100000 - Document - Document And Entity Information
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100010 - Statement - Consolidated Balance Sheets
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100020 - Disclosure - Note 9 - Net Loss Per Share - Schedule of Basic and Diluted Net Loss Per Common Share (Details) 2
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100030 - Statement - Consolidated Balance Sheets (Parentheticals)
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100040 - Statement - Consolidated Statements of Cash Flows 2
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100050 - Statement - Consolidated Statements of Operations
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100060 - Statement - Consolidated Statements Convertible Preferred Stock and Stockholders' Equity
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100070 - Statement - Consolidated Statements Convertible Preferred Stock and Stockholders' Equity (Parenthetical)
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100080 - Statement - Consolidated Statements of Cash Flows
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995453 - Disclosure - Cybersecurity Risk Management, Strategy and Governance
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995463 - Disclosure - Note 1 - Organization and Business
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995473 - Disclosure - Note 2 - Summary of Significant Accounting Policies
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995483 - Disclosure - Note 3 - Balance Sheet Details
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995493 - Disclosure - Note 4 - Fair Value Measurements
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995503 - Disclosure - Note 5 - Stockholders' Equity
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995513 - Disclosure - Note 6 - Debt
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995523 - Disclosure - Note 6 - Equity Incentive Plans
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995533 - Disclosure - Note 7 - Collaborations and License Agreements
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995543 - Disclosure - Note 8 - Commitments and Contingencies
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995553 - Disclosure - Note 9 - Net Loss Per Share
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995563 - Disclosure - Note 10 - Employee Benefits
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995573 - Disclosure - Note 11 - Income Taxes
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995583 - Disclosure - Note 12 - Segment Information
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995593 - Disclosure - Note 2 - Summary of Significant Accounting Policies (Policies)
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995603 - Disclosure - Note 3 - Balance Sheet Details (Tables)
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995613 - Disclosure - Note 4 - Common Stock Warrants (Tables)
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995623 - Disclosure - Note 5 - Fair Value Measurements (Tables)
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995633 - Disclosure - Note 6 - Debt (Tables)
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995643 - Disclosure - Note 5 - Stockholders' Equity (Tables)
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995653 - Disclosure - Note 6 - Equity Incentive Plans (Tables)
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995663 - Disclosure - Note 9 - Net Loss Per Share (Tables)
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995673 - Disclosure - Note 8 - Commitments and Contingencies (Tables)
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995683 - Disclosure - Note 11 - Income Taxes (Tables)
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995693 - Disclosure - Note 12 -Segment Information (Tables)
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995703 - Disclosure - Note 1 - Organization and Business (Details)
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995713 - Disclosure - Note 2 - Summary of Significant Accounting Policies (Details Textual)
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995723 - Disclosure - Note 3 - Balance Sheet Details - Summary of Prepaid Expenses and Other Current Assets (Details)
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995733 - Disclosure - Note 3 - Balance Sheet Details - Summary of Other Noncurrent Assets (Details)
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995743 - Disclosure - Note 3 - Balance Sheet Details - Summary of Accrued Liabilities (Details)
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995753 - Disclosure - Note 4 - Fair Value Measurements (Details)
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995763 - Disclosure - Note 4 - Fair Value Measurements - Activity for Items Measured at Fair Value on a Recurring Basis (Details)
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995773 - Disclosure - Note 5 - Stockholders' Equity (Details Textual)
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995783 - Disclosure - Note 5 - Stockholders' Equity - Schedule of Stockholders' Equity warrant outstanding and exercisable (Details)
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995793 - Disclosure - Note 5 - Stockholders' Equity - Summary of Warrant Activity (Details)
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995803 - Disclosure - Note 6 - Equity Incentive Plans (Details Textual)
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995813 - Disclosure - Note 6 - Equity Incentive Plans - Schedule of Fair Value of Options Granted (Details)
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995823 - Disclosure - Note 6 - Equity Incentive Plans - Schedule of Summarized Stock Option Activity (Details)
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995833 - Disclosure - Note 6 - Equity Incentive Plans - Schedule of Stock-based Compensation for all Stock Awards (Details)
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995843 - Disclosure - Note 6 - Equity Incentive Plans - Schedule of Restricted Stock Units Activity (Details)
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995853 - Disclosure - Note 7 - Collaborations and License Agreements (Details Textual)
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995863 - Disclosure - Note 8 - Commitments and Contingencies (Details Textual)
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995873 - Disclosure - Note 8 - Commitments and Contingencies - Accrued liabilities in the consolidated balance sheet (Details)
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995883 - Disclosure - Note 9 - Net Loss Per Share - (Details Textual)
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995893 - Disclosure - Note 9 - Net Loss Per Share - Schedule of Basic and Diluted Net Loss Per Common Share (Details)
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995903 - Disclosure - Note 9 - Net Loss Per Share - Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share (Details)
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995913 - Disclosure - Note 11 - Income Taxes (Details Textual)
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995923 - Disclosure - Note 11 - Income Taxes - Schedule of Statutory Federal Income Tax Applied to Loss Before Income Tax (Details)
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995933 - Disclosure - Note 11 - Income Taxes - Schedule of Deferred Income Tax Assets and Liabilities (Details)
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995943 - Disclosure - Note 12 - Segment Information (Details Textual)
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995953 - Disclosure - Note 12 - Segment Information - Schedule of Reconciliation of Loss from Operations Disclosure Disclosure (Details)
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Statement [Line Items]
Statement [Line Items]
Debt Instrument [Axis]
Cybersecurity Risk Board of Directors Oversight [Text Block]
Plan Name [Domain]
Joint development expenses.
Joint Development Expenses
Joint development expenses
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
Statutory federal income tax rate of 21 percent applied to loss before income taxes
Share based compensation expense
Deferred Compensation Arrangement with Individual, Allocated Share-Based Compensation Expense
Increase (Decrease) in Other Operating Assets and Liabilities, Net, Total
Increase (Decrease) in Other Operating Assets and Liabilities, Net
Other
Changes in fair value of contingent consideration
Changes In Fair Value Of Contingent Consideration
Changes in fair value of contingent consideration.
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
Schedule of Stockholders' Equity Note, Warrants or Rights
Entity Address, Postal Zip Code
Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block]
Entity Incorporation, State or Country Code
Closing period of merger agreement
Closing period of merger agreement.
Closing Period of Merger Agreement
Incremental fair value of modified warrants (Note 5)
Incremental Fair Value of Modified or Exchanged Warrants
Incremental fair value of modified or exchanged warrants.
Interest paid
Interest Paid, Excluding Capitalized Interest, Operating Activities
Interest Paid, Excluding Capitalized Interest, Operating Activities
Repriced Warrants [Member]
Repriced warrants.
