         
    102,161
     
    Less: accumulated depreciation and amortization    
    (78,631
    )    
    (88,269
    )
    Total property, plant and equipment, net   $
    19,756
        $
    13,892
     
    Schedule of Other Assets, Noncurrent [Table Text Block]
    December 31,
    (In thousands)
      2018   2017
            (As Restated, Note 2)
    Contingent consideration   $
    4,286
        $
    8,150
     
    Deposits    
    2,465
         
    2,462
     
    Other    
    1,207
         
    1,947
     
    Total other assets   $
    7,958
        $
    12,559
     
    Schedule of Accrued and Other Current Liabilities [Table Text Block]
    December 31,
    (In thousands)
      2018   2017
               
    (As Restated, Note 2)
    Payroll and related expenses   $
    9,220
        $
    7,238
     
    Contract termination fees    
    4,092
         
     
    Accrued interest    
    3,853
         
    8,213
     
    Asset retirement obligation
    (1)
       
    3,063
         
    3,587
     
    Ginkgo partnership payments obligation    
    2,155
         
     
    Tax-related liabilities    
    2,139
         
    5,837
     
    Professional services    
    1,173
         
    1,694
     
    Other    
    3,284
         
    2,633
     
    Total accrued and other current liabilities   $
    28,979
        $
    29,202
     
    Other Noncurrent Liabilities [Table Text Block]
    December 31,
    (In thousands)
      2018   2017
            (As Restated, Note 2)
    Liability for unrecognized tax benefit   $
    6,582
        $
    6,582
     
    Deferred rent, net of current portion    
    6,440
         
    7,818
     
    Ginkgo partnership payments obligation, net of current portion    
    6,185
         
    6,444
     
    Contract liabilities, net of current portion    
    1,587
         
    383
     
    Contract termination fees, net of current portion
    (1)
       
    1,530
         
     
    Capital leases, net of current portion    
    195
         
    217
     
    Other    
    673
         
    2,214
     
    Total other noncurrent liabilities   $
    23,192
        $
    23,658
     
    XML 106 R25.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 16 - Subsequent Events
    12 Months Ended
    Dec. 31, 2018
    Notes to Financial Statements  
    Subsequent Events [Text Block]
    16.
    Subsequent Events
     
    Extension and Exchange of Tranche II Note
     
    On
    January 14, 2019,
    Wolverine Flagship Fund Trading Limited (Wolverine) agreed to waive payment of the Tranche II Note held by Wolverine (see Note
    5,
    “Debt”) at maturity until
    July 15, 2019
    in exchange for a fee, payable on or prior to
    July 15, 2019,
    of
    $0.6
    million. Effective
    July 15, 2019,
    the due date of the waiver fee was extended to
    October 13, 2019
    and will bear interest at a rate of
    1.75%
    per month, compounded, from
    July 16, 2019
    to the date of payment.
     
    Evergreen Shares for
    2010
    Equity Incentive Plan and
    2010
    Employee Stock Purchase Plan
     
    In
    February 2019,
    the Company's Board of Directors (the Board) approved increases to the number of shares available for issuance under the Company's
    2010
    Equity Incentive Plan (the Equity Plan) and
    2010
    Employee Stock Purchase Plan (the Purchase Plan). These shares in connection with the Equity Plan represented an automatic annual increase in the number of shares available for grant and issuance under the Equity Plan of
    3,828,241
    shares. This increase is equal to approximately
    5.0%
    of the
    76,564,829
    total outstanding shares of the Company’s common stock as of
    December 
    31,
    2018.
    This automatic increase was effective as of
    January 1, 2019.
    These shares in connection with the Purchase Plan represented an automatic annual increase in the number of shares reserved for issuance under the Purchase Plan of
    382,824
    shares. This increase is equal to approximately
    0.5%
    of the
    76,564,829
    total outstanding shares of the Company’s common stock as of
    December 
    31,
    2018.
    This automatic increase was effective as of
    January 1, 2019.
     
    Cannabinoid Agreement
     
    On
    March 18, 2019,
    the Company entered into a
    $300
    million research, collaboration and license agreement (the Cannabinoid Agreement) with LAVVAN, Inc., a newly formed investment-backed company (Lavvan), for the development, manufacture and commercialization of cannabinoids. Under the agreement, the Company would perform research and development activities and Lavvan would be responsible for the commercialization of the cannabinoids developed under the agreement. The Cannabinoid Agreement is being principally funded on a milestone basis, with the Company also entitled to receive certain supplementary research and development funding from Lavvan. The Company could receive aggregate funding of up to
    $300
    million over the term of the Cannabinoid Agreement if all of the milestones are achieved. Additionally, the agreement provides for profit share to the Company on Lavvan's gross profit margin once products are commercialized; these payments will be due for the next
    20
    years. The consummation of the transactions contemplated by the Cannabinoid Agreement is subject to certain conditions, including obtaining certain
    third
    party consents and releases and the repayment or refinancing of the
    2014
    Rule
    144A
    Convertible Notes and the
    2015
    Rule
    144A
    Convertible Notes (see Note
    5,
    “Debt”). On
    May 2, 2019,
    the parties consummated the transactions contemplated by the Cannabinoid Agreement, including the formation of a special purpose entity to hold certain intellectual property created during the collaboration (the Cannabinoid Collaboration IP), the licensing of certain Company intellectual property to Lavvan, the licensing of the Cannabinoid Collaboration IP to the Company and Lavvan, and the granting by the Company to Lavvan of a lien on the Company background intellectual property being licensed to Lavvan under the Cannabinoid Agreement, which lien would be subordinated to the lien on such intellectual property under the GACP Term Loan Facility (see Note
    5,
    “Debt”).
     
    LSA Amendments, Assignment and Waivers
     
    On
    April 4, 2019,
    the Company and GACP amended the LSA (see Note
    5,
    “Debt”) to (i) effective
    December 31, 2018,
    eliminate the conditions giving rise to the early maturity date, so that loans under the GACP Term Loan Facilities would have a maturity date of
    July 1, 2021, (
    ii) remove certain Company intellectual property related to the Cannabinoid Agreement from the lien granted by the Company to GACP under the LSA, (iii) eliminate the Company’s ability to obtain the Incremental GACP Term Loan Facility, (iv) eliminate the Company’s reinvestment rights with respect to mandatory prepayments upon asset sales, (v) restrict the Company’s ability to pay interest and principal on other indebtedness without the consent of GACP, and (vi) provide that the Company must have at all times at least
    $15
    million of unrestricted, unencumbered cash subject to a control agreement in favor of GACP.
     
    On
    April 4, 2019,
    the Company and GACP entered into a waiver agreement, pursuant to which GACP agreed to waive breaches of certain covenants under the LSA occurring prior to, as of and after
    December 31, 2018
    through
    April 8, 2019,
    including covenants related to quarterly minimum revenues, minimum liquidity amounts and a minimum asset coverage ratio. In connection with such waiver, the Company agreed to pay GACP fees of
    $0.8
    million.
     
    On
    April 15, 2019,
    the Company, GACP and Foris Ventures, LLC (Foris, an entity affiliated with director John Doerr of Kleiner Perkins Caufield & Byers, a current stockholder, and an owner of greater than
    five
    percent of the Company’s outstanding common stock) entered into a Loan Purchase Agreement, pursuant to which Foris agreed to purchase and assume from GACP, and GACP agreed to sell and assign to Foris, the outstanding loans under the LSA and all documents and assets related thereto. In connection with such purchase and assignment, the Company agreed to repay Foris
    $2.5
    million of the purchase price paid by Foris to GACP (the Company LPA Obligation). The closing of the loan purchase and assignment occurred on
    April 16, 2019.
     
    On
    August 14, 2019,
    the Company and Foris entered into an Amendment
    No
    5
    and Waiver to the LSA (the LSA Amendment and Waiver), pursuant to which (i) the maturity date of the loans under the LSA was extended from
    July 1, 2021
    to
    July 1, 2022, (
    ii) the interest rate for the loans under the LSA was modified from the sum of (A) the greater of (
    x
    ) the prime rate as reported in the Wall Street Journal or (y) 
    4.75%
    plus (B) 
    9%
    to the greater of (A)
    12%
    or (B) the rate of interest payable with respect to any indebtedness of the Company, (iii) the amortization of the loans under the LSA was delayed until
    December 16, 2019, (
    iv) certain accrued and future interest and agency fee payments under the LSA were delayed until
    December 16, 2019, (
    v) certain covenants under the LSA, including related definitions, were amended to provide the Company with greater operational and financial flexibility, including, without limitation, to permit the incurrence of the indebtedness under the Naxyris Loan Facility (as described below) and the granting of liens with respect thereto, subject to the terms of an intercreditor agreement between Foris and Naxyris S.A. (Naxyris) governing the respective rights of the parties with respect to, among other things, the assets securing the Naxyris Loan Agreement and the LSA (the Intercreditor Agreement), (vi) certain outstanding unsecured promissory notes issued by the Company to Foris on
    April 8, 2019,
    June 11, 2019,
    July 10, 2019
    and
    July 26, 2019 (
    as described below under “Foris Credit Agreements”), in an aggregate principal amount of
    $32.5
    million, as well as the Company LPA Obligation, were added to the loans under the LSA, made subject to the LSA and secured by the security interest in the collateral granted to Foris under the LSA, and such promissory notes and contractual obligation were cancelled in connection therewith, and (vii) Foris agreed to waive certain existing defaults under the LSA. After giving effect to the LSA Amendment and Waiver, there is
    $71.0
    million aggregate principal amount of loans outstanding under the LSA, including with respect to covenants related to quarterly minimum revenues, minimum liquidity amounts and a minimum asset coverage ratio. In connection with the entry into the LSA Amendment and Waiver, on
    August 14, 2019
    the Company issued to Foris a warrant to purchase up to
    1,438,829
    shares of Common Stock at an exercise price of
    $2.87
    per share, with an exercise term of
    two
    years from issuance. Pursuant to the terms of the warrant, Foris
    may
    not
    exercise the Foris Warrant to the extent that, after giving effect to such exercise, Foris, together with its affiliates, would beneficially own in excess of
    19.99%
    of the number of shares of common stock outstanding after giving effect to such exercise, unless the Company has obtained stockholder approval to exceed such limit in accordance with Nasdaq rules and regulations, which the Company intends to seek at its
    2019
    annual meeting of stockholders.
     
    Foris Credit Agreements
     
    On
    April 8, 2019,
    the Company and Foris entered into an agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of
    $8.0
    million, which the Company borrowed in full on
    April 8, 2019
    and issued to Foris a promissory note in the principal amount of
    $8.0
    million (the
    April
    Foris Note). The
    April
    Foris Note has a maturity date of
    October 14, 2019.
    In connection with the entry into the
    April
    Foris Credit Agreement and the issuance of the
    April
    Foris Note, which has
    no
    stated interest rate, the Company agreed to pay Foris a fee of
    $1.0
    million, payable on or prior to the maturity date of the
    April
    Foris Note (the
    April
    Foris Note Fee); provided, that the
    April
    Foris Note Fee would be reduced to
    $0.5
    million if the Company repaid the
    April
    Foris Note in full by
    July 15, 2019.
    The
    April
    Foris Note is subordinated in right of payment to the Tranche II Note held by Wolverine (see Note
    5,
    “Debt” and above in this Note
    16,
    “Subsequent Events”).
     
    On
    June 11, 2019,
    the Company and Foris entered into an agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of
    $8.5
    million, which the Company borrowed in full on
    June 11, 2019
    and issued to Foris a promissory note in the principal amount of
    $8.5
    million (the
    June
    Foris Note). The
    June
    Foris Note (i) accrues interest at a rate of
    12.5%
    per annum from and including
    June 11, 2019,
    which interest is payable on the maturity date or the earlier repayment or other satisfaction of the
    June
    Foris Note, and (ii) matures on
    August 28, 2019;
    provided, that if the
    May 2017
    Cash Warrant held by DSM and the
    August 2017
    DSM Cash Warrant (see Note
    7,
    “Stockholders’ Deficit”) are exercised, then the maturity date of the
    June
    Foris Note will be the business day immediately following such exercise.
     
    On
    July 10, 2019,
    the Company and Foris entered into a credit agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of
    $16.0
    million (the
    July
    Foris Credit Agreement), of which the Company borrowed
    $8.0
    million on
    July 10, 2019
    and
    $8.0
    million on
    July 26, 2019
    and issued to Foris promissory notes, each in the principal amount of
    $8.0
    million, on such dates (the
    July
    Foris Notes). The
    July
    Foris Notes (i) accrue interest at a rate of
    12.5%
    per annum from and including the respective date of issuance, which interest is payable on the maturity date or the earlier repayment or other satisfaction of the applicable
    July
    Foris Note, and (ii) mature on
    December 31, 2019.
    In connection with the entry into the
    July
    Foris Credit Agreement, the Company and Foris amended the warrant issued to Foris on
    August 17, 2018 (
    see Note
    7,
    “Stockholders’ Deficit”) to reduce the exercise price of such warrant from
    $7.52
    per share to
    $2.87
    per share.
     
    The Company
    may
    at its option repay the amounts outstanding under the
    April
    Foris Note (including the
    April
    Foris Note Fee), the
    June
    Foris Note and the
    July
    Foris Notes before their respective maturity dates, in whole or in part, at a price equal to
    100%
    of the amount being repaid plus, in the case of the
    June
    Foris Note and the
    July
    Foris Notes, accrued and unpaid interest on such amount to the date of repayment.
     
