Other (Expense) Income (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Other Income and Expenses [Abstract]
Interest expense	$ (19,696)	$ (19,435)	$ (18,207)
Interest expense on nonrecourse liability related to sale of future royalties	(3,727)	(4,319)	(4,500)
Total other expense	(23,423)	(23,754)	(22,707)
Amortization of deferred financing costs and debt discount	17,501	16,581	15,708
Interest earned from cash, cash equivalents, and marketable securities	$ 8,800	$ 16,000	$ 21,300