Restructuring (Details)	1 Months Ended		3 Months Ended	9 Months Ended
	Mar. 31, 2016 USD ($)	Jan. 31, 2016 item	Sep. 30, 2016 USD ($) item	Sep. 30, 2016 USD ($)
Restructuring activity
Severance costs			$ 1,458,065	$ 3,499,960
Proceeds from sale of equipment				152,756
Loss on sale of equipment				(153,572)
Staff reduction
Restructuring
Number of positions eliminated | item		19	8
Severance payment equal to salary period		3 months
Expected period for restructuring payments		P18M
Restructuring activity
Severance costs				3,499,960
Payments				(1,302,307)
Restructuring accrual, ending balance			$ 2,197,653	2,197,653
Laboratory equipment
Restructuring activity
Proceeds from sale of equipment	$ 152,756
Loss on sale of equipment				$ 153,572