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Unrecognized compensation cost related to outstanding RSUs
Number of operating segments
Number of Operating Segments
Share-Based Payment Arrangement, Tranche One [Member]
Tranche One [Member]
It represents the amount of stock issued during period value of common stock upon warrant exercises.
Stock Issued During Period Value Of Common Stock Upon Warrant Exercises
Issuance of common stock upon warrant exercises
Options Exercisable, Weighted Average Exercise Price (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Stockholders' Equity, Reverse Stock Split
Reverse stock split
Balance (in shares)
Balance (in shares)
Shares, Outstanding
Shares Outstanding
Auditor Name
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Program Expenses
Program expenses.
Program expenses
Recurring fair value measurements of liabilities
Recurring fair value measurements of liabilities
Recurring fair value measurements of liabilities.
Represents information regarding Series A convertible preferred stock.
Series A Convertible Preferred Stock [Member]
Series A Convertible Preferred Stock [Member]
Retained earnings accumulated income.
Retained Earnings Accumulated Income (Deficit)
Accumulated deficit
Deferred tax assets accrued expenses
Deferred Tax Assets Accrued Expenses
Accrued expenses
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies
Unregistered Shares.
Unregistered Shares [Member]
Unregistered Shares [Member]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
Schedule of Fair Value of Options Granted
Product and Service [Axis]
Derivative Financial Instruments
Derivatives, Policy [Policy Text Block]
CVR Agreement, distribution minimum amount
CVR agreement, distribution minimum amount
CVR Agreement, Distribution Minimum Amount
Adjustments To Additional Paid In Capital Warrant Issued Shares
Adjustments to additional paid in capital warrant issued, shares.
Issuance of common stock warrants related to promissory note (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage
Award Vesting Rights Percentage
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Supplemental disclosures of non-cash investing and financing activities:
Noncash Investing and Financing Items [Abstract]
Cybersecurity Risk Management Processes Integrated [Text Block]
Equity [Text Block]
Stockholders' Equity
Class of Warrant or Right [Axis]
Sale of Stock [Domain]
Cash and Cash Equivalents [Domain]
Remaining balance under insurance financing arrangements
Line of Credit Facility, Remaining Borrowing Capacity
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Entity Central Index Key
CIK
Warrant [Member]
Warrants for common stock
Warrant [Member]
May 2024 Placement Agent Warrants [Member]
May 2024 Placement Agent Warrants.
Restructuring Reserve [Roll Forward]
Number of Options, Forfeited, expired or cancelled (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Number of Options, Forfeited, expired or cancelled (in shares)
Auditor Opinion
Auditor Opinion [Text Block]
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Fair value of warrants issued to representatives of underwriter
Fair Value of Warrants Issued to Representatives of Underwriter
Fair value of warrants issued to representatives of underwriter.
Common Stock, Shares, Issued, Total
Common Stock, Shares, Issued
Common stock, shares issued (in shares)
Fair Value Measurement Inputs and Valuation Techniques [Table]
Increase (Decrease) in Prepaid Expense and Other Assets, Total
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid and other current assets and other noncurrent assets
The 2021 ESPP member
The 2021 ESPP [Member]
Remaining lease term
Lessee, Operating Lease, Remaining Lease Term
Preferred Stock [Member]
Preferred Stock [Member]
Income Statement [Abstract]
April 2023 Warrants [Member]
April two thousand twenty three warrants.
April Two Thousand Twenty Three Warrants [Member]
Entity Address, State or Province
Issuance of common stock for employee stock purchase plan
Stock Issued During Period, Value, Employee Stock Purchase Plan
Maximum shares issued under ESPP
Accrued clinical trial costs
Represents the amount of accrued clinical trial costs as of the balance sheet date.
Accrued clinical trial expenses
Deferred tax assets depreciation.
Deferred Tax Assets Depreciation
Depreciation
Options Exercisable, Aggregate Intrinsic Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Cover [Abstract]
Cover
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Amount
Stock-based compensation
Cash and Cash Equivalents
Cash and Cash Equivalents, Unrestricted Cash and Cash Equivalents, Policy [Policy Text Block]
Comprehensive Income, Policy [Policy Text Block]
Comprehensive Loss
Basic
Earnings Per Share, Basic, Total
Earnings Per Share, Basic
Basic net loss per common share
Increase of valuation allowance
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
uncertain income tax positions
Uncertain Income Tax Positions
Uncertain income tax positions
Senior Secured Promissory Note Warrants, First Closing [Member]
Represents information regarding warrants associated with the first closing of the Senior Secured Promissory Notes.
Operating expenses:
Operating Expenses [Abstract]
Document Annual Report
Consolidation Items [Domain]
Insurance Financing Arrangement [Member]
Insurance Financing Arrangement [Member]
Insurance Financing Arrangement.
Contingent value right, pro rata, net proceeds from sale or licensing
Contingent Value Right, Pro Rata, Net Proceeds from Sale or Licensing
Contingent value right, pro rata, net proceeds from sale or licensing
Share-Based Payment Arrangement, Expense
Share-based compensation expense
Out-of-pocket expenses
Out-of-pocket expenses
Out-of-Pocket Expenses
Retained Earnings (Accumulated Deficit), Total
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Ending Balance
Retained Earnings (Accumulated Deficit)
Retained earnings (Accumulated deficit), ending balance
License Agreements with the Regents of the University of California [Member]
Represents information regarding license agreements with the Regents of the University of California for exclusive commercial rights to certain patents, technology and know-how.
License Agreements with the Regents of the University of California [Member]
Plan Name [Axis]
Segment Reporting [Abstract]
Number of Options, Outstanding (in shares)
Number of Options, Outstanding (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Number of shares outstanding
Assets, Current [Abstract]
Current assets:
Common Stock capital shares reserved for future issuance (in shares)
Common Stock, Capital Shares Reserved for Future Issuance
Additional Financing Agreements Two [Member]
Represents information regarding the second additional financing agreement or second set of financing agreements.
