Consolidated Statements of Operations - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016
Revenue
Net product sales	$ 78,066	$ 55,618	$ 207,763	$ 148,978
Royalty revenue	2,010	1,140	4,338	3,464
Licensing revenue	322	52	1,702	187
Total revenue	80,398	56,810	213,803	152,629
Costs and expenses
Cost of product sales	4,251	3,428	11,060	8,214
Research and development	12,980	7,868	33,405	29,539
Selling, general and administrative	40,825	25,675	104,141	76,956
Total costs and expenses	58,056	36,971	148,606	114,709
Operating income	22,342	19,839	65,197	37,920
Other income (expense)
Interest income	814	378	2,002	1,071
Interest expense		(202)	(148)	(577)
Interest expense-nonrecourse liability related to sale of future royalties	(155)	(1,004)	(1,274)	(3,564)
Changes in fair value of derivative liabilities		125	76	349
Loss on extinguishment of debt	(91)		(295)	(382)
Total other income (expense)	568	(703)	361	(3,103)
Earnings before income taxes	22,910	19,136	65,558	34,817
Income tax expense (benefit)	6,949	(42,690)	21,932	(42,085)
Net income	$ 15,961	$ 61,826	$ 43,626	$ 76,902
Earnings per share:
Basic (in dollars per share)	$ 0.31	$ 1.25	$ 0.86	$ 1.56
Diluted (in dollars per share)	$ 0.29	$ 1.18	$ 0.82	$ 1.48
Weighted-average number of common shares outstanding:
Basic (in shares)	51,046,375	49,516,595	50,583,726	49,395,284
Diluted (in shares)	53,628,389	51,974,435	53,227,433	51,615,334