Stockholders' Equity (Details Textual) $ / shares in Units, $ in Thousands					12 Months Ended			72 Months Ended	96 Months Ended
	Mar. 12, 2021	Feb. 16, 2021 USD ($) $ / shares shares	Jun. 30, 2015 shares	Nov. 14, 2013 shares	Dec. 31, 2021 USD ($) vote shares	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)	Dec. 31, 2021 ؋ / shares shares	Dec. 31, 2021 ؋ / shares shares	Dec. 31, 2021 USD ($) $ / shares shares	Dec. 31, 2020 ؋ / shares	Dec. 31, 2020 USD ($) $ / shares shares	Dec. 31, 2013 shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Common stock, shares authorized (in shares)										200,000,000		200,000,000
Common stock, par value (in usd per share) | (per share)								؋ 0.001	؋ 0.001	$ 0.001	؋ 0.001	$ 0.001
Number of voting rights | vote					1
Stock split, conversion ratio	3
Granted (in shares)					0
Exercises in period, intrinsic value | $					$ 13,153	$ 9,922	$ 12,453
Compensation cost not yet recognized | $										$ 496		$ 810
Public Stock Offering
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Sale of stock, number of shares issued in transaction (shares)		7,961,538
Sale of stock, price per share (usd per share) | $ / shares		$ 65.00
Sale of stock, consideration received on transaction | $		$ 500,034
Payments of stock issuance costs | $		$ 17,466
Public Stock Offering - Additional Optional Shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Sale of stock, number of shares issued in transaction (shares)		1,038,459
Share-based Payment Arrangement, Option
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation cost not yet recognized, period for recognition					1 year 9 months 18 days	2 years 8 months 19 days
Performance Shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period (years)					3 years
Restricted Stock Units and Performance Stock Units
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation cost not yet recognized | $										$ 265,345		$ 141,408
Compensation cost not yet recognized, period for recognition					2 years 29 days	2 years 1 month 13 days
The 2005 Stock Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Common stock, capital shares reserved for future issuance (in shares)													14,139,957
Vesting period (in years)					4 years
Granted (in shares)					0				0
Available for grant (in shares)										0
The 2005 Stock Plan | Consultants
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Granted (in shares)					0
The 2013 Omnibus Equity Award Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Common stock, capital shares reserved for future issuance (in shares)				5,713,899
Vesting period (in years)					4 years
Granted (in shares)					0
Percentage of outstanding stock reserved for grant				4.00%
Percentage of outstanding stock maximum				5.00%
Capital shares reserved for future issuance, annual increase, maximum (in shares)										24,217,741
The 2013 Omnibus Equity Award Plan | Consultants
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Granted (in shares)					0
The 2013 Omnibus Equity Award Plan | Performance Shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period (in years)					1 year
2015 ESPP
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Maximum employee subscription rate			15.00%
Purchase price of common stock, percent			85.00%
Number of shares authorized (in shares)			1,500,000
Percent of shares increase, employee stock purchase plan			1.00%
Common stock availability threshold, employee stock purchase plan			2.00%
Shares increase threshold, employee stock purchase plan (in shares)			1,200,000
Number of additional shares authorized (in shares)								3,004,765