Income Taxes (Details Textual) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Tax Credit Carryforward [Line Items]
Valuation allowance, deferred tax asset, increase (decrease), amount	$ 41,340	$ 14,943
Unrecognized tax benefits	9,540	$ 4,690	$ 3,201
Unrecognized tax benefits that would impact effective tax rate	5,762
Unrecognized tax benefits, income tax penalties and interest expense	578
Domestic Tax Authority
Tax Credit Carryforward [Line Items]
Operating loss carryforwards	318,321
Operating loss carryforwards, subject to expiration	22,907
State and Local Jurisdiction
Tax Credit Carryforward [Line Items]
Operating loss carryforwards	201,029
Operating loss carryforwards, subject to expiration	172,131
Foreign Tax Authority
Tax Credit Carryforward [Line Items]
Operating loss carryforwards	3,870
Deferred income tax liabilities	$ 97
Israel Tax Authority | Foreign Tax Authority | VSL | Minimum
Tax Credit Carryforward [Line Items]
Tax rate for amount of dividends distributed, other than complete liquidation	10.00%
Israel Tax Authority | Foreign Tax Authority | VSL | Maximum
Tax Credit Carryforward [Line Items]
Tax rate for amount of dividends distributed, other than complete liquidation	25.00%
Research Tax Credit Carryforward | Domestic Tax Authority
Tax Credit Carryforward [Line Items]
Tax credit carryforward, amount	$ 1,412
Retention | Domestic Tax Authority
Tax Credit Carryforward [Line Items]
Tax credit carryforward, amount	24
Foreign Tax Credit | Domestic Tax Authority
Tax Credit Carryforward [Line Items]
Tax credit carryforward, amount	190
Ireland Employment | Domestic Tax Authority
Tax Credit Carryforward [Line Items]
Tax credit carryforward, amount	$ 19