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Property and Equipment (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2019
Sep. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Dec. 31, 2018
Property and equipment          
Property and equipment, gross $ 22,307   $ 22,307   $ 15,314
Less accumulated depreciation and amortization (12,330)   (12,330)   (11,219)
Property and equipment, net 9,977   9,977   4,095
Depreciation and amortization expense 400 $ 600 1,100 $ 1,500  
Lab equipment and furniture          
Property and equipment          
Property and equipment, gross 9,526   9,526   8,995
Leasehold improvements          
Property and equipment          
Property and equipment, gross 8,884   8,884   2,731
Software          
Property and equipment          
Property and equipment, gross 2,225   2,225   2,181
Computer equipment          
Property and equipment          
Property and equipment, gross 1,334   1,334   1,313
Construction-in-progress          
Property and equipment          
Property and equipment, gross $ 338   $ 338   $ 94