Financing arrangement expiration period
Line of Credit Facility, Expiration Period
Deferred Tax Liabilities, Net
Net deferred taxes
Net deferred taxes
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Table Text Block]
Summary of Prepaid Expenses and Other Current Assets
Net cash used in operating activities
Net Cash Provided by (Used in) Operating Activities
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Forfeited, Weighted Average Grant Date Fair Value
Royalty Expense
Royalty expense
Product and Service [Domain]
Lessee, Operating Lease, Term of Contract
Lessee, operating lease, term of contract (Year)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Outstanding, Weighted Average Remaining Contractual Terms
Non-vested, Weighted Average Contractual Life (Years)
Weighted Average Remaining Contractual Life (Years)
Operating Loss Carryforwards, Total
Operating Loss Carryforwards
Operating loss carry forwards
Deposit Assets
Deposit Assets, Total
Deposits
Property, Plant and Equipment, Net, Total
Property, Plant and Equipment, Net, Beginning Balance
Property, Plant and Equipment, Net, Ending Balance
Property, Plant and Equipment, Net
Property and equipment, net
Percentage of net revenue
Percentage of net revenue
Percentage of net revenue
Type of Restructuring [Domain]
Vesting [Axis]
Common stock, par or stated value per share
Common Stock, Par or Stated Value Per Share
Common Stock, Par or Stated Value Per Share (in dollars per share)
Accrued Royalties, Current
Accrued royalties, current
Stock options [Member]
Cybersecurity Risk Management Positions or Committees Responsible [Text Block]
Warrant Inducement and Equity Issuance Costs Included in Accounts Payable and Accrued Liabilities
Warrant inducement and equity issuance costs included in accounts payable and accrued liabilities
Warrant inducement and equity issuance costs included in accounts payable and accrued liabilities
Warrant inducement and equity issuance costs included in accounts payable and accrued liabilities
Measurement Input Type [Domain]
Statement of Cash Flows [Abstract]
Counterparty Name [Axis]
Antidilutive Securities, Name [Domain]
Series A 4.5% Convertible Preferred Stock [Member]
Represents information pertaining to Series A 4.5% convertible preferred stock.
Schedule of Other Noncurrent Assets
Schedule of Other Assets, Noncurrent [Table Text Block]
Accrued severance and benefits
Supplemental Unemployment Benefits, Severance Benefits
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Warrants to purchase shares of Company's common stock
Warrants to purchase shares of common stock
April 2023 Offering [Member]
April Two Thousand And Twenty Three Offering [Member]
April two thousand And twenty three offering.
Restructuring costs
Restructuring Costs
Restructuring Costs, Total
Restructuring costs (Note 8)
Equity Components [Axis]
Entity Address, Address Line One
Employee-related Liabilities, Current, Total
Employee-related Liabilities, Current
Accrued compensation and benefits
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Number of Restricted Stock Units, Granted
Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block]
Financing Agreements [Member]
Represents information regard agreements to finance certain insurance policies.
Additional Financing Agreements One [Member]
Represents information pertaining to the first additional financing agreement or first set of financing agreements.
Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Amount
Change in tax rate
Contingent consideration, measurement input
Business Combination, Contingent Consideration, Liability, Measurement Input
Total other income, net
Nonoperating Income (Expense)
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk free interest rate
Non cash impact of exercise price reset on outstanding warrants related to down round provisions
Non Cash Impact of Exercise Price Reset on Outstanding Warrants Related to Down Round Provisions
Non cash impact of exercise price reset on outstanding warrants related to down round provisions
Option Contract Indexed to Equity, Settlement, Number of Shares
Option to purchase shares of Company's common stock
The December 2019 Note [Member]
Represents information regarding an unsecured promissory note to a consultant as payment for consulting services performed in 2019.
Revenue Recognition, Software [Policy Text Block]
License Revenue
Contingent Consideration Obligations [Member]
Contingent consideration obligations.
Contingent Consideration Obligations [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number, Beginning Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number, Ending Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Number of Restricted Stock Units, Non-vested
Granted, Weighted Average Grant Date Fair Value
Entity Voluntary Filers
Entity Voluntary Filers
Amendment Flag
Amendment
Operating Loss Carryforwards [Table]
Prepaid software licenses
Prepaid Software Licenses
Prepaid software licenses.
Operating lease liabilities
Increase (Decrease) in Operating Lease Liability
September 2023 Offering.
September 2023 Offering [Member]
September 2023 Offering [Member]
Deferred Tax Assets Lease Liability
Deferred tax assets lease liability.
Lease liability
Operating Lease, Liability, Noncurrent
Operating lease liability, net of current portion
Domestic Tax Jurisdiction [Member]
Federal [Member]
Debt Instrument, Name [Domain]
Amount of required minimum rental payments for leases having an initial or remaining non-cancelable letter-terms in excess of one year.
Operating Leases, Future Minimum Payments
Total remaining future minimum lease payments
Reconciliation of Operating Profit (Loss) from Segments to Consolidated [Table Text Block]
Schedule of Reconciliation of Loss from Operations
May two thousand twenty two warrants [Member]
May Two Thousand Twenty Two Warrants [Member]
May 2022 Warrants [Member]
Sale of Stock, Price Per Share
Shares Sold, Price Per Share
The 2021 Plan [Member]
Represents information regarding the 2021 Equity Incentive Plan.
The 2021 EIP and Inducement Plan [Member]
Net loss
Net loss
February 2024 Warrant Inducement Replacement Common Stock Warrants [Member]
February 2024 warrant inducement replacement common stock warrants.
Lessee, Lease, Description [Table]
Number of Options, Exercised (in shares)
Warrants exercised
Options Exercised (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Number of Options, Exercisable (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Research and Development Expense [Member]
Research and Development Expense [Member]
Core research and development operating expenses [Member]
Schedule of Debt [Table Text Block]
Gain (Loss) on Disposition of Property Plant Equipment, Excluding Oil and Gas Property and Timber Property
Loss on disposal of property and equipment
Equity Component [Domain]
Statistical Measurement [Domain]
Document Financial Statement Error Correction [Flag]
December 2024 Offering PreFunded Common Stock Warrants [Member]
December 2024 offering prefunded common Stock warrants.
General and administrative
General and Administrative Expense, Total
General and Administrative Expense
General and administrative expenses
NSI-532.IGF-1 [Member]
NSI-532.IGF-1 [Member]
NSI-532.IGF-1.
Clinical Trial Expenses
Clinical Trial Expenses, Policy [Policy Text Block]
Disclosure of accounting policy for clinical trial expenses.
Balance Sheet Details
Supplemental Balance Sheet Disclosures [Text Block]
Business Combination, Contingent Consideration, Liability, Noncurrent
Contingent consideration obligation
Contingent consideration obligation, net of current portion
Other Nonoperating Income (Expense), Total
Other Nonoperating Income (Expense)
Other income, net
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Text Block]
Deferred equity issuance costs.
Deferred Equity Issuance Costs
Deferred equity issuance costs againist additional paid-in capital
PALI Two One Zero Eight [Member]
PALI-2108.
