Consolidated Statements of Cash Flows (USD $) In Thousands, unless otherwise specified	9 Months Ended
	Sep. 30, 2013	Sep. 30, 2012
Cash flows from operating activities
Net loss	$ (69,867)	$ (32,771)
Adjustments to reconcile loss to net cash used in operating activities:
Loss on extinguishment of debt	1,162
Change in fair value of derivative liabilities	12,692	766
Unrealized (loss) gain on marketable securities	(24)	(29)
Depreciation and amortization	526	650
Amortization of deferred financing costs and debt discount	2,070	248
Stock-based compensation expense	1,260	235
Changes in operating assets and liabilities :
Accounts receivable	(7,208)	(372)
Interest receivable	(319)	(341)
Inventory	(4,036)	(26)
Prepaid expenses and other assets	(822)	(597)
Accounts payable and accrued expenses	4,339	761
Deferred product revenue, net	10,365
Deferred licensing revenue	869	259
Other non-current liabilities	465	158
Net cash used in operating activities	(48,528)	(31,059)
Cash flows from investing activities
Purchases of marketable securities	(78,968)	(56,476)
Sales and maturities of marketable securities	47,666	17,416
Purchases of property and equipment, net	(1,414)	(553)
Payments to Acquire Intangible Assets	(306)
Net cash used in investing activities	(33,022)	(39,613)
Cash flows from financing activities
Proceeds from issuance of common stock	2,164	52,447
Proceeds from convertible debt issuances	90,000
Repayment of secured notes payable	(24,344)	(4,019)
Financing costs and underwriters discounts	(3,627)	(2,888)
Net cash used in financing activities	64,193	45,540
Net change in cash and cash equivalents	(17,357)	(25,132)
Cash and cash equivalents at beginning of period	40,302	48,544
Cash and cash equivalents at end of period	22,945	23,412
Supplemental cash flow information:
Cash paid for interest	975	2,257
Noncash financial activity:
Conversion of preferred stock		49
Initial value of interest make-whole derivatives
Issued in connection with the convertible debt	9,270
Debt Instrument, Convertible, Carrying Amount of Equity Component	$ 22,336