<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2020-10-27</periodOfReport>

    <notSubjectToSection16>true</notSubjectToSection16>

    <issuer>
        <issuerCik>0001822462</issuerCik>
        <issuerName>Foghorn Therapeutics Inc.</issuerName>
        <issuerTradingSymbol>FHTX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001362558</rptOwnerCik>
            <rptOwnerName>Abu Dhabi Investment Authority</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>211 CORNICHE STREET</rptOwnerStreet1>
            <rptOwnerStreet2>PO BOX 3600</rptOwnerStreet2>
            <rptOwnerCity>ABU DHABI</rptOwnerCity>
            <rptOwnerState>C0</rptOwnerState>
            <rptOwnerZipCode>0000</rptOwnerZipCode>
            <rptOwnerStateDescription>UNITED ARAB EMIRATES</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOther>true</isOther>
            <otherText>Former 10% Owner</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001790748</rptOwnerCik>
            <rptOwnerName>Platinum International Investment Holding RSC Ltd</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>26TH FLOOR, AL KHATEM TOWER, ADGM SQUARE</rptOwnerStreet1>
            <rptOwnerStreet2>PO BOX 25642, AL MARYAH ISLAND</rptOwnerStreet2>
            <rptOwnerCity>ABU DHABI</rptOwnerCity>
            <rptOwnerState>C0</rptOwnerState>
            <rptOwnerZipCode>NA</rptOwnerZipCode>
            <rptOwnerStateDescription>UNITED ARAB EMIRATES</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOther>true</isOther>
            <otherText>Former 10% Owner</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001790749</rptOwnerCik>
            <rptOwnerName>Platinum Falcon B 2018 RSC Ltd</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>26TH FLOOR, AL KHATEM TOWER, ADGM SQUARE</rptOwnerStreet1>
            <rptOwnerStreet2>PO BOX 25642, AL MARYAH ISLAND</rptOwnerStreet2>
            <rptOwnerCity>ABU DHABI</rptOwnerCity>
            <rptOwnerState>C0</rptOwnerState>
            <rptOwnerZipCode>NA</rptOwnerZipCode>
            <rptOwnerStateDescription>UNITED ARAB EMIRATES</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOther>true</isOther>
            <otherText>Former 10% Owner</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2020-10-27</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>C</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>1081081</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1081081</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F2"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2020-10-27</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>150000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>16</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1231081</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F3"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Series B Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2020-10-27</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>C</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>2000001</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F1"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1081081</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F2"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Upon the closing of the sale of shares of Common Stock of the Issuer to the public in a firm-commitment underwritten public offering pursuant to an effective registration statement under the Securities Act of 1933, as amended, resulting in at least $35,000,000 of gross proceeds to the Issuer, the Series B Preferred Stock converted automatically into Common Stock. Every 1.85 shares of Series B Preferred Stock converted into one share of Common Stock. There was no expiration date for the Series B Preferred Stock.</footnote>
        <footnote id="F2">Platinum Falcon B 2018 RSC Limited (&quot;Platinum Falcon&quot;) directly holds the Series B Preferred Stock and the shares of Common Stock received upon conversion of the Series B Preferred Stock. Platinum International Investment Holding RSC Limited (&quot;Platinum Holdings&quot;) is the sole owner of Platinum Falcon, and the Abu Dhabi Investment Authority (&quot;ADIA&quot; and, together with Platinum Falcon and Platinum Holdings, the &quot;Reporting Persons&quot;) is the sole owner of Platinum Holdings. Therefore, Platinum Holdings and ADIA may also be deemed to beneficially own the Series B Preferred Stock and the shares of Common Stock received upon conversion of the Series B Preferred Stock.</footnote>
        <footnote id="F3">Platinum Falcon directly acquired 143,540 shares of Common Stock. Platinum Holdings and ADIA may also be deemed to beneficially own such shares of Common Stock. ADIA acquired directly 6,460 shares of Common Stock, and Platinum Holdings and Platinum Falcon disclaim beneficial ownership of such shares.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Humaid Bin Butti Bin Humaid Bin Bishr AlMarri, Authorized Signatory of Abu Dhabi Investment Authority</signatureName>
        <signatureDate>2020-10-27</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Ahmed Mohamed Ghubash, Authorized Signatory of Abu Dhabi Investment Authority</signatureName>
        <signatureDate>2020-10-27</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Humaid Bin Butti Bin Humaid Bin Bishr AlMarri, Authorized Signatory of Platinum International Investment Holding RSC Limited</signatureName>
        <signatureDate>2020-10-27</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Ahmed Mohamed Ghubash, Authorized Signatory of Platinum International Investment Holding RSC Limited</signatureName>
        <signatureDate>2020-10-27</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Humaid Bin Butti Bin Humaid Bin Bishr AlMarri, Authorized Signatory of  Platinum Falcon B 2018 RSC Limited</signatureName>
        <signatureDate>2020-10-27</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Ahmed Mohamed Ghubash, Authorized Signatory of  Platinum Falcon B 2018 RSC Limited</signatureName>
        <signatureDate>2020-10-27</signatureDate>
    </ownerSignature>
</ownershipDocument>