PALI-2108 [Member]
Cybersecurity Risk Management Processes Integrated [Flag]
Reconciliation of cash, cash equivalents and restricted cash to the balance sheets:
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents [Abstract]
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Meals and Entertainment, Amount
Meals and entertainment
Loss on issuance of warrants
FinancingCostDerivativeWarrantLiabilities
Represents amount recognized during the period for the financing cost associated with derivative warrant liabilities.
Loss on issuance of warrants
Reduction in work force
Percentage Of Reduction In Work Force
Percentage of reduction in work force
Preferred Stock, Shares Issued
Preferred Stock, Shares Issued
Preferred stock, shares issued (in shares)
Retirement Benefits [Text Block]
Employee Benefits
Lessee discount rate
Lessee, Operating Lease, Discount Rate
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Nonvested, Number of Shares, Beginning Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Nonvested, Number of Shares, Ending Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Nonvested, Number of Shares
Number of shares unvested and outstanding
Adjustments to Additional Paid in Capital, Warrant Issued
Issuance of common stock warrants related to promissory note
Deferred tax liabilities right-of-use asset
Deferred Tax Liabilities Right-of-Use Asset
Operating right-of-use asset
Issuance of common stock for employee stock purchase plan (shares)
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Shares issued under the ESPP
Consolidation Items [Axis]
Deferred equity issuance costs
Debt Issuance Costs, Current, Net, Total
Debt Issuance Costs, Current, Net
Operating lease expense
Operating Lease, Expense
Prepaid expenses and other current assets
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Options Forfeited, expired or cancelled, Weighted Average Exercise Price (in dollars per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Restricted cash
Restricted Cash, Noncurrent
Restricted cash, Total
Restricted cash, noncurrent
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Class of Stock [Domain]
Common stock, shares outstanding (in shares)
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding, Ending Balance
Common Stock, Shares, Outstanding
Fair Value of Financial Instruments
Fair Value Measurement, Policy [Policy Text Block]
Restructuring Reserve, Accrual Adjustment
Net accrual additions
Preferred Stock, Par or Stated Value Per Share (in dollars per share)
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value (in dollars per share)
Capitalized research and development costs
Deferred Tax Asset, In-Process Research and Development
Income Tax Reconciliation Nondeductible Expense Warrants
Income Tax Reconciliation Nondeductible Expense Warrants
Warrants
Antidilutive Securities [Axis]
Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block]
Schedule of Weighted Average Number of Shares [Table Text Block]
Schedule of Weighted Average Number of Shares
Schedule of Basic and Diluted Net Loss Per Common Share
Effective Income Tax Rate Reconciliation, Other Adjustments, Amount
Others
Entity Interactive Data Current
Income Tax Reconciliation Nondeductible Expense Expiration of Tax Attributes
Expiration of tax attributes
Expiration of tax attributes
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Vested, Weighted Average Grant Date Fair Value
Statistical Measurement [Axis]
February 2024 Warrant Inducement [Member]
February 2024 warrant inducement.
February 2024 Warrant Inducement [Member]
Schedule of Maturities of the Company's operating lease liabilities
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Share-Based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block]
Schedule of Restricted Stock Units Activity
Paycheck Protection Program, CARES Act [Member]
Represents loan designed to provide funds for small businesses to keep their employees on the payroll.
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Granted, Weighted Average Grant Date Fair Value
Unrecognized compensation cost weighted-average period of recognition
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Accrued accounts payable
Accrued accounts payable
Represents the amount of accrued accounts payable, included in accrued liabilities rather than in the Accounts Payable line item.
Deferred Tax Assets, Net
Net deferred tax asset
Net deferred tax asset
Research and Development Expense, Policy [Policy Text Block]
Research and Development Expenses
Statement of Income Location, Balance [Axis]
Cash and Cash Equivalents [Axis]
Total assets
Assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected contractual life
Restructuring Type [Axis]
Deferred equity issuance costs recognized as a reduction in additional paid-in capital from financing activities
Deferred Equity Issuance Costs Recognized As a Reduction in Additional Paid in Capital From Financing Activities
Deferred Equity Issuance Costs Recognized As a Reduction in Additional Paid in Capital From Financing Activities
Deferred Tax Liabilities, Gross
Total deferred tax liabilities
Total deferred tax liabilities
Total deferred tax liabilities
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Number of Restricted Stock Units, Vested
Number of Stock Units, Vested
Number of Restricted Stock Units, Vested
Noncash operating lease expense
Noncash operating lease expense
Non-cash operating lease expense
New Accounting Pronouncements, Policy [Policy Text Block]
Recently Adopted Accounting Pronouncements
Entity Address, City or Town
Business Combination, Separately Recognized Transactions, Additional Disclosures, Acquisition Costs
Transaction related costs
Auditor Location
Payments of Stock Issuance Costs
Proceeds from issuance of debt
Payment of equity issuance costs
Cost inquired with exercise of warrants
Payment of equity issuance costs
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag]
Number of Restricted Stock Units, Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Number of shares forfeited
Number of Restricted Stock Units, Forfeited
August 2024 Offering Series 2 Common Stock Warrants [Member]
August 2024 offering series 2 common stock warrants.
Payments for Restructuring
Cash paid
Cash paid
Number of shares issued during the period common stock upon warrant exercises.
Stock Issued During Period Shares Of Common Stock Upon Warrant Exercises
Issuance of common stock upon warrant exercises (in shares)
Bridge, January 2021, and July 2021 Common Stock Warrants [Member]
Bridge, January 2021, and July 2021 common stock warrants.
Series Two Warrants [Member]
Series 2 Warrants [Member]
Series 2 Warrants [Member]
Warrant liability
Derivative Liability, Noncurrent
Derivative liability, noncurrent
Depreciation, Total
Depreciation
Depreciation
Deferred Equity Issuance Costs
Deferred Charges, Policy [Policy Text Block]
Schedule of Segment Reporting Information, by Segment [Table]
Cybersecurity Risk Third Party Oversight and Identification Processes [Flag]
Corpotate Office [Member]
Office Space Lease for Corporate Headquarters in Carlsbad, CA [Member]
Office Space Lease for Corporate Headquarters in Carlsbad, CA [Member]
Represents information regarding an office space lease for corporate headquarters in Carlsbad, CA.
Private Placement [Member]
Private Placement [Member]
Equity Incentive Plans
Share-Based Payment Arrangement [Text Block]
Cybersecurity Risk Management Positions or Committees Responsible Report to Board [Flag]
Warrants outstanding, weighted average remaining contratual life (years)
Warrants outstanding, December 31, 2020 (Year)
Represents the weighted average remaining contractual life of warrants or rights outstanding.
Series A Preferred Stock [Member]
Series A Preferred Stock [Member]
Replacement warrants.
