0000950123-21-014773.txt : 20211112 0000950123-21-014773.hdr.sgml : 20211112 20211112080202 ACCESSION NUMBER: 0000950123-21-014773 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20210930 FILED AS OF DATE: 20211112 DATE AS OF CHANGE: 20211112 EFFECTIVENESS DATE: 20211112 FILER: COMPANY DATA: COMPANY CONFORMED NAME: PICTET ASSET MANAGEMENT SA CENTRAL INDEX KEY: 0001361570 IRS NUMBER: 000000000 STATE OF INCORPORATION: V8 FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-11884 FILM NUMBER: 211399718 BUSINESS ADDRESS: STREET 1: 60 ROUTE DE ACACIAS CITY: GENEVA 73 STATE: V8 ZIP: 1211 BUSINESS PHONE: 011 44 207 847 5040 MAIL ADDRESS: STREET 1: 60 ROUTE DE ACACIAS CITY: GENEVA 73 STATE: V8 ZIP: 1211 13F-HR 1 primary_doc.xml 13F-HR LIVE 0001361570 XXXXXXXX 09-30-2021 09-30-2021 false PICTET ASSET MANAGEMENT SA

60 route de Acacias Geneva 73 V8 1211

13F HOLDINGS REPORT 028-11884 N Karine Valtanen 00 41 58 323 1445 Karine Valtanen Geneva V8 11-10-2021 2 2727 90652186 false 1 28-11664 Pictet Asset Management Limited 2 28-21234 Pictet Asset Management (Europe) SA INFORMATION TABLE 2 7312.xml INFORMATION TABLE FOR FORM 13F 10X GENOMICS INC CL A COM 88025U109 7276 49979 SH DFND 1 0 0 10X GENOMICS INC CL A COM 88025U109 12784 87814 SH DFND 0 0 0 21VIANET GROUP INC SPONSORED ADS A 90138A103 83 4800 SH DFND 1 0 0 21VIANET GROUP INC SPONSORED ADS A 90138A103 60732 3508498 SH DFND 0 0 0 2U INC COM 90214J101 20930 623474 SH DFND 0 0 0 360 DIGITECH INC AMERICAN DEP 88557W101 2286 112500 SH DFND 0 0 0 3-D SYS CORP DEL COM NEW 88554D205 239 8684 SH DFND 0 0 0 3M CO COM 88579Y101 13875 79097 SH DFND 1 0 0 3M CO COM 88579Y101 126785 722749 SH DFND 0 0 0 51JOB INC SPONSORED ADS 316827104 2809 40400 SH DFND 0 0 0 ABBOTT LABS COM 002824100 13605 115167 SH DFND 1 0 0 ABBOTT LABS COM 002824100 180722 1529859 SH DFND 0 0 0 ABBVIE INC COM 00287Y109 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CHANNEL OUTDOOR HLDGS COM 18453H106 56 20775 SH DFND 0 0 0 CLEARWATER PAPER CORP COM 18538R103 628 16372 SH DFND 1 0 0 CLEARWATER PAPER CORP COM 18538R103 11371 296676 SH DFND 0 0 0 CLEVELAND-CLIFFS INC NEW COM 185899101 628 31680 SH DFND 0 0 0 CLOROX CO DEL COM 189054109 1565 9449 SH DFND 1 0 0 CLOROX CO DEL COM 189054109 55106 332748 SH DFND 0 0 0 CLOUDFLARE INC CL A COM 18915M107 1665 14784 SH DFND 1 0 0 CLOUDFLARE INC CL A COM 18915M107 7107 63088 SH DFND 0 0 0 CLOVER HEALTH INVESTMENTS CO COM CL A 18914F103 79 10685 SH DFND 0 0 0 CLOVIS ONCOLOGY INC COM 189464100 48 10800 SH DFND 0 0 0 CMC MATERIALS INC COM 12571T100 218 1770 SH DFND 0 0 0 CME GROUP INC COM 12572Q105 4847 25066 SH DFND 1 0 0 CME GROUP INC COM 12572Q105 71644 370481 SH DFND 0 0 0 CMS ENERGY CORP COM 125896100 1307 21874 SH DFND 1 0 0 CMS ENERGY CORP COM 125896100 327860 5489043 SH DFND 0 0 0 CNH INDL N V SHS N20944109 1685 98926 SH DFND 1 0 0 CNH INDL N V SHS N20944109 9384 550799 SH DFND 0 0 0 CNX RES CORP COM 12653C108 220 17400 SH DFND 0 0 0 COCA COLA CO COM 191216100 16742 319071 SH DFND 1 0 0 COCA COLA CO COM 191216100 111825 2131225 SH DFND 0 0 0 COCA-COLA EUROPACIFIC PARTNE SHS G25839104 1217 22084 SH DFND 1 0 0 COCA-COLA EUROPACIFIC PARTNE SHS G25839104 6398 116071 SH DFND 0 0 0 COEUR MNG INC COM NEW 192108504 108 17500 SH DFND 0 0 0 COGNEX CORP COM 192422103 802 10000 SH DFND 1 0 0 COGNEX CORP COM 192422103 4703 58630 SH DFND 0 0 0 COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 5929 79893 SH DFND 1 0 0 COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 47542 640643 SH DFND 0 0 0 COHERENT INC COM 192479103 439 1756 SH DFND 0 0 0 COHERUS BIOSCIENCES INC COM 19249H103 2548 158575 SH DFND 0 0 0 COLFAX CORP COM 194014106 372 8100 SH DFND 0 0 0 COLGATE PALMOLIVE CO COM 194162103 29753 393661 SH DFND 1 0 0 COLGATE PALMOLIVE CO COM 194162103 32868 434874 SH DFND 0 0 0 COLLIERS INTL GROUP INC SUB VTG SHS 194693107 296 2311 SH DFND 0 0 0 COLUMBIA BKG SYS INC COM 197236102 218 5727 SH DFND 0 0 0 COLUMBIA PPTY TR INC COM NEW 198287203 672 35364 SH DFND 1 0 0 COLUMBIA PPTY TR INC COM NEW 198287203 153 8023 SH DFND 0 0 0 COLUMBIA SPORTSWEAR CO COM 198516106 970 10119 SH DFND 1 0 0 COLUMBIA SPORTSWEAR CO COM 198516106 32582 339960 SH DFND 0 0 0 COMCAST CORP NEW CL A 20030N101 101886 1821671 SH DFND 1 0 0 COMCAST CORP NEW CL A 20030N101 349992 6257684 SH DFND 0 0 0 COMERICA INC COM 200340107 47 578 SH DFND 1 0 0 COMERICA INC COM 200340107 1462 18172 SH DFND 0 0 0 COMMERCE BANCSHARES INC COM 200525103 469 6724 SH DFND 0 0 0 COMMERCIAL METALS CO COM 201723103 256 8400 SH DFND 0 0 0 COMMSCOPE HLDG CO INC COM 20337X109 164 12076 SH DFND 0 0 0 COMMUNITY BK SYS INC COM 203607106 239 3492 SH DFND 0 0 0 COMMUNITY HEALTHCARE TR INC COM 20369C106 328 7266 SH DFND 1 0 0 COMMUNITY HEALTHCARE TR INC COM 20369C106 63 1392 SH DFND 0 0 0 COMMVAULT SYS INC COM 204166102 233 3100 SH DFND 0 0 0 COMPANHIA DE SANEAMENTO BASI SPONSORED ADR 20441A102 1647 232682 SH DFND 0 0 0 COMPANIA DE MINAS BUENAVENTU SPONSORED ADR 204448104 2879 422859 SH DFND 0 0 0 COMPUGEN LTD ORD M25722105 99 16538 SH DFND 0 0 0 COMSTOCK RES INC COM 205768302 112 10783 SH DFND 0 0 0 CONAGRA BRANDS INC COM 205887102 1140 33658 SH DFND 1 0 0 CONAGRA BRANDS INC COM 205887102 6481 191352 SH DFND 0 0 0 CONCENTRIX CORP COM 20602D101 496 2803 SH DFND 0 0 0 CONDUENT INC COM 206787103 81 12300 SH DFND 0 0 0 CONMED CORP COM 207410101 288 2200 SH DFND 0 0 0 CONOCOPHILLIPS COM 20825C104 28162 415555 SH DFND 1 0 0 CONOCOPHILLIPS COM 20825C104 34337 506664 SH DFND 0 0 0 CONSOLIDATED EDISON INC COM 209115104 1818 25039 SH DFND 1 0 0 CONSOLIDATED EDISON INC COM 209115104 11282 155432 SH DFND 0 0 0 CONSTELLATION BRANDS INC CL A 21036P108 2304 10934 SH DFND 1 0 0 CONSTELLATION BRANDS INC CL A 21036P108 17533 83219 SH DFND 0 0 0 CONTINENTAL RES INC COM 212015101 240 5191 SH DFND 0 0 0 COOPER COS INC COM NEW 216648402 9366 22661 SH DFND 1 0 0 COOPER COS INC COM NEW 216648402 67043 162209 SH DFND 0 0 0 COPART INC COM 217204106 2557 18433 SH DFND 1 0 0 COPART INC COM 217204106 11663 84077 SH DFND 0 0 0 CORE & MAIN INC CL A 21874C102 1327 50645 SH DFND 1 0 0 CORE & MAIN INC CL A 21874C102 106197 4051750 SH DFND 0 0 0 CORESITE RLTY CORP COM 21870Q105 1887 13619 SH DFND 1 0 0 CORESITE RLTY CORP COM 21870Q105 407 2937 SH DFND 0 0 0 CORNERSTONE ONDEMAND INC COM 21925Y103 206 3600 SH DFND 0 0 0 CORNING INC COM 219350105 2277 62389 SH DFND 1 0 0 CORNING INC COM 219350105 10058 275645 SH DFND 0 0 0 CORPORATE OFFICE PPTYS TR SH BEN INT 22002T108 945 34994 SH DFND 1 0 0 CORPORATE OFFICE PPTYS TR SH BEN INT 22002T108 175 6500 SH DFND 0 0 0 CORTEVA INC COM 22052L104 2172 51625 SH DFND 1 0 0 CORTEVA INC COM 22052L104 12964 308074 SH DFND 0 0 0 COSTAR GROUP INC COM 22160N109 2220 25800 SH DFND 1 0 0 COSTAR GROUP INC COM 22160N109 67382 782965 SH DFND 0 0 0 COSTCO WHSL CORP NEW COM 22160K105 49538 110243 SH DFND 1 0 0 COSTCO WHSL CORP NEW COM 22160K105 80104 178267 SH DFND 0 0 0 COTY INC COM CL A 222070203 165 21000 SH DFND 0 0 0 COUPA SOFTWARE INC COM 22266L106 986 4500 SH DFND 1 0 0 COUPA SOFTWARE INC COM 22266L106 4419 20162 SH DFND 0 0 0 COUPANG INC CL A 22266T109 19435 697834 SH DFND 0 0 0 COUSINS PPTYS INC COM NEW 222795502 1719 46105 SH DFND 1 0 0 COUSINS PPTYS INC COM NEW 222795502 390 10449 SH DFND 0 0 0 CRANE CO COM 224399105 275 2900 SH DFND 0 0 0 CREDICORP LTD COM G2519Y108 9206 82984 SH DFND 0 0 0 CREDIT ACCEP CORP MICH COM 225310101 339 580 SH DFND 0 0 0 CRESCENT PT ENERGY CORP COM 22576C101 172 37300 SH DFND 0 0 0 CRISPR THERAPEUTICS AG NAMEN AKT H17182108 437 3900 SH DFND 0 0 0 CROCS INC COM 227046109 625 4359 SH DFND 0 0 0 CRONOS GROUP INC COM 22717L101 69 12300 SH DFND 0 0 