<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2006-06-14</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001356949</issuerCik>
        <issuerName>Houston Wire &amp; Cable CO</issuerName>
        <issuerTradingSymbol>HWCC</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001364731</rptOwnerCik>
            <rptOwnerName>Code, Hennessy &amp; Simmons II, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>10 SOUTH WACKER DRIVE</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 3175</rptOwnerStreet2>
            <rptOwnerCity>CHICAGO</rptOwnerCity>
            <rptOwnerState>IL</rptOwnerState>
            <rptOwnerZipCode>60606</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001366105</rptOwnerCik>
            <rptOwnerName>CHS Management II, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>10 SOUTH WACKER DRIVE</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 3175</rptOwnerStreet2>
            <rptOwnerCity>CHICAGO</rptOwnerCity>
            <rptOwnerState>IL</rptOwnerState>
            <rptOwnerZipCode>60606</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001366108</rptOwnerCik>
            <rptOwnerName>Code, Hennessy &amp; Simmons, Inc.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>10 SOUTH WACKER DRIVE</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 3175</rptOwnerStreet2>
            <rptOwnerCity>CHICAGO</rptOwnerCity>
            <rptOwnerState>IL</rptOwnerState>
            <rptOwnerZipCode>60606</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>12700821</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F1"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">Code, Hennessy &amp; Simmons II, L.P. is the record holder fo these securities.  Code, Hennessy &amp; Simmons, Inc. is the general partner of CHS Management II, L.P., which in turn is the general partner of Code, Hennessy &amp; Simmons II, L.P.  Code, Hennessy &amp; Simmons Inc. and CHS Management II, L.P. may be deemed to beneficially own the securities owned by Code, Hennessy &amp; Simmons II, L.P. but disclaims beneficial ownership of securities in which it does not have a pecuniary interest.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Andrew W. Code</signatureName>
        <signatureDate>2006-06-14</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Andrew W. Code</signatureName>
        <signatureDate>2006-06-14</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Andrew W. Code</signatureName>
        <signatureDate>2006-06-14</signatureDate>
    </ownerSignature>
</ownershipDocument>
