Note 8 - Related Party Transactions (Details) - Expenses Under Agreements With R-Tech (USD $) In Thousands, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2013	Sep. 30, 2012	Sep. 30, 2013	Sep. 30, 2012
Related Party Transaction [Line Items]
Expenses related to R-Tech	$ 3,283	$ 776	$ 8,342	$ 2,512
Clinical Supplies [Member]
Related Party Transaction [Line Items]
Expenses related to R-Tech	35	331	255	1,618
Other research and development services [Member]
Related Party Transaction [Line Items]
Expenses related to R-Tech	75	147	181	451
Commercial supplies [Member]
Related Party Transaction [Line Items]
Expenses related to R-Tech	$ 3,173	$ 298	$ 7,906	$ 443