0 CROWDSTRIKE HLDGS INC CL A 22788C105 3116 12676 SH DFND 1 0 0 CROWDSTRIKE HLDGS INC CL A 22788C105 223716 910230 SH DFND 0 0 0 CROWN CASTLE INTL CORP NEW COM 22822V101 4903 28288 SH DFND 1 0 0 CROWN CASTLE INTL CORP NEW COM 22822V101 297112 1714241 SH DFND 0 0 0 CROWN HLDGS INC COM 228368106 824 8180 SH DFND 1 0 0 CROWN HLDGS INC COM 228368106 6515 64643 SH DFND 0 0 0 CSX CORP COM 126408103 4632 155750 SH DFND 1 0 0 CSX CORP COM 126408103 26999 907829 SH DFND 0 0 0 CUBESMART COM 229663109 3049 62937 SH DFND 1 0 0 CUBESMART COM 229663109 681 14049 SH DFND 0 0 0 CULLEN FROST BANKERS INC COM 229899109 470 3962 SH DFND 0 0 0 CUMMINS INC COM 231021106 2413 10746 SH DFND 1 0 0 CUMMINS INC COM 231021106 17988 80102 SH DFND 0 0 0 CURTISS WRIGHT CORP COM 231561101 353 2800 SH DFND 0 0 0 CVS HEALTH CORP COM 126650100 7270 85665 SH DFND 1 0 0 CVS HEALTH CORP COM 126650100 38465 453277 SH DFND 0 0 0 CYBERARK SOFTWARE LTD SHS M2682V108 423 2681 SH DFND 1 0 0 CYBERARK SOFTWARE LTD SHS M2682V108 184282 1167673 SH DFND 0 0 0 CYRUSONE INC COM 23283R100 3023 39054 SH DFND 1 0 0 CYRUSONE INC COM 23283R100 58908 760984 SH DFND 0 0 0 CYTOKINETICS INC COM NEW 23282W605 52834 1478777 SH DFND 0 0 0 CYTOKINETICS INC COM NEW 23282W605 30215 912015 SH DFND 1 0 0 D R HORTON INC COM 23331A109 4964 59110 SH DFND 1 0 0 D R HORTON INC COM 23331A109 62765 747470 SH DFND 0 0 0 DADA NEXUS LTD ADS 23344D108 1224 61100 SH DFND 0 0 0 DANAHER CORPORATION COM 235851102 47046 154534 SH DFND 1 0 0 DANAHER CORPORATION COM 235851102 1043914 3428964 SH DFND 0 0 0 DAQO NEW ENERGY CORP SPNSRD ADS NEW 23703Q203 7344 128839 SH DFND 1 0 0 DAQO NEW ENERGY CORP SPNSRD ADS NEW 23703Q203 31605 554477 SH DFND 0 0 0 DARDEN RESTAURANTS INC COM 237194105 1305 8615 SH DFND 1 0 0 DARDEN RESTAURANTS INC COM 237194105 10636 70222 SH DFND 0 0 0 DARLING INGREDIENTS INC COM 237266101 116413 1619096 SH DFND 0 0 0 DATADOG INC CL A COM 23804L103 1737 12292 SH DFND 1 0 0 DATADOG INC CL A COM 23804L103 7412 52433 SH DFND 0 0 0 DAVITA INC COM 23918K108 582 5009 SH DFND 1 0 0 DAVITA INC COM 23918K108 3036 26112 SH DFND 0 0 0 DECIPHERA PHARMACEUTICALS IN COM 24344T101 7541 221919 SH DFND 1 0 0 DECIPHERA PHARMACEUTICALS IN COM 24344T101 17981 529179 SH DFND 0 0 0 DECKERS OUTDOOR CORP COM 243537107 714 1983 SH DFND 0 0 0 DEERE & CO COM 244199105 8376 24997 SH DFND 1 0 0 DEERE & CO COM 244199105 178791 533595 SH DFND 0 0 0 DELL TECHNOLOGIES INC CL C 24703L202 1766 16970 SH DFND 1 0 0 DELL TECHNOLOGIES INC CL C 24703L202 7678 73802 SH DFND 0 0 0 DELTA AIR LINES INC DEL COM NEW 247361702 459 10782 SH DFND 1 0 0 DELTA AIR LINES INC DEL COM NEW 247361702 6862 161024 SH DFND 0 0 0 DENALI THERAPEUTICS INC COM 24823R105 13166 260970 SH DFND 1 0 0 DENALI THERAPEUTICS INC COM 24823R105 30650 607533 SH DFND 0 0 0 DENBURY INC COM 24790A101 211 3007 SH DFND 0 0 0 DENISON MINES CORP COM 248356107 96 66081 SH DFND 0 0 0 DENTSPLY SIRONA INC COM 24906P109 1152 19852 SH DFND 1 0 0 DENTSPLY SIRONA INC COM 24906P109 4897 84354 SH DFND 0 0 0 DESCARTES SYS GROUP INC COM 249906108 611 7512 SH DFND 0 0 0 DESKTOP METAL INC COM CL A 25058X105 95 13197 SH DFND 0 0 0 DESPEGAR COM CORP ORD SHS G27358103 250 20811 SH DFND 0 0 0 DEUTSCHE BANK A G NAMEN AKT D18190898 2002 156522 SH DFND 1 0 0 DEUTSCHE BANK A G NAMEN AKT D18190898 12586 983836 SH DFND 0 0 0 DEVON ENERGY CORP NEW COM 25179M103 8570 241340 SH DFND 1 0 0 DEVON ENERGY CORP NEW COM 25179M103 7534 212162 SH DFND 0 0 0 DEXCOM INC COM 252131107 3490 6382 SH DFND 1 0 0 DEXCOM INC COM 252131107 95061 173831 SH DFND 0 0 0 DIAMONDBACK ENERGY INC COM 25278X109 42 448 SH DFND 1 0 0 DIAMONDBACK ENERGY INC COM 25278X109 2464 26018 SH DFND 0 0 0 DIAMONDROCK HOSPITALITY CO COM 252784301 610 64590 SH DFND 1 0 0 DIAMONDROCK HOSPITALITY CO COM 252784301 144 15200 SH DFND 0 0 0 DICERNA PHARMACEUTICALS INC COM 253031108 5098 252880 SH DFND 1 0 0 DICERNA PHARMACEUTICALS INC COM 253031108 11171 554107 SH DFND 0 0 0 DICKS SPORTING GOODS INC COM 253393102 504 4208 SH DFND 0 0 0 DIDI GLOBAL INC SPONSORED ADS 23292E108 2375 304836 SH DFND 0 0 0 DIGITAL RLTY TR INC COM 253868103 15443 106910 SH DFND 1 0 0 DIGITAL RLTY TR INC COM 253868103 420737 2912680 SH DFND 0 0 0 DIGITAL TURBINE INC COM NEW 25400W102 406 5904 SH DFND 0 0 0 DIGITALBRIDGE GROUP INC CL A COM 25401T108 935 155078 SH DFND 1 0 0 DIGITALBRIDGE GROUP INC CL A COM 25401T108 186 30800 SH DFND 0 0 0 DIODES INC COM 254543101 264 2909 SH DFND 0 0 0 DISCOVER FINL SVCS COM 254709108 2464 20056 SH DFND 1 0 0 DISCOVER FINL SVCS COM 254709108 17195 139972 SH DFND 0 0 0 DISCOVERY INC COM SER C 25470F302 639 26307 SH DFND 1 0 0 DISCOVERY INC COM SER A 25470F104 274 10800 SH DFND 1 0 0 DISCOVERY INC COM SER C 25470F302 3049 125631 SH DFND 0 0 0 DISCOVERY INC COM SER A 25470F104 1669 65772 SH DFND 0 0 0 DISH NETWORK CORPORATION CL A 25470M109 766 17629 SH DFND 1 0 0 DISH NETWORK CORPORATION CL A 25470M109 3837 88277 SH DFND 0 0 0 DISH NETWORK CORPORATION NOTE 3.375% 8/1 25470MAB5 21730 500000 SH DFND 0 0 0 DISNEY WALT CO COM 254687106 36318 214681 SH DFND 1 0 0 DISNEY WALT CO COM 254687106 190496 1126067 SH DFND 0 0 0 DIVERSIFIED HEALTHCARE TR COM SH BEN INT 25525P107 247 72992 SH DFND 1 0 0 DIVERSIFIED HEALTHCARE TR COM SH BEN INT 25525P107 67 19700 SH DFND 0 0 0 DOCUSIGN INC COM 256163106 3224 12523 SH DFND 1 0 0 DOCUSIGN INC COM 256163106 13618 52901 SH DFND 0 0 0 DOLBY LABORATORIES INC COM CL A 25659T107 396 4500 SH DFND 0 0 0 DOLLAR GEN CORP NEW COM 256677105 3324 15669 SH DFND 1 0 0 DOLLAR GEN CORP NEW COM 256677105 28961 136518 SH DFND 0 0 0 DOLLAR TREE INC COM 256746108 1559 16283 SH DFND 1 0 0 DOLLAR TREE INC COM 256746108 8136 85004 SH DFND 0 0 0 DOMINION ENERGY INC COM 25746U109 4107 56251 SH DFND 1 0 0 DOMINION ENERGY INC COM 25746U109 388755 5323950 SH DFND 0 0 0 DOMINOS PIZZA INC COM 25754A201 1261 2643 SH DFND 1 0 0 DOMINOS PIZZA INC COM 25754A201 9724 20389 SH DFND 0 0 0 DOMTAR CORP COM NEW 257559203 656 12025 SH DFND 1 0 0 DOMTAR CORP COM NEW 257559203 33562 615373 SH DFND 0 0 0 DONALDSON INC COM 257651109 478 8333 SH DFND 0 0 0 DOORDASH INC CL A 25809K105 862 4186 SH DFND 1 0 0 DOORDASH INC CL A 25809K105 3943 19142 SH DFND 0 0 0 DORMAN PRODS INC COM 258278100 208 2200 SH DFND 0 0 0 DOUGLAS EMMETT INC COM 25960P109 1636 51751 SH DFND 1 0 0 DOUGLAS EMMETT INC COM 25960P109 412 13042 SH DFND 0 0 0 DOUYU INTL HLDGS LTD SPONSORED ADS 25985W105 78 23800 SH DFND 0 0 0 DOVER CORP COM 260003108 1666 10711 SH DFND 1 0 0 DOVER CORP COM 260003108 9787 62941 SH DFND 0 0 0 DOW INC COM 260557103 2844 49406 SH DFND 1 0 0 DOW INC COM 260557103 16527 287129 SH DFND 0 0 0 DRAFTKINGS INC COM CL A 26142R104 1654 34338 SH DFND 1 0 0 DRAFTKINGS INC COM CL A 26142R104 6443 133792 SH DFND 0 0 0 DROPBOX INC CL A 26210C104 9706 332168 SH DFND 1 0 0 DROPBOX INC CL A 26210C104 407790 13955843 SH DFND 0 0 0 DT MIDSTREAM INC COMMON STOCK 23345M107 325 7036 SH DFND 0 0 0 DTE ENERGY CO COM 233331107 1446 12947 SH DFND 1 0 0 DTE ENERGY CO COM 233331107 189690 1698051 SH DFND 0 0 0 DUKE ENERGY CORP NEW COM NEW 26441C204 5366 54987 SH DFND 1 0 0 DUKE ENERGY CORP NEW COM NEW 26441C204 79084 810371 SH DFND 0 0 0 DUKE REALTY CORP COM NEW 264411505 6857 143237 SH DFND 1 0 0 DUKE REALTY CORP COM NEW 264411505 19066 398300 SH DFND 0 0 0 DUPONT DE NEMOURS INC COM 26614N102 2502 36795 SH DFND 1 0 0 DUPONT DE NEMOURS INC COM 26614N102 14046 206599 SH DFND 0 0 0 DURECT CORP COM 266605104 17 13500 SH DFND 0 0 0 DXC TECHNOLOGY CO COM 23355L106 34 1007 SH DFND 1 0 0 DXC TECHNOLOGY CO COM 23355L106 1064 31657 SH DFND 0 0 0 DYNATRACE INC COM NEW 268150109 811 11427 SH DFND 1 0 0 DYNATRACE INC COM NEW 268150109 