<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13G</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: Amtrust Financial Services, Inc. -->
          <cik>0001365555</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <securitiesClassTitle>Common Stock, $0.0001 par value</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>04/09/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001690080</issuerCik>
        <issuerName>180 Life Sciences Corp.</issuerName>
        <issuerCusip>68236V302</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>3000 EL CAMINO REAL, BLDG 4, STE 200</com:street1>
          <com:city>Palo Alto</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94306</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>AMTRUST FINANCIAL SERVICES, INC.</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>509707.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>509707.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>509707.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>9.8</classPercent>
      <typeOfReportingPerson>CO</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>AMTRUST INTERNATIONAL UNDERWRITERS DAC</reportingPersonName>
      <citizenshipOrOrganization>L2</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>509707.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>509707.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>509707.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>9.8</classPercent>
      <typeOfReportingPerson>IC</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>180 Life Sciences Corp.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>3000 EL CAMINO REAL, BLDG 4, STE 200 Palo Alto, CA, 94306</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>The persons filing this statement are AmTrust Financial Services, Inc. ("AFSI") and AmTrust International Underwriters DAC ("AIUDAC", together with AFSI, the "Reporting Persons"). AFSI has the sole voting and dispositive power with regard to 509,707 of the issuer's shares of common stock. AIUDAC is a subsidiary of AFSI.</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>The principal business address of the AFSI is 59 Maiden Lane, 43rd Floor, New York, NY 10038. The registered address of AIUDAC is 6-8 College Green, Dublin 2, D02 VP48.</principalBusinessOfficeOrResidenceAddress>
        <citizenship>AFSI is incorporated in Delaware. AIUDAC is incorporated in Ireland.</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>AFSI has the sole voting and dispositive power with regard to 509,707 of the issuer's shares of common stock and is acting as an advisor on behalf of AIUDAC. AIUDAC is a subsidiary of AFSI.</amountBeneficiallyOwned>
        <classPercent>As of April 9, 2025, the Reporting Persons may be deemed to beneficially own in the aggregate 509,707 of the issuer's shares of common stock, representing approximately 9.8% of the issuer's outstanding shares (based on 5,185,780, shares outstanding as of March 31, 2025, as disclosed in the issuer's Annual Report on Form 10-K for the year ended December 31, 2024.)</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>The information set forth on the cover pages hereto and Item 4(a) is hereby incorporated in its entirety herein.</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>The information set forth on the cover pages hereto and Item 4(a) is hereby incorporated in its entirety herein.</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>The information set forth on the cover pages hereto and Item 4(a) is hereby incorporated in its entirety herein.</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>The information set forth on the cover pages hereto and Item 4(a) is hereby incorporated in its entirety herein.</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
      </item10>
    </items>
    <exhibitInfo>99.1 - Joint Filing Agreement</exhibitInfo>
    <signatureInformation>
      <reportingPersonName>AMTRUST FINANCIAL SERVICES, INC.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Stephen Ungar</signature>
        <title>Executive Vice President, General Counsel</title>
        <date>04/16/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>AMTRUST INTERNATIONAL UNDERWRITERS DAC</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Peter Farrell</signature>
        <title>Company Director</title>
        <date>04/16/2025</date>
      </signatureDetails>
    </signatureInformation>
  </formData>

</edgarSubmission>
