SHARE-BASED COMPENSATION PLANS (Tables)

12 Months Ended

Dec. 31, 2021

Share-based Payment Arrangement [Abstract]

Schedule of Outstanding Awards

At December 31, 2021 and 2020, outstanding awards were comprised of the following:

	December 31, 2021	December 31, 2020
Options	2,074,858	1,425,207
Inducement option awards	65,760	85,761
Restricted stock units	137,004	129,361
Inducement restricted stock units	500	500
Total outstanding awards	2,278,122	1,640,829

Weighted-Average Valuation Assumptions

The fair value of the option grants has been estimated, with the following weighted-average assumptions:

	Year Ended
	December 31, 2021		December 31, 2020
Options granted	1,023,000		1,352,595
Weighted-average exercise price	2.80		7.59
Weighted-average grant date fair value	2.02		5.29
Assumptions:
Risk-free interest rate	0.92	%	0.82	%
Volatility	90	%	85	%
Expected life (years)	5.63		5.83
Expected dividend yield	—		—

Schedule of Stock Option Activity

The following table summarizes the stock option activity for all stock plans during the year ended December 31, 2021 and 2020 as follows:

Options	Outstanding Stock Options	Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (in years)	Aggregate Intrinsic Value (in thousands)
Balance at December 31, 2019	567,842	$	76.25	7.82	$	12
Granted	1,352,595	$	7.59
Exercised	—
Forfeited	(409,469)	$	29.86
Balance at December 31, 2020	1,510,968	$	27.36	8.19	$	379
Granted	1,023,000	$	2.80
Exercised	—
Forfeited	(393,350)	$	30.66
Balance at December 31, 2021	2,140,618	$	15.01	8.48	$	—
Exercisable at December 31, 2021	718,123	$	36.42	6.98	$	—

Summary of Options Outstanding and Exercisable

The following table summarizes the options outstanding and exercisable at December 31, 2021:

Options Outstanding					Options Exercisable
Exercise Price	Total Shares	Weighted Average Remaining Contractual Term (in years)	Weighted Average Exercise Price		Total Shares	Weighted Average Remaining Contractual Term (in years)	Weighted Average Exercise Price
$1.73 to $2.87	215,000	9.89	$	1.81	—	0.00	$	—
$2.88 to $2.93	665,000	9.62	$	2.88	—	0.00	$	—
$2.94 to $3.01	506,000	8.95	$	2.97	253,000	8.95	$	2.97
$3.02 to $16.15	475,076	7.32	$	9.97	207,374	6.15	$	11.97
$16.16 to $234.70	279,542	5.82	$	84.39	257,749	5.71	$	88.94
Total	2,140,618	8.48	$	15.01	718,123	6.98	$	36.42

Schedule of Restricted Stock Unit Activity

The following table summarizes the stock award activity for all restricted stock units during the year ended December 31, 2021:

Awards	Outstanding Restricted Stock Awards and Units	Weighted-Average Grant Date Fair Value Per Share		Outstanding Aggregate Intrinsic Value (in thousands)		Total Fair Value of Restricted Awards Vested (in thousands)
Balance at December 31, 2019	6,359	$	92.29	$	82
Granted	239,023	$	4.70
Vested	(2,309)	$	96.14	$	30	$	222
Forfeited	(113,212)	$	6.73
Balance at December 31, 2020	129,861	$	5.59	$	458
Granted	136,626	$	3.54
Vested	(126,477)	$	5.05	$	413	$	659
Forfeited	(2,506)	$	4.85
Balance at December 31, 2021	137,504	$	4.06	$	205

Summary of ESPP Activity

A summary of activity within the ESPP follows:

	Year Ended
(in thousands except share data)	December 31, 2021		December 31, 2020
Deductions from employees	$	—	$	56
Share-based compensation expense recognized	$	—	$	96
Proceeds received by the Company for ESPP	$	—	$	78
Weighted-average purchase price per common share	$	—	$	5.21

Schedule Share-based Compensation

Share-based compensation expense by classification for December 31, 2021 and 2020 are as follows:

	Year Ended
(in thousands)	December 31, 2021		December 31, 2020
General and administrative	$	2,275	$	3,170
Research and development	1,164		1,861
Total	$	3,439	$	5,031