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        <title>iRhythm Technologies Inc</title>
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          <isin value="US4500561067"/>
          <ticker value="IRTC"/>
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        <curCd>USD</curCd>
        <valUSD>49705.11000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>Beta Bionics Inc</name>
        <lei>N/A</lei>
        <title>Beta Bionics Inc</title>
        <cusip>08659B102</cusip>
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          <isin value="US08659B1026"/>
          <ticker value="BBNX"/>
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        <balance>551.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Guardant Health Inc</name>
        <lei>254900M8C3E5VC8BR186</lei>
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          <isin value="US40131M1099"/>
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        <assetCat>EC</assetCat>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Tandem Diabetes Care Inc</name>
        <lei>549300JEPFOD0K4D3I05</lei>
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          <isin value="US8753722037"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>QIAGEN NV</name>
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          <isin value="NL0015002CX3"/>
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        <assetCat>EC</assetCat>
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        <invCountry>NL</invCountry>

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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Privia Health Group Inc</name>
        <lei>N/A</lei>
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          <isin value="US74276R1023"/>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Twist Bioscience Corp</name>
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          <isin value="US90184D1000"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>MSILF Treasury Portfolio</name>
        <lei>549300D1XR6GP7EZ0T47</lei>
        <title>MSILF Treasury Portfolio</title>
        <cusip>61747C582</cusip>
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          <isin value="US61747C5821"/>
          <ticker value="MISXX"/>
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        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>QuidelOrtho Corp</name>
        <lei>549300YU8CMO9HF53113</lei>
        <title>QuidelOrtho Corp</title>
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          <isin value="US2197981051"/>
          <ticker value="QDEL"/>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Masimo Corp</name>
        <lei>549300Q4A8JK0PIYCU29</lei>
        <title>Masimo Corp</title>
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          <isin value="US5747951003"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Natera Inc</name>
        <lei>N/A</lei>
        <title>Natera Inc</title>
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          <isin value="US6323071042"/>
          <ticker value="NTRA"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>NeoGenomics Inc</name>
        <lei>N/A</lei>
        <title>NeoGenomics Inc</title>
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          <isin value="US64049M2098"/>
          <ticker value="NEO"/>
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        <assetCat>EC</assetCat>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>IQVIA Holdings Inc</name>
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        <cusip>46266C105</cusip>
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          <isin value="US46266C1053"/>
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        <assetCat>EC</assetCat>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Establishment Labs Holdings In</name>
        <lei>549300BCBQ714JNJ7V58</lei>
        <title>Establishment Labs Holdings Inc</title>
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          <isin value="VGG312491084"/>
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        <assetCat>EC</assetCat>
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        <invCountry>CR</invCountry>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>TransMedics Group Inc</name>
        <lei>549300060GVOSMWARH50</lei>
        <title>TransMedics Group Inc</title>
        <cusip>89377M109</cusip>
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          <ticker value="TMDX"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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          <isCashCollateral>N</isCashCollateral>
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        <name>Alphatec Holdings Inc</name>
        <lei>549300EZE8CQ8K65FS24</lei>
        <title>Alphatec Holdings Inc</title>
        <cusip>02081G201</cusip>
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          <ticker value="ATEC"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Intuitive Surgical Inc</name>
        <lei>54930052SRG011710797</lei>
        <title>Intuitive Surgical Inc</title>
        <cusip>46120E602</cusip>
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          <isin value="US46120E6023"/>
          <ticker value="ISRG"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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          <isCashCollateral>N</isCashCollateral>
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        <name>Adaptive Biotechnologies Corp</name>
        <lei>549300ZTF7OT1FW66Q96</lei>
        <title>Adaptive Biotechnologies Corp</title>
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          <ticker value="ADPT"/>
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        <name>Veeva Systems Inc</name>
        <lei>549300YZEXPDB92M2F02</lei>
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        <name>Hinge Health Inc</name>
        <lei>N/A</lei>
        <title>Hinge Health Inc</title>
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          <ticker value="HNGE"/>
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      <invstOrSec>
