X0508 4 2024-01-20 0 0001357874 PRECISION BIOSCIENCES INC DTIL 0001770169 SMITH J. JEFFERSON C/O PRECISION BIOSCIENCES, INC. 302 E. PETTIGREW STREET, SUITE A-100 DURHAM NC 27701 0 1 0 0 Chief Research Officer 0 Common Stock 2024-01-20 4 M 0 75015 A 2015269 D Common Stock 2024-01-23 4 S 0 28000 0.37 D 1987269 D Common Stock 237959 I By Charitable Remainder Unitrust Restricted Stock Units 2024-01-20 4 M 0 75015 0.00 D Common Stock 75015 149985 D Represents the partial vesting and settlement of Restricted Stock Units ("RSUs") on January 20, 2024. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock or, at the Issuer's option, an amount of cash equal to the fair market value of such share. The transaction was a sell-to-cover, with shares sold to cover tax withholding obligations in connection with the vesting and settlement of RSUs. The reporting person did not sell or otherwise dispose of shares reported on this Form 4 for any reason other than to cover required taxes and fees. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $0.35495 to $0.37790. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the range set forth in this footnote. On January 20, 2023 the Reporting Person was granted RSUs, which vest in three substantially equal annual installments beginning on January 20, 2024, subject to the Reporting Person's continued service to the Issuer through the applicable vesting dates. /s/ Dario Scimeca, Attorney-in-Fact for J. Jefferson Smith 2024-01-23