3439 48462 SH DFND 0 0 0 EAGLE MATLS INC COM 26969P108 124 948 SH DFND 1 0 0 EAGLE MATLS INC COM 26969P108 382 2912 SH DFND 0 0 0 EAST WEST BANCORP INC COM 27579R104 731 9423 SH DFND 0 0 0 EASTERLY GOVT PPTYS INC COM 27616P103 537 25988 SH DFND 1 0 0 EASTERLY GOVT PPTYS INC COM 27616P103 118 5700 SH DFND 0 0 0 EASTERN BANKSHARES INC COM 27627N105 240 11826 SH DFND 0 0 0 EASTGROUP PPTYS INC COM 277276101 2050 12301 SH DFND 1 0 0 EASTGROUP PPTYS INC COM 277276101 446 2678 SH DFND 0 0 0 EASTMAN CHEM CO COM 277432100 876 8698 SH DFND 1 0 0 EASTMAN CHEM CO COM 277432100 7355 73011 SH DFND 0 0 0 EATON CORP PLC SHS G29183103 6273 42012 SH DFND 1 0 0 EATON CORP PLC SHS G29183103 49309 330249 SH DFND 0 0 0 EBANG INTL HLDGS INC CL A SHS G3R33A106 28 14900 SH DFND 0 0 0 EBAY INC. COM 278642103 3637 52199 SH DFND 1 0 0 EBAY INC. COM 278642103 141297 2028097 SH DFND 0 0 0 ECOLAB INC COM 278865100 25160 120602 SH DFND 1 0 0 ECOLAB INC COM 278865100 732335 3510376 SH DFND 0 0 0 EDISON INTL COM 281020107 1425 25687 SH DFND 1 0 0 EDISON INTL COM 281020107 204156 3680478 SH DFND 0 0 0 EDITAS MEDICINE INC COM 28106W103 4088 99511 SH DFND 0 0 0 EDWARDS LIFESCIENCES CORP COM 28176E108 7649 67569 SH DFND 1 0 0 EDWARDS LIFESCIENCES CORP COM 28176E108 92916 820736 SH DFND 0 0 0 ELANCO ANIMAL HEALTH INC COM 28414H103 938 29417 SH DFND 1 0 0 ELANCO ANIMAL HEALTH INC COM 28414H103 61727 1935623 SH DFND 0 0 0 ELASTIC N V ORD SHS N14506104 619 4153 SH DFND 0 0 0 ELBIT SYS LTD ORD M3760D101 73 502 SH DFND 1 0 0 ELBIT SYS LTD ORD M3760D101 414 2863 SH DFND 0 0 0 ELDORADO GOLD CORP NEW COM 284902509 94 12200 SH DFND 0 0 0 ELECTRONIC ARTS INC COM 285512109 16394 115248 SH DFND 1 0 0 ELECTRONIC ARTS INC COM 285512109 75328 529546 SH DFND 0 0 0 ELEMENT SOLUTIONS INC COM 28618M106 301 13865 SH DFND 0 0 0 EMCOR GROUP INC COM 29084Q100 429 3721 SH DFND 0 0 0 EMERGENT BIOSOLUTIONS INC COM 29089Q105 2302 45980 SH DFND 1 0 0 EMERGENT BIOSOLUTIONS INC COM 29089Q105 170 3400 SH DFND 0 0 0 EMERSON ELEC CO COM 291011104 3805 40389 SH DFND 1 0 0 EMERSON ELEC CO COM 291011104 20911 221991 SH DFND 0 0 0 EMPIRE ST RLTY TR INC CL A 292104106 445 44350 SH DFND 1 0 0 EMPIRE ST RLTY TR INC CL A 292104106 94 9400 SH DFND 0 0 0 ENBRIDGE INC COM 29250N105 5040 126538 SH DFND 1 0 0 ENBRIDGE INC COM 29250N105 27634 693761 SH DFND 0 0 0 ENCOMPASS HEALTH CORP COM 29261A100 52 695 SH DFND 1 0 0 ENCOMPASS HEALTH CORP COM 29261A100 498 6635 SH DFND 0 0 0 ENDEAVOUR SILVER CORP COM 29258Y103 45 11100 SH DFND 0 0 0 ENDO INTL PLC SHS G30401106 1164 359319 SH DFND 0 0 0 ENEL AMERICAS S A SPONSORED ADR 29274F104 4 37922 SH DFND 0 0 0 ENEL CHILE S.A. SPONSORED ADR 29278D105 3 59119 SH DFND 0 0 0 ENERGY FUELS INC COM NEW 292671708 90 12915 SH DFND 0 0 0 ENERPLUS CORP COM 292766102 180 22500 SH DFND 0 0 0 ENERSYS COM 29275Y102 213 2861 SH DFND 0 0 0 ENLINK MIDSTREAM LLC COM UNIT REP LTD 29336T100 155 22800 SH DFND 0 0 0 ENPHASE ENERGY INC COM 29355A107 1230 8199 SH DFND 1 0 0 ENPHASE ENERGY INC COM 29355A107 116925 779661 SH DFND 0 0 0 ENSIGN GROUP INC COM 29358P101 270 3600 SH DFND 0 0 0 ENTEGRIS INC COM 29362U104 1146 9100 SH DFND 0 0 0 ENTERGY CORP NEW COM 29364G103 1300 13089 SH DFND 1 0 0 ENTERGY CORP NEW COM 29364G103 284487 2864641 SH DFND 0 0 0 ENVESTNET INC COM 29404K106 323 4030 SH DFND 0 0 0 ENVISTA HOLDINGS CORPORATION COM 29415F104 464 11100 SH DFND 0 0 0 EOG RES INC COM 26875P101 11589 144377 SH DFND 1 0 0 EOG RES INC COM 26875P101 16389 204175 SH DFND 0 0 0 EPAM SYS INC COM 29414B104 2003 3511 SH DFND 1 0 0 EPAM SYS INC COM 29414B104 9477 16613 SH DFND 0 0 0 EPR PPTYS COM SH BEN INT 26884U109 1127 22831 SH DFND 1 0 0 EPR PPTYS COM SH BEN INT 26884U109 250 5054 SH DFND 0 0 0 EQT CORP COM 26884L109 417 20391 SH DFND 0 0 0 EQUIFAX INC COM 294429105 2203 8692 SH DFND 1 0 0 EQUIFAX INC COM 294429105 269644 1064021 SH DFND 0 0 0 EQUINIX INC COM 29444U700 48984 61995 SH DFND 1 0 0 EQUINIX INC COM 29444U700 1050538 1329576 SH DFND 0 0 0 EQUINOX GOLD CORP COM 29446Y502 136 20684 SH DFND 0 0 0 EQUITABLE HLDGS INC COM 29452E101 679 22924 SH DFND 1 0 0 EQUITABLE HLDGS INC COM 29452E101 4564 153973 SH DFND 0 0 0 EQUITRANS MIDSTREAM CORP COM 294600101 309 30502 SH DFND 0 0 0 EQUITY COMWLTH COM SH BEN INT 294628102 943 36285 SH DFND 1 0 0 EQUITY COMWLTH COM SH BEN INT 294628102 219 8437 SH DFND 0 0 0 EQUITY LIFESTYLE PPTYS INC COM 29472R108 5047 64625 SH DFND 1 0 0 EQUITY LIFESTYLE PPTYS INC COM 29472R108 8831 113066 SH DFND 0 0 0 EQUITY RESIDENTIAL SH BEN INT 29476L107 11346 140205 SH DFND 1 0 0 EQUITY RESIDENTIAL SH BEN INT 29476L107 24797 306441 SH DFND 0 0 0 ERIE INDTY CO CL A 29530P102 321 1800 SH DFND 1 0 0 ERIE INDTY CO CL A 29530P102 1637 9174 SH DFND 0 0 0 ESPERION THERAPEUTICS INC NE COM 29664W105 1589 131849 SH DFND 0 0 0 ESSENT GROUP LTD COM G3198U102 37288 847259 SH DFND 0 0 0 ESSENTIAL PPTYS RLTY TR INC COM 29670E107 1004 35943 SH DFND 1 0 0 ESSENTIAL PPTYS RLTY TR INC COM 29670E107 223 8000 SH DFND 0 0 0 ESSENTIAL UTILS INC COM 29670G102 3038 65933 SH DFND 1 0 0 ESSENTIAL UTILS INC COM 29670G102 200419 4349357 SH DFND 0 0 0 ESSEX PPTY TR INC COM 297178105 7946 24850 SH DFND 1 0 0 ESSEX PPTY TR INC COM 297178105 7316 22881 SH DFND 0 0 0 ETSY INC COM 29786A106 1584 7616 SH DFND 1 0 0 ETSY INC COM 29786A106 99166 476852 SH DFND 0 0 0 EURONAV NV SHS B38564108 143 15076 SH DFND 0 0 0 EURONET WORLDWIDE INC COM 298736109 453 3563 SH DFND 0 0 0 EVERBRIDGE INC COM 29978A104 213 1411 SH DFND 1 0 0 EVERBRIDGE INC COM 29978A104 71997 476675 SH DFND 0 0 0 EVERCORE INC CLASS A 29977A105 398 2976 SH DFND 0 0 0 EVEREST RE GROUP LTD COM G3223R108 728 2902 SH DFND 1 0 0 EVEREST RE GROUP LTD COM G3223R108 4371 17429 SH DFND 0 0 0 EVERGY INC COM 30034W106 952 15304 SH DFND 1 0 0 EVERGY INC COM 30034W106 260024 4180458 SH DFND 0 0 0 EVERSOURCE ENERGY COM 30040W108 1957 23931 SH DFND 1 0 0 EVERSOURCE ENERGY COM 30040W108 151641 1854714 SH DFND 0 0 0 EVGO INC CL A COM 30052F100 21991 2698269 SH DFND 0 0 0 EVOQUA WATER TECHNOLOGIES CO COM 30057T105 308 8208 SH DFND 0 0 0 EXACT SCIENCES CORP COM 30063P105 1021 10700 SH DFND 1 0 0 EXACT SCIENCES CORP COM 30063P105 4483 46961 SH DFND 0 0 0 EXCHANGE TRADED CONCEPTS TR ROBO GLB ETF 301505707 660 10246 SH DFND 1 0 0 EXCHANGE TRADED CONCEPTS TR ROBO GLB ETF 301505707 2978 46231 SH DFND 0 0 0 EXELIXIS INC COM 30161Q104 14660 693482 SH DFND 1 0 0 EXELIXIS INC COM 30161Q104 39036 1846516 SH DFND 0 0 0 EXELON CORP COM 30161N101 3103 64201 SH DFND 1 0 0 EXELON CORP COM 30161N101 244709 5062231 SH DFND 0 0 0 EXLSERVICE HOLDINGS INC COM 302081104 283 2300 SH DFND 0 0 0 EXPEDIA GROUP INC COM NEW 30212P303 1473 8985 SH DFND 1 0 0 EXPEDIA GROUP INC COM NEW 30212P303 167794 1023761 SH DFND 0 0 0 EXPEDITORS INTL WASH INC COM 302130109 4408 37002 SH DFND 1 0 0 EXPEDITORS INTL WASH INC COM 302130109 20096 168688 SH DFND 0 0 0 EXPONENT INC COM 30214U102 391 3456 SH DFND 0 0 0 EXTRA SPACE STORAGE INC COM 30225T102 11482 68352 SH DFND 1 0 0 EXTRA SPACE STORAGE INC COM 30225T102 136503 812561 SH DFND 0 0 0 EXXON MOBIL CORP COM 30231G102 30459 517838 SH DFND 1 0 0 EXXON MOBIL CORP COM 30231G102 85962 1461440 SH DFND 0 0 0 F N B CORP COM 302520101 226 19430 SH DFND 0 0 0 F5 NETWORKS INC COM 315616102 1361 6847 SH DFND 1 0 0 F5 NETWORKS INC COM 315616102 4480 22538 SH DFND 0 0 0 FABRINET SHS G3323L100 297 2900 SH DFND 0 0 0 FACEBOOK INC CL A 30303M102 132730 391083 SH DFND 1 0 0 FACEBOOK INC CL A 30303M102 574070 1691477 SH DFND 0 0 0 FACTSET RESH SYS INC COM 303075105 996 2523 SH DFND 1 0 0 FACTSET RESH SYS INC COM 303075105 5573 14116 SH DFND 0 0 0 FAIR ISAAC CORP COM 303250104 716 1800 SH DFND 1 0 0 FAIR ISAAC