Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Cash flows from operating activities
Net earnings	$ 53,424	$ 126,950	$ 113,056
Adjustments to reconcile net earnings to net cash provided by operating activities:
Depreciation and amortization	32,595	18,141	6,659
Navitor investment R&D expense	15,000	0	0
Amortization of deferred financing costs and debt discount	17,501	16,581	15,708
Share-based compensation expense	17,910	16,561	14,846
Realized gains from sales of marketable securities	(347)	(4,352)	(301)
Amortization of premium/discount on marketable securities	418	(2,889)	(4,034)
Changes in fair value of contingent consideration	(6,530)	1,900	0
Other noncash adjustments, net	(1,420)	1,454	2,226
Deferred income tax (benefit) provision	(4,994)	568	(5,832)
Changes in operating assets and liabilities:
Accounts receivable	3,867	(34,607)	15,751
Inventories	(14,580)	(10,124)	(969)
Prepaid expenses and other assets	(8,398)	(10,442)	(2,864)
Accrued product returns and rebates	4,502	10,386	566
Accounts payable and other liabilities	18,179	8,272	(11,683)
Net cash provided by operating activities	127,127	138,399	143,129
Cash flows from investing activities
Sales and maturities of marketable securities	530,509	378,422	253,170
Purchases of marketable securities	(311,573)	(95,890)	(409,707)
Acquisition of USWM, net of cash acquired	(950)	(298,541)	0
Acquisition of Adamas, net of cash acquired	(310,742)	0	0
Distribution from (investment in) Navitor	12,888	(15,000)	0
Purchase of property and equipment and deferred legal fees paid	(2,045)	(3,690)	(1,387)
Net cash used in investing activities	(81,913)	(34,699)	(157,924)
Cash flows from financing activities
Proceeds from issuance of common stock	7,095	4,361	3,928
Proceeds from governmental loan and grant	800	0	0
Repayment of acquired Adamas loan	(138,315)	0	0
Payments on finance lease liability	0	(802)	0
Net cash (used in) provided by financing activities	(130,420)	3,559	3,928
Net change in cash and cash equivalents	(85,206)	107,259	(10,867)
Cash and cash equivalents at beginning of year	288,640	181,381	192,248
Cash and cash equivalents at end of year	203,434	288,640	181,381
Supplemental cash flow information:
Cash paid for interest on convertible notes	2,516	2,516	2,516
Cash paid for operating leases	11,908	6,949	5,337
Income taxes paid	25,190	45,428	51,540
Noncash investing and financing activity:
Contingent consideration liability related to acquisitions	10,307	76,700	0
Lease assets and tenant receivable obtained for new operating leases	10,868	2,478	35,594
Lease assets obtained for new finance lease	0	22,747	0
Property and equipment additions from utilization of tenant improvement allowance	$ 25	$ 0	$ 10,151