<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <previousAccessionNumber>0001591986-24-000004</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001591986</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>2</amendmentNo>
      <securitiesClassTitle>Common Stock, par value $0.000005 per share</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>06/30/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001357874</issuerCik>
        <issuerName>PRECISION BIOSCIENCES INC</issuerName>
        <issuerCusip>74019P207</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>302 EAST PETTIGREW STREET</com:street1>
          <com:street2>SUITE A-100</com:street2>
          <com:city>DURHAM</com:city>
          <com:stateOrCountry>NC</com:stateOrCountry>
          <com:zipCode>27701</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(b)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>Aquilo Capital, L.P.</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>0.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>0.0</classPercent>
      <typeOfReportingPerson>PN</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>Aquilo Capital Management, LLC</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>0.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>0.0</classPercent>
      <typeOfReportingPerson>IA</typeOfReportingPerson>
      <typeOfReportingPerson>HC</typeOfReportingPerson>
      <typeOfReportingPerson>OO</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>Marc Schneidman</reportingPersonName>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>0.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>0.0</classPercent>
      <typeOfReportingPerson>HC</typeOfReportingPerson>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>PRECISION BIOSCIENCES INC</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>302 EAST PETTIGREW STREET, SUITE A-100, DURHAM, NORTH CAROLINA, 27701.</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>This statement is filed by the entities and persons listed below, who are collectively referred to herein as "Reporting Persons", with respect to the Common Stock (as defined in Item 2(d) below) of the Company:

(i)	Aquilo Capital, L.P.

(ii)	Aquilo Capital Management, LLC

(iii)	Marc Schneidman</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>(i)	Aquilo Capital, L.P.
One Letterman Drive, Suite D4900
Building D, The Presidio
San Francisco, CA 94129

(ii)	Aquilo Capital Management, LLC
One Letterman Drive, Suite D4900
Building D, The Presidio
San Francisco, CA 94129

(iii)	Marc Schneidman
c/o Aquilo Capital Management, LLC
One Letterman Drive, Suite D4900
Building D, The Presidio
San Francisco, CA 94129</principalBusinessOfficeOrResidenceAddress>
        <citizenship>(i)	Aquilo Capital, L.P. - DE

(ii)	Aquilo Capital Management, LLC - CA

(iii)	Marc Schneidman - USA</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>N</notApplicableFlag>
        <typeOfPersonFiling>IA</typeOfPersonFiling>
        <typeOfPersonFiling>HC</typeOfPersonFiling>
      </item3>
      <item4>
        <amountBeneficiallyOwned>Aquilo Capital L.P.
Amount beneficially owned: 0

Aquilo Capital Management, LLC
Amount beneficially owned: 0

Marc Schneidman
Amount beneficially owned: 0</amountBeneficiallyOwned>
        <classPercent>Aquilo Capital L.P.
Percent of Class: 0%

Aquilo Capital Management, LLC
Percent of Class: 0%

Marc Schneidman
Percent of Class: 0%</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>Aquilo Capital L.P.
Sole power to vote or to direct the vote: 0

Aquilo Capital Management, LLC
Sole power to vote or to direct the vote: 0

Marc Schneidman
Sole power to vote or to direct the vote: 0</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>Aquilo Capital L.P.
Shared power to vote or to direct the vote: 0

Aquilo Capital Management, LLC
Shared power to vote or to direct the vote: 0

Marc Schneidman
Shared power to vote or to direct the vote: 0</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>Aquilo Capital L.P.
Sole power to dispose or to direct the disposition of: 0

Aquilo Capital Management, LLC
Sole power to dispose or to direct the disposition of: 0

Marc Schneidman
Sole power to dispose or to direct the disposition of: 0</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>Aquilo Capital L.P.
Shared power to dispose or to direct the disposition of: 0

Aquilo Capital Management, LLC
Shared power to dispose or to direct the disposition of: 0

Marc Schneidman
Shared power to dispose or to direct the disposition of: 0</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <classOwnership5PercentOrLess>Y</classOwnership5PercentOrLess>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under &amp;#167; 240.14a-11.

</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>Aquilo Capital, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Marc Schneidman</signature>
        <title>Aquilo Capital Management, LLC, its General Partner</title>
        <date>08/06/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Aquilo Capital Management, LLC</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Marc Schneidman</signature>
        <title>Managing Member</title>
        <date>08/06/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Marc Schneidman</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Marc Schneidman</signature>
        <title>Marc Schneidman</title>
        <date>08/06/2025</date>
      </signatureDetails>
    </signatureInformation>
  </formData>

</edgarSubmission>
