Property and Equipment (Details) - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Property and equipment
Total property and equipment, gross	$ 33,409	$ 54,864
Finance lease assets	0	22,747
Less accumulated depreciation and amortization	(16,454)	(17,040)
Property and equipment, net	16,955	37,824
Depreciation and amortization expense	2,600	4,300	$ 1,500
Amortization on finance lease asset	0	1,873
Lab equipment and furniture
Property and equipment
Property and equipment, gross	12,287	12,526
Leasehold improvements
Property and equipment
Property and equipment, gross	14,369	15,183
Software
Property and equipment
Property and equipment, gross	4,776	2,295
Computer equipment
Property and equipment
Property and equipment, gross	1,944	2,113
Construction-in-progress
Property and equipment
Property and equipment, gross	$ 33	$ 0

The current period expense charged against earnings on long-lived, physical assets not used in production, and which are not intended for resale, to allocate or recognize the cost of such assets over their useful lives; or to record the reduction in book value of an intangible asset over the benefit period of such asset; or to reflect consumption during the period of an asset that is not used in production.

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