<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2009-03-26</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001038223</issuerCik>
        <issuerName>CLARIENT, INC</issuerName>
        <issuerTradingSymbol>CLRT</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001199270</rptOwnerCik>
            <rptOwnerName>LAMONT ANN H</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O OAK INVESTMENT PARTNERS</rptOwnerStreet1>
            <rptOwnerStreet2>ONE GORHAM ISLAND</rptOwnerStreet2>
            <rptOwnerCity>WESTPORT</rptOwnerCity>
            <rptOwnerState>CT</rptOwnerState>
            <rptOwnerZipCode>06880</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001365607</rptOwnerCik>
            <rptOwnerName>OAK INVESTMENT PARTNERS XII L P</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE GORHAM ISLAND</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>WESTPORT</rptOwnerCity>
            <rptOwnerState>CT</rptOwnerState>
            <rptOwnerZipCode>06880</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Series A Convertible Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>1.90</value>
                <footnoteId id="F4"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F2"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <footnoteId id="F3"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Note</value>
                    <footnoteId id="F5"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The Series A Convertible Preferred Stock is immediately convertible.</footnote>
        <footnote id="F2">The conversion feature continues indefinitely.</footnote>
        <footnote id="F3">3,833,201 shares of Series A Convertible Preferred Stock convertible into 15,332,804 of Common Stock, subject to adjustment.</footnote>
        <footnote id="F4">Each share of Series A Convertible Preferred Stock, par value $0.01 per share, is initially convertible into 4 shares of Common Stock.</footnote>
        <footnote id="F5">Represents shares directly owned by Oak Investment Partners XII, L.P. (&quot;Oak XII, L.P.&quot;).  On March 25, 2009, Oak XII, L.P. entered into a stock purchase agreement with the Issuer (the &quot;Stock Purchase Agreement&quot;), in connection with the private placement of shares of the Issuer's Series A Convertible Preferred Stock.  Under the terms of the Stock Purchase Agreement, subject to the Issuer receiving the requisite shareholder approval, Oak XII, L.P. will purchase an aggregate of up to 5,263,158 shares of Series A Convertible Preferred Stock at $7.60 per share.</footnote>
    </footnotes>

    <remarks>Ann H. Lamont is a director of Clarient, Inc.  In addition, Ms. Lamont is a Managing Member of Oak Associates XII, LLC, the General Partner of Oak Investment Partners XII, Limited Partnership.

Each Reporting Person disclaims the existence of a &quot;group&quot; and disclaims beneficial ownership of any securities (except to the extent of such Reporting Person's pecuniary interest in such securities) other than any securities reported herein as being directly owned by such Reporting Person, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of any such securities for purposes of Section 16 or for any other purpose.</remarks>

    <ownerSignature>
        <signatureName>Ann H. Lamont</signatureName>
        <signatureDate>2009-04-01</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Ann H. Lamont, Managing Member of Oak Associates XII, L.L.C., the General Partner of Oak Investment Partners XII, Limited Partnership</signatureName>
        <signatureDate>2009-04-01</signatureDate>
    </ownerSignature>
</ownershipDocument>