Replacement Warrants [Member]
Replacement Warrants [Member]
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]
Fair Value Disclosures [Abstract]
Class of warrant or right forfeited expired or cancelled during period weighted average exercise price.
Class of Warrant or Right Forfeited Expired or Cancelled During Period Weighted Average Exercise Price
Forfeited, expired, or cancelled, weighted average exercise price
Entity Public Float
Warrant Inducement Agreements [Member]
Warrant Inducement Agreements [Member]
Warrant Inducement Agreements [Member]
Liabilities, Current [Abstract]
Current liabilities:
Lease Contractual Term [Axis]
Issuance of Stock and Warrants for Services or Claims
Issuance of common stock to vendors
Accrued Joint Development Expenses
Accrued Joint Development Expenses
Accrued joint development expenses
Document Type
Document Type
Number of Terminated License Agreements
Number of Terminated License Agreements
Number of terminated license agreements
Title of 12(b) Security
Cash and Cash Equivalents, at Carrying Value, Total
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Cash and Cash Equivalents, at Carrying Value
Cash and cash equivalents, at carrying value, ending balance
Milestone payments.
Milestone Payments
Milestone payments
Class of warrant or right issued during period weighted average remaining contractual life.
Class of Warrant or Right Issued During Period Weighted Average Remaining Contractual Life
Granted, weighted average remaining contractual life
Cybersecurity Risk Management, Strategy, and Governance [Line Items]
Statement of Stockholders' Equity [Abstract]
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value
Balance, Beginning
Balance, Ending
Document Fiscal Period Focus
Shares withheld for payment of employee withholding tax liability
Payment, Tax Withholding, Share-Based Payment Arrangement
Number of options, Granted (in shares)
Number of Options, Granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Restricted cash
Restricted Cash and Cash Equivalents, Total
Restricted Cash and Cash Equivalents
Preferred Stock, Dividend Rate, Percentage
Preferred Stock, Dividend Rate, Percentage
Adjustment to record the impact of exercise price reset on outstanding warrants related to down round provisions diluted
Adjustment to record the impact of exercise price reset on outstanding warrants related to down round provisions
Warrant, Down Round Feature, Increase (Decrease) in Equity, Amount
Leases
Lessee, Leases [Policy Text Block]
Schedule of Fair Value of Options Granted
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Operating Segments [Member]
Operating Segments [Member]
Other non-deductible expenses
Income Tax Reconciliation Other Non-Deductible Expenses
Other non-deductible expenses
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount
State taxes - net of federal benefit
Class of Warrant or Right, Exercise Price of Warrants or Rights
Warrants exercise price of common stock warrants
Warrants exercise price of common stock Warrants
Weighted average exercise price
Financial Instruments [Domain]
Placement Agent, Solicitor and Representative Common Stock Warrants [Member]
Placement agent, solicitor and representative common stock warrants.
Sale of Stock [Axis]
Cash flows from investing activities:
Net Cash Provided by (Used in) Investing Activities [Abstract]
Earnings Per Share, Basic, by Common Class, Including Two Class Method [Line Items]
Revenue from Contract with Customer, Excluding Assessed Tax
License revenue
Income Taxes
Income Tax Disclosure [Text Block]
Schedule of Statutory Federal Income Tax Rate Applied to Loss Before Income Tax
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Cybersecurity Risk Management, Strategy, and Governance [Abstract]
Placement Agent Warrants [Member]
Placement Agent Warrants [Member]
Placement agent warrants.
Notes To Financial Statements [Abstract]
Notes To Financial Statements Abstract
Underwriting Commitments Per Share
Underwriting agreement, per share
Underwriting commitments, per share
Credit Facility [Domain]
pali_RoyaltyRatePortionOfSublicenseIncomeToBePaidPercentageOfOneThirdOfUpfrontPaymentAndMilestonePaymentReceived
Represents the royalty rate on the portion of sublicense income to be paid, expressed as a percentage of one-third of the upfront payment and milestone payment received.
Royalty rate, portion of sublicense income to be paid, percentage of one-third of upfront payment and milestone payment received
May 2024 Offering [Member]
May 2024 Offering [Member]
May 2024 Offering.
Other Accrued Liabilities, Current
Accrued other
Document Period End Date
Period End Date
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Prepaid Expense and Other Assets [Abstract]
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Anti-dilutive securities (in shares)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Restructuring Reserve, Total
Restructuring Reserve
Balance as of the beginning of year
Balance as of the end of year
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Stock-based compensation expense and related charges
Accrued Liabilities, Current
Accrued liabilities
Accrued Liabilities, current, Total
December 2024 Offering Common Stock Warrants [Member]
December 2024 offering common stock warrants.
Other Research and Development Expense
Other research and development expenses
Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description
Defined Benefit Plan, Plan Assets, Administration Expense
Total expenses
December 2024 Offering [Member]
December 2024 Offering.
December 2024 Offering [Member]
Income Tax Expense (Benefit)
Income tax expense
Trading Symbol
Total stockholders' equity
Balance
Balance
Equity, Attributable to Parent
Deferred Tax Assets, Gross
Total deferred tax assets
Total deferred tax assets
Common stock warrants
Class of Warrant or Right, Outstanding
Number of warrants outstanding
Stock-Based Compensation
Share-Based Payment Arrangement [Policy Text Block]
Derivative Instrument [Axis]
Restricted Stock Units (RSUs) [Member]
Restricted Stock Units [Member]
Sale of stock during period
Sale of Stock, Number of Shares Issued in Transaction
Cybersecurity Risk Management, Strategy, and Governance [Table]
Initial fair value at the original issuance date
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Issuances
DELAWARE
Delaware [Member]
Cybersecurity Risk Management Expertise of Management Responsible [Text Block]
Schedule of Stock-based Compensation for all Stock Awards
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Accrued Liabilities [Member]
Accrued Liabilities [Member]
Measurement Input, Discount Rate [Member]
Discount Rate [Member]
Change in fair value during the period
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Earnings
Measurement Input Type [Axis]
January 2023 Warrants [Member]
January Two Thousand Twenty Three Warrants.
January Two Thousand Twenty Three Warrants [Member]
Geographical [Axis]
Unrecognized compensation cost related to outstanding options
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Maximum Aggregate Consideration
Maximum aggregate consideration.
Maximum Aggregate Consideration
Restructuring and Related Costs [Table Text Block]
Schedule of Accrued liabilities in the consolidated balance sheet
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
pali_NumberOfLicenseAgreements
Represents the number of license agreements in place.