    On
    August 14, 2019,
    the
    April
    Foris Note, the
    June
    Foris Note and the
    July
    Foris Notes were added to the loans under the LSA, made subject to the LSA and secured by the security interest in the collateral granted to Foris under the LSA, and such notes were cancelled in connection therewith. See above under “LSA Amendments, Assignment and Waivers” for additional information.
     
    On
    August 28, 2019,
    the Company and Foris entered into a credit agreement to make available to the Company an unsecured credit facility in an aggregate principal amount of
    $19.0
    million (the
    August
    Foris Credit Agreement), which the Company borrowed in full on
    August 28, 2019
    and issued to Foris a promissory note in the principal amount of
    $19.0
    million (the
    August
    Foris Note). The
    August
    Foris Note (i) accrues interest at a rate of
    12%
    per annum from and including
    August 28, 2019,
    which interest is payable quarterly in arrears on each
    March 31,
    June 30,
    September 30
    and
    December 31,
    beginning
    December 31, 2019,
    and (ii) matures on
    January 1, 2023.
    The Company
    may
    at its option repay the amounts outstanding under the
    August
    Foris Note before the maturity date, in whole or in part, at a price equal to
    100%
    of the amount being repaid plus accrued and unpaid interest on such amount to the date of repayment.
     
    In connection with the entry into the
    August
    Foris Credit Agreement, on
    August 28, 2019
    the Company issued to Foris a warrant to purchase up to
    4,871,795
    shares of Common Stock at an exercise price of
    $3.90
    per share, with an exercise term of
    two
    years from issuance in a private placement pursuant to the exemption from registration under Section
    4
    (a)(
    2
    ) of the Securities Act of
    1933,
    as amended (the Securities Act), and Regulation D promulgated under the Securities Act. The exercise price of the warrant is subject to standard adjustments but does
    not
    contain any anti-dilution protection, and the warrants only permit “cashless” or “net” exercise after the
    six
    -month anniversary of issuance of the applicable warrant, and only to the extent that there is
    not
    an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, Foris
    may
    not
    exercise the warrant to the extent that, after giving effect to such exercise, Foris, together with its affiliates, would beneficially own in excess of
    19.99%
    of the number of shares of common stock outstanding after giving effect to such exercise, unless the Company has obtained stockholder approval to exceed such limit in accordance with Nasdaq rules and regulations, which the Company intends to seek at its
    2019
    annual meeting of stockholders.
     
    Private Placements
     
    On
    April 
    16,
    2019,
    the Company sold and issued to Foris
    6,732,369
    shares of common stock at a price of
    $2.87
    per share, as well as a warrant to purchase up to
    5,424,804
    shares of common stock at an exercise price of
    $2.87
    per share, with an exercise term of
    two
    years from issuance, in a private placement pursuant to the exemption from registration under Section
    4
    (a)(
    2
    ) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of
    $20.0
    million (the Foris Investment). The Company used the proceeds from the Foris Investment to repay a portion of the
    2015
    Rule
    144A
    Convertible Notes (see Note
    5,
    “Debt”).
     
    On
    April 26, 2019,
    the Company sold and issued (i)
    2,832,440
    shares of common stock at a price of
    $5.12
    per share, as well as a warrant to purchase up to
    3,983,230
    shares of common stock at an exercise price of
    $5.12
    per share, with an exercise term of
    two
    years from issuance, to Foris and (ii) an aggregate of
    2,043,781
    shares of common stock at a price of
    $4.02
    per share, as well as warrants to purchase up to an aggregate of
    1,635,025
    shares of common stock at an exercise price of
    $5.02
    per share, with an exercise term of
    two
    years from issuance, to certain other non-affiliated investors, in each case in private placements pursuant to the exemption from registration under Section
    4
    (a)(
    2
    ) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of
    $23.2
    million. On
    August 28, 2019,
    in connection with the entry into the
    August
    Foris Credit Agreement (as described above under "Foris Credit Agreements"), the Company and Foris amended the warrant issued to Foris on
    April 26, 2019
    to reduce the exercise price of such warrant from
    $5.12
    per share to
    $3.90
    per share.
     
    On
    April 29, 2019,
    the Company sold and issued (i)
    913,529
    shares of common stock at a price of
    $4.76
    per share, as well as a warrant to purchase up to
    1,212,787
    shares of common stock at an exercise price of
    $4.76
    per share, with an exercise term of
    two
    years from issuance, to Vivo and (ii) an aggregate of
    323,382
    shares of common stock at a price of
    $4.02
    per share, as well as warrants to purchase up to an aggregate of
    258,704
    shares of common stock at an exercise price of
    $5.02
    per share, with an exercise term of
    two
    years from issuance, to certain other non-affiliated investors, in each case in private placements pursuant to the exemption from registration under Section
    4
    (a)(
    2
    ) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of
    $5.8
    million.
     
    On
    May 3, 2019,
    the Company sold and issued
    1,243,781
    shares of common stock at a price of
    $4.02
    per share, as well as a warrant to purchase up to
    995,024
    shares of common stock at an exercise price of
    $5.02
    per share, with an exercise term of
    two
    years from issuance, to a non-affiliated investor in a private placement pursuant to the exemption from registration under Section
    4
    (a)(
    2
    ) of the Securities Act and Regulation D promulgated under the Securities Act, for aggregate cash proceeds to the Company of
    $5
    million.
     
    The exercise price of the warrants issued in the foregoing private placements is subject to standard adjustments but does
    not
    contain any anti-dilution protection, and the warrants only permit “cashless” or “net” exercise after the
    six
    -month anniversary of issuance of the applicable warrant, and only to the extent that there is
    not
    an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, in connection with the foregoing private placements, the Company agreed
    not
    to effect any exercise or conversion of any Company security, and the investors agreed
    not
    to exercise or convert any portion of any Company security, to the extent that after giving effect to such exercise or conversion, the applicable investor, together with its affiliates, would beneficially own in excess of
    19.99%
    of the number of shares of common stock outstanding immediately after giving effect to such exercise or conversion, and the warrants contained a similar limitation. The Company intends to seek stockholder approval for Foris to exceed such limitation in accordance with Nasdaq rules and regulations at its
    2019
    annual meeting of stockholders.
     
    DSM Agreements
     
    On
    April 16, 2019,
    the Company assigned to DSM, and DSM assumed, all of the Company’s rights and obligations under the Value Sharing Agreement (see Note
    10,
    “Revenue Recognition”), for aggregate consideration to the Company of
    $57.0
    million,
    $29.1
    million of which was paid to the Company in cash, with the remaining
    $27.9
    million being used to pay certain existing obligations of the Company to DSM, including certain obligations under the Supply Agreement Amendment (see Note
    10,
    “Revenue Recognition”). The Company used a majority of the cash proceeds to repay a portion of the
    2015
    Rule
    144A
    Convertible Notes (see Note
    5,
    “Debt”).
     
    In addition, on
    April 16, 2019
    the Company and DSM entered into amendments to the Supply Agreement and the Performance Agreement (see Note
    10,
    “Revenue Recognition”), as well as the Quota Purchase Agreement relating to the
    December 2017
    sale of Amyris Brasil to DSM (see Note
    13,
    “Divestiture” and Note
    11,
    "Related Party Transactions"), pursuant to which (i) DSM agreed to reduce certain manufacturing costs and fees paid by the Company related to the production of farnesene under the Supply Agreement through
    2021,
    as well as remove the priority of certain customers over the Company with respect to production capacity at the Brotas, Brazil facility, (ii) the Company agreed to provide DSM rights to conduct certain process and downstream recovery improvements under the Performance Agreement at facilities other than the Brotas, Brazil facility in exchange for DSM providing the Company with a license to such improvements and (iii) the Company released DSM from its obligation to provide manufacturing and support services under the Quota Purchase Agreement in connection with the Company’s planned new manufacturing facility, which is
    no
    longer planned to be located at the Brotas, Brazil location.
     
    On
    September 17, 2019,
    the Company and DSM entered into a credit agreement (the
    “2019
    DSM Credit Agreement”) to make available to the Company a secured credit facility in an aggregate principal amount of
    $8.0
    million, to be issued in separate installments of
    $3.0
    million,
    $3.0
    million and
    $2.0
    million, respectively, with each installment being subject to certain closing conditions, including the payment of certain existing obligations of the Company to DSM. On
    September 17, 2019,
    the Company borrowed the
    first
    installment of
    $3.0
    million under the
    2019
    DSM Credit Agreement, all of which proceeds were used to pay certain existing obligations of the Company to DSM, and issued to DSM a promissory note in the principal amount of
    $3.0
    million. On
    September 19, 2019,
    the Company borrowed the
    second
    installment of
    $3.0
    million under the
    2019
    DSM Credit Agreement, all of which proceeds were used to pay certain existing obligations of the Company to DSM, and issued to DSM a promissory note in the principal amount of
    $3.0
    million. On
    September 23, 2019,
    the Company borrowed the final installment of
    $2.0
    million under the
    2019
    DSM Credit Agreement,
    $1.5
    million of which proceeds were used to pay certain existing obligations of the Company to DSM, and issued to DSM a promissory note in the principal amount of
    $2.0
    million. The promissory notes issued under the
    2019
    DSM Credit Agreement (i) mature on
    August 7, 2022, (
    ii) accrue interest at a rate of
    12.5%
    per annum from and including the applicable date of issuance, which interest is payable quarterly in arrears on each
    January 1,
    April 1,
    July 1
    and
    October 1,
    beginning
    January 1, 2020,
    and (iii) are secured by a
    first
    -priority lien on certain Company intellectual property licensed to DSM. The Company
    may
    at its option repay the amounts outstanding under the
    2019
    DSM Credit Agreement before the maturity date, in whole or in part, at a price equal to
    100%
    of the amount being repaid plus accrued and unpaid interest on such amount to the date of repayment. In addition, the Company is required to repay the amounts outstanding under the
    2019
    DSM Credit Agreement (i) in an amount equal to the gross cash proceeds, if any, received by the Company upon the exercise by DSM of any of the common stock purchase warrants issued by the Company to DSM on
    May 11, 2017
    or
    August 7, 2017 (
    see Note
    7,
    “Stockholders’ Deficit”) and (ii) in full upon the request of DSM at any time following the receipt by the Company of at least
    $50.0
    million of gross cash proceeds from
    one
    or more sales of equity securities of the Company on or prior to
    June 30, 2020.
     
    Raizen Joint Venture Agreement
     
    On
    May 10, 2019,
    the Company and Raizen Energia S.A. (Raizen) entered into an agreement relating to the formation and operation of a joint venture relating to the production, sale and commercialization of alternative sweetener products. In connection with the formation of the joint venture, among other things, (i) the joint venture will construct a manufacturing facility on land owned by Raizen and leased to the joint venture (the Sweetener Plant), (ii) the Company will grant to the joint venture an exclusive, royalty-free, worldwide, license to certain technology owned by the Company relevant to the joint venture’s business, and (iii) the Company and Raizen will enter into a shareholders agreement setting forth the rights and obligations of the parties with respect to, and the management of, the joint venture. The formation of the joint venture is subject to certain conditions, including certain regulatory approvals and the achievement of certain technological and economic milestones relating to the Company’s existing production of its alternative sweetener product. If such conditions are
    not
    satisfied by
    December 31, 2019,
    the joint venture will automatically terminate. In addition, notwithstanding the satisfaction of the closing conditions, Raizen
    may
    elect
    not
    to consummate the formation and operation of the joint venture, in which event, the Company will retain the right to construct and operate the Sweetener Plant.
     
    Upon the closing of the joint venture, each party will make an initial capital contribution to the joint venture of
    2,500,000
    Brazilian Real (
    R$2,500,000
    ) and the joint venture will be owned
    50%
    by the Company and
    50%
    by Raizen. Within
    60
    days of the formation, the parties will make an aggregate cash contribution to the joint venture of
    U.S.$9,000,000
    to purchase certain fixed assets currently owned by the Company and located at the site of the Company’s former joint venture with Sao Martinho S.A. in Pradopolis, Brazil for
    U.S.$3,000,000.
    In addition, within
    six
    months of the formation, the Company will contribute to the joint venture its existing supply agreements related to its alternative sweetener product, subject to certain exceptions, in exchange for shares of dividend-bearing preferred stock in the joint venture, which will be entitled, for a period of
    10
    years commencing from the initial date of operation of the Sweetener Plant, to certain priority fixed cumulative dividends including, in the event that certain technological and economic milestones are met in any fiscal quarter, a percentage of the operating cash flow of the joint venture in such quarter.
     
    After the formation of the joint venture, the parties will
    not
    conduct activities similar or identical to the joint venture. In the event that certain technological and economic milestones are
    not
    met in any fiscal year beginning with the
    third
    fiscal year after formation of the joint venture and ending with the
    seventh
    fiscal year after formation of the joint venture, Raizen shall have the right to sell all of its shares in the joint venture to the Company at a price per share equal to the higher of the book value and the amount of Raizen’s investments in the joint venture, as adjusted for Raizen’s cost of capital.
     
    2014
    Rule
    144A
    Convertible Notes Exchanges
     
    On
    May 10, 2019,
    the Company exchanged
    $13.5
    million aggregate principal amount of the
    2014
    Rule
    144A
    Convertible Notes (see Note
    5,
    “Debt”) held by certain non-affiliated investors, including accrued and unpaid interest thereon up to, but excluding,
    May 15, 2019,
    for an aggregate of
    3,479,008
    shares of common stock and warrants to purchase an aggregate of
    1,391,603
    shares of common stock at an exercise price of
    $5.02
    per share, with an exercise term of
    two
    years from issuance, in a private exchange pursuant to the exemption from registration under Section
    3
    (a)(
    9
    ) of the Securities Act.
     