CORP COM 303250104 3120 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7400 SH DFND 0 0 0 INDUSTRIAL LOGISTICS PPTYS T COM SHS BEN INT 456237106 511 20136 SH DFND 1 0 0 INDUSTRIAL LOGISTICS PPTYS T COM SHS BEN INT 456237106 140 5500 SH DFND 0 0 0 INGERSOLL RAND INC COM 45687V106 1404 27858 SH DFND 1 0 0 INGERSOLL RAND INC COM 45687V106 7771 154145 SH DFND 0 0 0 INGEVITY CORP COM 45688C107 1259 17646 SH DFND 1 0 0 INGEVITY CORP COM 45688C107 31956 447750 SH DFND 0 0 0 INGREDION INC COM 457187102 408 4579 SH DFND 0 0 0 INMODE LTD SHS M5425M103 301 1889 SH DFND 0 0 0 INNOVATIVE INDL PPTYS INC COM 45781V101 1689 7306 SH DFND 1 0 0 INNOVATIVE INDL PPTYS INC COM 45781V101 370 1600 SH DFND 0 0 0 INOVALON HLDGS INC COM CL A 45781D101 230 5700 SH DFND 0 0 0 INOVIO PHARMACEUTICALS INC COM NEW 45773H201 112 15700 SH DFND 0 0 0 INSIGHT ENTERPRISES INC COM 45765U103 248 2749 SH DFND 0 0 0 INSMED INC COM PAR $.01 457669307 25252 916933 SH DFND 1 0 0 INSMED INC COM PAR $.01 457669307 54867 1992267 SH DFND 0 0 0 INSPERITY INC COM 45778Q107 241 2173 SH DFND 0 0 0 INSPIRE MED SYS INC COM 457730109 433 1859 SH DFND 0 0 0 INSULET CORP COM 45784P101 1293 4551 SH DFND 1 0 0 INSULET CORP COM 45784P101 6598 23213 SH DFND 0 0 0 INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 322 4700 SH DFND 0 0 0 INTEL CORP COM 458140100 27760 521018 SH DFND 1 0 0 INTEL CORP COM 458140100 326875 6135052 SH DFND 0 0 0 INTELLIA THERAPEUTICS INC COM 45826J105 9011 67171 SH DFND 1 0 0 INTELLIA THERAPEUTICS INC COM 45826J105 25227 188053 SH DFND 0 0 0 INTERACTIVE BROKERS GROUP IN COM CL A 45841N107 337 5400 SH DFND 0 0 0 INTERCEPT PHARMACEUTICALS IN COM 45845P108 1579 106323 SH DFND 0 0 0 INTERCONTINENTAL EXCHANGE IN COM 45866F104 4937 43001 SH DFND 1 0 0 INTERCONTINENTAL EXCHANGE IN COM 45866F104 48390 421442 SH DFND 0 0 0 INTERCORP FINL SVCS INC SHS P5626F128 459 20567 SH DFND 0 0 0 INTERNATIONAL BUSINESS MACHS COM 459200101 17386 125145 SH DFND 1 0 0 INTERNATIONAL BUSINESS MACHS COM 459200101 50956 366775 SH DFND 0 0 0 INTERNATIONAL FLAVORS&FRAGRA COM 459506101 12597 94206 SH DFND 1 0 0 INTERNATIONAL FLAVORS&FRAGRA COM 459506101 160336 1199042 SH DFND 0 0 0 INTERNATIONAL PAPER CO COM 460146103 8482 151681 SH DFND 1 0 0 INTERNATIONAL PAPER CO COM 460146103 198719 3553638 SH DFND 0 0 0 INTERPUBLIC GROUP COS INC COM 460690100 1058 28843 SH DFND 1 0 0 INTERPUBLIC GROUP COS INC COM 460690100 10469 285506 SH DFND 0 0 0 INTUIT COM 461202103 19707 36527 SH DFND 1 0 0 INTUIT COM 461202103 197274 365655 SH DFND 0 0 0 INTUITIVE SURGICAL INC COM NEW 46120E602 7596 7641 SH DFND 1 0 0 INTUITIVE SURGICAL INC COM NEW 46120E602 352816 354892 SH DFND 0 0 0 INVESCO EXCHANGE TRADED FD T INVESCO MSCI 46137V407 1837 29005 SH DFND 0 0 0 INVESCO LTD SHS G491BT108 650 26970 SH DFND 1 0 0 INVESCO LTD SHS G491BT108 3870 160491 SH DFND 0 0 0 INVESCO MORTGAGE CAPITAL INC COM 46131B100 41 13035 SH DFND 0 0 0 INVESCO QQQ TR UNIT SER 1 46090E103 1836 5130 SH DFND 0 0 0 INVESTORS BANCORP INC NEW COM 46146L101 258 17100 SH DFND 0 0 0 INVITAE CORP COM 46185L103 319 11217 SH DFND 0 0 0 INVITATION HOMES INC COM 46187W107 8266 215657 SH DFND 1 0 0 INVITATION HOMES INC COM 46187W107 6114 159496 SH DFND 0 0 0 IONIS PHARMACEUTICALS INC COM 462222100 4551 135696 SH DFND 0 0 0 IOVANCE BIOTHERAPEUTICS INC COM 462260100 7702 312317 SH DFND 1 0 0 IOVANCE BIOTHERAPEUTICS INC COM 462260100 16911 685758 SH DFND 0 0 0 IPG PHOTONICS CORP COM 44980X109 364 2300 SH DFND 1 0 0 IPG PHOTONICS CORP COM 44980X109 336605 2125027 SH DFND 0 0 0 IQIYI INC SPONSORED ADS 46267X108 2844 354200 SH DFND 0 0 0 IQVIA HLDGS INC COM 46266C105 2997 12510 SH DFND 1 0 0 IQVIA HLDGS INC COM 46266C105 16580 69218 SH DFND 0 0 0 IRIDIUM COMMUNICATIONS INC COM 46269C102 296 7429 SH DFND 0 0 0 IROBOT CORP COM 462726100 132874 1692664 SH DFND 0 0 0 IRON MTN INC NEW COM 46284V101 827 19036 SH DFND 1 0 0 IRON MTN INC NEW COM 46284V101 9596 220860 SH DFND 0 0 0 IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 13500 1033687 SH DFND 0 0 0 ISHARES GOLD TR ISHARES NEW 464285204 4677 140000 SH DFND 1 0 0 ISHARES GOLD TR ISHARES NEW 464285204 866 25920 SH DFND 0 0 0 ISHARES INC MSCI GBL MIN VOL 464286525 3514 34200 SH DFND 1 0 0 ISHARES INC MSCI GBL MIN VOL 464286525 1520 14800 SH DFND 0 0 0 ISHARES INC MSCI EURZONE ETF 464286608 3493 72595 SH DFND 0 0 0 ISHARES INC MSCI PAC JP ETF 464286665 209 4285 SH DFND 0 0 0 ISHARES INC MSCI CDA ETF 464286509 568 15658 SH DFND 0 0 0 ISHARES TR IBOXX INV CP ETF 464287242 16633 125030 SH DFND 1 0 0 ISHARES TR ISHARES SEMICDTR 464287523 673 1510 SH DFND 1 0 0 ISHARES TR 3 7 YR TREAS BD 464288661 11715 90000 SH DFND 1 0 0 ISHARES TR JPMORGAN USD EMG 464288281 13812 125500 SH DFND 1 0 0 ISHARES TR CORE US AGGBD ET 464287226 21626 188330 SH DFND 1 0 0 ISHARES TR GLOBAL FINLS ETF 464287333 4527 57700 SH DFND 1 0 0 ISHARES TR 20 YR TR BD ETF 464287432 3215 22280 SH DFND 1 0 0 ISHARES TR MSCI INDIA ETF 46429B598 1310 26900 SH DFND 1 0 0 ISHARES TR USD INV GRDE ETF 464288620 4356 72471 SH DFND 1 0 0 ISHARES TR ISHS 5-10YR INVT 464288638 147 2450 SH DFND 1 0 0 ISHARES TR US INFRASTRUC 46435U713 3209 94146 SH DFND 1 0 0 ISHARES TR ESG AWR US AGRGT 46435U549 703 12750 SH DFND 1 0 0 ISHARES TR GLB CNS DISC ETF 464288745 6632 40200 SH DFND 1 0 0 ISHARES TR GLOBAL TECH ETF 464287291 8012 141400 SH DFND 1 0 0 ISHARES TR US HOME CONS ETF 464288752 14560 220000 SH Put DFND 1 0 0 ISHARES TR IBOXX INV CP ETF 464287242 19554 146995 SH DFND 0 0 0 ISHARES TR ISHARES SEMICDTR 464287523 10634 23849 SH DFND 0 0 0 ISHARES TR 3 7 YR TREAS BD 464288661 8511 65385 SH DFND 0 0 0 ISHARES TR JPMORGAN USD EMG 464288281 2629 23885 SH DFND 0 0 0 ISHARES TR CORE US AGGBD ET 464287226 29826 259743 SH DFND 0 0 0 ISHARES TR GLOBAL FINLS ETF 464287333 13815 176100 SH DFND 0 0 0 ISHARES TR 20 YR TR BD ETF 464287432 7314 50677 SH DFND 0 0 0 ISHARES TR MSCI INDIA ETF 46429B598 872 17905 SH DFND 0 0 0 ISHARES TR USD INV GRDE ETF 464288620 3633 60450 SH DFND 0 0 0 ISHARES TR ISHS 5-10YR INVT 464288638 1129 18800 SH DFND 0 0 0 ISHARES TR US INFRASTRUC 46435U713 6614 194010 SH DFND 0 0 0 ISHARES TR ESG AWR US AGRGT 46435U549 39363 714000 SH DFND 0 0 0 ISHARES TR HDG MSCI JAPAN 46434V886 3726 92765 SH DFND 0 0 0 ISHARES TR INTL DEV RE ETF 464288489 4113 146900 SH DFND 0 0 0 ISHARES TR A RATE CP BD ETF 46429B291 986 17500 SH DFND 0 0 0 ISHARES TR RUS 1000 VAL ETF 464287598 2402 15345 SH DFND 0 0 0 ISHARES TR MSCI USA QLT FCT 46432F339 4364 33135 SH DFND 0 0 0 ISHARES TR CUR HD EURZN ETF 46434V639 3735 103585 SH DFND 0 0 0 ISHARES TR GLOBAL ENERG ETF 464287341 1086 40448 SH DFND 0 0 0 ISHARES TR GL CLEAN ENE ETF 464288224 1866 86200 SH DFND 0 0 0 ISHARES TR TIPS BD ETF 464287176 4307 33730 SH DFND 0 0 0 ITRON INC COM 465741106 204 2700 SH DFND 0 0 0 ITT INC COM 45073V108 486 5666 SH DFND 0 0 0 ITURAN LOCATION AND CONTROL SHS M6158M104 254 10000 SH DFND 0 0 0 J2 GLOBAL INC COM 48123V102 393 2879 SH DFND 0 0 0 JABIL INC COM 466313103 590 10100 SH DFND 0 0 0 JACOBS ENGR GROUP INC COM 469814107 1105 8341 SH DFND 1 0 0 JACOBS ENGR GROUP INC COM 469814107 5779 43599 SH DFND 0 0 0 JANUS HENDERSON GROUP PLC ORD SHS G4474Y214 422 10200 SH DFND 0 0 0 JAZZ PHARMACEUTICALS PLC SHS USD G50871105 576 4426 SH DFND 1 0 0 JAZZ PHARMACEUTICALS PLC SHS USD G50871105 17071 131102 SH DFND 0 0 0 JBG SMITH PPTYS COM 46590V100 1132 38229 SH DFND 1 0 0 JBG SMITH PPTYS COM 46590V100 243 8200 SH DFND 0 0 0 JD.COM INC SPON ADR CL A 47215P106 58 1600 SH DFND 1 0 0 JD.COM INC SPON ADR CL A 47215P106 51520 1416192 SH DFND 0 0 0 JEFFERIES FINL GROUP INC COM 47233W109 551 14831 SH DFND 0 0 0 JETBLUE AWYS CORP COM 