Share-Based Payments - Share-based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Share-based payments
Total	$ 4,985	$ 4,027	$ 13,307	$ 13,874
Research and development
Share-based payments
Total	825	615	2,284	1,909
Selling, general and administrative
Share-based payments
Total	$ 4,160	$ 3,412	$ 11,023	$ 11,965