    On
    May 14, 2019,
    the Company exchanged
    $5.0
    million aggregate principal amount of the
    2014
    Rule
    144A
    Convertible Notes held by Foris, including accrued and unpaid interest thereon up to, but excluding,
    May 15, 2019,
    for
    1,122,460
    shares of common stock and a warrant to purchase up to
    352,638
    shares of common stock at an exercise price of
    $4.56
    per share, with an exercise term of
    two
    years from issuance, in a private exchange pursuant to the exemption from registration under Section
    3
    (a)(
    9
    ) of the Securities Act. On
    August 28, 2019,
    in connection with the entry into the
    August
    Foris Credit Agreement (as described above under "Foris Credit Agreements"), the Company and Foris amended the warrant issued to Foris on
    May 14, 2019
    to reduce the exercise price of such warrant from
    $4.56
    per share to
    $3.90
    per share.
     
    On
    May 15, 2019,
    the Company exchanged
    $10.0
    million aggregate principal amount of the
    2014
    Rule
    144A
    Convertible Notes held by Maxwell (Mauritius) Pte Ltd for
    2,500,000
    shares of common stock in a private exchange pursuant to the exemption from registration under Section
    3
    (a)(
    9
    ) of the Securities Act.
     
    On
    May 15, 2019,
    the Company exchanged
    $9.7
    million aggregate principal amount of the
    2014
    Rule
    144A
    Convertible Notes held by Total for a new senior convertible note with an equal principal amount and with substantially identical terms, except that the new note had a maturity date of
    June 14, 2019,
    in a private exchange pursuant to the exemption from registration under Section
    3
    (a)(
    9
    ) of the Securities Act. Effective
    June 14, 2019,
    the Company and Total agreed to extend the maturity date of the new note from
    June 14, 2019
    to
    July 18, 2019.
    Effective
    July 18, 2019,
    the Company and Total agreed to (i) further extend the maturity date of the new note from
    July 18, 2019
    to
    August 28, 2019
    and (ii) increase the interest rate on the new note to
    10.5%
    per annum, beginning
    July 18, 2019.
    Effective
    August 28, 2019,
    the Company and Total agreed to (i) further extend the maturity date of the new note from
    August 28, 2019
    to
    October 28, 2019
    and (ii) increase the interest rate on the new note to
    12%
    per annum, beginning
    August 28, 2019.
     
    The exercise price of the warrants issued in the foregoing exchanges is subject to standard adjustments but does
    not
    contain any anti-dilution protection, and the warrants only permit “cashless” or “net” exercise after the
    six
    -month anniversary of the exercisability of the applicable warrant, and only to the extent that there is
    not
    an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, (i) the exercisability of the warrant issued to Foris is subject to stockholder approval in accordance with Nasdaq rules and regulations, which the Company intends to seek at its
    2019
    annual meeting of stockholders, and (ii) each other warrant provides that the Company
    may
    not
    effect any exercise of such warrant to the extent that, after giving effect to such exercise, the applicable holder, together with its affiliates, would beneficially own in excess of
    4.99%
    of the number of shares of common stock outstanding after giving effect to such exercise.
     
    6%
    Convertible Notes due
    2021
    Exchanges
     
    On
    May 15, 2019
    and
    June 24, 2019,
    the Company exchanged
    $53.3
    million and
    $4.7
    million principal amount, respectively, of the
    6%
    Convertible Notes due
    2021
    (see Note
    5,
    “Debt”), including accrued and unpaid interest thereon, representing all then-outstanding
    6%
    Convertible Notes due
    2021,
    for new senior convertible notes with an equal principal amount and warrants to purchase up to
    2,000,000
    and
    181,818
    shares of common stock, respectively, at an exercise price of
    $5.12
    per share, with an exercise term of
    two
    years from issuance, in private exchanges pursuant to the exemption from registration under Section
    3
    (a)(
    9
    ) of the Securities Act. The new notes have substantially identical terms as the
    6%
    Convertible Notes due
    2021
    being exchanged, except that (i) the holders agreed to waive, until
    July 22, 2019,
    certain covenants relating to the effectiveness of the registration statement covering the shares of common stock issuable upon conversion of, or otherwise pursuant to, the new notes and the filing by the Company of reports with the SEC and (ii) during the period from
    July 22, 2019
    to
    July 29, 2019,
    inclusive, the holders have the right to require the Company to redeem the new notes, in whole or in part, at a price equal to
    125%
    of the principal amount being redeemed. The exercise price of the warrants is subject to standard adjustments but does
    not
    contain any anti-dilution protection, and the warrants only permit “cashless” or “net” exercise after the
    six
    -month anniversary of issuance, and only to the extent that there is
    not
    an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition, the holders
    may
    not
    exercise the warrants, and the Company
    may
    not
    effect any exercise of the warrants, to the extent that, after giving effect to such exercise, the applicable holder, together with its affiliates, would beneficially own in excess of
    4.99%
    of the number of shares of common stock outstanding after giving effect to such exercise.
     
    On
    July 26, 2019,
    one
    of the holders of the senior convertibles notes issued in exchange for the
    6%
    Convertible Notes due
    2021,
    holding a senior convertible note in the principal amount of
    $4.7
    million, exercised its right to require the Company to redeem such note in whole at a price equal to
    125%
    of the principal amount being redeemed, plus accrued and unpaid interest on such note to the date of repayment. Redemption of such note was initially due on
    July 30, 2019
    and subsequently extended to
    August 30, 2019.
    The Company redeemed such note in full on
    August 30, 2019.
     
    On
    July 24, 2019,
    Company further exchanged
    $53.3
    million principal amount of the previously-exchanged
    6%
    Convertible Senior Notes due
    2021
    as well as the warrant to purchase up to
    2,000,000
    shares of common stock issued on
    May 15, 2019,
    for a new senior convertible note with a principal amount of
    $68.3
    million (the Second Exchange Note) and a new warrant to purchase up to
    2,000,000
    shares of common stock at an exercise price of
    $2.87
    per share, with an exercise term of
    two
    years from
    May 15, 2019 (
    the Second Exchange Warrant) in a private exchange pursuant to the exemption from registration under Section
    3
    (a)(
    9
    ) of the Securities Act. The Second Exchange Note and Second Exchange Warrant have substantially similar terms as the note and warrant, respectively, issued on
    May 15, 2019,
    except that (i) the principal amount of the Second Exchange Note would be
    $68.3
    million, reflecting accrued and unpaid interest and late charges under the exchanged note and a
    25%
    premium accruing as a result of the Company’s failure to make an installment payment on the exchanged note due
    July 1, 2019
    in the amount of
    $6.4
    million, provided that upon an event of default under the Second Exchange Note, the Company would
    not
    be required to redeem the Second Exchange Note in cash at a price greater than the intrinsic value of the shares of common stock underlying the Second Exchange Note, (ii) the Second Exchange Note bears interest at a rate of
    18%
    per annum, (iii) the holder agreed to extend its waiver of certain covenant breaches relating to the failure by the Company to timely file periodic reports with the SEC from
    July 22, 2019
    to
    September 16, 2019, (
    iv) the
    first
    installment date under the Second Exchange Note will occur on
    October 1, 2019, (
    v) the Company is required to (A) make principal payments on the Second Exchange Note in the amount of
    $3.2
    million on each of
    August 2, 2019
    and
    August 22, 2019,
    and (B) pay all remaining amounts then outstanding under the Second Exchange Note on
    September 16, 2019,
    and if the Company fails to make any such payment on the applicable payment date, the conversion price of the Second Exchange Note will be reset to the volume-weighted average price of the common stock on the trading day immediately following the Company’s filing of a Current Report on Form
    8
    -K with respect to its failure to make the payment due on
    September 16, 2019,
    if such volume-weighted average price is lower than the conversion price of the Second Exchange Note then in effect, subject to a price floor and (vi) the Second Exchange Warrant has an exercise price of
    $2.87
    per share.
     
    On
    September 16, 2019,
    the Company failed to pay an aggregate of
    $63.6
    million of outstanding principal and accrued interest on the Second Exchange Note when due. The failure resulted in an event of default under the Second Exchange Note and also triggered cross-defaults under other debt instruments of the Company which permitted the holders of such indebtedness to accelerate the amounts owing under such instruments. The Company subsequently received waivers from substantially all holders of such other debt instruments to waive the right to accelerate. As a result, the indebtedness with respect to which the Company has obtained such waivers continues to be classified as long-term on the Company’s balance sheet.  The indebtedness reflected by the Second Exchange Note continues to be classified as a current liability on the Company’s balance sheet. In addition, as a result of the payment default, the conversion price of the Second Exchange Note is subject to adjustment in accordance with the terms of the Second Exchange Note.
     
    The Company does
    not
    currently have sufficient funds to repay the amounts outstanding under the Second Exchange Note. To date, negotiations with the holder of the Second Exchange Note have
    not
    been successful, and there can be
    no
    assurance that a favorable outcome for the Company will be reached. The Company has executed a term sheet with an existing investor for a term loan, the proceeds of which would be used to repay a portion of the Second Exchange Note. However, there can be
    no
    assurance that the Company will be able to obtain such financing on its expected timeline, or on acceptable terms, if at all. Even if the Company does obtain such financing, it will
    not
    have sufficient funds to repay the Second Exchange Note in full without obtaining additional financing, which the Company is attempting to source.
     
    The consolidated financial statements do
    not
    include any adjustments that might result from the outcome of this uncertainty.
     
    Exchange of
    August 2013
    Financing Convertible Note
     
    On
    July 8, 2019,
    the
    August 2013
    Financing Convertible Note held by Wolverine (see Note
    4,
    “Debt”) was exchanged for
    1,767,632
    shares of common stock and a warrant to purchase
    1,080,000
    shares of common stock in a private exchange pursuant to the exemption from registration under Section
    3
    (a)(
    9
    ) of the Securities Act. The exercise price of the warrant is subject to standard adjustments but does
    not
    contain any anti-dilution protection, and the warrant only permits “cashless” or “net” exercise after the
    six
    -month anniversary of issuance, and only to the extent that there is
    not
    an effective registration statement covering the resale of the shares of common stock underlying the warrant. In addition, Wolverine
    may
    not
    exercise the warrant to the extent that, after giving effect to such exercise, Wolverine, together with its affiliates, would beneficially own in excess of
    4.99%
    of the number of shares of common stock outstanding after giving effect to such exercise.
     
    Nikko Loan Agreement
     
    On
    July 29, 2019,
    the Company and Nikko Chemicals Co., Ltd. (Nikko) entered into a loan agreement (the Nikko Loan Agreement) to make available to the Company secured loans in an aggregate principal amount of
    $5.0
    million, to be issued in separate installments of
    $3.0
    million and
    $2.0
    million, respectively, with each installment being subject to certain closing conditions, including the entry into certain commercial agreements and other arrangements relating to the Aprinnova JV (see Note
    11,
    “Related Party Transactions”). On
    July 30, 2019,
    the Company borrowed the
    first
    installment of
    $3.0
    million under the Nikko Loan Agreement and received net cash proceeds of
    $2.8
    million, with the remaining
    $0.2
    million being withheld by Nikko as prepayment of the interest payable on such loan through the maturity date. On
    August 8, 2019,
    the Company borrowed the remaining
    $2.0
    million available under the Nikko Loan Agreement and received net cash proceeds of
    $1.9
    million, with the remaining
    $0.1
    million being withheld by Nikko as prepayment of the interest payable on such loan through the maturity date. The loans (i) mature on
    December 18, 2020, (
    ii) accrue interest at a rate of
    5%
    per annum from and including the applicable loan date through the maturity date, which interest is required to be prepaid in full on the date of the applicable loan, and (iii) are secured by a
    first
    -priority lien on
    12.8%
    of the Aprinnova JV interests owned by the Company.
     
    Aprinnova Working Capital Loan
     
    Effective
    July 31, 2019,
    the Company and Nikko agreed to extend the term of the Second Aprinnova Note (see Note
    5,
    “Debt”) from
    August 1, 2019
    to
    August 1, 2020.
     
    Naxyris Loan and Security Agreement
     
    On 
    August 14, 2019,
    the Company, certain of the Company’s subsidiaries (the Subsidiary Guarantors) and, as lender, Naxyris, an existing stockholder of the Company and an investment vehicle owned by Naxos Capital Partners SCA Sicar, which is affiliated with NAXOS S.A.R.L. (Switzerland), for which director Carole Piwnica serves as director, entered into a Loan and Security Agreement (the Naxyris Loan Agreement) to make available to the Company a secured term loan facility in an aggregate principal amount of up to 
    $10,435,000
     (the Naxyris Loan Facility), which the Company borrowed in full on
    August 14, 2019.
     
    Loans under the Naxyris Loan Facility have a maturity date of
    July 1, 2022
    and accrue interest at a rate per annum equal to the greater of (i)
    12%
    or (ii) the rate of interest payable with respect to any indebtedness of the Company plus
    25
    basis points, which interest will be payable monthly in arrears, provided that all interest accruing from and after
    August 14, 2019
    through
    December 1, 2019
    shall be due and payable on
    December 15, 2019.
     
    The obligations of the Company under the Naxyris Loan Facility are (i) guaranteed by the Subsidiary Guarantors and (ii) secured by a perfected security interest in substantially all of the assets of the Company and the Subsidiary Guarantors (the Collateral), junior in payment priority to Foris Ventures subject to certain limitations and exceptions, as well as the terms of the Intercreditor Agreement (as defined above).
     
