X0306 4 2018-02-11 0 0001401667 PUMA BIOTECHNOLOGY, INC. PBYI 0001358246 EYLER CHARLES R C/O PUMA BIOTECHNOLOGY, INC. 10880 WILSHIRE BLVD., SUITE 2150 LOS ANGELES CA 90024 0 1 0 0 SEE REMARKS COMMON STOCK 2018-02-11 4 A 0 9000 0.00 A 37027 D STOCK OPTION (RIGHT TO BUY) 60.85 2018-02-11 4 A 0 14000 0.00 A 2028-02-10 COMMON STOCK 14000 14000 D Represents Restricted Stock Units which vest (i) with respect to one-third (1/3rd) of the shares subject thereto on the first anniversary of the vesting commencement date of January 1, 2018 ("Vesting Commencement Date") and (ii) with respect to 1/36th of the shares subject thereto on each monthly anniversary of the Vesting Commencement Date thereafter, subject to Reporting Person's continued service with the Issuer through the applicable vesting date. The vesting commencement date ("Vesting Commencement Date") of the option is January 1, 2018. The option vests (i) with respect to one-third (1/3rd) of the shares underlying the option on the first anniversary of the Vesting Commencement Date and (ii) with respect to 1/36th of the shares underlying the option on each monthly anniversary of the Vesting Commencement Date thereafter, subject to Reporting Person's continued service with the Issuer through the applicable vesting date. Title of Reporting Person: Senior Vice President, Finance and Administration and Treasuer /s/ Charles R. Eyler 2018-02-13