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Share-Based Payments (Tables)
 3 Months Ended
Mar. 31, 2020
Share-based Payment Arrangement [Abstract]  
Schedule of share-based compensation expense
Share-based compensation expense is as follows (dollars in thousands):
Three Months ended
March 31,
20202019
(unaudited)
Research and development$681  $574  
Selling, general and administrative3,307  2,713  
Total$3,988  $3,287  
Summary of stock options and SAR activities
The following table summarizes stock option and stock appreciation rights (SAR) activities:
Number of
Options		Weighted-
Average
Exercise Price
(per share)		Weighted-
Average
Remaining
Contractual
Term (in years)
Outstanding, December 31, 20194,606,559  $23.05  6.66
Granted 1,105,925  $23.99  
Exercised (3,811) $8.33  
Forfeited (25,275) $28.12  
Outstanding, March 31, 2020 (unaudited)5,683,398  $23.22  7.08
As of December 31, 2019:
Vested and expected to vest4,606,559  $23.05  6.66
Exercisable2,598,112  $15.68  5.48
As of March 31, 2020:
Vested and expected to vest5,683,398  $23.22  7.08
Exercisable 3,394,315  $18.71  5.75