X0306 4 2022-01-31 0000004962 AMERICAN EXPRESS CO AXP 0001357325 Seeger Laureen 200 VESEY STREET, AMERICAN EXPRESS TOWER NEW YORK NY 10285-5001 1 Chief Legal Officer Common Stock 2022-01-31 4 S 0 30808 175.5675 D 30178.236 D Common Stock 2022-01-31 4 M 0 30808 100.96 A 60986.236 D Employee Stock Option (Right to Buy) 100.96 2022-01-31 4 M 0 30808 0 D 2022-01-29 2029-01-29 Common Stock 30808 0 D The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $175.23 to $176.00. The reporting person undertakes to provide to American Express Company, any security holder of American Express Company, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within this range. The transactions reported on this Form 4 were effected pursuant to a 10b5-1 Trading Plan adopted by the reporting person on May 17, 2021. /s/ Kristina V. Fink, attorney-in-fact 2022-02-02