477143101 2800 183134 SH DFND 0 0 0 JINKOSOLAR HLDG CO LTD SPONSORED ADR 47759T100 2570 56100 SH DFND 0 0 0 JOHN BEAN TECHNOLOGIES CORP COM 477839104 325 2311 SH DFND 0 0 0 JOHNSON & JOHNSON COM 478160104 30577 189332 SH DFND 1 0 0 JOHNSON & JOHNSON COM 478160104 167587 1037689 SH DFND 0 0 0 JOHNSON CTLS INTL PLC SHS G51502105 14060 206516 SH DFND 1 0 0 JOHNSON CTLS INTL PLC SHS G51502105 1011403 14856100 SH DFND 0 0 0 JONES LANG LASALLE INC COM 48020Q107 866 3490 SH DFND 0 0 0 JOYY INC ADS REPSTG COM A 46591M109 5979 109045 SH DFND 0 0 0 JPMORGAN CHASE & CO COM 46625H100 73355 448134 SH DFND 1 0 0 JPMORGAN CHASE & CO COM 46625H100 233221 1424773 SH DFND 0 0 0 JUNIPER NETWORKS INC COM 48203R104 1660 60313 SH DFND 1 0 0 JUNIPER NETWORKS INC COM 48203R104 10537 382895 SH DFND 0 0 0 JUST EAT TAKEAWAY COM N V SPONSORED ADS 48214T305 25148 344223 SH DFND 0 0 0 KADANT INC COM 48282T104 508 2488 SH DFND 1 0 0 KADANT INC COM 48282T104 14433 70716 SH DFND 0 0 0 KADMON HLDGS INC COM 48283N106 124 14200 SH DFND 0 0 0 KALA PHARMACEUTICALS INC COM 483119103 1027 392107 SH DFND 0 0 0 KANSAS CITY SOUTHERN COM NEW 485170302 1842 6807 SH DFND 1 0 0 KANSAS CITY SOUTHERN COM NEW 485170302 10282 37989 SH DFND 0 0 0 KAR AUCTION SVCS INC COM 48238T109 169 10300 SH DFND 0 0 0 KARUNA THERAPEUTICS INC COM 48576A100 11860 96951 SH DFND 1 0 0 KARUNA THERAPEUTICS INC COM 48576A100 30389 248420 SH DFND 0 0 0 KB HOME COM 48666K109 239 6137 SH DFND 0 0 0 KBR INC COM 48242W106 376 9539 SH DFND 0 0 0 KE HLDGS INC SPONSORED ADS 482497104 7553 413652 SH DFND 0 0 0 KELLOGG CO COM 487836108 1117 17473 SH DFND 1 0 0 KELLOGG CO COM 487836108 6757 105711 SH DFND 0 0 0 KEMPER CORP COM 488401100 267 4000 SH DFND 0 0 0 KENNEDY-WILSON HOLDINGS INC COM 489398107 767 36689 SH DFND 1 0 0 KENNEDY-WILSON HOLDINGS INC COM 489398107 199 9500 SH DFND 0 0 0 KEURIG DR PEPPER INC COM 49271V100 1529 44757 SH DFND 1 0 0 KEURIG DR PEPPER INC COM 49271V100 13606 398304 SH DFND 0 0 0 KEYCORP COM 493267108 1437 66484 SH DFND 1 0 0 KEYCORP COM 493267108 9556 441974 SH DFND 0 0 0 KEYSIGHT TECHNOLOGIES INC COM 49338L103 2138 13013 SH DFND 1 0 0 KEYSIGHT TECHNOLOGIES INC COM 49338L103 11874 72275 SH DFND 0 0 0 KILROY RLTY CORP COM 49427F108 2393 36143 SH DFND 1 0 0 KILROY RLTY CORP COM 49427F108 477 7200 SH DFND 0 0 0 KIMBERLY-CLARK CORP COM 494368103 4896 36966 SH DFND 1 0 0 KIMBERLY-CLARK CORP COM 494368103 71983 543515 SH DFND 0 0 0 KIMCO RLTY CORP COM 49446R109 3808 183509 SH DFND 1 0 0 KIMCO RLTY CORP COM 49446R109 1694 81662 SH DFND 0 0 0 KINDER MORGAN INC DEL COM 49456B101 14249 851675 SH DFND 1 0 0 KINDER MORGAN INC DEL COM 49456B101 12228 730905 SH DFND 0 0 0 KINGSOFT CLOUD HLDGS LTD ADS 49639K101 1892 66800 SH DFND 0 0 0 KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 11550 1014036 SH DFND 1 0 0 KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 26435 2320869 SH DFND 0 0 0 KINROSS GOLD CORP COM 496902404 406 75804 SH DFND 1 0 0 KINROSS GOLD CORP COM 496902404 2246 419036 SH DFND 0 0 0 KINSALE CAP GROUP INC COM 49714P108 234 1448 SH DFND 0 0 0 KIRKLAND LAKE GOLD LTD COM 49741E100 2263 54336 SH DFND 1 0 0 KIRKLAND LAKE GOLD LTD COM 49741E100 3174 76225 SH DFND 0 0 0 KITE RLTY GROUP TR COM NEW 49803T300 526 25836 SH DFND 1 0 0 KITE RLTY GROUP TR COM NEW 49803T300 104 5123 SH DFND 0 0 0 KKR & CO INC COM 48251W104 2163 35527 SH DFND 1 0 0 KKR & CO INC COM 48251W104 20443 335800 SH DFND 0 0 0 KLA CORP COM NEW 482480100 30510 91209 SH DFND 1 0 0 KLA CORP COM NEW 482480100 701351 2096650 SH DFND 0 0 0 KNIGHT-SWIFT TRANSN HLDGS IN CL A 499049104 600 11723 SH DFND 1 0 0 KNIGHT-SWIFT TRANSN HLDGS IN CL A 499049104 1975 38627 SH DFND 0 0 0 KODIAK SCIENCES INC COM 50015M109 203 2116 SH DFND 0 0 0 KOHLS CORP COM 500255104 484 10273 SH DFND 0 0 0 KORN FERRY COM NEW 500643200 266 3681 SH DFND 0 0 0 KORNIT DIGITAL LTD SHS M6372Q113 1106 7643 SH DFND 0 0 0 KOSMOS ENERGY LTD COM 500688106 126 42600 SH DFND 0 0 0 KRAFT HEINZ CO COM 500754106 1688 45852 SH DFND 1 0 0 KRAFT HEINZ CO COM 500754106 8701 236302 SH DFND 0 0 0 KROGER CO COM 501044101 2249 55638 SH DFND 1 0 0 KROGER CO COM 501044101 11782 291413 SH DFND 0 0 0 KRONOS BIO INC COM 50107A104 1543 73616 SH DFND 1 0 0 KRONOS BIO INC COM 50107A104 2295 109483 SH DFND 0 0 0 KRYSTAL BIOTECH INC COM 501147102 10350 198237 SH DFND 1 0 0 KRYSTAL BIOTECH INC COM 501147102 22933 439255 SH DFND 0 0 0 KULICKE & SOFFA INDS INC COM 501242101 204 3505 SH DFND 0 0 0 L3HARRIS TECHNOLOGIES INC COM 502431109 3063 13909 SH DFND 1 0 0 L3HARRIS TECHNOLOGIES INC COM 502431109 15804 71755 SH DFND 0 0 0 LABORATORY CORP AMER HLDGS COM NEW 50540R409 4366 15514 SH DFND 1 0 0 LABORATORY CORP AMER HLDGS COM NEW 50540R409 25917 92085 SH DFND 0 0 0 LAM RESEARCH CORP COM 512807108 12578 22100 SH DFND 1 0 0 LAM RESEARCH CORP COM 512807108 581928 1022451 SH DFND 0 0 0 LAMAR ADVERTISING CO NEW CL A 512816109 654 5766 SH DFND 0 0 0 LAMB WESTON HLDGS INC COM 513272104 620 10095 SH DFND 1 0 0 LAMB WESTON HLDGS INC COM 513272104 3609 58814 SH DFND 0 0 0 LANDSTAR SYS INC COM 515098101 379 2400 SH DFND 0 0 0 LAS VEGAS SANDS CORP COM 517834107 889 24280 SH DFND 1 0 0 LAS VEGAS SANDS CORP COM 517834107 6807 185982 SH DFND 0 0 0 LATTICE SEMICONDUCTOR CORP COM 518415104 622 9617 SH DFND 0 0 0 LAUDER ESTEE COS INC CL A 518439104 22558 75290 SH DFND 1 0 0 LAUDER ESTEE COS INC CL A 518439104 192414 641530 SH DFND 0 0 0 LCI INDS COM 50189K103 202 1500 SH DFND 0 0 0 LEAR CORP COM NEW 521865204 634 4050 SH DFND 1 0 0 LEAR CORP COM NEW 521865204 2720 17381 SH DFND 0 0 0 LEGGETT & PLATT INC COM 524660107 748 16679 SH DFND 0 0 0 LEIDOS HOLDINGS INC COM 525327102 844 8782 SH DFND 1 0 0 LEIDOS HOLDINGS INC COM 525327102 4375 45511 SH DFND 0 0 0 LENNAR CORP CL A 526057104 10821 115506 SH DFND 1 0 0 LENNAR CORP CL A 526057104 54292 579555 SH DFND 0 0 0 LENNOX INTL INC COM 526107107 1049 3565 SH DFND 1 0 0 LENNOX INTL INC COM 526107107 3884 13204 SH DFND 0 0 0 LESLIES INC COM 527064109 1121 54559 SH DFND 1 0 0 LESLIES INC COM 527064109 101755 4954027 SH DFND 0 0 0 LEXINFINTECH HLDGS LTD ADR 528877103 292 49600 SH DFND 0 0 0 LEXINGTON REALTY TRUST COM 529043101 1087 85264 SH DFND 1 0 0 LEXINGTON REALTY TRUST COM 529043101 279 21886 SH DFND 0 0 0 LHC GROUP INC COM 50187A107 26105 166371 SH DFND 0 0 0 LI AUTO INC SPONSORED ADS 50202M102 7869 605328 SH DFND 0 0 0 LIBERTY BROADBAND CORP COM SER A 530307107 286 1700 SH DFND 1 0 0 LIBERTY BROADBAND CORP COM SER C 530307305 1717 9944 SH DFND 1 0 0 LIBERTY BROADBAND CORP COM SER A 530307107 1102 6545 SH DFND 0 0 0 LIBERTY BROADBAND CORP COM SER C 530307305 7390 42787 SH DFND 0 0 0 LIBERTY GLOBAL PLC SHS CL C G5480U120 1099 37297 SH DFND 1 0 0 LIBERTY GLOBAL PLC SHS CL A G5480U104 455 15283 SH DFND 1 0 0 LIBERTY GLOBAL PLC SHS CL C G5480U120 2983 101262 SH DFND 0 0 0 LIBERTY GLOBAL PLC SHS CL A G5480U104 1371 45998 SH DFND 0 0 0 LIBERTY LATIN AMERICA LTD COM CL C G9001E128 141 10760 SH DFND 0 0 0 LIBERTY MEDIA CORP DEL COM SER C FRMLA 531229854 709 13787 SH DFND 1 0 0 LIBERTY MEDIA CORP DEL COM A SIRIUSXM 531229409 215 4550 SH DFND 1 0 0 LIBERTY MEDIA CORP DEL COM C SIRIUSXM 531229607 770 16228 SH DFND 1 0 0 LIBERTY MEDIA CORP DEL COM SER C FRMLA 531229854 2800 54464 SH DFND 0 0 0 LIBERTY MEDIA CORP DEL COM A SIRIUSXM 531229409 1115 23654 SH DFND 0 0 0 LIBERTY MEDIA CORP DEL COM C SIRIUSXM 531229607 2171 45727 SH DFND 0 0 0 LIFE STORAGE INC COM 53223X107 2787 24287 SH DFND 1 0 0 LIFE STORAGE INC COM 53223X107 602 5250 SH DFND 0 0 0 LIGHTSPEED COMMERCE INC SUB VTG SHS 53229C107 672 6963 SH DFND 1 0 0 LIGHTSPEED COMMERCE INC SUB VTG SHS 53229C107 2652 27493 SH DFND 0 0 0 LILLY ELI & CO