X0303 4 2009-12-10 0 0001096481 ANGIOTECH PHARMACEUTICALS INC ANPI 0001365619 Brege Laura C/O ONYX PHARMACEUTICALS, INC. 2100 POWELL STREET EMERYVILLE CA 94608 1 0 0 0 Stock Option with Tandem SAR 1.35 2009-12-10 4 A 0 12500 0 A 2010-01-01 2014-12-09 Common Stock 12500 42500 D The options will start to vest effective 1/1/2010 in equal monthly installments until 6/1/2010. Represents the number of the Company's common shares into which the stock options are convertible. In the event that the Reporting Person elects to exercise the tandem SAR, the stock option will be canceled and the Reporting Person will be entitled to receive a number of common shares with an aggregate value equal to the product of (a) the excess of the market price of a common share on the date of exercise over the exercise price of the tandem SAR, multiplied by (b) the number of tandem SARs exercised. /s/Jay Dent, Attorney-in-Fact 2009-12-14