Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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The current period expense charged against earnings on long-lived, physical assets not used in production, and which are not intended for resale, to allocate or recognize the cost of such assets over their useful lives; or to record the reduction in book value of an intangible asset over the benefit period of such asset; or to reflect consumption during the period of an asset that is not used in production.

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Amount before accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

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Amount after accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business to produce goods and services and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

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Composition of Other Balance Sheet Items - Property and Equipment (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021	Dec. 31, 2021
Property and equipment
Property and equipment, gross	$ 28,810		$ 28,810		$ 33,409
Less accumulated depreciation and amortization	(12,938)		(12,938)		(16,454)
Property and equipment, net	15,872		15,872		16,955
Depreciation and amortization expense	800	$ 600	2,200	$ 1,900
Lab equipment and furniture
Property and equipment
Property and equipment, gross	12,207		12,207		12,287
Leasehold improvements
Property and equipment
Property and equipment, gross	14,023		14,023		14,369
Software
Property and equipment
Property and equipment, gross	1,007		1,007		4,776
Computer equipment
Property and equipment
Property and equipment, gross	1,282		1,282		1,944
Construction-in-progress
Property and equipment
Property and equipment, gross	$ 291		$ 291		$ 33