Number of license agreements
Accrued Insurance, Current
Insurance financing debt
Security Exchange Name
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Weighted Average Risk Free Interest Rate
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Weighted Average Risk Free Interest Rate
Weighted-average risk-free interest rate
Counterparty Name [Domain]
Operating Loss Carryforwards [Line Items]
Senior Secured Promissory Notes [Member]
Represents information regarding the Senior Secured Promissory Notes.
Total operating expenses
Operating Expenses
Total operating expenses
Issuance of common stock to vendor
Stock Issued During Period, Value, Issued for Services
Class of Stock [Axis]
Cost Reduction Plan [Member]
Cost Reduction Plan [Member]
cost reduction plan Member.
Fair Value Disclosures [Text Block]
Fair Value Measurements
Weighted-average grant date fair value of options granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Percentage of gross proceeds
Percentage of gross proceeds
Percentage of Gross Proceeds
Maximum [Member]
Maximum [Member]
Payment of warrant inducement issuance costs
Payment of Warrant Inducement Issuance Costs
Payment of warrant inducement issuance costs.
Total liabilities and stockholders' equity
Liabilities and Equity
Operating Lease, Right-of-Use Asset
Operating Lease, Right-of-Use Asset
Operating lease right-of-use asset
Supplemental disclosures of cash flow information:
Supplemental Cash Flow Information [Abstract]
Fair Value of Warrants Issued to Solicitation Agent
Fair value of warrants issued to solicitation agent
Fair value of warrants issued to solicitation agent
Retirement Benefits [Abstract]
Diluted
Earnings Per Share, Diluted, Total
Earnings Per Share, Diluted
Diluted net loss per common share
Reverse stock split fractional share settlement
Stock Issued During Period, Shares, Reverse Stock Splits
Total liabilities
Liabilities
April 2023 Offering [Member]
April 2023 Offering.
April 2023 Offering [Member]
Total current assets
Assets, Current
Net cash used in investing activities
Net Cash Provided by (Used in) Investing Activities
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Weighted Average Volatility Rate
Weighted-average volatility
Summary Of Significant Accounting Policies [Line Items]
Summary Of Significant Accounting Policies [Line Items]
Summary Of Significant Accounting Policies [Line Items]
Consecutive trading day period
Number Of Trading Days
Number Of Trading Days
Stock Issued During Period, Shares, New Issues (in shares)
Offering shares (Per share)
Issuance of stock during period, Shares
Entity Filer Category
Senior Secured Promissory Note Warrants, Second Closing [Member]
Represents information regarding warrants associated with the second closing of the Senior Secured Promissory Notes.
Prepaid insurance, less current portion
Prepaid Expense, Noncurrent
Prepaid Expense, Noncurrent, Total
Net Income (Loss) Available to Common Stockholders, Diluted
Net loss attributable to common shares - diluted
Net loss attributable to common shares - diluted
Organization and Business
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Nonoperating Income (Expense) [Abstract]
Other (expense) income:
Current Fiscal Year End Date
Imputed interest
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less: imputed interest
Less: imputed interest
Repayments of Short-term Debt, Total
Repayments of Short-Term Debt
Payments on insurance financing debt
Share-based Payment Arrangement, Noncash Expense, Total
Share-Based Payment Arrangement, Noncash Expense
Stock-based compensation and related charges
Stock-based compensation
Options Outstanding, Aggregate Intrinsic Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
2021 Inducement plan [Member]
2021 Inducement Plan [Member]
2021 Inducement Plan [Member]
Current portion of contingent consideration obligation
Business Combination, Contingent Consideration, Liability, Current
Net proceeds from insurance financing debt included in prepaid and other assets and other noncurrent assets.
Net Proceeds from Insurance Financing Debt Included in Prepaid and Other Assets and Oher Noncurrent Assets
Insurance financing debt included in prepaid and other current assets and other noncurrent assets
Entity Registrant Name
Registrant Name
Stock Purchase Warrants [Member]
Represents information pertaining to stock purchase warrants.
Warrant Liabilities [Member]
Exercised (in shares)
pali_ClassOfWarrantOrRightExercisedDuringPeriod
The number of warrants or rights exercised during period.
Number of Reportable Segments
Number of reportable segments
Net Proceeds
Net Proceeds
Net Proceeds from the exercise of warrants
Net Loss Per Share
Earnings Per Share [Text Block]
Entity Emerging Growth Company
Net Income (Loss) Available to Common Stockholders, Basic [Abstract]
Basic and diluted net loss per common share:
Money Market Funds [Member]
Money Market Funds [Member]
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted Average Number of Shares Outstanding, Basic
Weighted average shares used in calculating basic loss per share
Basic weighted average shares used in computing net loss per common share
Weighted average shares used in calculating basic loss per common share
Vesting [Domain]
Loss Contingencies [Line Items]
Earnings Per Share, Basic, by Common Class, Including Two-Class Method [Table]
Warrants Issuance Costs
Warrants issuance costs
Total equity issuance costs
Common Stock, Shares Authorized (in shares)
Common Stock, Shares Authorized
Proceeds from issuance of common stock
Proceeds from issuance of common stock and warrants
Proceeds from Issuance of Common Stock
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value, Vested
Grant date fair value of the options vested
Accounts payable and accrued liabilities
Increase (Decrease) in Accounts Payable and Accrued Liabilities, Total
Increase (Decrease) in Accounts Payable and Accrued Liabilities
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Weighted Average Expected Dividend
Weighted-average expected dividend yield
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Documents Incorporated by Reference [Text Block]
Documents Incorporated by Reference
Restricted Stock, Value, Shares Issued Net of Tax Withholdings
Issuance of common stock for vesting of restricted stock units, net of employee withholding tax liability
Options Granted, Weighted Average Exercise Price (in dollars per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Financial Instrument [Axis]
Options Outstanding, Weighted Average Remaining Contractual Life (Year)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
2013 Plan [Member]
The 2013 Plan [Member]
The 2013 Plan [Member]
Collaborations and license agreements upfront fee.
Collaborations and License Agreements Upfront Fee
Collaborations and license agreements upfront fee
General and Administrative Expense [Member]
General and Administrative Expense [Member]
Grant date fair value.
Grant Date Fair Value
Grant date fair value
October 2020 Note [Member]
October 2020 Note [Member]
Represents information regarding an unsecured promissory note issued in October 2020.
Convertible Preferred Stock, Issuable Upon Conversion of All Shares (in shares)
pali_ConvertiblePreferredStockIssuableUponConversionOfAllShares
Number of shares issuable for all shares of a given class of convertible preferred stock that may be converted.
Accrued C M C Expenses
Represents the amount of accrued CMC expenses as of the balance sheet date.
