X0306 4 2019-05-01 0 0001501756 Adverum Biotechnologies, Inc. ADVM 0001356950 Scopa James Paul C/O ADVERUM BIOTECHNOLOGIES, INC. 1035 O'BRIEN DRIVE MENLO PARK CA 94025 1 0 0 0 Stock Option (Right to Buy) 6.48 2019-05-01 4 A 0 70000 0.00 A 2029-04-30 Common Stock 70000 70000 D 1/3 of the total number of shares subject to the option vest and become exercisable on each anniversary of May 1, 2019 (the "Vesting Commencement Date"), such that all of the shares subject to the option shall become vested and exercisable as of the third anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service with the Issuer on each such vesting date. James Paul Scopa, by /s/ Jennifer Cheng, Attorney-in-Fact 2019-05-03