X0306 4 2020-08-21 0 0001357874 PRECISION BIOSCIENCES INC DTIL 0001769887 KANE MATTHEW R. C/O PRECISION BIOSCIENCES, INC. 302 E. PETTIGREW STREET, SUITE A-100 DURHAM NC 27701 1 1 0 0 President and CEO Employee Stock Option (Right to Buy) 5.83 2020-08-21 4 A 0 1743 0.00 A 2030-08-20 Common Stock 1743 1743 I By Spouse The option vests as to 25% of the underlying shares on April 1, 2021 and thereafter in twelve equal installments at the end of each three-month period over the 36 months following such date. Employee Stock Option is held by Chelsea Lynam Kane, the spouse of the reporting person. The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein. /s/ Dario Scimeca, Attorney-in-Fact for Matthew Kane 2021-06-11