    Mandatory prepayments of the outstanding amounts under the Naxyris Loan Facility will be required upon the occurrence of certain events, including asset sales, a change in control, and the incurrence of additional indebtedness, subject to certain exceptions and reinvestment rights. Outstanding amounts under the Naxyris Loan Facility must also be prepaid to the extent that the borrowing base exceeds the outstanding principal amount of the loans under the Naxyris Loan Facility. In addition, the Company
    may
    at its option prepay the outstanding principal amount of the loans under the Naxyris Loan Facility in full before the maturity date. Any prepayment of the loans under the Naxyris Loan Facility prior to the maturity date, whether pursuant to a mandatory or optional prepayment, is subject to a prepayment charge equal to
    one
    year’s interest at the then-current interest rate for the Naxyris Loan Facility. Upon the repayment of the loans under the Naxyris loan facility, whether on the maturity date or earlier pursuant to an optional or mandatory prepayment, the Company will pay Naxyris an end of term fee. In addition, (i) the Company will be required to pay a fee equal to
    6%
    of any amount the Company fails to pay within
    three
    business days of its due date and (ii) any interest that is
    not
    paid when due will be added to principal and will bear compound interest at the applicable rate.
     
    The affirmative and negative covenants in the Naxyris Loan Agreement relate to, among other items: (i) payment of taxes; (ii) financial reporting; (iii) maintenance of insurance; and (iv) limitations on indebtedness, liens, mergers, consolidations and acquisitions, transfers of assets, dividends and other distributions in respect of capital stock, investments, loans and advances, and corporate changes. The Naxyris Loan Agreement also contains financial covenants, including covenants related to minimum revenue, liquidity, and asset coverage.
     
    September 2019
    Credit Agreements
     
    On
    September 10, 2019,
    the Company entered into separate credit agreements (the “Investor Credit Agreements”) with each of Schottenfeld Opportunities Fund II, L.P., Phase Five Partners, LP and Koyote Trading, LLC (the “Investors”) to make available to the Company unsecured credit facilities in an aggregate principal amount of
    $12.5
    million, which the Company borrowed in full on
    September 10, 2019
    and issued to the Investors separate promissory notes in the aggregate principal amount of
    $12.5
    million (the “Investor Notes”). Each Investor Note (i) accrues interest at a rate of
    12%
    per annum from and including
    September 10, 2019,
    which interest is payable quarterly in arrears on each
    March 31,
    June 30,
    September 30
    and
    December 31,
    beginning
    December 31, 2019,
    and (ii) matures on
    January 1, 2023.
    The Company
    may
    at its option repay the amounts outstanding under the Investor Notes before the maturity date, in whole or in part, at a price equal to
    100%
    of the amount being repaid plus accrued and unpaid interest on such amount to the date of repayment.
     
    In connection with the entry into the Investor Credit Agreements, on
    September 10, 2019,
    the Company issued to the Investors warrants to purchase up to an aggregate of
    3,205,128
    shares of Common Stock at an exercise price of
    $3.90
    per share, with an exercise term of
    two
    years from issuance in a private placement pursuant to the exemption from registration under Section
    4
    (a)(
    2
    ) of the Securities Act and Regulation D promulgated under the Securities Act. The exercise price of the warrants is subject to standard adjustments but does
    not
    contain any anti-dilution protection, and the warrants only permit “cashless” or “net” exercise after the
    six
    -month anniversary of issuance of the applicable warrant, and only to the extent that there is
    not
    an effective registration statement covering the resale of the shares of common stock underlying the applicable warrant. In addition,
    no
    Investor
    may
    exercise its warrant to the extent that, after giving effect to such exercise, such Investor, together with its affiliates, would beneficially own in excess of
    9.99%
    of the number of shares of common stock outstanding after giving effect to such exercise. In addition, the Company agreed to file a registration statement providing for the resale by the Investors of the shares of Common Stock underlying the warrants with the SEC within
    60
    days following the date of the issuance of the warrants and to use commercially reasonable efforts to (i) cause such registration statement to become effective within
    120
    days following the date of the issuance of the warrants and (ii) keep such registration statement effective until the Investors
    no
    longer beneficially own any such shares of Common Stock or such shares of Common Stock are eligible for resale under Rule
    144
    under the Securities Act without regard to volume limitations. If the Company fails to file the registration statement by the filing deadline or the registration statement is
    not
    declared effective by the effectiveness deadline, or the Company fails to maintain the effectiveness of the registration statement as required by the warrants, then the exercise price of the warrants will be reduced by
    10%,
    and by an additional
    5%
    if such failure continues for longer than
    90
    days, subject to an exercise price floor of
    $3.31
    per share, provided that upon the cure by the Company of such failure, the exercise price of the warrants will revert to
    $3.90
    per share.
     
    In connection with the entry into the Investor Credit Agreements and the issuance of the warrants, on
    September 10, 2019,
    the Company and the Investors entered into a Standstill Agreement (the “Investor Standstill Agreement”), pursuant to which the Investors agreed that, until the earliest to occur of (i) the Investors
    no
    longer beneficially owning any shares underlying the warrants, (ii) the Company entering into a definitive agreement involving the direct or indirect acquisition of all or a majority of the Company’s equity securities or all or substantially all of the Company’s assets or (iii) a person or group, with the prior approval of the Company’s Board of Directors (the “Board”), commencing a tender offer for all or a majority of the Company's equity securities, neither the Investors nor any of their respective affiliates will (without the prior written consent of the Board), among other things, (i) acquire any loans, debt securities, equity securities, or assets of the Company or any of its subsidiaries, or rights or options with respect thereto, except that the Investors shall be permitted to (a) purchase the shares underlying the warrants pursuant to the exercise of the warrants and (b) acquire beneficial ownership of up to
    6.99%
    of the Common Stock, or (ii) make any proposal, public announcement, solicitation or offer with respect to, or otherwise solicit, seek or offer to effect, or instigate, encourage, or assist any
    third
    party with respect to: (a) any business combination, merger, tender offer, exchange offer, or similar transaction involving the Company or any of its subsidiaries; (b) any restructuring, recapitalization, liquidation, or similar transaction involving the Company or any of its subsidiaries; (c) any acquisition of any of the Company’s loans, debt securities, equity securities or assets, or rights or options with respect thereto; or (d) any proposal to seek representation on the Board or otherwise seek to control or influence the management, Board, or policies of the Company, in each case subject to certain exceptions.
    XML 107 R21.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 12 - Stock-based Compensation
    12 Months Ended
    Dec. 31, 2018
    Notes to Financial Statements  
    Share-based Payment Arrangement [Text Block]
    12.
    Stock-based Compensation
     
    Stock-based Compensation Expense Related to All Plans
     
    Stock-based compensation expense related to all employee stock compensation plans, including options, restricted stock units and ESPP, was as follows:
     
    Years Ended December 31,

    (In thousands)
      2018   2017
    Research and development   $
    1,797
        $
    2,204
     
    Sales, general and administrative    
    7,393
         
    4,061
     
    Total stock-based compensation expense   $
    9,190
        $
    6,265
     
     
    Plans
     
    2010
    Equity Incentive Plan
     
    The Company's
    2010
    Equity Incentive Plan (
    2010
    Equity Plan) became effective on
    September 
    27,
    2010
    and will terminate in
    2020.
    The
    2010
    Equity Plan provides for the granting of common stock options, restricted stock awards, stock bonuses, stock appreciation rights, restricted stock units (RSUs) and performance awards. It allows for time-based or performance-based vesting for the awards. Options granted under the
    2010
    Equity Plan
    may
    be either incentive stock options (ISOs) or non-statutory stock options (NSOs). ISOs
    may
    be granted only to Company employees (including officers and directors who are also employees). NSOs
    may
    be granted to Company employees, non-employee directors and consultants. The Company will be able to issue
    no
    more than
    2,000,000
    shares pursuant to the grant of ISOs under the
    2010
    Equity Plan. Options under the
    2010
    Equity Plan
    may
    be granted for periods of up to
    ten
    years. All options issued to date have had a
    ten
    -year life. Under the plan, the exercise price of any ISOs and NSOs
    may
    not
    be less than
    100%
    of the fair market value of the shares on the date of grant. The exercise price of any ISOs and NSOs granted to a
    10%
    stockholder
    may
    not
    be less than
    110%
    of the fair value of the underlying stock on the date of grant. The options and RSUs granted to-date generally vest over
    three
    to
    five
    years.
     
    As of
    December 
    31,
    2018
    and
    2017,
    options were outstanding to purchase
    5,339,214
    and
    1,255,045
    shares, respectively, of the Company's common stock granted under the
    2010
    Equity Plan, with weighted-average exercise prices per share of
    $33.40
    and
    $26.29,
    respectively. In addition, as of
    December 
    31,
    2018
    and
    2017,
    restricted stock units representing the right to receive
    5,294,803
    and
    683,554
    shares, respectively, of the Company's common stock granted under the
    2010
    Equity Plan were outstanding. As of
    December 
    31,
    2018
    and
    2017,
    2,359,750
    and
    252,107
    shares, respectively, of the Company’s common stock remained available for future awards that
    may
    be granted under the
    2010
    Equity Plan.
     
    The number of shares reserved for issuance under the
    2010
    Equity Plan increases automatically on
    January 1
    of each year starting with
    January 
    1,
    2011,
    by a number of shares equal to
    5%
    of the Company’s total outstanding shares as of the immediately preceding
    December 
    31.
    However, the Company’s Board of Directors or the Leadership Development and Compensation Committee of the Board of Directors retains the discretion to reduce the amount of the increase in any particular year.
     
    In
    May 2018,
    shareholders approved amendments to the
    2010
    Equity Plan to (i) increase the number of shares of common stock available for grant and issuance thereunder by
    9.0
    million shares and (ii) increase the annual per-participant award limit thereunder to
    4.0
    million shares. Subsequent to the amendments, the total number of shares available for grant was
    9,280,000,
    not
    including the annual evergreen increases.
     
    2005
    Stock Option/Stock Issuance Plan
     
    In
    2005,
    the Company established its
    2005
    Stock Option/Stock Issuance Plan (
    2005
    Plan) which provided for the granting of common stock options, restricted stock units, restricted stock and stock purchase rights awards to employees and consultants of the Company. The
    2005
    Plan allowed for time-based or performance-based vesting for the awards. Options granted under the
    2005
    Plan were ISOs or NSOs. ISOs were granted only to Company employees (including officers and directors who are also employees). NSOs were granted to Company employees, non-employee directors, and consultants.
     
    All options issued under the
    2005
    Plan had a
    ten
    -year life. The exercise prices of ISOs and NSOs granted under the
    2005
    Plan were
    not
    less than
    100%
    of the estimated fair value of the shares on the date of grant, as determined by the Board of Directors. The exercise price of an ISO and NSO granted to a
    10%
    stockholder could
    not
    be less than
    110%
    of the estimated fair value of the underlying stock on the date of grant as determined by the Board. The options generally vested over
    5
    years.
     
    As of
    December 
    31,
    2018
    and
    2017,
    options to purchase
    52,389
    and
    79,322
    shares, respectively, of the Company’s common stock granted under the
    2005
    Plan remained outstanding, and as a result of the adoption of the
    2010
    Equity Plan discussed above,
    zero
    shares of the Company’s common stock remained available for future awards issuance under the
    2005
    Plan. The options outstanding under the
    2005
    Plan as of
    December 
    31,
    2018
    and
    2017
    had a weighted-average exercise price per share of
    $185.93
    and
    $144.58,
    respectively.
     
    2010
    Employee Stock Purchase Plan
     
    The
    2010
    Employee Stock Purchase Plan (
    2010
    ESPP) became effective on
    September 
    27,
    2010.
    The
    2010
    ESPP is designed to enable eligible employees to purchase shares of the Company’s common stock at a discount. Offering periods under the
    2010
    ESPP generally commence on each
    May 16
    and
    November 16,
    with each offering period lasting for
    one
    year and consisting of
    two six
    -month purchase periods. The purchase price for shares of common stock under the
    2010
    ESPP is the lesser of
    85%
    of the fair market value of the Company’s common stock on the
    first
    day of the applicable offering period or the last day of each purchase period. During the life of the
    2010
    ESPP, the number of shares reserved for issuance increases automatically on
    January 1
    of each year, starting with
    January 
    1,
    2011,
    by a number of shares equal to
    1%
    of the Company’s total outstanding shares as of the immediately preceding
    December 
    31.
    However, the Company’s Board of Directors or the Leadership Development and Compensation Committee of the Board of Directors retains the discretion to reduce the amount of the increase in any particular year. In
    May 2018,
    shareholders approved an amendment to the
    2010
    ESPP to increase the maximum number of shares of common stock that
    may
    be issued over the term of the ESPP by
    1
    million shares.
    No
    more than
    1,666,666
    shares of the Company’s common stock
    may
    be issued under the
    2010
    ESPP and
    no
    other shares
    may
    be added to this plan without the approval of the Company’s stockholders.
     
    2018
    CEO Performance-based Stock Options
     
    In
    May 2018,
    the Company granted its chief executive officer performance-based stock options (PSOs) to purchase
    3,250,000
    shares. PSOs are equity awards with the final number of PSOs that
    may
    vest determined based on the Company’s performance against pre-established EBITDA milestones and Amyris stock price milestones. The EBITDA milestones are measured from the grant date through
    December 31, 2021,
    and the stock price milestones are measured from the grant date through
    December 31, 2022.
    The PSOs vest in
    four
    tranches contingent upon the achievement of both the EBITDA milestones and stock price milestones for each respective tranche, and the chief executive officer’s continued employment with the Company. Over the measurement periods, the number of PSOs that
    may
    be issued and the related stock-based compensation expense that is recognized is adjusted upward or downward based upon the probability of achieving the EBITDA milestones. Depending on the probability of achieving the EBITDA milestones and stock price milestones and certification of achievement of those milestones for each vesting tranche by the Company’s Board of Directors or Compensation Committee, the PSOs issued could be from
    zero
    to
    3,250,000
    stock options, with an exercise price of
    $5.08
    per share.
     
