<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2020-10-22</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001822462</issuerCik>
        <issuerName>Foghorn Therapeutics Inc.</issuerName>
        <issuerTradingSymbol>FHTX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001362558</rptOwnerCik>
            <rptOwnerName>Abu Dhabi Investment Authority</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>211 CORNICHE STREET</rptOwnerStreet1>
            <rptOwnerStreet2>PO BOX 3600</rptOwnerStreet2>
            <rptOwnerCity>ABU DHABI</rptOwnerCity>
            <rptOwnerState>C0</rptOwnerState>
            <rptOwnerZipCode>0000</rptOwnerZipCode>
            <rptOwnerStateDescription>UNITED ARAB EMIRATES</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001790748</rptOwnerCik>
            <rptOwnerName>Platinum International Investment Holding RSC Ltd</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>26TH FLOOR, AL KHATEM TOWER, ADGM SQUARE</rptOwnerStreet1>
            <rptOwnerStreet2>PO BOX 25642, AL MARYAH ISLAND</rptOwnerStreet2>
            <rptOwnerCity>ABU DHABI</rptOwnerCity>
            <rptOwnerState>C0</rptOwnerState>
            <rptOwnerZipCode>NA</rptOwnerZipCode>
            <rptOwnerStateDescription>UNITED ARAB EMIRATES</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001790749</rptOwnerCik>
            <rptOwnerName>Platinum Falcon B 2018 RSC Ltd</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>26TH FLOOR, AL KHATEM TOWER, ADGM SQUARE</rptOwnerStreet1>
            <rptOwnerStreet2>PO BOX 25642, AL MARYAH ISLAND</rptOwnerStreet2>
            <rptOwnerCity>ABU DHABI</rptOwnerCity>
            <rptOwnerState>C0</rptOwnerState>
            <rptOwnerZipCode>NA</rptOwnerZipCode>
            <rptOwnerStateDescription>UNITED ARAB EMIRATES</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Series B Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F1"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1081081</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F2"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The Series B Preferred Stock is convertible (i) at any time at the option of the holder; (ii) automatically upon the closing of the sale of shares of Common Stock of the Issuer to the public in a firm-commitment underwritten public offering pursuant to an effective registration statement under the Securities Act of 1933, as amended, resulting in at least $35,000,000 of gross proceeds to the Issuer; or (iii) at the date and time specified by, or upon the occurrence of an event specified by, the holders of a majority of the then-outstanding shares of Preferred Stock of the Issuer (calculated on an as-converted-to-Common Stock basis), voting together as a single class. Every 1.85 shares of Series B Preferred Stock is convertible into one share of Common Stock, subject to the adjustments set forth in the Second Amended and Restated Certificate of Incorporation of the Issuer.</footnote>
        <footnote id="F2">Platinum Falcon B 2018 RSC Limited (&quot;Platinum Falcon&quot;) directly holds the Series B Preferred Stock. Platinum International Investment Holding RSC Limited (&quot;Platinum Holdings&quot;) is the sole owner of Platinum Falcon, and the Abu Dhabi Investment Authority (&quot;ADIA&quot; and, together with Platinum Falcon and Platinum Holdings, the &quot;Reporting Persons&quot;) is the sole owner of Platinum Holdings. Therefore, Platinum Holdings and ADIA may also be deemed to beneficially own the Series B Preferred Stock.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Humaid Bin Butti Bin Humaid Bin Bishr AlMarri, Authorized Signatory of Abu Dhabi Investment Authority</signatureName>
        <signatureDate>2020-10-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Ahmed Mohamed Ghubash, Authorized Signatory of Abu Dhabi Investment Authority</signatureName>
        <signatureDate>2020-10-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Humaid Bin Butti Bin Humaid Bin Bishr AlMarri, Authorized Signatory of Platinum International Investment Holding RSC Limited</signatureName>
        <signatureDate>2020-10-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Ahmed Mohamed Ghubash, Authorized Signatory of Platinum International Investment Holding RSC Limited</signatureName>
        <signatureDate>2020-10-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Humaid Bin Butti Bin Humaid Bin Bishr AlMarri, Authorized Signatory of  Platinum Falcon B 2018 RSC Limited</signatureName>
        <signatureDate>2020-10-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Ahmed Mohamed Ghubash, Authorized Signatory of  Platinum Falcon B 2018 RSC Limited</signatureName>
        <signatureDate>2020-10-22</signatureDate>
    </ownerSignature>
</ownershipDocument>
