Note 10 - Collaboration and License Agreements (Details)	3 Months Ended	9 Months Ended			12 Months Ended		3 Months Ended	12 Months Ended
	Sep. 30, 2013 Guarantee of Indebtedness of Others [Member] USD ($)	Sep. 30, 2013 Guarantee of Indebtedness of Others [Member] USD ($)	Sep. 30, 2013 Up Front Fee And Milestone Payment Arrangement [Member] Abbott [Member] USD ($)	Sep. 30, 2013 Up Front Fee And Milestone Payment Arrangement [Member] Takeda [Member] USD ($)	Dec. 31, 2012 Milestone Payment Arrangement [Member] Abbott [Member] USD ($)	Dec. 31, 2009 Milestone Payment Arrangement [Member] Abbott [Member] USD ($)	Jun. 30, 2013 Milestone Payment Arrangement [Member] Takeda [Member] USD ($)	Dec. 31, 2009 Up-front Payment Arrangement [Member] Abbott [Member] USD ($)	Sep. 30, 2013 Numab Agreement [Member] USD ($)	Sep. 30, 2013 Numab Agreement [Member] CHF	Sep. 30, 2011 Numab Agreement [Member] Maximum [Member] USD ($)	Sep. 30, 2011 Numab Agreement [Member] Maximum [Member] CHF
Note 10 - Collaboration and License Agreements (Details) [Line Items]
Revenue Recognition, Milestone Method, Revenue Recognized			$ 37,500,000	$ 160,000,000	$ 15,000,000	$ 12,500,000	$ 10,000,000	$ 10,000,000
Loans Pledged as Collateral									2,400,000	2,200,000	5,000,000	5,000,000
Loans Pledged as Collateral (in Francs)									2,400,000	2,200,000	5,000,000	5,000,000
Loans Pledged as Collateral, Amount Deposited (in Francs)										2,200,000
Debt Instrument, Face Amount (in Francs)										2,000,000
Loss Contingency Accrual, Provision	$ 153,000	$ 512,000