    Stock-based compensation expense for this award is recognized using a graded-vesting approach over the service period beginning at the grant date through
    December 31, 2022,
    as the Company’s management has determined that certain EBITDA milestones are probable of achievement over the next
    four
    years as of
    December 
    31,
    2018,
    The Company utilized a Monte Carlo simulation to estimate the grant date fair value of each tranche of the award which totaled
    $5.1
    million. For the year ended
    December 
    31,
    2018,
    the Company recognized
    $0.7
    million of compensation expense for this award. The assumptions used to estimate the fair value of this award with performance and market vesting conditions were as follows:
     
    Stock Option Award with Performance and Market Vesting Conditions:    
    Fair value of the Company’s common stock on grant date   $
    5.08
     
    Expected volatility    
    70
    %
    Risk-free interest rate    
    2.75
    %
    Dividend yield    
    0.0
    %
     
    Stock Option Activity
     
    Stock option activity is summarized as follows:
     
    Year ended December 31,
      2018   2017
    Options granted    
    4,337,119
         
    661,094
     
    Weighted-average grant-date fair value per share   $
    5.18
        $
    3.26
     
    Compensation expense related to stock options (in millions)   $
    2.6
        $
    3.3
     
    Unrecognized compensation costs as of December 31 (in millions)   $
    8.5
        $
    2.7
     
     
    The Company expects to recognize the
    December 
    31,
    2018
    balance of unrecognized costs over a weighted-average period of
    3.8
    years. Future option grants will increase the amount of compensation expense to be recorded in these periods.
     
    Stock-based compensation expense for stock options and employee stock purchase plan rights is estimated at the grant date and offering date, respectively, based on the fair-value using the Black-Scholes option pricing model. The fair value of employee stock options is amortized on a ratable basis over the requisite service period of the awards. The fair value of employee stock options and employee stock purchase plan rights was estimated using the following weighted-average assumptions:
     
    Years Ended December 31,   2018   2017
    Expected dividend yield    
    —%
         
    —%
     
    Risk-free interest rate    
    2.8
    %    
    2.1
    %
    Expected term (in years)    
    6.90
         
    6.12
     
    Expected volatility    
    80
    %    
    84
    %
     
    The expected life of options is based primarily on historical share option exercise experience of the employees for options granted by the Company. All options are treated as a single group in the determination of expected life, as the Company does
    not
    currently expect substantially different exercise or post-vesting termination behavior among the employee population. The risk-free interest rate is based on the U.S. Treasury yield for a term consistent with the expected life of the awards in effect at the time of grant. Expected volatility is based on the historical volatility of the Company's common stock. The Company has
    no
    history or expectation of paying dividends on common stock.
     
    Stock-based compensation expense associated with options is based on awards ultimately expected to vest. At the time of an option grant, the Company estimates the expected future rate of forfeitures based on historical experience. These estimates are revised, if necessary, in subsequent periods if actual forfeiture rates differ from those estimates. If the actual forfeiture rate is lower than estimated the Company will record additional expense and if the actual forfeiture is higher than estimated the Company will record a recovery of prior expense.
     
    The Company’s stock option activity and related information for the year ended
    December 
    31,
    2018
    was as follows:
     
        Number of
    Stock
    Options
      Weighted-
    average
    Exercise
    Price
     
    Weighted-average
    Remaining
    Contractual
    Life

    (in years)
     
    Aggregate
    Intrinsic
    Value

    (in thousands)
    Outstanding - December 31, 2017    
    1,338,367
        $
    33.40
         
    7.7
        $
    97
     
    Options granted    
    4,337,119
        $
    5.18
         
     
         
     
     
    Options exercised    
    (70,807
    )   $
    3.68
         
     
         
     
     
    Options forfeited or expired    
    (214,409
    )   $
    19.61
         
     
         
     
     
    Outstanding - December 31, 2018    
    5,390,270
        $
    11.55
         
    8.5
        $
    29
     
    Vested or expected to vest after December 31, 2018    
    4,833,615
        $
    12.28
         
    8.4
        $
    28
     
    Exercisable at December 31, 2018    
    972,229
        $
    39.73
         
    5.8
        $
    12
     
     
    The aggregate intrinsic value of options exercised under all option plans was
    $0.2
    million and
    $0
    for the years ended
    December 
    31,
    2018
    and
    2017,
    respectively, determined as of the date of option exercise.
     
    Restricted Stock Units Activity and Expense
     
    During the years ended
    December 
    31,
    2018
    and
    2017,
    5,452,664
    and
    523,167
    RSUs, respectively, were granted with weighted-average service-inception date fair value per unit of
    $5.36
    and
    $5.51,
    respectively. The Company recognized RSU-related stock-based compensation expense of
    $6.4
    million and
    $2.8
    million, respectively, for the years ended
    December 
    31,
    2018
    and
    2017.
    As of
    December 
    31,
    2018
    and
    2017,
    unrecognized RSU-related compensation costs totaled
    $23.8
    million and
    $5.0
    million, respectively.
     
    Stock-based compensation expense for RSUs is measured based on the closing fair market value of the Company's common stock on the date of grant.
     
    The Company’s RSU and restricted stock activity and related information for the year ended
    December 
    31,
    2018
    was as follows:
     
        Number of
    Restricted
    Stock Units
      Weighted-
    average
    Grant-date
    Fair Value
      Weighted-
    average
    Remaining
    Contractual
    Life
    (in years)
    Outstanding - December 31, 2017    
    683,554
        $
    8.66
         
    1.4
     
    Awarded    
    5,452,664
        $
    5.36
         
     
     
    Vested    
    (445,828
    )   $
    8.43
         
     
     
    Forfeited    
    (395,587
    )   $
    5.64
         
     
     
    Outstanding - December 31, 2018    
    5,294,803
        $
    5.50
         
    1.7
     
     Vested or expected to vest after December 31, 2018    
    4,953,264
        $
    5.50
         
    1.6
     
     
    ESPP Activity and Expense
     
    During the years ended
    December 
    31,
    2018
    and
    2017,
    246,230
    and
    47,058
    shares, respectively, of the Company's common stock were purchased under the
    2010
    ESPP. At
    December 
    31,
    2018
    and
    2017,
    382,824
    and
    80,594
    shares, respectively, of the Company’s common stock remained reserved for issuance under the
    2010
    ESPP.
     
    During the years ended
    December 
    31,
    2018
    and
    2017,
    the Company also recognized ESPP-related stock-based compensation expense of
    $0.2
    million and
    $0.1
    million, respectively.
    XML 108 R30.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 4 - Fair Value Measurement (Tables)
    12 Months Ended
    Dec. 31, 2018
    Notes Tables  
    Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
    December 31,
    (In thousands)
      2018   2017 (As Restated, Note 2)
        Level 1   Level 2   Level 3   Total   Level 1   Level 2   Level 3   Total
    Assets                                
    Money market funds   $
         
        $
        $
        $
    53,199
        $
        $
        $
    53,199
     
    Certificates of deposit    
         
         
         
         
         
    4,153
         
         
    4,153
     
    Total assets measured and recorded at fair value   $
         
        $
        $
        $
    53,199
        $
    4,153
        $
        $
    57,352
     
    Liabilities                                                                
    6% Convertible Notes Due 2021   $
         
        $
    57,918
        $
    57,918
        $
        $
        $
        $
     
    Embedded derivatives in connection with the issuance of debt and equity instruments    
         
         
         
         
         
         
    723
         
    723
     
    Freestanding derivative instruments in connection with the issuance of equity instruments    
         
         
    42,796
         
    42,796
         
         
         
    115,774
         
    115,774
     
    Total liabilities measured and recorded at fair value   $
        $
        $
    100,714
        $
    100,714
        $
        $
        $
    116,497
        $
    116,497
     
    Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
    In thousands
       
    Fair value at issuance on December 10, 2018   $
    60,000
     
    Change in fair value    
    (2,082
    )
    Fair value at December 31, 2018   $
    57,918
     
    Schedule of Derivative Liabilities at Fair Value [Table Text Block]
    December 31,

    (In thousands)
      2018   2017
            (As Restated, Note 2)
    Equity-related derivative liabilities   $
    41,272
        $
    108,887
     
    Debt-related derivative liabilities    
    1,524
         
    7,610
     
    Total derivative liabilities   $
    42,796
        $
    116,497
     
    Fair Value, Net Derivative Asset (Liability) Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
    (in thousands)
      2018   2017
            (As Restated, Note 2)
    Balance at January 1   $
    116,497
        $
    4,135
     
    Additions    
    4,089
         
    133,517
     
    Loss from change in fair value of derivative liabilities    
    30,880
         
    48,852
     
    Derecognition to additional paid-in capital upon conversion or extinguishment    
    (108,670
    )    
    (70,007
    )
    Balance at December 31   $
    42,796
        $
    116,497
     
    Fair Value Measurement Inputs and Valuation Techniques [Table Text Block]
    December 31,
      2018   2017
    Risk-free interest rate  
    2.5%
    -
    3.0%
     
    1.7%
    -
    2.4%
    Risk-adjusted discount yield  
    17.2%
    -
    27.3%
     
    18.4%
    -
    28.5%
    Stock price volatility  
    45.0%
    -
    85.0%
     
    45.0%
    -
    80.0%
    Probability of change in control  
     
    0.0%
     
     
     
    5.0%
     
    Stock price  
     
    $3.34
     
     
     
    $3.75
     
    Credit spread  
    14.6%
    -
    24.9%
     
    16.6%
    -
    26.7%
    Estimated conversion dates  
    2019
    -
    2025
     
    2018
    -
    2025
    Fair Value of Consideration [Table Text Block]
    Element   Fair Value Allocation
    Manufacturing capacity reservation fee   $
    24,395
     
    Legal settlement and consent waiver    
    6,764
     
    Working capital adjustment    
    2,145
     
    Total fair value of consideration transferred   $
    33,304
     
    XML 109 R34.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 9 - Commitments and Contingencies (Tables)
    12 Months Ended
    Dec. 31, 2018
    Notes Tables  
    Schedule Of Future Minimum Payments For Lease Obligations [Table Text Block]
    Years Ending December 31

    (In thousands)
      Capital
    Leases
      Operating
    Leases
      Total Lease
    Obligations
    2019   $
    513
        $
    10,416
        $
    10,929
     
    2020    
    198
         
    7,932
         
    8,130
     
    2021    
    1
         
    7,226
         
    7,227
     
    2022    
         
    7,399
         
    7,399
     
    2023    
         
    3,034
         
    3,034
     
    Thereafter    
         
         
     
    Total future minimum payments    
    712
        $
    36,007
        $
    36,719
     
    Less: amount representing interest    
    (33
    )    
     
         
     
     
    Present value of minimum lease payments    
    679
         
     
         
     
     
    Less: current portion    
    (484
    )    
     
         
     
     
    Long-term portion   $
    195
         
     
         
     
     
