X0303 4 2011-04-15 0 0001365916 AMYRIS, INC. AMRS 0001501911 Portela Mario C/O AMYRIS, INC. 5885 HOLLIS ST., SUITE 100 EMERYVILLE CA 94608 0 1 0 0 Chief Operating Officer Common Stock 2011-04-15 4 A 0 20000 0 A 20000 D Common Stock 2011-04-15 4 A 0 3301 0 A 23301 D Common Stock 2011-04-15 4 F 0 1389 26.84 D 21912 D Stock Option (Right to Buy) 26.84 2011-04-15 4 A 0 29000 0 A 2021-04-14 Common Stock 29000 29000 D Represents a restricted stock unit award that vests in 3 successive equal annual installments, with the first 1/3rd of the shares vesting on January 1, 2012. Represents a restricted stock unit award that is fully vested. The shares reported as disposed of in this Form 4 were relinquished by the Reporting Person and cancelled by the Issuer in exchange for the Issuer's agreement to pay federal and state tax withholding obligations of the Reporting Person resulting from the settlement of a restricted stock unit award granted on April 15, 2011 and reported in this Form 4. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes. The stock option vested as to 1/48th of the total number of shares subject to the option on February 1, 2011, and thereafter vested and shall vest as to 1/48th of the total number of shares subject to the option in equal monthly installments. /s/ Mario Portela by Jeryl Hilleman Attorney-in-Fact 2011-04-15