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Stockholders’ Equity (SBC) (Details) - USD ($)
1 Months Ended 12 Months Ended
Jan. 31, 2015
Oct. 31, 2013
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Stock-based compensation          
Number of shares of common stock available for issuance     1,724,893    
Stock-based compensation expense     $ 5,680,353 $ 3,384,800  
Research and development          
Stock-based compensation          
Stock-based compensation expense     1,569,886 933,814  
General and administrative          
Stock-based compensation          
Stock-based compensation expense     4,110,467 2,450,986  
Options awards          
Stock-based compensation          
Stock-based compensation expense     $ 4,933,916 $ 3,299,870  
Additional disclosures          
Contractual life     7 years 6 months    
Shares          
Outstanding at the beginning of the period (in shares) 3,277,308   3,277,308 3,263,417  
Granted (in shares)     785,900 253,750  
Exercised (in shares)     (24,261) (121,816)  
Forfeited (in shares)     (18,164) (118,043)  
Outstanding at the end of the period (in shares)     4,020,783 3,277,308 3,263,417
Vested and expected to vest (in shares)     3,965,121    
Exercisable (in shares)     2,612,588    
Weighted-Average Exercise Price Per Share          
Outstanding at beginning of the period (in dollars per share) $ 5.53   $ 5.53 $ 5.36  
Granted (in dollars per share)     5.15 5.77  
Exercised (in dollars per share)     1.35 1.49  
Forfeited (in dollars per share)     5.51 5.56  
Outstanding at the end of the period (in dollars per share)     5.48 $ 5.53 $ 5.36
Vested and expected to vest at the end of the period (in dollars per share)     5.48    
Exercisable at the end of the period (in dollars per share)     $ 5.41    
Weighted-Average Contractual Life (In Years)          
Outstanding at the end of the period     7 years 9 months 18 days 8 years 6 months 9 years
Vested and expected to vest at the end of the period     7 years 9 months 18 days    
Exercisable at the end of the period     7 years 6 months    
Fair Value of Options Granted          
Granted     $ 2,944,407 $ 1,145,545  
Aggregate Intrinsic Value          
Aggregate intrinsic value         $ 13,575,815
Options awards | Executive Officers          
Additional disclosures          
Vesting (as a percent) 2.00%        
Minimum closing price (in dollars per share) $ 20.00        
Consecutive trading days 5 days        
Shares          
Granted (in shares) 600,000        
Restricted stock awards          
Stock-based compensation          
Stock-based compensation expense     $ 746,437 $ 84,930  
Restricted stock awards | Executive Officers          
Additional disclosures          
Minimum closing price (in dollars per share) $ 20.00        
Consecutive trading days 5 days        
Vesting period 3 years        
2004 Plan          
Stock-based compensation          
Number of additional shares of common stock authorized for issuance   1,847,738      
2013 Plan          
Stock-based compensation          
Number of authorized shares of common stock for issuance         3,659,158