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Fair Value Measurement (Details Textual) Details http://amyris.com/20181231/role/statement-note-4-fair-value-measurement-tables 53 false false R54.htm 053 - Disclosure - Note 4 - Fair Value Measurement - Fair Value, Assets, and Liabilities Measured on Recurring Basis (Details) Sheet http://amyris.com/20181231/role/statement-note-4-fair-value-measurement-fair-value-assets-and-liabilities-measured-on-recurring-basis-details Note 4 - Fair Value Measurement - Fair Value, Assets, and Liabilities Measured on Recurring Basis (Details) Details 54 false false R55.htm 054 - Disclosure - Note 4 - Fair Value Measurement - Convertible Debt (Details) Sheet http://amyris.com/20181231/role/statement-note-4-fair-value-measurement-convertible-debt-details Note 4 - Fair Value Measurement - Convertible Debt (Details) Details 55 false false R56.htm 055 - Disclosure - Note 4 - Fair Value Measurement - Derivative Instruments (Details) Sheet http://amyris.com/20181231/role/statement-note-4-fair-value-measurement-derivative-instruments-details Note 4 - 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Note 4 - Fair Value Measurement - Allocation of Consideration Fair Value (Details) Sheet http://amyris.com/20181231/role/statement-note-4-fair-value-measurement-allocation-of-consideration-fair-value-details Note 4 - Fair Value Measurement - Allocation of Consideration Fair Value (Details) Details 59 false false R60.htm 059 - Disclosure - Note 5 - Debt (Details Textual) Sheet http://amyris.com/20181231/role/statement-note-5-debt-details-textual Note 5 - Debt (Details Textual) Details http://amyris.com/20181231/role/statement-note-5-debt-tables 60 false false R61.htm 060 - Disclosure - Note 5 - Debt - Debt Components (Details) Sheet http://amyris.com/20181231/role/statement-note-5-debt-debt-components-details Note 5 - Debt - Debt Components (Details) Details 61 false false R62.htm 061 - Disclosure - Note 5 - Debt - Long-term Debt Instruments (Details) Sheet http://amyris.com/20181231/role/statement-note-5-debt-longterm-debt-instruments-details Note 5 - Debt - Long-term Debt Instruments (Details) Details 62 false false R63.htm 062 - Disclosure - Note 6 - Mezzanine Equity (Details Textual) Sheet http://amyris.com/20181231/role/statement-note-6-mezzanine-equity-details-textual Note 6 - Mezzanine Equity (Details Textual) Details http://amyris.com/20181231/role/statement-note-6-mezzanine-equity 63 false false R64.htm 063 - Disclosure - Note 7 - Stockholders' Deficit (Details Textual) Sheet http://amyris.com/20181231/role/statement-note-7-stockholders-deficit-details-textual Note 7 - Stockholders' Deficit (Details Textual) Details http://amyris.com/20181231/role/statement-note-7-stockholders-deficit-tables 64 false false R65.htm 064 - Disclosure - Note 7 - Stockholders' Deficit - Warrant Activity (Details) Sheet http://amyris.com/20181231/role/statement-note-7-stockholders-deficit-warrant-activity-details Note 7 - Stockholders' Deficit - Warrant Activity (Details) Details 65 false false R66.htm 065 - Disclosure - Note 7 - Stockholders' Deficit - Number of Callable Shares (Details) Sheet http://amyris.com/20181231/role/statement-note-7-stockholders-deficit-number-of-callable-shares-details Note 7 - Stockholders' Deficit - Number of Callable Shares (Details) Details 66 false false R67.htm 066 - Disclosure - Note 8 - Net Loss Per Share Attributable to Common Stockholders - Calculation of Basic and Diluted Net Loss Per Share of Common Stock (Details) Sheet http://amyris.com/20181231/role/statement-note-8-net-loss-per-share-attributable-to-common-stockholders-calculation-of-basic-and-diluted-net-loss-per-share-of-common-stock-details Note 8 - Net Loss Per Share Attributable to Common Stockholders - Calculation of Basic and Diluted Net Loss Per Share of Common Stock (Details) Details 67 false false R68.htm 067 - Disclosure - Note 8 - Net Loss Per Share Attributable to Common Stockholders - Antidilutive Securities Excluded From Computation of Earnings Per Share (Details) Sheet http://amyris.com/20181231/role/statement-note-8-net-loss-per-share-attributable-to-common-stockholders-antidilutive-securities-excluded-from-computation-of-earnings-per-share-details Note 8 - Net Loss Per Share Attributable to Common Stockholders - Antidilutive Securities Excluded From Computation of Earnings Per Share (Details) Details 68 false false R69.htm 068 - Disclosure - Note 9 - Commitments and Contingencies (Details Textual) Sheet http://amyris.com/20181231/role/statement-note-9-commitments-and-contingencies-details-textual Note 9 - Commitments and Contingencies (Details Textual) Details http://amyris.com/20181231/role/statement-note-9-commitments-and-contingencies-tables 69 false false R70.htm 069 - Disclosure - Note 9 - Commitments and Contingencies - Future Minimum Payments for Lease Obligations (Details) Sheet http://amyris.com/20181231/role/statement-note-9-commitments-and-contingencies-future-minimum-payments-for-lease-obligations-details Note 9 - Commitments and Contingencies - Future Minimum Payments for Lease Obligations (Details) Details 70 false false R71.htm 070 - Disclosure - Note 10 - Revenue Recognition 1 (Details Textual) Sheet http://amyris.com/20181231/role/statement-note-10-revenue-recognition-1-details-textual Note 10 - Revenue Recognition 1 (Details Textual) Details http://amyris.com/20181231/role/statement-note-10-revenue-recognition-tables 71 false false R72.htm 071 - Disclosure - Note 10 - Revenue Recognition 2 (Details Textual) Sheet http://amyris.com/20181231/role/statement-note-10-revenue-recognition-2-details-textual Note 10 - Revenue Recognition 2 (Details Textual) Details http://amyris.com/20181231/role/statement-note-10-revenue-recognition-tables 72 false false R73.htm 072 - Disclosure - Note 10 - Revenue Recognition - Disaggregation of Revenue (Details) Sheet http://amyris.com/20181231/role/statement-note-10-revenue-recognition-disaggregation-of-revenue-details Note 10 - Revenue Recognition - Disaggregation of Revenue (Details) Details 73 false false R74.htm 073 - Disclosure - Note 10 - Revenue Recognition - Revenue in Connection With Significant Revenue Agreement (Details) Sheet http://amyris.com/20181231/role/statement-note-10-revenue-recognition-revenue-in-connection-with-significant-revenue-agreement-details Note 10 - Revenue Recognition - Revenue in Connection With Significant Revenue Agreement (Details) Details 74 false false R75.htm 074 - Disclosure - Note 10 - Revenue Recognition - Contract Balances (Details) Sheet http://amyris.com/20181231/role/statement-note-10-revenue-recognition-contract-balances-details Note 10 - Revenue Recognition - Contract Balances (Details) Details 75 false false R76.htm 075 - Disclosure - Note 10 - Revenue Recognition - Remaining Performance Obligations (Details) Sheet http://amyris.com/20181231/role/statement-note-10-revenue-recognition-remaining-performance-obligations-details Note 10 - Revenue Recognition - Remaining Performance Obligations (Details) Details 76 false false R77.htm 076 - Disclosure - Note 10 - Revenue Recognition - Remaining Performance Obligations 2 (Details) Sheet http://amyris.com/20181231/role/statement-note-10-revenue-recognition-remaining-performance-obligations-2-details Note 10 - Revenue Recognition - Remaining Performance Obligations 2 (Details) Details 77 false false R78.htm 077 - Disclosure - Note 11 - Related Party Transactions (Details Textual) Sheet http://amyris.com/20181231/role/statement-note-11-related-party-transactions-details-textual Note 11 - Related Party Transactions (Details Textual) Details http://amyris.com/20181231/role/statement-note-11-related-party-transactions-tables 78 false false R79.htm 078 - Disclosure - Note 11 - Related Party Transactions - Related Party Debt (Details) Sheet http://amyris.com/20181231/role/statement-note-11-related-party-transactions-related-party-debt-details Note 11 - Related Party Transactions - Related Party Debt (Details) Details 79 false false R80.htm 079 - Disclosure - Note 11 - Related Party Transactions - Related Party Revenues (Details) Sheet http://amyris.com/20181231/role/statement-note-11-related-party-transactions-related-party-revenues-details Note 11 - Related Party Transactions - Related Party Revenues (Details) Details 80 false false R81.htm 080 - Disclosure - Note 11 - Related Party Transactions - Related Party Accounts Receivable (Details) Sheet http://amyris.com/20181231/role/statement-note-11-related-party-transactions-related-party-accounts-receivable-details Note 11 - Related Party Transactions - Related Party Accounts Receivable (Details) Details 81 false false R82.htm 081 - Disclosure - Note 11 - Related Party Transactions - Aprinnova JV's Assets and Liabilities (Details) Sheet http://amyris.com/20181231/role/statement-note-11-related-party-transactions-aprinnova-jvs-assets-and-liabilities-details Note 11 - Related Party Transactions - Aprinnova JV's Assets and Liabilities (Details) Details 82 false false R83.htm 082 - Disclosure - Note 12 - Stock-based Compensation (Details Textual) Sheet http://amyris.com/20181231/role/statement-note-12-stockbased-compensation-details-textual Note 12 - Stock-based Compensation (Details Textual) Details http://amyris.com/20181231/role/statement-note-12-stockbased-compensation-tables 83 false false R84.htm 083 - Disclosure - Note 12 - Stock-based Compensation - Employee Service Share-based Compensation, Allocation of Recognized Period Costs (Details) Sheet http://amyris.com/20181231/role/statement-note-12-stockbased-compensation-employee-service-sharebased-compensation-allocation-of-recognized-period-costs-details Note 12 - Stock-based Compensation - Employee Service Share-based Compensation, Allocation of Recognized Period Costs (Details) Details 84 false false R85.htm 084 - Disclosure - Note 12 - Stock-based Compensation - Share-based Payment Award, Stock Options with Performance, Valuation Assumptions (Details) Sheet http://amyris.com/20181231/role/statement-note-12-stockbased-compensation-sharebased-payment-award-stock-options-with-performance-valuation-assumptions-details Note 12 - Stock-based Compensation - Share-based Payment Award, Stock Options with Performance, Valuation Assumptions (Details) Details 85 false false R86.htm 085 - Disclosure - Note 12 - Stock-based Compensation - Options Activity (Details) Sheet http://amyris.com/20181231/role/statement-note-12-stockbased-compensation-options-activity-details Note 12 - Stock-based Compensation - Options Activity (Details) Details 86 false false R87.htm 086 - Disclosure - Note 12 - Stock-based Compensation - Share-based Payment Award, Stock Options, Valuation Assumptions (Details) Sheet http://amyris.com/20181231/role/statement-note-12-stockbased-compensation-sharebased-payment-award-stock-options-valuation-assumptions-details Note 12 - Stock-based Compensation - Share-based Payment Award, Stock Options, Valuation Assumptions (Details) Details 87 false false R88.htm 087 - Disclosure - Note 12 - Stock-based Compensation - Share-based Compensation, Stock Options and Stock Appreciation Rights Award Activity (Details) Sheet http://amyris.com/20181231/role/statement-note-12-stockbased-compensation-sharebased-compensation-stock-options-and-stock-appreciation-rights-award-activity-details Note 12 - Stock-based Compensation - Share-based Compensation, Stock Options and Stock Appreciation Rights Award Activity (Details) Details 88 false false R89.htm 088 - Disclosure - Note 12 - Stock-based Compensation - Temporal Display of Share-based Compensation, Restricted Stock and Restricted Stock Units Activity (Details) Sheet http://amyris.com/20181231/role/statement-note-12-stockbased-compensation-temporal-display-of-sharebased-compensation-restricted-stock-and-restricted-stock-units-activity-details Note 12 - Stock-based Compensation - Temporal Display of Share-based Compensation, Restricted Stock and Restricted Stock Units Activity (Details) Details 89 false false R90.htm 089 - Disclosure - Note 13 - Divestiture (Details Textual) Sheet http://amyris.com/20181231/role/statement-note-13-divestiture-details-textual Note 13 - Divestiture (Details Textual) Details http://amyris.com/20181231/role/statement-note-13-divestiture 90 false false R91.htm 090 - Disclosure - Note 14 - Income Taxes (Details Textual) Sheet http://amyris.com/20181231/role/statement-note-14-income-taxes-details-textual Note 14 - Income Taxes (Details Textual) Details http://amyris.com/20181231/role/statement-note-14-income-taxes-tables 91 false false R92.htm 091 - Disclosure - Note 14 - Income Taxes - Components of Income Loss (Details) Sheet http://amyris.com/20181231/role/statement-note-14-income-taxes-components-of-income-loss-details Note 14 - Income Taxes - Components of Income Loss (Details) Details 92 false false R93.htm 092 - Disclosure - Note 14 - Income Taxes - Components of Benefit (Provision) (Details) Sheet http://amyris.com/20181231/role/statement-note-14-income-taxes-components-of-benefit-provision-details Note 14 - Income Taxes - Components of Benefit (Provision) (Details) Details 93 false false R94.htm 093 - Disclosure - Note 14 - Income Taxes - Effective Tax Rate Reconciliation (Details) Sheet http://amyris.com/20181231/role/statement-note-14-income-taxes-effective-tax-rate-reconciliation-details Note 14 - Income Taxes - Effective Tax Rate Reconciliation (Details) Details 94 false false R95.htm 094 - Disclosure - Note 14 - Income Taxes - Deferred Tax Assets and Liabilities (Details) Sheet http://amyris.com/20181231/role/statement-note-14-income-taxes-deferred-tax-assets-and-liabilities-details Note 14 - Income Taxes - Deferred Tax Assets and Liabilities (Details) Details 95 false false R96.htm 095 - Disclosure - Note 14 - Income Taxes - Activity in the Deferred Tax Assets Valuation Allowance (Details) Sheet http://amyris.com/20181231/role/statement-note-14-income-taxes-activity-in-the-deferred-tax-assets-valuation-allowance-details Note 14 - Income Taxes - Activity in the Deferred Tax Assets Valuation Allowance (Details) Details 96 false false R97.htm 096 - Disclosure - Note 14 - Income Taxes - Uncertain Tax Benefits (Details) Sheet http://amyris.com/20181231/role/statement-note-14-income-taxes-uncertain-tax-benefits-details Note 14 - Income Taxes - Uncertain Tax Benefits (Details) Details 97 false false R98.htm 097 - Disclosure - Note 15 - Geographical Information - Long-lived Assets by Geography (Details) Sheet http://amyris.com/20181231/role/statement-note-15-geographical-information-longlived-assets-by-geography-details Note 15 - Geographical Information - Long-lived Assets by Geography (Details) Details 98 false false R99.htm 098 - Disclosure - Note 16 - Subsequent Events (Details Textual) Sheet http://amyris.com/20181231/role/statement-note-16-subsequent-events-details-textual Note 16 - Subsequent Events (Details Textual) Details http://amyris.com/20181231/role/statement-note-16-subsequent-events 99 false false All Reports Book All Reports amrs-20181231.xml amrs-20181231.xsd amrs-20181231_cal.xml amrs-20181231_def.xml amrs-20181231_lab.xml amrs-20181231_pre.xml http://xbrl.sec.gov/dei/2019-01-31 http://fasb.org/srt/2019-01-31 http://xbrl.sec.gov/country/2017-01-31 http://fasb.org/us-gaap/2019-01-31 true true XML 111 R38.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 14 - Income Taxes (Tables)
    12 Months Ended
    Dec. 31, 2018
    Notes Tables  
    Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
    Years Ended December 31,
    (In thousands)
      2018   2017
            (As Restated, Note 2)
    United States   $
    (218,109
    )   $
    (156,020
    )
    Foreign    
    (12,125
    )    
    6,915
     