COM 532457108 12240 52976 SH DFND 1 0 0 LILLY ELI & CO COM 532457108 164959 713954 SH DFND 0 0 0 LINCOLN ELEC HLDGS INC COM 533900106 513 3985 SH DFND 0 0 0 LINCOLN NATL CORP IND COM 534187109 842 12241 SH DFND 1 0 0 LINCOLN NATL CORP IND COM 534187109 5818 84628 SH DFND 0 0 0 LINDE PLC SHS G5494J103 109491 368903 SH DFND 1 0 0 LINDE PLC SHS G5494J103 32856 110700 SH Call DFND 1 0 0 LINDE PLC SHS G5494J103 103232 347817 SH DFND 0 0 0 LINDE PLC SHS G5494J103 58113 195800 SH Call DFND 0 0 0 LITHIA MTRS INC COM 536797103 654 2064 SH DFND 0 0 0 LITTELFUSE INC COM 537008104 437 1600 SH DFND 0 0 0 LIVANOVA PLC SHS G5509L101 268 3383 SH DFND 0 0 0 LIVE NATION ENTERTAINMENT IN COM 538034109 3419 37521 SH DFND 1 0 0 LIVE NATION ENTERTAINMENT IN COM 538034109 4861 53333 SH DFND 0 0 0 LIVENT CORP COM 53814L108 220 9500 SH DFND 0 0 0 LIVEPERSON INC COM 538146101 258 4376 SH DFND 0 0 0 LIVERAMP HLDGS INC COM 53815P108 218 4617 SH DFND 0 0 0 LKQ CORP COM 501889208 1051 20890 SH DFND 1 0 0 LKQ CORP COM 501889208 5876 116776 SH DFND 0 0 0 LOCKHEED MARTIN CORP COM 539830109 5385 15604 SH DFND 1 0 0 LOCKHEED MARTIN CORP COM 539830109 8793 25479 SH DFND 0 0 0 LOEWS CORP COM 540424108 912 16913 SH DFND 1 0 0 LOEWS CORP COM 540424108 5475 101523 SH DFND 0 0 0 LOGITECH INTL S A SHS H50430232 10890 122009 SH DFND 1 0 0 LOGITECH INTL S A SHS H50430232 180267 2019715 SH DFND 0 0 0 LOMA NEGRA C I A S A MTN 14 SPONSORED ADS 54150E104 31 11000 SH DFND 0 0 0 LOUISIANA PAC CORP COM 546347105 2092 34090 SH DFND 1 0 0 LOUISIANA PAC CORP COM 546347105 74926 1220886 SH DFND 0 0 0 LOWES COS INC COM 548661107 9861 48609 SH DFND 1 0 0 LOWES COS INC COM 548661107 191643 944709 SH DFND 0 0 0 LPL FINL HLDGS INC COM 50212V100 847 5400 SH DFND 0 0 0 LTC PPTYS INC COM 502175102 380 12001 SH DFND 1 0 0 LTC PPTYS INC COM 502175102 95 3000 SH DFND 0 0 0 LUFAX HOLDING LTD ADS REP SHS CL A 54975P102 1527 218791 SH DFND 0 0 0 LULULEMON ATHLETICA INC COM 550021109 3238 8000 SH DFND 1 0 0 LULULEMON ATHLETICA INC COM 550021109 175478 433602 SH DFND 0 0 0 LUMEN TECHNOLOGIES INC COM 550241103 954 77005 SH DFND 1 0 0 LUMEN TECHNOLOGIES INC COM 550241103 3945 318429 SH DFND 0 0 0 LUMENTUM HLDGS INC COM 55024U109 426 5100 SH DFND 0 0 0 LUMINAR TECHNOLOGIES INC COM CL A 550424105 181 11612 SH DFND 0 0 0 LYFT INC CL A COM 55087P104 4912 91669 SH DFND 1 0 0 LYFT INC CL A COM 55087P104 3664 68369 SH DFND 0 0 0 LYONDELLBASELL INDUSTRIES N SHS - A - N53745100 1674 17837 SH DFND 1 0 0 LYONDELLBASELL INDUSTRIES N SHS - A - N53745100 11169 119010 SH DFND 0 0 0 M & T BK CORP COM 55261F104 1205 8066 SH DFND 1 0 0 M & T BK CORP COM 55261F104 9245 61908 SH DFND 0 0 0 MACERICH CO COM 554382101 1132 67740 SH DFND 1 0 0 MACERICH CO COM 554382101 225 13468 SH DFND 0 0 0 MACK CALI RLTY CORP COM 554489104 466 27209 SH DFND 1 0 0 MACK CALI RLTY CORP COM 554489104 75 4401 SH DFND 0 0 0 MACOM TECH SOLUTIONS HLDGS I COM 55405Y100 234 3600 SH DFND 0 0 0 MACYS INC COM 55616P104 463 20472 SH DFND 0 0 0 MADDEN STEVEN LTD COM 556269108 241 6000 SH DFND 0 0 0 MADISON SQUARE GRDN SPRT COR CL A 55825T103 218 1170 SH DFND 0 0 0 MAGIC SOFTWARE ENTERPRISES L ORD 559166103 358 17924 SH DFND 0 0 0 MAGNA INTL INC COM 559222401 1452 19300 SH DFND 1 0 0 MAGNA INTL INC COM 559222401 7040 93563 SH DFND 0 0 0 MAGNITE INC COM 55955D100 232 8300 SH DFND 0 0 0 MAGNOLIA OIL & GAS CORP CL A 559663109 182 10215 SH DFND 0 0 0 MAKEMYTRIP LIMITED MAURITIUS SHS V5633W109 17179 631818 SH DFND 0 0 0 MANHATTAN ASSOCIATES INC COM 562750109 643 4200 SH DFND 0 0 0 MANNKIND CORP COM NEW 56400P706 71 16374 SH DFND 0 0 0 MANPOWERGROUP INC WIS COM 56418H100 422 3900 SH DFND 0 0 0 MANULIFE FINL CORP COM 56501R106 2346 121902 SH DFND 1 0 0 MANULIFE FINL CORP COM 56501R106 16871 876646 SH DFND 0 0 0 MARATHON OIL CORP COM 565849106 41 3017 SH DFND 1 0 0 MARATHON OIL CORP COM 565849106 1397 102172 SH DFND 0 0 0 MARATHON PETE CORP COM 56585A102 11327 183249 SH DFND 1 0 0 MARATHON PETE CORP COM 56585A102 15910 257405 SH DFND 0 0 0 MARAVAI LIFESCIENCES HLDGS I COM CL A 56600D107 368 7504 SH DFND 0 0 0 MARKEL CORP COM 570535104 1111 930 SH DFND 1 0 0 MARKEL CORP COM 570535104 5683 4755 SH DFND 0 0 0 MARKETAXESS HLDGS INC COM 57060D108 1095 2602 SH DFND 1 0 0 MARKETAXESS HLDGS INC COM 57060D108 7450 17710 SH DFND 0 0 0 MARRIOTT INTL INC NEW CL A 571903202 2720 18364 SH DFND 1 0 0 MARRIOTT INTL INC NEW CL A 571903202 217035 1465565 SH DFND 0 0 0 MARRIOTT VACATIONS WORLDWIDE COM 57164Y107 408 2593 SH DFND 0 0 0 MARSH & MCLENNAN COS INC COM 571748102 12117 80020 SH DFND 1 0 0 MARSH & MCLENNAN COS INC COM 571748102 42506 280695 SH DFND 0 0 0 MARTIN MARIETTA MATLS INC COM 573284106 12107 35434 SH DFND 1 0 0 MARTIN MARIETTA MATLS INC COM 573284106 8768 25660 SH DFND 0 0 0 MARVELL TECHNOLOGY INC COM 573874104 4816 79846 SH DFND 1 0 0 MARVELL TECHNOLOGY INC COM 573874104 220912 3662957 SH DFND 0 0 0 MASCO CORP COM 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THERAPEUTICS INC COM NEW 83587F202 145 19066 SH DFND 0 0 0 SOS LIMITED SPNSORD ADS NEW 83587W106 112 52600 SH DFND 0 0 0 SOUTHERN CO COM 842587107 4503 72664 SH DFND 1 0 0 SOUTHERN CO COM 842587107 290164 4682332 SH DFND 0 0 0 SOUTHERN COPPER CORP COM 84265V105 6499 115771 SH DFND 0 0 0 SOUTHSTATE CORPORATION COM 840441109 361 4833 SH DFND 0 0 0 SOUTHWEST AIRLS CO COM 844741108 559 10866 SH DFND 1 0 0 SOUTHWEST AIRLS CO COM 844741108 6914 134443 SH DFND 0 0 0 SOUTHWEST GAS HLDGS INC COM 844895102 241 3600 SH DFND 0 0 0 SOUTHWESTERN ENERGY CO COM 845467109 273 49200 SH DFND 0 0 0 SPDR INDEX SHS FDS DJ GLB RL ES ETF 78463X749 998 19550 SH DFND 0 0 0 SPDR SER TR S&P REGL BKG 78464A698 985 14535 SH DFND 0 0 0 SPDR SER TR SPDR BLOOMBERG 78468R663 7746 84690 SH DFND 0 0 0 SPDR SER TR BLOMBERG BRC INV 78468R200 9019 294160 SH DFND 0 0 0 SPDR SER TR DJ REIT ETF 78464A607 253 2400 SH DFND 0 0 0 SPECTRUM BRANDS HLDGS INC NE COM 84790A105 239 2500 SH DFND 0 0 0 SPECTRUM PHARMACEUTICALS INC COM 84763A108 40 18300 SH DFND 0 0 0 SPIRE INC COM 84857L101 214 3500 SH DFND 0 0 0 SPIRIT AEROSYSTEMS HLDGS INC COM CL A 848574109 300 6800 SH DFND 0 0 0 SPIRIT RLTY CAP INC NEW COM NEW 84860W300 1700 36933 SH DFND 1 0 0 SPIRIT RLTY CAP INC NEW COM NEW 84860W300 356 7726 SH DFND 0 0 0 SPLUNK INC COM 848637104 599541 4143046 SH DFND 0 0 0 SPLUNK INC COM 848637104 5246 36254 SH DFND 1 0 0 SPOTIFY TECHNOLOGY S A SHS L8681T102 7 31 SH DFND 1 0 0 SPOTIFY TECHNOLOGY S A SHS L8681T102 481 2133 SH DFND 0 0 0 SPRINGWORKS THERAPEUTICS INC COM 85205L107 7220 113800 SH DFND 1 0 0 SPRINGWORKS THERAPEUTICS INC COM 85205L107 16123 254149 SH DFND 0 0 0 SPROUT SOCIAL INC COM CL A 85209W109 318 2607 SH DFND 0 0 0 SPROUTS FMRS MKT INC COM 85208M102 211 9122 SH DFND 0 0 0 SPS COMM INC COM 78463M107 428 2654 SH DFND 0 0 0 SPX FLOW INC COM 78469X107 234 3200 SH DFND 0 0 0 SQUARE INC CL A 852234103 18786 78329 SH DFND 1 0 0 SQUARE INC CL A 852234103 63088 263040 SH DFND 0 0 0 SS&C TECHNOLOGIES HLDGS INC COM 78467J100 1069 15400 SH DFND 1 0 0 SS&C TECHNOLOGIES HLDGS INC COM 78467J100 4390 63267 SH DFND 0 0 0 SSR MNG INC COM 784730103 198 13649 SH DFND 0 0 0 STAAR SURGICAL CO COM PAR $0.01 852312305 334 2600 SH DFND 0 0 0 STAG INDL INC COM 85254J102 2004 51060 SH DFND 1 0 0 STAG INDL INC COM 85254J102 427 10865 SH DFND 0 0 0 STANLEY BLACK & DECKER INC COM 854502101 15212 86770 SH DFND 1 0 0 STANLEY BLACK & DECKER INC COM 854502101 255263 1456070 SH DFND 0 0 0 STANTEC INC COM 85472N109 1378 29341 SH DFND 1 0 0 STANTEC INC COM 85472N109 113595 2418614 SH DFND 0 0 0 STARBUCKS CORP COM 855244109 16752 151863 SH DFND 1 0 0 STARBUCKS CORP COM 855244109 233527 2117005 SH DFND 0 0 0 