X0306 4 2016-02-22 1 0001360886 OSIRIS THERAPEUTICS, INC. OSIR 0001370936 Debrabandere Lode 7015 ALBERT EINSTEIN DRIVE COLUMBIA MD 21046 0 1 0 0 President & CEO Incentive Stock Option (right to buy) 5.08 2016-02-22 4 D 0 6250 5.08 D 2016-03-23 2022-03-23 Common Stock 6250 403750 D Incentive Stock Option (right to buy) 7.73 2016-02-22 4 D 0 7500 7.73 D 2017-02-12 2023-02-12 Common Stock 7500 396250 D Non-Qualified Stock Option (right to buy) 14.93 2016-02-22 4 D 0 34686 14.93 D 2017-02-06 2024-02-06 Common Stock 34686 361564 D Non-Qualified Stock Option (right to buy) 14.93 2016-02-22 4 D 0 30803 14.93 D 2018-02-06 2024-02-06 Common Stock 30803 330761 D Incentive Stock Option (right to buy) 14.93 2016-02-22 4 D 0 2814 14.93 D 2017-02-06 2024-02-06 Common Stock 2814 327947 D Incentive Stock Option (right to buy) 14.93 2016-02-22 4 D 0 6697 14.93 D 2018-02-06 2024-02-06 Common Stock 6697 321250 D Non-Qualified Stock Options 18.40 2016-02-22 4 D 0 18750 18.40 D 2016-03-06 2025-03-06 Common Stock 18750 302500 D Non-Qualified Stock Option 18.40 2016-02-22 4 D 0 18750 18.40 D 2017-03-06 2025-03-06 Common Stock 18750 283750 D Non-Qualified Stock Option (right to buy) 18.40 2016-02-22 4 D 0 18750 18.40 D 2018-03-06 2025-03-06 Common Stock 18750 265000 D Non-Qualified Stock Option (right to buy) 18.40 2016-02-22 4 D 0 13316 18.40 D 2019-03-06 2025-03-25 Common Stock 13316 251684 D Incentive Stock Option (right to buy) 18.40 2016-02-22 4 D 0 5434 18.40 D 2019-03-06 2025-03-06 Common Stock 5434 246250 D Unvested incentive stock option that were forfeited concurrent with the Reporting Person's execution of post-resignation separation agreement, consistent with the provisions of the Amended and Restated 2006 Omnibus Plan. The Reporting Person's stock options that were vested on the date that he executed the separation agreement will remain exercisable for 90 days from the resignation date. The expiration of certain options were extended to one year as detailed in the separation agreement disclosed in the related Form 8-K. Unvested non-qualified stock option that were forfeited concurrent with the Reporting Person's execution of post-resignation separation agreement, consistent with the provisions of the Amended and Restated 2006 Omnibus Plan. The Reporting Person's stock options that were vested on the date that he executed the separation agreement will remain exercisable for 90 days from the resignation date. The expiration of certain options were extended to one year as detailed in the separation agreement disclosed in the related Form 8-K. Lode Debrabandere 2016-02-24