<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001364719</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001526119</issuerCik>
      <issuerName>Verastem, Inc.</issuerName>
      <secFileNumber>001-35403</secFileNumber>
      <issuerAddress>
        <com:street1>117 KENDRICK STREET</com:street1>
        <com:street2>SUITE 500</com:street2>
        <com:city>NEEDHAM</com:city>
        <com:stateOrCountry>MA</com:stateOrCountry>
        <com:zipCode>02494</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(781) 292-4200</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Kauffman Michael</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Board Member</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Jefferies LLC</name>
        <address>
          <com:street1>520 Madison Ave</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10022</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>8550</noOfUnitsSold>
      <aggregateMarketValue>83875.50</aggregateMarketValue>
      <noOfUnitsOutstanding>67000000</noOfUnitsOutstanding>
      <approxSaleDate>11/21/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>06/18/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Grant</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Verastem, Inc</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>8333</amountOfSecuritiesAcquired>
      <paymentDate>06/18/2024</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>09/28/2018</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Grant</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Verstem Inc</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>217</amountOfSecuritiesAcquired>
      <paymentDate>09/28/2018</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>All Sales are to be made pursuant to a previously signed/adopted 10b5-1 Selling plan dated 06/11/2025, and all representations regarding material non-public information were made as of the adoption of the plan.</remarks>
    <noticeSignature>
      <noticeDate>11/21/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>06/11/2025</planAdoptionDate>
      </planAdoptionDates>
      <signature>Michael Kauffman</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
