X0508 4 2026-02-18 0001401667 PUMA BIOTECHNOLOGY, INC. PBYI 0001358285 AUERBACH ALAN H C/O PUMA BIOTECHNOLOGY, INC. 10880 WILSHIRE BLVD., SUITE 1700 LOS ANGELES CA 90024 1 1 1 President and CEO 0 Common Stock 2026-02-18 4 A 0 159778 0 A 7305729 D Stock Option (Right to Buy) 6.68 2026-02-18 4 A 0 227474 0 A 2036-02-17 Common Stock 227474 227474 D Represents the grant of Restricted Stock Units ('RSUs"). Subject to the Reporting Person's continued status as an Employee of the Company, the RSUs shall vest with respect to one-fourth (1/4th) of the RSUs on each of July 1, 2026, January 1, 2027, July 1, 2027 and January 1, 2028, subject to acceleration in certain events. Subject to the Reporting Person's continued status as an Employee of the Company, the Options shall vest and become exercisable with respect to one-fourth (1/4th) of the shares of Common Stock subject thereto on each of July 1, 2026, January 1, 2027, July 1, 2027 and January 1, 2028, subject to acceleration in certain events. /s/ Gordon Esplin as attorney-in-fact for Alan H. Auerbach 2026-02-20