Accrued chemistry, manufacturing and controls ("CMC") expenses
Warrants for additional gross cash proceeds
Proceeds from Issuance of Warrants
Gross proceeds from the exercise of warrants
Cybersecurity Risk Role of Management [Text Block]
Accounting Policies [Abstract]
Series C Preferred Stock [Member]
Series C Preferred Stock [Member]
Schedule of Summarized Stock Option Activity
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Table Text Block [Abstract]
Income Tax Disclosure [Abstract]
Equity, Attributable to Parent [Abstract]
Stockholders' equity:
Restricted Cash
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Statement [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Requisite Service Period
Service period
Options Vested and expected to vest, Weighted Average Remaining Contractual Life (Year)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Pre Funded Warrants [Member]
Pre Funded Warrants [Member]
Pre funded warrants.
Preferred Stock, Shares Authorized
Preferred stock, shares authorized (in shares)
Fair Value Adjustment of Warrants
Incremental fair value of Warrants
License Revenue
Revenue from Contract with Customer, Including Assessed Tax
Entity File Number
Segment Reporting Disclosure [Text Block]
Segment Information
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Net (decrease) increase in cash, cash equivalents and restricted cash
Loss per common share:
Earnings Per Share [Abstract]
Date of issuance of warrant
Warrants and Rights Outstanding, Term (Year)
Warrants and Rights Outstanding, Term
Altium Growth Fund, LP [Member]
Altium Growth Fund, LP [Member]
Represents information regarding Altium Growth Fund, LP (the "Investor").
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Stock compensation
Lease Contractual Term [Domain]
Statement of Financial Position [Abstract]
Interest expense
Interest expense
Interest Expense, Total
Interest Expense, Operating and Nonoperating
Time Based Restricted Stock Units [Member]
Time based restricted stock units.
Time-based RSU [Member]
Loss from operations
Operating Income (Loss)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Expected stock price volatility
Other noncurrent assets
Other Noncurrent Assets
Sum of the carrying amounts as of the balance sheet date of other noncurrent assets.
Entity Shell Company
Entity Tax Identification Number
July 2020 Note [Member]
Represents information regarding an unsecured promissory note issued in July 2020.
Class of Warrant or Right [Domain]
License Agreements [Text Block]
The entire disclosure for license agreements.
Collaborations and License Agreements
Entity Current Reporting Status
Net loss attributable to common shares - basic
Reduction in income available to common shareholders
Net Income (Loss) Available to Common Stockholders, Basic
Net loss available to common stockholders - basic
Options Exercisable, Weighted Average Remaining Contractual Life (Year)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Financing arrangement interest rate
Line of Credit Facility, Interest Rate During Period
Geographical [Domain]
Document Fiscal Year Focus
Original Financing Agreements [Member]
Represents information regarding the original financing agreements.
Other general and administrative expenses
Other General and Administrative Expense
Tranche Two [Member]
Share-Based Payment Arrangement, Tranche Two [Member]
Preferred Stock, Value, Issued, Total
Preferred Stock, Value, Issued, Beginning Balance
Preferred Stock, Value, Issued, Ending Balance
Preferred Stock, Value, Issued
Series A Convertible Preferred Stock, $0.01 par value, 7,000,000 shares authorized; 200,000 issued and outstanding at December 31, 2024 and December 31, 2023
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Weighted-average expected term
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Weighted-average expected term
Weighted-average expected term (years)
Total cash, cash equivalents and restricted cash
Total cash, cash equivalents and restricted cash
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Cash, cash equivalents and restricted cash, beginning of year
Cash, cash equivalents and restricted cash, end of period
City Area Code
Total current liabilities
Liabilities, Current
Derivative Contract [Domain]
Legacy [Member]
Legacy.
Legacy [Member]
Local Phone Number
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding, Ending Balance
Preferred Stock, Shares Outstanding
Preferred stock, shares outstanding (in shares)
Additional Paid in Capital, Total
Additional Paid in Capital, Beginning Balance
Additional Paid in Capital, Ending Balance
Additional Paid in Capital
Additional paid-in capital
Cash transaction-related expenses And placement agent fees
Cash transaction-related expenses And placement agent fees
Cash transaction-related expenses And placement agent fees.
Restricted Stock, Shares Issued Net of Shares for Tax Withholdings
Issuance of common stock for vesting of restricted stock units, net of employee withholding tax liability (in shares)
Fair Value Measurement Inputs and Valuation Techniques [Abstract]
Notes to Financial Statements
Disclosure Text Block [Abstract]
Income Tax Jurisdiction [Axis]
Proceeds (payments) from the redemption of warrants
Proceeds from Warrant Exercises
Proceeds from the exercise of warrants
Income Taxes
Income Tax, Policy [Policy Text Block]
Deferred equity issuance costs
Deferred Costs, Current
Deferred Costs, Current, Total
Commitments and Contingencies Disclosure [Abstract]
December 2024 Representative Warrants [Member]
December 2024 Representative Warrants.
Granted, weighted average exercise price (in dollars per share)
Weighted average exercise price per share of warrants or rights issued during period.
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Schedule of Deferred Income Tax Assets and Liabilities
May Two Thousand Twenty Four Offering [Member]
May Two Thousand Twenty Four Offering.
May 2024 Offering [Member]
Operating Lease, Liability, Current
Less: current portion of lease liability
Current portion of operating lease liability
Series 1 Preferred Stock of LBS [Member]
Represents information regarding Series 1 Preferred Stock of LBS.
Warrants outstanding, weighted average exercise price (in dollars per share)
Represents the weighted average exercise price of warrants or rights outstanding.
Deferred Tax Liabilities, Prepaid Expenses
Prepaid expense
Prepaid expense
Sublicense Fees
Sublicense fees
Sublicense fees
Income Tax Jurisdiction [Domain]
Convertible Preferred Stock, Shares Issued upon Conversion
Convertible Preferred Stock issued and outstanding
Retained Earnings [Member]
Retained Earnings [Member]
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment, Total
Payments to Acquire Property, Plant, and Equipment
Reverse stock split, policy [Policy Text Block].
Reverse Stock Split
Reverse Stock Split, Policy [Policy Text Block]
Document Transition Report
Fair Value of Warrants Issued to Placement Agents
Fair value of warrants Issued to placement agents
Fair value of warrants issued to placement agents
Share-Based Compensation Arrangement by Share-Based Payment Award, Purchase Price of Common Stock, Percent
Percentage of purchase price of common stock
Accrued director stipends
Accrued director stipends
Represents the amount of accrued director stipends as of the balance sheet date.
