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Note 4 - Stockholders' Equity (Tables)
9 Months Ended 12 Months Ended
Sep. 30, 2020
Dec. 31, 2019
Notes Tables    
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
    Three Months Ended September 30,
    2020   2019
         
Research and development expenses   $
26,251
    $
 
General and administrative expenses    
180,571
     
294,600
 
Total   $
206,822
    $
294,600
 
    Nine Months Ended September 30,
    2020   2019
         
Research and development expenses   $
26,251
    $
200,337
 
General and administrative expenses    
497,710
     
561,007
 
Total   $
523,961
    $
761,344
 
    Year Ended December 31,
    2019   2018
         
Research and development costs   $
200,337
    $
133,334
 
General and administrative expenses    
680,452
     
500,748
 
Total   $
880,789
    $
634,082
 
Share-based Payment Arrangement, Option, Activity [Table Text Block]
    Number of Options   Weighted-Average
Exercise Price
  Weighted-Average
Remaining
Contractual Life
(in years)
  Aggregate
Intrinsic Value
                 
Outstanding at January 1, 2020    
271,660
    $
61.83
     
7.8
    $  
Granted    
1,686,466
    $
0.62
     
 
         
Exercised    
    $
     
 
    $  
Forfeited    
(157,204
)   $
15.53
     
 
         
Outstanding at September 30, 2020    
1,800,922
    $
8.55
     
9.3
    $  
                                 
Exercisable at September 30, 2020    
710,884
    $
20.63
     
8.9
    $  
    Number of Options   Weighted-Average Exercise Price   Weighted-Average Remaining Contractual Life (in years)   Aggregate Intrinsic Value
                 
Outstanding at January 1, 2019    
81,674
    $
215.60
     
5.1
    $
-
 
Granted    
228,183
    $
7.78
     
 
    $
-
 
Exercised    
-
     
-
     
 
     
 
 
Forfeited/Expired    
(38,197
)   $
67.90
     
 
     
 
 
Outstanding at December 31, 2019    
271,660
    $
61.83
     
7.8
    $
-
 
                                 
Exercisable at December 31, 2019    
207,813
    $
78.30
     
7.4
    $
-
 
Share-based Payment Arrangement, Option, Exercise Price Range [Table Text Block]
Range of Exercise Prices   Number of Options
Outstanding
  Weighted-Average
Exercise Price
  Weighted-Average
Remaining
Contractual Life
(in years)
  Aggregate
Intrinsic Value
 
$0.62
 
   
1,686,466
    $
0.62
     
9.5
    $  
$5.90
-
$6.00
   
45,378
    $
5.99
     
8.8
       
$7.20
-
$8.80
   
6,380
    $
8.69
     
8.4
       
$22.20
-
$80.60
   
24,488
    $
31.15
     
4.8
       
$107.40
-
$1,102.40
   
38,210
    $
347.18
     
2.0
       
 
 
 
   
1,800,922
    $
8.55
     
9.3
    $  
Range of Exercise Prices   Number of Options Outstanding   Weighted-Average Exercise Price   Weighted-Average Remaining Contractual Life (in years)   Aggregate Intrinsic Value
$5.90
-
$6.00
   
55,484
    $
5.99
     
9.5
    $
-
 
$7.20
-
$8.80
   
146,972
    $
8.51
     
9.0
     
-
 
$22.20
-
$99.20
   
28,501
    $
31.63
     
5.7
     
-
 
$107.40
-
$1,102.41
   
40,703
    $
351.63
     
2.8
     
-
 
 
 
 
   
271,660
    $
61.83
     
7.8
    $
-
 
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
    Nine Months Ended September 30,
    2020   2019
Annual dividend  
 
-
 
 
 
-
 
Expected life (in years)  
4.0
-
5.2
 
 4.8
-
5.5 
Risk free interest rate  
0.2%
-
0.3%
 
1.8%
-
2.5%
Expected volatility  
110%
-
111%
 
97%
-
115%
     
Year Ended December 31, 
 
 
 
 
2019
 
 
 
2018
 
                 
Annual dividend    
 
-
 
     
 
-
 
 
Expected life (in years)    
4.8
-
5.5
     
2.5
-
5.3
 
Risk free interest rate    
1.8%
-
2.5%
     
2.5%
-
2.8%
 
Expected volatility    
97%
-
115%
     
97%
-
113%
 
Schedule of Share-based Compensation, Warrant Activity [Table Text Block]
Range of Exercise Prices   Number of
Warrants Outstanding
  Range of Expiration Dates
$0.90
-
$1.25
   
3,233,407
   
May 2021
-
May 2025
$1.70
-
$3.38
   
1,493,999
   
December 2020
-
January 2025
$6.00
-
$782.60
   
199,337
   
October 2020
-
April 2024
 
 
 
   
4,926,743
   
 
 
 
Range of Exercise Prices   Number of Warrants Outstanding   Range of Expiration Dates
$2.19
-
$2.70
   
6,538,035
   
December 2020
-
August 2024
$3.38
-
$17.50
   
406,223
   
October 2023
-
July 2024
$22.20
-
$782.60
   
24,650
   
March 2020
-
July 2023
 
   
6,968,908
   
 
Restricted Stock [Member]    
Notes Tables    
Share-based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block]  
    Shares of Restricted Stock   Weighted-Average Grant Date Fair Value
         
Outstanding at January 1, 2019    
1,127
    $
22.20
 
Granted    
15,689
    $
5.95
 
Vested    
(8,835
)   $
8.03
 
Forfeited    
-
    $
-
 
Outstanding at December 31, 2019    
7,981
    $
5.95
 
Restricted Stock Units (RSUs) [Member]    
Notes Tables    
Share-based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]  
    Number of RSU's   Weighted-Average Grant Date Fair Value
         
Outstanding at January 1, 2019    
2,816
    $
64.80
 
Granted    
4,904
    $
5.90
 
Exercised and converted to common shares    
(1,127
)   $
22.20
 
Forfeited    
(1,126
)   $
22.20
 
Outstanding at December 31, 2019    
5,467
    $
29.62
 
                 
Exercisable at December 31, 2019    
2,925
    $
50.23