Share-Based Payments - Share-based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Share-based payments
Total	$ 4,297	$ 5,476	$ 8,322	$ 9,847
Research and development
Share-based payments
Total	808	706	1,459	1,294
Selling, general and administrative
Share-based payments
Total	$ 3,489	$ 4,770	$ 6,863	$ 8,553