X0306 4 2018-09-28 0 0001724344 Entasis Therapeutics Holdings Inc. ETTX 0001655827 Frazier Life Sciences VIII, L.P. 601 UNION STREET, SUITE 3200 SEATTLE WA 98101 0 0 1 0 0001698823 FHM LIFE SCIENCES VIII, L.L.C. 601 UNION STREET, SUITE 3200 SEATTLE WA 98101 0 0 1 0 0001365617 Heron Patrick J 601 UNION STREET, SUITE 3200 SEATTLE WA 98101 0 0 1 0 0001698755 FHM LIFE SCIENCES VIII, L.P. 601 UNION STREET, SUITE 3200 SEATTLE WA 98101 0 0 1 0 Common Stock 2018-09-28 4 C 0 337707 A 337707 D Common Stock 2018-09-28 4 C 0 251487 A 589194 D Common Stock 2018-09-28 4 C 0 320898 A 974066 D Common Stock 2018-09-28 4 P 0 375887 15.00 A 1349953 D Series B Convertible Preferred Stock 2018-09-28 4 C 0 7000000 0.00 D Common Stock 337707 0 D Series B-1 Tranche A Convertible Preferred Stock 2018-09-28 4 C 0 5212833 0.00 D Common Stock 251487 0 D Series B-1 Tranche B Convertible Preferred Stock 2018-09-28 4 C 0 6651574 0.00 D Common Stock 320898 0 D Each share of Series B Preferred Stock, Series B-1 Tranche A Convertible Preferred Stock and Series B-1 Tranche B Convertible Preferred Stock (collectively, the "Preferred Stock") automatically converted into Common Stock on a 20.728-for-one basis upon the closing of the Issuer's initial public offering. The Preferred Stock had no expiration date. The reportable securities are held directly by Frazier Life Sciences VIII, L.P. ("FLS LP"). FHM Life Sciences VIII, L.P. ("FHM LP") is the general partner of FLS LP. FHM Life Sciences VIII, L.L.C. ("FHM LLC") is the general partner of FHM LP. James Topper and Patrick Heron are the sole managing members of FHM LLC. Mr. Heron, FHM LP and FHM LLC disclaims beneficial ownership of the securities held by FLS LP except, to the extent of his or its pecuniary interest therein, if any. This number includes an aggregate of 63,974 shares of Common Stock received upon the conversion of the Issuer's Preferred Stock as payment of the accrued dividends through September 27, 2018. No dividends will accrue after September 27, 2018. Frazier Life Sciences VIII, L.P. By: FHM Life Sciences VIII, L.P. Its: general partner By FHM Life Sciences VIII, L.L.C. Its: general partner, By: /s/ Steve Bailey 2018-10-02 FHM Life Sciences VIII, L.L.C. By: /s/ Steve Bailey 2018-10-02 /s/ Steve Bailey, Attorney-in-Fact for Patrick J. Heron 2018-10-02 FHM Life Sciences VIII, L.P. By: FHM Life Sciences VIII, L.L.C. Its: general partner By: /s/ Steve Bailey 2018-10-02