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Note 9 - Collaborations and License Agreements (Details Textual)
3 Months Ended 9 Months Ended 12 Months Ended
Sep. 30, 2022
USD ($)
Agreement
Sep. 30, 2021
USD ($)
Sep. 30, 2022
USD ($)
Agreement
Sep. 30, 2021
USD ($)
Dec. 31, 2018
USD ($)
Dec. 31, 2021
USD ($)
Collaborations and License Agreements Upfront Fee         $ 1,000,000.0  
Royalty Expense         $ 6,750,000  
Milestone Payments $ 0 $ 0 $ 0 $ 0    
License Agreements with the Regents of the University of California [Member]            
Number of License Agreements | Agreement 3   3      
Royalty Rate, Portion of Sublicense Income to Be Paid, Percentage of One-third of Upfront Payment and Milestone Payment Received 30.00%   30.00%      
Accrued Royalties, Current $ 40,000,000   $ 40,000,000     $ 81,000,000