STARWOOD PPTY TR INC COM 85571B105 461 18871 SH DFND 0 0 0 STATE STR CORP COM 857477103 12420 146597 SH DFND 1 0 0 STATE STR CORP COM 857477103 16381 193361 SH DFND 0 0 0 STEEL DYNAMICS INC COM 858119100 778 13300 SH DFND 1 0 0 STEEL DYNAMICS INC COM 858119100 5660 96792 SH DFND 0 0 0 STELLANTIS N.V SHS N82405106 30568 1596452 SH DFND 1 0 0 STELLANTIS N.V SHS N82405106 23900 1248182 SH DFND 0 0 0 STERICYCLE INC COM 858912108 415 6100 SH DFND 0 0 0 STERIS PLC SHS USD G8473T100 1675 8199 SH DFND 1 0 0 STERIS PLC SHS USD G8473T100 210843 1032126 SH DFND 0 0 0 STERLING BANCORP DEL COM 85917A100 324 13000 SH DFND 0 0 0 STEVANATO GROUP S P A ORD SHS T9224W109 5608 221568 SH DFND 1 0 0 STEVANATO GROUP S P A ORD SHS T9224W109 8305 328119 SH DFND 0 0 0 STIFEL FINL CORP COM 860630102 483 7109 SH DFND 0 0 0 STORE CAP CORP COM 862121100 2436 76034 SH DFND 1 0 0 STORE CAP CORP COM 862121100 506 15811 SH DFND 0 0 0 STRATEGIC ED INC COM 86272C103 16205 229856 SH DFND 0 0 0 STRIDE INC COM 86333M108 34293 954182 SH DFND 0 0 0 STRYKER CORPORATION COM 863667101 7169 27183 SH DFND 1 0 0 STRYKER CORPORATION COM 863667101 31455 119276 SH DFND 0 0 0 SUMMIT HOTEL PPTYS INC COM 866082100 310 32142 SH DFND 1 0 0 SUMMIT HOTEL PPTYS INC COM 866082100 69 7200 SH DFND 0 0 0 SUMMIT MATLS INC CL A 86614U100 278 8700 SH DFND 0 0 0 SUN CMNTYS INC COM 866674104 9119 49267 SH DFND 1 0 0 SUN CMNTYS INC COM 866674104 9712 52468 SH DFND 0 0 0 SUN LIFE FINANCIAL INC. COM 866796105 1892 36770 SH DFND 1 0 0 SUN LIFE FINANCIAL INC. COM 866796105 9750 189441 SH DFND 0 0 0 SUNCOR ENERGY INC NEW COM 867224107 1965 94791 SH DFND 1 0 0 SUNCOR ENERGY INC NEW COM 867224107 8753 422274 SH DFND 0 0 0 SUNNOVA ENERGY INTL INC. COM 86745K104 140651 4269930 SH DFND 0 0 0 SUNRUN INC COM 86771W105 545 12386 SH DFND 1 0 0 SUNRUN INC COM 86771W105 153932 3498458 SH DFND 0 0 0 SUNSTONE HOTEL INVS INC NEW COM 867892101 793 66391 SH DFND 1 0 0 SUNSTONE HOTEL INVS INC NEW COM 867892101 193 16200 SH DFND 0 0 0 SUPERNUS PHARMACEUTICALS INC COM 868459108 4279 160451 SH DFND 0 0 0 SVB FINANCIAL GROUP COM 78486Q101 2406 3720 SH DFND 1 0 0 SVB FINANCIAL GROUP COM 78486Q101 116114 179498 SH DFND 0 0 0 SYNAPTICS INC COM 87157D109 388 2158 SH DFND 0 0 0 SYNCHRONY FINANCIAL COM 87165B103 1761 36032 SH DFND 1 0 0 SYNCHRONY FINANCIAL COM 87165B103 13055 267085 SH DFND 0 0 0 SYNEOS HEALTH INC CL A 87166B102 5742 65638 SH DFND 0 0 0 SYNNEX CORP COM 87162W100 302 2900 SH DFND 0 0 0 SYNOPSYS INC COM 871607107 45009 150327 SH DFND 1 0 0 SYNOPSYS INC COM 871607107 1078126 3600835 SH DFND 0 0 0 SYNOVUS FINL CORP COM NEW 87161C501 430 9800 SH DFND 0 0 0 SYSCO CORP COM 871829107 2520 32102 SH DFND 1 0 0 SYSCO CORP COM 871829107 74014 942859 SH DFND 0 0 0 TABULA RASA HEALTHCARE INC COM 873379101 8137 310435 SH DFND 0 0 0 TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 869 41752 SH DFND 0 0 0 TAKE-TWO INTERACTIVE SOFTWAR COM 874054109 1258 8165 SH DFND 1 0 0 TAKE-TWO INTERACTIVE SOFTWAR COM 874054109 7451 48364 SH DFND 0 0 0 TAL EDUCATION GROUP SPONSORED ADS 874080104 2492 514780 SH DFND 0 0 0 TANDEM DIABETES CARE INC COM NEW 875372203 13639 114246 SH DFND 1 0 0 TANDEM DIABETES CARE INC COM NEW 875372203 20791 174164 SH DFND 0 0 0 TANGER FACTORY OUTLET CTRS I COM 875465106 501 30768 SH DFND 1 0 0 TANGER FACTORY OUTLET CTRS I COM 875465106 132 8084 SH DFND 0 0 0 TAPESTRY INC COM 876030107 35 955 SH DFND 1 0 0 TAPESTRY INC COM 876030107 1372 37045 SH DFND 0 0 0 TARGA RES CORP COM 87612G101 678 13773 SH DFND 0 0 0 TARGET CORP COM 87612E106 10890 47601 SH DFND 1 0 0 TARGET CORP COM 87612E106 66951 292658 SH DFND 0 0 0 TARO PHARMACEUTICAL INDS LTD SHS M8737E108 323 5082 SH DFND 0 0 0 TAYLOR MORRISON HOME CORP COM 87724P106 211 8200 SH DFND 0 0 0 TC ENERGY CORP COM 87807B107 2935 60988 SH DFND 1 0 0 TC ENERGY CORP COM 87807B107 14354 298303 SH DFND 0 0 0 TE CONNECTIVITY LTD REG SHS H84989104 3032 22093 SH DFND 1 0 0 TE CONNECTIVITY LTD REG SHS H84989104 15720 114563 SH DFND 0 0 0 TECHNIPFMC PLC COM G87110105 194 25600 SH DFND 0 0 0 TECK RESOURCES LTD CL B 878742204 789 31688 SH DFND 1 0 0 TECK RESOURCES LTD CL B 878742204 2535 101886 SH DFND 0 0 0 TEGNA INC COM 87901J105 280 14215 SH DFND 0 0 0 TELADOC HEALTH INC COM 87918A105 1353 10673 SH DFND 1 0 0 TELADOC HEALTH INC COM 87918A105 96343 759742 SH DFND 0 0 0 TELEDYNE TECHNOLOGIES INC COM 879360105 1424 3315 SH DFND 1 0 0 TELEDYNE TECHNOLOGIES INC COM 879360105 8134 18935 SH DFND 0 0 0 TELEFLEX INCORPORATED COM 879369106 1141 3030 SH DFND 1 0 0 TELEFLEX INCORPORATED COM 879369106 7057 18742 SH DFND 0 0 0 TELLURIAN INC NEW COM 87968A104 84 21503 SH DFND 0 0 0 TELUS CORPORATION COM 87971M103 339 15436 SH DFND 1 0 0 TELUS CORPORATION COM 87971M103 3837 174595 SH DFND 0 0 0 TEMPUR SEALY INTL INC COM 88023U101 614 13235 SH DFND 0 0 0 TENABLE HLDGS INC COM 88025T102 254 5499 SH DFND 0 0 0 TENCENT MUSIC ENTMT GROUP SPON ADS 88034P109 2005 276561 SH DFND 1 0 0 TENCENT MUSIC ENTMT GROUP SPON ADS 88034P109 11854 1635071 SH DFND 0 0 0 TENET HEALTHCARE CORP COM NEW 88033G407 432 6500 SH DFND 0 0 0 TERADATA CORP DEL COM 88076W103 416 7248 SH DFND 0 0 0 TERADYNE INC COM 880770102 1519 13918 SH DFND 1 0 0 TERADYNE INC COM 880770102 294571 2698272 SH DFND 0 0 0 TERMINIX GLOBAL HOLDINGS INC COM 88087E100 60 1431 SH DFND 1 0 0 TERMINIX GLOBAL HOLDINGS INC COM 88087E100 357 8572 SH DFND 0 0 0 TERNIUM SA SPONSORED ADS 880890108 80 1880 SH DFND 1 0 0 TERNIUM SA SPONSORED ADS 880890108 8163 192995 SH DFND 0 0 0 TERRENO RLTY CORP COM 88146M101 1390 21980 SH DFND 1 0 0 TERRENO RLTY CORP COM 88146M101 291 4600 SH DFND 0 0 0 TESLA INC COM 88160R101 41169 53500 SH DFND 1 0 0 TESLA INC COM 88160R101 413679 533449 SH DFND 0 0 0 TESLA INC COM 88160R101 18457 23800 SH Put DFND 1 0 0 TESLA INC COM 88160R101 2326 3000 SH Put DFND 0 0 0 TETRA TECH INC NEW COM 88162G103 11433 76557 SH DFND 1 0 0 TETRA TECH INC NEW COM 88162G103 426102 2853234 SH DFND 0 0 0 TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 288 29328 SH DFND 1 0 0 TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 2996 304722 SH DFND 0 0 0 TEXAS CAP BANCSHARES INC COM 88224Q107 204 3400 SH DFND 0 0 0 TEXAS INSTRS INC COM 882508104 15371 79971 SH DFND 1 0 0 TEXAS INSTRS INC COM 882508104 118629 617181 SH DFND 0 0 0 TEXAS PACIFIC LAND CORPORATI COM 88262P102 510 422 SH DFND 0 0 0 TEXAS ROADHOUSE INC COM 882681109 415 4540 SH DFND 0 0 0 TEXTRON INC COM 883203101 360 5150 SH DFND 1 0 0 TEXTRON INC COM 883203101 1850 26501 SH DFND 0 0 0 TFI INTL INC COM 87241L109 595 5820 SH DFND 0 0 0 TG THERAPEUTICS INC COM 88322Q108 25629 770098 SH DFND 1 0 0 TG THERAPEUTICS INC COM 88322Q108 55825 1677432 SH DFND 0 0 0 THE TRADE DESK INC COM CL A 88339J105 5897 83879 SH DFND 1 0 0 THE TRADE DESK INC COM CL A 88339J105 8292 117960 SH DFND 0 0 0 THERAPEUTICSMD INC COM 88338N107 9 11800 SH DFND 0 0 0 THERAVANCE BIOPHARMA INC COM G8807B106 1506 203516 SH DFND 0 0 0 THERMO FISHER SCIENTIFIC INC COM 883556102 66049 115605 SH DFND 1 0 0 THERMO FISHER SCIENTIFIC INC COM 883556102 1679227 2939155 SH DFND 0 0 0 THOMSON REUTERS CORP. COM NEW 884903709 3132 28326 SH DFND 1 0 0 THOMSON REUTERS CORP. COM NEW 884903709 21003 189987 SH DFND 0 0 0 THOR INDS INC COM 885160101 434 3537 SH DFND 0 0 0 TILRAY INC COM CL 2 88688T100 323 28633 SH DFND 0 0 0 TIM S A SPONSORED ADR 88706T108 2990 1386742 SH DFND 1 0 0 TIM S A SPONSORED ADR 88706T108 5270 2443660 SH DFND 0 0 0 TIMKEN CO COM 887389104 303 4633 SH DFND 0 0 0 TJX COS INC NEW COM 872540109 5200 78805 SH DFND 1 0 0 TJX COS INC NEW COM 872540109 31789 481805 SH DFND 0 0 0 T-MOBILE US INC COM 872590104 46436 363467 SH DFND 1 0 0 T-MOBILE US