<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2006-07-28</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001362984</issuerCik>
        <issuerName>Mid-America Bancshares, Inc.</issuerName>
        <issuerTradingSymbol>None</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001365432</rptOwnerCik>
            <rptOwnerName>Waldron David V</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O MID-AMERICA BANCSHARES, INC</rptOwnerStreet1>
            <rptOwnerStreet2>7651 HIGHWAY 70 SOUTH</rptOwnerStreet2>
            <rptOwnerCity>NASHVILLE</rptOwnerCity>
            <rptOwnerState>TN</rptOwnerState>
            <rptOwnerZipCode>37221</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <remarks>Presently, the Issuer has only 1,000 organizational shares
outstanding. Assuming completion of the proposed share exchange
among the Issuer, Bank of the South and PrimeTrust Bank, it is
anticipated that the Reporting Person will exchange his shares
of common stock of the target banks for an estimated 75,389
shares of common stock (directly attributable to him) and
23,799 shares of common stock (indirectly attributable to him)
of the Issuer and that he will be attributed with direct ownership
of stock options exercisable for 6,313 shares of the Issuer's
common stock.</remarks>

    <ownerSignature>
        <signatureName>/s/ David V. Waldron</signatureName>
        <signatureDate>2006-07-28</signatureDate>
    </ownerSignature>
</ownershipDocument>
