X0306 4 2019-08-28 0 0001358762 REATA PHARMACEUTICALS INC RETA 0001569769 Soni Manmeet Singh 2801 GATEWAY DRIVE SUITE 150 IRVING TX 75063 0 1 0 0 Chief Financial Officer Employee Stock Option (right to buy) 72.70 2019-08-28 4 A 0 250000 0.00 A 2029-08-28 Class B common stock 250000 250000 D The option, representing a right to purchase a total of 250,000 shares, becomes exercisable as to 62,500 shares on August 28, 2020, with the remainder to vest in twelve equal quarterly installments thereafter, subject to continued service through each vesting date. The Class B common stock is convertible into Class A common stock on a one-for-one basis at the holder's election at any time. The conversion right of the Class B common stock has no expiration date. /s/ Michael D. Wortley, attorney-in-fact 2019-08-29