INC COM 872590104 204163 1598018 SH DFND 0 0 0 TOAST INC CL A 888787108 403 8071 SH DFND 1 0 0 TOAST INC CL A 888787108 50 995 SH DFND 0 0 0 TOLL BROTHERS INC COM 889478103 1139 20604 SH DFND 1 0 0 TOLL BROTHERS INC COM 889478103 43470 786210 SH DFND 0 0 0 TOPBUILD CORP COM 89055F103 16150 78853 SH DFND 1 0 0 TOPBUILD CORP COM 89055F103 289423 1413130 SH DFND 0 0 0 TORM PLC SHS CL A G89479102 2091 271899 SH DFND 1 0 0 TORM PLC SHS CL A G89479102 21 2794 SH DFND 0 0 0 TORO CO COM 891092108 22126 227139 SH DFND 1 0 0 TORO CO COM 891092108 216608 2223681 SH DFND 0 0 0 TORONTO DOMINION BK ONT COM NEW 891160509 7554 114123 SH DFND 1 0 0 TORONTO DOMINION BK ONT COM NEW 891160509 32746 494753 SH DFND 0 0 0 TOWER SEMICONDUCTOR LTD SHS NEW M87915274 874 29228 SH DFND 0 0 0 TRACTOR SUPPLY CO COM 892356106 1555 7674 SH DFND 1 0 0 TRACTOR SUPPLY CO COM 892356106 52649 259857 SH DFND 0 0 0 TRADEWEB MKTS INC CL A 892672106 439 5433 SH DFND 1 0 0 TRADEWEB MKTS INC CL A 892672106 2729 33789 SH DFND 0 0 0 TRANE TECHNOLOGIES PLC SHS G8994E103 2985 17290 SH DFND 1 0 0 TRANE TECHNOLOGIES PLC SHS G8994E103 69551 402844 SH DFND 0 0 0 TRANSDIGM GROUP INC COM 893641100 2242 3590 SH DFND 1 0 0 TRANSDIGM GROUP INC COM 893641100 11862 18992 SH DFND 0 0 0 TRANSOCEAN LTD REG SHS H8817H100 144 38080 SH DFND 0 0 0 TRANSPORTADORA DE GAS SUR SPONSORED ADS B 893870204 69 35300 SH DFND 0 0 0 TRANSUNION COM 89400J107 12831 114247 SH DFND 1 0 0 TRANSUNION COM 89400J107 307844 2741019 SH DFND 0 0 0 TRAVEL PLUS LEISURE CO COM 894164102 329 6040 SH DFND 0 0 0 TRAVELERS COMPANIES INC COM 89417E109 4331 28489 SH DFND 1 0 0 TRAVELERS COMPANIES INC COM 89417E109 40456 266144 SH DFND 0 0 0 TRAVERE THERAPEUTICS INC COM 89422G107 8588 354163 SH DFND 0 0 0 TREX CO INC COM 89531P105 831 8154 SH DFND 0 0 0 TRI POINTE HOMES INC COM 87265H109 820 39028 SH DFND 1 0 0 TRI POINTE HOMES INC COM 87265H109 12358 587886 SH DFND 0 0 0 TRIMBLE INC COM 896239100 5429 66010 SH DFND 1 0 0 TRIMBLE INC COM 896239100 327924 3986919 SH DFND 0 0 0 TRINET GROUP INC COM 896288107 255 2700 SH DFND 0 0 0 TRIP COM GROUP LTD ADS 89677Q107 464 15383 SH DFND 1 0 0 TRIP COM GROUP LTD ADS 89677Q107 169744 5627756 SH DFND 0 0 0 TRIPADVISOR INC COM 896945201 53 1556 SH DFND 1 0 0 TRIPADVISOR INC COM 896945201 72479 2141200 SH DFND 0 0 0 TRITON INTL LTD CL A G9078F107 219 4200 SH DFND 0 0 0 TRUEBLUE INC COM 89785X101 7919 292421 SH DFND 0 0 0 TRUIST FINL CORP COM 89832Q109 5452 92964 SH DFND 1 0 0 TRUIST FINL CORP COM 89832Q109 36100 615509 SH DFND 0 0 0 TURNING POINT THERAPEUTICS I COM 90041T108 23537 354313 SH DFND 1 0 0 TURNING POINT THERAPEUTICS I COM 90041T108 54971 827509 SH DFND 0 0 0 TWILIO INC CL A 90138F102 3262 10224 SH DFND 1 0 0 TWILIO INC CL A 90138F102 126826 397513 SH DFND 0 0 0 TWIST BIOSCIENCE CORP COM 90184D100 2303 21534 SH DFND 0 0 0 TWITTER INC COM 90184L102 3392 56176 SH DFND 1 0 0 TWITTER INC COM 90184L102 83780 1387304 SH DFND 0 0 0 TWO HBRS INVT CORP COM NEW 90187B408 144 22700 SH DFND 0 0 0 TYLER TECHNOLOGIES INC COM 902252105 1376 2999 SH DFND 1 0 0 TYLER TECHNOLOGIES INC COM 902252105 6421 14000 SH DFND 0 0 0 TYSON FOODS INC CL A 902494103 8655 109639 SH DFND 1 0 0 TYSON FOODS INC CL A 902494103 8281 104907 SH DFND 0 0 0 UBER TECHNOLOGIES INC COM 90353T100 18667 416664 SH DFND 1 0 0 UBER TECHNOLOGIES INC COM 90353T100 53977 1204847 SH DFND 0 0 0 UBS GROUP AG SHS H42097107 35251 2192237 SH DFND 1 0 0 UBS GROUP AG SHS H42097107 427342 26576204 SH DFND 0 0 0 UDR INC COM 902653104 7412 139910 SH DFND 1 0 0 UDR INC COM 902653104 48603 917374 SH DFND 0 0 0 UFP INDUSTRIES INC COM 90278Q108 984 14473 SH DFND 1 0 0 UFP INDUSTRIES INC COM 90278Q108 33318 490114 SH DFND 0 0 0 UGI CORP NEW COM 902681105 503 11800 SH DFND 1 0 0 UGI CORP NEW COM 902681105 3708 87006 SH DFND 0 0 0 ULTA BEAUTY INC COM 90384S303 1727 4785 SH DFND 1 0 0 ULTA BEAUTY INC COM 90384S303 6573 18212 SH DFND 0 0 0 ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 397 4400 SH DFND 0 0 0 UMB FINL CORP COM 902788108 293 3027 SH DFND 0 0 0 UMPQUA HLDGS CORP COM 904214103 300 14802 SH DFND 0 0 0 UNDER ARMOUR INC CL A 904311107 5420 268584 SH DFND 1 0 0 UNDER ARMOUR INC CL A 904311107 421 20871 SH DFND 0 0 0 UNDER ARMOUR INC CL C 904311206 561 32035 SH DFND 0 0 0 UNIFIRST CORP MASS COM 904708104 213 1000 SH DFND 0 0 0 UNION PAC CORP COM 907818108 8556 43653 SH DFND 1 0 0 UNION PAC CORP COM 907818108 131077 668726 SH DFND 0 0 0 UNITED AIRLS HLDGS INC COM 910047109 37 783 SH DFND 1 0 0 UNITED AIRLS HLDGS INC COM 910047109 1104 23200 SH DFND 0 0 0 UNITED BANKSHARES INC WEST V COM 909907107 303 8330 SH DFND 0 0 0 UNITED CMNTY BKS BLAIRSVLE G COM 90984P303 230 7000 SH DFND 0 0 0 UNITED PARCEL SERVICE INC CL B 911312106 8574 47084 SH DFND 1 0 0 UNITED PARCEL SERVICE INC CL B 911312106 52263 287002 SH DFND 0 0 0 UNITED RENTALS INC COM 911363109 1768 5037 SH DFND 1 0 0 UNITED RENTALS INC COM 911363109 10758 30656 SH DFND 0 0 0 UNITED STATES STL CORP NEW COM 912909108 378 17200 SH DFND 0 0 0 UNITED THERAPEUTICS CORP DEL COM 91307C102 9249 50109 SH DFND 1 0 0 UNITED THERAPEUTICS CORP DEL COM 91307C102 43434 235310 SH DFND 0 0 0 UNITEDHEALTH GROUP INC COM 91324P102 74623 190978 SH DFND 1 0 0 UNITEDHEALTH GROUP INC COM 91324P102 366347 937572 SH DFND 0 0 0 UNITI GROUP INC COM 91325V108 199 16103 SH DFND 0 0 0 UNIVAR SOLUTIONS INC COM 91336L107 7332 307785 SH DFND 1 0 0 UNIVAR SOLUTIONS INC COM 91336L107 287 12057 SH DFND 0 0 0 UNIVERSAL DISPLAY CORP COM 91347P105 502 2934 SH DFND 0 0 0 UNIVERSAL HEALTH RLTY INCOME SH BEN INT 91359E105 217 3939 SH DFND 1 0 0 UNIVERSAL HEALTH RLTY INCOME SH BEN INT 91359E105 50 900 SH DFND 0 0 0 UNIVERSAL HLTH SVCS INC CL B 913903100 899 6497 SH DFND 1 0 0 UNIVERSAL HLTH SVCS INC CL B 913903100 3663 26471 SH DFND 0 0 0 UNUM GROUP COM 91529Y106 333 13300 SH DFND 0 0 0 UP FINTECH HLDG LTD SPONSORED ADS 91531W106 998 94200 SH DFND 0 0 0 UPSTART HLDGS INC COM 91680M107 29382 92851 SH DFND 0 0 0 UPWORK INC COM 91688F104 320 7109 SH DFND 0 0 0 URBAN EDGE PPTYS COM 91704F104 656 35834 SH DFND 1 0 0 URBAN EDGE PPTYS COM 91704F104 137 7458 SH DFND 0 0 0 US BANCORP DEL COM NEW 902973304 5434 91427 SH DFND 1 0 0 US BANCORP DEL COM NEW 902973304 38798 652726 SH DFND 0 0 0 US ECOLOGY INC COM 91734M103 7496 231720 SH DFND 0 0 0 US ECOLOGY INC COM 91734M103 6658 205800 SH Call DFND 0 0 0 US ECOLOGY INC *W EXP 10/17/202 91734M111 6658 205800 SH Call DFND 0 0 0 US FOODS HLDG CORP COM 912008109 65863 1900265 SH DFND 0 0 0 V F CORP COM 918204108 1580 23582 SH DFND 1 0 0 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FDS HEALTH CAR ETF 92204A504 2760 11165 SH DFND 0 0 0 VANGUARD WORLD FDS INDUSTRIAL ETF 92204A603 881 4690 SH DFND 0 0 0 VARONIS SYS INC COM 922280102 57 944 SH DFND 1 0 0 VARONIS SYS INC COM 922280102 142406 2340275 SH DFND 0 0 0 VAXART INC COM NEW 92243A200 92 11600 SH DFND 0 0 0 VBI VACCINES INC CDA COM NEW 91822J103 36 11731 SH DFND 0 0 0 VEEVA SYS INC CL A COM 922475108 11734 40720 SH DFND 1 0 0 VEEVA SYS INC CL A COM 922475108 11110 38554 SH DFND 0 0 0 VENTAS INC COM 92276F100 8108 146851 SH DFND 1 0 0 VENTAS INC COM 92276F100 43395 785999 SH DFND 0 0 0 VEON LTD SPONSORED ADR 91822M106 28819 13845580 SH DFND 0 0 0 VEONEER INC COM 92336X109 276 8100 SH DFND 0 0 0 VERACYTE INC COM 92337F107 24848 535253 SH DFND 0 0 0 VERACYTE INC COM 92337F107 14689 351732 SH DFND 1 0 0 VEREIT INC COM 92339V308 4924 108872 SH DFND 1 0 0 VEREIT INC COM 92339V308 7142 157893 SH DFND 0 0 0 VERISIGN INC COM 92343E102 3555 17341 SH DFND 1 0 0 VERISIGN INC COM 92343E102 18136 88462 SH DFND 0 0 0 VERISK 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