        <name>Schrodinger Inc/United States</name>
        <lei>984500044BAE4791E559</lei>
        <title>Schrodinger Inc/United States</title>
        <cusip>80810D103</cusip>
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          <ticker value="SDGR"/>
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        <assetCat>EC</assetCat>
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          <isCashCollateral>N</isCashCollateral>
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        <name>Hologic Inc</name>
        <lei>549300DYP6F5ZJL0LB74</lei>
        <title>Hologic Inc</title>
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        <assetCat>EC</assetCat>
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      <invstOrSec>
        <name>Veracyte Inc</name>
        <lei>529900ESWZRHXOW27Z37</lei>
        <title>Veracyte Inc</title>
        <cusip>92337F107</cusip>
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          <ticker value="VCYT"/>
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        <balance>707.00000000</balance>
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        <valUSD>24271.31000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
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      <invstOrSec>
        <name>Align Technology Inc</name>
        <lei>549300N5YSE0U3LCP840</lei>
        <title>Align Technology Inc</title>
        <cusip>016255101</cusip>
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          <isin value="US0162551016"/>
          <ticker value="ALGN"/>
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        <balance>736.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>92161.92000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>LifeStance Health Group Inc</name>
        <lei>N/A</lei>
        <title>LifeStance Health Group Inc</title>
        <cusip>53228F101</cusip>
        <identifiers>
          <isin value="US53228F1012"/>
          <ticker value="LFST"/>
        </identifiers>
        <balance>2257.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12413.50000000</valUSD>
        <pctVal>0.475569263515</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illumina Inc</name>
        <lei>SQ95QG8SR5Q56LSNF682</lei>
        <title>Illumina Inc</title>
        <cusip>452327109</cusip>
        <identifiers>
          <isin value="US4523271090"/>
          <ticker value="ILMN"/>
        </identifiers>
        <balance>1046.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>99338.62000000</valUSD>
        <pctVal>3.805727180247</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Insulet Corp</name>
        <lei>549300TZTYD2PYN92D43</lei>
        <title>Insulet Corp</title>
        <cusip>45784P101</cusip>
        <identifiers>
          <isin value="US45784P1012"/>
          <ticker value="PODD"/>
        </identifiers>
        <balance>308.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>95088.84000000</valUSD>
        <pctVal>3.642915342755</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Inspire Medical Systems Inc</name>
        <lei>549300XQQCQ7HCJKTW25</lei>
        <title>Inspire Medical Systems Inc</title>
        <cusip>457730109</cusip>
        <identifiers>
          <isin value="US4577301090"/>
          <ticker value="INSP"/>
        </identifiers>
        <balance>257.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19069.40000000</valUSD>
        <pctVal>0.730561124072</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Teladoc Health Inc</name>
        <lei>549300I2PVFBC9MFAC61</lei>
        <title>Teladoc Health Inc</title>
        <cusip>87918A105</cusip>
        <identifiers>
          <isin value="US87918A1051"/>
          <ticker value="TDOC"/>
        </identifiers>
        <balance>1978.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15289.94000000</valUSD>
        <pctVal>0.585767551858</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Progyny Inc</name>
        <lei>N/A</lei>
        <title>Progyny Inc</title>
        <cusip>74340E103</cusip>
        <identifiers>
          <isin value="US74340E1038"/>
          <ticker value="PGNY"/>
        </identifiers>
        <balance>677.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14569.04000000</valUSD>
        <pctVal>0.558149403707</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Globus Medical Inc</name>
        <lei>5299003M2P4CIK0RF205</lei>
        <title>Globus Medical Inc</title>
        <cusip>379577208</cusip>
        <identifiers>
          <isin value="US3795772082"/>
          <ticker value="GMED"/>
        </identifiers>
        <balance>1276.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>73076.52000000</valUSD>
        <pctVal>2.799609038276</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PROCEPT BioRobotics Corp</name>
        <lei>N/A</lei>
        <title>PROCEPT BioRobotics Corp</title>
        <cusip>74276L105</cusip>
        <identifiers>
          <isin value="US74276L1052"/>
          <ticker value="PRCT"/>
        </identifiers>
        <balance>538.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19201.22000000</valUSD>
        <pctVal>0.735611234058</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Oscar Health Inc</name>
        <lei>254900AE8KDLFDOPKZ19</lei>
        <title>Oscar Health Inc</title>
        <cusip>687793109</cusip>
        <identifiers>
          <isin value="US6877931096"/>
          <ticker value="OSCR"/>
        </identifiers>
        <balance>2466.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46681.38000000</valUSD>
        <pctVal>1.788394047324</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="Monthly returns presented in Item B.5(a) have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2025-11-24</ncom:dateSigned>
      <ncom:nameOfApplicant>First Trust Exchange-Traded Fund II</ncom:nameOfApplicant>
      <ncom:signature>Derek Maltbie</ncom:signature>
      <ncom:signerName>Derek Maltbie</ncom:signerName>
      <ncom:title>Treasurer, Chief Financial Officer and Chief Accounting Officer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