    Loss before income taxes   $
    (230,234
    )   $
    (149,105
    )
    Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]
    Years Ended December 31,
    (In thousands)
      2018   2017
                 
    (As Restated, Note 2)
     
    Current:                
    Federal   $
        $
    6,564
     
    State    
         
    18
     
    Foreign    
         
    964
     
    Total current provision    
         
    7,546
     
    Deferred:                
    Federal    
         
    (669
    )
    State    
         
     
    Foreign    
         
     
    Total deferred benefit    
         
    (669
    )
    Total provision for income taxes$   $
        $
    6,877
     
    Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
    Years Ended December 31,
      2018   2017
            (As Restated, Note 2)
    Statutory tax rate    
    (21.0
    )%    
    (34.0
    )%
    State taxes, net of federal tax benefit    
    %    
    %
    Stock-based compensation    
    %    
    %
    Federal R&D credit    
    (0.6
    )%    
    (0.2
    )%
    Derivative liability    
    4.3
    %    
    13.9
    %
    Nondeductible interest    
    1.0
    %    
    3.0
    %
    Other    
    (0.1
    )%    
    (0.2
    )%
    Foreign losses    
    0.9
    %    
    8.5
    %
    Change in U.S. federal tax rate    
    %    
    25.1
    %
    IRC Section 382 limitation    
    %    
    7.2
    %
    Change in valuation allowance    
    15.5
    %    
    (18.6
    )%
    Effective income tax rate    
    %    
    4.7
    %
    Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
    December 31,
    (In thousands)
      2018   2017
            (As Restated, Note 2)
    Net operating loss carryforwards   $
    57,921
        $
    20,066
     
    Property, plant and equipment    
    9,269
         
    9,653
     
    Research and development credits    
    12,046
         
    9,480
     
    Foreign tax credit    
         
     
    Accruals and reserves    
    8,526
         
    7,286
     
    Stock-based compensation    
    6,496
         
    5,471
     
    Disallowed interest carryforward    
    2,359
         
     
    Capitalized start-up costs    
         
     
    Capitalized research and development costs    
    27,888
         
    32,085
     
    Intangible and others    
    3,114
         
    3,584
     
    Equity investments    
    156
         
     
    Total deferred tax assets    
    127,775
         
    87,625
     
    Debt discount and derivatives    
    (3,750
    )    
    (6,539
    )
    Total deferred tax liabilities    
    (3,750
    )    
    (6,539
    )
    Net deferred tax assets prior to valuation allowance    
    124,025
         
    81,086
     
    Less: valuation allowance    
    (124,025
    )    
    (81,086
    )
    Net deferred tax assets   $
        $
     
    Summary of Valuation Allowance [Table Text Block]
    (In thousands)
      Balance at Beginning
    of Year
      Additions   Reductions /
    Charges
      Balance at
    End of Year
    Deferred tax assets valuation allowance:                                
    Year Ended December 31, 2018   $
    81,086
        $
    42,939
        $
        $
    124,025
     
    Year Ended December 31, 2017 (As Restated, Note 2)   $
    386,867
        $
        $
    (305,781
    )   $
    81,086
     
    Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
    (In thousands)
       
    Balance at December 31, 2016   $
    9,101
     
    Increases in tax positions for prior period    
    50
     
    Increases in tax positions during current period    
    19,682
     
    Balance at December 31, 2017    
    28,833
     
    Increases in tax positions for prior period    
    55
     
    Increases in tax positions during current period    
    1,239
     
    Balance at December 31, 2018   $
    30,127
     
    XML 112 R17.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 8 - Net Loss Per Share Attributable to Common Stockholders
    12 Months Ended
    Dec. 31, 2018
    Notes to Financial Statements  
    Earnings Per Share [Text Block]
    8.
    Net Loss per Share Attributable to Common Stockholders
     
    The Company computes net loss per share in accordance with ASC
    260,
    “Earnings per Share.” Basic net loss per share of common stock is computed by dividing the Company’s net loss attributable to Amyris, Inc. common stockholders by the weighted-average number of shares of common stock outstanding during the period. Diluted net loss per share of common stock is computed by giving effect to all potentially dilutive securities, including stock options, restricted stock units, convertible preferred stock, convertible promissory notes and common stock warrants, using the treasury stock method or the as converted method, as applicable. For the years ended
    December 
    31,
    2018
    and
    2017,
    basic net loss per share was the same as diluted net loss per share because the inclusion of all potentially dilutive securities outstanding was anti-dilutive. As such, the numerator and the denominator used in computing both basic and diluted net loss were the same for those years.
     
    The Company follows the
    two
    -class method when computing net loss per common share when shares are issued that meet the definition of participating securities. The
    two
    -class method requires income available to common stockholders for the period to be allocated between common stock and participating securities based upon their respective rights to receive dividends as if all income for the period had been distributed. The
    two
    -class method also requires losses for the period to be allocated between common stock and participating securities based on their respective rights if the participating security contractually participates in losses. The Company’s convertible preferred stock are participating securities as they contractually entitle the holders of such shares to participate in dividends and contractually require the holders of such shares to participate in the Company’s losses.
     
    The following table presents the calculation of basic and diluted net loss per share of common stock attributable to Amyris, Inc. common stockholders:
     
    Years Ended December 31,
    (In thousands, except shares and per share amounts)
      2018   2017
               
    (As Restated, Note 2)
    Net loss attributable to Amyris, Inc.    
    (230,235
    )    
    (155,982
    )
    Less deemed dividend related to beneficial conversion feature on Series A preferred stock    
         
    (562
    )
    Less deemed dividend related to beneficial conversion feature on Series B preferred stock    
         
    (634
    )
    Less deemed dividend related to beneficial conversion feature on Series D preferred stock    
         
    (5,757
    )
    Less deemed dividend upon settlement of make-whole provision on Series A preferred stock    
         
    (10,505
    )
    Less deemed dividend upon settlement of make-whole provision on Series B preferred stock    
         
    (22,632
    )
    Less deemed dividend related to the recognition of discounts on Series A preferred stock upon conversion    
         
    (21,578
    )
    Less deemed dividend related to the recognition of discounts on Series B preferred stock upon conversion    
         
    (24,366
    )
    Less deemed dividend related to proceeds discount upon conversion of Series D preferred stock    
    (6,852
    )    
     
    Add: losses allocated to participating securities    
    13,991
         
    40,159
     
    Net loss attributable to Amyris, Inc. common stockholders   $
    (223,096
    )   $
    (201,857
    )
                     
    Denominator:                
    Weighted-average shares of common stock outstanding used in computing net loss per share of common stock, basic and diluted    
    60,405,910
         
    32,253,570
     
    Basic and diluted loss per share   $
    (3.69
    )   $
    (6.26
    )
     
    The following outstanding shares of potentially dilutive securities were excluded from the computation of diluted net loss per share of common stock for the periods presented because including them would have been anti-dilutive:
     
    Years Ended December 31,   2018   2017
            (As Restated, Note 2)
    Period-end common stock warrants    
    25,986,370
         
    29,921,844
     
    Convertible promissory notes (1)    
    13,703,162
         
    8,203,821
     
    Period-end stock options to purchase common stock    
    5,392,269
         
    1,338,367
     
    Period-end restricted stock units    
    5,294,848
         
    685,007
     
    Period-end preferred shares on an as-converted basis    
    2,955,732
         
    4,504,212
     
    Total potentially dilutive securities excluded from computation of diluted net loss per share    
    53,332,381
         
    44,653,251
     
    ______________
     
    (
    1
    )
    The potentially dilutive effect of convertible promissory notes was computed based on conversion ratios in effect at the respective year-end. A portion of the convertible promissory notes issued carries a provision for a reduction in conversion price under certain circumstances, which could potentially increase the dilutive shares outstanding. Another portion of the convertible promissory notes issued carries a provision for an increase in the conversion rate under certain circumstances, which could also potentially increase the dilutive shares outstanding.
    XML 113 R13.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 4 - Fair Value Measurement
    12 Months Ended
    Dec. 31, 2018
    Notes to Financial Statements  
    Financial Instruments Disclosure [Text Block]
    4.
    Fair Value Measurement
     
    Assets and liabilities are measured and reported at fair value per related accounting standards that define fair value as the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. The fair value hierarchy prioritizes the inputs to valuation techniques used to measure fair value. An asset's or liability's level is based on the lowest level of input that is significant to the fair value measurement. Assets and liabilities carried at fair value are valued and disclosed in
    one
    of the following
    three
    levels of the valuation hierarchy:
     
        
    Level
    1:
    Quoted market prices in active markets for identical assets or liabilities.
        
    Level
    2:
    Observable market-based inputs or unobservable inputs that are corroborated by market data.
        
    Level
    3:
    Unobservable inputs that are
    not
    corroborated by market data.
     
    Assets and Liabilities Measured and Recorded at Fair Value on a Recurring Basis
     
    As of
    December 
    31,
    2018
    and
    2017,
    the Company’s financial assets and financial liabilities measured at fair value on a recurring basis were classified within the fair value hierarchy as follows:
     
    December 31,
    (In thousands)
      2018   2017 (As Restated, Note 2)
        Level 1   Level 2   Level 3   Total   Level 1   Level 2   Level 3   Total
    Assets                                
    Money market funds   $
         
        $
        $
        $
    53,199
        $
        $
        $
    53,199
     
    Certificates of deposit    
         
         
         
         
         
    4,153
         
         
    4,153
     
    Total assets measured and recorded at fair value   $
         
        $
        $
        $
    53,199
        $
    4,153
        $
        $
    57,352
     
    Liabilities                                                                
    6% Convertible Notes Due 2021   $
         
        $
    57,918
        $
    57,918
        $
        $
        $
        $
     
    Embedded derivatives in connection with the issuance of debt and equity instruments    
         
         
         
         
         
         
    723
         
    723
     
    Freestanding derivative instruments in connection with the issuance of equity instruments    
         
         
    42,796
         
    42,796
         
         
         
    115,774
         
    115,774
     
    Total liabilities measured and recorded at fair value   $
        $
        $
    100,714
        $
    100,714
        $
        $
        $
    116,497
        $
    116,497
     
     
    There were
    no
    transfers between the levels during
    2018
    or
    2017.
     
    The Company’s assessment of the significance of a particular input to the fair value measurement in its entirety requires management to make judgements and consider factors specific to the asset or liability. The fair values of money market funds and certificates of deposit are based on fair values of identical assets. The method of determining the fair value of compound embedded derivative liabilities is described subsequently in this note. Market risk associated with compound embedded derivative liabilities relates to the potential reduction in fair value and negative impact to future earnings from a decrease in interest rates.
     
    At
    December 
    31,
    2018
    and
    December 
    31,
    2017,
    the carrying value of certain financial instruments, such as cash equivalents, accounts receivable, prepaid expenses and other current assets, accounts payable and other current accrued liabilities, approximate fair value due to their relatively short maturities and low market interest rates, if applicable.
     
    Changes in fair value of derivative liabilities are presented as gains or losses in the consolidated statements of operations in the line captioned "Gain (loss) from change in fair value of derivative instruments".
     
    Changes in the fair value of debt that is accounted for at fair value are presented as gains or losses in the consolidated statements of operations in the line captioned "Gain (loss) from change in fair value of debt".
     
    6%
    Convertible Notes Due
    2021
     
    The Company issued
    $60.0
    million of
    6%
    Convertible Notes Due
    2021
    on
    December 10, 2018 (
    see Note
    5,
    "Debt" and “Subsequent Events” for details) and elected the fair value option of accounting for this instrument. At
    December 
    31,
    2018,
    outstanding principal was
    $60.0
    million, and the fair value was
    $57.9
    million, which was measured using a binomial lattice model and assuming a
    25.2%
    discount yield,
    45%
    equity volatility,
    50%
    /
    50%
    probability of principal repayment in cash / stock, and
    5%
    probability of change in control. The Company assumed that if a change of control event were to occur, it would occur at the end of the calendar year. See Note
    5,
    “Debt” and Part II, Item
    8,
    “Subsequent Events” for further information related to this debt instrument. For the year ended
    December 
    31,
    2018,
    the Company recorded a
    $2.1
    million gain from change in fair value of debt in connection with the
    6%
    Convertible Notes Due
    2021,
    as follows:
     
    In thousands
       
    Fair value at issuance on December 10, 2018   $
    60,000
     
    Change in fair value    
    (2,082
    )
    Fair value at December 31, 2018   $
    57,918
     
     
    Derivative Instruments
     
    Derivative instruments measured at fair value on a recurring basis as of
    December 
    31,
    2018
    and
    2017
    are as follows:
     
    December 31,

    (In thousands)
      2018   2017
            (As Restated, Note 2)
    Equity-related derivative liabilities   $
    41,272
        $
    108,887
     
    Debt-related derivative liabilities    
    1,524
         
    7,610
     
    Total derivative liabilities   $
    42,796
        $
    116,497
     
     
    The following table provides a reconciliation of the beginning and ending liability balances associated with derivative liabilities – either freestanding or compound embedded – measured at fair value using significant unobservable inputs (Level
    3
    ):
     
     
    (in thousands)
      2018   2017
            (As Restated, Note 2)
    Balance at January 1   $
    116,497
        $
    4,135
     
    Additions    
    4,089
         
    133,517
     
    Loss from change in fair value of derivative liabilities    
    30,880
         
    48,852
     
    Derecognition to additional paid-in capital upon conversion or extinguishment    
    (108,670
    )    
    (70,007
    )
    Balance at December 31   $
    42,796
        $
    116,497
     
     
    The liabilities associated with freestanding and compound embedded derivatives represent the fair value of the equity conversion options, make-whole provisions, down round conversion price or conversion rate adjustment provisions and antidilution provisions in some of the Company's debt, preferred stock, cash warrants and antidilution warrants; see Note
    5,
    "Debt", and Note
    7,
    "Stockholders' Deficit". There is
    no
    current observable market for these types of derivatives and, as such, the Company determined the fair value of the freestanding or embedded derivatives using the Monte Carlo or binomial lattice models.
     
