Share-Based Payments (Tables)

3 Months Ended

Mar. 31, 2017

Share-Based Payments

Schedule of share-based compensation recognized related to the grant of employee and non-employee stock options, SAR, Employee Stock Purchase Plan (ESPP) awards and non-vested stock

Share-based compensation recognized related to the grant of employee and non-employee stock options, SAR, Employee Stock Purchase Plan (ESPP) awards and non-vested stock was as follows, in thousands:

	March 31,
	2017		2016
	(unaudited)
Research and development	$	317	$	288
Selling, general and administrative	1,510		1,071
Total	$	1,827	$	1,359

Summary of stock option and SAR activity

	Number of Options		Weighted- Average Exercise Price		Weighted- Average Remaining Contractual Term (in years)
Outstanding, December 31, 2016	3,644,088		$	10.25	7.59
Granted (unaudited)	1,028,525		$	25.30
Exercised (unaudited)	(64,901	)	$	9.31
Forfeited or expired (unaudited)	(4,575	)	$	17.38
Outstanding, March 31, 2017	4,603,137		$	13.62	7.92
As of December 31, 2016:
Vested and expected to vest	3,591,528		$	10.22	7.57
Exercisable	1,503,004		$	8.62	6.49
As of March 31, 2017:
Vested and expected to vest (unaudited)	4,603,137		$	13.62	7.92
Exercisable (unaudited)	2,238,770		$	9.23	6.73