STOCKHOLDERS' EQUITY AND SHARE-BASED COMPENSATION PLANS (Tables)

12 Months Ended

Dec. 31, 2019

Share-based Payment Arrangement [Abstract]

Schedule of Outstanding Awards

At December 31, 2019 and 2018, outstanding awards were comprised of the following:

	December 31, 2019	December 31, 2018
Options	471,282	401,535
Inducement option awards	96,560	122,500
Restricted stock units	5,609	19,490
Inducement restricted stock units outstanding	750	5,125
Total outstanding awards	574,201	548,650

Weighted-Average Valuation Assumptions

The fair value of the option grants has been estimated, with the following weighted-average assumptions:

	Year Ended
	December 31, 2019		December 31, 2018
Options granted	276,830		262,319
Weighted-average exercise price	26.12		68.79
Weighted-average grant date fair value	16.99		45.10
Assumptions:
Risk-free interest rate	2.23	%	2.67	%
Volatility	72	%	72	%
Expected life (years)	6.04		6.08
Expected dividend yield	—	%	—	%

Schedule of Stock Option Activity

The following table summarizes the stock option activity for all stock plans during the year ended December 31, 2019 and 2018 as follows:

Options	Outstanding Stock Options		Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (in years)	Aggregate Intrinsic Value (in thousands)
Balance at December 31, 2017	528,647		$	123.51	7.35	$	7,223
Granted	262,319		$	68.79
Exercised	(104,445	)	$	31.99
Forfeited	(110,597	)	$	155.64
Balance at December 31, 2018	575,924		$	109.01	8.09	$	87
Granted	276,830		$	26.12
Exercised	(220	)	$	25.50
Forfeited	(284,692	)	$	93.81
Balance at December 31, 2019	567,842		$	76.25	7.82	$	12
Exercisable at December 31, 2019	271,356		$	109.26	6.66	$	5

Summary of Options Outstanding and Exercisable

The following table summarizes the options outstanding and exercisable at December 31, 2019:

Options Outstanding					Options Exercisable
Exercise Price	Total Shares	Weighted Average Remaining Contractual Term (in years)	Weighted Average Exercise Price		Total Shares	Weighted Average Remaining Contractual Term (in years)	Weighted Average Exercise Price
$5.10 to $27.99	116,935	8.23	$	19.72	19,560	2.12	$	24.78
$28.00 to $34.59	114,298	9.05	$	33.66	12,550	8.97	$	33.91
$34.60 to $78.49	112,977	7.78	$	68.77	68,586	7.22	$	70.77
$78.50 to $117.99	91,960	7.84	$	96.55	57,690	7.72	$	99.18
$118.00 to $234.70	131,672	6.42	$	155.68	112,970	6.32	$	160.77
Total	567,842	7.82	$	76.25	271,356	6.66	$	109.26

Stock Award Activity For All Stock Plans

The following table summarizes the stock award activity for all stock plans during the year ended December 31, 2019:

Awards	Outstanding Restricted Stock Awards and Units		Weighted-Average Grant Date Fair Value Per Share		Outstanding Aggregate Intrinsic Value (in thousands)		Total Fair Value of Restricted Awards Vested (in thousands)
Balance at December 31, 2017	14,066		$	138.69	$	1,183
Granted	21,125		$	71.36
Vested	(5,723	)	$	158.47	$	420	$	907
Forfeited	(4,853	)	$	118.85
Balance at December 31, 2018	24,615		$	80.23	$	719
Granted	3,000		$	33.30
Vested	(14,478	)	$	64.16	$	240	$	929
Forfeited	(6,778	)	$	82.44
Balance at December 31, 2019	6,359		$	92.29	$	82

Summary of ESPP Activity

A summary of activity within the ESPP follows:

	Year Ended
(in thousands except share data)	December 31, 2019		December 31, 2018
Deductions from employees	$	70	$	221
Share-based compensation expense recognized	$	95	$	138
Remaining share-based compensation expense	$	206	$	464
Proceeds received by the Company for ESPP	$	98	$	205
Weighted-average purchase price per common share	$	12.25	$	45.30
Number of shares purchased by employees under ESPP	8,000		4,539

Schedule Share-based Compensation

Share-based compensation expense by classification for December 31, 2019 and 2018 are as follows:

	Year Ended
(in thousands)	December 31, 2019		December 31, 2018
General and administrative	$	4,017	$	7,479
Research and development	3,321		6,345
Total	$	7,338	$	13,824