Composition of Balance Sheet Items - Accrued Payable and Accrued Liabilities (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Accounts payable	$ 12,323	$ 9,331
Accrued professional fees	16,209	26,728
Accrued compensation	14,555	28,068
Accrued product costs	12,727	18,460
Accrued royalties	11,044	13,821
Accrued clinical trial costs	7,784	9,125
Operating lease liabilities, current portion	6,141	6,477
Other accrued expenses	8,649	5,673
Total	$ 89,432	$ 117,683