Cost Reduction Plan Twenty Twenty Three [Member]
Cost Reduction Plan Twenty Twenty Three [Member]
2023 RIF [Member]
Proceeds from Stock Plans
Proceeds from issuance of common stock under Employee Stock Purchase Plan
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Weighted-average exercise price per share
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Concentration of Credit Risk
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Auditor Firm ID
Minimum [Member]
Minimum [Member]
Earnings Per Share Reconciliation [Abstract]
Common Stock [Member]
Common Stock [Member]
Options Vested and expected to vest, Aggregate Intrinsic Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Forfeited, expired or cancelled (in shares)
pali_ClassOfWarrantOrRightForfeitedExpiredOrCancelledDuringPeriod
The number of warrants or rights forfeited, expired or cancelled during period.
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value, Beginning Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value, Ending Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Non-vested, Weighted Average Grant Date Fair Value
Exercise price
Additional Paid-in Capital [Member]
Additional Paid-in Capital [Member]
Entity Well-known Seasoned Issuer
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Schedule of Warrant Outstanding And Exercisable [Table Text Block]
Tabular disclosure of warrants outstanding and exercisable.
Schedule of Stockholders' Equity warrant outstanding and exercisable.
Statement of Income Location, Balance [Domain]
Prepaid subscriptions and fees
Prepaid Subscriptions and Fees
Prepaid subscriptions and fees.
Other noncurrent assets
Other Assets, Noncurrent
Other noncurrent assets, Total
Net proceeds from issuance of warrants
Net proceeds from issuance of warrants
Net proceeds from exercise of warrants
Prepaid other
Other Prepaid Expense, Current
Performance Based Stock Units [Member]
Performance Shares [Member]
Class B Units [Member]
Class B Units
Entity Common Stock, Shares Outstanding
Basis of Accounting, Policy [Policy Text Block]
Basis of Presentation and Consolidation
Warrants and Rights Outstanding
Warrants and Rights Outstanding
Incremental Value of Warrants
Common Stock, Value, Issued, Total
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Ending Balance
Common Stock, Value, Issued
Common stock, $0.01 par value; 280,000,000 shares authorized; 2,768,646 and 618,056 shares issued and outstanding at December 31, 2024 and December 31, 2023, respectively
Increase (Decrease) in Employee Related Liabilities, Total
Increase (Decrease) in Employee Related Liabilities
Accrued compensation and benefits
Other receivables
Prepaid Expenses and Other Current Assets Other Receivables
Prepaid expenses and other current assets, other receivables.
Prepaid insurance
Prepaid Insurance
Disclosure of accounting policy for contingent consideration obligations.
Contingent Consideration Obligations [Policy Text Block]
Contingent Consideration Obligation
Cash and Cash Equivalents, Fair Value Disclosure
Fair Value of the company's cash and cash equivalents
Percentage cost in patent right
Percentage Cost in Patent Right
Percentage cost in patent right
Share based compensation arrangement by share based payment award fair value assumptions Cost of equity.
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Cost Of Equity
Cost of equity
Cash Consideration
Cash consideration.
Cash consideration
Schedule of Accrued Liabilities [Table Text Block]
Schedule of Accrued Liabilities
Deferred Tax Assets, Operating Loss Carryforwards, Total
Deferred Tax Assets, Operating Loss Carryforwards
Net operating loss carryforwards
Commitments and Contingencies
Commitments and contingencies (Note 8)
Weighted average shares used in calculating diluted loss per share
Weighted Average Number of Shares Outstanding, Diluted
Weighted average shares used in calculating diluted loss per share
Weighted average shares used in calculating diluted loss per common share
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Research and development
Research and development
Lessee, Operating Lease, Renewal Term
Lessee, operating lease, renewal term (Month)
Number of Options, Vested and expected to vest (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Cybersecurity Risk Management Third Party Engaged [Flag]
September Two Thousand And Twenty Three Offering [Member]
September two thousand And twenty three offering.
September 2023 Offering [Member]
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
Restructuring Reserve [Abstract]
Class of warrant or right number of rights issued.
Class of Warrant or Right Number of Rights Issued
Contingent value right issued
Weighted average shares used in computing loss per common share:
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Period of Expiration of License Agreement Description
Period of Expiration of License Agreement Description
Period of Expiration of License Agreement Description
Entity Small Business
Segment Reporting Information [Line Items]
All Other Common Stock Warrants [Member]
All other common stock warrants.
Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block]
Debt Disclosure [Text Block]
Non Cash Warrant Issuance Costs
Non cash warrant issuance costs.
Non-cash warrant issuance costs
Class of warrant or right exercised during period weighted average exercise price.
Class of Warrant or Right Exercised During Period Weighted Average Exercise Price
Exercised, weighted average exercise price
January Two Thousand And Twenty Three Offering [Member]
January two thousand And twenty three offering.
January 2023 Offering [Member]
Issuance of common stock to vendor (in shares)
Stock Issued During Period, Shares, Issued for Services
Class A Units [Member]
Class A Units
Net Income (Loss) Available to Common Stockholders, Diluted [Abstract]
Diluted net loss per common share
Percentage of Share Issued
Percentage of Share Issued
Percentage of share issued
Credit Facility [Axis]
December 2022 Warrants [Member]
December 2022 warrants
Cash flows from financing activities:
Net Cash Provided by (Used in) Financing Activities [Abstract]
Options Outstanding, Weighted Average Exercise Price (in dollars per share)
Options Outstanding, Weighted Average Exercise Price (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Weighted-average exercise price
Warrants outstanding
Warrants outstanding, balance (in shares)
Warrants outstanding, balance (in shares)
pali_ClassOfWarrantOrRightNumberOutstanding
Represents the number of warrants or rights outstanding as of the specified date.
State and Local Jurisdiction [Member]
State [Member]
Non-cash warrant modification costs
Non Cash Warrant Modification Costs
Non cash warrant modification costs.
January 2023 Offering [Member]
January 2023 Offering [Member]
January 2023 Offering [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Maximum Number of Shares Per Employee
Maximum number of shares per employee (in shares)
Deferred Tax Assets, Valuation Allowance, Total
Deferred Tax Assets, Valuation Allowance
Valuation allowance
Valuation allowance
Proceeds deposited into the CVR escrow.
Proceeds Deposited into the CVR Escrow
Proceeds deposited into the CVR escrow
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Valuation allowance
Cybersecurity Risk Management Positions or Committees Responsible [Flag]
Accounts Payable, Current, Total
Accounts Payable, Current
Accounts payable
pali_ClassOfWarrantOrRightIssuedDuringPeriod
The number of warrants or rights issued during period.
Class of warrant or right, issued during period (in shares)
Granted (in shares)