    A binomial lattice model was used to determine if a convertible note or share of convertible preferred stock would be converted, called or held at each decision point. Within the lattice model, the following assumptions are made: (i) the convertible note or share of convertible preferred stock will be converted early if the conversion value is greater than the holding value and (ii) the convertible note or share of convertible preferred stock will be called if the holding value is greater than both (a) redemption price and (b) the conversion value at the time. If the convertible note or share of convertible preferred stock is called, the holder will maximize their value by finding the optimal decision between (
    1
    ) redeeming at the redemption price and (
    2
    ) converting the convertible note or share of convertible preferred stock. Using this lattice method, the Company valued the embedded and freestanding derivatives using the "with-and-without method", where the fair value of each related convertible note or share of convertible preferred stock including the embedded derivative is defined as the "with", and the fair value of the convertible note excluding the embedded derivatives is defined as the "without". This method estimates the fair value of the embedded and freestanding derivatives by looking at the difference in the values between each convertible note or share of convertible preferred stock with the embedded and freestanding derivatives and the fair value of such convertible note or share of convertible preferred stock without the embedded and freestanding derivatives. The lattice model uses the stock price, conversion price, maturity date, risk-free interest rate, estimated stock volatility and estimated credit spread. The Company marks the compound embedded derivatives to market due to the conversion price
    not
    being indexed to the Company's own stock.
     
    The Company used a Monte Carlo simulation valuation model to determine the fair value of the
    May 2017
    and
    August 2017
    Cash and Dilution Warrants. Monte Carlo simulation combines a random number generator based on a probability distribution and additional inputs of volatility, time to expiration to generate a stock price and other uncertainties. The generated stock price at the time of expiration is then used to calculate the value of the option. The model then calculates results tens of thousands of times, each time using a different set of random values from the probability functions. The resulting Monte Carlo simulation valuation is based on the average of all the calculated results.
     
    The market-based assumptions and estimates used in valuing the compound embedded and freestanding derivative liabilities include amounts in the following ranges/amounts:
     
    December 31,
      2018   2017
    Risk-free interest rate  
    2.5%
    -
    3.0%
     
    1.7%
    -
    2.4%
    Risk-adjusted discount yield  
    17.2%
    -
    27.3%
     
    18.4%
    -
    28.5%
    Stock price volatility  
    45.0%
    -
    85.0%
     
    45.0%
    -
    80.0%
    Probability of change in control  
     
    0.0%
     
     
     
    5.0%
     
    Stock price  
     
    $3.34
     
     
     
    $3.75
     
    Credit spread  
    14.6%
    -
    24.9%
     
    16.6%
    -
    26.7%
    Estimated conversion dates  
    2019
    -
    2025
     
    2018
    -
    2025
     
    Changes in valuation assumptions can have a significant impact on the valuation of the embedded and freestanding derivative liabilities and debt that the Company elects to account for at fair value. For example, all other things being equal, a decrease/increase in the Company’s stock price, probability of change of control, credit spread, term to maturity/conversion or stock price volatility decreases/increases the valuation of the liabilities, whereas a decrease/increase in risk adjusted yields or risk-free interest rates increases/decreases the valuation of the liabilities. Certain of the convertible notes, shares of convertible preferred stock and warrants also include conversion or exercise price adjustment features and, for example, certain issuances of common stock by the Company at prices lower than the current conversion or exercise price result in a reduction of the conversion price of such notes or convertible preferred stock, or a reduction in the exercise price of, or an increase in the number of shares subject to, such warrants, which increases the value of the embedded and freestanding derivative liabilities and debt measured at fair value; see Note
    5,
    "Debt" for details.
     
    The Series A Preferred Stock issued in
    May 2017
    and Series B Preferred Stock issued in
    May 2017 (
    see Note
    7,
    “Stockholder’s Deficit”) included make-whole provisions, which are accounted for as embedded derivatives through the
    July 2017
    Shareholder Approval date at which time the make-whole provision became settleable for a fixed number of common stock shares and ceased to be accounted for as a derivative liability. Cash and antidilution warrants, classified as freestanding financial instruments, were also issued in conjunction with the
    May 2017
    Offering,
    August 2017
    DSM Offering and
    August 2017
    Vivo Offering and are classified as derivative liabilities. The total derivative liability recorded for the securities issued in connection with the
    May 2017
    Offering,
    August 2017
    DSM Offering and
    August 2017
    Vivo Offering was
    $113.1
    million.
     
    In
    June 2012,
    the Company entered into a cross-currency interest rate swap arrangement with Banco Pine with respect to the repayment of
    R$22.0
    million (approximately U.S.
    $6.6
    million based on the exchange rate as of
    December 
    31,
    2017
    ) of the Banco Pine Note. The swap arrangement exchanged the principal and interest payments under the Banco Pine Note (see Note
    4,
    "Debt") for alternative principal and interest payments that are subject to adjustment based on fluctuations in the foreign currency exchange rate between the U.S. dollar and Brazilian real. The swap had a fixed interest rate of
    3.94%.
    Changes in the fair value of the swap were recognized in the consolidated statements of operations, in “Gain (loss) from change in fair value of derivative instruments". As of
    December 
    31,
    2017,
    the balances of the loan and the associated cross-currency interest rate swap were zero.
     
    Assets and Liabilities Recorded at Carrying Value
     
    Financial Assets and Liabilities
     
    The carrying amounts of certain financial instruments, such as cash equivalents, accounts receivable, accounts payable and accrued liabilities, approximate fair value due to their relatively short maturities and low market interest rates, if applicable. Loans payable, credit facilities and convertible notes are recorded at carrying value (except for the
    6%
    Convertible Notes Due
    2021,
    which are recorded at fair value), which is representative of fair value at the date of acquisition. For loans payable and credit facilities recorded at carrying value, the Company estimates fair value using observable market-based inputs (Level
    2
    ); for convertible notes, the Company estimates fair value based on rates currently offered for instruments with similar maturities and terms (Level
    3
    ). The carrying amount (the total amount of net debt presented on the balance sheet) of the Company's debt at
    December 
    31,
    2018,
    excluding the
    6%
    Convertible Notes that the Company records at fair value, and at
    December 
    31,
    2017,
    was
    $151.7
    million and
    $165.4
    million, respectively. The fair value of such debt at
    December 
    31,
    2018
    and at
    December 
    31,
    2017
    was
    $149.3
    million and
    $156.9
    million, respectively, and was determined by (i) discounting expected cash flows using current market discount rates estimated for certain of the debt instruments and (ii) using
    third
    -party fair value estimates for the remaining debt instruments.
     
    Assets and Liabilities Measured and Recorded at Fair Value on a Non-Recurring Basis
     
    On
    November 19, 2018,
    the Company amended its supply agreement with DSM, as discussed in Note
    10,
    “Revenue Recognition” to secure production capacity at the Brotas facility in exchange for future cash payments totaling
    $22.7
    million, the issuance of
    1,643,991
    million shares common stock valued at
    $6.1
    million on the date of issuance and a further cash payment for the difference between the fair value of the common stock and
    $7.3
    million on
    March 29, 2019.
    In addition, the Company modified certain warrants held by DSM which resulted in the transfer of
    $2.9
    million of value to DSM and paid
    $1.8
    million to settle certain obligations to DSM related to the
    2017
    sale of the Brotas facility. The Company also entered into other transactions contemporaneously with the amended supply agreement as discussed in Note
    11,
    “Related Party Transactions” and Note
    16,
    “Subsequent Events”. This series of transactions with DSM in
    November 2018
    was accounted for as a combined transaction in which the Company determined and allocated the fair value of the consideration to each element. The fair value of the consideration transferred to DSM under the combined arrangement totaled
    $33.3
    million and was allocated as follows (in thousands):
     
    Element   Fair Value Allocation
    Manufacturing capacity reservation fee   $
    24,395
     
    Legal settlement and consent waiver    
    6,764
     
    Working capital adjustment    
    2,145
     
    Total fair value of consideration transferred   $
    33,304
     
     
    The fair value of these elements is based on Level
    3
    inputs, which considered the lowest level of input that is significant to the fair value measurement of these elements. To determine the fair value of the manufacturing capacity reservation fee, the Company used a discounted cash flow model under a cost savings valuation approach based on a competing manufacturing quote for similar capacity, location and timing. The Company used a discount rate of
    22.5%
    and a tax rate of
    0%
    to discount the gross cash flows. The fair value of the legal settlement for failure to obtain consent from DSM prior to executing the
    August 2018
    Vivo Warrant transaction and was determined by calculating the difference between the fair values of the warrants held by Vivo prior to and after the
    August 2018
    Vivo Warrant transaction using a combination of a Monte Carlo simulation and the Black-Scholes-Merton option pricing model. The fair value of the working capital adjustment was determined to equal the difference between the preliminary estimate for working capital upon closing the Brotas facility sale and the final working capital amounts transferred.
    XML 114 R82.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 11 - Related Party Transactions - Aprinnova JV's Assets and Liabilities (Details) - Aprinnova JV [Member] - Nikko [Member] - USD ($)
    $ in Thousands
    Dec. 31, 2018
    Dec. 31, 2017
    Assets $ 12,904 $ 7,635
    Liabilities $ 2,364 $ 3,187
    XML 115 R72.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 10 - Revenue Recognition 2 (Details Textual)
    Dec. 31, 2018
    Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2019-01-01  
    Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period 1 year
    Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2020-01-01  
    Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period 1 year
    Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2021-01-01  
    Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period 1 year
    Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2022-01-01  
    Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period 1 year
    XML 116 R76.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 10 - Revenue Recognition - Remaining Performance Obligations (Details)
    $ in Thousands
    Dec. 31, 2018
    USD ($)
    Revenue, Remaining Performance Obligation, Amount $ 22,056
    XML 117 R86.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 12 - Stock-based Compensation - Options Activity (Details) - USD ($)
    $ / shares in Units, $ in Thousands
    12 Months Ended
    Dec. 31, 2018
    Dec. 31, 2017
    Options granted (in shares) 4,337,119 661,094
    Weighted-average grant-date fair value per share (in dollars per share) $ 5.18 $ 3.26
    Allocated share-based compensation expense $ 9,190 $ 6,265
    Unrecognized compensation costs as of December 31 (in millions) 8,500 2,700
    Share-based Payment Arrangement, Option [Member]    
    Allocated share-based compensation expense $ 2,600 $ 3,300
    XML 118 R59.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 4 - Fair Value Measurement - Allocation of Consideration Fair Value (Details)
    $ in Thousands
    Nov. 19, 2018
    USD ($)
    Manufacturing capacity reservation fee $ 24,395
    Legal settlement and consent waiver 6,764
    Working capital adjustment 2,145
    Total fair value of consideration transferred $ 33,304
    XML 119 R55.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 4 - Fair Value Measurement - Convertible Debt (Details) - Long-term Debt [Member]
    $ in Thousands
    1 Months Ended
    Dec. 31, 2018
    USD ($)
    Fair value at issuance on December 10, 2018 $ 60,000
    Change in fair value (2,082)
    Fair value at December 31, 2018 $ 57,918
    XML 120 R51.htm IDEA: XBRL DOCUMENT v3.19.3
    Note 3 - Balance Sheet Details - Accrued and Other Current Liabilities (Details) - USD ($)
    $ in Thousands
    Dec. 31, 2018
    Dec. 31, 2017
    Payroll and related expenses $ 9,220 $ 7,238
    Contract termination fees 4,092
    Accrued interest 3,853 8,213
    Asset retirement obligation(1) [1] 3,063 3,587
    Ginkgo partnership payments obligation 2,155
    Tax-related liabilities 2,139 5,837
    Professional services 1,173 1,694
    Other 3,284 2,633
    Total accrued and other current liabilities $ 28,979 $ 29,202 [2]
    [1] The asset retirement obligation represents liabilities incurred but not yet discharged in connection with our 2013 abandonment of a partially constructed facility in Prad&#243;polis, Brazil.
    [2] Adjustment to accrued liability.

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Note 1 - Basis of Presentation and Summary of Significant Accounting Policies (Tables)
12 Months Ended
Dec. 31, 2018
Notes Tables  
Schedules of Concentration of Risk, by Risk Factor [Table Text Block]
As of December 31,   2018   2017
Customer B    
24
%    
10
%
Customer C    
19
%    
15
%
Customer G    
11
%    
**
Customer A (related party)    
**
     
38
%
Years Ended December 31,   2018   2017
        (As Restated, Note 2)
Customer A (related party)    
17
%    
46
%
Customer B    
18
%    
13
%
Customer C    
13
%    
**
 
Customer D    
13
%    
**
 
Customer E    
**
     
11
%
Customer F     **       **  
Schedule of New Accounting Pronouncements and Changes in Accounting Principles [Table Text Block]
    Year Ended December 31, 2018
(In thousands)   As Reported   Adjustments   Amounts Without the Adoption of ASC 606
Renewable products   $
33,598
    $
    $
33,598
 
Licenses and royalties    
7,658
     
5,094
     
12,752
 
Grants and collaborations    
22,348
     
(5,786
)    
16,562
 
Total revenue from all customers   $
63,604
    $
(692
)   $
62,912