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Commitments and Contingencies (Details)
1 Months Ended 12 Months Ended 55 Months Ended 134 Months Ended
Jul. 31, 2015
Apr. 30, 2014
USD ($)
Jan. 31, 2014
USD ($)
item
Jun. 30, 2010
USD ($)
Oct. 31, 2008
USD ($)
shares
Nov. 30, 2003
shares
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Dec. 31, 2013
USD ($)
Dec. 31, 2012
USD ($)
Dec. 31, 2011
USD ($)
Dec. 31, 2014
USD ($)
Dec. 31, 2014
USD ($)
Leases                          
Rent expense under operating lease             $ 461,466 $ 390,126          
Future minimum lease payments due             $ 309,348            
401(k) plan                          
Employee Benefit Plan                          
Minimum eligibility age of employees             21 years            
Maximum employees contribution (as a percent)             90.00%            
Vesting period             4 years            
License Agreement | Princeton University                          
Other commitments                          
Payment of license fees                         $ 100,000
Stock issued (in shares) | shares           9,734              
Expiration period of obligation to pay royalties outside the U.S.           10 years              
License Agreement | Princeton University | Direct licensed products                          
Other commitments                          
Royalty payments for net product sales (as a percent)           2.00%              
License Agreement | Princeton University | Direct licensed products | Minimum                          
Other commitments                          
Royalty payments for net product sales (as a percent)           1.00%              
License Agreement | Princeton University | Derived licensed products                          
Other commitments                          
Royalty payments for net product sales (as a percent)           0.50%              
License Agreement | Princeton University | Derived licensed products | Minimum                          
Other commitments                          
Royalty payments for net product sales (as a percent)           0.25%              
License Agreement | Princeton University | Consideration received on or before October 5, 2014                          
Other commitments                          
Non-royalty consideration received (as a percent)           2.50%              
License Agreement | WEHI                          
Other commitments                          
Payment of license fees     $ 1,000,000                    
Royalty payments for net product sales (as a percent)     2.00%                    
Term of agreement     5 years                    
Obligation under the agreement     $ 1,250,000                    
Non-royalty consideration received from sublicensee (as a percent)     15.00%                    
Potential milestone payment     $ 3,750,000                    
Potential subsequent milestone payments     $ 1,875,000                    
Number of subsequent indications | item     2                    
License Agreement | Licensors                          
Other commitments                          
Payment of license fees   $ 213,317                      
Stock issued (in shares) | shares         400,000                
Potential milestone payment         $ 4,450,000                
License maintenance fee payment             $ 50,000 50,000 $ 50,000 $ 100,000      
Milestone payment                     $ 100,000    
Required written notice         60 days                
License Agreement | LLS                          
Other commitments                          
Potential milestone payment       $ 8,085,000                  
Payment received                       $ 2,695,000  
Multiple to determine maximum payment       3                  
Fair value of potential obligation             $ 200,000 $ 200,000       $ 200,000 $ 200,000
birinapant and SHAPE                          
Other commitments                          
Term of agreement 10 years