Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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The current period expense charged against earnings on long-lived, physical assets not used in production, and which are not intended for resale, to allocate or recognize the cost of such assets over their useful lives; or to record the reduction in book value of an intangible asset over the benefit period of such asset; or to reflect consumption during the period of an asset that is not used in production.

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Amount before accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

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Amount after accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business to produce goods and services and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

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Property and Equipment (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
Property and Equipment (Details) - USD ($) $ in Thousands	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018	Dec. 31, 2018
Property and equipment
Property and equipment, gross	$ 15,990		$ 15,990		$ 15,314
Less accumulated depreciation and amortization	(11,962)		(11,962)		(11,219)
Property and equipment, net	4,028		4,028		4,095
Depreciation and amortization expense	400	$ 500	700	$ 900
Lab equipment and furniture
Property and equipment
Property and equipment, gross	9,133		9,133		8,995
Leasehold improvements
Property and equipment
Property and equipment, gross	3,163		3,163		2,731
Software
Property and equipment
Property and equipment, gross	2,212		2,212		2,181
Computer equipment
Property and equipment
Property and equipment, gross	1,289		1,289		1,313
Construction-in-progress
Property and equipment
Property and equipment, gross	$ 193		$ 193		$ 94