Composition of Other Balance Sheet Items - Property and Equipment (Details) - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Property and equipment
Property and equipment, gross	$ 28,222	$ 33,409
Less accumulated depreciation and amortization	(13,049)	(16,454)
Property and equipment, net	15,173	16,955
Depreciation and amortization expense	3,000	2,600	$ 4,300
Lab equipment and furniture
Property and equipment
Property and equipment, gross	12,127	12,287
Leasehold improvements
Property and equipment
Property and equipment, gross	14,023	14,369
Software
Property and equipment
Property and equipment, gross	883	4,776
Computer equipment
Property and equipment
Property and equipment, gross	983	1,944
Construction-in-progress
Property and equipment
Property and equipment, gross	$ 206	$ 33

Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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