Consolidated Statements of Earnings - USD ($) $ in Thousands		12 Months Ended
		Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenue
Total revenues		$ 579,775	$ 520,397	$ 392,755
Costs and expenses
Costs of goods sold	[1]	75,061	52,459	16,660
Research and development		90,467	75,961	69,099
Selling, general and administrative		304,759	200,677	153,246
Amortization of intangible assets		29,989	15,702	5,179
Contingent consideration (gain) expense		(6,530)	1,900	0
Total costs and expenses		493,746	346,699	244,184
Operating earnings		86,029	173,698	148,571
Other (expense) income
Interest expense		(23,423)	(23,754)	(22,707)
Interest and other income, net		10,569	18,704	21,623
Total other expense		(12,854)	(5,050)	(1,084)
Earnings before income taxes		73,175	168,648	147,487
Income tax expense		19,751	41,698	34,431
Net earnings		$ 53,424	$ 126,950	$ 113,056
Earnings per share
Basic (in dollars per share)		$ 1.01	$ 2.41	$ 2.16
Diluted (in dollars per share)		$ 0.98	$ 2.36	$ 2.10
Weighted-average shares outstanding
Basic (in shares)		53,099,330	52,615,269	52,412,181
Diluted (in shares)		54,356,744	53,689,743	53,816,754
Net product sales
Revenue
Total revenues		$ 567,504	$ 509,350	$ 383,400
Royalty revenue
Revenue
Total revenues		$ 12,271	$ 11,047	$ 9,355

[1] Excludes amortization of acquired intangible assets.